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Associate Professor Jonathan George

Associate Professor Jonathan George
Senior Lecturer
School of Physical Sciences
Faculty of Sciences

I studied chemistry at the University of Oxford, followed by a PhD in organic chemistry with Prof. Karl Hale at University College London. I then returned to Oxford to work as a post-doc with Prof. Sir Jack Baldwin and Dr. Rob Adlington. Since 2010 I have been a Lecturer (and now Senior Lecturer) in the Department of Chemistry at the University of Adelaide.

Connect With Me

Associate Professor Jonathan George

I studied chemistry at the University of Oxford, followed by a PhD in organic chemistry with Prof. Karl Hale at University College London. I then returned to Oxford to work as a post-doc with Prof. Sir Jack Baldwin and Dr. Rob Adlington. Since 2010 I have been a Lecturer (and now Senior Lecturer) in the Department of Chemistry at the University of Adelaide.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Research Interests

Please see the George group website for more information on our research.

 

Education

Date Institution name Country Title
University College London, London United Kingdom Ph D
University of Oxford, Oxford United Kingdom Master of Chemistry

Journals

Year Citation
2018 Murray, L., Mckinnie, S., Pepper, H., Erni, R., Miles, Z., Cruickshank, M., . . . George, J. (2018). Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angewandte Chemie - International Edition, 57(34), 11009-11014.
DOI
2017 Lam, H., Pepper, H., Sumby, C., & George, J. (2017). Biomimetic total synthesis of (±)-verrubenzospirolactone. Angewandte Chemie - International Edition, 56(29), 8532-8535.
DOI Scopus3 WoS2 Europe PMC1
2017 Pepper, H., Lam, H., & George, J. (2017). Biosynthetically-inspired oxidations of capillobenzopyranol. Organic and Biomolecular Chemistry, 15(22), 4811-4815.
DOI Scopus2 WoS2
2016 Markwell-Heys, A., & George, J. (2016). Some chemical speculation on the biosynthesis of corallidictyals A-D. Organic and Biomolecular Chemistry, 14(24), 5546-5549.
DOI Scopus8 WoS6 Europe PMC5
2016 Zhang, X., Bruning, J., George, J., & Abell, A. (2016). A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Organic and Biomolecular Chemistry, 14(29), 6970-6978.
DOI Scopus4 WoS4
2016 Lam, H., Spence, J., & George, J. (2016). Biomimetic total synthesis of hyperjapones A–E and hyperjaponols A and C. Angewandte Chemie - International Edition, 55(35), 10368-10371.
DOI Scopus18 WoS18 Europe PMC7
2016 Kuan, K., Hirschvogel, A., & George, J. (2016). A biomimetic synthetic approach to the frondosins. Australian Journal of Chemistry, 69(12), 1420-1423.
DOI Scopus2 WoS2
2015 Markwell-Heys, A., Kuan, K., & George, J. (2015). Total synthesis and structure revision of (-)-siphonodictyal B and its biomimetic conversion into (+)-liphagal. Organic Letters, 17(17), 4228-4231.
DOI Scopus20 WoS19 Europe PMC5
2015 Pepper, H., & George, J. (2015). The biosynthesis and biomimetic synthesis of merochlorins A and B. Synlett, 26(18), 2485-2490.
DOI Scopus4 WoS4
2015 Spence, J., & George, J. (2015). Total synthesis of peniphenones A-D via biomimetic reactions of a common o-Quinone methide intermediate. Organic Letters, 17(24), 5970-5973.
DOI Scopus10 WoS10 Europe PMC4
2014 Pepper, H., Tulip, S., Nakano, Y., & George, J. (2014). Biomimetic total synthesis of (±)-doitunggarcinone A and (+)-garcibracteatone. Journal of Organic Chemistry, 79(6), 2564-2573.
DOI Scopus12 WoS13 Europe PMC3
2014 Bell, S., Spence, J., Liu, S., George, J., & Wong, L. (2014). Selective aliphatic carbon-hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes. Organic and Biomolecular Chemistry, 12(15), 2479-2488.
DOI Scopus5 WoS5 Europe PMC3
2014 Lam, H., Kuan, K., & George, J. (2014). Biomimetic total synthesis of (±)-yezo'otogirin A. Organic and Biomolecular Chemistry, 12(16), 2519-2522.
DOI Scopus4 WoS4
2013 Pepper, H., & George, J. (2013). Biomimetic total synthesis of (±)-merochlorin A. Angewandte Chemie-International Edition, 52(46), 12170-12173.
DOI Scopus17 WoS15 Europe PMC6
2013 Spence, J., & George, J. (2013). Biomimetic total synthesis of ent-penilactone A and penilactone B. Organic Letters, 15(15), 3891-3893.
DOI Scopus25 WoS27 Europe PMC8
2012 Kuan, K., Pepper, H., Bloch, W., & George, J. (2012). Total synthesis of (+)-aureol. Organic Letters, 14(18), 4710-4713.
DOI Scopus22 WoS22 Europe PMC9
2012 Pepper, H., Lam, H., Bloch, W., & George, J. (2012). Biomimetic total synthesis of (±)-garcibracteatone. Organic Letters, 14(19), 5162-5164.
DOI Scopus31 WoS29 Europe PMC3
2012 Pepper, H., Kuan, K., & George, J. (2012). Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins. Organic Letters, 14(6), 1524-1527.
DOI Scopus18 WoS18 Europe PMC2
2011 Spence, J., & George, J. (2011). Structural reassignment of Cytosporolides A - C via biomimetic synthetic studies and reinterpretation of NMR data. Organic Letters, 13(19), 5318-5321.
DOI Scopus31 WoS32 Europe PMC10
2010 Hale, K., Manaviazar, S., & George, J. (2010). Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription. Chemical Communications, 46(23), 4021-4042.
DOI
2010 George, J., Baldwin, J., & Adlington, R. (2010). Enantiospecific, biosynthetically inspired formal total synthesis of (+)-Liphagal. Organic Letters, 12(10), 2394-2397.
DOI
2010 George, J., McArdle, M., Baldwin, J., & Adlington, R. (2010). Biomimetic rearrangements of simplified labdane diterpenoids. Tetrahedron, 66(33), 6321-6330.
DOI
2010 George, J., Hesse, M., Baldwin, J., & Adlington, R. (2010). Biomimetic synthesis of polycyclic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum. Organic Letters, 12(15), 3532-3535.
DOI Scopus50 WoS47 Europe PMC15
2009 Hale, K., Manaviazar, S., Lazarides, L., George, J., Walters, M., Cai, J., . . . El-Tanani, M. (2009). Synthesis of A83586C analogs with potent anticancer and beta-catenin/TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb. Organic Letters, 11(3), 737-740.
DOI
2009 Hale, K., Manaviazar, S., George, J., Walters, M., & Dalby, S. (2009). Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin. Organic Letters, 11(3), 733-736.
DOI
2008 George, J., & Adlington, R. (2008). A Synthetic Approach to the Communesins. Synlett, 2008(14), 2093-2096.
DOI
2008 Assem, E., Peh, K., Wan, B., Manaviazar, S., Walters, M., George, J., & Hale, K. (2008). Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflammation Research, 57(Supplement 1), 21-22.
DOI
2005 Dimopoulos, P., George, J., Tocher, D., Manaviazar, S., & Hale, K. (2005). Mechanistic studies on the O-directed free radical hydrostannation of disubstituted acetylenes with Ph3SnH and Et3B and on the iodination of allylically oxygenated alpha-triphenylstannylalkenes. Organic Letters, 7(24), 5377-5380.
DOI
2005 Dimopoulos, P., Athlan, A., Manaviazar, S., George, J., Walters, M., Lazarides, L., . . . Hale, K. (2005). O-directed free-radical hydrostannations of propargyl ethers, acetals, and alcohols with Ph3SnH and Et3B. Organic Letters, 7(24), 5369-5372.
DOI
Teaching
  • Aromatic chemistry (2nd year)
  • Bioorganic chemistry (2nd year)
  • Strategies and tactics of organic synthesis (3rd year)
  • Stereoselective synthesis (3rd year)
  • Reactive intermediates in organic synthesis (Honours)

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Co-Supervisor Chemotaxonomy of Nicotiana Species Doctor of Philosophy Doctorate Full Time Ms Samantha Dama
2018 Principal Supervisor Design, synthesis and applications of fluctional molecules Doctor of Philosophy Doctorate Full Time Mr Harshal Deepak Patel
2017 Principal Supervisor Biotinylation of Merochlorin A for Identification of Intracellular Targets and Total Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Miss Lauren Ashleigh Marie Murray
2017 Principal Supervisor Biometric Synthesis of Natural Products and Proposed Biosynthetic Intermediates for use in Enzymatic Studies Doctor of Philosophy Doctorate Full Time Ms Stefania Sassnink
2017 Principal Supervisor Biomimetic Total Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Miss Laura Jane Burchill
2017 Principal Supervisor Biomimetic Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Mr Aaron John Day
2016 Co-Supervisor Taking natures lead in the development of new bioactives Doctor of Philosophy Doctorate Full Time Mr Aniket Ravindra Kulkarni
2015 Co-Supervisor New Antibiotics Based on the Inhibition of BPL Doctor of Philosophy Doctorate Full Time Mr Kwang Jun Lee

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2018 Co-Supervisor Inhibition of Serine and Cysteine Proteases by Peptidomimetic Inhibitors Master of Philosophy Master Full Time Mr Nicholas Charles Schumann
2014 - 2017 Principal Supervisor Biomimetic Total Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Mr Hiu Chun Lam
2014 - 2018 Co-Supervisor Sensing in Biological Systems Doctor of Philosophy Doctorate Full Time Dr Georgina Maree Sylvia
2012 - 2016 Co-Supervisor Biomimetic Synthesis of Meroterpenoid Natural Products Using Dearomatization Strategies Doctor of Philosophy Doctorate Full Time Henry Patrick Pepper
2012 - 2016 Co-Supervisor Biomimetic Synthesis of Natural Products via Reactions of Ortho-Quinone Methides Doctor of Philosophy Doctorate Full Time Justin Thomas James Spence
2011 - 2015 Co-Supervisor PEPTIDOMIMETIC PROTEASE INHIBITORS: ACTIVITY AND MECHANISM OF INHIBITION Doctor of Philosophy Doctorate Part Time Dr Xiao Zhou Zhang
2011 - 2016 Co-Supervisor Biomimetic Synthesis of Marine Sponge Derived Natural Products Doctor of Philosophy Doctorate Full Time Mr Kevin Kuan
2011 - 2018 Co-Supervisor A Study on Side Chain Linked Peptides, Toward the Development of Talin Inhibitors using B3 Integrin Peptide Analogues Doctor of Philosophy Doctorate Part Time Miss Kelly Lee Keeling
Position
Senior Lecturer
Phone
83135494
Fax
8313 4380
Campus
North Terrace
Building
Badger, floor 1
Room Number
1 03
Org Unit
Chemistry

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