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Dr Jiawen Li

Jiawen Li
Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr. Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. Her research interests include optical coherence tomography (OCT), imaging+sensing fibre-optic probes, Doppler OCT, multimodality imaging and ultra-thin endoscopes.

Her PhD research focused on the development of highly novel multimodal miniaturized fibre-optic imaging probes, where they fully integrated two or more complementary imaging modalities in one single unit.
After the completion of her PhD, She joined University of Western Australian (UWA) to lead the development of a flexible fibre-optic needle probe. Extended from this project, she proposed an innovative fibre-optic probe design that can provide co-localized imaging and aspiration. This was the cornerstone idea of an awarded grant (as the lead CI) and a journal publication (as the first and corresponding author, which also won IPAS Best ECR Paper Award).
In April 2016, she moved with her supervisor, Prof Robert McLaughlin, to University of Adelaide (UoA) to establish their new lab. They conducted a successful pilot clinical trial of our smart brain needle probes in 11 patients undergoing neurosurgery in late 2016. The tiny probe lets surgeons 'see' at-risk blood vessels as they insert the biopsy needle, allowing them to avoid causing potentially fatal bleeds. The results have been highlighted by ‘making a difference: outcomes of ARC supported research’.
Since 2017, she began to establish her own independent research area by actively applying for grants and delivering them. 1) As the lead CI of an awarded pilot project grant, she was able to investigate and demonstrate the first single-fibre based fibre-optic probe that can conduct imaging and temperature sensing simultaneously. 2) Strategically using the funding of her women’s research excellence award, she developed my unique expertise of 3D printing freeform micro-optics for fibre-optic probes (first-author journal paper under in-depth review by Scientific Reports) and strengthened her collaborative work on developing biocompatible fibre coatings. 3) Combining her unique expertise in fibre-optic probes and experience in research translation, she partner with Miniprobes Pty Ltd, a high-tech Australian start-up company, to translate our research outcomes to products suitable for industrial applications. She was recently awarded South Australian Government funding ‘Photonics Catalyst Program’, to support a University-Industry translational research project to develop fibre-optic imaging probes for the non-destructive testing market.

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Dr Jiawen Li

Dr. Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. Her research interests include optical coherence tomography (OCT), imaging+sensing fibre-optic probes, Doppler OCT, multimodality imaging and ultra-thin endoscopes.

Her PhD research focused on the development of highly novel multimodal miniaturized fibre-optic imaging probes, where they fully integrated two or more complementary imaging modalities in one single unit.
After the completion of her PhD, She joined University of Western Australian (UWA) to lead the development of a flexible fibre-optic needle probe. Extended from this project, she proposed an innovative fibre-optic probe design that can provide co-localized imaging and aspiration. This was the cornerstone idea of an awarded grant (as the lead CI) and a journal publication (as the first and corresponding author, which also won IPAS Best ECR Paper Award).
In April 2016, she moved with her supervisor, Prof Robert McLaughlin, to University of Adelaide (UoA) to establish their new lab. They conducted a successful pilot clinical trial of our smart brain needle probes in 11 patients undergoing neurosurgery in late 2016. The tiny probe lets surgeons 'see' at-risk blood vessels as they insert the biopsy needle, allowing them to avoid causing potentially fatal bleeds. The results have been highlighted by ‘making a difference: outcomes of ARC supported research’.
Since 2017, she began to establish her own independent research area by actively applying for grants and delivering them. 1) As the lead CI of an awarded pilot project grant, she was able to investigate and demonstrate the first single-fibre based fibre-optic probe that can conduct imaging and temperature sensing simultaneously. 2) Strategically using the funding of her women’s research excellence award, she developed my unique expertise of 3D printing freeform micro-optics for fibre-optic probes (first-author journal paper under in-depth review by Scientific Reports) and strengthened her collaborative work on developing biocompatible fibre coatings. 3) Combining her unique expertise in fibre-optic probes and experience in research translation, she partner with Miniprobes Pty Ltd, a high-tech Australian start-up company, to translate our research outcomes to products suitable for industrial applications. She was recently awarded South Australian Government funding ‘Photonics Catalyst Program’, to support a University-Industry translational research project to develop fibre-optic imaging probes for the non-destructive testing market.

Eligible to supervise Masters and PhD (as Co-Supervisor) — email supervisor to discuss availability.

High-resolution optical imaging technologies have rapidly gained importance, and a range of antibody-specific fluorescent biomarkers have driven new insights in disease mechanisms. However, optical techniques degrade rapidly in solid tissue due to absorption and multiple scattering of the photons, limiting their imaging depth and largely restricting their use to cell culture. To overcome this limit, we have been developing a series of multi-modal minimally-invasive imaging probes.

We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single-fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches
We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches.

https://phys.org/news/2018-04-tiny-probe-body-temperatures.html 

http://freshscience.org.au/state/sa/tiny-probe

https://www.nibib.nih.gov/news-events/newsroom/two-imaging-catheters-unite-better-detect-dangerous-plaques-arteries

http://www.octnews.org/articles/5026989/feature-of-the-week-11-24-13-miniature-oct-ivus-pr/

https://www.youtube.com/watch?v=Ag13_fxoARA

Appointments

Date Position Institution name
2016 Postdoctoral Researcher-Lecturer (research-only) University of Adelaide
2015 - 2016 Research Fellow University of Western Australia
2014 - 2014 R&D intern St. Jude Medical (United States)

Awards and Achievements

Date Type Title Institution Name Country Amount
2018 Research Award IPAS Best Early Career Researcher (ECR) Paper Award Institute for Photonics and Advanced Sensing Australia
2017 Research Award Women's Research Excellence Award The University of Adelaide $5000
2016 Research Award Research Travel award Adelaide Medical School Australia $3000
2016 Award Best poster award The International Conference on Information Optics and Photonics China
2015 Award Robert Newcomb Interdisciplinary Team Science Award University of California, Irvine United States
2015 Award Best technical poster Optics in Cardiology conference Netherlands $1100
2015 Fellowship Public Impact Fellow UC Irvine United States $650
2013 Award Community Award University of California, Irvine United States
2012 Honour Student Spotlight Report University of California, Irvine United States
2012 Achievement 3rd Place in Business Plan Competition, Life Science Division University of California, Irvine United States $3250
2011 Fellowship Graduate Growth Incentive Awards Fellowship University of California, Irvine United States ~$60000

Education

Date Institution name Country Title
2012 - 2015 University of California, Irvine USA PhD
2010 - 2012 University of California, Irvine USA Master
2006 - 2010 Zhejiang University China Bachelor of science

Research Interests

Journals

Year Citation
2018 Li, J., & E. Schartner, S. Musolino, B. Quirk, R. Kirk, H. Ebendorff-Heidepriem, R. McLaughlin. (2018). Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue. Optics Letters, 43(8), 1682-1685.
DOI
2017 Naqvi, A., Khedraki, R., Li, J., Chou, L. -D., Ramalingam, T., & Patel, P. (2017). HYBRID IVUS/OCT: “PROBING” THE FUTURE. Journal of the American College of Cardiology, 69(11), 976.
DOI
2017 Li, J., Quirk, B., Noble, P., Kirk, R., Sampson, D., & McLaughlin, R. (2017). Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration. Journal of Biomedical Optics, 22(10), 106002-1-106002-5.
DOI
2016 Li, J. (2016). 基于光学系统的血管内高集成多模态成像技术. 中国激光, 43(12), 1-13.
2016 Li, J., & Chen, Z. (2016). Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]. Journal of Biomedical Photonics & Engineering, 1(4), 209-224.
DOI
2015 Li, J., Minami, H., Steward, E., Ma, T., Mohar, D., Robertson, C., . . . Chen, Z. (2015). Optimal flushing agents for integrated optical and acoustic imaging systems. Journal of Biomedical Optics, 20(5), 056005.
DOI
2015 Li, J. (2015). Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo. Scientific Reports, 5(1), 1-7.
DOI
2015 Piao, Z., Ma, T., Li, J., Wiedmann, M., Huang, S., Yu, M., . . . Chen, Z. (2015). High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm. Applied Physics Letters, 107(8), 1-4.
DOI
2015 Ma, T., Yu, M., Chen, Z., Fei, C., Shung, K., & Zhou, Q. (2015). Multi-Frequency Intravascular Ultrasound (IVUS) Imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 62(1), 97-107.
DOI
2015 Ma, T., Yu, M., Li, J., Munding, C., Chen, Z., Fei, C., . . . Zhou, Q. (2015). Erratum: Multi-frequency intravascular ultrasound (IVUS) imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 62(3), 604.
DOI
2014 Liang, S., Ma, T., Jing, J., Li, X., Li, J., Kirk Shung, K., . . . Chen, Z. (2014). Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging. Optics Letters, 39(23), 1-10.
2014 Li, J., Ma, T., Mohar, D., Correa, A., zhou, Q., Patel, P. M., & Chen, Z. (2014). TCT-380 Integrated intravascular ultrasound (IVUS) optical coherence tomography (OCT) system for identifying thin-cap fibroatheroma. Journal of the American College of Cardiology, 64(11), B111.
DOI
2014 Li, J., Ma, T., Mohar, D., Correa, A., zhou, Q., Chen, Z., & Patel, P. M. (2014). TCT-369 Human coronary plaque characterization using a fully integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system. Journal of the American College of Cardiology, 64(11), B108.
DOI
2014 Xiang Li., Jiawen Li., Jing, J., Teng Ma., Shanshan Liang., Jun Zhang., . . . Zhongping Chen. (2014). Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization. IEEE Journal of Selected Topics in Quantum Electronics, 20(2), 196-203.
DOI
2014 Li, J., Li, X., Mohar, D., Raney, A., Jing, J., Zhang, J., . . . Chen, Z. (2014). Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis. JACC: Cardiovascular Imaging, 7(1), 101-103.
DOI
2013 Li, J., Ma, T., Jing, J., Zhang, J., Patel, P. M., Kirk Shung, K., . . . Chen, Z. (2013). Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display. Journal of Biomedical Optics, 18(10), 100502.
DOI
2013 Qi, W., Li, R., Ma, T., Li, J., Kirk Shung, K., Zhou, Q., & Chen, Z. (2013). Resonant acoustic radiation force optical coherence elastography. Applied Physics Letters, 103(10), 103704-1-103704-5.
DOI Europe PMC19
2012 Liang, S., Saidi, A., Jing, J., Liu, G., Li, J., Zhang, J., . . . Chen, Z. (2012). Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner. Journal of Biomedical Optics, 17(7), 070501-1-070501-3.
DOI
2011 Yin, J., Li, X., Jing, J., Li, J., Mukai, D., Mahon, S., . . . Chen, Z. (2011). Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging. Journal of Biomedical Optics, 16(6), 060505-1-060505-3.
DOI
2010 Meng, J., Ding, Z., Li, J., Wang, K., & Wu, T. (2010). Transit-time analysis based on delay-encoded beam shape for velocity vector quantification by spectral-domain Doppler optical coherence tomography.. Optics express, 18(2), 1261-1270.
DOI Europe PMC4

1. 2018 – South Australia Photonics Catalyst Program grant

Funding amount $45,000; J. Li is the lead CI of the proposal.

2. 2017 - Faculty of Health and Medical Sciences Research Infrastructure Funding Awards

Funding amount $20,000; J. Li is the second CI of this proposal.

3. 2017 - Pilot Project Grant, Institute of Photonics and Advance Sensing (IPAS)

Funding amount $8,000; J. Li is the lead CI of this proposal.

4. 2015 - Travel award, UoA

Award amount $3,000; J. Li is the only CI of this grant.

5. 2015 - Healy Research Collaboration award, Raine Medical research foundation

Funding amount $10,000; J. Li is the lead CI of this proposal. This is a grant to support early career researcher to independently lead translational research.

  Institute Year Topic
Guest Lecturer Polytechnique Montreal 2017 Optical coherence tomography
Guest Lecturer University of Southern California 2013 Optical coherence tomography

 

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Co-Supervisor Fiber Imaging Doctor of Philosophy Doctorate Full Time Ms Lu Peng

Other Supervision Activities

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2018 - ongoing Co-Supervisor High resolution microstructured optical fiber sensor The University of Adelaide Doctorate Lu Peng

Committee Memberships

Date Role Committee Institution Country
2018 - ongoing Member Technical Program Committee of the AIP Congress with AOS Conference and ACOFT
2017 - ongoing Member IPAS Science Management Committee
2017 - ongoing Chair IPAS Science Network Committee
Position
Lecturer
Phone
83138187
Campus
North Terrace
Building
Helen Mayo North Building
Org Unit
Adelaide Medical School

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