Jingxiu Bi

Associate Professor Jingxiu Bi

Associate Professor

School of Chemical Engineering and Advanced Materials

Faculty of Engineering, Computer and Mathematical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

I have more than 20 years experience in the research, teaching and pharmaceutical industrial consulting in the field of bioprocess design and optimization for biopharmaceutical product process development, both in fundamental and applied research. About 80 publications and 6 patents have been published. My current research main focus on:

1) Virus-like particles protein and modified protein as drug /vaccine carriers for cancer and disease treatment;
2) Biodegradable material development for gene/drug delivery
3) High through-put and scalable bioprocess development, integration and optimization;
4) Biomedical devices/biomaterials development for burn healing
5) Bioactive components screening and process development from traditional Chinese Medicines and formulation

I have more than 20 years experience in the research, teaching and industrial consultant in the field of bioprocess design and optimization for biopharmaceutical product process development, both in fundamental and applied research. About 80 publications and 6 patents have been published.  My current research main focus on:

1) Virus-like particles protein and modified protein as drug /vaccine carriers for  cancer and disease  treatment;
2) Biodegradable material development for gene/drug delivery 
3) High through-put and scalable bioprocess development, integration  and optimization;
4) Biomedical devices/biomaterials development for burn healing
5) Bioactive components screening and process development from traditional Chinese Medicines and formulation

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  • Appointments
    Date Position Institution name
    2014 - 2014 Visiting Professor Hamburg University of Technology, Hamburg
    2007 Associate Professor The University of Adelaide
    2004 - 2007 Associate Professor Institute of Process Engineering, Chinese Academy of Sciences
    2002 - 2004 Research Fellow University of Birmingham, Birmingham
    1999 - 2001 Postdoctoral Researcher Helmholtz Centre for Infection Research (HZ), Brunswick
    1993 - 1999 Research Assistant Institute of Process Engineering, Chinese Academy of Sciences

  • Language Competencies
    Language Competency
    Chinese (Mandarin) Can read, write, speak, understand spoken and peer review
    English Can read, write, speak, understand spoken and peer review

  • Education
    Date Institution name Country Title
    1996 - 1999 Institute of Process Engineering, Chinese Academy of Sciences China PhD of Chemical Engineering
    1990 - 1993 Institute of Process Engineering, Chinese Academy of Sciences China Master of Biochemical Engineering
    1986 - 1990 Beijing University of Technology and Commerce China Bachelor of Biochemical Engineering

  • Research Interests
    Biomaterials Biomedical Engineering Bioprocessing, Bioproduction and Bioproducts Biotechnology Gene and Molecular Therapy Nanobiotechnology Preventive Medicine
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  • Journals
    Year Citation
    2021 Gerstweiler, L., Billakanti, J., Bi, J., & Middelberg, A. (2021). Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies. Journal of Chromatography A, 1639, 1-11.
    DOI
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. (2021). Virus‐like particle preparation is improved by control over capsomere‐DNA interactions during chromatographic purification. Biotechnology and Bioengineering, 118(4), 1688-1701.
    DOI Scopus2 WoS3 Europe PMC1
    2021 de Prinse, T. J., Karami, A., Moffatt, J. E., Payten, T. B., Tsiminis, G., Teixeira, L. D. S., . . . Spooner, N. A. (2021). Dual Laser Study of Non-Degenerate Two Wavelength Upconversion Demonstrated in Sensitizer-Free NaYF4:Pr Nanoparticles. Advanced Optical Materials, 9(7), 1-7.
    DOI Scopus2 WoS2
    2021 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2021). Front Cover Image, Volume 118, Number 4, April 2021. Biotechnology and Bioengineering, 118(4).
    DOI
    2021 Qu, Y., Wang, L., Yin, S., Zhang, B., Jiao, Y., Sun, Y., . . . Bi, J. (2021). Stability of Engineered Ferritin Nanovaccines Investigated by Combined Molecular Simulation and Experiments. Journal of Physical Chemistry B, 125(15), 3830-3842.
    DOI Scopus1
    2021 Yin, S., Wang, Y., Zhang, B., Qu, Y., Liu, Y., Dai, S., . . . Bi, J. (2021). Engineered human heavy-chain ferritin with half-life extension and tumor targeting by PAS and RGDK peptide functionalization. Pharmaceutics, 13(4), 16 pages.
    DOI
    2021 Zhang, B., Yin, S., Wang, Y., Su, Z., & Bi, J. (2021). Cost-effective purification process development for chimeric hepatitis B core (HBc) virus-like particles assisted by molecular dynamic simulation. Engineering in Life Sciences, 21(6), 438-452.
    DOI
    2021 Yin, S., Davey, K., Dai, S., Liu, Y., & Bi, J. (2021). A critical review of ferritin as a drug nanocarrier: Structure, properties, comparative advantages and challenges. Particuology.
    DOI
    2021 Yin, S., Zhang, B., Lin, J., Liu, Y., Su, Z., & Bi, J. (2021). Development of purification process for dual-function recombinant human heavy-chain ferritin by the investigation of genetic modification impact on conformation. Engineering in Life Sciences, 13 pages.
    DOI
    2021 Qu, Y., Zhang, B., Wang, Y., Yin, S., Pederick, J. L., Bruning, J. B., . . . Bi, J. (2021). Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope. Vaccine, 39(34), 4830-4841.
    DOI Scopus1
    2021 Mellati, A., Kiamahalleh, M. V., Dai, S., Bi, J., Jin, B., & Zhang, H. (2021). Corrigendum to “Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide)” [Mater. Sci. Eng. C (2016) 509–513] (Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide) (2016) 59 (509–513), (S0928493115304744), (10.1016/j.msec.2015.10.043)). Materials Science and Engineering C, 129, 112368.
    DOI
    2021 Karami, A., Farivar, F., De Prinse, T. J., Rabiee, H., Kidd, S., Sumby, C. J., & Bi, J. (2021). Facile Multistep Synthesis of ZnO-Coated β-NaYF<inf>4</inf>:Yb/Tm Upconversion Nanoparticles as an Antimicrobial Photodynamic Therapy for Persistent Staphylococcus aureus Small Colony Variants. ACS Applied Bio Materials, 4(8), 6125-6136.
    DOI
    2021 Cui, X., Tang, J., Hartanto, Y., Zhang, J., Bi, J., Dai, S., . . . Zhang, H. (2021). Correction to "NIPAM-Based Microgel Microenvironment Regulates Cardiac Stem Cells".. ACS Appl Mater Interfaces, 13(35), 42307.
    DOI
    2021 Qu, Y., Zhang, B., Wang, Y., Yin, S., Sun, Y., Middelberg, A., & Bi, J. (2021). Immunogenicity and Vaccine Efficacy Boosted by Engineering Human Heavy Chain Ferritin and Chimeric Hepatitis B Virus Core Nanoparticles. ACS Applied Bio Materials, 4(9), 7147-7156.
    DOI
    2020 Zhang, Y., Yin, S., Zhang, B., Bi, J., Liu, Y., & Su, Z. (2020). HBc-based virus-like particle assembly from inclusion bodies using 2-methyl-2, 4-pentanediol. Process Biochemistry, 89, 233-237.
    DOI Scopus2 WoS2
    2020 Tung, T. T., Rastin, H., Zhang, B., Bi, J., Hassan, K., & Losic, D. (2020). 3D printing of cell-laden electroconductive bioink for tissue engineering application. Journal of Materials Chemistry B, 8(27), 5862-5976.
    DOI Scopus22 WoS21 Europe PMC11
    2020 Rastin, H., Zhang, B., Mazinani, A., Hassan, K., Bi, J., Tung, T. T., & Losic, D. (2020). 3D bioprinting of cell-laden electroconductive MXene nanocomposite bioinks. Nanoscale, 12(30), 16069-16080.
    DOI Scopus33 WoS31 Europe PMC11
    2020 Zhang, Y., Liu, Y., Zhang, B., Yin, S., Li, X., Zhao, D., . . . Su, Z. (2020). In vitro preparation of uniform and nucleic acid free hepatitis B core particles through an optimized disassembly-purification-reassembly process.. Protein Expr Purif, 178, 1-7.
    DOI Scopus2 WoS1 Europe PMC1
    2020 Gerstweiler, L., Bi, J., & Middelberg, A. P. J. (2020). Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies. Chemical Engineering Science, 231, 1-17.
    DOI Scopus3 WoS3
    2018 Guo, F., Liu, Y., Zhang, C., Wang, Q., Wang, L., Gao, Y., . . . Su, Z. (2018). Prompt and Robust Humoral Immunity Elicited by a Conjugated Chimeric Malaria Antigen with a Truncated Flagellin. Bioconjugate Chemistry, 29(3), 761-770.
    DOI Scopus7 WoS4 Europe PMC2
    2018 Cui, X., Tang, J., Hartanto, Y., Zhang, J., Bi, J., Dai, S., . . . Zhang, H. (2018). NIPAM-based microgel microenvironment regulates the therapeutic function of cardiac stromal cells. ACS Applied Materials and Interfaces, 10(44), 37783-37796.
    DOI Scopus15 WoS17 Europe PMC8
    2018 Cui, X., Hartanto, Y., Wu, C., Bi, J., Dai, S., & Zhang, H. (2018). Tuning microenvironment for multicellular spheroid formation in thermo-responsive anionic microgel scaffolds. Journal of Biomedical Materials Research - Part A, 106(11), 2899-2909.
    DOI Scopus8 WoS6 Europe PMC2
    2018 Zhu, H., Tian, L., Zhang, L., Bi, J., Song, Q., Yang, H., & Qiao, J. (2018). Preparation, characterization and antioxidant activity of polysaccharide from spent Lentinus edodes substrate. International Journal of Biological Macromolecules, 112, 976-984.
    DOI Scopus36 WoS31 Europe PMC3
    2018 Zhang, J., Yun, S., Bi, J., Dai, S., Du, Y., Zannettino, A., & Zhang, H. (2018). Enhanced multi-lineage differentiation of human mesenchymal stem/stromal cells within poly(N -isopropylacrylamide-acrylic acid) microgel-formed three-dimensional constructs. Journal of Materials Chemistry B, 6(12), 1799-1814.
    DOI Scopus8 WoS7 Europe PMC1
    2017 Mellati, A., Fan, C., Tamayol, A., Annabi, N., Dai, S., Bi, J., . . . Zhang, H. (2017). Microengineered 3D cell-laden thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering. Biotechnology and Bioengineering, 114(1), 217-231.
    DOI Scopus43 WoS41 Europe PMC10
    2017 Zhang, B., Zhang, H., Dai, S., & Bi, J. (2017). Cell-penetrating peptide-labelled smart polymers for enhanced gene delivery. Engineering in Life Sciences, 17(2), 193-203.
    DOI Scopus4 WoS4
    2017 Liu, L., Zhang, C., Li, Z., Wang, C., Bi, J., Yin, S., . . . Su, Z. (2017). Albumin binding domain fusing R/K-X-X-R/K sequence for enhancing tumor delivery of doxorubicin. Molecular Pharmaceutics, 14(11), 3739-3749.
    DOI Scopus5 WoS5 Europe PMC2
    2016 Cui, X., Liu, Y., Hartanto, Y., Bi, J., Dai, S., & Zhang, H. (2016). Multicellular spheroids formation and recovery in microfluidics-generated thermoresponsive microgel droplets. Colloid and Interface Science Communications, 14, 4-7.
    DOI Scopus13 WoS11
    2016 Mellati, A., Valizadeh Kiamahalleh, M., Dai, S., Bi, J., Jin, B., & Zhang, H. (2016). Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide). Materials Science and Engineering C, 59, 509-513.
    DOI Scopus17 WoS19 Europe PMC3
    2016 Xiong, L., Bi, J., Tang, Y., & Qiao, S. (2016). Magnetic core-shell silica nanoparticles with large radial mesopores for siRNA delivery. Small, 12(34), 4735-4742.
    DOI Scopus64 WoS64 Europe PMC24
    2016 Mellati, A., Kiamahalleh, M., Madani, S., Dai, S., Bi, J., Jin, B., & Zhang, H. (2016). Poly(N-isopropylacrylamide) hydrogel/chitosan scaffold hybrid for three-dimensional stem cell culture and cartilage tissue engineering. Journal of Biomedical Materials Research Part A, 104(11), 2764-2774.
    DOI Scopus32 WoS31 Europe PMC9
    2016 Cui, X., Dini, S., Dai, S., Bi, J., Binder, B., Green, J., & Zhang, H. (2016). A mechanistic study on tumour spheroids formation in thermosensitive hydrogels: experiments and mathematical modelling. RSC Advances, 6(77), 73282-73291.
    DOI Scopus22 WoS19
    2015 Yu, Y., Liang, W., Bi, J., Geng, Y., Kang, Z., & Zhao, Y. (2015). Thermophysical experiment and numerical simulation on thermal cracking of oil shale at high temperature. Yanshilixue Yu Gongcheng Xuebao/Chinese Journal of Rock Mechanics and Engineering, 34(6), 1106-1115.
    DOI Scopus6
    2015 Xiong, L., Du, X., Shi, B., Bi, J., Kleitz, F., & Qiao, S. (2015). Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery. Journal of Materials Chemistry B, 3(8), 1712-1721.
    DOI Scopus54 WoS53 Europe PMC1
    2015 Modra, K., Dai, S., Zhang, H., Shi, B., & Bi, J. (2015). Polycation-mediated gene delivery: challenges and considerations for the process of plasmid DNA transfection. Engineering in Life Sciences, 15(5), 489-498.
    DOI Scopus28 WoS27
    2015 Cui, X., Bi, J., Dai, S., & Ye, H. (2015). Single-cell analysis for bioprocessing. Engineering in Life Sciences, 15(6), 582-592.
    DOI Scopus2 WoS2
    2014 Mellati, A., Dai, S., Bi, J., Jin, B., & Zhang, H. (2014). A biodegradable thermosensitive hydrogel with tuneable properties for mimicking three-dimensional microenvironments of stem cells. RSC Advances, 4(109), 63951-63961.
    DOI Scopus35 WoS33
    2014 Shi, B., Zhang, H., Qiao, S., Bi, J., & Dai, S. (2014). Intracellular microenvironment-responsive label-free autofluorescent nanogels for traceable gene delivery. Advanced Healthcare Materials, 3(11), 1839-1848.
    DOI Scopus26 WoS28 Europe PMC10
    2014 Shen, Z., Mellati, A., Bi, J., Zhang, H., & Dai, S. (2014). A thermally responsive cationic nanogel-based platform for three-dimensional cell culture and recovery. RSC Advances, 4(55), 29146-29156.
    DOI Scopus18 WoS18
    2014 Shi, B., Zhang, H., Bi, J., & Dai, S. (2014). Endosomal pH responsive polymers for efficient cancer targeted gene therapy. Colloids and Surfaces B: Biointerfaces, 119, 55-65.
    DOI Scopus24 WoS23 Europe PMC7
    2014 Shi, B., Zhang, H., Dai, S., Du, X., Bi, J., & Qiao, S. (2014). Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery. Small, 10(5), 871-877.
    DOI Scopus20 WoS23 Europe PMC12
    2013 Elliott, P., Bi, J., & Zhang, H. (2013). Quality by design for biopharmaceuticals: a historical review and guide for implementation. Pharmaceutical Bioprocessing, 1(1), 105-122.
    DOI
    2013 Du, X., Shi, B., Liang, J., Bi, J., Dai, S., & Qiao, S. (2013). Developing functionalized dendrimer-like silica nanoparticles with hierarchical pores as advanced delivery nanocarriers. Advanced Materials, 25(41), 5981-5985.
    DOI Scopus163 WoS163 Europe PMC46
    2013 Geng, J., Bi, J., Zeng, A., & Yuan, J. (2013). Application of hybrid cybernetic model in simulating myeloma cell culture co-consuming glucose and glutamine with mixed consumption patterns. Process Biochemistry, 48(5-6), 955-964.
    DOI Scopus5 WoS4
    2013 Mijajlovic, M., Wright, D., Zivkovic, V., Bi, J., & Biggs, M. (2013). Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems. Colloids and Surfaces B-Biointerfaces, 104, 276-281.
    DOI Scopus38 WoS35 Europe PMC9
    2013 Shi, B., Zhang, H., Shen, Z., Bi, J., & Dai, S. (2013). Developing a chitosan supported imidazole Schiff-base for high-efficiency gene delivery. Polymer Chemistry, 4(3), 840-850.
    DOI Scopus38 WoS38
    2012 Shen, Z., Bi, J., Shi, B., Nguyen, D., Xian, C., Zhang, H., & Dai, S. (2012). Exploring thermal reversible hydrogels for stem cell expansion in three-dimensions. Soft Matter, 8(27), 7250-7257.
    DOI Scopus26 WoS24
    2012 Shi, B., Deng, L., Shi, X., Dai, S., Zhang, H., Wang, Y., . . . Guo, M. (2012). The enhancement of neural stem cell survival and growth by coculturing with expanded sertoli cells in vitro. Biotechnology Progress, 28(1), 196-205.
    DOI Scopus9 WoS10 Europe PMC5
    2012 Shen, Z., Shi, B., Zhang, H., Bi, J., & Dai, S. (2012). Exploring low-positively charged thermosensitive copolymers as gene delivery vectors. Soft Matter, 8(5), 1385-1394.
    DOI Scopus20 WoS22
    2012 Shi, B., Shen, Z., Zhang, H., Bi, J., & Dai, S. (2012). Exploring N-Imadozolyl-O-Carboxymethyl Chitosan for High Performance Gene Delivery. Biomacromolecules, 13(1), 146-153.
    DOI Scopus68 WoS63 Europe PMC23
    2011 Zhang, H., Dai, S., Bi, J., & Liu, K. (2011). Biomimetic three-dimensional microenvironment for controlling stem cell fate. Interface Focus, 1(5), 792-803.
    DOI Scopus48 WoS43 Europe PMC23
    2011 Shen, Z., Wei, W., Tanaka, H., Kohama, K., Ma, G., Dobashi, T., . . . Dai, S. (2011). A galactosamine-mediated drug delivery carrier for targeted liver cancer therapy. Pharmacological Research, 64(4), 410-419.
    DOI Scopus64 WoS64 Europe PMC23
    2011 Shen, Z., Li, Y., Kohama, K., O'Neill, B., & Bi, J. (2011). Improved drug targeting of cancer cells by utilizing actively targetable folic acid-conjugated albumin nanospheres. Pharmacological Research, 63(1), 51-58.
    DOI Scopus100 WoS91 Europe PMC35
    2010 Huang, Y., Bi, J., Zhao, L., Ma, G., & Su, Z. (2010). Regulation of protein multipoint adsorption on ion-exchange adsorbent and its application to the purification of macromolecules. Protein Expression and Purification, 74(2), 257-263.
    DOI Scopus22 WoS22 Europe PMC8
    2010 Zhang, Y., Luo, J., Bi, J., Wang, J., Sun, L., Liu, Y., . . . Su, Z. (2010). Efficient separation of homologous α-lactalbumin from transgenic bovine milk using optimized hydrophobic interaction chromatography. Journal of Chromatography A, 1217(23), 3668-3673.
    DOI Scopus14 WoS10 Europe PMC3
    2010 Shi, B., Zhang, S., Wang, Y., Zhuang, Y., Chu, J., Zhang, S., . . . Guo, M. (2010). Expansion of mouse sertoli cells on microcarriers. Cell Proliferation, 43(3), 275-286.
    DOI Scopus10 WoS9 Europe PMC7
    2009 Lu, Y., Wang, L., Xue, Y., Zhang, C., Xing, X. H., Lou, K., . . . Su, Z. (2009). Production of violet pigment by a newly isolated psychrotrophic bacterium from a glacier in Xinjiang, China. Biochemical Engineering Journal, 43(2), 135-141.
    DOI Scopus55 WoS47
    2008 Wu, T., Huang, Y., Bi, J., Zhang, Y., Sun, L., Sun, C., & Su, Z. (2008). Effect of solution environment on the purification of pertussis toxin. Chinese Journal of Biotechnology, 24(7), 1279-1284.
    DOI Scopus1
    2008 Liu, Y., Bi, J., Zeng, A., & Yuan, J. (2008). A cybernetic model to describe the dynamics of myeloma cell cultivations. Applied Mathematics and Computation, 205(1 Sp Iss), 84-97.
    DOI Scopus8 WoS6
    2008 Liu, Y., Bi, J., Zeng, A., & Yuan, J. (2008). A simple kinetic model for myeloma cell culture with consideration of lysine limitation. Bioprocess and Biosystems Engineering, 31(6), 569-577.
    DOI Scopus15 WoS14 Europe PMC5
    2008 Zhou, F., Bi, J., Zeng, A., & Yuan, J. (2008). Modeling of the cell cycle for myeloma cell culture. Shanghai Jiaotong Daxue Xuebao/Journal of Shanghai Jiaotong University, 42(7), 1207-1210.
    2007 Zhou, F., Bi, J., Zeng, A., & Yuan, J. (2007). A macrokinetic model for myeloma cell culture based on stoichiometric balance. Biotechnology and Applied Biochemistry, 46(2), 85-95.
    DOI Scopus5 WoS4 Europe PMC3
    2007 Li, Y., Bi, J., Zhou, W., Huang, Y., Sun, L., Zeng, A., . . . Su, Z. (2007). Characterization of the large size aggregation of Hepatitis B virus surface antigen (HBsAg) formed in ultrafiltration process. Process Biochemistry, 42(3), 315-319.
    DOI Scopus24 WoS21
    2007 Zhou, W., Bi, J., Zhao, L., Wang, Y., Li, Y., Huang, Y., . . . Su, Z. (2007). A highly efficient hydrophobic interaction chromatographic absorbentnext term improved the purification of hepatitis B surface antigen (HBsAg) derived from Hansenula polymorpha cell. Process Biochemistry, 42(5), 751-756.
    DOI Scopus15 WoS13
    2007 Yu, P., Zhang, G., Bi, J., Lu, X., Wang, Y., & Su, Z. (2007). Facile purification of mono-PEGylated interleukin-1 receptor antagonist and its characterization with multi-angle laser light scattering. Process Biochemistry, 42(6), 971-977.
    DOI Scopus11 WoS11
    2007 Zheng, C., Bi, J., Ma, G., & Su, Z. (2007). Polyethylene glycol improves conjugation of bovine hemoglobin and human serum albumin in a controlled ratio. Artificial Cells Blood Substitutes and Immobilization Biotechnology, 35(6), 568-584.
    DOI Scopus1 WoS1
    2007 Huang, Y., Bi, J., Zhang, Y., Zhou, W., Li, Y., Zhao, L., & Su, Z. (2007). A highly efficient integrated chromatographic procedure for the purification of recombinant hepatitis B surface antigen from Hansenula polymorpha. Protein Expression and Purification, 56(2), 301-310.
    DOI Scopus28 WoS23 Europe PMC8
    2007 Liu, Y., Bi, J., Zeng, A., & Yuan, J. (2007). A Population Balance Model Describing the Cell Cycle Dynamics of Myeloma Cell Cultivation. Biotechnology Progress, 23(5), 1198-1209.
    DOI Scopus24 WoS25 Europe PMC17
    2007 Li, R., Li, Y., Bi, J., Zhao, L., Zhou, W., Huang, Y., . . . Su, Z. (2007). Comparison of Adsorbent with Varying Spacer Arm Length and Ligand Density for the Purification of Recombinant Hepatitis B Virus Surface Antigen. Chinese Journal of Biotechnology, 23(4), 692-699.
    DOI
    2006 Zhou, F., Bi, J., Zeng, A., & Yuan, J. (2006). A macrokinetic and regulator model for myeloma cell culture based on metabolic balance of pathways. Process Biochemistry, 41(10), 2207-2217.
    DOI Scopus15 WoS12
    2006 Zhou, W., Bi, J., Janson, J., Li, Y., Huang, Y., Zhang, Y., & Su, Z. (2006). Molecular characterization of recombinant Hepatitis B surface antigen from Chinese hamster ovary and Hansenula polymorpha cells by high-performance size exclusion chromatography and multi-angle laser light scattering. Journal of Chromatography. B, Analytical Techniques in the Biomedical and Life Sciences, 838(2), 71-77.
    DOI Scopus37 WoS30 Europe PMC17
    2006 Huang, Y., Bi, J., Zhou, W., Wang, Y., Ma, G., & Su, Z. (2006). Improving recovery of recombinant hepatitis B virus surface antigen by ion-exchange chromatographic supports with low ligand density. Process Biochemistry, 41(11), 2320-2326.
    DOI Scopus30 WoS28
    2006 Zhang, Y., Bi, J. X., Zhou, W. B., Li, Y., Dong, A. H., Sun, J., & Su, Z. G. (2006). Purification of recombinant hepatitis B virus surface antigen with peg precipitation and chromatography. Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering, 6(1), 100-103.
    Scopus2
    2006 Wang, Y. M., Bi, J. X., Zhao, L., Zhou, W. B., Li, Y., Huang, Y. D., . . . Su, Z. G. (2006). Development of a new hydrophobic interaction chromatography absorbent and its application to the purification of recombinant hepatitis B surface antigen. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 22(2), 278-284.
    Scopus1
    2005 Zhang, F., Bi, J. X., Zeng, A. P., & Yuan, J. Q. (2005). Simple kinetic model for myeloma cell growth with lysine as a limiting substrate. Shanghai Jiaotong Daxue Xuebao/Journal of Shanghai Jiaotong University, 39(SUPPL.), 182-186.
    2005 Bi, J. X., Zhou, W. B., Li, Y., Huang, Y. D., Zhang, Y., Dong, A. H., & Su, Z. G. (2005). Polyethylene glycol-accompanied ion-exchange chromatography to purify recombinant hepatitis B virus surface antigen. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 21(6), 947-953.
    Scopus3
    2005 Chen, T., Yun, Q., Bi, J. X., Ma, G. H., & Su, Z. G. (2005). Separation and purification of PEGylated rhG-CSF by two-step ion-exchange chromatography. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 21(2), 284-288.
    2005 Yun, Q., Chen, T., Zhang, G., Bi, J., Ma, G., & Su, Z. (2005). Novel polyethylene glycol derivative suitable for the preparation of mono-PEGylated protein. Biotechnology Letters, 27(3), 213-217.
    DOI Scopus3 WoS2
    2005 Yun, Q., Yang, R., Chen, T., Bi, J., Ma, G., & Su, Z. (2005). Reproducible preparation and effective separation of PEGylated recombinant human granulocyte colony-stimulating factor with novel “PEG-pellet” PEGylation mode and ion-exchange chromatography. Journal of Biotechnology, 118(1), 67-74.
    DOI Scopus16 WoS16 Europe PMC9
    2005 Zhi, W., Song, J., Ouyang, F., & Bi, J. (2005). Application of response surface methodology to the modeling of α-amylase purification by aqueous two-phase systems. Journal of Biotechnology, 118(2), 157-165.
    DOI Scopus48 WoS44 Europe PMC17
    2005 Zhou, W., Bi, J., Janson, J., Dong, A., Li, Y., Zhang, Y., . . . Su, Z. (2005). Ion-exchange chromatography of hepatitis B virus surface antigen from a recombinant Chinese hamster ovary cell line. Journal of Chromatography A, 1095(1-2), 119-125.
    DOI Scopus29 WoS30 Europe PMC13
    2005 Li, X., Sun, H., Zhang, G., Bi, J., Ma, G., Ma, R., & Su, Z. (2005). A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales. Journal of Separation Science, 28(17), 2363-2369.
    DOI Scopus2 WoS1
    2004 Bi, J., Shuttleworth, J., & Al-Rubeai, M. (2004). Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells. Biotechnology and Bioengineering, 85(7), 741-749.
    DOI Scopus95 WoS95 Europe PMC65
    2004 Yun, Q., He, M., Xing, W., Bi, J., Ma, G., & Su, Z. (2004). A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin. Biotechnology Letters, 26(17), 1359-1363.
    DOI Scopus3 WoS3 Europe PMC1
    2004 Zhi, W., Song, J., Bi, J., & Ouyang, F. (2004). Partial purification of α-amylase from culture supernatant of Bacillus subtilis in aqueous two-phase systems. Bioprocess and Biosystems Engineering, 27(1), 3-7.
    DOI Scopus26 WoS24 Europe PMC8
    2003 Bi, J., Buhr, P., Zeng, A., & Wirth, M. (2003). Human c-fos promoter mediates high-level, inducible expression in various mammalian cell lines. Biotechnology and Bioengineering, 81(7), 848-854.
    DOI Scopus3 WoS4 Europe PMC2
    2003 Ibarra, N., Bi, J., Shuttleworth, J., Al-Rubeai, M., & Watanabe, S. (2003). Modulation of Cell Cycle for Enhancement of Antibody Productivity in Perfusion Culture of NS0 Cells. Biotechnology Progress, 19(1), 224-228.
    DOI WoS45 Europe PMC27
    2002 Bi, J., Wirth, M., Beer, C., Kim, E., Guc, M., & Zeng, A. (2002). Dynamic characterization of recombinant Chinese Hamster Ovary cells containing an inducible c-fos promoter GFP expression system as a biomarker. Journal of Biotechnology, 93(3), 231-242.
    DOI Scopus21 WoS19 Europe PMC9
    1996 Bi, J. X., Ouyang, F., Liu, D. H., Guo, Z. C., Gui, Y. L., & Yang, Y. G. (1996). Studies of technical conditions of somatic embryogenesis in cell suspension culture of Apium graveolens. Acta Botanica Sinica, 38(6), 451-456.

  • Conference Papers
    Year Citation
    2010 Shi, B., Guo, M., & Bi, J. (2010). Optimization of Expansion of Mouse Sertoli Cells on Microcarriers and Potential Application in Co-Culture with Nerve Stem Cells. In Proceedings of the Chemeca 2010 Conference Vol. 2010. Adelaide, Australia.

  • Conference Items
    Year Citation
    2013 Shi, B., Zhang, M., Bi, J., & Dai, S. (2013). Development of a novel folic acid chitosan supported imidazole Schiff base for tumor targeted gene delivery system and drug therapy. Poster session presented at the meeting of Conference abstracts of the Symposium on Innovative Polymers for Controlled Delivery, as published in Journal of Controlled Release. Suzhou, PEOPLES R CHINA: Elsevier.
    DOI WoS4
    2008 Bi, J., Huang, Y., Su, Z., King, K., & Middelberg, A. (2008). Mechanism and controlled purification of self-assembly virus like particles in bioprocess. Poster session presented at the meeting of Abstracts of the 13th International Biotechnology Symposium & Exhibition (IBS-2008): Biotechnology for Sustainability of Human Society, as published in Journal of Biotechnology. Dalian, China: Elsevier BV.
    DOI
    2008 Bi, J., Huang, Y., Su, Z., King, K., & Middelberg, A. (2008). Mechanism and controlled purification of self-assembly virus like particles in bioprocess. Poster session presented at the meeting of Abstracts of the 13th International Biotechnology Symposium & Exhibition (IBS-2008): Biotechnology for Sustainability of Human Society, as published in Journal of Biotechnology. Dalian, China: Elsevier BV.
    DOI
  • DVCR-Research Facility Fund--Biorpocess Facility Fund, AP Jingxiu Bi, $685,000, 2018
  • Contract Research (ARI, A135382), Characterization and evaluation of mussel adhesive protein (MAP) in vitro cell/tissue culture; Funded by Jiangyin Usun Technology Co. Ltd, Sole CI, $100,000. 2015-2017
  • DAAD-Gro8 Research Fund; Bio-system study for mammalian cell transient transfection, Sole CI, $10,000; 2014
  • Innovative Production Platform for Mussel Adhesive Protein (MAP), Prof. Christodoulos A. Floudas (University of Princeton, USA), Dr Jingxiu Bi, (The University of Adelaide), and Prof. Ming Gu, (Institute of Process Engineering, Chinese Academy of Sciences) supported by Department of Science and Technology of Jiangsu Province, China, RMB3,000,000 (Au$ 600,000), 2014-2016
  • AKTA System-High Throughput Protein Purification Platform; Dr Jingxiu Bi, DVCR Equipment Fund, $120,000; 2012
  • Detection of Virus like particles aggregation in downstream process, Faculty of EMCS Cat-1 Improvement Scheme, Sole CI, $15,000; 2011
  • Transient Production of Therapeutic Compounds, Prof. Wei Zhang, Prof. Chris Franco (Flinders Uni.), Dr Jingxiu Bi and Dr Hu Zhang (UniA), MLA (Meat Livestock Australia, Project Number: A.BIT.0017) Innovation Fund, $350,000; 2010
  • Prediction of Binding Capacity of VLPs on the Surface of Ionic Absorbents, Faculty of EMCS Cat-1 Improvement Scheme, Sole CI, $25,000; 2009
  • Innovative Hydrogen Bond Absorbents Development for Peptide Purification, Chinese Pharmaceutical Industrial Innovative Technology Fund, Prof. Ming Gu, and Dr Jingxiu Bi 2 years,  RMB 300,000 (AU $56,000); 2008
  •  Self-Assemble of Virus like particles induced by harsh chemical condition in downstream process,; The University of Adelaide, Faculty of ECMS new staff start-up, Sole CI, $10,000; 2007
  •  Recombinant Protein Purification from Transgenic Milk, Chinese “863” High-Tech. Research Grant, 2 years, Sole CI, RBM 1000,000 (around AU$178,000); 2007

COURSE TAUGHT (PAST 5 YEARS)

COURSE TITLE

YEAR LEVEL

YEAR TAUGHT

CLASS SIZE

DUTIES PERFORMED

Pharmaceutical Production Processes

II

2012-Now

25

New course, subject coordinator and sole lecturer

Introduction of Pharmaceutical Engineering

I

2012-2013

25

New Course, subject coordinator and sole lecturer

Pharmaceutical Project and Experiment Design

III

 2013-Now

25

New course, subject coordinator and sole lecturer

Chemical Engineering Experiment Design

III

2013-2014

82

Subject coordinator and co-lecturer

Introduction of Process Engineering

I

2013-2014

135

Co-lecturer

Principles of Biotechnology

II

2013-now

24

Subject coordinator and co-lecturer

Pharmaceutical Process Validation and Quality Control

IV

2014-Now

20

New course, subject Coordinator and sole lecturer

Pharmaceutical Plant Design Project

IV

2010-now

6

Co-Lecturer
    Expand

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2021 Principal Supervisor Fundamental study of chimeric protein molecular design and stability Doctor of Philosophy Doctorate Full Time Miss Hong Luo
    2021 Principal Supervisor Chimeric epitope-based protein as vaccine candidate-stability vs process Master of Philosophy Master Full Time Ms Yang Yang
    2019 Co-Supervisor Developing a continuous bioseparation process for a VLP-based Group A Streptococcus vaccine Doctor of Philosophy Doctorate Full Time Mr Lukas Gerstweiler
    2018 Principal Supervisor Ferritin as Protein Nanoparticle Delivery Platform - Molecular Dynamic and Experiment Simulation Doctor of Philosophy Doctorate Full Time Miss Yiran Qu
    2018 Principal Supervisor Development of novel antimicrobial nanomaterials for surface elimination of persistent bacteria Doctor of Philosophy Doctorate Full Time Mr Afshin Karami
    2017 Co-Supervisor Computational Study and Experiments of Nanoscale Metal-Organic Frameworks as Drug Carrier for Brain Diseases Doctor of Philosophy Doctorate Part Time Mr Yechuan Zhang
    2017 Co-Supervisor Developing a Nanocomposite Device for Rapid analysis of Bacteria Doctor of Philosophy Doctorate Full Time Ms Thai Thao Ly

  • Past Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 - 2021 Principal Supervisor A STATISTICAL METHODOLOGY TO OPTIMISE SOLUBLE PRODUCTION OF VIRUS-LIKE PARTICLE PROTEIN BY FERMENTATION OF ESCHERICHIA COLI Master of Philosophy Master Full Time Mr Nhat Hoang Huynh
    2016 - 2021 Principal Supervisor ENGINEERED HUMAN HEAVY-CHAIN FERRITIN TO IMPROVE ANTI-TUMOUR DRUG DELIVERY PERFORMANCE Doctor of Philosophy Doctorate Full Time Miss Shuang Yin
    2016 - 2021 Principal Supervisor Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses Doctor of Philosophy Doctorate Full Time Mr Bingyang Zhang
    2015 - 2019 Co-Supervisor Intracellular Microenvironment Triggered Co-delivery of Anticancer Drugs and Genes Doctor of Philosophy Doctorate Full Time Mr Seonho Yun
    2013 - 2015 Co-Supervisor Smart Drug Conjugated Silica Nanoparticles for Controlled and Sustained Release Master of Philosophy Master Full Time Ms Wanxia Zhao
    2013 - 2017 Co-Supervisor Mesoporous Silica Nanocomposites for Drug and Gene Delivery Doctor of Philosophy Doctorate Full Time Mr Lin Xiong
    2013 - 2015 Principal Supervisor Intracellular Microenvironment Responsive Nanogels for Gene Delivery Master of Philosophy Master Full Time Mr Bingyang Zhang
    2013 - 2017 Co-Supervisor Thermoresponsive Microgels for Multicellular Spheroids Formation Doctor of Philosophy Doctorate Full Time Mr Xiaolin Cui
    2013 - 2016 Principal Supervisor Microfluidic System Development for Drug Delivery Master of Engineering Science Master Full Time Mengjue Zhang
    2013 - 2016 Principal Supervisor Mechanism of Bevacinzumab Adsorption with Affinity Ligands and Bioprocess Optimization for Antibody Purification Master of Engineering Science Master Full Time Yuzhe Tang
    2011 - 2015 Principal Supervisor Quality by Design for the Downstream Processing of Biopharmaceuticals Doctor of Philosophy Doctorate Full Time Mr Phillip Wayne Elliott
    2010 - 2014 Principal Supervisor Enhancement of Gene Therapy by Exploring Functional Gene Vectors Based on Chitosan Modification. Doctor of Philosophy Doctorate Full Time Mr Bingyang Shi
    2009 - 2015 Co-Supervisor Molecular Dynamics Study of Peptide Adsorption at Liquid/Solid Interfaces Doctor of Philosophy Doctorate Full Time Mr Matthew John Penna
  • Position: Associate Professor
  • Phone: 83134118
  • Email: jingxiu.bi@adelaide.edu.au
  • Campus: North Terrace
  • Building: Engineering North
  • Room: 108
  • Org Unit: School of Chemical Engineering and Advanced Materials
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