Senior Research Fellow and Senior Lecturer
School of Physical Sciences
Faculty of Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Jingxian Yu completed his BEng (Applied Chemistry) and MSc (Physical Chemistry) degrees in China, and PhD (nanoscience & nanotechnology) in Australia. Upon the completion of his PhD program he moved to the University of Cambridge, UK as a Roger Pysden Research Fellow and later the University of Nottingham, UK as a postdoctoral research fellow. He returned to Australia in 2009 to take up an ARC Australian Postdoctoral Fellowship (APD Fellow) at the University of Adelaide. Currently, he is a Senior Research Fellow & Senior Lecturer at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) headed by the University of Adelaide. He has a specific interest in electron transfer in peptides using combined electrochemical and computational techniques, and a growing interest in biological applications of nanomaterials. He is a recipient of a number of awards, including the CASS Foundation Award, Roger Pysden Memorial Fellowship, Ian Potter Foundation Award, Flinders University Overseas Travelling Fellowship and AMY Forwood Travelling Award.
Bio-inspired molecular electronics
Electron transfer in proteins can occur over long molecular distances to facilitate a number of crucial biological processes, including respiration and photosynthesis. A fundamental understanding of electron transfer in proteins is not only central to the elucidation of these essential biological processes in living organisms, but also to the design and development of bio-inspired molecular electronic components. Much research has been conducted on charge transfer in proteins, including azurin and the mitochondrial electron carrier, cytochrome C. However, in light of the complexity of such systems, synthetic model peptides present as excellent alternatives. Such peptides can adopt specific secondary structures, for instance helices and β-strands through diligent design, to allow the study of electron transfer in a somewhat more controlled setting. Furthermore, specific functionalization of their backbone enables precision-branching, a key feature of three-dimensional molecular circuitry. While molecular electronics provides an opportunity to begin to redefine integrated circuit technologies, one must first understand and subsequently be able to predict and control the associated charge transfer kinetics and dynamics before this vision can be realized.
To address these questions, we use a combination of theory and experiment to advance a fundamental understanding of electron transport in naturally occurring peptides, while exploiting their electronic properties to promote the design and development of functional bio-inspired molecular electronic devices. A bottom-up approach for the fabrication of components for the electronics industry will be required in the not too distant future, with the combination of solid-state techniques used here closely aligning to future device development.
Biological applications of nanomaterials
A case study: Photoswitchable Peptide-Modified Nanoporous Anodic Alumina for On-Demand Molecular Transport
The controlled transport of molecules across membranes is central to nature (e.g., in protein channels and ion pumps) but also to many highly valuable applications such as desalination, on-demand drug delivery, chromatography, and others. Artificial nanoporous membranes, for example nanoporous anodic alumina membranes (NAAMs), provide an important tool for studying the mechanisms and dynamics associated with molecular transporting across a membrane.
Here, an alternative approach to overcome the inherent limitations of polymer-based stimuli-responsive membranes, while providing the practical and functional requirements for selective on-demand molecular transport applications, are synthetic nanoporous membranes modified with optically switchable molecules (PSP-NAAMs). The results showed that the molecular transport across PSP-NAAMs could be repeatedly switched between on and off state, which is highly significant for on-demand triggered drug release systems.
Date Position Institution name 2019 Senior Research Fellow & Senior Lecturer The University of Adelaide 2017 - 2018 Senior Research Associate & Lecturer The University of Adelaide 2012 - 2016 ARC Research Associate The Unversity of Adelaide 2009 - 2012 ARC / Australian Postdoctoral Fellow (APD) The University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2013 Award CASS Foundation Travel Award — — — 2011 Award Ian Potter Foundation Travel Award — — — 2009 Research Award Australian Postdoctoral Fellowship (APD) ARC Australia —
Language Competency Chinese (Mandarin) Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2009 Flinders University, Adelaide Australia Doctor of Philosophy (Nanotechnology)
Research InterestsElectrochemistry Energy Generation, Conversion and Storage Engineering Molecular and Organic Electronics Nanofabrication, Growth and Self Assembly Nanoscale Characterisation Nanoscience & Nanotechnology Physical Chemistry Physical Organic Chemistry Proteins and Peptides Quantum Chemistry Theoretical and Computational Chemistry
|Funding Body||Funding Scheme||Project||Amount||Date||Investigators|
|ARC||Discovery Project||Bio-inspired molecular electronics: from nanoscience to nanotechnology||$ 416,584||2018-2020||Andrew D Abell, Jingxian Yu, Wenjing Hong and David Cahen.|
|IPAS||IPAS Pilot Project Funding Scheme||Double remote electrochemical addressing and optical readout of electrochemiluminescence at the nano-patterned tip of an optical fiber for the detection of peroxide explosives.||$6,000||2017||Jingxian Yu and Peipei Jia.|
|CAN||CAN Pilot Project Funding Scheme||Photoregulated Gating Enabled Smart Nanoconfined Structures||$8,000||2012-2013||Jingxian Yu, Mahaveer D Kurkuri, Andrew D Abell, Dusan Losic.|
|IPAS||IPAS Pilot Project Funding Scheme||
Photoswitchable β-Hairpin Peptides for Molecular Bio-optoelectronic Devices
|$7,000||2012||Jingxian Yu, Yinlan Ruan, Sabrina Heng, David Huang, Denis Scanlon and Andrew Abell.|
|ARC||Linkage Infrastructure, Equipment and Facilities Scheme||Ultraviolet, visible and infrared spectroscopic ellipsometers for advanced materials and device characterization||$300,000||2011||Heike Ebendorff-Heidepriem, Tanya M Monro, Andrew D Abell, David G Lancaster, Jingxian Yu and Hans J Griesser.|
|ARC||Discovery Project, incorporated with an award of Australian Postdoctoral Fellowship||Electron Transfer in Proteins, A Study of Mechanism and Function||$ 350,000||2009-2011||Andrew D Abell and Jingxian Yu (APD).|
National Supercomputing Time Grants
|Funding Body||Funding Scheme||Project||Amount||Date||Investigators|
|NCMAS||National Computational Merit Allocation Scheme||Peptronics: Understanding the Relationship between Structures and Properties||530kSU||2018||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Peptronics: Understanding the Relationship between Structures and Properties||100kSU||2017||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Peptronics: Understanding the Relationship between Structures and Properties||200kSU||2016||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Peptronics: Understanding the Relationship between Structures and Properties||250kSU||2015||Jingxian Yu|
National Computational Merit Allocation Scheme
Early Career Researcher Award
|Electron Transfer in Peptides, Structure and Function||250kSU||2014||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Electron Transfer in Peptides, Structure and Function||300kSU||2013||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Electron Transfer in Peptides, A study of Mechanism and Dynamics||450kSU||2012||Jingxian Yu|
|NCMAS||National Computational Merit Allocation Scheme||Electron Transfer in Peptides, Mechanism and Structure||200kSU||2011||Jingxian Yu|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor Synthesis and biological evaluation of natural mimetics Master of Philosophy Master Full Time Miss Theresa Chav 2017 Co-Supervisor Design, Synthesis and the Application of an Antimicrobial Peptide Doctor of Philosophy Doctorate Full Time Miss Yuan Qi Yeoh 2017 Co-Supervisor Enzyme-based therapeutics Master of Philosophy Master Full Time Mr Padraig Lorcan Fyfe
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2011 - 2015 Co-Supervisor The Effects of Macrocyclic Constraints on Electron Transfer in Peptides Doctor of Philosophy Doctorate Full Time Dr John Robert Horsley
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