Higher Degree by Research Candidate
School of Physics, Chemistry and Earth Sciences
Faculty of Sciences, Engineering and Technology
Cytochromes P450 enzymes are a super-family of heme-thiolate– containing proteins or haem monooxygenases that can be found in almost all living organisms.P450 enzymes have significant roles in the synthesis of biosynthetic pathways for natural products, steroid hormones, drug metabolism and degradation of xenobiotics. My research aims in screening, engineering, and directed evolution of the catalytic activity of P450 enzymes in the synthesis of natural substrates.P450s peroxygenases can utilize H2O2 as a cheaper alternative to oxidize substrates into useful substances. Overall, my study will focus on investigating the cytochrome P450-catalyzed activity which is important in natural product synthesis.
Year Citation 2023 Akter, J., Stockdale, T. P., Child, S. A., Lee, J. H. Z., De Voss, J. J., & Bell, S. G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244, 112209-1-112209-9.
2019 Ullah, S., Park, Y., Park, C., Lee, S., Kang, D., Yang, J., . . . Moon, H. R. (2019). Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives. Bioorganic and Medicinal Chemistry, 27(11), 2192-2200.
DOI Scopus18 WoS18 Europe PMC11
2019 Lee, S., Ullah, S., Park, C., Won Lee, H., Kang, D., Yang, J., . . . Moon, H. R. (2019). Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis. Bioorganic and Medicinal Chemistry, 27(17), 3929-3937.
DOI Scopus18 WoS17 Europe PMC6
2019 Ullah, S., Akter, J., Kim, S. J., Yang, J., Park, Y., Chun, P., & Moon, H. R. (2019). The tyrosinase inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of
the (E) -b-phenyl-a, b-unsaturated carbonyl scaffold of an endomethylene type.. Medicinal Chemistry Research, 28(1), 95-103.
DOI Scopus9 WoS9
2019 Jo, J., Jeong, M., Ahn, J. S., Akter, J., Kim, H. S., Suh, Y. G., & Yun, H. (2019). Total synthesis of anmindenol A and its application to the design, synthesis, and biological evaluation of derivatives thereof. Journal of Organic Chemistry, 84(17), 10953-10961.
DOI Scopus7 WoS7
2018 Kim, S. J., Yang, J., Lee, S., Park, C., Kang, D., Akter, J., . . . Moon, H. R. (2018). The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-β-phenyl-α, β-unsaturated carbonyl scaffold. Bioorganic and Medicinal Chemistry, 26(14), 3882-3889.
DOI Scopus47 WoS45 Europe PMC14
2018 Kim, M. J., An, H. J., Kim, D. H., Lee, B., Lee, H. J., Ullah, S., . . . Chung, H. Y. (2018). Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. Bioorganic and Medicinal Chemistry Letters, 28(4), 684-688.
DOI Scopus17 WoS14 Europe PMC11
2018 Ullah, S., Park, Y., Ikram, M., Lee, S., Park, C., Kang, D., . . . Moon, H. R. (2018). Design, synthesis and anti-melanogenic effect of cinnamamide derivatives. Bioorganic and Medicinal Chemistry, 26(21), 5672-5681.
DOI Scopus28 WoS27 Europe PMC10
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