Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Julien Bensalem is a post-doctoral researcher in the Lysosomal Health in Ageing group, Hopwood Centre for Neurobiology, Lifelong Health Theme, at SAHMRI and an affiliate senior lecturer with the Adelaide Medical School at the University of Adelaide.
Dr Julien Bensalem completed his PhD specialised in Nutrition in 2014 at the University of Bordeaux, France, studying the effect of polyphenols on the age-related cognitive decline.
Following his PhD, he worked as research project manager in a French company developing new nutritional plant extracts for different health applications, while pursuing his research on nutrition and cognition as a postdoc in the Laboratory of Nutrition and Integrative Neuroscience in Bordeaux, France.
Dr Bensalem joined the Lysosomal Health in Ageing, Hopwood Centre for Neurobiology at SAHMRI, Australia, in 2018 as a post-doctoral researcher under Dr Tim Sargeant supervision. In his current role he investigates how nutrition can be used to tackle dementia by improving autophagy, and how autophagy is involved in other age-related diseases such as diabetes and cardiovascular disease.
Alzheimer’s disease is responsible for 60-70% of the 50 million cases of dementia around the world. Although billions of dollars have been spent on developing therapies, there is still no treatment available.
Alzheimer’s disease leads to the progressive formation and spread of abnormal and toxic material in the brain, which impairs its function and causes dementia. Our group has found that autophagy, our cell's "self-cleaning" system, can destroy this toxic material and that we can up-regulate autophagy in preclinical models using drugs or restricting certain nutrients in the diet.
As part of my research, I have developed the first blood test to measure autophagic activity in humans. This is an important step forward to translate our preclinical knowledge about autophagy to the clinic. I am currently studying how autophagy responds to nutritional interventions in humans and how autophagy behaves in relation to age-related diseases, including cardiovascular disease and Alzheimer's disease. I also use laboratory models to determine how autophagy changes in the brain in response to nutrition and age- and obesity-related damage.
My overarching research aim is to develop new treatment strategies that protect autophagy cleaning ability in the brain of people at risk of developing Alzheimer’s disease.
Date Position Institution name 2022 - ongoing Affiliate Senior Lecturer University of Adelaide 2018 - ongoing Postdoctoral Researcher South Australian Health and Medical Research Institute 2015 - 2017 Affiliate postdoctoral researcher Nutrition and Integrative Neurobiology (NutriNeurO) 2015 - 2017 Research project Manager Activ'Inside 2011 - 2014 PhD candidate University of Bordeaux
Language Competency English Can read, write, speak, understand spoken and peer review French Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2011 - 2014 University of Bordeaux France PhD 2009 - 2010 Paul Sabatier University France Masters 2008 - 2009 University of Bordeaux France Bachelors (Honours) 2005 - 2008 University of Bordeaux France Bachelors of Science
Year Citation 2023 Bensalem, J., Hein, L. K., Hassiotis, S., Trim, P. J., Proud, C. G., Heilbronn, L. K., & Sargeant, T. J. (2023). Modifying Dietary Protein Impacts mTOR Signaling and Brain Deposition of Amyloid β in a Knock-In Mouse Model of Alzheimer Disease. Journal of Nutrition, 153(5), 1407-1419.
2023 Teong, X. T., Liu, K., Vincent, A. D., Bensalem, J., Liu, B., Hattersley, K. J., . . . Heilbronn, L. K. (2023). Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial. Nature Medicine, 29(4), 963-972.
DOI Scopus1 WoS1
2022 Vidanapathirana, A. K., Goyne, J. M., Williamson, A. E., Pullen, B. J., Chhay, P., Sandeman, L., . . . Bursill, C. A. (2022). Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor. Biomedicines, 10(8), 1807.
DOI Scopus2 WoS2 Europe PMC1
2022 Bensalem, J., Heilbronn, L. K., Gore, J. R., Hutchison, A. T., Sargeant, T. J., & Fourrier, C. (2022). The Break-Fast study protocol: a single arm pre-post study to measure the effect of a protein-rich breakfast on autophagic flux in fasting healthy individuals. BMC Nutrition, 8(1), 120-1-120-7.
2022 Carosi, J. M., Fourrier, C., Bensalem, J., & Sargeant, T. J. (2022). The mTOR–lysosome axis at the centre of ageing. FEBS Open Bio, 12(4), 739-757.
DOI Scopus14 WoS13 Europe PMC2
2022 Whyte, L. S., Fourrier, C., Hassiotis, S., Lau, A. A., Trim, P. J., Hein, L. K., . . . Sargeant, T. J. (2022). Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease. IBRO Neuroscience Reports, 12, 131-141.
DOI Scopus4 Europe PMC3
2022 Chaudhary, R., Liu, B., Bensalem, J., Sargeant, T. J., Page, A. J., Wittert, G. A., . . . Heilbronn, L. K. (2022). Intermittent fasting activates markers of autophagy in mouse liver, but not muscle from mouse or humans. Nutrition, 101, 111662.
DOI Scopus1 WoS1
2021 Fourrier, C., Bryksin, V., Hattersley, K., Hein, L. K., Bensalem, J., & Sargeant, T. J. (2021). Comparison of chloroquine-like molecules for lysosomal inhibition and measurement of autophagic flux in the brain. Biochemical and Biophysical Research Communications, 534, 107-113.
DOI Scopus3 WoS3 Europe PMC2
2021 Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . Aurelian, L. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>. Autophagy, 17(1), 1-382.
DOI Scopus899 WoS658 Europe PMC676
2021 Bensalem, J., Fourrier, C., Hein, L. K., Hassiotis, S., Proud, C. G., & Sargeant, T. J. (2021). Inhibiting mTOR activity using AZD2014 increases autophagy in the mouse cerebral cortex. Neuropharmacology, 190, 15 pages.
DOI Scopus6 WoS5 Europe PMC2
2021 Hattersley, K. J., Carosi, J. M., Hein, L. K., Bensalem, J., & Sargeant, T. J. (2021). PICALM regulates cathepsin D processing and lysosomal function. Biochemical and Biophysical Research Communications, 570, 103-109.
DOI Scopus2 WoS2 Europe PMC1
2021 Lynn, M. A., Eden, G., Ryan, F. J., Bensalem, J., Wang, X., Blake, S. J., . . . Lynn, D. J. (2021). The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life. Cell Reports, 36(8), 20 pages.
DOI Scopus17 WoS10 Europe PMC10
2021 Sargeant, T. J., & Bensalem, J. (2021). Human autophagy measurement: an underappreciated barrier to translation. Trends in Molecular Medicine, 27(12), 1091-1094.
DOI Scopus3 WoS3 Europe PMC2
2020 Bensalem, J., Hattersley, K. J., Hein, L. K., Tong Teong, X., Carosi, J. M., Hassiotis, S., . . . Sargeant, T. J. (2020). Measurement of autophagic flux in humans: an optimized method for blood samples.. Autophagy, 17(10), 3238-3255.
DOI Scopus13 WoS13 Europe PMC9
2019 Bensalem, J., Dudonné, S., Etchamendy, N., Pellay, H., Amadieu, C., Gaudout, D., . . . Pallet, V. (2019). Polyphenols from Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74(7), 996-1007.
DOI Scopus52 WoS44 Europe PMC27
2018 Lefèvre-Arbogast, S., Gaudout, D., Bensalem, J., Letenneur, L., Dartigues, J. F., Hejblum, B. P., . . . Samieri, C. (2018). Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology, 90(22), e1979-e1988.
DOI Scopus39 WoS36 Europe PMC19
2018 Bensalem, J., Dudonné, S., Gaudout, D., Servant, L., Calon, F., Desjardins, Y., . . . Pallet, V. (2018). Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice. Journal of Nutritional Science, 7, e19.
DOI Scopus45 Europe PMC30
2016 Martineau, A. S., Leray, V., Lepoudere, A., Blanchard, G., Bensalem, J., Gaudout, D., . . . Nguyen, P. (2016). A mixed grape and blueberry extract is safe for dogs to consume. BMC Veterinary Research, 12(1), 10 pages.
DOI Scopus9 WoS9 Europe PMC8
2016 Bensalem, J., Servant, L., Alfos, S., Gaudout, D., Layé, S., Pallet, V., & Lafenetre, P. (2016). Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice. Frontiers in Behavioral Neuroscience, 10(FEB), 16 pages.
DOI Scopus24 WoS21 Europe PMC15
2016 Bensalem, J., Dal-Pan, A., Gillard, E., Calon, F., & Pallet, V. (2016). Protective effects of berry polyphenols against age-related cognitive impairment. Nutrition and Aging, 3(2-4), 89-106.
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