Joel Castro Kraftchenko

School of Biomedicine

Faculty of Health and Medical Sciences

2015: Joel Castro (Kraftchenko) Research Officer
Visceral Pain Laboratory (SAHMRI)
Flinders University.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Contact

Dr. Joel Castro Kraftchenko (known as Joel Castro on its publication records) is a principal investigator and Head of the Endometriosis Research Unit at the Visceral Pain Research Group, located at the South Australian Health and Medical Research Institute (SAHMRI). He is an expert in the field of visceral nociception and pain and his research focuses on understanding the causes, and developing treatments, for chronic visceral pain associated with endometriosis. Dr. Castro’s research has contributed 62 peer-reviewed manuscripts in top ranked journals including Nature (x2), Cell, Nature Communication, Gastroenterology, Gut, PNAS, Pain, and JCI insight. Together these outputs have been cited over 4838 times (Google Scholar October 2024) with and h-index of 36.

Dr Castro’s research focuses on studying the sensory afferents innervating visceral organs, to understand how pain is detected from these sites. He investigates the ion channels/receptors expressed within these afferents (which govern their function); how these afferents are altered in animal models of endometriosis, and what changes in ion channel/receptor expression occur, to trigger these alterations and cause chronic visceral pain.

Throughout his career Dr. Castro has contributed to the establishment and characterisation of two clinically relevant animal models of endometriosis. He has developed several techniques crucial to identify functional, structural, and molecular characteristics of sensory fibres innervating visceral organs in health and disease states. He has used this knowledge to propose novel non-invasive, non-addictive approaches to reduce CPP in these disorders.

Appointments

Date Position Institution name

2015 - ongoing NHMRC Postdoc Researcher (Academic B) University of Adelaide
Language Competencies

Language Competency

English Can peer review

Spanish; Castilian Can peer review
Education

Date Institution name Country Title

2005 - 2008 Flinders University Australia PhD
Research Interests

Neuroscience, Behaviour and Brain Health Innovative Therapeutics

Date	Position	Institution name
2015 - ongoing	NHMRC Postdoc Researcher (Academic B)	University of Adelaide

Language	Competency
English	Can peer review
Spanish; Castilian	Can peer review

Date	Institution name	Country	Title
2005 - 2008	Flinders University	Australia	PhD

Journals

Year	Citation
2024	Castro, J., Maddern, J., Chow, C. Y., Tran, P., Vetter, I., King, G. F., & Brierley, S. M. (2024). The voltage-gated sodium channel NaV1.7 underlies endometriosis-associated chronic pelvic pain. Journal of Neurochemistry, 168(11), 3760-3776. DOI Scopus4 WoS1 Europe PMC1
2024	Castro, J., Maddern, J., Erickson, A., Harrington, A. M., & Brierley, S. M. (2024). Peripheral and central neuroplasticity in a mouse model of endometriosis. Journal of Neurochemistry, 168(11), 3777-3800. DOI Scopus7 Europe PMC2
2023	Bayrer, J. R., Castro, J., Venkataraman, A., Touhara, K. K., Rossen, N. D., Morrie, R. D., . . . Julius, D. (2023). Gut enterochromaffin cells drive visceral pain and anxiety. Nature, 616(7955), 137-142. DOI Scopus60 WoS7 Europe PMC35
2023	Grundy, L., Tay, C., Christie, S., Harrington, A. M., Castro, J., Cardoso, F. C., . . . Brierley, S. M. (2023). The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164(5), 1012-1026. DOI Scopus5 WoS2 Europe PMC4
2022	Maddern, J., Grundy, L., Harrington, A., Schober, G., Castro, J., & Brierley, S. M. (2022). A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours. Pain, 163(8), 1622-1635. DOI Scopus5 WoS4 Europe PMC2
2022	Castro, J., Harrington, A. M., Chegini, F., Matusica, D., Spencer, N. J., Brierley, S. M., . . . Barry, C. M. (2022). Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia.. Front Cell Infect Microbiol, 11, 1-11. DOI Scopus7 WoS3 Europe PMC6
2022	Caldwell, A., Grundy, L., Harrington, A. M., Garcia-Caraballo, S., Castro, J., Bunnett, N. W., & Brierley, S. M. (2022). TGR5 agonists induce peripheral and central hypersensitivity to bladder distension. Scientific Reports, 12(1), 9920-1-9920-19. DOI Scopus4 WoS1 Europe PMC1
2022	Kyloh, M. A., Hibberd, T. J., Castro, J., Harrington, A. M., Travis, L., Dodds, K. N., . . . Spencer, N. J. (2022). Disengaging spinal afferent nerve communication with the brain in live mice. Communications Biology, 5(1), 915-1-915-15. DOI Scopus9 WoS2 Europe PMC1
2022	Castro, J., Garcia-Caraballo, S., Maddern, J., Schober, G., Lumsden, A., Harrington, A., . . . Brierley, S. M. (2022). Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents. Pain, 163(1), e72-e86. DOI Scopus19 WoS12 Europe PMC10
2021	Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N. J., Dong, X., . . . Brierley, S. M. (2021). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. The Journal of Neuroscience, 14(17), 3900-3916. DOI Scopus12 WoS7 Europe PMC4
2021	Castro, J., Maddern, J., Grundy, L., Manavis, J., Harrington, A. M., Schober, G., & Brierley, S. M. (2021). A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities. The FASEB Journal, 35(4), 1-20. DOI Scopus13 WoS8 Europe PMC5
2021	Brierley, S. M., Grundy, L., Castro, J., Harrington, A. M., Hannig, G., & Camilleri, M. (2021). Guanylate cyclase-C agonists as peripherally acting treatments of chronic visceral pain. Trends in Pharmacological Sciences, 43(2), 110-122. DOI Scopus13 WoS2 Europe PMC8
2021	Brizuela, M., Castro, J., Harrington, A. M., & Brierley, S. M. (2021). Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome. American Journal of Physiology: Gastrointestinal and Liver Physiology, 320(6), G1131-G1141. DOI Scopus8 WoS6 Europe PMC4
2021	Jiang, Y., Castro, J., Blomster, L. V., Agwa, A. J., Maddern, J., Schober, G., . . . King, G. F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Naν1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology and Translational Science, 4(4), 1362-1378. DOI Scopus12 WoS7 Europe PMC9
2021	Muratspahić, E., Tomašević, N., Koehbach, J., Duerrauer, L., Hadžić, S., Castro, J., . . . Gruber, C. W. (2021). Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. Journal of Medicinal Chemistry, 64(13), 9042-9055. DOI Scopus21 WoS12 Europe PMC14
2021	Castro, J., Maddern, J., Erickson, A., Caldwell, A., Grundy, L., Harrington, A. M., & Brierley, S. M. (2021). Pharmacological modulation of voltage-gated sodium (Na(V)) channels alters nociception arising from the female reproductive tract. Pain, 162(1), 227-242. DOI Scopus9 WoS7 Europe PMC3
2020	Maddern, J., Grundy, L., Castro, J., & Brierley, S. M. (2020). Pain in endometriosis. Frontiers in Cellular Neuroscience, 14, 590823-1-590823-16. DOI Scopus130 WoS26 Europe PMC73
2020	Grundy, L., Caldwell, A., Garcia Caraballo, S., Erickson, A., Schober, G., Castro Kraftchenko, J., . . . Brierley, S. M. (2020). Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H₁ receptor and TRPV1. American journal of physiology. Renal physiology, 318(2), F298-F314. DOI Scopus52 WoS34 Europe PMC34
2020	Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. Gastroenterology, 158(6), S-803. DOI
2020	Cardoso, F. C., Castro, J., Grundy, L., Schober, G., Garcia-Caraballo, S., Zhao, T., . . . Lewis, R. J. (2020). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162(2), 569-581. DOI Scopus28 WoS22 Europe PMC21
2019	Ge, P., Ren, J., Harrington, A. M., Grundy, L., Castro, J., Brierley, S. M., & Hannig, G. (2019). Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk.. Pain, 160(11), 2566-2579. DOI Scopus26 WoS15 Europe PMC13
2019	Castro, J., Harrington, A. M., Lieu, T., Garcia Caraballo, S., Maddern, J., Schober, G., . . . Brierley, S. M. (2019). Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity. JCI insight, 4(20), e131712-1-e131712-24. DOI Scopus59 WoS48 Europe PMC31
2019	Grundy, L., Harrington, A. M., Caldwell, A., Castro, J., Staikopoulos, V., Zagorodnyuk, V. P., . . . Brierley, S. M. (2019). Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice. Pain, 160(4), 793-804. DOI Scopus27 WoS16 Europe PMC14
2019	Israel, M. R., Tanaka, B. S., Castro Kraftchenko, J., Thongyoo, P., Robinson, S. D., Zhao, P., . . . Vetter, I. (2019). Nav1.6 regulates excitability of mechanosensitive sensory neurons. The Journal of Physiology, 597(14), 1-18. DOI Scopus28 WoS23 Europe PMC20
2019	Harrington, A. M., Caraballo, S. G., Maddern, J. E., Grundy, L., Castro, J., & Brierley, S. M. (2019). Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord. American journal of physiology. Gastrointestinal and liver physiology, 317(3), G285-G303. DOI Scopus27 WoS20 Europe PMC14
2018	Grundy, L., Harrington, A. M., Castro, J., Garcia-Caraballo, S., Deiteren, A., Maddern, J., . . . Brierley, S. M. (2018). Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight, 3(19), e121841-1-e121841-20. DOI Scopus57 WoS47 Europe PMC29
2018	Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., . . . Brierley, S. (2018). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology, 175(12), 2384-2398. DOI Scopus37 WoS25 Europe PMC17
2018	Erickson, A., Deiteren, A., Harrington, A., Garcia-Caraballo, S., Castro, J., Caldwell, A., . . . Brierley, S. (2018). Voltage-gated sodium channels: (NaV)igating the field to determine their contribution to visceral nociception. The Journal of Physiology, 596(5), 785-807. DOI Scopus32 WoS30 Europe PMC22
2018	Sadeghi, M., Erickson, A., Castro, J., Deiteren, A., Harrington, A., Grundy, L., . . . Brierley, S. (2018). Contribution of membrane receptor signalling to chronic visceral pain. International Journal of Biochemistry and Cell Biology, 98, 10-23. DOI Scopus29 WoS22 Europe PMC17
2018	Guerrero-Alba, R., Valdez-Morales, E. E., Jiménez-Vargas, N. N., Bron, R., Poole, D., Reed, D., . . . Vanner, S. (2018). Co-expression of μ and ∂ opioid receptors by mouse colonic nociceptors. British Journal of Pharmacology, 175(13), 2622-2634. DOI Scopus24 WoS18 Europe PMC17
2018	Sadeghi, M., Carstens, B., Callaghan, B., Daniel, J., Tae, H., O'Donnell, T., . . . Clark, R. (2018). Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13(6), 1577-1587. DOI Scopus26 WoS26 Europe PMC13
2018	Salvatierra, J., Castro, J., Erickson, A., Li, Q., Braz, J., Gilchrist, J., . . . Bosmans, F. (2018). NaV1.1 inhibition can reduce visceral hypersensitivity. JCI insight, 3(11), e121000-1-e121000-13. DOI Scopus30 WoS29 Europe PMC21
2018	Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T. M., Latorre, R., Jensen, D. D., . . . Bunnett, N. W. (2018). Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome. Proceedings of the National Academy of Sciences of the United States of America, 115(31), E7438-E7447. DOI Scopus132 WoS95 Europe PMC94
2017	Bellono, N., Bayrer, J., Leitch, D., Castro, J., Zhang, C., O'Donnell, T., . . . Julius, D. (2017). Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell, 170(1), 185-198.e16. DOI Scopus607 WoS431 Europe PMC389
2017	Wan, J., Mobli, M., Brust, A., Muttenthaler, M., Andersson, Å., Ragnarsson, L., . . . Alewood, P. (2017). Synthesis of multivalent [Lys⁸]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70(2), 162-171. DOI Scopus10 WoS4
2017	Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A., . . . Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7(1), 42810-1-42810-19. DOI Scopus60 WoS53 Europe PMC39
2017	Fournel, A., Drougard, A., Duparc, T., Marlin, A., Brierley, S., Castro, J., . . . Knauf, C. (2017). Apelin targets gut contraction to control glucose metabolism via the brain.. Gut, 66(2), 258-269. DOI Scopus80 WoS65 Europe PMC51
2017	Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J., . . . Brierley, S. (2017). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66(6), 1083-1094. DOI Scopus77 WoS64 Europe PMC51
2016	Brust, A., Croker, D., Colless, B., Ragnarsson, L., Andersson, Å., Jain, K., . . . Lewis, R. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin A mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59(6), 2381-2395. DOI Scopus29 WoS25 Europe PMC21
2016	Carstens, B., Berecki, G., Daniel, J., Lee, H., Jackson, K., Tae, H., . . . Clark, R. (2016). Structure-activity studies of cysteine-Rich α-conotoxins that inhibit high-voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif. Angewandte Chemie - International Edition, 55(15), 4692-4696. DOI Scopus47 WoS42 Europe PMC24
2016	Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X., . . . Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534(7608), 494-499. DOI Scopus236 WoS202 Europe PMC160
2016	Deiteren, A., Castro, J., O'Donnell, T., Craik, D. J., Adams, D. J., & Brierley, S. M. (2016). Modulation of colonic sensory signaling by novel α-conotoxin Vc1.1 analogues in mice. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 103.
2015	Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). Mo1876 A Visceral Representation of Itch: Identification ‘Itch-Specific’ Pruritogenic Mechanisms Within Colonic Sensory Pathways. Gastroenterology, 148(4), S-733. DOI
2014	de Araujo, A., Mobli, M., Castro, J., Harrington, A., Vetter, I., Dekan, Z., . . . Alewood, P. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Coomunications, 5(1), 3165-1-3165-12. DOI Scopus110 WoS99 Europe PMC48
2013	Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2. DOI Scopus37 WoS34 Europe PMC26
2013	Castro, J., Harrington, A., Hughes, P., Martin, C., Ge, P., Shea, C., . . . Brierley, S. (2013). Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic guanosine 3′,5′-monophosphate. Gastroenterology, 145(6), 1334-1346. DOI Scopus235 WoS192 Europe PMC159
2013	Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465. DOI Scopus172 WoS148 Europe PMC119
2012	Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255. DOI Scopus59 WoS53 Europe PMC33
2011	Brierley, S., Castro Kraftchenko, J., Harrington, A., Hughes, P., Page, A., Rychkov, G., & Blackshaw, L. (2011). TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. Journal of Physiology-London, 589(14), 3575-3593. DOI Scopus113 WoS99 Europe PMC76
2011	Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G., & Rychkov, G. (2011). The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²⁺ entry in liver cells. Biochimica et Biophysica Acta-Biomembranes, 1808(3), 745-751. DOI Scopus5 WoS4 Europe PMC2
2011	Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468. DOI Scopus127 WoS104 Europe PMC90
2010	To, M., Aromataris, E., Castro, J., Roberts, M., Barritt, G., & Rychkov, G. (2010). Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells. Archives of Biochemistry and Biophysics, 495(2), 152-158. DOI Scopus37 WoS34 Europe PMC22
2009	Castro, J., Aromataris, E., Rychkov, G., & Barritt, G. (2009). A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochemical Journal, 418(Part 3), 553-566. DOI Scopus23 WoS22 Europe PMC11
2009	Barritt, G., Litjens, T., Castro, J., Aromataris, E., & Rychkov, G. (2009). Store-operated Ca2+ channels and microdomains of Ca2+ in liver cells. Clinical and Experimental Pharmacology and Physiology, 36(1), 77-83. DOI Scopus25 WoS20 Europe PMC15
2008	Aromataris, E., Castro, J., Rychkov, G., & Barritt, G. (2008). Store-operated Ca2+ channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(5), 874-885. DOI Scopus27 WoS24 Europe PMC12
2007	Litjens, T., Nguyen, T., Castro Kraftchenko, J., Aromataris, E., Jones, L., Barritt, G., & Rychkov, G. (2007). Phospholipase C-γ1 is required for the activation of store-operated Ca²⁺ channels in liver cells. Biochemical Journal, 405(2), 269-276. DOI Scopus32 WoS30 Europe PMC21
2006	Castro, J., Ruminot, I., Porras, O. H., Flores, C. M., Hermosilla, T., Verdugo, E., . . . Barros, L. F. (2006). ATP steal between cation pumps: A mechanism linking Na<sup>+</sup> influx to the onset of necrotic Ca<sup>2+</sup> overload. Cell Death and Differentiation, 13(10), 1675-1685. DOI Scopus20 Europe PMC14
2004	Castro, J., Bittner, C. X., Humeres, A., Montecinos, V. P., Vera, J. C., & Barros, L. F. (2004). A cytosolic source of calcium unveiled by hydrogen peroxide with relevance for epithelial cell death. Cell Death and Differentiation, 11(4), 468-478. DOI Scopus30 Europe PMC23
2003	Barros, L. F., Kanaseki, T., Sabirov, R., Morishima, S., Castro, J., Bittner, C. X., . . . Okada, Y. (2003). Apoptotic and necrotic blebs in epethelial cells display similar neck diameters but different kinase dependency. Cell Death and Differentiation, 10(6), 687-697. DOI Scopus142 Europe PMC102
2002	Barros, L. F., Castro, J., & Bittner, C. X. (2002). Ion movements in cell death: From protection to execution. Biological Research, 35(2), 209-214. DOI Scopus40 Europe PMC20
2001	Barros, L. F., Hermosilla, T., & Castro, J. (2001). Necrotic volume increase and the early physiology of necrosis. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, 130(3), 401-409. DOI Scopus131 Europe PMC82
2001	Barros, L. F., Stutzin, A., Calixto, A., Catalaán, M., Castro, J., Hetz, C., & Hermosilla, T. (2001). Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology, 33(1), 114-122. DOI Scopus63 Europe PMC49
2001	Barros, F. L., Barnes, K., Ingram, J. C., Castro, J., Porras, O. H., & Baldwin, S. A. (2001). Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells. Pflugers Archiv European Journal of Physiology, 442(4), 614-621. DOI Scopus49 Europe PMC34
2000	Quintanilla, R. A., Porras, O. H., Castro, J., & Barros, L. F. (2000). Cytosolic [Ca<sup>2+</sup>] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells. Cell Calcium, 28(2), 97-106. DOI Scopus29 Europe PMC20

Book Chapters

Year	Citation
2023	Maddern, J., Brierley, S. M., & Castro, J. (2023). Pre-clinical Models of Endometriosis: A Focus on Chronic Pain. In Visceral Pain (pp. 209-222). Springer International Publishing. DOI
2018	Harrington, A. M., Castro, J., Erickson, A., Grundy, L., & Brierley, S. M. (2018). Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract in Health and Disease. In H. M. Said (Ed.), Physiology of the Gastrointestinal Tract: Sixth Edition (Vol. 1-2, pp. 387-418). United Kingdom: Academic Press. DOI Scopus21
2012	Hughes, P., Brierley, S., Castro Kraftchenko, J., Harrington, A., & Blackshaw, L. (2012). Experimental colitis models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology: TRP Channels in Drug Discovery, Volume II (Vol. 2, 1 ed., pp. 379-390). USA: Springer. DOI Scopus1

Conference Papers

Year	Citation
2021	Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2021). CANNABINOID RECEPTOR 2 (CB<sub>2</sub>) LOCALIZATION IN COLONIC TISSUE AND PRIMARY SENSORY DORSAL ROOT GANGLIA (DRG) NEURONS ISOLATED FROM RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 160 (pp. S503-S504). ELECTR NETWORK: W B SAUNDERS CO-ELSEVIER INC.
2020	Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. (2020). CANNABINOID RECEPTOR EXPRESSION AND THE EFFECT OF OLORINAB, A PERIPHERALLY ACTING, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), IN RODENTS WITH COLITIS AND CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S269). Austin, TX: W B SAUNDERS CO-ELSEVIER INC.
2020	Castro, J., Maddern, J., Erickson, A., & Brierley, S. (2020). Co-morbidities of IBS: Role of voltage-gated sodium channels in mouse vaginal afferent mechanosensation and pain. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 32 (pp. 1 page). WILEY.
2020	Harrington, A., Garcia-Caraballo, S., Grundy, L., Castro, J., Hannig, G., & Brierley, S. (2020). CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 158 (pp. S803). Austin, TX: W B SAUNDERS CO-ELSEVIER INC. WoS1
2019	Castro, J., Harrington, A., Maddern, J., Schober, G., Grundy, L. A., Ge, P., . . . Brierley, S. (2019). CHRONIC INTRACOLONIC ADMINISTRATION OF LINACLOTIDE INHIBITS NOCICEPTIVE SIGNALING IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S570). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS2
2019	Grundy, L., Castro, J., Maddern, J., Harrington, A., Hannig, G., Ge, P., & Brierley, S. (2019). CHRONIC COLONIC ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT HYPERACTIVITY. In GASTROENTEROLOGY Vol. 156 (pp. S363). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS1
2019	Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A. L., Lindstrom, B., Adams, J., & Brierley, S. (2019). OLORINAB (FORMERLY APD371), A PERIPHERALLY RESTRICTED, HIGHLY SELECTIVE, FULL AGONIST OF THE CANNABINOID RECEPTOR 2 (CB<sub>2</sub>), REDUCES VISCERAL HYPERSENSITIVITY IN ANIMAL MODELS. In GASTROENTEROLOGY Vol. 156 (pp. S382). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS4
2019	Castro, J., Maddern, J., Garcia-Caraballo, S., Lumsden, A., Lindstrom, B., Adams, J., & Brierley, S. M. (2019). Olorinab (APD371), a peripherally restricted, highly selective, full agonist of the cannabinoid receptor type 2 (CB<sub>2</sub>), reduces visceral hypersensitivity in animal models. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 31 (pp. 2 pages). WILEY.
2018	Uhlig, F., Grundy, L., Castro, J., Brierley, S. M., Foster, S. J., & Grundy, D. (2018). Identification of modulators of intestinal nerve activity from <i>Staphylococcus aureus</i>. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
2018	Erickson, A., Garcia-Caraballo, S., Castro, J., Grundy, L., Rychkov, G., Vetter, I., . . . Brierley, S. (2018). Role of voltage-gated sodium channel isoforms in colon-innervating neurons in mice. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY.
2018	Grundy, L., Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Rychkov, G., & Brierley, S. (2018). Colitis-induced chronic colonic hypersensitivity induces cross organ sensitisation of bladder afferent pathways. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. WoS1
2018	Brierley, S., Castro, J., Maddern, J., Garcia-Caraballo, S., Lindstrom, B., & Adams, J. (2018). APD371, a peripherally restricted, highly selective, full agonist of the Cannabinoid Receptor 2 (CB2), reduces colitis-induced visceral hypersensitivity in rats. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 2 pages). WILEY.
2017	Grundy, L. A., Castro, J., Harrington, A., Peters, S., Feil, R., Miller, P., . . . Brierley, S. (2017). EXTRACELLULAR CGMP REDUCES THE EXCITABILITY OF SENSORY DORSAL ROOT GANGLION NEURONS VIA AN EXTRACELLULAR MECHANISM. In GASTROENTEROLOGY Vol. 152 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. DOI WoS1
2015	Castro, J., Harrington, A. M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., . . . Brierley, S. M. (2015). A Visceral Representation of Itch: Identification 'Itch-Specific' Pruritogenic Mechanisms Within Colonic Sensory Pathways. In GASTROENTEROLOGY Vol. 148 (pp. S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015	Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). GC-C Agonists As Regulators of Visceral Sensation: Modulation of Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway. In GASTROENTEROLOGY Vol. 148 (pp. S732-S733). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2015	Castro, J., Harrington, A. M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., . . . Brierley, S. M. (2015). Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending Nociceptive Pathways and Restores Aberrant Spinal Cord Signaling. In GASTROENTEROLOGY Vol. 148 (pp. S194). Washington, DC: W B SAUNDERS CO-ELSEVIER INC.
2014	Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C. B., Silos-Santiago, I., & Brierley, S. M. (2014). Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released in Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion (DRG) Neurons. In GASTROENTEROLOGY Vol. 146 (pp. S722). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2014	Harrington, A. M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D. J., & Brierley, S. M. (2014). α-Conotoxin Vc1.1 Targets GABAB Receptors Modulating CaV2.2 and CaV2.3 Calcium Channels in Sensory Pathways Mediating Chronic Visceral Pain. In GASTROENTEROLOGY Vol. 146 (pp. S156). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2013	Castro, J., Harrington, A. M., Mann, E. A., Cohen, M. B., Kurtz, C. B., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms Underlying Linaclotide Induced Inhibition of Colonic Nociception. In GASTROENTEROLOGY Vol. 144 (pp. S134). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013	Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, A., Nguyen, N. Q., . . . Brierley, S. M. (2013). Alterations in the Guanylate Cyclase-C/cGMP Pathway in Patients With Irritable Bowel Syndrome With Constipation. In GASTROENTEROLOGY Vol. 144 (pp. S59-S60). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2013	Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012	Castro, J., Harrington, A. M., Hughes, P. A., Martin, C., Silos-Santiago, A., Kurtz, C. B., . . . Brierley, S. M. (2012). Mechanism of Action for Linaclotide Induced Abdominal Pain Relief. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. WoS5
2012	Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012	Castro, J., Harrington, A. M., Page, A. J., & Brierley, S. M. (2012). Downstream Signaling Pathways of Nitric Oxide Induced Modulation of Colonic Afferent Mechanosensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S697). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2011	Castro, J., Martin, C., Hughes, P. A., Silos-Santiago, A., Kurtz, C. B., Blackshaw, L. A., & Brierley, S. M. (2011). A Novel Role of Cyclic GMP in Colonic Sensory Neurotransmission in Healthy and TNBS-Treated Mice. In GASTROENTEROLOGY Vol. 140 (pp. S538). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS18
2011	Castro, J., Harrington, A., Hughes, P. A., Martin, C., Page, A. J., Blackshaw, L. A., & Brierley, S. M. (2011). Nitric Oxide Mechanism of Action on Visceral Nociceptors. In GASTROENTEROLOGY Vol. 140 (pp. S536). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011	Harrington, A., Brierley, S. M., Castro, J., Hughes, P. A., & Blackshaw, L. A. (2011). Identification of Colonic Afferent Central Terminals and Changes Following Colonic Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S131). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC.
2011	Castro, J., Balemba, O. B., Blackshaw, L. A., & Brierley, S. M. (2011). Garcinia Buchananii Bark Extract Inhibits Nociceptors, With Greater Efficacy During Inflammation. In GASTROENTEROLOGY Vol. 140 (pp. S866). Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS7
2010	Hughes, P., Brierley, S., Harrington, A., Castro, J., Martin, C., & Blackshaw, L. (2010). Differential coupling of cytokine receptors to sensory neurons in health and post inflammation. In Proceedings Vol. 138 (pp. 136-137). W B SAUNDERS CO-ELSEVIER INC. DOI

Conference Items

Year	Citation
2020	Castro, J., Maddern, J., Garcia-Caraballo, S., Schober, G., Lindstrom, B., Schmiel, S., & Brierley, S. M. (2020). Olorinab, a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2 (CB2), reduces visceral hypersensitivity in mice. Poster session presented at the meeting of Abstracts of the 4th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2020), as published in Neurogastroenterology & Motility. Adelaide Convention Centre, Adelaide, Australia: Wiley. DOI
2019	Grundy, L., Harrington, A., Caldwell, A., Castro, J., Zagorodnyuk, V., Brookes, S., . . . Brierley, S. (2019). Low and high threshold mechanosensitive bladder afferent pathways converge to a similar distribution of lumbosacral spinal neurons. Poster session presented at the meeting of Abstracts of the 114th Annual Meeting of the American Urological Association (AUA), as published in Journal of Urology. Chicago, IL: Wolters Kluwer Health. DOI
2017	Castro, J., Deiteren, A., Harrington, A., Maddern, J., Moore, J., Garcia-Caraballo, S., . . . Brierley, S. (2017). Chronic oral administration of linaclotide inhibits nociceptive signalling in response to noxious colorectal distension in a model of chronic visceral hypersensitivity. Poster session presented at the meeting of Abstracts of the Digestive Disease Week (DDW) 2017, as published in Gastroenterology. Chicago, IL: Elsevier. DOI WoS1
2017	Deiteren, A., Doms, S., Castro, J., Garcia-Caraballo, S., Ostertag, D., & Brierley, S. (2017). The histamine receptor H4 is functionally expressed on murine colonic sensory neurons and contributes to chronic visceral hypersensitivity. Poster session presented at the meeting of Abstracts of the NeuroGASTRO 2017 Congress, as published in Neurogastroenterology and Motility. Cork, Ireland: Wiley. DOI
2016	Carstens, B., Berecki, G., Daniel, J., Lee, H. S., Jackson, K., Tae, H. -S., . . . Clark, R. (2016). MINIATURISED ALPHA-CONOTOXINS FOR THE TREATMENT OF PAIN. Poster session presented at the meeting of JOURNAL OF PEPTIDE SCIENCE. WILEY.
2016	Garcia-Caraballo, S., Harrington, A. M., Castro, J., Hannig, G., Kurtz, C., Silos-Santiago, A., . . . Brierley, S. M. (2016). Guanylate cyclase-C expression is down-regulated in colonic biopsies from female irritable bowel syndrome patients with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2016	Garcia-Carraballo, S., Harrington, A., Castro, J., Hannig, G., Kurtz, C. B., Silos-Santiago, A., . . . Brierley, S. (2016). Guanylate Cyclase-C Expression Is Down-Regulated in Colonic Biopsies From Female Irritable Bowel Syndrome Patients With Constipation. Poster session presented at the meeting of GASTROENTEROLOGY. San Diego, CA: W B SAUNDERS CO-ELSEVIER INC. DOI WoS2
2014	Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2014). Distinct alterations in the guanylate cyclase-C/cGMP pathway are evident across different subtypes of irritable bowel syndrome patients. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons. DOI
2014	Castro, J., Rychkov, G. Y., Ghetti, A., Harrington, A. M., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2014). Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons. Poster session presented at the meeting of Neurogastroenterology and Motility. Guangzhou, China: John Wiley and Sons. DOI WoS1
2014	Harrington, A. M., Castro, J., Young, R. L., Kurtz, C. B., Silos-Santiago, I., Nguyen, N. Q., . . . Brierley, S. M. (2014). Distinct Alterations in the Guanylate Cyclase-C (GC-C)/Cyclic GMP (cGMP) Pathway Are Evident Across Different Subtypes of Irritable Bowel Syndrome (IBS) Patients. Poster session presented at the meeting of GASTROENTEROLOGY. Chicago, IL: W B SAUNDERS CO-ELSEVIER INC. WoS3
2013	Harrington, A. M., Castro, J., Young, R. L., Kurtz, C., Silos-Santiago, A., Nguyen, N., . . . Brierley, S. M. (2013). The guanylatecyclase-c/CGMP pathway is altered in patients with irritable bowel syndrome with constipation. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL. DOI
2013	Hannig, G., Castro, J., Harrington, A., Ge, P., Jin, H., Kessler, M. M., . . . Silos-Santiago, I. (2013). Activation of the guanylate cyclase-C/cGMP pathway decreases gastrointestinal pain. Poster session presented at the meeting of Journal of Gastroenterology and Hepatology. Shanghai, China: Wiley. DOI
2013	Harrington, A. M., Castro, J., & Brierley, S. M. (2013). Peripheral modulation of TRPA1 alters dorsal horn neuron activation to colorectal distension. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY.
2013	Castro, J., Harrington, A. M., & Brierley, S. M. (2013). TRPV3 contributes to chronic visceral mechanical hypersensitivity. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, California: Wiley-Blackwell. DOI
2013	Castro, J., Harrington, A. M., Mann, E., Cohen, M. B., Kurtz, C., Silos-Santiago, A., & Brierley, S. M. (2013). Mechanisms of linaclotide-induced inhibition of colonic nociception. Poster session presented at the meeting of Abstracts of the 17th American Neurogastroenterology and Motility Society Annual Scientific Meeting, as published in Neurogastroenterology & Motility. Huntington Beach, CA: Wiley-Blackwell. DOI
2013	Brierley, S. M., Castro, J., Harrington, A., Hughes, P., Martin, C., Silos-Santiago, A., . . . Blackshaw, A. (2013). MECHANISM OF ACTION FOR LINACLOTIDE-INDUCED ABDOMINAL PAIN RELIEF. Poster session presented at the meeting of GUT. Glasgow, SCOTLAND: BMJ PUBLISHING GROUP. DOI
2011	Castro, J., Hughes, P. A., Martin, C. M., Silos-Santiago, A., Kurtz, C., Black-Shaw, L. A., & Brierley, S. M. (2011). Extracellular cGMP has contrasting effects on colonic afferent mechanosensitivity in control and tnbs-treated mice. Poster session presented at the meeting of NEUROGASTROENTEROLOGY AND MOTILITY. WILEY-BLACKWELL.
2010	Brierley, S., Castro Kraftchenko, J., Martin, C., Harrington, A., Hughes, P., & Blackshaw, L. (2010). Differential regulation of TRP channel function in acute and chronic mechanical hypersensitivity. Poster session presented at the meeting of Abstract of theJoint International Neurogastroenterology and Motility Meeting, as published in Neurogastroenterology and Motility. Boston, MA, USA: Wiley-Blackwell Publishing. DOI
2008	Castro, J., Aromataris, E., Barritt, G., & Rychkov, G. (2008). Differential effects of cholestatic and choleretic bile acids on store-operated Ca2+ channels in liver [Abstract]. Poster session presented at the meeting of Abstracts of the sixty-second annual meeting of the Society of General Physiologists in Journal of General Physiology. Massachusetts, USA: Rockefeller University Press.
2008	Aromataris, E. C., Castro, J., Rychkov, G. Y., & Barritt, G. J. (2008). Bile acids modulate store-operated CA2+ channels and stromal interaction molecule1 (STIM1) distribution in liver cells. Poster session presented at the meeting of Abstracts of the 43rd Annual Meeting of the European Association for the Study of the Liver, as published in Journal of Hepatology. Milan, Italy: Elsevier Science. DOI

Preprint

Year	Citation
2022	Castro, J., Maddern, J., Chow, C. Y., Tran, P., Vetter, I., King, G., & Brierley, S. (2022). The voltage-gated sodium channel Na<sub>V</sub>1.7 underlies endometriosis-associated chronic pelvic pain. DOI
2022	Bayrer, J., Castro, J., Venkataraman, A., Touhara, K., Rossen, N., Morrie, R., . . . Julius, D. (2022). Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety. DOI
2020	Grundy, L., Caldwell, A., Garcia-Caraballo, S., Grundy, D., Spencer, N., Dong, X., . . . Brierley, S. (2020). Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. DOI

As a principal investigator:

2024-2027: NHMRC Ideas Grant APP2029332 (Castro, PI). “Validation of a novel immunotherapeutic approach to treat chronic pelvic pain in endometriosis ”. Goal: Pre-clinical studies to validate of a new treatment for endometriosis based on a monoclonal antibody clinically approved to treat ovarian cancer.
2020-2024: NHMRC Ideas Grant APP1181448 (Castro, PI). “Decoding the pathophysiology of chronic pelvic pain associated with endometriosis and related visceral comorbidities”. Goal: Using clinically relevant models of endometriosis in combination with human samples, to identify novel mechanisms driving chronic pelvic pain in endometriosis.
2021-2022: Endometriosis Australia Foundation Research Grant (Castro, PI). “Identifying inflammatory mediators secreted by the endometrium of women with endometriosis, relevant to pain transmission from visceral organs”. Goal: Using clinically relevant models of endometriosis in combination with human samples, to identify novel mechanisms driving chronic pelvic pain in endometriosis.
2020-2021: Flinders Medical Foundation Grant as sole CIA (Castro, PI). “Developing a in vivo technique to investigate endometriosis-related chronic pelvic pain”. Goal: Seed grant to help developing an assay to measure the activity of sensory neurons within intact Dorsal Root Ganglia in vivo (intra-vital imaging)

As a Co-investigator:

2022-2024: Pain Management Grant with The Hospital Research Foundation Group (Wardill, Mrozik, Lynn, and Castro). “Does the gut microbiota play an important role in mediating the painful side effects of cancer treatment?”
2021-2022: Innovation Grant Scheme. Department of Obstetrics and Gynaecology, University of Melbourne CIs: Sarah Holdsworth-Carson, Dr Joel Castro, A/Prof Berin Boughton, Dr Jane Girling.
2020-2021: H.S and J.C Anderson Charitable Trust. Dr Jane Girling, A/Prof Rebecca Campbell, Dr Joel Castro, Dr Sarah Holdsworth-Carson
2010-present: Industry support from Ironwood Pharmaceuticals, to determine novel treatments for chronic abdominal pain associated with IBS.

Research Only

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2015 - 2019	External Supervisor	Role of Voltage-gated Sodium Channel Isoforms in Electrophysiological Properties of Neurons Innervating the Viscera in Mice	Doctor of Philosophy	Doctorate	Full Time	Ms Andelain Erickson

Email: joel.castrokraftchenko@adelaide.edu.au

Joel Castro Kraftchenko

Appointments

Language Competencies

Education

Research Interests