Jan Kazenwadel

Dr Jan Kazenwadel

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


Year Citation
2024 Panara, V., Yu, H., Peng, D., Staxäng, K., Hodik, M., Filipek-Gorniok, B., . . . Koltowska, K. (2024). Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds. Development, 151(9), dev202525-1-dev202525-14.
DOI Scopus8 WoS8 Europe PMC9
2024 Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. J. (2024). Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nature Communications, 15(1), 7097-1-7097-21.
DOI Scopus16 WoS16 Europe PMC14
2023 Kazenwadel, J., Venugopal, P., Oszmiana, A., Toubia, J., Arriola-Martinez, L., Panara, V., . . . Harvey, N. L. (2023). A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature, 614(7947), 343-348.
DOI Scopus37 WoS41 Europe PMC41
2023 Chiang, I. K. N., Graus, M. S., Kirschnick, N., Davidson, T., Luu, W., Harwood, R., . . . Francois, M. (2023). The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO Journal, 42(5, article no. e109032), 1-23.
DOI Scopus10 WoS10 Europe PMC11
2022 Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15.
DOI Scopus44 WoS36 Europe PMC38
2020 Betterman, K. L., Sutton, D. L., Secker, G. A., Kazenwadel, J., Oszmiana, A., Lim, L., . . . Harvey, N. L. (2020). Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Journal of Clinical Investigation, 130(6), 3315-3328.
DOI Scopus59 WoS56 Europe PMC57
2018 Frye, M., Taddei, A., Dierkes, C., Martinez-Corral, I., Fielden, M., Ortsäter, H., . . . Mäkinen, T. (2018). Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nature Communications, 9(1), 1511-1-1511-16.
DOI Scopus149 WoS139 Europe PMC141
2018 Kazenwadel, J., & Harvey, N. L. (2018). Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis. Current Opinion in Immunology, 53, 81-87.
DOI Scopus26 WoS23 Europe PMC24
2016 Kazenwadel, J., & Harvey, N. (2016). Morphogenesis of the lymphatic vasculature: a focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels. Developmental Dynamics, 245(3), 209-219.
DOI Scopus33 WoS29 Europe PMC26
2015 Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994.
DOI Scopus206 WoS189 Europe PMC186
2014 Bowles, J., Secker, G., Nguyen, C., Kazenwadel, J., Truong, V., Frampton, E., . . . Francois, M. (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386(1), 25-33.
DOI Scopus40 WoS35 Europe PMC39
2014 Kartopawiro, J., Bower, N., Karnezis, T., Kazenwadel, J., Betterman, K., Lesieur, E., . . . Hogan, B. (2014). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, 23(5), 1286-1297.
DOI Scopus30 WoS29 Europe PMC31
2013 Paterson, E., Kazenwadel, J., Bert, A., Khew-Goodall, Y., Ruszkiewicz, A., & Goodall, G. (2013). Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia, 15(2), 180-191.
DOI Scopus152 WoS143 Europe PMC131
2012 Kazenwadel, J., Secker, G., Betterman, K., & Harvey, N. (2012). In Vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis. PLoS One, 7(7), 1-12.
DOI Scopus38 WoS35 Europe PMC39
2012 Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291.
DOI Scopus254 WoS219 Europe PMC212
2011 Bastian, I., Tam Tam, S., Zhou, X., Kazenwadel, J., Van Der Hoek, M., Michael, M., . . . Haberberger, R. (2011). Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochemistry and Cell Biology, 135(1), 37-45.
DOI Scopus17 WoS16 Europe PMC17
2010 Kazenwadel, J., Michael, M., & Harvey, N. (2010). Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood, 116(13), 2395-2401.
DOI Scopus143 WoS140 Europe PMC133
2002 Dziadek, M., Kazenwadel, J. S., A. Hendrey, J., Pan, T. C., Zhang, R. Z., & Chu, M. L. (2002). Alternative splicing of transcripts for the alpha3 chain of mouse collagen VI: Identification of an abundant isoform lacking domains N7-N10 in mouse and human. Matrix Biology, 21(3), 227-241.
DOI Scopus15 WoS13 Europe PMC14
2001 Williams, R., Manji, S., Parker, N., Hancock, M., van Stekelenburg, L., Eid, J., . . . Dziadek, M. (2001). Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. Biochemical Journal, 357(Part 3), 673-685.
DOI Scopus288 WoS268 Europe PMC197
1994 James, R., Erler, T., & Kazenwadel, J. (1994). Structure of the Murine Homeobox Gene cdx-2: Expression in Embryonic and Adult Intestinal Epithelium. Journal of Biological Chemistry, 269(21), 15229-15237.
DOI Scopus272 WoS272 Europe PMC213
1993 Hu, Y., Kazenwadel, J., & James, R. (1993). Isolation and characterization of the murine homeobox gene Cdx-1: Regulation of expression in intestinal epithelial cells. Journal of Biological Chemistry, 268(36), 27214-27225.
DOI Scopus60 WoS64 Europe PMC49
1991 James, R., & Kazenwadel, J. (1991). Homeobox gene expression in the intestinal epithelium of adult mice. Journal of Biological Chemistry, 266(5), 3246-3251.
DOI Scopus203 WoS206 Europe PMC165
1989 James, R., & Kazenwadel, J. (1989). T-cell nuclei contain a protein that binds upstream of the murine granulocyte-macrophage colony-stimulating factor gene. Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7392-7396.
DOI Scopus5 WoS7 Europe PMC2

Date Role Research Topic Program Degree Type Student Load Student Name
2023 Co-Supervisor Understanding the genetic and developmental basis of human lymphatic vascular disease Doctor of Philosophy Doctorate Full Time Miss Ushani Mallawa Arachchige

Date Role Research Topic Program Degree Type Student Load Student Name
2022 - 2026 Co-Supervisor Defining the mechanisms by which GATA2 programs lymphatic vessel valve developmen Doctor of Philosophy Doctorate Full Time Mr Ivan Ngui Qi Han

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