Malaria parasites persist as significant human pathogens worldwide. My research aims to elucidate the roles of essential proteins involved in the invasion and infection of host cells by both human and zoonotic malaria parasites. Given the unique strategy of invading host cells for survival, many proteins involved in this process remain enigmatic. We hope to develop a comprehensive model delineating the protein network facilitating malaria parasite entry into host cell by applying novel imaging and proteomics techniques applicable to other cellular systems. This work will culminate in the potential identification of novel therapeutic targets.