| 2025 |
Kirk, A. M., Stok, J. E., Wong, S. H., Coleman, T., Challinor, V. L., Herring, J. N., . . . De Voss, J. J. (2025). An Asynchronous, Concerted Mechanism for Cytochrome P450-Catalyzed Dehydrogenation: A Combined Deuterium Labeling and QM/MM Study. ACS Catalysis, 15(2), 1274-1286.
DOI Scopus2 WoS2 |
| 2025 |
Podgorski, M. N., Martínez-Castro, L., Bruning, J. B., Campbell, E. C., Maréchal, J. -D., & Bell, S. G. (2025). Investigating the Correlation between Product Release and Solvation in Cytochrome P450 Enzymes. ACS Catalysis, 15(4), 2867-2884.
DOI Scopus1 |
| 2025 |
Holroyd, D. L., Kumar, A., Vasquez, E., Masic, V., von Itzstein, M., Bruning, J. B., & Hansman, G. S. (2025). Antigenic structural analysis of bat and human norovirus protruding (P) domains. Journal of Virology, 99(4), e0197124-1-e0197124-6.
DOI WoS1 Europe PMC1 |
| 2025 |
Pederick, J. L., Kumar, A., Pukala, T. L., & Bruning, J. B. (2025). Functional and structural characterization of Staphylococcus aureus N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) reveals a redox-sensitive acetyltransferase activity.. Protein Sci, 34(4), e70111.
DOI Europe PMC1 |
| 2025 |
Lagonik, E., Page, E. C., Bruning, J. B., Eadie, L. N., Heatley, S. L., Greenwood, M., . . . White, D. L. (2025). Activity of STAMP inhibitors in ABL2 rearranged Acute Lymphoblastic Leukemia is dependent on the Abl2 SH3 domain. Blood Neoplasia, 2(3), 100109.
DOI Europe PMC1 |
| 2025 |
Doherty, D. Z., De Voss, J. J., Bruning, J. B., & Bell, S. G. (2025). Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction. Chemical Science, 16(24), 11110-11122.
DOI Scopus1 WoS1 Europe PMC1 |
| 2025 |
Pederick, J. L., & Bruning, J. B. (2025). Structural comparison of androstenediol recognition by the human estrogen receptor ligand binding domains. Molecular and Cellular Endocrinology, 607, 112588.
DOI |
| 2025 |
Haywood, J., Breese, K. J., McDougal, D. P., Verdonk, C., Partridge, A., Lo, A. F., . . . Mylne, J. S. (2025). Structural insights into a plant-conserved DHFR-TS reveal a selective herbicide target. Molecular Plant, 18(8), 1294-1309.
DOI |
| 2025 |
Holroyd, D. L., Bruning, J. B., von Itzstein, M., & Hansman, G. S. (2025). Structural constraints prevent a bat norovirus from binding to histo-blood group antigen co-factors.. J Virol, 99(9), e0099525.
DOI |
| 2025 |
Xie, J., Shen, K., Liang, W., Kuang, Z., Shrestha, R. K., Hanson, A. R., . . . Selth, L. A. (2025). Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.. Proceedings of the National Academy of Sciences of the United States of America, 122(42), e2509222122.
DOI |
| 2024 |
Lee, J. H. Z., Bruning, J. B., & Bell, S. G. (2024). An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase**. Chemistry: A European Journal, 30(8), e202303335-1-e202303335-8.
DOI Scopus2 WoS3 |
| 2024 |
Clayton-Cuch, D., Yu, L., McDougal, D., Burbidge, C. A., Bruning, J. B., Bradley, D., . . . Bulone, V. (2024). Biochemical and in silico characterization of glycosyltransferases from red sweet cherry (Prunus avium L.) reveals their broad specificity toward phenolic substrates. Food Chemistry: Molecular Sciences, 8, 100193.
DOI Scopus5 WoS5 Europe PMC1 |
| 2024 |
Mohamed, H., Child, S. A., Doherty, D. Z., Bruning, J. B., & Bell, S. G. (2024). Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum. Arch Biochem Biophys, 754, 109950-1-109950-11.
DOI Scopus2 WoS2 |
| 2024 |
Pederick, J. L., Frkic, R. L., McDougal, D. P., & Bruning, J. B. (2024). A structural basis for the activation of peroxisome proliferator-activated receptor gamma (PPARγ) by perfluorooctanoic acid (PFOA). Chemosphere, 354, 141723-1-141723-12.
DOI Scopus6 Europe PMC10 |
| 2024 |
Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., . . . Taglialatela, A. (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14(1), 16 pages.
DOI Scopus58 WoS63 Europe PMC64 |
| 2024 |
Podgorski, M. N., Akter, J., Churchman, L. R., Bruning, J. B., De Voss, J. J., & Bell, S. G. (2024). Engineering Peroxygenase Activity into Cytochrome P450 Monooxygenases through Modification of the Oxygen Binding Region. ACS Catalysis, 14(10), 7426-7443.
DOI Scopus11 WoS10 |
| 2024 |
Lee, J. H. Z., Coleman, T., Mclean, M. A., Podgorski, M. N., Hayball, E. F., Stone, I. S. J., . . . Bell, S. G. (2024). Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis, 14(11), 8958-8971.
DOI Scopus6 WoS6 Europe PMC2 |
| 2024 |
Giles, E., Heifets, A., Artía, Z., Inde, Z., Liu, Z., Zhang, Z., . . . Waggoner, S. N. (2024). Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z). Scientific Reports, 14(1).
DOI |
| 2024 |
Pederick, J. L., Vandborg, B. C., George, A., Bovermann, H., Boyd, J. M., Freundlich, J. S., & Bruning, J. B. (2024). Identification of cysteine metabolism regulator (CymR)-derived pentapeptides as nanomolar inhibitors of Staphylococcus aureus O-acetyl-ʟ-serine sulfhydrylase (CysK).. bioRxiv.
DOI |
| 2024 |
Pederick, J. L., Vandborg, B. C., George, A., Bovermann, H., Boyd, J. M., Freundlich, J. S., & Bruning, J. B. (2024). Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of Staphylococcus aureus O-Acetyl-l-serine Sulfhydrylase (CysK).. ACS Infect Dis, 11(1), 238-248.
DOI |
| 2023 |
Vandborg, B., Holroyd, D. L., Pukala, T., & Bruning, J. B. (2023). Production of recombinant human proliferating cellular nuclear antigen (PCNA) for structural and biophysical characterization. Protein Expression and Purification, 212, 1-7.
DOI Scopus2 WoS2 Europe PMC2 |
| 2023 |
Salaemae, W., Thompson, A. P., Gaiser, B. I., Lee, K. J., Huxley, M. T., Sumby, C. J., . . . Wegener, K. L. (2023). Fortuitous <i>In Vitro</i> Compound Degradation Produces a Tractable Hit against <i>Mycobacterium tuberculosis</i> Dethiobiotin Synthetase: A Cautionary Tale of What Goes In Does Not Always Come Out. ACS Chemical Biology, 18(9), 1985-1992.
DOI |
| 2023 |
Podgorski, M. N., Lee, J. H. Z., Harbort, J. S., Nguyen, G. T. H., Doherty, D. Z., Donald, W. A., . . . Bell, S. G. (2023). Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant. Journal of Inorganic Biochemistry, 249, 1-13.
DOI Scopus3 WoS3 |
| 2023 |
Becker, R., Pederick, J. L., Dawes, E. G., Bruning, J. B., & Abell, A. D. (2023). Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide D-alanine-D-alanine ligase inhibitors. Bioorganic and Medicinal Chemistry, 96, 14 pages.
DOI Scopus1 WoS1 |
| 2023 |
Vandborg, B. C., Horsfall, A. J., Pederick, J. L., Abell, A. D., & Bruning, J. B. (2023). Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus. Journal of Fungi, 9(11), 16 pages.
DOI |
| 2023 |
Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15.
DOI Scopus4 WoS4 Europe PMC3 |
| 2023 |
Pederick, J. L., Klose, J., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2023). <i>Escherichia coli</i> YgiC and YjfC Possess Peptide─Spermidine Ligase Activity. Biochemistry, 62(4), 899-911.
DOI Scopus5 WoS5 Europe PMC5 |
| 2023 |
Stachura, D. L., Nguyen, S., Polyak, S. W., Jovcevski, B., Bruning, J. B., & Abell, A. D. (2023). Structural Study of Potent Triazole-Based Inhibitors of <i>Staphylococcus aureus</i> Biotin Protein Ligase. ACS Medicinal Chemistry Letters, 14(3), 285-290.
DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
Ghith, A., Bruning, J. B., & Bell, S. G. (2023). The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.. Archives of biochemistry and biophysics, 737, 109554.
DOI Scopus3 WoS3 |
| 2023 |
Salaemae, W., Thompson, A., Gaiser, B., Lee, K. J., Huxley, M., Sumby, C., . . . Wegener, K. (2023). Fortuitous<i>in vitro</i>compound degradation produces a tractable hit against<i>Mycobacterium tuberculosis</i>dethiobiotin synthetase: a cautionary tale of what goes in, does not always come out.
DOI |
| 2023 |
Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., . . . Bell, S. G. (2023). Engineering C–C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222.
DOI Scopus19 WoS19 Europe PMC9 |
| 2023 |
Coleman, T., Podgorski, M. N., Doyle, M. L., Scaffidi-Muta, J. M., Campbell, E. C., Bruning, J. B., . . . Bell, S. G. (2023). Cytochrome P450-catalyzed oxidation of halogen-containing substrates.. Journal of Inorganic Biochemistry, 244, 12 pages.
DOI Scopus8 WoS8 Europe PMC5 |
| 2023 |
Frkic, R. L., Pederick, J. L., Horsfall, A. J., Jovcevski, B., Crame, E. E., Kowalczyk, W., . . . Bruning, J. B. (2023). PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.. ACS Chemical Biology, 18(5), 1115-1123.
DOI Scopus4 WoS4 Europe PMC9 |
| 2023 |
Ghith, A., Bruning, J. B., & Bell, S. G. (2023). The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum.. J Steroid Biochem Mol Biol, 231, 106317-1-106317-12.
DOI Scopus3 WoS4 Europe PMC1 |
| 2023 |
Pantong, W., Pederick, J. L., Maenpuen, S., Tinikul, R., Jayapalan, J. J., Jovcevski, B., . . . Salaemae, W. (2023). Biochemical and Structural Characterization of Meningococcal Methylenetetrahydrofolate Reductase. Protein Science, 32(6), e4654-1-e4654-13.
DOI Scopus1 WoS1 Europe PMC2 |
| 2023 |
Clayton-Cuch, D., McDougal, D., Schwerdt, J. G., Yu, L., Shirley, N., Bradley, D., . . . Bulone, V. (2023). Identification and characterisation of MdUGT78T2 as a galactosyltransferase with dual activity on flavonol and anthocyanidin substrates in red-skinned apple fruit (Malus domestica L.). Food Chemistry, 424, 12 pages.
DOI Scopus6 WoS4 Europe PMC4 |
| 2023 |
Podgorski, M. N., Keto, A. B., Coleman, T., Bruning, J. B., De Voss, J. J., Krenske, E. H., & Bell, S. G. (2023). The Oxidation of Oxygen and Sulfur-Containing Heterocycles by Cytochrome P450 Enzymes. Chemistry: A European Journal, 29(50), e202301371-1-e202301371-15.
DOI Scopus7 WoS7 Europe PMC1 |
| 2023 |
Horsfall, A. J., Chav, T., Pederick, J. L., Kikhtyak, Z., Vandborg, B. C., Kowalczyk, W., . . . Bruning, J. B. (2023). Designing Fluorescent Nuclear Permeable Peptidomimetics to Target Proliferating Cell Nuclear Antigen. Journal of Medicinal Chemistry, 66(15), 10354-10363.
DOI Scopus1 WoS1 Europe PMC1 |
| 2023 |
McDougal, D. P., Rajapaksha, H., Pederick, J. L., & Bruning, J. B. (2023). warpDOCK: Large-Scale Virtual Drug Discovery Using Cloud Infrastructure. ACS Omega, 8(32), 28932-29846.
DOI Scopus3 WoS2 Europe PMC2 |
| 2023 |
Pederick, J. L., Woolman, J. C., & Bruning, J. B. (2023). Comparative functional and structural analysis of Pseudomonas aeruginosa ᴅ-alanine-ᴅ-alanine ligase isoforms as prospective antibiotic targets.. The FEBS journal, 290(23), 5536-5553.
DOI Scopus1 WoS1 Europe PMC1 |
| 2022 |
Coleman, T., Kirk, A. M., Lee, J. H. Z., Doherty, D. Z., Bruning, J. B., Krenske, E. H., . . . Bell, S. G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12(2), 1258-1267.
DOI Scopus26 WoS25 |
| 2022 |
Podgorski, M. N., Harbort, J. S., Lee, J. H. Z., Nguyen, G. T. H., Bruning, J. B., Donald, W. A., . . . Bell, S. G. (2022). An altered heme environment in an engineered cytochrome P450 enzyme enables the switch from monooxygenase to peroxygenase activity. ACS Catalysis, 12(3), 1614-1625.
DOI Scopus45 WoS42 |
| 2022 |
Nguyen, S., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2022). Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus. Acta Crystallographica Section D Structural Biology, 78(2), 1-12.
DOI Scopus8 WoS7 Europe PMC5 |
| 2022 |
Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity.
DOI Europe PMC1 |
| 2022 |
Nguyen, S., Jovcevski, B., Truong, J. Q., Pukala, T. L., & Bruning, J. B. (2022). A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.. Proteins, 90(8), 1509-1520.
DOI Scopus1 WoS2 Europe PMC1 |
| 2022 |
Mohamed, H., Child, S. A., Bruning, J. B., & Bell, S. G. (2022). A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 221, 106097-1-106097-14.
DOI Scopus5 WoS5 Europe PMC1 |
| 2022 |
Button, E. L., Rossi, J. J., McDougal, D. P., Bruning, J. B., Peet, D., Bersten, D., . . . Whitelaw, M. (2022). Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.. The Biochemical journal, 479(13), 1441-1454.
DOI Scopus4 WoS3 Europe PMC3 |
| 2022 |
Downes, C. E., McClure, B. J., McDougal, D. P., Heatley, S. L., Bruning, J. B., Thomas, D., . . . White, D. L. (2022). JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies. Frontiers in Cell and Developmental Biology, 10, 1-34.
DOI Scopus27 WoS23 Europe PMC20 |
| 2022 |
Ghith, A., Doherty, D. Z., Bruning, J. B., Russell, R. A., De Voss, J. J., & Bell, S. G. (2022). The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8(8), 1606-1617.
DOI Scopus8 WoS8 Europe PMC2 |
| 2022 |
Pederick, J. L., Horsfall, A. J., Jovcevski, B., Klose, J., Abell, A. D., Pukala, T. L., & Bruning, J. B. (2022). Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism. Journal of Biological Chemistry, 298(10), 102392-1-102392-16.
DOI Scopus5 WoS6 Europe PMC4 |
| 2022 |
Coleman, T., Lee, J., Kirk, A. M., Doherty, D. Z., Podgorski, M. N., Pinidiya, D. K., . . . Bell, S. G. (2022). Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering. Chemistry: A European Journal, 28(67), 1-13.
DOI Scopus19 WoS16 Europe PMC9 |
| 2022 |
Podgorski, M. N., Coleman, T., Churchman, L. R., Bruning, J. B., De Voss, J. J., & Bell, S. G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28(72), 1-14.
DOI Scopus17 WoS16 Europe PMC9 |
| 2022 |
Coleman, T., Doherty, D. Z., Zhang, T., Podgorski, M. N., Qiao, R., Lee, J. H. Z., . . . Bell, S. G. (2022). Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation. Chemistry: An Asian Journal, 17(24), 1-15.
DOI Scopus12 WoS13 Europe PMC6 |
| 2022 |
Stachura, D. L., Nguyen, S., Polyak, S. W., Jovcevski, B., Bruning, J. B., & Abell, A. D. (2022). A New 1,2,3-Triazole Scaffold with Improved Potency against Staphylococcus aureus Biotin Protein Ligase. ACS Infectious Diseases, 8(12), 2579-2585.
DOI Scopus5 WoS4 Europe PMC3 |
| 2021 |
Pederick, J. L., & Bruning, J. B. (2021). An antimony-phosphomolybdate microassay of ATPase activity through the detection of inorganic phosphate. Analytical Biochemistry, 623, 114170.
DOI Scopus9 WoS10 Europe PMC5 |
| 2021 |
Horsfall, A. J., Chav, T., Bruning, J. B., & Abell, A. D. (2021). A turn-on fluorescent PCNA sensor. Bioorganic & Medicinal Chemistry Letters, 41, 128031-1-128031-6.
DOI Scopus2 WoS2 Europe PMC1 |
| 2021 |
Xie, J., De Poi, S. P., Humphrey, S. J., Hein, L. K., Bruning, J. B., Pan, W., . . . Proud, C. G. (2021). TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling. Cellular and Molecular Life Sciences, 78(8), 4035-4052.
DOI Scopus6 WoS6 Europe PMC5 |
| 2021 |
Truong, J. Q., Nguyen, S., Bruning, J. B., & Shearwin, K. E. (2021). Simplified heavy-atom derivatization of protein structures via co-crystallization with the MAD tetragon tetrabromoterephthalic acid. Acta Crystallographica Section F Structural Biology Communications, 77(5), 156-162.
DOI Scopus2 WoS2 Europe PMC2 |
| 2021 |
Tavakoli Shirazi, P., Eadie, L. N., Page, E. C., Heatley, S. L., Bruning, J. B., & White, D. L. (2021). Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia. Cancer Letters, 512, 28-37.
DOI Scopus11 WoS12 Europe PMC11 |
| 2021 |
Horsfall, A. J., Vandborg, B. A., Kowalczyk, W., Chav, T., Scanlon, D. B., Abell, A. D., & Bruning, J. B. (2021). Unlocking the PIP-box: A peptide library reveals interactions that drive high affinity binding to human PCNA.. The Journal of biological chemistry, 296, 1-16.
DOI Scopus14 WoS13 Europe PMC14 |
| 2021 |
Horsfall, A. J., McDougal, D. P., Scanlon, D. B., Bruning, J. B., & Abell, A. D. (2021). Approaches to introduce helical structure in cysteine-containing peptides with a bimane group. Chembiochem, 22(17), 2711-2720.
DOI Scopus4 WoS3 Europe PMC2 |
| 2021 |
Qu, Y., Zhang, B., Wang, Y., Yin, S., Pederick, J. L., Bruning, J. B., . . . Bi, J. (2021). Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope. Vaccine, 39(34), 4830-4841.
DOI Scopus8 WoS6 Europe PMC6 |
| 2021 |
Downes, C. E. J., McClure, B. J., Bruning, J. B., Page, E., Breen, J., Rehn, J., . . . White, D. L. (2021). Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia. NPJ Precision Oncology, 5(1), 1-13.
DOI Scopus21 WoS20 Europe PMC16 |
| 2021 |
Frkic, R. L., Richter, K., & Bruning, J. B. (2021). The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes.. Journal of Biological Chemistry, 297(3), 101030-1-101030-9.
DOI Scopus53 WoS51 Europe PMC36 |
| 2021 |
Marshall, A. C., & Bruning, J. B. (2021). Engineering potassium activation into biosynthetic thiolase. The Biochemical journal, 478(15), 3047-3062.
DOI Scopus2 WoS2 Europe PMC1 |
| 2021 |
Chao, R., Lau, I., Coleman, T., Churchman, L. R., Child, S. A., Lee, J. H. Z., . . . Bell, S. G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry: A European Journal, 27(59), 14765-14777.
DOI Scopus9 WoS9 Europe PMC4 |
| 2021 |
Horsfall, A. J., Vandborg, B., Kikhtyak, Z., Scanlon, D. B., Tilley, W. D., Hickey, T. E., . . . Abell, A. D. (2021). A cell permeable bimane-constrained PCNA-interacting peptide. RSC Chemical Biology, 2(5), 1499-1508.
DOI Scopus5 WoS5 Europe PMC2 |
| 2021 |
Schumann, N. C., Lee, K. J., Thompson, A. P., Salaemae, W., Pederick, J. L., Avery, T., . . . Abell, A. D. (2021). Inhibition of Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS): toward next-generation antituberculosis agents. ACS Chemical Biology, 16(11), 2339-2347.
DOI Scopus7 WoS7 Europe PMC7 |
| 2021 |
Podgorski, M. N., Coleman, T., Giang, P. D., Wang, C. R., Bruning, J. B., Bernhardt, P. V., . . . Bell, S. G. (2021). To be, or not to be, an Inhibitor: a comparison of azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61(1), 236-245.
DOI Scopus14 WoS15 Europe PMC6 |
| 2021 |
Slynko, I., Nguyen, S., Hamilton, E. M. C., Wisse, L. E., de Esch, I. J. P., de Graaf, C., . . . van der Knaap, M. S. (2021). Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.. Molecular genetics & genomic medicine, 9(3), 1-15.
DOI Scopus24 WoS22 Europe PMC22 |
| 2021 |
Nguyen, S., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2021). Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase.. The FEBS journal, 288(7), 2398-2417.
DOI Scopus8 WoS8 Europe PMC6 |
| 2021 |
Nguyen, S., Truong, J. Q., & Bruning, J. B. (2021). Targeting Unconventional Pathways in Pursuit of Novel Antifungals.. Front Mol Biosci, 7, 1-16.
DOI Scopus18 WoS14 Europe PMC10 |
| 2021 |
Truong, J. Q., Nguyen, S., Bruning, J. B., & Shearwin, K. E. (2021). Derivatization of protein crystals with I3C using random microseed matrix screening. Journal of Visualized Experiments, 2021(167), 1-19.
DOI WoS1 Europe PMC1 |
| 2021 |
Coleman, T., Kirk, A. M., Chao, R. R., Podgorski, M. N., Harbort, J. S., Churchman, L. R., . . . Bell, S. G. (2021). Understanding the Mechanistic Requirements for Efficient and Stereoselective Alkene Epoxidation by a Cytochrome P450 Enzyme. ACS Catalysis, 11(4), 1995-2010.
DOI Scopus48 WoS43 |
| 2020 |
Jia, Y., Shen, G., Nguyen, S., Zhang, Y., Huang, K. -S., Ho, H. -Y., . . . Wang, W. -L. (2020). Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity.
DOI Europe PMC8 |
| 2020 |
Horsfall, A. J., Abell, A. D., & Bruning, J. (2020). Targeting PCNA with peptide mimetics for therapeutic purposes. ChemBioChem, 21(4), 442-450.
DOI Scopus33 WoS29 Europe PMC25 |
| 2020 |
Podgorski, M. N., Coleman, T., Chao, R. R., De Voss, J. J., Bruning, J. B., & Bell, S. G. (2020). Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. Journal of Inorganic Biochemistry, 203, 110913-1-110913-13.
DOI Scopus30 WoS30 Europe PMC19 |
| 2020 |
Podgorski, M. N., Harbort, J. S., Coleman, T., Stok, J. E., Yorke, J. A., Wong, L. -L., . . . Bell, S. G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59(9), 1038-1050.
DOI Scopus26 WoS25 Europe PMC15 |
| 2020 |
Coleman, T., Stok, J. E., Podgorski, M. N., Bruning, J. B., De Voss, J. J., & Bell, S. G. (2020). Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry, 25(4), 583-596.
DOI Scopus36 WoS39 Europe PMC21 |
| 2020 |
Pederick, J. L., Thompson, A. P., Bell, S. G., & Bruning, J. B. (2020). D-alanine-D-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.. Journal of Biological Chemistry, 295(23), 7894-7904.
DOI Scopus29 WoS25 Europe PMC23 |
| 2020 |
Child, S. A., Ghith, A., Bruning, J. B., & Bell, S. G. (2020). A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis. Journal of Inorganic Biochemistry, 209, 1-12.
DOI Scopus15 WoS14 Europe PMC5 |
| 2020 |
Xie, J., De Poi, S., Humphrey, S., Hein, L., Bruning, J., Pan, W., . . . Proud, C. (2020). TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming.
DOI |
| 2019 |
Truong, J. Q., Panjikar, S., Shearwin-Whyatt, L., Bruning, J. B., & Shearwin, K. E. (2019). Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68. Acta crystallographica Section D. Structural biology, 75(7), 670-681.
DOI Scopus3 WoS3 Europe PMC3 |
| 2019 |
Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., . . . Abell, A. D. (2019). Sulfonamide-based inhibitors of biotin protein ligase as new antibiotic leads. ACS Chemical Biology, 14(9), 1990-1997.
DOI Scopus9 WoS8 Europe PMC4 |
| 2019 |
Jia, Y., Burbidge, C. A., Sweetman, C., Schutz, E., Soole, K., Jenkins, C., . . . Ford, C. M. (2019). An aldo-keto reductase with 2-keto- L-gulonate reductase activity functions in L-tartaric acid biosynthesis from vitamin C in Vitis vinifera. The Journal of biological chemistry, 294(44), 15932-15946.
DOI Scopus24 WoS23 Europe PMC17 |
| 2019 |
Schumann, N. C., Bruning, J., Marshall, A. C., & Abell, A. D. (2019). The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin. Bioorganic and Medicinal Chemistry Letters, 29(3), 396-399.
DOI Scopus3 WoS3 Europe PMC1 |
| 2019 |
Marshall, A. C., Kidd, S. E., Lamont-Friedrich, S. J., Arentz, G., Hoffmann, P., Coad, B. R., & Bruning, J. B. (2019). Structure, mechanism, and inhibition of aspergillus fumigatus thioredoxin reductase. Antimicrobial Agents and Chemotherapy, 63(3), 1-15.
DOI Scopus31 WoS30 Europe PMC25 |
| 2019 |
Elzahhar, P. A., Alaaeddine, R., Ibrahim, T. M., Nassra, R., Ismail, A., Chua, B. S. K., . . . Belal, A. S. F. (2019). Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones. European Journal of Medicinal Chemistry, 167, 562-582.
DOI Scopus42 WoS41 Europe PMC24 |
| 2019 |
Child, S. A., Flint, K. L., Bruning, J. B., & Bell, S. G. (2019). The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum. Biochimica et Biophysica Acta - General Subjects, 1863(5), 925-934.
DOI Scopus4 WoS3 Europe PMC2 |
| 2019 |
Chang, M. R., Ciesla, A., Strutzenberg, T. S., Novick, S. J., He, Y., Garcia-Ordonez, R. D., . . . Griffin, P. R. (2019). Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways. ACS Chemical Biology, 14(5), 1051-1062.
DOI Scopus8 WoS8 Europe PMC7 |
| 2018 |
Marshall, A., Keiller, B., Pederick, J., Abell, A., & Bruning, J. (2018). Crystal structure of bovine alpha-chymotrypsin in space group P65. Crystals, 8(12), 460.
DOI Scopus3 WoS3 |
| 2018 |
Frkic, R. L., Chua, B. S., Shin, Y., Pascal, B. D., Novick, S. J., Kamenecka, T. M., . . . Bruning, J. B. (2018). Structural and dynamic elucidation of a non-acid PPARγ partial agonist: SR1988. Nuclear Receptor Research, 5, 101350-1-101350-12.
DOI Europe PMC5 |
| 2018 |
Child, S., Naumann, E., Bruning, J., & Bell, S. (2018). Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum. The Biochemical Journal, 475(4), 705-722.
DOI Scopus14 WoS14 Europe PMC5 |
| 2018 |
Marshall, A., Bond, C., & Bruning, J. (2018). Structure of Aspergillus fumigatus Cytosolic thiolase: trapped tetrahedral reaction intermediates and activation by monovalent cations. ACS Catalysis, 8(3), 1973-1989.
DOI Scopus5 WoS5 |
| 2018 |
Coleman, T., Wong, S., Podgorski, M., Bruning, J., De Voss, J., & Bell, S. (2018). Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyses heteroatom dealkylations, sulfoxidation and amide and cyclic hemiacetal formation. ACS Catalysis, 8(7), 5915-5927.
DOI Scopus36 WoS36 |
| 2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. (2018). Rational design of a 310-helical PIP-box mimetic targeting PCNA - the human sliding clamp. Chemistry - A European Journal, 24(44), 11325-11331.
DOI Scopus16 WoS15 Europe PMC12 |
| 2018 |
Thompson, A., Wegener, K., Booker, G., Polyak, S., & Bruning, J. (2018). Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallographica Section D: Structural Biology, 74(10), 965-972.
DOI Scopus4 WoS4 Europe PMC2 |
| 2018 |
Frkic, R. L., Marshall, A. C., Blayo, A. -L., Pukala, T. L., Kamenecka, T. M., Griffin, P. R., & Bruning, J. B. (2018). PPARγ in complex with an antagonist and inverse agonist: a tumble and trap mechanism of the activation helix. iScience, 5, 69-79.
DOI Scopus58 WoS55 Europe PMC48 |
| 2018 |
Zheng, J., Corzo, C., Chang, M., Shang, J., Lam, V., Brust, R., . . . Griffin, P. (2018). Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism. Structure, 26(11), 1431-1439.
DOI Scopus26 WoS26 Europe PMC25 |
| 2018 |
Thompson, A. P., Salaemae, W., Pederick, J. L., Abell, A. D., Booker, G. W., Bruning, J. B., . . . Polyak, S. W. (2018). Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. ACS Catalysis, 8(11), 10774-10783.
DOI Scopus7 WoS6 |
| 2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. B. (2018). Front Cover: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018). Chemistry – A European Journal, 24(44), 11234.
DOI |
| 2017 |
Stevens, T., Song, S., Bruning, J., Choo, A., & Baxter, S. (2017). Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor. Insect Biochemistry and Molecular Biology, 80, 61-70.
DOI Scopus48 WoS45 Europe PMC36 |
| 2017 |
Marshall, A., Kroker, A., Murray, L., Gronthos, K., Rajapaksha, H., Wegener, K., & Bruning, J. (2017). Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21. FEBS Journal, 284(6), 985-1002.
DOI Scopus11 WoS11 Europe PMC9 |
| 2017 |
Sternicki, L., Wegener, K., Bruning, J., Booker, G., & Polyak, S. (2017). Mechanisms governing precise protein biotinylation. Trends in Biochemical Sciences, 42(5), 383-394.
DOI Scopus23 WoS21 Europe PMC11 |
| 2017 |
Rajapaksha, H., Bhatia, H., Wegener, K., Petrovsky, N., & Bruning, J. (2017). X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs. Biochimica et Biophysica Acta - General Subjects, 1861(8), 1981-1991.
DOI Scopus18 WoS19 Europe PMC12 |
| 2017 |
Frkic, R., He, Y., Rodriguez, B., Chang, M., Kuruvilla, D., Ciesla, A., . . . Bruning, J. (2017). Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. Journal of Medicinal Chemistry, 60(11), 4584-4593.
DOI Scopus25 WoS23 Europe PMC18 |
| 2017 |
Zheng, J., Chang, M., Stites, R., Wang, Y., Bruning, J., Pascal, B., . . . Griffin, P. (2017). HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nature Communications, 8(1), 923-1-923-13.
DOI Scopus36 WoS33 Europe PMC33 |
| 2016 |
Van Marrewijk, L., Polyak, S., Hijnen, M., Kuruvilla, D., Chang, M., Shin, Y., . . . Bruning, J. (2016). SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism. ACS Chemical Biology, 11(1), 273-283.
DOI Scopus34 WoS32 Europe PMC22 |
| 2016 |
Zhang, X., Bruning, J., George, J., & Abell, A. (2016). A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Organic and Biomolecular Chemistry, 14(29), 6970-6978.
DOI Scopus13 WoS13 Europe PMC4 |
| 2016 |
Stechschulte, L., Czernik, P., Rotter, Z., Tausif, F., Corzo, C., Marciano, D., . . . Lecka-Czernik, B. (2016). PPARG Post-translational modifications regulate bone formation and bone resorption. EBioMedicine, 10, 174-184.
DOI Scopus74 WoS72 Europe PMC65 |
| 2015 |
Jia, Y., Wong, D., Sweetman, C., Bruning, J., & Ford, C. (2015). New insights into the evolutionary history of plant sorbitol dehydrogenase. BMC Plant Biology, 15(1), 101-1-101-23.
DOI Scopus35 WoS32 Europe PMC21 |
| 2015 |
Kroker, A., & Bruning, J. (2015). p21 exploits residue Tyr151 as a tether for high-affinity PCNA binding. Biochemistry, 54(22), 3483-3493.
DOI Scopus27 WoS26 Europe PMC23 |
| 2015 |
Coleman, T., Chao, R., Bruning, J., De Voss, J., & Bell, S. (2015). CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives. RSC Advances, 5(64), 52007-52018.
DOI Scopus35 WoS34 |
| 2015 |
Marciano, D., Kuruvilla, D., Boregowda, S., Asteian, A., Hughes, T., Garcia-Ordonez, R., . . . Griffin, P. (2015). Pharmacological repression of PPARγ promotes osteogenesis. Nature Communications, 6(1), 7443-1-7443-7.
DOI Scopus106 WoS105 Europe PMC93 |
| 2015 |
Kojetin, D., Matta-Camacho, E., Hughes, T., Srinivasan, S., Nwachukwu, J., Cavett, V., . . . Nettles, K. (2015). Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nature Communications, 6(1), 8013-1-8013-14.
DOI Scopus109 WoS106 Europe PMC92 |
| 2015 |
Kroker, A., & Bruning, J. (2015). Review of the structural and dynamic mechanisms of PPAR γ partial agonism. PPAR Research, 2015, 816856-1-816856-15.
DOI Scopus175 WoS161 Europe PMC132 |
| 2014 |
Chua, K., Pietsch, M., Zhang, X., Hautmann, S., Chan, H., Bruning, J., . . . Abell, A. (2014). Macrocyclic protease inhibitors with reduced peptide character. Angewandte Chemie International Edition, 53(30), 7828-7831.
DOI Scopus24 WoS23 Europe PMC14 |
| 2014 |
Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
DOI Scopus9 WoS8 Europe PMC10 |
| 2014 |
Bersten, D., Bruning, J., Peet, D., & Whitelaw, M. (2014). Human variants in the Neuronal Basic Helix-Loop-Helix/ Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One, 9(1), e85768-1-e85768-11.
DOI Scopus21 WoS20 Europe PMC21 |
| 2014 |
Reddy, M., Breda, A., Bruning, J., Sherekar, M., Valluru, S., Thurman, C., . . . Sacchettini, J. (2014). Structure, activity, and inhibition of the carboxyltransferase β-Subunit of acetyl coenzyme a carboxylase (AccD6) from mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 58(10), 6122-6132.
DOI Scopus21 WoS19 Europe PMC16 |
| 2013 |
Mosser, R., Reddy, M., Bruning, J., Sacchettini, J., & Reinhart, G. (2013). Redefining the role of the quaternary shift in bacillus stearothermophilus phosphofructokinase. Biochemistry, 52(32), 5421-5429.
DOI Scopus9 WoS9 Europe PMC11 |
| 2013 |
Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D., . . . Froguel, P. (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. Journal of Clinical Investigation, 123(7), 3037-3041.
DOI Scopus115 WoS102 Europe PMC92 |
| 2013 |
Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
DOI Scopus138 WoS115 Europe PMC111 |
| 2012 |
Mosser, R., Reddy, M., Bruning, J., Sacchettini, J., & Reinhart, G. (2012). Structure of the apo form of Bacillus Stearothermophilus Phosphofructokinase. Biochemistry, 51(3), 769-775.
DOI Scopus9 WoS9 Europe PMC8 |
| 2011 |
Bruning, J., Murillo, A., Chacon, O., Barletta, R., & Sacchettini, J. (2011). Structure of the Mycobacterium tuberculosis D-alanine:D-alanine Ligase, a target of the antituberculosis drug D-Cycloserine. Antimicrobial Agents and Chemotherapy, 55(1), 291-301.
DOI Scopus129 WoS118 Europe PMC95 |
| 2011 |
Zhang, J., Chalmers, M., Stayrook, K., Burris, L., Wang, Y., Busby, S., . . . Griffin, P. (2011). DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nature Structural and Molecular Biology, 18(5), 556-563.
DOI Scopus173 WoS158 Europe PMC148 |
| 2011 |
Chim, N., Habel, J., Johnston, J., Krieger, I., Miallau, L., Sankaranarayanan, R., . . . Goulding, C. (2011). The TB structural genomics consortium: a decade of progress. Tuberculosis, 91(2), 155-172.
DOI Scopus38 WoS33 Europe PMC31 |
| 2011 |
Choi, J., Banks, A., Kamenecka, T., Busby, S., Chalmers, M., Kumar, N., . . . Griffin, P. (2011). Anti-diabetic actions of a non-agonist PPARgamma ligand that blocks Cdk5-mediated phosphorylation. Nature, 477(7365), 477-481.
DOI Scopus476 WoS442 Europe PMC401 |
| 2010 |
Bruning, J., Parent, A., Gil, G., Zhao, M., Nowak, J., Pace, M., . . . Nettles, K. (2010). Coupling of receptor conformation and ligand orientation determine graded activity. Nature Chemical Biology, 6(11), 837-843.
DOI Scopus124 WoS121 Europe PMC93 |
| 2009 |
Reddy, M., Palaninathan, S., Bruning, J., Thurman, C., Smith, D., & Sacchettini, J. (2009). Structural insights into the mechanism of the allosteric transitions of Mycobacterium Tuberculosis cAMP receptor protein. Journal of Biological Chemistry, 284(52), 36581-36591.
DOI Scopus37 WoS32 Europe PMC29 |
| 2008 |
Nettles, K., Bruning, J., Gil, G., Nowak, J., Sharma, S., Hahm, J., . . . Greene, G. (2008). NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nature Chemical Biology, 4(4), 241-247.
DOI Scopus137 WoS138 Europe PMC116 |
| 2008 |
Dai, S., Chalmers, M., Bruning, J., Bramlett, K., Osborne, H., Montrose-Rafizadeh, C., . . . Griffin, P. (2008). Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proceedings of the National Academy of Sciences of the United States of America, 105(20), 7171-7176.
DOI Scopus82 WoS70 Europe PMC63 |
| 2007 |
Nettles, K., Bruning, J., Gil, G., O'Neill, E., Nowak, J., Hughs, A., . . . Greene, G. (2007). Structural plasticity in the oestrogen receptor ligand-binding domain. EMBO Reports, 8(6), 563-568.
DOI Scopus120 WoS118 Europe PMC96 |
| 2007 |
Zhou, H., Nettles, K., Bruning, J., Kim, Y., Joachimiak, A., Sharma, S., . . . Katzenellenbogen, J. (2007). Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands. Chemistry & Biology, 14(6), 659-669.
DOI Scopus63 WoS63 Europe PMC44 |
| 2007 |
Bruning, J., Chalmers, M., Prasad, S., Busby, S., Kamenecka, T., He, Y., . . . Griffin, P. (2007). Partial agonists activate PPARγ using a helix 12 independent mechanism. Structure, 15(10), 1258-1271.
DOI Scopus335 WoS324 Europe PMC278 |
| 2004 |
Bruning, J. B., & Shamoo, Y. (2004). Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1. Structure, 12(12), 2209-2219.
DOI Scopus182 WoS181 Europe PMC168 |
| - |
Coleman, T., Podgorski, M. N., Doyle, M. L., Scaffidi-Muta, J. M., Campbell, E. C., Bruning, J. B., . . . Bell, S. (2023). Cytochrome P450-Catalyzed Oxidation of Halogen-Containing Substrates. SSRN Electronic Journal.
DOI |
