Associate Professor Jonathan George

• Appointments

  Date	Position	Institution name
  2018 - ongoing	Associate Professor	University of Adelaide
  2014 - 2017	Senior Lecturer	University of Adelaide
  2010 - 2013	Lecturer	University of Adelaide

• Awards and Achievements

  Date	Type	Title	Institution Name	Country	Amount
  2017	Fellowship	ARC Future Fellowship	Australian Research Council	Australia	-
  2015	Award	Athel Beckwith Lectureship	RACI	Australia	-
  2014	Award	Thieme Chemistry Journal Award	Thieme	Germany	-
  2013	Fellowship	ARC DECRA Fellowship	Australian Research Council	Australia	-

• Education

  Date	Institution name	Country	Title
  2003 - 2007	University College London, London	United Kingdom	PhD
  1997 - 2001	University of Oxford, Oxford	United Kingdom	MChem

• Journals

  Year	Citation
  2023	zur Bonsen, A. B., Sumby, C. J., & George, J. H. (2023). Bioinspired Total Synthesis of Hyperireflexolides A and B. Organic Letters, 25(34), A-E. DOI
  2022	Yahiaoui, O., Murray, L. A. M., Zhao, F., Moore, B. S., Houk, K. N., Liu, F., & George, J. H. (2022). A Diazo-Hooker Reaction, Inspired by the Biosynthesis of Azamerone. Organic Letters, 24(2), 490-495. DOI Scopus3 WoS3
  2022	Sassnink, S. A., Phan, Q. D., Lam, H. C., Day, A. J., Murray, L. A. M., & George, J. H. (2022). Biomimetic synthesis of the non-canonical PPAP natural products yezo'otogirin C and hypermogin D, and studies towards the synthesis of norascyronone A. Organic and Biomolecular Chemistry, 20(8), 1759-1768. DOI Scopus2 WoS1 Europe PMC1
  2022	Franov, L. J., Hart, J. D., Pullella, G. A., Sumby, C. J., & George, J. H. (2022). Bioinspired total synthesis of erectones A and B, and the revised structure of hyperelodione D. Angewandte Chemie International Edition, 61(19), e202200420-1-e202200420-5. DOI Scopus5 WoS5 Europe PMC2
  2022	Zur Bonsen, A. B., Peralta, R. A., Fallon, T., Huang, D. M., & George, J. H. (2022). Intramolecular Tricarbonyl-Ene Reactions and α-Hydroxy-β-Diketone Rearrangements Inspired by the Biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols. Angewandte Chemie International Edition, 61(34), 1-10. DOI Scopus1 WoS1 Europe PMC1
  2022	Chen, P. Y. -T., Adak, S., Chekan, J. R., Liscombe, D. K., Miyanaga, A., Bernhardt, P., . . . Moore, B. S. (2022). Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis.. Biochemistry, 61(17), 1844-1852. DOI Scopus4 WoS4 Europe PMC3
  2022	French, S. A., Sumby, C. J., Huang, D. M., & George, J. H. (2022). Total Synthesis of Atrachinenins A and B. Journal of the American Chemical Society, 144(50), 22844-22849. DOI
  2022	Vieira de Castro, T., Huang, D. M., Sumby, C. J., Lawrence, A. L., & George, J. H. (2022). A bioinspired, one-step total synthesis of peshawaraquinone. Chemical Science, 14(4), 950-954. DOI
  2021	Burchill, L., Day, A. J., Yahiaoui, O., & George, J. H. (2021). Biomimetic total synthesis of the rubiginosin meroterpenoids. Organic Letters, 23(2), 578-582. DOI Scopus9 WoS8 Europe PMC1
  2021	George, J. H. (2021). Biomimetic dearomatization strategies in the total synthesis of meroterpenoid natural products. Accounts of Chemical Research, 54(8), 1843-1855. DOI Scopus19 WoS18 Europe PMC4
  2020	Day, A. J., Sumby, C. J., & George, J. H. (2020). Biomimetic synthetic studies on the bruceol family of meroterpenoid natural products. Journal of Organic Chemistry, 85(4), 2103-2117. DOI Scopus13 WoS13 Europe PMC3
  2020	Burchill, L., & George, J. H. (2020). Total synthesis of rhodonoids A B, E, and F, enabled by singlet oxygen ene reactions. Journal of Organic Chemistry, 85(4), 2260-2265. DOI Scopus10 WoS11 Europe PMC1
  2020	Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products from streptomyces bacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports: a journal of current development in bioorganic chemistry, 37(1), 1-33. DOI Scopus37 WoS37 Europe PMC10
  2020	Day, A. J., & George, J. H. (2020). Isolation and biomimetic oxidation of prenylbruceol A, an anticipated meroterpenoid natural product from philotheca myoporoides. Journal of Natural Products, 83(7), 2305-2309. DOI Scopus3 WoS3 Europe PMC1
  2020	Vieira de Castro, T., Yahiaoui, O., Peralta, R. A., Fallon, T., Lee, V., & George, J. H. (2020). Biomimetic synthesis enables the structure revision of littordials E and F and drychampone B. Organic Letters, 22(20), 8161-8166. DOI Scopus13 WoS13 Europe PMC2
  2019	Hart, J. D., Burchill, L., Day, A. J., Newton, C. G., Sumby, C. J., Huang, D. M., & George, J. H. (2019). Visible-light photoredox catalysis enables the biomimetic synthesis of nyingchinoids A, B, and D, and rasumatranin D. Angewandte Chemie, 131(9), 2817-2820. DOI
  2019	Day, A. J., Lee, J. H. Z., Phan, Q. D., Lam, H. C., Ametovski, A., Sumby, C. J., . . . George, J. H. (2019). Biomimetic and biocatalytic synthesis of bruceol. Angewandte Chemie - International Edition, 58(5), 1427-1431. DOI Scopus11 WoS9 Europe PMC1
  2019	Hart, J. D., Burchill, L., Day, A. J., Newton, C. G., Sumby, C. J., Huang, D. M., & George, J. H. (2019). Visible-light photoredox catalysis enables the biomimetic synthesis of nyingchinoids A, B, and D, and rasumatranin D. Angewandte Chemie International Edition, 58(9), 2791-2794. DOI Scopus22 WoS19 Europe PMC1
  2019	Kuan, K. K., Markwell-Heys, A., Cruickshank, M. C., Tran, D. P., Adlington, R., Baldwin, J., & George, J. (2019). Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D. Bioorganic and Medicinal Chemistry, 27(12), 2449-2465. DOI Scopus8 WoS8 Europe PMC2
  2019	Murray, L. A. M., Fallon, T., Sumby, C. J., & George, J. H. (2019). Total synthesis of naphterpin and marinone natural products. Organic Letters, 21(20), 8312-8315. DOI Scopus20 WoS16 Europe PMC4
  2019	Coleman, M. A., Burchill, L., Sumby, C. J., & George, J. H. (2019). Biomimetic synthesis enables the structure revision of furoerioaustralasine. Organic Letters, 21(21), 8776-8778. DOI Scopus14 WoS14 Europe PMC1
  2019	Burchill, L., Pepper, H. P., Sumby, C. J., & George, J. H. (2019). ortho-Quinone methide cyclizations inspired by the busseihydroquinone family of natural products. Organic Letters, 21(20), 8304-8307. DOI Scopus7 WoS6
  2018	Murray, L., Mckinnie, S., Pepper, H., Erni, R., Miles, Z., Cruickshank, M., . . . George, J. (2018). Total synthesis establishes the biosynthetic pathway to the naphterpin and marinone natural products. Angewandte Chemie - International Edition, 57(34), 11009-11014. DOI Scopus35 WoS35 Europe PMC12
  2018	Lam, H., Phan, Q., Sumby, C., & George, J. (2018). Biomimetic synthesis of hyperjapones F-I. Australian Journal of Chemistry, 71(9), 649-654. DOI Scopus6 WoS4
  2018	McKinnie, S., Miles, Z., Jordan, P., Awakawa, T., Pepper, H., Murray, L., . . . Moore, B. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840-17845. DOI Scopus35 WoS35 Europe PMC19
  2017	Lam, H., Pepper, H., Sumby, C., & George, J. (2017). Biomimetic total synthesis of (±)-verrubenzospirolactone. Angewandte Chemie - International Edition, 56(29), 8532-8535. DOI Scopus26 WoS27 Europe PMC5
  2017	Day, A., Lamr, H., Sumby, C., & George, J. (2017). Biomimetic total synthesis of rhodonoids C and D, and murrayakonine D. Organic Letters, 19(10), 2463-2465. DOI Scopus16 WoS16 Europe PMC2
  2017	Pepper, H., Lam, H., & George, J. (2017). Biosynthetically-inspired oxidations of capillobenzopyranol. Organic and Biomolecular Chemistry, 15(22), 4811-4815. DOI Scopus6 WoS6 Europe PMC1
  2017	Miles, Z., Diethelm, S., Pepper, H., Huang, D., George, J., & Moore, B. (2017). A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis. Nature Chemistry, 9(12), 1235-1242. DOI Scopus55 WoS50 Europe PMC19
  2017	López-Pérez, B., Pepper, H., Ma, R., Fawcett, B., Pehere, A., Wei, Q., . . . George, J. (2017). Biosynthetically guided structure-activity relationship studies of Merochlorin A, an antibiotic marine natural product. ChemMedChem, 12(23), 1969-1976. DOI Scopus16 WoS15 Europe PMC6
  2016	Markwell-Heys, A., & George, J. (2016). Some chemical speculation on the biosynthesis of corallidictyals A-D. Organic and Biomolecular Chemistry, 14(24), 5546-5549. DOI Scopus23 WoS21 Europe PMC8
  2016	Zhang, X., Bruning, J., George, J., & Abell, A. (2016). A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Organic and Biomolecular Chemistry, 14(29), 6970-6978. DOI Scopus10 WoS10
  2016	Lam, H., Spence, J., & George, J. (2016). Biomimetic total synthesis of hyperjapones A–E and hyperjaponols A and C. Angewandte Chemie - International Edition, 55(35), 10368-10371. DOI Scopus51 WoS47 Europe PMC13
  2016	Kuan, K., Hirschvogel, A., & George, J. (2016). A biomimetic synthetic approach to the frondosins. Australian Journal of Chemistry, 69(12), 1420-1423. DOI Scopus3 WoS3
  2015	Markwell-Heys, A., Kuan, K., & George, J. (2015). Total synthesis and structure revision of (-)-siphonodictyal B and its biomimetic conversion into (+)-liphagal. Organic Letters, 17(17), 4228-4231. DOI Scopus37 WoS36 Europe PMC8
  2015	Bruce, M., Burgun, A., George, J., Nicholson, B., Parker, C., Skelton, B., . . . Zaitseva, N. (2015). Some reactions of azides with diynyl-bis(phosphine)ruthenium-cyclopentadienyl complexes. Journal of Organometallic Chemistry, 797, 185-193. DOI Scopus1 WoS1
  2015	Pepper, H., & George, J. (2015). The biosynthesis and biomimetic synthesis of merochlorins A and B. Synlett, 26(18), 2485-2490. DOI Scopus6 WoS6
  2015	Spence, J., & George, J. (2015). Total synthesis of peniphenones A-D via biomimetic reactions of a common o-Quinone methide intermediate. Organic Letters, 17(24), 5970-5973. DOI Scopus32 WoS32 Europe PMC8
  2014	Pepper, H., Tulip, S., Nakano, Y., & George, J. (2014). Biomimetic total synthesis of (±)-doitunggarcinone A and (+)-garcibracteatone. Journal of Organic Chemistry, 79(6), 2564-2573. DOI Scopus46 WoS48 Europe PMC9
  2014	Bell, S., Spence, J., Liu, S., George, J., & Wong, L. (2014). Selective aliphatic carbon-hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes. Organic and Biomolecular Chemistry, 12(15), 2479-2488. DOI Scopus11 WoS11 Europe PMC6
  2014	Lam, H., Kuan, K., & George, J. (2014). Biomimetic total synthesis of (±)-yezo'otogirin A. Organic and Biomolecular Chemistry, 12(16), 2519-2522. DOI Scopus14 WoS14 Europe PMC2
  2013	Pepper, H., & George, J. (2013). Biomimetic total synthesis of (±)-merochlorin A. Angewandte Chemie-International Edition, 52(46), 12170-12173. DOI Scopus30 WoS26 Europe PMC11
  2013	Spence, J., & George, J. (2013). Biomimetic total synthesis of ent-penilactone A and penilactone B. Organic Letters, 15(15), 3891-3893. DOI Scopus48 WoS44 Europe PMC16
  2012	Kuan, K., Pepper, H., Bloch, W., & George, J. (2012). Total synthesis of (+)-aureol. Organic Letters, 14(18), 4710-4713. DOI Scopus33 WoS33 Europe PMC15
  2012	Pepper, H., Lam, H., Bloch, W., & George, J. (2012). Biomimetic total synthesis of (±)-garcibracteatone. Organic Letters, 14(19), 5162-5164. DOI Scopus55 WoS53 Europe PMC7
  2012	Pepper, H., Kuan, K., & George, J. (2012). Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins. Organic Letters, 14(6), 1524-1527. DOI Scopus27 WoS26 Europe PMC3
  2011	Spence, J., & George, J. (2011). Structural reassignment of Cytosporolides A - C via biomimetic synthetic studies and reinterpretation of NMR data. Organic Letters, 13(19), 5318-5321. DOI Scopus52 WoS53 Europe PMC14
  2010	Hale, K., Manaviazar, S., & George, J. (2010). Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription. Chemical Communications, 46(23), 4021-4042. DOI Scopus26 WoS26 Europe PMC7
  2010	George, J., Baldwin, J., & Adlington, R. (2010). Enantiospecific, biosynthetically inspired formal total synthesis of (+)-Liphagal. Organic Letters, 12(10), 2394-2397. DOI Scopus85 WoS86 Europe PMC21
  2010	George, J., McArdle, M., Baldwin, J., & Adlington, R. (2010). Biomimetic rearrangements of simplified labdane diterpenoids. Tetrahedron, 66(33), 6321-6330. DOI Scopus32 WoS32
  2010	George, J., Hesse, M., Baldwin, J., & Adlington, R. (2010). Biomimetic synthesis of polycyclic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum. Organic Letters, 12(15), 3532-3535. DOI Scopus74 WoS72 Europe PMC26
  2009	Hale, K., Manaviazar, S., Lazarides, L., George, J., Walters, M., Cai, J., . . . El-Tanani, M. (2009). Synthesis of A83586C analogs with potent anticancer and beta-catenin/TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb. Organic Letters, 11(3), 737-740. DOI Scopus11 WoS11 Europe PMC5
  2009	Hale, K., Manaviazar, S., George, J., Walters, M., & Dalby, S. (2009). Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin. Organic Letters, 11(3), 733-736. DOI Scopus36 WoS33 Europe PMC11
  2008	George, J. H., & Adlington, R. M. (2008). A synthetic approach to the communesins. Synlett, 2008(14), 2093-2096. DOI Scopus36 WoS35
  2008	Assem, E., Peh, K., Wan, B., Manaviazar, S., Walters, M., George, J., & Hale, K. (2008). Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflammation Research, 57(Supplement 1), 21-22. DOI
  2005	Dimopoulos, P., George, J., Tocher, D., Manaviazar, S., & Hale, K. (2005). Mechanistic studies on the O-directed free radical hydrostannation of disubstituted acetylenes with Ph3SnH and Et3B and on the iodination of allylically oxygenated alpha-triphenylstannylalkenes. Organic Letters, 7(24), 5377-5380. DOI Scopus36 WoS36 Europe PMC11
  2005	Dimopoulos, P., Athlan, A., Manaviazar, S., George, J., Walters, M., Lazarides, L., . . . Hale, K. (2005). O-directed free-radical hydrostannations of propargyl ethers, acetals, and alcohols with Ph3SnH and Et3B. Organic Letters, 7(24), 5369-5372. DOI Scopus37 WoS36 Europe PMC8

Teaching

• Stereochemistry (2nd year)
• Organic reaction mechanisms (3rd year)
• Stereoselective synthesis (3rd year)

• Current Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2023	Co-Supervisor	Developing new methods for drug release targeting cell surface receptor density.	Doctor of Philosophy	Doctorate	Full Time	Ms Maya Liza Doyle
  2021	Principal Supervisor	Biomimetic Synthesis of Natural Products	Doctor of Philosophy	Doctorate	Full Time	Mr Matthew Alexander Coleman
  2021	Principal Supervisor	Biomimetic Total Synthesis of Natural Products	Doctor of Philosophy	Doctorate	Full Time	Miss Emma Caitlin Becroft
  2020	Principal Supervisor	Biomimetic Synthesis of Natural Products	Doctor of Philosophy	Doctorate	Full Time	Mr Andreas Benedikt Zur Bonsen
  2018	Principal Supervisor	Design, synthesis and applications of fluctional molecules	Doctor of Philosophy	Doctorate	Full Time	Mr Harshal Deepak Patel

• Past Higher Degree by Research Supervision (University of Adelaide)

  Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
  2022 - 2022	Principal Supervisor	Biomimetic Synthesis Enables the Structural Revision of Natural Products	Master of Philosophy	Master	Full Time	Mr Tomas Mendes Gouveia Vieira deCastro
  2019 - 2023	Principal Supervisor	A Diels-Alder Strategy for the Total Synthesis of para-Quinone Natural Products	Doctor of Philosophy	Doctorate	Full Time	Mr Jacob David Hart
  2019 - 2023	Principal Supervisor	Biomimetic Total Synthesis of Meroterpenoid Natural Products	Doctor of Philosophy	Doctorate	Full Time	Miss Sarah Alexandra French
  2017 - 2021	Principal Supervisor	Synthetic, Biomimetic and Chemoenzymatic Studies of Meroterpenoid Natural Products	Doctor of Philosophy	Doctorate	Full Time	Miss Lauren Ashleigh Marie Murray
  2017 - 2021	Principal Supervisor	Progress towards the Biomimetic Total Synthesis of Meroterpenoid Natural Products	Doctor of Philosophy	Doctorate	Full Time	Ms Stefania Sassnink
  2017 - 2021	Principal Supervisor	The Synthesis of Chromane Meroterpenoids via Biomimetic Cascade Reactions	Doctor of Philosophy	Doctorate	Full Time	Mr Aaron John Day
  2017 - 2021	Principal Supervisor	The Total Synthesis of Natural Products via Cascade Reactions	Doctor of Philosophy	Doctorate	Full Time	Miss Laura Jane Burchill
  2016 - 2018	Co-Supervisor	Inhibition of Serine and Cysteine Proteases by Peptidomimetic Inhibitors	Master of Philosophy	Master	Full Time	Mr Nicholas Charles Schumann
  2015 - 2019	Co-Supervisor	Development of New Antibiotics Based on Biotin Biology	Doctor of Philosophy	Doctorate	Full Time	Mr Kwang Jun Lee
  2014 - 2019	Co-Supervisor	Investigations into the Divergent, Biogenically Inspired Synthesis of Structurally Related Natural Products	Doctor of Philosophy	Doctorate	Full Time	Adrian Webster Markwell-Heys
  2014 - 2017	Principal Supervisor	Biomimetic Total Synthesis of Natural Products	Doctor of Philosophy	Doctorate	Full Time	Mr Hiu Chun Lam
  2014 - 2018	Co-Supervisor	Sensing in Biological Systems	Doctor of Philosophy	Doctorate	Full Time	Dr Georgina Maree Sylvia
  2012 - 2016	Co-Supervisor	Biomimetic Synthesis of Natural Products via Reactions of Ortho-Quinone Methides	Doctor of Philosophy	Doctorate	Full Time	Justin Thomas James Spence
  2012 - 2016	Co-Supervisor	Biomimetic Synthesis of Meroterpenoid Natural Products Using Dearomatization Strategies	Doctor of Philosophy	Doctorate	Full Time	Henry Patrick Pepper
  2011 - 2018	Co-Supervisor	A Study on Side Chain Linked Peptides, Toward the Development of Talin Inhibitors using B3 Integrin Peptide Analogues	Doctor of Philosophy	Doctorate	Part Time	Miss Kelly Lee Keeling
  2011 - 2016	Co-Supervisor	Biomimetic Synthesis of Marine Sponge Derived Natural Products	Doctor of Philosophy	Doctorate	Full Time	Mr Kevin Kuan
  2011 - 2015	Co-Supervisor	PEPTIDOMIMETIC PROTEASE INHIBITORS: ACTIVITY AND MECHANISM OF INHIBITION	Doctor of Philosophy	Doctorate	Part Time	Dr Xiao Zhou Zhang

• Position: Associate Prof/Reader
• Phone: 83135494
• Email: jonathan.george@adelaide.edu.au
• Fax: 83134380
• Campus: North Terrace
• Building: Badger, floor 1
• Org Unit: Chemistry