| 2024 |
Lee, J. H. Z., Bruning, J. B., & Bell, S. G. (2024). An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase**. Chemistry - A European Journal, 30(8), 8 pages.
DOI |
| 2024 |
Clayton-Cuch, D., Yu, L., McDougal, D., Burbidge, C. A., Bruning, J. B., Bradley, D., . . . Bulone, V. (2024). Biochemical and in silico characterization of glycosyltransferases from red sweet cherry (Prunus avium L.) reveals their broad specificity toward phenolic substrates. Food Chemistry: Molecular Sciences, 8, 11 pages.
DOI |
| 2024 |
Mohamed, H., Child, S. A., Doherty, D. Z., Bruning, J. B., & Bell, S. G. (2024). Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum. Archives of Biochemistry and Biophysics, 754, 109950.
DOI |
| 2024 |
Pederick, J. L., Frkic, R. L., McDougal, D. P., & Bruning, J. B. (2024). A structural basis for the activation of peroxisome proliferator-activated receptor gamma (PPARγ) by perfluorooctanoic acid (PFOA). Chemosphere, 354, 141723.
DOI |
| 2023 |
Vandborg, B., Holroyd, D. L., Pukala, T., & Bruning, J. B. (2023). Production of recombinant human proliferating cellular nuclear antigen (PCNA) for structural and biophysical characterization. Protein Expression and Purification, 212, 1-7.
DOI Scopus1 Europe PMC1 |
| 2023 |
Salaemae, W., Thompson, A. P., Gaiser, B. I., Lee, K. J., Huxley, M. T., Sumby, C. J., . . . Wegener, K. L. (2023). Fortuitous <i>In Vitro</i> Compound Degradation Produces a Tractable Hit against <i>Mycobacterium tuberculosis</i> Dethiobiotin Synthetase: A Cautionary Tale of What Goes In Does Not Always Come Out. ACS Chemical Biology, 18(9), 1985-1992.
DOI |
| 2023 |
Podgorski, M. N., Lee, J. H. Z., Harbort, J. S., Nguyen, G. T. H., Doherty, D. Z., Donald, W. A., . . . Bell, S. G. (2023). Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant. Journal of Inorganic Biochemistry, 249, 1-13.
DOI |
| 2023 |
Becker, R., Pederick, J. L., Dawes, E. G., Bruning, J. B., & Abell, A. D. (2023). Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide D-alanine-D-alanine ligase inhibitors. Bioorganic and Medicinal Chemistry, 96, 14 pages.
DOI |
| 2023 |
Vandborg, B. C., Horsfall, A. J., Pederick, J. L., Abell, A. D., & Bruning, J. B. (2023). Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus. Journal of Fungi, 9(11), 16 pages.
DOI |
| 2023 |
Henderson, S. W., Nakayama, Y., Whitelaw, M. L., Bruning, J. B., Anderson, P. A., Tyerman, S. D., . . . Yool, A. J. (2023). Proteoliposomes reconstituted with human aquaporin-1 reveal novel single ion channel properties. Biophysical Reports, 3(1), 100100-1-100100-15.
DOI Scopus2 WoS2 Europe PMC1 |
| 2023 |
Pederick, J. L., Klose, J., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2023). <i>Escherichia coli</i> YgiC and YjfC Possess Peptide─Spermidine Ligase Activity. Biochemistry, 62(4), 899-911.
DOI Scopus2 |
| 2023 |
Stachura, D. L., Nguyen, S., Polyak, S. W., Jovcevski, B., Bruning, J. B., & Abell, A. D. (2023). Structural Study of Potent Triazole-Based Inhibitors of <i>Staphylococcus aureus</i> Biotin Protein Ligase. ACS Medicinal Chemistry Letters, 14(3), 285-290.
DOI |
| 2023 |
Ghith, A., Bruning, J. B., & Bell, S. G. (2023). The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.. Archives of biochemistry and biophysics, 737, 109554.
DOI Scopus2 WoS1 |
| 2023 |
Salaemae, W., Thompson, A., Gaiser, B., Lee, K. J., Huxley, M., Sumby, C., . . . Wegener, K. (2023). Fortuitous<i>in vitro</i>compound degradation produces a tractable hit against<i>Mycobacterium tuberculosis</i>dethiobiotin synthetase: a cautionary tale of what goes in, does not always come out.
DOI |
| 2023 |
Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., . . . Bell, S. G. (2023). Engineering C–C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222.
DOI Scopus7 WoS2 |
| 2023 |
Coleman, T., Podgorski, M. N., Doyle, M. L., Scaffidi-Muta, J. M., Campbell, E. C., Bruning, J. B., . . . Bell, S. G. (2023). Cytochrome P450-catalyzed oxidation of halogen-containing substrates.. Journal of Inorganic Biochemistry, 244, 12 pages.
DOI Scopus2 WoS1 |
| 2023 |
Frkic, R. L., Pederick, J. L., Horsfall, A. J., Jovcevski, B., Crame, E. E., Kowalczyk, W., . . . Bruning, J. B. (2023). PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. ACS Chemical Biology, 18(5), 1115-1123.
DOI Scopus1 |
| 2023 |
Ghith, A., Bruning, J. B., & Bell, S. G. (2023). The oxidation of cholesterol derivatives by the CYP124 and CYP142 enzymes from Mycobacterium marinum.. J Steroid Biochem Mol Biol, 231, 106317-1-106317-12.
DOI Scopus1 Europe PMC1 |
| 2023 |
Pantong, W., Pederick, J. L., Maenpuen, S., Tinikul, R., Jayapalan, J. J., Jovcevski, B., . . . Salaemae, W. (2023). Biochemical and Structural Characterization of Meningococcal Methylenetetrahydrofolate Reductase. Protein Science, 32(6), 13 pages.
DOI Europe PMC1 |
| 2023 |
Clayton-Cuch, D., McDougal, D., Schwerdt, J. G., Yu, L., Shirley, N., Bradley, D., . . . Bulone, V. (2023). Identification and characterisation of MdUGT78T2 as a galactosyltransferase with dual activity on flavonol and anthocyanidin substrates in red-skinned apple fruit (Malus domestica L.). Food Chemistry, 424, 12 pages.
DOI Scopus2 Europe PMC2 |
| 2023 |
Podgorski, M. N., Keto, A. B., Coleman, T., Bruning, J. B., De Voss, J. J., Krenske, E. H., & Bell, S. G. (2023). The Oxidation of Oxygen and Sulfur-Containing Heterocycles by Cytochrome P450 Enzymes. Chemistry: A European Journal, 29(50), e202301371-1-e202301371-15.
DOI Scopus1 |
| 2023 |
Horsfall, A. J., Chav, T., Pederick, J. L., Kikhtyak, Z., Vandborg, B. C., Kowalczyk, W., . . . Bruning, J. B. (2023). Designing Fluorescent Nuclear Permeable Peptidomimetics to Target Proliferating Cell Nuclear Antigen. Journal of Medicinal Chemistry, 66(15), 10354-10363.
DOI |
| 2023 |
McDougal, D. P., Rajapaksha, H., Pederick, J. L., & Bruning, J. B. (2023). warpDOCK: Large-Scale Virtual Drug Discovery Using Cloud Infrastructure. ACS Omega, 8(32), 28932-29846.
DOI Scopus1 |
| 2023 |
Pederick, J. L., Woolman, J. C., & Bruning, J. B. (2023). Comparative functional and structural analysis of Pseudomonas aeruginosa d-alanine–d-alanine ligase isoforms as prospective antibiotic targets. FEBS Journal, 290(23), 5536-5553.
DOI |
| 2022 |
Coleman, T., Kirk, A. M., Lee, J. H. Z., Doherty, D. Z., Bruning, J. B., Krenske, E. H., . . . Bell, S. G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12(2), 1258-1267.
DOI Scopus14 WoS11 |
| 2022 |
Podgorski, M. N., Harbort, J. S., Lee, J. H. Z., Nguyen, G. T. H., Bruning, J. B., Donald, W. A., . . . Bell, S. G. (2022). An altered heme environment in an engineered cytochrome P450 enzyme enables the switch from monooxygenase to peroxygenase activity. ACS Catalysis, 12(3), 1614-1625.
DOI Scopus28 WoS17 |
| 2022 |
Nguyen, S., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2022). Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus. Acta Crystallographica Section D Structural Biology, 78(2), 1-12.
DOI Scopus2 WoS2 Europe PMC2 |
| 2022 |
Bersten, D. C., Sullivan, A. E., McDougal, D., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., . . . Whitelaw, M. L. (2022). Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity.
DOI |
| 2022 |
Nguyen, S., Jovcevski, B., Truong, J. Q., Pukala, T. L., & Bruning, J. B. (2022). A structural model of the human plasminogen and Aspergillus fumigatus enolase complex.. Proteins, 90(8), 1509-1520.
DOI |
| 2022 |
Mohamed, H., Child, S. A., Bruning, J. B., & Bell, S. G. (2022). A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 221, 106097-1-106097-14.
DOI Scopus4 WoS3 Europe PMC1 |
| 2022 |
Button, E. L., Rossi, J. J., McDougal, D. P., Bruning, J. B., Peet, D., Bersten, D., . . . Whitelaw, M. (2022). Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.. The Biochemical journal, 479(13), 1441-1454.
DOI Scopus1 |
| 2022 |
Downes, C. E., McClure, B. J., McDougal, D. P., Heatley, S. L., Bruning, J. B., Thomas, D., . . . White, D. L. (2022). JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies. Frontiers in Cell and Developmental Biology, 10, 1-34.
DOI Scopus13 WoS8 Europe PMC6 |
| 2022 |
Ghith, A., Doherty, D. Z., Bruning, J. B., Russell, R. A., De Voss, J. J., & Bell, S. G. (2022). The Structures of the Steroid Binding CYP142 Cytochrome P450 Enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8(8), 1606-1617.
DOI Scopus6 WoS3 Europe PMC1 |
| 2022 |
Pederick, J. L., Horsfall, A. J., Jovcevski, B., Klose, J., Abell, A. D., Pukala, T. L., & Bruning, J. B. (2022). Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism. Journal of Biological Chemistry, 298(10), 1-16.
DOI Scopus1 WoS1 |
| 2022 |
Coleman, T., Lee, J., Kirk, A. M., Doherty, D. Z., Podgorski, M. N., Pinidiya, D. K., . . . Bell, S. G. (2022). Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering. Chemistry: A European Journal, 28(67), 1-13.
DOI Scopus7 WoS2 Europe PMC2 |
| 2022 |
Podgorski, M. N., Coleman, T., Churchman, L. R., Bruning, J. B., De Voss, J. J., & Bell, S. G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28(72), 1-14.
DOI Scopus9 WoS5 Europe PMC4 |
| 2022 |
Coleman, T., Doherty, D. Z., Zhang, T., Podgorski, M. N., Qiao, R., Lee, J. H. Z., . . . Bell, S. G. (2022). Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation. Chemistry: An Asian Journal, 17(24), 1-15.
DOI Scopus6 WoS4 Europe PMC2 |
| 2022 |
Stachura, D. L., Nguyen, S., Polyak, S. W., Jovcevski, B., Bruning, J. B., & Abell, A. D. (2022). A New 1,2,3-Triazole Scaffold with Improved Potency against Staphylococcus aureus Biotin Protein Ligase. ACS Infectious Diseases, 8(12), 2579-2585.
DOI Scopus3 WoS2 Europe PMC1 |
| 2021 |
Pederick, J. L., & Bruning, J. B. (2021). An antimony-phosphomolybdate microassay of ATPase activity through the detection of inorganic phosphate. Analytical Biochemistry, 623, 114170.
DOI Scopus7 WoS4 Europe PMC2 |
| 2021 |
Horsfall, A. J., Chav, T., Bruning, J. B., & Abell, A. D. (2021). A turn-on fluorescent PCNA sensor. Bioorganic & Medicinal Chemistry Letters, 41, 128031-1-128031-6.
DOI |
| 2021 |
Xie, J., De Poi, S. P., Humphrey, S. J., Hein, L. K., Bruning, J. B., Pan, W., . . . Proud, C. G. (2021). TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling. Cellular and Molecular Life Sciences, 78(8), 4035-4052.
DOI Scopus5 WoS2 Europe PMC2 |
| 2021 |
Truong, J. Q., Nguyen, S., Bruning, J. B., & Shearwin, K. E. (2021). Simplified heavy-atom derivatization of protein structures via co-crystallization with the MAD tetragon tetrabromoterephthalic acid. Acta Crystallographica Section F Structural Biology Communications, 77(5), 156-162.
DOI Scopus2 WoS2 Europe PMC2 |
| 2021 |
Tavakoli Shirazi, P., Eadie, L. N., Page, E. C., Heatley, S. L., Bruning, J. B., & White, D. L. (2021). Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia. Cancer Letters, 512, 28-37.
DOI Scopus8 WoS8 Europe PMC4 |
| 2021 |
Horsfall, A. J., Vandborg, B. A., Kowalczyk, W., Chav, T., Scanlon, D. B., Abell, A. D., & Bruning, J. B. (2021). Unlocking the PIP-box: A peptide library reveals interactions that drive high affinity binding to human PCNA.. The Journal of biological chemistry, 296, 1-16.
DOI Scopus8 WoS6 Europe PMC6 |
| 2021 |
Horsfall, A. J., McDougal, D. P., Scanlon, D. B., Bruning, J. B., & Abell, A. D. (2021). Approaches to introduce helical structure in cysteine-containing peptides with a bimane group. Chembiochem, 22(17), 2711-2720.
DOI Scopus3 WoS3 Europe PMC1 |
| 2021 |
Qu, Y., Zhang, B., Wang, Y., Yin, S., Pederick, J. L., Bruning, J. B., . . . Bi, J. (2021). Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope. Vaccine, 39(34), 4830-4841.
DOI Scopus6 WoS4 Europe PMC2 |
| 2021 |
Downes, C. E. J., McClure, B. J., Bruning, J. B., Page, E., Breen, J., Rehn, J., . . . White, D. L. (2021). Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia. NPJ Precision Oncology, 5(1), 1-13.
DOI Scopus11 WoS8 Europe PMC7 |
| 2021 |
Frkic, R. L., Richter, K., & Bruning, J. B. (2021). The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes.. The Journal of biological chemistry, 297(3), 101030.
DOI Scopus33 WoS21 Europe PMC17 |
| 2021 |
Marshall, A. C., & Bruning, J. B. (2021). Engineering potassium activation into biosynthetic thiolase. The Biochemical journal, 478(15), 3047-3062.
DOI Scopus1 |
| 2021 |
Chao, R., Lau, I., Coleman, T., Churchman, L. R., Child, S. A., Lee, J. H. Z., . . . Bell, S. G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry: A European Journal, 27(59), 14765-14777.
DOI Scopus6 WoS6 Europe PMC2 |
| 2021 |
Horsfall, A. J., Vandborg, B., Kikhtyak, Z., Scanlon, D. B., Tilley, W. D., Hickey, T. E., . . . Abell, A. D. (2021). A cell permeable bimane-constrained PCNA-interacting peptide. RSC Chemical Biology, 2(5), 1499-1508.
DOI Scopus5 WoS3 Europe PMC2 |
| 2021 |
Schumann, N. C., Lee, K. J., Thompson, A. P., Salaemae, W., Pederick, J. L., Avery, T., . . . Abell, A. D. (2021). Inhibition of Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS): toward next-generation antituberculosis agents. ACS Chemical Biology, 16(11), 2339-2347.
DOI Scopus5 WoS3 Europe PMC3 |
| 2021 |
Podgorski, M. N., Coleman, T., Giang, P. D., Wang, C. R., Bruning, J. B., Bernhardt, P. V., . . . Bell, S. G. (2021). To be, or not to be, an Inhibitor: a comparison of azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61(1), 236-245.
DOI Scopus5 WoS4 |
| 2021 |
Slynko, I., Nguyen, S., Hamilton, E. M. C., Wisse, L. E., de Esch, I. J. P., de Graaf, C., . . . van der Knaap, M. S. (2021). Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.. Molecular genetics & genomic medicine, 9(3), 1-15.
DOI Scopus16 WoS14 Europe PMC10 |
| 2021 |
Nguyen, S., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2021). Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase.. The FEBS journal, 288(7), 2398-2417.
DOI Scopus6 WoS6 Europe PMC4 |
| 2021 |
Nguyen, S., Truong, J. Q., & Bruning, J. B. (2021). Targeting Unconventional Pathways in Pursuit of Novel Antifungals.. Front Mol Biosci, 7, 1-16.
DOI Scopus11 WoS6 Europe PMC6 |
| 2021 |
Truong, J. Q., Nguyen, S., Bruning, J. B., & Shearwin, K. E. (2021). Derivatization of protein crystals with I3C using random microseed matrix screening. Journal of Visualized Experiments, 2021(167), 1-19.
DOI WoS1 Europe PMC1 |
| 2021 |
Coleman, T., Kirk, A. M., Chao, R. R., Podgorski, M. N., Harbort, J. S., Churchman, L. R., . . . Bell, S. G. (2021). Understanding the Mechanistic Requirements for Efficient and Stereoselective Alkene Epoxidation by a Cytochrome P450 Enzyme. ACS Catalysis, 11(4), 1995-2010.
DOI Scopus29 WoS21 |
| 2020 |
Jia, Y., Shen, G., Nguyen, S., Zhang, Y., Huang, K. -S., Ho, H. -Y., . . . Wang, W. -L. (2020). Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity.
DOI Europe PMC2 |
| 2020 |
Horsfall, A. J., Abell, A. D., & Bruning, J. (2020). Targeting PCNA with peptide mimetics for therapeutic purposes. ChemBioChem, 21(4), 442-450.
DOI Scopus22 WoS15 Europe PMC12 |
| 2020 |
Podgorski, M. N., Coleman, T., Chao, R. R., De Voss, J. J., Bruning, J. B., & Bell, S. G. (2020). Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. Journal of Inorganic Biochemistry, 203, 110913-1-110913-13.
DOI Scopus21 WoS19 Europe PMC8 |
| 2020 |
Podgorski, M. N., Harbort, J. S., Coleman, T., Stok, J. E., Yorke, J. A., Wong, L. -L., . . . Bell, S. G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59(9), 1038-1050.
DOI Scopus19 WoS15 Europe PMC5 |
| 2020 |
Coleman, T., Stok, J. E., Podgorski, M. N., Bruning, J. B., De Voss, J. J., & Bell, S. G. (2020). Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry, 25(4), 583-596.
DOI Scopus24 WoS24 Europe PMC10 |
| 2020 |
Pederick, J. L., Thompson, A. P., Bell, S. G., & Bruning, J. B. (2020). D-alanine-D-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.. The Journal of biological chemistry, 295(23), 7894-7904.
DOI Scopus18 WoS15 Europe PMC8 |
| 2020 |
Child, S. A., Ghith, A., Bruning, J. B., & Bell, S. G. (2020). A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis. Journal of Inorganic Biochemistry, 209, 1-12.
DOI Scopus11 WoS8 Europe PMC1 |
| 2020 |
Xie, J., De Poi, S., Humphrey, S., Hein, L., Bruning, J., Pan, W., . . . Proud, C. (2020). TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming.
DOI |
| 2019 |
Truong, J. Q., Panjikar, S., Shearwin-Whyatt, L., Bruning, J. B., & Shearwin, K. E. (2019). Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68. Acta crystallographica Section D. Structural biology, 75(7), 670-681.
DOI Scopus3 WoS3 Europe PMC2 |
| 2019 |
Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., . . . Abell, A. D. (2019). Sulfonamide-based inhibitors of biotin protein ligase as new antibiotic leads. ACS Chemical Biology, 14(9), 1990-1997.
DOI Scopus5 WoS4 Europe PMC1 |
| 2019 |
Jia, Y., Burbidge, C. A., Sweetman, C., Schutz, E., Soole, K., Jenkins, C., . . . Ford, C. M. (2019). An aldo-keto reductase with 2-keto- L-gulonate reductase activity functions in L-tartaric acid biosynthesis from vitamin C in Vitis vinifera. The Journal of biological chemistry, 294(44), 15932-15946.
DOI Scopus15 WoS12 Europe PMC7 |
| 2019 |
Schumann, N. C., Bruning, J., Marshall, A. C., & Abell, A. D. (2019). The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin. Bioorganic and Medicinal Chemistry Letters, 29(3), 396-399.
DOI Scopus2 WoS2 Europe PMC1 |
| 2019 |
Marshall, A. C., Kidd, S. E., Lamont-Friedrich, S. J., Arentz, G., Hoffmann, P., Coad, B. R., & Bruning, J. B. (2019). Structure, mechanism, and inhibition of aspergillus fumigatus thioredoxin reductase. Antimicrobial Agents and Chemotherapy, 63(3), 1-15.
DOI Scopus27 WoS25 Europe PMC12 |
| 2019 |
Elzahhar, P. A., Alaaeddine, R., Ibrahim, T. M., Nassra, R., Ismail, A., Chua, B. S. K., . . . Belal, A. S. F. (2019). Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones. European Journal of Medicinal Chemistry, 167, 562-582.
DOI Scopus34 WoS28 Europe PMC9 |
| 2019 |
Child, S. A., Flint, K. L., Bruning, J. B., & Bell, S. G. (2019). The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum. Biochimica et Biophysica Acta - General Subjects, 1863(5), 925-934.
DOI Scopus4 WoS4 |
| 2019 |
Chang, M. R., Ciesla, A., Strutzenberg, T. S., Novick, S. J., He, Y., Garcia-Ordonez, R. D., . . . Griffin, P. R. (2019). Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways. ACS Chemical Biology, 14(5), 1051-1062.
DOI Scopus8 WoS8 Europe PMC3 |
| 2018 |
Marshall, A., Keiller, B., Pederick, J., Abell, A., & Bruning, J. (2018). Crystal structure of bovine alpha-chymotrypsin in space group P65. Crystals, 8(12), 460.
DOI Scopus3 WoS1 |
| 2018 |
Frkic, R. L., Chua, B. S., Shin, Y., Pascal, B. D., Novick, S. J., Kamenecka, T. M., . . . Bruning, J. B. (2018). Structural and dynamic elucidation of a non-acid PPARγ partial agonist: SR1988. Nuclear Receptor Research, 5, 101350-1-101350-12.
DOI Europe PMC3 |
| 2018 |
Child, S., Naumann, E., Bruning, J., & Bell, S. (2018). Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum. The Biochemical Journal, 475(4), 705-722.
DOI Scopus13 WoS11 Europe PMC2 |
| 2018 |
Marshall, A., Bond, C., & Bruning, J. (2018). Structure of Aspergillus fumigatus Cytosolic thiolase: trapped tetrahedral reaction intermediates and activation by monovalent cations. ACS Catalysis, 8(3), 1973-1989.
DOI Scopus4 WoS3 |
| 2018 |
Coleman, T., Wong, S., Podgorski, M., Bruning, J., De Voss, J., & Bell, S. (2018). Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyses heteroatom dealkylations, sulfoxidation and amide and cyclic hemiacetal formation. ACS Catalysis, 8(7), 5915-5927.
DOI Scopus25 WoS22 |
| 2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. (2018). Rational design of a 310-helical PIP-box mimetic targeting PCNA - the human sliding clamp. Chemistry - A European Journal, 24(44), 11325-11331.
DOI Scopus14 WoS10 Europe PMC7 |
| 2018 |
Thompson, A., Wegener, K., Booker, G., Polyak, S., & Bruning, J. (2018). Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallographica Section D: Structural Biology, 74(10), 965-972.
DOI Scopus4 WoS4 Europe PMC1 |
| 2018 |
Frkic, R. L., Marshall, A. C., Blayo, A. -L., Pukala, T. L., Kamenecka, T. M., Griffin, P. R., & Bruning, J. B. (2018). PPARγ in complex with an antagonist and inverse agonist: a tumble and trap mechanism of the activation helix. iScience, 5, 69-79.
DOI Scopus38 WoS31 Europe PMC18 |
| 2018 |
Zheng, J., Corzo, C., Chang, M., Shang, J., Lam, V., Brust, R., . . . Griffin, P. (2018). Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism. Structure, 26(11), 1431-1439.
DOI Scopus21 WoS18 Europe PMC16 |
| 2018 |
Thompson, A. P., Salaemae, W., Pederick, J. L., Abell, A. D., Booker, G. W., Bruning, J. B., . . . Polyak, S. W. (2018). Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. ACS Catalysis, 8(11), 10774-10783.
DOI Scopus7 WoS5 |
| 2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. B. (2018). Front Cover: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018). Chemistry – A European Journal, 24(44), 11234.
DOI |
| 2017 |
Stevens, T., Song, S., Bruning, J., Choo, A., & Baxter, S. (2017). Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor. Insect Biochemistry and Molecular Biology, 80, 61-70.
DOI Scopus42 WoS39 Europe PMC19 |
| 2017 |
Marshall, A., Kroker, A., Murray, L., Gronthos, K., Rajapaksha, H., Wegener, K., & Bruning, J. (2017). Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21. FEBS Journal, 284(6), 985-1002.
DOI Scopus11 WoS9 Europe PMC7 |
| 2017 |
Sternicki, L., Wegener, K., Bruning, J., Booker, G., & Polyak, S. (2017). Mechanisms governing precise protein biotinylation. Trends in Biochemical Sciences, 42(5), 383-394.
DOI Scopus20 WoS17 Europe PMC8 |
| 2017 |
Rajapaksha, H., Bhatia, H., Wegener, K., Petrovsky, N., & Bruning, J. (2017). X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs. Biochimica et Biophysica Acta - General Subjects, 1861(8), 1981-1991.
DOI Scopus15 WoS16 Europe PMC4 |
| 2017 |
Frkic, R., He, Y., Rodriguez, B., Chang, M., Kuruvilla, D., Ciesla, A., . . . Bruning, J. (2017). Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. Journal of Medicinal Chemistry, 60(11), 4584-4593.
DOI Scopus22 WoS18 Europe PMC8 |
| 2017 |
Zheng, J., Chang, M., Stites, R., Wang, Y., Bruning, J., Pascal, B., . . . Griffin, P. (2017). HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nature Communications, 8(1), 923-1-923-13.
DOI Scopus30 WoS26 Europe PMC19 |
| 2016 |
Van Marrewijk, L., Polyak, S., Hijnen, M., Kuruvilla, D., Chang, M., Shin, Y., . . . Bruning, J. (2016). SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism. ACS Chemical Biology, 11(1), 273-283.
DOI Scopus31 WoS26 Europe PMC14 |
| 2016 |
Zhang, X., Bruning, J., George, J., & Abell, A. (2016). A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Organic and Biomolecular Chemistry, 14(29), 6970-6978.
DOI Scopus11 WoS10 |
| 2016 |
Stechschulte, L., Czernik, P., Rotter, Z., Tausif, F., Corzo, C., Marciano, D., . . . Lecka-Czernik, B. (2016). PPARG Post-translational modifications regulate bone formation and bone resorption. EBioMedicine, 10, 174-184.
DOI Scopus58 WoS52 Europe PMC42 |
| 2015 |
Jia, Y., Wong, D., Sweetman, C., Bruning, J., & Ford, C. (2015). New insights into the evolutionary history of plant sorbitol dehydrogenase. BMC Plant Biology, 15(1), 101-1-101-23.
DOI Scopus24 WoS21 Europe PMC14 |
| 2015 |
Kroker, A., & Bruning, J. (2015). p21 exploits residue Tyr151 as a tether for high-affinity PCNA binding. Biochemistry, 54(22), 3483-3493.
DOI Scopus24 WoS23 Europe PMC15 |
| 2015 |
Coleman, T., Chao, R., Bruning, J., De Voss, J., & Bell, S. (2015). CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives. RSC Advances, 5(64), 52007-52018.
DOI Scopus27 WoS25 |
| 2015 |
Marciano, D., Kuruvilla, D., Boregowda, S., Asteian, A., Hughes, T., Garcia-Ordonez, R., . . . Griffin, P. (2015). Pharmacological repression of PPARγ promotes osteogenesis. Nature Communications, 6(1), 7443-1-7443-7.
DOI Scopus93 WoS84 Europe PMC60 |
| 2015 |
Kojetin, D., Matta-Camacho, E., Hughes, T., Srinivasan, S., Nwachukwu, J., Cavett, V., . . . Nettles, K. (2015). Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nature Communications, 6(1), 8013-1-8013-14.
DOI Scopus96 WoS87 Europe PMC67 |
| 2015 |
Kroker, A., & Bruning, J. (2015). Review of the structural and dynamic mechanisms of PPAR γ partial agonism. PPAR Research, 2015, 816856-1-816856-15.
DOI Scopus140 WoS104 Europe PMC77 |
| 2014 |
Chua, K., Pietsch, M., Zhang, X., Hautmann, S., Chan, H., Bruning, J., . . . Abell, A. (2014). Macrocyclic protease inhibitors with reduced peptide character. Angewandte Chemie International Edition, 53(30), 7828-7831.
DOI Scopus23 WoS20 Europe PMC8 |
| 2014 |
Sullivan, A., Raimondo, A., Schwab, T., Bruning, J., Froguel, P., Farooqi, I., . . . Whitelaw, M. (2014). Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. Biochemical Journal, 461(3), 403-412.
DOI Scopus9 WoS8 Europe PMC8 |
| 2014 |
Bersten, D., Bruning, J., Peet, D., & Whitelaw, M. (2014). Human variants in the Neuronal Basic Helix-Loop-Helix/ Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One, 9(1), e85768-1-e85768-11.
DOI Scopus19 WoS20 Europe PMC19 |
| 2014 |
Reddy, M., Breda, A., Bruning, J., Sherekar, M., Valluru, S., Thurman, C., . . . Sacchettini, J. (2014). Structure, activity, and inhibition of the carboxyltransferase β-Subunit of acetyl coenzyme a carboxylase (AccD6) from mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 58(10), 6122-6132.
DOI Scopus17 WoS16 Europe PMC7 |
| 2013 |
Mosser, R., Reddy, M., Bruning, J., Sacchettini, J., & Reinhart, G. (2013). Redefining the role of the quaternary shift in bacillus stearothermophilus phosphofructokinase. Biochemistry, 52(32), 5421-5429.
DOI Scopus4 WoS4 Europe PMC3 |
| 2013 |
Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D., . . . Froguel, P. (2013). Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. Journal of Clinical Investigation, 123(7), 3037-3041.
DOI Scopus93 WoS78 Europe PMC64 |
| 2013 |
Ramachandrappa, S., Raimondo, A., Cali, A., Keogh, J., Henning, E., Saeed, S., . . . Farooqi, I. (2013). Rare variants in single-minded 1 (SIM1) are associated with severe obesity. Journal of Clinical Investigation, 123(7), 3042-3050.
DOI Scopus118 WoS98 Europe PMC83 |
| 2012 |
Mosser, R., Reddy, M., Bruning, J., Sacchettini, J., & Reinhart, G. (2012). Structure of the apo form of Bacillus Stearothermophilus Phosphofructokinase. Biochemistry, 51(3), 769-775.
DOI Scopus8 WoS8 Europe PMC6 |
| 2011 |
Bruning, J., Murillo, A., Chacon, O., Barletta, R., & Sacchettini, J. (2011). Structure of the Mycobacterium tuberculosis D-alanine:D-alanine Ligase, a target of the antituberculosis drug D-Cycloserine. Antimicrobial Agents and Chemotherapy, 55(1), 291-301.
DOI Scopus113 WoS103 Europe PMC60 |
| 2011 |
Zhang, J., Chalmers, M., Stayrook, K., Burris, L., Wang, Y., Busby, S., . . . Griffin, P. (2011). DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nature Structural and Molecular Biology, 18(5), 556-563.
DOI Scopus166 WoS146 Europe PMC114 |
| 2011 |
Chim, N., Habel, J., Johnston, J., Krieger, I., Miallau, L., Sankaranarayanan, R., . . . Goulding, C. (2011). The TB structural genomics consortium: a decade of progress. Tuberculosis, 91(2), 155-172.
DOI Scopus35 WoS32 Europe PMC24 |
| 2011 |
Choi, J., Banks, A., Kamenecka, T., Busby, S., Chalmers, M., Kumar, N., . . . Griffin, P. (2011). Anti-diabetic actions of a non-agonist PPARgamma ligand that blocks Cdk5-mediated phosphorylation. Nature, 477(7365), 477-481.
DOI Scopus439 WoS381 Europe PMC316 |
| 2010 |
Bruning, J., Parent, A., Gil, G., Zhao, M., Nowak, J., Pace, M., . . . Nettles, K. (2010). Coupling of receptor conformation and ligand orientation determine graded activity. Nature Chemical Biology, 6(11), 837-843.
DOI Scopus113 WoS109 Europe PMC76 |
| 2009 |
Reddy, M., Palaninathan, S., Bruning, J., Thurman, C., Smith, D., & Sacchettini, J. (2009). Structural insights into the mechanism of the allosteric transitions of Mycobacterium Tuberculosis cAMP receptor protein. Journal of Biological Chemistry, 284(52), 36581-36591.
DOI Scopus34 WoS30 Europe PMC22 |
| 2008 |
Nettles, K., Bruning, J., Gil, G., Nowak, J., Sharma, S., Hahm, J., . . . Greene, G. (2008). NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nature Chemical Biology, 4(4), 241-247.
DOI Scopus131 WoS127 Europe PMC86 |
| 2008 |
Dai, S., Chalmers, M., Bruning, J., Bramlett, K., Osborne, H., Montrose-Rafizadeh, C., . . . Griffin, P. (2008). Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proceedings of the National Academy of Sciences of the United States of America, 105(20), 7171-7176.
DOI Scopus79 WoS67 Europe PMC54 |
| 2007 |
Nettles, K., Bruning, J., Gil, G., O'Neill, E., Nowak, J., Hughs, A., . . . Greene, G. (2007). Structural plasticity in the oestrogen receptor ligand-binding domain. EMBO Reports, 8(6), 563-568.
DOI Scopus115 WoS109 Europe PMC80 |
| 2007 |
Zhou, H., Nettles, K., Bruning, J., Kim, Y., Joachimiak, A., Sharma, S., . . . Katzenellenbogen, J. (2007). Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands. Chemistry & Biology, 14(6), 659-669.
DOI Scopus62 WoS62 Europe PMC38 |
| 2007 |
Bruning, J., Chalmers, M., Prasad, S., Busby, S., Kamenecka, T., He, Y., . . . Griffin, P. (2007). Partial agonists activate PPARγ using a helix 12 independent mechanism. Structure, 15(10), 1258-1271.
DOI Scopus302 WoS278 Europe PMC189 |
| 2004 |
Bruning, J. B., & Shamoo, Y. (2004). Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1. Structure, 12(12), 2209-2219.
DOI Scopus172 WoS168 Europe PMC137 |
