João Aguiar Macedo Teixeira
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am a population geneticist focusing on the evolution of humans and closely related species. I work across a wide range of topics at the forefront of modern human evolutionary genetics, including demographic inference, comparative genomics and natural selection.
Currently, my main research focus revolves around human evolution during the Pleistocene, in particular the admixture events between so-called modern and archaic humans after the out-of-Africa and before human colonisation of Sahul.
I am expert on uncovering signatures of natural selection in the genome, in particular balancing selection, and continue to study how advantageous genetic diversity can be maintained for millions of years in natural populations.
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Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review French Can read, speak and understand spoken Portuguese Can read, write, speak, understand spoken and peer review Spanish; Castilian Can read, write, speak and understand spoken -
Education
Date Institution name Country Title 2012 - 2016 Max Planck Institute for Evolutionary Anthropology Germany PhD in Evolutionary Genetics University of Porto Portugal MSc Forensic and Population Genetics -
Research Interests
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Journals
Year Citation 2024 Rohrlach, A. B., Rivollat, M., de-Miguel-Ibáñez, P., Moilanen, U., Liira, A. -M., Teixeira, J. C., . . . Prüfer, K. (2024). Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA. Nature Communications, 15(1), 1294-1-1294-8.
Scopus6 Europe PMC52024 MacRoberts, R. A., Liberato, M., Roca-Rada, X., Valente, M. J., Relvado, C., Matos Fernandes, T., . . . Maurer, A. -F. (2024). Shrouded in history: Unveiling the ways of life of an early Muslim population in Santarém, Portugal (8th- 10th century AD). PLoS One, 19(3), e0299958-1-e0299958-44.
Scopus2 Europe PMC12024 Singh, P., Teixeira, J. C., Bolch, C., & Armbrecht, L. (2024). Marine sedimentary ancient DNA from Antarctic diatoms. Palaeogeography, Palaeoclimatology, Palaeoecology, 640, 112090-1-112090-9.
Scopus12024 Purnomo, G. A., Kealy, S., O'Connor, S., Schapper, A., Shaw, B., Llamas, B., . . . Tobler, R. (2024). The genetic origins and impacts of historical Papuan migrations into Wallacea. Proceedings of the National Academy of Sciences of USA, 121(52), e2412355121.
2024 Teixeira, J. C. (2024). Ancient DNA: a direct window into the human past. Antropologia Portuguesa, 41(41), 297-312.
2024 Burton, C. A., Kelley, D. I., Burke, E., Mathison, C., Jones, C. D., Betts, R. A., . . . Anderson, L. O. (2024). Fire weakens land carbon sinks before 1.5 °C. NATURE GEOSCIENCE, 17(11), 10 pages.
2023 Taufik, L., Teixeira, J. C., Llamas, B., Sudoyo, H., Tobler, R., & Purnomo, G. A. (2023). Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects. Genes, 13(12), 1-11.
Scopus3 Europe PMC32022 Collen, E. J., Johar, A. S., Teixeira, J. C., & Llamas, B. (2022). The immunogenetic impact of European colonization in the Americas. Frontiers in Genetics, 13, 918227-1-918227-12.
Scopus5 Europe PMC12022 Roca-Rada, X., Tereso, S., Rohrlach, A. B., Brito, A., Williams, M. P., Umbelino, C., . . . Teixeira, J. C. (2022). A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics.. Lancet (London, England), 400(10353), 691-692.
Scopus10 WoS1 Europe PMC42022 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., . . . Huber, C. D. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, 6(12), 2003-2015.
Scopus14 WoS3 Europe PMC202021 Teixeira, J. C., & Huber, C. D. (2021). The inflated significance of neutral genetic diversity in conservation genetics. Proceedings of the National Academy of Sciences, 118(10), e2015096118.
Scopus283 WoS158 Europe PMC1482021 Aguiar Macedo Teixeira, J. C., Jacobs, G. S., Stringer, C., Tuke, S., Hudjashov, G., Purnomo, G. A., . . . Helgen, K. M. (2021). Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture. Nature Ecology & Evolution, 5(5), 616-624.
Scopus30 WoS18 Europe PMC142021 Roca-Rada, X., Politis, G., Messineo, P. G., Scheifler, N., Scabuzzo, C., Gonzalez, M., . . . Fehren-Schmitz, L. (2021). Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America. iScience, 24(6), 1-18.
Scopus15 WoS12 Europe PMC42021 Purnomo, G. A., Mitchell, K. J., O'Connor, S., Kealy, S., Taufik, L., Schiller, S., . . . Tobler, R. (2021). Mitogenomes reveal two major influxes of Papuan ancestry across Wallacea following the last glacial maximum and Austronesian contact. Genes, 12(7), 1-21.
Scopus20 WoS12 Europe PMC112021 Teixeira, J. C., & Huber, C. D. (2021). Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology. Conservation Genetics, 22(4), 547-549.
Scopus2 WoS12020 Williams, M., & Teixeira, J. (2020). A genetic perspective on human origins. Biochemist, 42(1), 6-10.
Scopus32020 O'Neill, M. B., Laval, G., Aguiar Macedo Teixeira, J., Palmenberg, A. C., & Pepperell, C. S. (2020). Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years. Human molecular genetics, 29(5), 736-744.
Scopus9 WoS5 Europe PMC72020 Barquera, R., Collen, E., Di, D., Buhler, S., Aguiar Macedo Teixeira, J., Llamas, B., . . . Sanchez-Mazas, A. (2020). Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide. HLA, 96(3), 277-298.
Scopus80 WoS57 Europe PMC702020 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S., Schmidt, J., . . . Cooper, A. (2020). Ancient human genomes reveal a hidden history of strong selection in Eurasia.
2020 Roca-Rada, X., Souilmi, Y., Teixeira, J. C., & Llamas, B. (2020). Ancient DNA studies in pre-Columbian Mesoamerica. Genes, 11(11), 1-19.
Scopus7 WoS4 Europe PMC32019 Teixeira, J., & Cooper, A. (2019). A ‘Denisovan’ genetic history of recent human evolution.
2019 Teixeira, J. C., & Cooper, A. (2019). Using hominin introgression to trace modern human dispersals. Proceedings of the National Academy of Sciences, 116(31), 15327-15332.
Scopus30 WoS18 Europe PMC162018 Bitarello, B. D., de Filippo, C., Teixeira, J. C., Schmidt, J. M., Kleinert, P., Meyer, D., & Andrés, A. M. (2018). Signatures of Long-Term Balancing Selection in Human Genomes. Genome Biology and Evolution, 10(3), 939-955.
Scopus81 WoS67 Europe PMC662015 Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Reply to letter from Felice L. Bedford and Doron Yacobi. European Journal of Human Genetics, 23(8), 994-995.
2015 Nogueiro, I., Teixeira, J. C., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Portuguese crypto-Jews: the genetic heritage of a complex history. Frontiers in Genetics, 6(FEB), 1-12.
Scopus9 WoS9 Europe PMC62015 Teixeira, J. C., de Filippo, C., Weihmann, A., Meneu, J. R., Racimo, F., Dannemann, M., . . . Andrés, A. M. (2015). Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos. Molecular Biology and Evolution, 32(5), 1186-1196.
Scopus60 WoS53 Europe PMC552015 Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants. European Journal of Human Genetics, 23(5), 693-699.
Scopus13 WoS14 Europe PMC72014 Key, F. M., Teixeira, J. C., de Filippo, C., & Andrés, A. M. (2014). Advantageous diversity maintained by balancing selection in humans. Current Opinion in Genetics & Development, 29, 45-51.
Scopus77 WoS74 Europe PMC682011 Teixeira, J. C., Nogueiro, I., Goios, A., Gusmão, L., Amorim, A., & Alvarez, L. (2011). Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community. Forensic Science International: Genetics Supplement Series, 3(1), E51-E52.
Scopus5 WoS62005 Vilarinho, L., Cardoso, M. L., Gaspar, P., Barbot, C., Azevedo, L., Diogo, L., . . . Jakobs, C. (2005). Novel L2HGDH mutations in 21 patients with L-2-hydroxyglutaric aciduria of Portuguese origin.. Human mutation, 26(4), 395-396.
Scopus30 Europe PMC27 -
Conference Papers
Year Citation 2016 Andres, A. M., Dannemann, M., Teixeira, J., & Kelso, J. (2016). Balancing selection and adaptive introgression as sources of advantageous genetic diversity in populations. In AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY Vol. 159 (pp. 80-81). Atlanta, GA: WILEY-BLACKWELL. -
Conference Items
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Preprint
Year Citation 2024 Davidson, R., Roca-Rada, X., Ravishankar, S., Taufik, L., Haarkötter, C., Collen, E., . . . Llamas, B. (2024). Optimised in-solution enrichment of over a million ancient human SNPs.
DOI Europe PMC22024 Purnomo, G., Kealy, S., O’Connor, S., Schapper, A., Shaw, B., Llamas, B., . . . Tobler, R. (2024). The genetic origins and impacts of historical Papuan migrations into Wallacea.
DOI2024 Purnomo, G., Teixeira, J., Sudoyo, H., Llamas, B., & Tobler, R. (2024). Benchmarking Imputed Low Coverage Genomes in a Human Population Genetics Context.
DOI2024 Roca-Rada, X., Davidson, R., Williams, M., Ravishankar, S., Collen, E., Haarkötter, C., . . . Teixeira, J. (2024). The genetic history of Portugal over the past 5,000 years.
DOI
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 - 2022 Co-Supervisor Post-contact evolutionary immunogenetics in Indigenous peoples of America Doctor of Philosophy Doctorate Full Time Ms Evelyn Jane Collen 2019 - 2022 Co-Supervisor Human demographic insights from paleogenetic studies of American and Iberian skeletal remains Doctor of Philosophy Doctorate Full Time Mr Xavier Roca Rada 2018 - 2022 Co-Supervisor Reconstructing the Population History of Wallacea and Sahul Doctor of Philosophy Doctorate Full Time Dr Gludhug Ariyo Purnomo
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