Higher Degree by Research Candidate
School of Physical Sciences
Faculty of Sciences
Cytochromes P450 enzymes are a super-family of heme-thiolate– containing proteins or haem monooxygenases that can be found in almost all living organisms.P450 enzymes have significant roles in the synthesis of biosynthetic pathways for natural products, steroid hormones, drug metabolism and degradation of xenobiotics. My research aims in screening, engineering, and directed evolution of the catalytic activity of P450 enzymes in the synthesis of natural substrates.P450s peroxygenases can utilize H2O2 as a cheaper alternative to oxidize substrates into useful substances. Overall, my study will focus on investigating the cytochrome P450-catalyzed activity which is important in natural product synthesis.
Year Citation 2019 Ullah, S., Akter, J., Kim, S., Yang, J., Park, Y., Chun, P., & Moon, H. (2019). The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)-β-phenyl-α,β-unsaturated carbonyl scaffold of an endomethylene type. Medicinal Chemistry Research, 28(1), 95-103.
2019 Jo, J., Jeong, M., Ahn, J., Akter, J., Kim, H., Suh, Y., & Yun, H. (2019). Total synthesis of anmindenol A and its application to the design, synthesis, and biological evaluation of derivatives thereof. Journal of Organic Chemistry, 84(17), 10953-10961.
2019 Ullah, S., Park, Y., Park, C., Lee, S., Kang, D., Yang, J., . . . Moon, H. (2019). Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives. Bioorganic and Medicinal Chemistry, 27(11), 2192-2200.
DOI Scopus3 Europe PMC1
2019 Lee, S., Ullah, S., Park, C., Won Lee, H., Kang, D., Yang, J., . . . Moon, H. (2019). Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis. Bioorganic and Medicinal Chemistry, 27(17), 3929-3937.
2018 Kim, S., Yang, J., Lee, S., Park, C., Kang, D., Akter, J., . . . Moon, H. (2018). The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold. Bioorganic and Medicinal Chemistry, 26(14), 3882-3889.
DOI Scopus13 Europe PMC3
2018 Kim, M., An, H., Kim, D., Lee, B., Lee, H., Ullah, S., . . . Chung, H. (2018). Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. Bioorganic and Medicinal Chemistry Letters, 28(4), 684-688.
DOI Scopus8 Europe PMC2
2018 Ullah, S., Park, Y., Ikram, M., Lee, S., Park, C., Kang, D., . . . Moon, H. (2018). Design, synthesis and anti-melanogenic effect of cinnamamide derivatives. Bioorganic and Medicinal Chemistry, 26(21), 5672-5681.
DOI Scopus7 Europe PMC1
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