João Aguiar Macedo Teixeira

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

My Research
Career
Publications
Supervision
Contact

I am a population geneticist focusing on the evolution of humans and closely related species. I work across a wide range of topics at the forefront of modern human evolutionary genetics, including demographic inference, comparative genomics and natural selection.

Currently, my main research focus revolves around human evolution during the Pleistocene, in particular the admixture events between so-called modern and archaic humans after the out-of-Africa and before human colonisation of Sahul.

I am expert on uncovering signatures of natural selection in the genome, in particular balancing selection, and continue to study how advantageous genetic diversity can be maintained for millions of years in natural populations.

Language Competencies

Language	Competency
English	Can read, write, speak, understand spoken and peer review
French	Can read, speak and understand spoken
Portuguese	Can read, write, speak, understand spoken and peer review
Spanish; Castilian	Can read, write, speak and understand spoken

Education

Date	Institution name	Country	Title
2012 - 2016	Max Planck Institute for Evolutionary Anthropology	Germany	PhD in Evolutionary Genetics
	University of Porto	Portugal	MSc Forensic and Population Genetics

Research Interests

Anthropological Genetics Applied Statistics Bioinformatics Evolutionary Biology Population, Ecological and Evolutionary Genetics

Journals

Year	Citation
2025	Roca-Rada, X., Cuesta-Aguirre, D. R., Vinueza-Espinosa, D. C., Davidson, R., Ravishankar, S., Taufik, L., . . . Santos, C. (2025). Genetic transitions in the Neolithic and Bronze Age at Mas d’en Boixos (Catalonia, Spain). iScience, 28(7), 112871-1-112871-11. DOI Scopus1 WoS1 Europe PMC1
2025	Davidson, R., Roca-Rada, X., Ravishankar, S., Taufik, L., Haarkötter, C., Collen, E., . . . Llamas, B. (2025). Optimized in-solution enrichment of over a million ancient human SNPs. Genome Biology, 26(1), 190-1-190-20. DOI Scopus2 WoS2 Europe PMC3
2025	Purnomo, G. A., Teixeira, J. C., Sudoyo, H., Llamas, B., & Tobler, R. (2025). Benchmarking Imputed Low Coverage Genomes in a Human Population Genetics Context. Molecular Ecology Resources, e70007-1-e70007-12. DOI
2025	Singh, P., Teixeira, J. C., Weber, M. E., Bolch, C., & Armbrecht, L. (2025). Enhanced sedimentary ancient DNA (sedaDNA) retrieval from Antarctic diatoms. Marine Micropaleontology, 199, 102477. DOI
2025	Roca-Rada, X., Davidson, R., Williams, M. P., Villalba-Mouco, V., Carvalho, A. F., Ravishankar, S., . . . Teixeira, J. C. (2025). The genetic history of Portugal over the past 5,000 years.. Genome Biology, 26(1), 248-1-248-39. DOI Europe PMC1
2024	Rohrlach, A. B., Rivollat, M., de-Miguel-Ibáñez, P., Moilanen, U., Liira, A. -M., Teixeira, J. C., . . . Prüfer, K. (2024). Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA. Nature Communications, 15(1), 1294-1-1294-8. DOI Scopus8 WoS9 Europe PMC8
2024	MacRoberts, R. A., Liberato, M., Roca-Rada, X., Valente, M. J., Relvado, C., Matos Fernandes, T., . . . Maurer, A. -F. (2024). Shrouded in history: Unveiling the ways of life of an early Muslim population in Santarém, Portugal (8th- 10th century AD). PLoS One, 19(3), e0299958-1-e0299958-44. DOI Scopus3 WoS2 Europe PMC2
2024	Singh, P., Teixeira, J. C., Bolch, C., & Armbrecht, L. (2024). Marine sedimentary ancient DNA from Antarctic diatoms. Palaeogeography, Palaeoclimatology, Palaeoecology, 640, 112090-1-112090-9. DOI Scopus3 WoS2
2024	Purnomo, G. A., Kealy, S., O'Connor, S., Schapper, A., Shaw, B., Llamas, B., . . . Tobler, R. (2024). The genetic origins and impacts of historical Papuan migrations into Wallacea. Proceedings of the National Academy of Sciences of USA, 121(52), e2412355121. DOI Scopus2 WoS2
2024	Teixeira, J. C. (2024). Ancient DNA: a direct window into the human past. Antropologia Portuguesa, 41(41), 297-312. DOI
2024	Burton, C. A., Kelley, D. I., Burke, E., Mathison, C., Jones, C. D., Betts, R. A., . . . Anderson, L. O. (2024). Fire weakens land carbon sinks before 1.5 °C. NATURE GEOSCIENCE, 17(11), 10 pages. DOI WoS5
2023	Taufik, L., Teixeira, J. C., Llamas, B., Sudoyo, H., Tobler, R., & Purnomo, G. A. (2023). Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects. Genes, 13(12), 1-11. DOI Scopus5 WoS4 Europe PMC3
2022	Collen, E. J., Johar, A. S., Teixeira, J. C., & Llamas, B. (2022). The immunogenetic impact of European colonization in the Americas. Frontiers in Genetics, 13, 918227-1-918227-12. DOI Scopus8 WoS7 Europe PMC4
2022	Roca-Rada, X., Tereso, S., Rohrlach, A. B., Brito, A., Williams, M. P., Umbelino, C., . . . Teixeira, J. C. (2022). A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics.. Lancet (London, England), 400(10353), 691-692. DOI Scopus11 WoS10 Europe PMC5
2022	Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., . . . Huber, C. D. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, 6(12), 2003-2015. DOI Scopus17 WoS17 Europe PMC25
2021	Teixeira, J. C., & Huber, C. D. (2021). The inflated significance of neutral genetic diversity in conservation genetics. Proceedings of the National Academy of Sciences, 118(10), e2015096118. DOI Scopus313 WoS302 Europe PMC200
2021	Aguiar Macedo Teixeira, J. C., Jacobs, G. S., Stringer, C., Tuke, S., Hudjashov, G., Purnomo, G. A., . . . Helgen, K. M. (2021). Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture. Nature Ecology & Evolution, 5(5), 616-624. DOI Scopus35 WoS28 Europe PMC15
2021	Roca-Rada, X., Politis, G., Messineo, P. G., Scheifler, N., Scabuzzo, C., Gonzalez, M., . . . Fehren-Schmitz, L. (2021). Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America. iScience, 24(6), 1-18. DOI Scopus18 WoS20 Europe PMC7
2021	Purnomo, G. A., Mitchell, K. J., O'Connor, S., Kealy, S., Taufik, L., Schiller, S., . . . Tobler, R. (2021). Mitogenomes reveal two major influxes of Papuan ancestry across Wallacea following the last glacial maximum and Austronesian contact. Genes, 12(7), 1-21. DOI Scopus22 WoS22 Europe PMC13
2021	Teixeira, J. C., & Huber, C. D. (2021). Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology. Conservation Genetics, 22(4), 547-549. DOI Scopus2 WoS2
2020	Williams, M., & Teixeira, J. (2020). A genetic perspective on human origins. Biochemist, 42(1), 6-10. DOI Scopus4
2020	O'Neill, M. B., Laval, G., Aguiar Macedo Teixeira, J., Palmenberg, A. C., & Pepperell, C. S. (2020). Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years. Human molecular genetics, 29(5), 736-744. DOI Scopus9 WoS7 Europe PMC7
2020	Barquera, R., Collen, E., Di, D., Buhler, S., Aguiar Macedo Teixeira, J., Llamas, B., . . . Sanchez-Mazas, A. (2020). Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide. HLA, 96(3), 277-298. DOI Scopus82 WoS79 Europe PMC75
2020	Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S., Schmidt, J., . . . Cooper, A. (2020). Ancient human genomes reveal a hidden history of strong selection in Eurasia. DOI
2020	Roca-Rada, X., Souilmi, Y., Teixeira, J. C., & Llamas, B. (2020). Ancient DNA studies in pre-Columbian Mesoamerica. Genes, 11(11), 1-19. DOI Scopus7 WoS6 Europe PMC3
2019	Teixeira, J., & Cooper, A. (2019). A ‘Denisovan’ genetic history of recent human evolution. DOI
2019	Teixeira, J. C., & Cooper, A. (2019). Using hominin introgression to trace modern human dispersals. Proceedings of the National Academy of Sciences, 116(31), 15327-15332. DOI Scopus32 WoS28 Europe PMC19
2018	Bitarello, B. D., de Filippo, C., Teixeira, J. C., Schmidt, J. M., Kleinert, P., Meyer, D., & Andrés, A. M. (2018). Signatures of Long-Term Balancing Selection in Human Genomes. Genome Biology and Evolution, 10(3), 939-955. DOI Scopus88 WoS86 Europe PMC85
2015	Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Reply to letter from Felice L. Bedford and Doron Yacobi. European Journal of Human Genetics, 23(8), 994-995. DOI
2015	Nogueiro, I., Teixeira, J. C., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Portuguese crypto-Jews: the genetic heritage of a complex history. Frontiers in Genetics, 6(FEB), 1-12. DOI Scopus9 WoS11 Europe PMC6
2015	Teixeira, J. C., de Filippo, C., Weihmann, A., Meneu, J. R., Racimo, F., Dannemann, M., . . . Andrés, A. M. (2015). Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos. Molecular Biology and Evolution, 32(5), 1186-1196. DOI Scopus61 WoS60 Europe PMC62
2015	Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants. European Journal of Human Genetics, 23(5), 693-699. DOI Scopus13 WoS14 Europe PMC7
2014	Key, F. M., Teixeira, J. C., de Filippo, C., & Andrés, A. M. (2014). Advantageous diversity maintained by balancing selection in humans. Current Opinion in Genetics & Development, 29, 45-51. DOI Scopus81 WoS81 Europe PMC75
2011	Teixeira, J. C., Nogueiro, I., Goios, A., Gusmão, L., Amorim, A., & Alvarez, L. (2011). Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community. Forensic Science International Genetics Supplement Series, 3(1), e51-e52. DOI Scopus5 WoS6
2005	Vilarinho, L., Cardoso, M. L., Gaspar, P., Barbot, C., Azevedo, L., Diogo, L., . . . Jakobs, C. (2005). Novel L2HGDH mutations in 21 patients with L-2-hydroxyglutaric aciduria of Portuguese origin.. Human Mutation, 26(4), 395-396. DOI Scopus32 Europe PMC29

Conference Papers

Year	Citation
2016	Andres, A. M., Dannemann, M., Teixeira, J., & Kelso, J. (2016). Balancing selection and adaptive introgression as sources of advantageous genetic diversity in populations. In AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY Vol. 159 (pp. 80-81). Atlanta, GA: WILEY-BLACKWELL.

Conference Items

Year	Citation
2020	Teixeira, J. C. (2020). Hominin introgression in Island Southeast Asia and Sahul. Poster session presented at the meeting of American Journal of Physical Anthropology. Los Angeles, CA: Wiley. DOI

Preprint

Year	Citation
2024	Davidson, R., Roca-Rada, X., Ravishankar, S., Taufik, L., Haarkötter, C., Collen, E., . . . Llamas, B. (2024). Optimised in-solution enrichment of over a million ancient human SNPs. DOI Europe PMC2
2024	Purnomo, G., Kealy, S., O’Connor, S., Schapper, A., Shaw, B., Llamas, B., . . . Tobler, R. (2024). The genetic origins and impacts of historical Papuan migrations into Wallacea. DOI
2024	Purnomo, G., Teixeira, J., Sudoyo, H., Llamas, B., & Tobler, R. (2024). Benchmarking Imputed Low Coverage Genomes in a Human Population Genetics Context. DOI
2024	Roca-Rada, X., Davidson, R., Williams, M., Ravishankar, S., Collen, E., Haarkötter, C., . . . Teixeira, J. (2024). The genetic history of Portugal over the past 5,000 years. DOI

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2020 - 2022	Co-Supervisor	Post-contact evolutionary immunogenetics in Indigenous peoples of America	Doctor of Philosophy	Doctorate	Full Time	Ms Evelyn Jane Collen
2019 - 2022	Co-Supervisor	Human demographic insights from paleogenetic studies of American and Iberian skeletal remains	Doctor of Philosophy	Doctorate	Full Time	Mr Xavier Roca Rada
2018 - 2022	Co-Supervisor	Reconstructing the Population History of Wallacea and Sahul	Doctor of Philosophy	Doctorate	Full Time	Dr Gludhug Ariyo Purnomo

Email: joao.teixeira@adelaide.edu.au