Joel Castro Kraftchenko

Joel Castro Kraftchenko
Adelaide Medical School
Faculty of Health and Medical Sciences

2015: Joel Castro (Kraftchenko) Research Officer
Visceral Pain Laboratory (SAHMRI)
Flinders University.

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Joel Castro Kraftchenko

2015: Joel Castro (Kraftchenko) Research Officer
Visceral Pain Laboratory (SAHMRI)
Flinders University.


Date Position Institution name
2015 NHMRC Postdoc Researcher (Academic B) University of Adelaide

Language Competencies

Language Competency
English Can peer review
Spanish; Castilian Can peer review


Date Institution name Country Title
2005 - 2008 Flinders University Australia PhD


Year Citation
2017 Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J. ... Brierley, S. (2017). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66, 6, 1083-1094. 10.1136/gutjnl-2015-310971
2017 Bellono, N., Bayrer, J., Leitch, D., Castro, J., Zhang, C., O'Donnell, T. ... Julius, D. (2017). Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell, 170, 1, 185-198.e16. 10.1016/j.cell.2017.05.034
2017 Wan, J., Mobli, M., Brust, A., Muttenthaler, M., Andersson, �. �., Ragnarsson, L. ... Alewood, P. (2017). Synthesis of multivalent [Lys⁸]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70, 2, 162-171. 10.1071/CH16407
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A. ... Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7, 42810-1-42810-19. 10.1038/srep42810
2016 Deiteren, A., Castro, J., O'Donnell, T., Craik, D., Adams, D. & Brierley, S. (2016). Modulation of colonic sensory signaling by novel alpha-conotoxin Vc1.1 analogues in mice. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 103-103.
2016 Carstens, B., Berecki, G., Daniel, J., Lee, H., Jackson, K., Tae, H. ... Clark, R. (2016). Structure-activity studies of cysteine-Rich α-conotoxins that inhibit high-voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif. Angewandte Chemie - International Edition, 55, 15, 4692-4696. 10.1002/anie.201600297
2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X. ... Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534, 7608, 494-499. 10.1038/nature17976
2016 Brust, A., Croker, D., Colless, B., Ragnarsson, L., Andersson, �. �., Jain, K. ... Lewis, R. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin A mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59, 6, 2381-2395. 10.1021/acs.jmedchem.5b00911
2016 Garcia-Caraballo, S., Harrington, A., Castro, J., Hannig, G., Kurtz, C., Silos-Santiago, A. ... Brierley, S. (2016). Guanylate cyclase-C expression is down-regulated in colonic biopsies from female irritable bowel syndrome patients with constipation. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 102-102.
2015 Fournel, A., Drougard, A., Duparc, T., Marlin, A., Brierley, S., Castro, J. ... Knauf, C. (2015). Apelin targets gut contraction to control glucose metabolism via the brain.. Gut, 66, 2, 258-269. 10.1136/gutjnl-2015-310230
2014 de Araujo, A., Mobli, M., Castro, J., Harrington, A., Vetter, I., Dekan, Z. ... Alewood, P. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Coomunications, 5, 3165-1-3165-12. 10.1038/ncomms4165
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G. ... Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online, 7, 1-2. 10.1136/gutjnl-2013-306240
2013 Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C. ... Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145, 6, 1334-1346. 10.1053/j.gastro.2013.08.017
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D. ... Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62, 10, 1456-1465. 10.1136/gutjnl-2011-301856
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J. & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520, 10, 2241-2255. 10.1002/cne.23042
2011 Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G. & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589, 14, 3575-3593. 10.1113/jphysiol.2011.206789
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N. ... Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152, 7, 1459-1468. 10.1016/j.pain.2011.01.027
2011 Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G. & Rychkov, G. (2011). The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²⁺ entry in liver cells. Biochimica et Biophysica Acta-Biomembranes, 1808, 3, 745-751. 10.1016/j.bbamem.2010.12.013
2010 To, M., Aromataris, E., Castro, J., Roberts, M., Barritt, G. & Rychkov, G. (2010). Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells. Archives of Biochemistry and Biophysics, 495, 2, 152-158. 10.1016/
2009 Castro, J., Aromataris, E., Rychkov, G. & Barritt, G. (2009). A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochemical Journal, 418, Part 3, 553-566. 10.1042/BJ20081052
2009 Barritt, G., Litjens, T., Castro, J., Aromataris, E. & Rychkov, G. (2009). Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. Clinical and Experimental Pharmacology and Physiology, 36, 1, 77-83. 10.1111/j.1440-1681.2008.05095.x
2008 Aromataris, E., Castro, J., Rychkov, G. & Barritt, G. (2008). Store-operated Ca2+ channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1783, 5, 874-885. 10.1016/j.bbamcr.2008.02.011
2007 Litjens, T., Nguyen, T., Castro Kraftchenko, J., Aromataris, E., Jones, L., Barritt, G. & Rychkov, G. (2007). Phospholipase C-γ1 is required for the activation of store-operated Ca²⁺ channels in liver cells. Biochemical Journal, 405, 2, 269-276. 10.1042/BJ20061762
2006 Castro, J., Ruminot, I., Porras, O., Flores, C., Hermosilla, T., Verdugo, E. ... Barros, L. (2006). ATP steal between cation pumps: A mechanism linking Na+ influx to the onset of necrotic Ca2+ overload. Cell Death and Differentiation, 13, 10, 1675-1685. 10.1038/sj.cdd.4401852
2004 Castro, J., Bittner, C., Humeres, A., Montecinos, V., Vera, J. & Barros, L. (2004). A cytosolic source of calcium unveiled by hydrogen peroxide with relevance for epithelial cell death. Cell Death and Differentiation, 11, 4, 468-478. 10.1038/sj.cdd.4401372
2003 Barros, L., Kanaseki, T., Sabirov, R., Morishima, S., Castro, J., Bittner, C. ... Okada, Y. (2003). Apoptotic and necrotic blebs in epethelial cells display similar neck diameters but different kinase dependency. Cell Death and Differentiation, 10, 6, 687-697. 10.1038/sj.cdd.4401236
2002 Barros, L., Castro, J. & Bittner, C. (2002). Ion movements in cell death: From protection to execution. Biological Research, 35, 2, 209-214.
2001 Barros, L., Stutzin, A., Calixto, A., Catalán, M., Castro, J., Hetz, C. & Hermosilla, T. (2001). Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology, 33, 1, 114-122. 10.1053/jhep.2001.20530
2001 Barros, F., Barnes, K., Ingram, J., Castro, J., Porras, O. & Baldwin, S. (2001). Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells. Pflugers Archiv European Journal of Physiology, 442, 4, 614-621. 10.1007/s004240100577
2001 Barros, L., Hermosilla, T. & Castro, J. (2001). Necrotic volume increase and the early physiology of necrosis. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, 130, 3, 401-409. 10.1016/S1095-6433(01)00438-X
2000 Quintanilla, R., Porras, O., Castro, J. & Barros, L. (2000). Cytosolic [Ca2+] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells. Cell Calcium, 28, 2, 97-106. 10.1054/ceca.2000.0135

Book Chapters

Year Citation
2012 Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A. & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (pp. 379-390). USA: Springer. 10.1007/978-1-62703-095-3_23

Conference Items

Year Citation
2016 Carstens, B., Berecki, G., Daniel, J., Lee, H., Jackson, K., Tae, H. -. S. ... Clark, R. (2016). MINIATURISED ALPHA-CONOTOXINS FOR THE TREATMENT OF PAIN.
2014 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N. ... Brierley, S. M. (2014). Distinct alterations in the guanylate cyclase-C/cGMP pathway are evident across different subtypes of irritable bowel syndrome patients. 1st Federation Neurogastroenterology and Motility Scientific Meeting (FNM). Guangzhou, China. 10.1111/nmo.12412
2014 Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A. & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. 1st Federation Neurogastroenterology and Motility Scientific Meeting (FNM). Guangzhou, China. 10.1111/nmo.12412
2013 Castro, J., Harrington, A. M., Mann, E., Cohen, M. B., Kurtz, C., Silos-Santiago, A. & Brierley, S. M. (2013). Mechanisms of linaclotide-induced inhibition of colonic nociception. 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting. Huntington Beach, CA. 10.1111/nmo.12186
2013 Hannig, G., Castro, J., Harrington, A., Ge, P., Jin, H., Kessler, M. M. ... Silos-Santiago, I. (2013). Activation of the guanylate cyclase-C/cGMP pathway decreases gastrointestinal pain. Gastro 2013 APDW/WCOG Shanghai, Asian Pacific Digestive Week 2013, World Congress of Gastroenterology. Shanghai, China. 10.1111/jgh.12365_7
2013 Harrington, A. M., Castro, J. & Brierley, S. M. (2013). Peripheral modulation of TRPA1 alters dorsal horn neuron activation to colorectal distension.
2013 Brierley, S., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A. ... Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Annual General Meeting of the British-Society-of-Gastroenterology. Glasgow, SCOTLAND. 10.1136/gutjnl-2013-304907.225
2013 Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N. ... Brierley, S. M. (2013). The guanylatecyclase-c/CGMP pathway is altered in patients with irritable bowel syndrome with constipation. 10.1111/nmo.12187
2013 Castro, J., Harrington, A. M. & Brierley, S. M. (2013). TRPV3 contributes to chronic visceral mechanical hypersensitivity. 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting. Huntington Beach, California. 10.1111/nmo.12186
2011 Castro, J., Hughes, P., Martin, C., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. & Brierley, S. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice.
2010 Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P. & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Joint International Neurogastroenterology and Motility Meeting, NGM. Boston, MA, USA. 10.1111/j.1365-2982.2010.01549.x
2008 Aromataris, E. C., Castro, J., Rychkov, G. Y. & Barritt, G. J. (2008). Bile acids modulate store-operated CA2+ channels and stromal interaction molecule1 (STIM1) distribution in liver cells. 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy. 10.1016/S0168-8278(08)60451-1
2008 Castro, J., Aromataris, E., Barritt, G. & Rychkov, G. (2008). Differential effects of cholestatic and choleretic bile acids on store-operated Ca2+ channels in liver [Abstract]. Annual Meeting of the Society of General Physiologists. Massachusetts, USA.

PhD Co-supervisor of Andelain Erickson (student number 1602281)

Org Unit
Medical Specialties