João Aguiar Macedo Teixeira
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am a population geneticist focusing on the evolution of humans and closely related species. I work across a wide range of topics at the forefront of modern human evolutionary genetics, including demographic inference, comparative genomics and natural selection.
Currently, my main research focus revolves around human evolution during the Pleistocene, in particular the admixture events between so-called modern and archaic humans after the out-of-Africa and before human colonisation of Sahul.
I am expert on uncovering signatures of natural selection in the genome, in particular balancing selection, and continue to study how advantageous genetic diversity can be maintained for millions of years in natural populations.
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Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review French Can read, speak and understand spoken Portuguese Can read, write, speak, understand spoken and peer review Spanish; Castilian Can read, write, speak and understand spoken -
Education
Date Institution name Country Title 2012 - 2016 Max Planck Institute for Evolutionary Anthropology Germany PhD in Evolutionary Genetics University of Porto Portugal MSc Forensic and Population Genetics -
Research Interests
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Journals
Year Citation 2024 Rohrlach, A. B., Rivollat, M., de-Miguel-Ibáñez, P., Moilanen, U., Liira, A. M., Teixeira, J. C., . . . Prüfer, K. (2024). Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA. Nature Communications, 15(1), 8 pages.
Europe PMC12024 MacRoberts, R. A., Liberato, M., Roca-Rada, X., Valente, M. J., Relvado, C., Fernandes, T. M., . . . Maurer, A. F. (2024). Shrouded in history: Unveiling the ways of life of an early Muslim population in Santarém, Portugal (8<sup>th</sup>– 10<sup>th</sup> century AD). PLoS ONE, 19(3 March), 44 pages.
2024 Singh, P., Teixeira, J. C., Bolch, C., & Armbrecht, L. (2024). Marine sedimentary ancient DNA from Antarctic diatoms. Palaeogeography, Palaeoclimatology, Palaeoecology, 640, 112090.
2023 Taufik, L., Teixeira, J. C., Llamas, B., Sudoyo, H., Tobler, R., & Purnomo, G. A. (2023). Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects. Genes, 13(12), 1-11.
2022 Collen, E. J., Johar, A. S., Teixeira, J. C., & Llamas, B. (2022). The immunogenetic impact of European colonization in the Americas. Frontiers in Genetics, 13, 918227-1-918227-12.
Scopus32022 Roca-Rada, X., Tereso, S., Rohrlach, A. B., Brito, A., Williams, M. P., Umbelino, C., . . . Teixeira, J. C. (2022). A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics.. Lancet (London, England), 400(10353), 691-692.
Scopus7 WoS1 Europe PMC32022 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., . . . Huber, C. D. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, 6(12), 2003-2015.
Scopus8 WoS3 Europe PMC122021 Teixeira, J. C., & Huber, C. D. (2021). The inflated significance of neutral genetic diversity in conservation genetics. Proceedings of the National Academy of Sciences, 118(10), e2015096118.
Scopus194 WoS158 Europe PMC902021 Aguiar Macedo Teixeira, J. C., Jacobs, G. S., Stringer, C., Tuke, S., Hudjashov, G., Purnomo, G. A., . . . Helgen, K. M. (2021). Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture. Nature Ecology & Evolution, 5(5), 616-624.
Scopus24 WoS18 Europe PMC122021 Roca-Rada, X., Politis, G., Messineo, P. G., Scheifler, N., Scabuzzo, C., Gonzalez, M., . . . Fehren-Schmitz, L. (2021). Ancient mitochondrial genomes from the Argentinian Pampas inform the early peopling of the Southern Cone of South America. iScience, 24(6), 1-18.
Scopus12 WoS12 Europe PMC22021 Purnomo, G. A., Mitchell, K. J., O'Connor, S., Kealy, S., Taufik, L., Schiller, S., . . . Tobler, R. (2021). Mitogenomes reveal two major influxes of Papuan ancestry across Wallacea following the last glacial maximum and Austronesian contact. Genes, 12(7), 1-21.
Scopus14 WoS12 Europe PMC72021 Teixeira, J. C., & Huber, C. D. (2021). Authors’ Reply to Letter to the Editor: Neutral genetic diversity as a useful tool for conservation biology. Conservation Genetics, 22(4), 547-549.
Scopus1 WoS12020 Williams, M., & Teixeira, J. (2020). A genetic perspective on human origins. Biochemist, 42(1), 6-10.
Scopus12020 O'Neill, M. B., Laval, G., Aguiar Macedo Teixeira, J., Palmenberg, A. C., & Pepperell, C. S. (2020). Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years. Human molecular genetics, 29(5), 736-744.
Scopus6 WoS5 Europe PMC52020 Barquera, R., Collen, E., Di, D., Buhler, S., Aguiar Macedo Teixeira, J., Llamas, B., . . . Sanchez-Mazas, A. (2020). Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide. HLA, 96(3), 277-298.
Scopus72 WoS57 Europe PMC582020 Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S., Schmidt, J., . . . Cooper, A. (2020). Ancient human genomes reveal a hidden history of strong selection in Eurasia.
2020 Roca-Rada, X., Souilmi, Y., Teixeira, J. C., & Llamas, B. (2020). Ancient DNA studies in pre-Columbian Mesoamerica. Genes, 11(11), 1-19.
Scopus5 WoS4 Europe PMC22019 Teixeira, J., & Cooper, A. (2019). A ‘Denisovan’ genetic history of recent human evolution.
2019 Teixeira, J. C., & Cooper, A. (2019). Using hominin introgression to trace modern human dispersals. Proceedings of the National Academy of Sciences, 116(31), 15327-15332.
Scopus22 WoS18 Europe PMC102018 Bitarello, B. D., de Filippo, C., Teixeira, J. C., Schmidt, J. M., Kleinert, P., Meyer, D., & Andrés, A. M. (2018). Signatures of Long-Term Balancing Selection in Human Genomes. Genome Biology and Evolution, 10(3), 939-955.
Scopus67 WoS67 Europe PMC512015 Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Reply to letter from Felice L. Bedford and Doron Yacobi. European Journal of Human Genetics, 23(8), 994-995.
2015 Nogueiro, I., Teixeira, J. C., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Portuguese crypto-Jews: the genetic heritage of a complex history. Frontiers in Genetics, 6(FEB), 1-12.
Scopus8 WoS9 Europe PMC42015 Teixeira, J. C., de Filippo, C., Weihmann, A., Meneu, J. R., Racimo, F., Dannemann, M., . . . Andrés, A. M. (2015). Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos. Molecular Biology and Evolution, 32(5), 1186-1196.
Scopus55 WoS53 Europe PMC432015 Nogueiro, I., Teixeira, J., Amorim, A., Gusmão, L., & Alvarez, L. (2015). Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants. European Journal of Human Genetics, 23(5), 693-699.
Scopus12 WoS14 Europe PMC52014 Key, F. M., Teixeira, J. C., de Filippo, C., & Andrés, A. M. (2014). Advantageous diversity maintained by balancing selection in humans. Current Opinion in Genetics & Development, 29, 45-51.
Scopus71 WoS74 Europe PMC522011 Teixeira, J. C., Nogueiro, I., Goios, A., Gusmão, L., Amorim, A., & Alvarez, L. (2011). Mitochondrial DNA-control region sequence variation in the NE Portuguese Jewish community. Forensic Science International: Genetics Supplement Series, 3(1), E51-E52.
Scopus5 WoS6 -
Conference Papers
Year Citation 2016 Andres, A. M., Dannemann, M., Teixeira, J., & Kelso, J. (2016). Balancing selection and adaptive introgression as sources of advantageous genetic diversity in populations. In AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY Vol. 159 (pp. 80-81). Atlanta, GA: WILEY-BLACKWELL. -
Conference Items
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 - 2022 Co-Supervisor Post-contact evolutionary immunogenetics in Indigenous peoples of America Doctor of Philosophy Doctorate Full Time Ms Evelyn Jane Collen 2019 - 2022 Co-Supervisor Human demographic insights from paleogenetic studies of American and Iberian skeletal remains Doctor of Philosophy Doctorate Full Time Mr Xavier Roca Rada 2018 - 2022 Co-Supervisor Reconstructing the Population History of Wallacea and Sahul Doctor of Philosophy Doctorate Full Time Dr Gludhug Ariyo Purnomo
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