Jiawen Li

Dr Jiawen Li

Lecturer

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr. Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. Her research interests include optical coherence tomography (OCT), imaging+sensing fibre-optic probes, Doppler OCT, multimodality imaging and ultra-thin endoscopes.

In April 2016, she moved with her supervisor, Prof Robert McLaughlin, to University of Adelaide (UoA) to establish their new lab. They conducted a successful pilot clinical trial of our smart brain needle probes in 11 patients undergoing neurosurgery in late 2016. The tiny probe lets surgeons 'see' at-risk blood vessels as they insert the biopsy needle, allowing them to avoid causing potentially fatal bleeds. The results have been highlighted by ‘making a difference: outcomes of ARC supported research’ and are published on Science Advances.

Since 2017, she began to establish her own independent research area by actively applying for grants and delivering them. 1) As the lead CI of an awarded pilot project grant, she was able to investigate and demonstrate the first single-fibre based fibre-optic probe that can conduct imaging and temperature sensing simultaneously. 2) Strategically using the funding of her women’s research excellence award, she developed my unique expertise of 3D printing freeform micro-optics for fibre-optic probes (first-author journal publication on Scientific Reports) and strengthened her collaborative work on developing biocompatible fibre coatings. 3) Combining her unique expertise in fibre-optic probes and experience in research translation, she partner with Miniprobes Pty Ltd, a high-tech Australian start-up company, to translate our research outcomes to products suitable for industrial applications. She was recently awarded South Australian Government funding ‘Photonics Catalyst Program’, to support a University-Industry translational research project to develop fibre-optic imaging probes for the non-destructive testing market.

Funded mainly by National Heart Foundation and UoA, she has started to work as an independent researcher since Jan. 2019. The focus of her project is to develop miniaturised fibre probes by two-photon polymerisation 3D printing technology. She is developing ultrathin, flexible, multimodal fibre-optic imaging probes that will enable cross-sectional visualisation of vascular arteries with high resolution, molecular contrast, and sensitivity that are not possible with any other existing technologies. This cutting-edge tool will underpin biological studies to help answer fundamental questions at cellular level of how plaques evolve, how they cause heart attacks, and how they respond to different treatment.

High-resolution optical imaging technologies have rapidly gained importance, and a range of antibody-specific fluorescent biomarkers have driven new insights in disease mechanisms. However, optical techniques degrade rapidly in solid tissue due to absorption and multiple scattering of the photons, limiting their imaging depth and largely restricting their use to cell culture. To overcome this limit, we have been developing a series of multi-modal minimally-invasive imaging probes.

We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single-fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches
We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches.

http://freshscience.org.au/state/sa/tiny-probe

https://www.nibib.nih.gov/news-events/newsroom/two-imaging-catheters-unite-better-detect-dangerous-plaques-arteries

http://www.octnews.org/articles/5026989/feature-of-the-week-11-24-13-miniature-oct-ivus-pr/

https://www.youtube.com/watch?v=Ag13_fxoARA

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  • Appointments
    Date Position Institution name
    2019 Externally-Funded Research Fellow University of Adelaide
    2016 - 2018 Lecturer University of Adelaide
    2015 - 2016 Research Fellow University of Western Australia
    2014 - 2014 R&D intern St. Jude Medical (United States)

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2018 Research Award Executive Dean's Research Excellence Award (Early Career) The University of Adelaide Australia —
    2018 Research Award Faculty of Health and Medical Sciences Travel Award Faculty of Health and Medical Sciences Australia $2800
    2018 Research Award IPAS Best Early Career Researcher (ECR) Paper Award Institute for Photonics and Advanced Sensing Australia —
    2018 Award ‘Women in Photonics’ Workshop Travel Award Leibniz-IPHT Germany €800
    2017 Honour Fresh Science SA Finalist Fresh Science Australia —
    2017 Research Award Women's Research Excellence Award The University of Adelaide — $5000
    2016 Research Award Research Travel award Adelaide Medical School Australia $3000
    2016 Research Award Best poster award The International Conference on Information Optics and Photonics China —
    2015 Research Award Robert Newcomb Interdisciplinary Team Science Award University of California, Irvine United States —
    2015 Research Award Best technical poster Optics in Cardiology conference Netherlands €750
    2015 Honour Public Impact Fellow UC Irvine United States $650
    2013 Award Community Award University of California, Irvine United States —
    2012 Honour Student Spotlight Report University of California, Irvine United States —
    2012 Achievement 3rd Place in Business Plan Competition, Life Science Division University of California, Irvine United States $3250
    2011 Fellowship Graduate Growth Incentive Awards Fellowship University of California, Irvine United States ~$60000

  • Education
    Date Institution name Country Title
    2012 - 2015 University of California, Irvine USA PhD
    2010 - 2012 University of California, Irvine USA Master
    2006 - 2010 Zhejiang University China Bachelor of science

  • Research Interests
    Biomedical Engineering Nuclear Medicine & Medical Imaging Optical Technology Photonics and Electro-Optical Engineering
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  • Journals
    Year Citation
    2018 Li, J., Ebendorff-Heidepriem, H., Gibson, B., Greentree, A. D., Hutchinson, M., Jia, P., . . . Goldys, E. M. (2018). Perspective: biomedical sensing and imaging with optical fibers - innovation through convergence of science disciplines. APL Photonics, 3(10), 1-20.
    DOI Scopus2 WoS1
    2018 Li, J., Fejes, P., Lorenser, D., Quirk, B., Noble, P., Kirk, R., . . . McLaughlin, R. (2018). Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes. Scientific Reports, 8(1), 1-9.
    DOI
    2018 Ramakonar, H., Quirk, B., Kirk, R., Li, J., Jacques, A., Lind, C., & McLaughlin, R. (2018). Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans. Science Advances, 4(12), eaav4992-1-eaav4992-10.
    DOI Scopus1 WoS1
    2018 Li, J., & E. Schartner, S. Musolino, B. Quirk, R. Kirk, H. Ebendorff-Heidepriem, R. McLaughlin. (2018). Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue. Optics Letters, 43(8), 1682-1685.
    DOI Scopus3 WoS2
    2017 Naqvi, A., Khedraki, R., Li, J., Chou, L. -D., Ramalingam, T., & Patel, P. (2017). HYBRID IVUS/OCT: "PROBING" THE FUTURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69(11), 976.
    DOI
    2017 Li, J., Quirk, B., Noble, P., Kirk, R., Sampson, D., & McLaughlin, R. (2017). Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration. Journal of Biomedical Optics, 22(10), 106002-1-106002-5.
    DOI Scopus3 WoS3
    2016 Li, J. (2016). 基于光学系统的血管内高集成多模态成像技术. 中国激光, 43(12), 1-13.
    DOI
    2016 Li, J., & Chen, Z. (2016). Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]. Journal of Biomedical Photonics & Engineering, 1(4), 209-224.
    DOI
    2015 Li, J., Minami, H., Steward, E., Ma, T., Mohar, D., Robertson, C., . . . Chen, Z. (2015). Optimal flushing agents for integrated optical and acoustic imaging systems. Journal of Biomedical Optics, 20(5), 056005.
    DOI WoS3 Europe PMC2
    2015 Li, J. (2015). Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo. Scientific Reports, 5(1), 1-7.
    DOI WoS11 Europe PMC9
    2015 Piao, Z., Ma, T., Li, J., Wiedmann, M., Huang, S., Yu, M., . . . Chen, Z. (2015). High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm. Applied Physics Letters, 107(8), 083701-1-083701-4.
    DOI WoS27 Europe PMC19
    2015 Ma, T., Yu, M., Chen, Z., Fei, C., Shung, K., & Zhou, Q. (2015). Multi-Frequency Intravascular Ultrasound (IVUS) Imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 62(1), 97-107.
    DOI WoS52 Europe PMC23
    2015 Ma, T., Yu, M., Li, J., Munding, C. E., Chen, Z., Fei, C., . . . Zhou, Q. (2015). Multi-Frequency Intravascular Ultrasound (IVUS) Imaging (vol 62, pg 97, 2015). IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(3), 604.
    DOI WoS1
    2014 Liang, S., Ma, T., Jing, J., Li, X., Li, J., Kirk Shung, K., . . . Chen, Z. (2014). Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging. Optics Letters, 39(23), 1-10.
    DOI WoS14 Europe PMC8
    2014 Li, J., Ma, T., Mohar, D., Correa, A., Zhou, Q., Patel, P. M., & Chen, Z. (2014). Integrated intravascular ultrasound (IVUS) optical coherence tomography (OCT) system for identifying thin-cap fibroatheroma. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11), B111.
    DOI
    2014 Li, J., Ma, T., Mohar, D., Correa, A., Zhou, Q., Chen, Z., & Patel, P. M. (2014). Human coronary plaque characterization using a fully integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11), B108.
    DOI
    2014 Li, X., Li, J., Jing, J., Ma, T., Liang, S., Zhang, J., . . . Chen, Z. (2014). Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 20(2), 8 pages.
    DOI WoS28 Europe PMC12
    2014 Li, J., Li, X., Mohar, D., Raney, A., Jing, J., Zhang, J., . . . Chen, Z. (2014). Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis. JACC-CARDIOVASCULAR IMAGING, 7(1), 101-103.
    DOI WoS25 Europe PMC16
    2013 Li, J., Ma, T., Jing, J., Zhang, J., Patel, P., Kirk Shung, K., . . . Chen, Z. (2013). Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display. Journal of Biomedical Optics, 18(10), 100502.
    DOI WoS15 Europe PMC10
    2013 Qi, W., Li, R., Ma, T., Li, J., Kirk Shung, K., Zhou, Q., & Chen, Z. (2013). Resonant acoustic radiation force optical coherence elastography. Applied Physics Letters, 103(10), 103704-1-103704-5.
    DOI WoS37 Europe PMC27
    2012 Liang, S., Saidi, A., Jing, J., Liu, G., Li, J., Zhang, J., . . . Chen, Z. (2012). Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner. Journal of Biomedical Optics, 17(7), 070501-1-070501-3.
    DOI WoS46 Europe PMC23
    2012 Li, J., Li, X., Jing, J., Mohar, D., Raney, A., Mahon, S., . . . Chen, Z. (2012). Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo. 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2012, 3175-3178.
    DOI WoS4 Europe PMC3
    2011 Yin, J., Li, X., Jing, J., Li, J., Mukai, D., Mahon, S., . . . Chen, Z. (2011). Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging. Journal of Biomedical Optics, 16(6), 060505-1-060505-3.
    DOI WoS40 Europe PMC22
    2010 Meng, J., Ding, Z., Li, J., Wang, K., & Wu, T. (2010). Transit-time analysis based on delay-encoded beam shape for velocity vector quantification by spectral-domain Doppler optical coherence tomography. OPTICS EXPRESS, 18(2), 1261-1270.
    DOI WoS9 Europe PMC4

  • Conference Papers
    Year Citation
    2016 Piao, Z., Teng, M., Li, J., Qu, Y., Yu, M., Shung, K. K., . . . Chen, Z. (2016). High speed photoacoustic imaging with fast OPO laser at 1.7 pm (Conference Presentation). In A. Oraevsky, & L. Wang (Eds.), PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016 Vol. 9708 (pp. 1 page). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2015 Li, J., Ma, T., Cummins, T., Shung, K. K., Van Damb, J., Zhou, Q., & Chen, Z. (2015). Integrated OCT-US Catheter for Detection of Cancer in the Gastrointestinal Tract. In M. Suter, S. Lam, M. Brenner, G. Tearney, & T. Wang (Eds.), ENDOSCOPIC MICROSCOPY X; AND OPTICAL TECHNIQUES IN PULMONARY MEDICINE II Vol. 9304 (pp. 5 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2015 Li, J., Minami, H., Steward, E., Ma, T., Mohar, D., Robertson, C., . . . Chen, Z. (2015). Ideal flushing agents for integrated optical acoustic imaging systems. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI Vol. 9303 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2014 Li, J., Ma, T., Jing, J., Zhang, J., Patel, P. M., Shung, K. K., . . . Chen, Z. (2014). Back-to-back optical coherence tomography-ultrasound probe for co-registered three-dimensional intravascular imaging with real-time display. In J. Izatt, J. Fujimoto, & V. Tuchin (Eds.), OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVIII Vol. 8934 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2014 Li, J., Ma, T., Mohar, D., Correa, A., Minami, H., Jing, J., . . . Chen, Z. (2014). Diagnostic accuracy of an integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS X Vol. 8926 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI WoS2
    2014 Li, J., Zhang, J., Chou, L., Wang, A., Jing, J., & Chen, Z. (2014). Self optical motion-tracking for endoscopic Optical coherence tomography probe using micro-beamsplitter probe. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS X Vol. 8926 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2013 Ma, T., Li, J., Jing, J., Li, X., Patee, P. M., Shung, K. K., . . . Zhou, Q. (2013). Real-time Co-registered IVUS-OCT Catheter for Atherosclerotic Plaque Identification. In 2013 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) (pp. 769-772). Prague, CZECH REPUBLIC: IEEE.
    DOI
    2012 Li, J., Yin, J., Li, X., Jing, J., Mukai, D., Mahon, S., . . . Chen, Z. (2012). Miniature integrated optical coherence tomography (OCT) - ultrasound (US) probe for intravascular imaging. In N. Kollias, B. Choi, H. Zeng, H. Kang, B. Knudsen, B. Wong, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2 Vol. 8207 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI
    2012 Jing, J., Li, J., Li, X., Yin, J., Zhang, J., Hoang, K., . . . Chen, Z. (2012). Advances in a fully integrated intravascular OCT-Ultrasound system for cardiovascular imaging. In J. Izatt, J. Fujimoto, & V. Tuchin (Eds.), OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI Vol. 8213 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
    DOI WoS1
    2012 Li, X., Li, J., Jing, J., Ma, T., Mohar, D., Raney, A., . . . Zhou, Q. (2012). Integrated IVUS-OCT Catheter for In Vivo Intravascular Imaging. In 2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) (pp. 1564-1567). Dresden, GERMANY: IEEE.
    DOI

1. 2018 - Australian Heart Foundation Postdoctoral Fellowship (CIA: Jiawen Li)

Funding amount: $150,000 by Heart Foundation, and over $300,000 by the administering institution; Project title: Miniaturised multimodal intravascular catheter for in vivo longitudinal studies of high-risk plaques—simultaneous near-infrared fluorescence (NIRF) molecular imaging and optical coherence tomography microstructural imaging.

2. 2018 - South Australia Photonics Catalyst Program grant (CIA: Jiawen Li)

Funding amount: $45,000

3. 2018 - Faculty of Health and Medical Sciences Emerging Leadership Mentored Development Program (CIA: Jiawen Li)

Funding amount: $39,170

4. 2018 - Australia-Germany Joint Research Copperation Scheme (UA-DAAD, CIA: Jiawen Li)

Funding amount: $20,320+EURO16,000; Project title: 3D printed freeform micro-optics for simultaneous OCT and fluorescence intravascular imaging

5. 2018 - Australia-Germany Joint Research Copperation Scheme (UA-DAAD, as CIB)

Funding amount: $22,000+EURO16,000; Project title: Improved detection of dental disease using a low-cost, high-resolution optical coherence tomography imaging probe

6. 2018 - Faculty of Health and Medical Sciences Research Infrastructure Funding Awards (as CIC)

Funding amount: $20,000.

7. 2018- ARC Centre of Excellence for Nanoscale BioPhotonics Small Equipment Grant (CIA: Jiawen Li)

Funding amount: $5000

8. 2017 - Faculty of Health and Medical Sciences Research Infrastructure Funding Awards (as CIB)

Funding amount: $20,000

9. 2017 - Pilot Project Grant, Institute of Photonics and Advance Sensing (IPAS, CIA: Jiawen Li)

Funding amount: $8,000

10. 2015 - Healy Research Collaboration award, Raine Medical research foundation (CIA: Jiawen Li)

Funding amount: $10,000. This is a grant to support early career researcher to independently lead translational research.

  Institute Year Topic
Guest Lecturer Polytechnique Montreal 2017 Optical coherence tomography
Guest Lecturer University of Southern California 2013 Optical coherence tomography

 

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  • Committee Memberships
    Date Role Committee Institution Country
    2018 - ongoing Co-Chair CLEO-PR 2020 Technical Program Committee, BioPhotonics Pacific Rim Conference on Lasers and Electro-Optics (CLEO-PR 2020) Australia
    2018 - ongoing Co-Chair BLiSS Adelaide Conference Committee BLiSS Adelaide Australia
    2018 - ongoing Member IEEE Photonics Conference 2019 Biophotonics Technical Program Committee IEEE Photonics Conference United States
    2018 - ongoing Member Technical Program Committee, 2019 Asia-Pacific Optical Sensors Conference (APOS) 2019 Asia-Pacific Optical Sensors Conference Australia
    2018 - ongoing Member Seminar Series Organising Committee, Faculty of Health and Medical Sciences Faculty of Health and Medical Sciences Australia
    2018 - ongoing Member Technical Program Committee of the AIP Congress with AOS Conference and ACOFT Australian Optical Society Australia
    2017 - ongoing Member IPAS Scientific Leadership Committee (SLC) Institute for Photonics and Advanced Sensing Australia
    2017 - ongoing Chair IPAS Science Network Committee Institute for Photonics and Advanced Sensing Australia
  • Position: Lecturer
  • Phone: 83138187
  • Email: jiawen.li01@adelaide.edu.au
  • Campus: North Terrace
  • Building: The Braggs, floor 2
  • Room: 2 11
  • Org Unit: Adelaide Medical School
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