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Dr Jiawen Li

Jiawen Li
Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr. Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. Her research interests include optical coherence tomography (OCT), imaging+sensing fibre-optic probes, Doppler OCT, multimodality imaging and ultra-thin endoscopes.

Her PhD research focused on the development of highly novel multimodal miniaturized fibre-optic imaging probes, where they fully integrated two or more complementary imaging modalities in one single unit.
After the completion of her PhD, She joined University of Western Australian (UWA) to lead the development of a flexible fibre-optic needle probe. Extended from this project, she proposed an innovative fibre-optic probe design that can provide co-localized imaging and aspiration. This was the cornerstone idea of an awarded grant (as the lead CI) and a journal publication (as the first and corresponding author, which also won IPAS Best ECR Paper Award).
In April 2016, she moved with her supervisor, Prof Robert McLaughlin, to University of Adelaide (UoA) to establish their new lab. They conducted a successful pilot clinical trial of our smart brain needle probes in 11 patients undergoing neurosurgery in late 2016. The tiny probe lets surgeons 'see' at-risk blood vessels as they insert the biopsy needle, allowing them to avoid causing potentially fatal bleeds. The results have been highlighted by ‘making a difference: outcomes of ARC supported research’.
Since 2017, she began to establish her own independent research area by actively applying for grants and delivering them. 1) As the lead CI of an awarded pilot project grant, she was able to investigate and demonstrate the first single-fibre based fibre-optic probe that can conduct imaging and temperature sensing simultaneously. 2) Strategically using the funding of her women’s research excellence award, she developed my unique expertise of 3D printing freeform micro-optics for fibre-optic probes (first-author journal paper under in-depth review by Scientific Reports) and strengthened her collaborative work on developing biocompatible fibre coatings. 3) Combining her unique expertise in fibre-optic probes and experience in research translation, she partner with Miniprobes Pty Ltd, a high-tech Australian start-up company, to translate our research outcomes to products suitable for industrial applications. She was recently awarded South Australian Government funding ‘Photonics Catalyst Program’, to support a University-Industry translational research project to develop fibre-optic imaging probes for the non-destructive testing market.

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Dr Jiawen Li

Dr. Jiawen Li received her BS degree in Optical Engineering from Zhejiang University in 2010, and her PhD degree in Biomedical Engineering from University of California Irvine in 2015. Her research interests include optical coherence tomography (OCT), imaging+sensing fibre-optic probes, Doppler OCT, multimodality imaging and ultra-thin endoscopes.

Her PhD research focused on the development of highly novel multimodal miniaturized fibre-optic imaging probes, where they fully integrated two or more complementary imaging modalities in one single unit.
After the completion of her PhD, She joined University of Western Australian (UWA) to lead the development of a flexible fibre-optic needle probe. Extended from this project, she proposed an innovative fibre-optic probe design that can provide co-localized imaging and aspiration. This was the cornerstone idea of an awarded grant (as the lead CI) and a journal publication (as the first and corresponding author, which also won IPAS Best ECR Paper Award).
In April 2016, she moved with her supervisor, Prof Robert McLaughlin, to University of Adelaide (UoA) to establish their new lab. They conducted a successful pilot clinical trial of our smart brain needle probes in 11 patients undergoing neurosurgery in late 2016. The tiny probe lets surgeons 'see' at-risk blood vessels as they insert the biopsy needle, allowing them to avoid causing potentially fatal bleeds. The results have been highlighted by ‘making a difference: outcomes of ARC supported research’.
Since 2017, she began to establish her own independent research area by actively applying for grants and delivering them. 1) As the lead CI of an awarded pilot project grant, she was able to investigate and demonstrate the first single-fibre based fibre-optic probe that can conduct imaging and temperature sensing simultaneously. 2) Strategically using the funding of her women’s research excellence award, she developed my unique expertise of 3D printing freeform micro-optics for fibre-optic probes (first-author journal paper under in-depth review by Scientific Reports) and strengthened her collaborative work on developing biocompatible fibre coatings. 3) Combining her unique expertise in fibre-optic probes and experience in research translation, she partner with Miniprobes Pty Ltd, a high-tech Australian start-up company, to translate our research outcomes to products suitable for industrial applications. She was recently awarded South Australian Government funding ‘Photonics Catalyst Program’, to support a University-Industry translational research project to develop fibre-optic imaging probes for the non-destructive testing market.

Eligible to supervise Masters and PhD (as Co-Supervisor) — email supervisor to discuss availability.

High-resolution optical imaging technologies have rapidly gained importance, and a range of antibody-specific fluorescent biomarkers have driven new insights in disease mechanisms. However, optical techniques degrade rapidly in solid tissue due to absorption and multiple scattering of the photons, limiting their imaging depth and largely restricting their use to cell culture. To overcome this limit, we have been developing a series of multi-modal minimally-invasive imaging probes.

We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single-fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches
We recently invented a world-first tiny fibre-optic probe that can simultaneously measure temperature and see deep inside the body. Combining optical imaging and sensing technologies into a single fibre (size of human hair) will enable researchers to unravel fundamental biological processes in vivo in a minimal invasive way, which are not accessible using present approaches.

https://phys.org/news/2018-04-tiny-probe-body-temperatures.html 

http://freshscience.org.au/state/sa/tiny-probe

https://www.nibib.nih.gov/news-events/newsroom/two-imaging-catheters-unite-better-detect-dangerous-plaques-arteries

http://www.octnews.org/articles/5026989/feature-of-the-week-11-24-13-miniature-oct-ivus-pr/

https://www.youtube.com/watch?v=Ag13_fxoARA

Appointments

Date Position Institution name
2016 Postdoctoral Researcher-Lecturer (research-only) University of Adelaide
2015 - 2016 Research Fellow University of Western Australia
2014 - 2014 R&D intern St. Jude Medical (United States)

Awards and Achievements

Date Type Title Institution Name Country Amount
2018 Research Award IPAS Best Early Career Researcher (ECR) Paper Award Institute for Photonics and Advanced Sensing Australia
2017 Research Award Women's Research Excellence Award The University of Adelaide $5000
2016 Research Award Research Travel award Adelaide Medical School Australia $3000
2016 Award Best poster award The International Conference on Information Optics and Photonics China
2015 Award Robert Newcomb Interdisciplinary Team Science Award University of California, Irvine United States
2015 Award Best technical poster Optics in Cardiology conference Netherlands $1100
2015 Fellowship Public Impact Fellow UC Irvine United States $650
2013 Award Community Award University of California, Irvine United States
2012 Honour Student Spotlight Report University of California, Irvine United States
2012 Achievement 3rd Place in Business Plan Competition, Life Science Division University of California, Irvine United States $3250
2011 Fellowship Graduate Growth Incentive Awards Fellowship University of California, Irvine United States ~$60000

Education

Date Institution name Country Title
2012 - 2015 University of California, Irvine USA PhD
2010 - 2012 University of California, Irvine USA Master
2006 - 2010 Zhejiang University China Bachelor of science

Research Interests

Journals

Year Citation
2018 Li, J. (2018). Perspective: Biomedical sensing and imaging with optical fibers-Innovation through convergence of science disciplines. APL Photonics, 3(10), 20 pages.
2018 Li, J., & E. Schartner, S. Musolino, B. Quirk, R. Kirk, H. Ebendorff-Heidepriem, R. McLaughlin. (2018). Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue. Optics Letters, 43(8), 1682-1685.
DOI
2017 Naqvi, A., Khedraki, R., Li, J., Chou, L. -D., Ramalingam, T., & Patel, P. (2017). HYBRID IVUS/OCT: "PROBING" THE FUTURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69(11), 976.
DOI
2017 Li, J., Quirk, B., Noble, P., Kirk, R., Sampson, D., & McLaughlin, R. (2017). Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration. Journal of Biomedical Optics, 22(10), 106002-1-106002-5.
DOI Scopus1
2016 Li, J. (2016). 基于光学系统的血管内高集成多模态成像技术. 中国激光, 43(12), 1-13.
2016 Li, J., & Chen, Z. (2016). Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]. Journal of Biomedical Photonics & Engineering, 1(4), 209-224.
DOI
2015 Li, J., Minami, H., Steward, E., Ma, T., Mohar, D., Robertson, C., . . . Chen, Z. (2015). Optimal flushing agents for integrated optical and acoustic imaging systems. Journal of Biomedical Optics, 20(5), 056005.
DOI WoS2 Europe PMC1
2015 Li, J. (2015). Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo. Scientific Reports, 5(1), 1-7.
DOI WoS12 Europe PMC8
2015 Piao, Z., Ma, T., Li, J., Wiedmann, M., Huang, S., Yu, M., . . . Chen, Z. (2015). High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm. Applied Physics Letters, 107(8), 083701-1-083701-4.
DOI WoS20 Europe PMC12
2015 Ma, T., Yu, M., Chen, Z., Fei, C., Shung, K., & Zhou, Q. (2015). Multi-Frequency Intravascular Ultrasound (IVUS) Imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 62(1), 97-107.
DOI WoS35 Europe PMC16
2015 Ma, T., Yu, M., Li, J., Munding, C. E., Chen, Z., Fei, C., . . . Zhou, Q. (2015). Multi-Frequency Intravascular Ultrasound (IVUS) Imaging (vol 62, pg 97, 2015). IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(3), 604.
DOI WoS1
2014 Liang, S., Ma, T., Jing, J., Li, X., Li, J., Kirk Shung, K., . . . Chen, Z. (2014). Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging. Optics Letters, 39(23), 1-10.
WoS10 Europe PMC6
2014 Li, J., Ma, T., Mohar, D., Correa, A., Zhou, Q., Patel, P. M., & Chen, Z. (2014). Integrated intravascular ultrasound (IVUS) optical coherence tomography (OCT) system for identifying thin-cap fibroatheroma. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11), B111.
DOI
2014 Li, J., Ma, T., Mohar, D., Correa, A., Zhou, Q., Chen, Z., & Patel, P. M. (2014). Human coronary plaque characterization using a fully integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11), B108.
DOI
2014 Li, X., Li, J., Jing, J., Ma, T., Liang, S., Zhang, J., . . . Chen, Z. (2014). Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 20(2), 8 pages.
DOI WoS22 Europe PMC12
2014 Li, J., Li, X., Mohar, D., Raney, A., Jing, J., Zhang, J., . . . Chen, Z. (2014). Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis. JACC-CARDIOVASCULAR IMAGING, 7(1), 101-103.
DOI WoS18 Europe PMC11
2013 Li, J., Ma, T., Jing, J., Zhang, J., Patel, P., Kirk Shung, K., . . . Chen, Z. (2013). Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display. Journal of Biomedical Optics, 18(10), 100502.
DOI WoS14 Europe PMC9
2013 Qi, W., Li, R., Ma, T., Li, J., Kirk Shung, K., Zhou, Q., & Chen, Z. (2013). Resonant acoustic radiation force optical coherence elastography. Applied Physics Letters, 103(10), 103704-1-103704-5.
DOI WoS31 Europe PMC19
2012 Liang, S., Saidi, A., Jing, J., Liu, G., Li, J., Zhang, J., . . . Chen, Z. (2012). Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner. Journal of Biomedical Optics, 17(7), 070501-1-070501-3.
DOI WoS30 Europe PMC19
2012 Li, J., Li, X., Jing, J., Mohar, D., Raney, A., Mahon, S., . . . Chen, Z. (2012). Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo. 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2012, 3175-3178.
DOI WoS3 Europe PMC3
2011 Yin, J., Li, X., Jing, J., Li, J., Mukai, D., Mahon, S., . . . Chen, Z. (2011). Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging. Journal of Biomedical Optics, 16(6), 060505-1-060505-3.
DOI WoS32 Europe PMC19
2010 Meng, J., Ding, Z., Li, J., Wang, K., & Wu, T. (2010). Transit-time analysis based on delay-encoded beam shape for velocity vector quantification by spectral-domain Doppler optical coherence tomography. OPTICS EXPRESS, 18(2), 1261-1270.
DOI WoS9 Europe PMC4

Conference Papers

Year Citation
2016 Piao, Z., Teng, M., Li, J., Qu, Y., Yu, M., Shung, K. K., . . . Chen, Z. (2016). High speed photoacoustic imaging with fast OPO laser at 1.7 pm (Conference Presentation). In A. Oraevsky, & L. Wang (Eds.), PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2016 Vol. 9708 (pp. 1 page). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2015 Li, J., Ma, T., Cummins, T., Shung, K. K., Van Damb, J., Zhou, Q., & Chen, Z. (2015). Integrated OCT-US Catheter for Detection of Cancer in the Gastrointestinal Tract. In M. Suter, S. Lam, M. Brenner, G. Tearney, & T. Wang (Eds.), ENDOSCOPIC MICROSCOPY X; AND OPTICAL TECHNIQUES IN PULMONARY MEDICINE II Vol. 9304 (pp. 5 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2015 Li, J., Minami, H., Steward, E., Ma, T., Mohar, D., Robertson, C., . . . Chen, Z. (2015). Ideal flushing agents for integrated optical acoustic imaging systems. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI Vol. 9303 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2014 Li, J., Ma, T., Jing, J., Zhang, J., Patel, P. M., Shung, K. K., . . . Chen, Z. (2014). Back-to-back optical coherence tomography-ultrasound probe for co-registered three-dimensional intravascular imaging with real-time display. In J. Izatt, J. Fujimoto, & V. Tuchin (Eds.), OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVIII Vol. 8934 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2014 Li, J., Ma, T., Mohar, D., Correa, A., Minami, H., Jing, J., . . . Chen, Z. (2014). Diagnostic accuracy of an integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS X Vol. 8926 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI WoS2
2014 Li, J., Zhang, J., Chou, L., Wang, A., Jing, J., & Chen, Z. (2014). Self optical motion-tracking for endoscopic Optical coherence tomography probe using micro-beamsplitter probe. In B. Choi, N. Kollias, H. Zeng, H. Kang, B. Wong, J. Ilgner, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS X Vol. 8926 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2013 Ma, T., Li, J., Jing, J., Li, X., Patee, P. M., Shung, K. K., . . . Zhou, Q. (2013). Real-time Co-registered IVUS-OCT Catheter for Atherosclerotic Plaque Identification. In 2013 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) (pp. 769-772). Prague, CZECH REPUBLIC: IEEE.
DOI
2012 Li, J., Yin, J., Li, X., Jing, J., Mukai, D., Mahon, S., . . . Chen, Z. (2012). Miniature integrated optical coherence tomography (OCT) - ultrasound (US) probe for intravascular imaging. In N. Kollias, B. Choi, H. Zeng, H. Kang, B. Knudsen, B. Wong, . . . A. Mandelis (Eds.), PHOTONIC THERAPEUTICS AND DIAGNOSTICS VIII, PTS 1 AND 2 Vol. 8207 (pp. 7 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2012 Jing, J., Li, J., Li, X., Yin, J., Zhang, J., Hoang, K., . . . Chen, Z. (2012). Advances in a fully integrated intravascular OCT-Ultrasound system for cardiovascular imaging. In J. Izatt, J. Fujimoto, & V. Tuchin (Eds.), OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI Vol. 8213 (pp. 6 pages). San Francisco, CA: SPIE-INT SOC OPTICAL ENGINEERING.
DOI
2012 Li, X., Li, J., Jing, J., Ma, T., Mohar, D., Raney, A., . . . Zhou, Q. (2012). Integrated IVUS-OCT Catheter for In Vivo Intravascular Imaging. In 2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) (pp. 1564-1567). Dresden, GERMANY: IEEE.
DOI

1. 2018 – South Australia Photonics Catalyst Program grant

Funding amount $45,000; J. Li is the lead CI of the proposal.

2. 2017 - Faculty of Health and Medical Sciences Research Infrastructure Funding Awards

Funding amount $20,000; J. Li is the second CI of this proposal.

3. 2017 - Pilot Project Grant, Institute of Photonics and Advance Sensing (IPAS)

Funding amount $8,000; J. Li is the lead CI of this proposal.

4. 2015 - Travel award, UoA

Award amount $3,000; J. Li is the only CI of this grant.

5. 2015 - Healy Research Collaboration award, Raine Medical research foundation

Funding amount $10,000; J. Li is the lead CI of this proposal. This is a grant to support early career researcher to independently lead translational research.

  Institute Year Topic
Guest Lecturer Polytechnique Montreal 2017 Optical coherence tomography
Guest Lecturer University of Southern California 2013 Optical coherence tomography

 

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Co-Supervisor Fiber Imaging Doctor of Philosophy Doctorate Full Time Ms Lu Peng

Other Supervision Activities

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2018 - ongoing Co-Supervisor High resolution microstructured optical fiber sensor The University of Adelaide Doctorate Lu Peng

Committee Memberships

Date Role Committee Institution Country
2018 - ongoing Member Technical Program Committee of the AIP Congress with AOS Conference and ACOFT
2017 - ongoing Member IPAS Science Management Committee
2017 - ongoing Chair IPAS Science Network Committee
Position
Lecturer
Phone
83138187
Campus
North Terrace
Building
Helen Mayo North
Org Unit
Adelaide Medical School

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