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Eichner, H., Wu, C., Cammer, M., Tran, E. N. H., Hirst, T. R., Paton, J. C., & Weiser, J. N. (2025). Intra-serotype variation of Streptococcus pneumoniae capsule and its quantification. Microbiology Spectrum, 13(4), 18 pages.
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Gates, C. J., Brazel, E. B., Kennedy, E. V., Brown, J. S., Ercoli, G., Davies, J., . . . Alsharifi, M. (2025). A gamma-irradiated pneumococcal vaccine elicits superior immunogenicity in comparison to heat or chemically inactivated whole-cell vaccines. Vaccine, 54, 10 pages.
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Srivastava, V., Liu, Z., Wei, W., Zhang, Y., Paton, J. C., Paton, A. W., . . . Zhang, B. (2025). Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion. Biomolecules, 15(4), 458-1-458-17.
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Barros, D., Ferreira, B. H., Garcia-Gonzalez, P., Carbone, F., Luka, M., Leite-Pinheiro, F., . . . Pierre, P. (2025). Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation. Proceedings of the National Academy of Sciences of USA, 122(21), e2421258122-1-e2421258122-12.
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Ferreira, B. H., Silva, I. S., Mendes, A., Leite-Pinheiro, F., Paton, A. W., Paton, J. C., . . . Almeida, C. R. (2025). Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation. Cell Communication and Signaling, 23(1), 12 pages.
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Song, Z., Thepsuwan, P., Hur, W. S., Torres, M., Wu, S. A., Wei, X., . . . Sun, S. (2024). Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD. Nature Communications, 15(1), 9244-1-9244-17.
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Shearer, H. L., Currie, M. J., Agnew, H. N., Trappetti, C., Stull, F., Pace, P. E., . . . Dickerhof, N. (2024). Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae.. J Biol Chem, 300(5), 107282.
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Marks, I. R. M., Doyle, L. W., Mainzer, R. M., Spittle, A. J., Clark, M., Boland, R. A., . . . Cheong, J. L. Y. (2024). Neurosensory, cognitive and academic outcomes at 8 years in children born 22-23 weeks' gestation compared with more mature births. Archives of Disease in Childhood: Fetal and Neonatal Edition, 109(5), 511-518.
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Zhang, P. P., Benske, T. M., Ahn, L. Y., Schaffer, A. E., Paton, J. C., Paton, A. W., . . . Wang, Y. J. (2024). Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants. Acta Pharmacologica Sinica, 45(2), 282-297.
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Brazel, E. B., Alsharifi, M., Giorgio, L., Hirst, T., & Paton, J. (2024). Whole-cell pneumococcal vaccines: a future-proof approach to overcoming pneumococcal serotype replacement. Vaccine Insights, 3(1), 17-22.
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Duan, J., Matute, J. D., Unger, L. W., Hanley, T., Schnell, A., Lin, X., . . . Blumberg, R. S. (2023). Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut. Immunity, 56(5), 1115-1131.
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Agnew, H. N., Atack, J. M., Fernando, A. R. D., Waters, S. N., van der Linden, M., Smith, E., . . . Trappetti, C. (2023). Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates. Frontiers in Cellular and Infection Microbiology, 13, 1-12.
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Ostermann, L., Seeliger, B., David, S., Flasche, C., Maus, R., Reinboth, M. S., . . . Maus, U. A. (2023). S100A9 is indispensable for survival of pneumococcal pneumonia in mice. Plos Pathogens, 19(7 July), 31 pages.
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Shewell, L. K., Day, C. J., Hippolite, T., De Bisscop, X., Paton, J. C., Paton, A. W., & Jennings, M. P. (2023). Serum Neu5Gc biomarkers are elevated in primary cutaneous melanoma. Biochemical and Biophysical Research Communications, 642, 162-166.
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Tran, D. T., Pottekat, A., Lee, K., Raghunathan, M., Loguercio, S., Mir, S. A., . . . Itkin-Ansari, P. (2022). Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets (vol 107, pg 3100, 2022). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 108(4), 1 page.
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Tikhomirova, A., Brazel, E. B., McLean, K. T., Agnew, H. N., Paton, J. C., & Trappetti, C. (2022). The Role of luxS in the Middle Ear Streptococcus pneumoniae Isolate 947. Pathogens, 11(2), 216-1-216-12.
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Shearer, H. L., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid.. Free radical biology & medicine, 179, 24-33.
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Agnew, H. N., Brazel, E. B., Tikhomirova, A., van der Linden, M., McLean, K. T., Paton, J. C., & Trappetti, C. (2022). Streptococcus pneumoniae Strains Isolated From a Single Pediatric Patient Display Distinct Phenotypes. Frontiers in Cellular and Infection Microbiology, 12, 1-16.
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Shewell, L. K., Day, C. J., Kutasovic, J. R., Abrahams, J. L., Wang, J., Poole, J., . . . Jennings, M. P. (2022). N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease. BMC Cancer, 22(1), 1-11.
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Avila, H., Yu, J., Boddu, G., Phan, A., Truong, A., Peddi, S., . . . MacKay, J. A. (2022). Hydra-Elastin-like Polypeptides Increase Rapamycin Potency When Targeting Cell Surface GRP78. Biomacromolecules, 23(8), 3116-3129.
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Tikhomirova, A., Zilm, P. S., Trappetti, C., Paton, J. C., & Kidd, S. P. (2022). The central role of arginine in Haemophilus influenzae survival in a polymicrobial environment with Streptococcus pneumoniae and Moraxella catarrhalis. PLOS ONE, 17(7), 1-16.
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Feliziani, C., Fernandez, M., Quassollo, G., Holstein, D., Bairo, S. M., Paton, J. C., . . . Bollo, M. (2022). Ca<sup>2+</sup> signalling system initiated by endoplasmic reticulum stress stimulates PERK activation. Cell Calcium, 106, 102622.
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Sasmal, A., Khan, N., Khedri, Z., Kellman, B. P., Srivastava, S., Verhagen, A., . . . Varki, A. (2022). Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB₅ toxin B subunits. Glycobiology, 32(12), 1101-1115.
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David, S. C., Brazel, E. B., Singleton, E. V., Minhas, V., Laan, Z., Scougall, C., . . . Alsharifi, M. (2022). A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies. mBio, 13(5), 02367-22-1-02367-22-21.
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Ricci, D., Tutton, S., Marrocco, I., Ying, M., Blumenthal, D., Eletto, D., . . . Argon, Y. (2021). An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.. J Biol Chem, 296, 1-16.
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Meijer, B. J., Smit, W. L., Koelink, P. J., Westendorp, B. F., de Boer, R. J., van der Meer, J. H. M., . . . Heijmans, J. (2021). Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2. Scientific Reports, 11(1), 9892.
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Adams, F. G., Pokhrel, A., Brazel, E. B., Semenec, L., Li, L., Trappetti, C., . . . Eijkelkamp, B. A. (2021). Acinetobacter baumannii fatty acid desaturases facilitate survival in distinct environments. ACS Infectious Diseases, 7(8), 2221-2228.
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Adams, F. G., Trappetti, C., Waters, J. K., Zang, M., Brazel, E. B., Paton, J. C., . . . Eijkelkamp, B. A. (2021). To make or take: bacterial lipid homeostasis during Infection. mBio, 12(3), e00928-21-1-e00928-21-5.
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Zang, M., MacDermott-Opeskin, H., Adams, F. G., Naidu, V., Waters, J. K., Carey, A. B., . . . Eijkelkamp, B. A. (2021). The membrane composition defines the spatial organization and function of a major Acinetobacter baumannii drug efflux system. mBio, 12(3), e01070-21-1-e01070-21-6.
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Álvarez, R. S., Gómez, F. D., Zotta, E., Paton, A. W., Paton, J. C., Ibarra, C., . . . Amaral, M. M. (2021). Combined action of shiga toxin type 2 and subtilase cytotoxin in the pathogenesis of hemolytic uremic syndrome. Toxins, 13(8), 536-1-536-16.
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Alquethamy, S. F., Adams, F. G., Maharjan, R., Delgado, N. N., Zang, M., Ganio, K., . . . Eijkelkamp, B. A. (2021). The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance. Applied and Environmental Microbiology, 87(22), e01718-21-1-e01718-21-11.
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Doultsinos, D., Carlesso, A., Chintha, C., Paton, J. C., Paton, A. W., Samali, A., . . . Eriksson, L. A. (2021). Peptidomimetic-based identification of FDA approved compounds inhibiting IRE1 activity. The FEBS Journal, 288(3), 946-960.
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McLean, K. T., Tikhomirova, A., Brazel, E. B., Legendre, S., Haasbroek, G., Minhas, V., . . . Trappetti, C. (2021). Site specific mutations of GalR affect galactose metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 203(1), 1-12.
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Tikhomirova, A., Trappetti, C., Paton, J. C., Watson-Haigh, N., Wabnitz, D., Jervis-Bardy, J., . . . Kidd, S. P. (2021). A single nucleotide polymorphism in an IgA1 protease gene determines Streptococcus pneumoniae adaptation to the middle ear during otitis media. Pathogens and Disease, 79(1), 1-8.
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Adams, F. G., Trappetti, C., Waters, J. K., Zang, M., Brazel, E. B., Paton, J. C., . . . Eijkelkamp, B. A. (2021). To make or take: bacterial lipid homeostasis during infection.
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Mendes, A., Gigan, J. P., Rodriguez Rodrigues, C., Choteau, S. A., Sanseau, D., Barros, D., . . . Pierre, P. (2021). Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. Life Science Alliance, 4(2), 1-22.
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Luo, Z., Morey, J. R., Deplazes, E., Motygullina, A., Tan, A., Ganio, K., . . . McDevitt, C. A. (2021). A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA. mBio, 12(1), 1-14.
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Minhas, V., Paton, J. C., & Trappetti, C. (2021). Sickly Sweet – How Sugar Utilization Impacts Pneumococcal Disease Progression. Trends in Microbiology, 29(9), 768-771.
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Kammann, T., Hoff, J., Yildirim, I., Shkodra, B., Müller, T., Weber, C., . . . Press, A. T. (2021). Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival.. Metabolites, 11(12), 821.
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Feliziani, C., Quasollo, G., Holstein, D., Fernandez, M., Paton, J., Paton, A., . . . Bollo, M. (2020). Endoplasmic reticulum stress induces a novel Ca2+ signalling system initiated by Ca2+ microdomains.
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Fenech, E., Lari, F., Charles, P., Fischer, R., Laétitia-Thézénas, M., Bagola, K., . . . Christianson, J. (2020). Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
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Neville, S. L., Eijkelkamp, B. A., Lothian, A., Paton, J. C., Roberts, B. R., Rosch, J. W., & McDevitt, C. A. (2020). Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae. Communications Biology, 3(1), 1-15.
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Shewell, L. K., Day, C. J., Jen, F. E. -C., Haselhorst, T., Atack, J. M., Reijneveld, J. F., . . . Jennings, M. P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6(21), eaaz4926-1-eaaz4926-14.
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Minhas, V., Aprianto, R., McAllister, L. J., Wang, H., David, S. C., McLean, K. T., . . . Trappetti, C. (2020). In vivo dual RNA-seq reveals that neutrophil recruitment underlies differential tissue tropism of Streptococcus pneumoniae. Communications biology, 3(1), 293.
DOI Scopus23 WoS16 Europe PMC19 |
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Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., . . . Christianson, J. C. (2020). Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.. Elife, 9, 29 pages.
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Brown, M., Dainty, S., Strudwick, N., Mihai, A. D., Watson, J. N., Dendooven, R., . . . Schröder, M. (2020). Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface.. Molecular biology of the cell, 31(23), 2597-2629.
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Singleton, E. V., David, S. C., Davies, J. B., Hirst, T. R., Paton, J. C., Beard, M. R., . . . Alsharifi, M. (2020). Sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses. Journal of Radiation Research, 61(6), 886-894.
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Grey, M. J., Cloots, E., Simpson, M. S., LeDuc, N., Serebrenik, Y. V., De Luca, H., . . . Lencer, W. I. (2020). IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress. The Journal of cell biology, 219(2), 17 pages.
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Andreassen, P. R., Trappetti, C., Minhas, V., Nielsen, F. D., Pakula, K., Paton, J. C., & Jørgensen, M. G. (2020). Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae. PLoS Pathog, 16(3), 1-27.
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Schorr, S., Nguyen, D., Haßdenteufel, S., Nagaraj, N., Cavalié, A., Greiner, M., . . . Zimmermann, R. (2020). Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.. The FEBS journal, 287(21), 4612-4640.
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Poothong, J., Pottekat, A., Siriin, M., Campos, A. R., Paton, A. W., Paton, J. C., . . . Kaufman, R. J. (2020). Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.. Blood, 135(21), 1899-1911.
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Alquethamy, S., Adams, F. G., Naidu, V., Khorvash, M., Pederick, V. G., Zang, M., . . . Eijkelkamp, B. A. (2020). The role of zinc efflux during Acinetobacter baumannii infection. ACS Infectious Diseases, 6(1), 150-158.
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Taverner, W. K., Jacobus, E. J., Christianson, J., Champion, B., Paton, A. W., Paton, J. C., . . . Lei-Rossmann, J. (2019). Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation. Molecular Therapy - Oncolytics, 15, 117-130.
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Álvarez, R. S., Jancic, C., Garimano, N., Sacerdoti, F., Paton, A. W., Paton, J. C., . . . Amaral, M. M. (2019). Crosstalk between Human Microvascular Endothelial Cells and Tubular Epithelial Cells Modulates Pro-Inflammatory Responses Induced by Shiga Toxin Type 2 and Subtilase Cytotoxin.. Toxins (Basel), 11(11), 648-1-648-17.
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Eijkelkamp, B. A., Morey, J. R., Neville, S. L., Tan, A., Pederick, V. G., Cole, N., . . . McDevitt, C. A. (2019). Dietary zinc and the control of Streptococcus pneumoniae infection. PLoS pathogens, 15(8), 1-26.
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Cheng, B., Dong, L., Zhu, Y., Huang, R., Sun, Y., You, Q., . . . Chen, X. (2019). 9-Azido Analogues of Three Sialic Acid Forms for Metabolic Remodeling of Cell-Surface Sialoglycans.. ACS chemical biology, 14(10), 2141-2147.
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Paton, J. C., & Trappetti, C. (2019). Stand by to repel boarders. Nature Microbiology, 4(1), 8-9.
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Oliver, E., Pope, C., Clarke, E., Langton Hewer, C., Ogunniyi, A., Paton, J., . . . Finn, A. (2019). Th17 responses to pneumococcus in blood and adenoidal cells in children. Clinical and Experimental Immunology, 195(2), 213-225.
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Minhas, V., Harvey, R. M., McAllister, L. J., Seemann, T., Syme, A. E., Paton, J. C., . . . Baines, S. L. (2019). Capacity to utilize raffinose dictates pneumococcal disease phenotype. mBio, 10(1), e02596-18-1-e02596-18-14.
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Jiang, J. H., Hassan, K. A., Begg, S. L., Rupasinghe, T. W. T., Naidu, V., Pederick, V. G., . . . Eijkelkamp, B. A. (2019). Identification of novel Acinetobacter baumannii host fatty acid stress adaptation strategies. mBio, 10(1), e02056-18-1-e02056-18-6.
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Alquethamy, S. F., Khorvash, M., Pederick, V. G., Whittall, J. J., Paton, J. C., Paulsen, I. T., . . . Eijkelkamp, B. A. (2019). The role of the copA copper efflux system in acinetobacter baumannii virulence. International Journal of Molecular Sciences, 20(3), 1-13.
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Ziska, A., Tatzelt, J., Dudek, J., Paton, A. W., Paton, J. C., Zimmermann, R., & Haßdenteufel, S. (2019). The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating. Biology Open, 8(3), 13 pages.
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Leonard, A., Grose, V., Paton, A. W., Paton, J. C., Yule, D. I., Rahman, A., & Fazal, F. (2019). Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury. Scientific Reports, 9(1), 13 pages.
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Van Krieken, R., Mehta, N., Wang, T., Zheng, M., Li, R., Gao, B., . . . Krepinsky, J. C. (2019). Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy. Journal of Biological Chemistry, 294(19), 7755-7768.
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David, S. C., Laan, Z., Minhas, V., Chen, A. Y., Davies, J., Hirst, T. R., . . . Paton, J. C. (2019). Enhanced safety and immunogenicity of a pneumococcal surface antigen A mutant whole-cell inactivated pneumococcal vaccine. Immunology and Cell Biology, 97(8), 1-14.
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David, S. C., Norton, T., Tyllis, T., Wilson, J. J., Singleton, E. V., Laan, Z., . . . Alsharifi, M. (2019). Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity. Nature Microbiology, 4(8), 1316-1327.
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Ricci, D., Marrocco, I., Blumenthal, D., Dibos, M., Eletto, D., Vargas, J., . . . Argon, Y. (2019). Clustering of IRE1α depends on sensing ER stress but not on its RNase activity. FASEB Journal, 33(9), 9811-9827.
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Arunagiri, A., Haataja, L., Pottekat, A., Pamenan, F., Kim, S., Zeltser, L. M., . . . Arvan, P. (2019). Proinsulin misfolding is an early event in the progression to type 2 diabetes. eLife, 8, 25 pages.
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Forde, B. M., McAllister, L. J., Paton, J. C., Paton, A. W., & Beatson, S. A. (2019). SMRT sequencing reveals differential patterns of methylation in two O111:H- STEC isolates from a hemolytic uremic syndrome outbreak in Australia. Scientific Reports, 9(1), 9436-1-9436-11.
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Jiang, C., Zhou, J., Shi, P., Huang, W., & Gan, D. (2019). Ultra-low frequency oscillation analysis and robust fixed order control design. INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS, 104, 269-278.
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Paton, J., & Trappetti, C. (2019). Streptococcus pneumoniae Capsular Polysaccharide. Microbiology Spectrum, 7(2), GPP3-0019- 2018-1-GPP3-0019- 2018-15.
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Ahmad, Z., Harvey, R., Paton, J., Standish, A., & Morona, R. (2018). Role of Streptococcus pneumoniae OM001 operon in capsular polysaccharide production, virulence and survival in human saliva. PLoS ONE, 13(1), 1-15.
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Sowers, C., Wang, R., Bourne, R., McGrath, B., Hu, J., Bevilacqua, S., . . . Cavener, D. (2018). The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. The Journal of biological chemistry, 293(14), 5134-5149.
DOI Scopus36 WoS27 Europe PMC32 |
| 2018 |
Tang, C. -H., Chang, S., Paton, A., Paton, J., Gabrilovich, D., Ploegh, H., . . . Hu, C. -C. (2018). Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. The Journal of cell biology, 217(5), 1739-1755.
DOI Scopus48 WoS34 Europe PMC42 |
| 2018 |
Weiser, J., Ferreira, D., & Paton, J. (2018). Streptococcus pneumoniae: transmission, colonization and invasion. Nature Reviews Microbiology, 16(6), 355-367.
DOI Scopus743 WoS413 Europe PMC613 |
| 2018 |
Poole, J., Day, C., Von Itzstein, M., Paton, J., & Jennings, M. (2018). Glycointeractions in bacterial pathogenesis. Nature Reviews Microbiology, 16(7), 440-452.
DOI Scopus185 WoS127 Europe PMC128 |
| 2018 |
Wang, J., Shewell, L., Paton, A., Paton, J., Day, C., & Jennings, M. (2018). Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin. Biochemical and biophysical research communications, 500(3), 765-771.
DOI Scopus6 WoS7 Europe PMC6 |
| 2018 |
Haßdenteufel, S., Johnson, N., Paton, A., Paton, J., High, S., & Zimmermann, R. (2018). Chaperone-mediated Sec61 channel gating during ER import of small precursor proteins overcomes Sec61 inhibitor-reinforced energy barrier. Cell Reports, 23(5), 1373-1386.
DOI Scopus67 WoS49 Europe PMC52 |
| 2018 |
Eijkelkamp, B., Begg, S., Pederick, V., Trapetti, C., Gregory, M., Whittall, J., . . . McDevitt, C. (2018). Arachidonic acid stress impacts pneumococcal fatty acid homeostasis. Frontiers in Microbiology, 9(MAY), 813-1-813-12.
DOI Scopus32 WoS23 Europe PMC29 |
| 2018 |
Luo, Z., Pederick, V. G., Paton, J. C., McDevitt, C. A., & Kobe, B. (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.. FEBS Letters, 592(13), 2341-2350.
DOI Scopus4 WoS3 Europe PMC3 |
| 2018 |
Rashwan, R., Varano della Vergiliana, J., Lansley, S., Cheah, H., Popowicz, N., Paton, J., . . . Gary Lee, Y. (2018). Streptococcus pneumoniae potently induces cell death in mesothelial cells. PLoS ONE, 13(7), e0201530-1-e0201530-15.
DOI Scopus7 WoS4 Europe PMC3 |
| 2018 |
Tikhomirova, A., Trappetti, C., Standish, A., Zhou, Y., Breen, J., Pederson, S., . . . Kidd, S. (2018). Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, small colony variant and determine the outcome of its co-culture with Haemophilus influenzae. Pathogens and disease, 76(7), 11 pages.
DOI Scopus9 WoS7 Europe PMC6 |
| 2018 |
Reglinski, M., Ercoli, G., Plumptre, C., Kay, E., Petersen, F. C., Paton, J. C., . . . Brown, J. S. (2018). A recombinant conjugated pneumococcal vaccine that protects against murine infections with a similar efficacy to Prevnar-13. NPJ vaccines, 3(1), 53.
DOI Scopus47 WoS33 Europe PMC37 |
| 2018 |
Shewell, L. K., Wang, J. J., Paton, J. C., Paton, A. W., Day, C. J., & Jennings, M. P. (2018). Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M. Biochemical and Biophysical Research Communications, 507(1-4), 173-177.
DOI Scopus22 WoS18 Europe PMC19 |
| 2018 |
Robin, M. J., Appelman, M. D., Vos, H. R., van Es, R. M., Paton, J. C., Paton, A. W., . . . van de Graaf, S. F. (2018). Calnexin depletion by endoplasmic reticulum stress during cholestasis inhibits the Na⁺-taurocholate cotransporting polypeptide. Hepatology Communications, 2(12), 1550-1566.
DOI Scopus17 WoS12 Europe PMC15 |
| 2018 |
Gómez-Fernández, P., Urtasun, A., Paton, A., Paton, J., Borrego, F., Dersh, D., . . . Vandenbroeck, K. (2018). Long interleukin-22 binding protein isoform-1 is an intracellular activator of the unfolded protein response. Frontiers in Immunology, 9, 2934-1-2934-21.
DOI Scopus11 WoS10 Europe PMC10 |
| 2017 |
Glab, J., Doerflinger, M., Nedeva, C., Jose, I., Mbogo, G., Paton, J., . . . Puthalakath, H. (2017). DR5 and caspase-8 are dispensable in ER stress-induced apoptosis. Cell Death and Differentiation, 24(5), 944-950.
DOI Scopus70 WoS61 Europe PMC51 |
| 2017 |
Day, C., Paton, A., Higgins, M., Shewell, L., Jen, F., Schulz, B., . . . Jennings, M. (2017). Structure aided design of a Neu5Gc specific lectin. Scientific Reports, 7(1), 1495-1-1495-8.
DOI Scopus17 WoS15 Europe PMC14 |
| 2017 |
Herdman, B. P., Paton, J. C., Wang, H., Beddoe, T., & Paton, A. W. (2017). Vacuolation activity and intracellular trafficking of ArtB, the binding subunit of an AB5 toxin produced by Salmonella enterica Serovar Typhi. Infection and Immunity, 85(8), e00214-17-1-e00214-17-8.
DOI Scopus5 WoS5 Europe PMC5 |
| 2017 |
Chai, M., Weiland, F., Harvey, R., Hoffmann, P., Ogunniyi, A., & Paton, J. (2017). Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis. Scientific Reports, 7(1), 2453-1-2453-11.
DOI Scopus3 WoS3 Europe PMC2 |
| 2017 |
McKenzie, D., Kara, E., Bastow, C., Tyllis, T., Fenix, K., Gregor, C., . . . McColl, S. (2017). IL-17-producing γδ T cells switch migratory patterns between resting and activated states. Nature Communications, 8(1), 15632-1-15632-13.
DOI Scopus96 WoS79 Europe PMC85 |
| 2017 |
Littler, D. R., Ang, S. Y., Moriel, D. G., Kocan, M., Kleifeld, O., Johnson, M. D., . . . Beddoe, T. T. (2017). Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.. The Journal of biological chemistry, 292(36), 15143-15158.
DOI Scopus24 WoS18 Europe PMC19 |
| 2017 |
Kim, J., Lee, H., Rhee, D., Paton, J., & Pyo, S. (2017). Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells. Biochimica et Biophysica Acta - General Subjects, 1861(11), 2663-2673.
DOI Scopus18 WoS15 Europe PMC14 |
| 2017 |
Amaral, M., Girard, M., Álvarez, R., Paton, A., Paton, J., Repetto, H., . . . Ibarra, C. (2017). Ouabain protects human renal cells against the cytotoxic effects of Shiga toxin type 2 and subtilase cytotoxin. Toxins, 9(7), 1-14.
DOI Scopus6 WoS6 Europe PMC3 |
| 2017 |
Ogunniyi, A., Khazandi, M., Stevens, A., Sims, S., Page, S., Garg, S., . . . Trott, D. (2017). Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent. PLoS ONE, 12(9), e0183457-1-e0183457-23.
DOI Scopus35 WoS33 Europe PMC27 |
| 2017 |
Popowicz, N. D., Lansley, S. M., Cheah, H. M., Kay, I. D., Carson, C. F., Waterer, G. W., . . . Lee, Y. G. (2017). Human pleural fluid is a potent growth medium for Streptococcus pneumoniae. PloS one, 12(11), 1-14.
DOI Scopus19 WoS15 Europe PMC12 |
| 2017 |
Day, C., Paton, A., Harvey, R., Hartley-Tassell, L., Seib, K., Tiralongo, J., . . . Jennings, M. (2017). Lectin activity of the pneumococcal pilin proteins. Scientific Reports, 7(1), 17784-1-17784-6.
DOI Scopus11 WoS10 Europe PMC7 |
| 2017 |
van Lidth de Jeude, J., Meijer, B., Wielenga, M., Spaan, C., Baan, B., Rosekrans, S., . . . Heijmans, J. (2017). Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells. Oncogene, 36(24), 3397-3405.
DOI Scopus29 WoS24 Europe PMC23 |
| 2017 |
Babb, R., Chen, A., Ogunniyi, A., Hirst, T., Kara, E., McColl, S., . . . Paton, J. (2017). Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine. Clinical Science, 131(2), 169-180.
DOI Scopus20 WoS15 Europe PMC12 |
| 2017 |
Cunningham, C., He, K., Arunagiri, A., Paton, A., Paton, J., Arvan, P., & Tsai, B. (2017). Chaperone-driven degradation of a misfolded proinsulin mutant in parallel with restoration of wild-type insulin secretion. Diabetes, 66(3), 741-753.
DOI Scopus31 WoS24 Europe PMC27 |
| 2017 |
Naito-Matsui, Y., Davies, L., Takematsu, H., Chou, H., Tangvoranuntakul, P., Carlin, A., . . . Varki, A. (2017). Physiological exploration of the long term evolutionary selection against expression of N-Glycolylneuraminic Acid in the Brain. Journal of Biological Chemistry, 292(7), 2557-2570.
DOI Scopus37 WoS28 Europe PMC28 |
| 2017 |
Trappetti, C., & Paton, J. C. (2017). Host-to-Host Transmission of the Pneumococcus—New Victims of a Toxic Relationship. Cell Host and Microbe, 21(1), 5-6.
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| 2017 |
Nain, M., Mukherjee, S., Karmakar, S., Paton, A., Paton, J., Abdin, M., . . . Vrati, S. (2017). GRP78 is an important host factor for Japanese encephalitis virus entry and replication in mammalian cells. Journal of Virology, 91(6), e02274-1-e02274-21.
DOI Scopus115 WoS90 Europe PMC102 |
| 2017 |
Seyahian, E. A., Oltra, G., Ochoa, F., Melendi, S., Hermes, R., Paton, J. C., . . . Zotta, E. (2017). Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21. TOXICON, 127, 49-55.
DOI WoS8 Europe PMC7 |
| 2017 |
David, S. C., Lau, J., Singleton, E. V., Babb, R., Davies, J., Hirst, T. R., . . . Alsharifi, M. (2017). The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine. Vaccine, 35(7), 1071-1079.
DOI Scopus30 WoS27 Europe PMC23 |
| 2017 |
Trappetti, C., McAllister, L., Chen, A., Wang, H., Paton, A., Oggioni, M., . . . Paton, J. (2017). Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by streptococcus pneumoniae, resulting in hypervirulence. mBio, 8(1), e02269-16-1-e02269-16-18.
DOI Scopus45 WoS33 Europe PMC33 |
| 2017 |
Hassan, K., Pederick, V., Elbourne, L., Paulsen, I., Paton, J., McDevitt, C., & Eijkelkamp, B. (2017). Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology, 17(1), 59-1-59-15.
DOI Scopus43 WoS36 Europe PMC38 |
| 2017 |
Mahdi, L., Higgins, M., Day, C., Tiralongo, J., Hartley-Tassell, L., Jennings, M., . . . Ogunniyi, A. (2017). The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates. EBioMedicine, 18, 236-243.
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Sabnis, A., Guerriero, C., Olivas, V., Sayana, A., Shue, J., Flanagan, J., . . . Bivon, T. (2016). Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America, 113(32), 9015-9020.
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Mubarak, A., Ahmed, M., Upile, N., Vaughan, C., Xie, C., Sharma, R., . . . Zhang, Q. (2016). A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans. Clinical Microbiology and Infection, 22(8), 736.e1-736.e7.
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| 2016 |
Álvarez, R., Sacerdoti, F., Jancic, C., Paton, A., Paton, J., Ibarra, C., & Amaral, M. (2016). Comparative characterization of Shiga toxin type 2 and subtilase cytotoxin effects on human renal epithelial and endothelial cells grown in monolayer and bilayer conditions. PLoS One, 11(6), e0158180-1-e0158180-14.
DOI Scopus13 WoS11 Europe PMC9 |
| 2016 |
Harvey, R., Trappetti, C., Mahdi, L., Wang, H., McAllister, L., Scalvini, A., . . . Paton, J. (2016). The variable region of pneumococcal pathogenicity island 1 is responsible for unusually high virulence of a serotype 1 isolate. Infection and Immunity, 84(3), 822-832.
DOI Scopus6 WoS6 Europe PMC5 |
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McAllister, L., Bent, S., Petty, N., Skippington, E., Beatson, S., Paton, J., & Paton, A. (2016). Genomic comparison of two O111:H¯ Enterohemorrhagic Escherichia coli isolates from a historic hemolytic-uremic syndrome outbreak in Australia. Infection and Immunity, 84(3), 775-781.
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Babb, R., Chen, A., Hirst, T., Kara, E., McColl, S., Ogunniyi, A., . . . Alsharifi, M. (2016). Intranasal vaccination with γ -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses. Clinical Science, 130(9), 697-710.
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Eijkelkamp, B., Pederick, V., Plumptre, C., Harvey, R., Hughes, C., Paton, J., & McDevitt, C. (2016). The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis in Streptococcus pneumoniae. Infection and Immunity, 84(2), 407-415.
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Kim, J., Paton, J., Briles, D., Rhee, D., & Pyo, S. (2015). Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia. Oncotarget, 6(42), 44161-44178.
DOI Scopus92 WoS81 Europe PMC70 |
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Le, N. T., Jeong, H. Y., Kwon, H. Y., Ogunniyi, A. D., Paton, J. C., Pyo, S. N., & Rhee, D. K. (2015). Erratum to Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL [Infection and Immunity, 75, 6 (2007) 2996-3005, 2007]. Infection and Immunity, 83(3), 1224.
DOI Scopus1 WoS1 Europe PMC1 |
| 2015 |
Begg, S., Eijkelkamp, B., Luo, Z., Couñago, R., Morey, J., Maher, M., . . . McDevitt, C. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6(6418), 6418-1-6418-11.
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Bajaj, M., Mamidyala, S., Zuegg, J., Begg, S., Ween, M., Luo, Z., . . . Cooper, M. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10(6), 1511-1520.
DOI Scopus19 WoS17 Europe PMC14 |
| 2015 |
Fruzangohar, M., Ebrahimie, E., Ogunniyi, A. D., Mahdi, L. K., Paton, J. C., & Adelson, D. L. (2015). Correction: Comparative GO: A web application for comparative gene ontology and gene ontology-based gene selection in bacteria. Plos One, 10(4), 1 page.
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Knippenberg, S., Ueberberg, B., Maus, R., Bohling, J., Ding, N., Tort Tarres, M., . . . Maus, U. (2015). Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax, 70(7), 636-646.
DOI Scopus88 WoS66 Europe PMC65 |
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Adomako, A., Calvo, V., Biran, N., Osman, K., Chari, A., Paton, J., . . . Aguirre-Ghiso, J. (2015). Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer, 15(1), 444-1-444-11.
DOI Scopus22 WoS19 Europe PMC15 |
| 2015 |
Paton, A., Chen, A., Wang, H., McAllister, L., Höggerl, F., Mayr, U., . . . Paton, J. (2015). Protection against Shiga-toxigenic Escherichia coli by non-genetically modified organism receptor mimic bacterial ghosts. Infection and Immunity, 83(9), 3526-3533.
DOI Scopus9 WoS13 Europe PMC4 |
| 2015 |
Chen, A., Mann, B., Gao, G., Heath, R., King, J., Maissoneuve, J., . . . Paton, J. (2015). Multivalent pneumococcal protein vaccines comprising pneumolysoid with epitopes/fragments of CbpA and/or PspA elicit strong and broad protection. Clinical and Vaccine Immunology, 22(10), 1079-1089.
DOI Scopus46 WoS33 Europe PMC37 |
| 2015 |
Pederick, V., Eijkelkamp, B., Begg, S., Ween, M., McAllister, L., Paton, J., & McDevitt, C. (2015). ZnuA and zinc homeostasis in pseudomonas aeruginosa. Scientific Reports, 5(1), 13139-1-13139-14.
DOI Scopus102 WoS86 Europe PMC90 |
| 2015 |
Deplazes, E., Begg, S., van Wonderen, J., Campbell, R., Kobe, B., Paton, J., . . . O'Mara, M. (2015). Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60.
DOI Scopus8 WoS8 Europe PMC6 |
| 2015 |
Tikhomirova, A., Trappetti, C., Paton, J., & Kidd, S. (2015). The outcome of H. influenzae and S. pneumoniae inter-species interactions depends on pH, nutrient availability and growth phase. International Journal of Medical Microbiology, 305(8), 881-892.
DOI Scopus19 WoS17 Europe PMC15 |
| 2015 |
Amin, Z., Harvey, R., Wang, H., Hughes, C., Paton, A., Paton, J., & Trappetti, C. (2015). Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15. Infection and Immunity, 83(12), 4781-4790.
DOI Scopus6 WoS6 Europe PMC4 |
| 2015 |
Wielenga, M., Colak, S., Heijmans, J., van Lidth de Jeude, J., Rodermond, H., Paton, J., . . . van den Brink, G. (2015). ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Reports, 13(3), 489-494.
DOI Scopus73 WoS62 Europe PMC57 |
| 2015 |
Barnett, T., Cole, J., Rivera-Hernandez, T., Henningham, A., Paton, J., Nizet, V., & Walker, M. (2015). Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17(12), 1721-1741.
DOI Scopus74 WoS51 Europe PMC55 |
| 2015 |
Kara, E., McKenzie, D., Bastow, C., Gregor, C., Fenix, K., Ogunniyi, A., . . . McColl, S. (2015). CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6(1), 8644-1-8644-1 7.
DOI Scopus112 WoS96 Europe PMC95 |
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Robb, M., Robb, C., Higgins, M., Hobbs, J., Paton, J., & Boraston, A. (2015). A second β-hexosaminidase encoded in the streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. The Journal of Biological Chemistry, 290(52), 30888-30900.
DOI Scopus19 WoS15 Europe PMC19 |
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Mahdi, L., Van der Hoek, M., Ebrahimie, E., Paton, J., & Ogunniyi, A. (2015). Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model. PLoS One, 10(11), e0141816-1-e0141816-15.
DOI Scopus19 WoS18 Europe PMC18 |
| 2015 |
Sun, S., Shi, G., Sha, H., Ji, Y., Han, X., Shu, X., . . . Qi, L. (2015). IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nature Cell Biology, 17(12), 1546-1555.
DOI Scopus191 WoS121 Europe PMC173 |
| 2014 |
Eijkelkamp, B., Morey, J., Ween, M., Ong, C., McEwan, A., Paton, J., & McDevitt, C. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One, 9(2), e89427-1-e89427-11.
DOI Scopus110 WoS92 Europe PMC93 |
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Counago, R., Ween, M., Begg, S., Bajaj, M., Zuegg, J., O'Mara, M., . . . McDevitt, C. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10(1), 35-43.
DOI Scopus124 WoS110 Europe PMC98 |
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Zacchi, L., Wu, H., Bell, S., Millen, L., Paton, A., Paton, J., . . . Brodsky, J. (2014). The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA⁺ ATPase associated with the neurological disease early-onset torsion dystonia. Journal of Biological Chemistry, 289(18), 12727-12747.
DOI Scopus20 WoS17 Europe PMC15 |
| 2014 |
Hostetter, S., Helgerson, A., Paton, J., Paton, A., & Cornick, N. (2014). Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome. BMC Research Notes, 7(1), 331-1-331-8.
DOI Scopus17 Europe PMC12 |
| 2014 |
Manso, A., Chai, M., Atack, J., Furi, L., Croix, M., Haigh, R., . . . Oggioni, M. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Communications, 5(1), 5055-1-5055-9.
DOI Scopus180 WoS154 Europe PMC171 |
| 2014 |
Leonard, A., Paton, A., El-Quadi, M., Paton, J., & Fazal, F. (2014). Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation. PLoS One, 9(10), e110949-1-e110949-18.
DOI Scopus37 WoS35 Europe PMC30 |
| 2014 |
Shewell, L., Harvey, R., Higgins, M., Day, C., Hartley-Tassell, L., Chen, A., . . . Jennings, M. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5312-E5320.
DOI Scopus104 WoS90 Europe PMC88 |
| 2014 |
Ng, P., Böhm, R., Hartley-Tassell, L., Steen, J., Wang, H., Lukowski, S., . . . Jennings, M. (2014). Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors. Nature Communications, 5(1), 5750-1-5750-9.
DOI Scopus92 WoS82 Europe PMC83 |
| 2014 |
Mahdi, L., Deihimi, T., Zamansani, F., Fruzangohar, M., Adelson, D., Paton, J., . . . Ebrahimie, E. (2014). A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease. BMC Genomics, 15(1), 769-1-769-15.
DOI Scopus17 WoS14 Europe PMC16 |
| 2014 |
Plumptre, C., Eijkelkamp, B., Morey, J., Behr, F., Couñago, R., Ogunniyi, A., . . . McDevitt, C. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91(4), 834-851.
DOI Scopus90 WoS80 Europe PMC80 |
| 2014 |
Wang, H., Rogers, T., Paton, J., & Paton, A. (2014). Differential effects of Escherichia coli subtilase cytotoxin and shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. Infection and Immunity, 82(9), 3567-3579.
DOI Scopus17 WoS13 Europe PMC15 |
| 2014 |
Pederick, V., Eijkelkamp, B., Ween, M., Begg, S., Paton, J., & McDevitt, C. (2014). Acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80(21), 6843-6852.
DOI Scopus33 WoS26 Europe PMC31 |
| 2014 |
Harvey, R., Hughes, C., Paton, A., Trappetti, C., Paton, J., & Tweten, R. (2014). The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. PLoS One, 9(8), e103625-1-e103625-9.
DOI Scopus31 WoS29 Europe PMC25 |
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Plumptre, C., Hughes, C., Harvey, R., Eijkelkamp, B., McDevitt, C., & Paton, J. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity, 82(10), 4315-4324.
DOI Scopus35 WoS27 Europe PMC28 |
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Hughes, C., Harvey, R., Plumptre, C., & Paton, J. (2014). Development of primary invasive pneumococcal disease caused by serotype 1 pneumococci is driven by early increased type I interferon response in the lung. Infection and Immunity, 82(9), 3919-3926.
DOI Scopus9 WoS8 Europe PMC8 |
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Potter, A., & Paton, J. (2014). Spermidine biosynthesis and transport modulate pneumococcal autolysis. Journal of Bacteriology, 196(20), 3556-3561.
DOI Scopus33 WoS25 Europe PMC29 |
| 2014 |
Lu, M., Lawrence, D., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A., . . . Ashkenazi, A. (2014). Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science, 345(6192), 98-101.
DOI Scopus480 WoS405 Europe PMC423 |
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Fucho, R., Martínez, L., Baulies, A., Torres, S., Tarrats, N., Fernandez, A., . . . García-Ruiz, C. (2014). ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. Journal of Hepatology, 61(5), 1126-1134.
DOI Scopus101 WoS77 Europe PMC82 |
| 2014 |
Marquez, L., Velazquez, N., Repetto, H., Paton, A., Paton, J., Ibarra, C., & Silberstein, C. (2014). Effects of Escherichia coli Subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells. PLoS One, 9(1), e87022-1-e87022-7.
DOI Scopus25 WoS22 Europe PMC17 |
| 2013 |
Johnson, N., Hassdenteufel, S., Theis, M., Paton, A., Paton, J., Zimmermann, R., & High, S. (2013). The signal sequence influences post-translational ER translocation at distinct stages. PLoS One, 8(10), e75394-1-e75394-11.
DOI Scopus42 WoS42 Europe PMC37 |
| 2013 |
Plumptre, C., Ogunniyi, A., & Paton, J. (2013). Vaccination against Streptococcus pneumoniae using truncated derivatives of polyhistidine triad protein D. PLoS One, 8(10), 1-11.
DOI Scopus29 WoS25 Europe PMC23 |
| 2013 |
Shak, J., Ludewick, H., Howery, K., Sakai, F., Yi, H., Harvey, R., . . . Vidal, J. (2013). Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. MBio, 4(5), 1-10.
DOI Scopus70 WoS60 Europe PMC54 |
| 2013 |
Ng, N., Littler, D., Paton, A., Le Nours, J., Rossjohn, J., Paton, J., & Beddoe, T. (2013). EcxAB is a founding member of a new family of metalloprotease AB₅ toxins with a hybrid cholera-like B subunit. Structure, 21(11), 2003-2013.
DOI Scopus21 WoS16 Europe PMC19 |
| 2013 |
Le Nours, J., Paton, A., Byres, E., Troy, S., Herdman, B., Johnson, M., . . . Beddoe, T. (2013). Structural basis of subtilase cytotoxin SubAB assembly. Journal of Biological Chemistry, 288(38), 27505-27516.
DOI Scopus19 WoS18 Europe PMC16 |
| 2013 |
Plumptre, C., Ogunniyi, A., & Paton, J. (2013). Surface association of Pht proteins of Streptococcus pneumoniae. Infection and Immunity, 81(10), 3644-3651.
DOI Scopus30 WoS24 Europe PMC22 |
| 2013 |
Mahdi, L., Ebrahimie, E., Adelson, D., Paton, J., & Ogunniyi, A. (2013). A transcription factor contributes to pathogenesis and virulence in streptococcus pneumoniae. PLoS One, 8(8), 1-9.
DOI Scopus14 WoS13 Europe PMC13 |
| 2013 |
Amaral, M., Sacerdoti, F., Jancic, C., Repetto, H., Paton, A., Paton, J., & Ibarra, C. (2013). Action of Shiga toxin type-2 and Subtilase cytotoxin on human microvascular endothelial cells. PLoS One, 8(7), 1-11.
DOI Scopus45 WoS39 Europe PMC36 |
| 2013 |
Ng, N., Littler, D., Le Nours, J., Paton, A., Paton, J., Rossjohn, J., & Beddoe, T. (2013). Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB5 toxin. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 69(8), 912-915.
DOI Scopus5 WoS5 Europe PMC5 |
| 2013 |
Gerhardt, E., Masso, M., Paton, A., Paton, J., Zotta, E., & Ibarra, C. (2013). Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21. Infection and Immunity, 81(8), 2931-2937.
DOI Scopus17 WoS16 Europe PMC16 |
| 2013 |
Heijmans, J., van Lidth de Jeude, J., Koo, B., Rosekrans, S., Wielenga, M., van de Wetering, M., . . . van den Brink, G. (2013). ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports, 3(4), 1128-1139.
DOI Scopus230 WoS195 Europe PMC213 |
| 2013 |
Fruzangohar, M., Ebrahimie, E., Ogunniyi, A., Mahdi, L., Paton, J., & Adelson, D. (2013). Comparative GO: a web application for comparative Gene Ontology and Gene Ontology-based gene selection in bacteria. PLoS One, 8(3), 1-8.
DOI Scopus59 WoS53 Europe PMC51 |
| 2013 |
Wang, H., Paton, J., Herdman, B., Rogers, T., Beddoe, T., & Paton, A. (2013). The b subunit of an AB5 toxin produced by salmonella enterica serovar typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. Infection and Immunity, 81(3), 673-683.
DOI Scopus16 WoS15 Europe PMC16 |
| 2013 |
Basavanna, S., Chimalapati, S., Maqbool, A., Rubbo, B., Yuste, J., Wilson, R., . . . Brown, J. (2013). The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence. PLoS One, 8(1), 1-14.
DOI Scopus53 WoS48 Europe PMC52 |
| 2013 |
Ong, C., Potter, A., Trappetti, C., Walker, M., Jennings, M., Paton, J., & McEwan, A. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: Role of the orphan response regulator ritR. Infection and Immunity, 81(2), 421-429.
DOI Scopus34 WoS31 Europe PMC27 |
| 2013 |
Trappetti, C., van der Maten, E., Amin, Z., Potter, A., Chen, A., van Mourik, P., . . . Paton, J. (2013). Site of isolation determines biofilm formation and virulence phenotypes of streptococcus pneumoniae serotype 3 clinical isolates. Infection and Immunity, 81(2), 505-513.
DOI Scopus20 WoS19 Europe PMC14 |
| 2012 |
Eletto, D., Maganty, A., Eletto, D., Dersh, D., Makarewich, C., Biswas, C., . . . Argon, Y. (2012). Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of Cell Science, 125(20), 4865-4875.
DOI Scopus34 WoS30 Europe PMC31 |
| 2012 |
Potter, A., Trappetti, C., & Paton, J. (2012). Streptococcus pneumoniae uses glutathione to defend against oxidative stress and metal ion toxicity. Journal of Bacteriology, 194(22), 6248-6254.
DOI Scopus99 WoS73 Europe PMC78 |
| 2012 |
Brumshagen, C., Maus, R., Bischof, A., Ueberberg, B., Bohling, J., Osterholzer, J., . . . Maus, U. (2012). FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: Role of pneumolysin. Infection and Immunity, 80(12), 4281-4290.
DOI Scopus19 WoS17 Europe PMC15 |
| 2012 |
Johno, H., Nakajima, S., Kato, H., Yao, J., Paton, A., Paton, J., . . . Kitamura, M. (2012). Unfolded protein response causes a phenotypic shift of inflamed glomerular cells toward redifferentiation through dual blockade of Akt and Smad signaling pathways. American Journal of Pathology, 181(6), 1977-1990.
DOI Scopus5 WoS5 Europe PMC4 |
| 2012 |
Plumptre, C., Ogunniyi, A., & Paton, J. (2012). Polyhistidine triad proteins of pathogenic streptococci. Trends in Microbiology, 20(10), 485-493.
DOI Scopus48 WoS42 Europe PMC43 |
| 2012 |
Ray, R., de Ridder, G., Eu, J., Paton, A., Paton, J., & Pizzo, S. (2012). The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. Journal of Biological Chemistry, 287(39), 32755-32769.
DOI Scopus20 WoS17 Europe PMC15 |
| 2012 |
Athanasiou, D., Kosmaoglou, M., Kanuga, N., Novoselov, S., Paton, A., Paton, J., . . . Cheetham, M. (2012). BiP prevents rod opsin aggregation. Molecular Biology of the Cell, 23(18), 3522-3531.
DOI Scopus42 WoS40 Europe PMC39 |
| 2012 |
Watts, R., Tan, C., Ulett, G., Carey, A., Totsika, M., Idris, A., . . . Schembri, M. (2012). Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli. Journal of Infectious Diseases, 206(8), 1242-1249.
DOI Scopus26 WoS18 Europe PMC16 |
| 2012 |
Ogunniyi, A., Mahdi, L., Trappetti, C., Verhoeven, N., Mermans, D., Van der Hoek, M., . . . Paton, J. (2012). Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by in vivo transcriptomic analysis. Infection and Immunity, 80(9), 3268-3278.
DOI Scopus55 WoS47 Europe PMC48 |
| 2012 |
Schauble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulucan, O., . . . Zimmerman, R. (2012). BiP-mediated closing of the Sec61 channel limits Ca²⁺ leakage from the ER. EMBO Journal, 31(15), 3282-3296.
DOI Scopus140 WoS119 Europe PMC127 |
| 2012 |
Rogers, T., Thorpe, C., Paton, A., & Paton, J. (2012). Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga-toxigenic Escherichia coli O113:H21. Infection and Immunity, 80(8), 2858-2867.
DOI Scopus35 WoS30 Europe PMC32 |
| 2012 |
Paton, A., Morona, R., & Paton, J. (2012). Bioengineered microbes in disease therapy. Trends in Molecular Medicine, 18(7), 417-425.
DOI Scopus40 WoS29 Europe PMC28 |
| 2012 |
Mahdi, L., Wang, H., Van der Hoek, M., Paton, J., & Ogunniyi, A. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. Journal of Clinical Investigation, 122(6), 2208-2220.
DOI Scopus45 WoS39 Europe PMC42 |
| 2012 |
Weber, M., Lambeck, S., Ding, N., Henken, S., Kohl, M., Deigner, H., . . . Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB Journal, 26(6), 2424-2436.
DOI Scopus36 WoS33 Europe PMC27 |
| 2012 |
McAllister, L., Ogunniyi, A., Stroeher, U., & Paton, J. (2012). Contribution of a genomic accessory region encoding a putative cellobiose phosphotransferase system to virulence of Streptococcus Pneumoniae. PLoS One, 7(2), 1-9.
DOI Scopus20 WoS19 Europe PMC17 |
| 2012 |
Schäsignuble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulucan, O., . . . Zimmermann, R. (2012). Erratum: BiP-mediated closing of the Sec61 channel limits Ca 2+ leakage from the ER (The EMBO Journal (2012) 31 (3282-3296) DOI: 10.1038/emboj.2012.189). EMBO Journal, 31(18), 3784.
DOI WoS1 |
| 2012 |
Jalali, S., & Dousti, M. (2012). Vocabulary and Grammar Gain Through Computer Educational Games. GEMA ONLINE JOURNAL OF LANGUAGE STUDIES, 12(4), 1077-1088. |
| 2011 |
Hahn, I., Klaus, A., Steinwede, K., Ding, N., Bohling, J., Serrano, H., . . . Maus, U. (2011). Cathepsin G And Neutrophil Elastase Play Critical And Non-Redundant Roles In Lung Protective Immunity Against Streptococcus Pneumoniae In Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 1 page. |
| 2011 |
Harvey, R., Stroeher, U., Ogunniyi, A., Smith-Vaughan, H., Leach, A., & Paton, J. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One, 6(5), 1-14.
DOI Scopus41 WoS35 Europe PMC37 |
| 2011 |
Paton, J. C., & Ogunniyi, A. D. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host and Microbe, 9(2), 89-91.
DOI Scopus2 WoS2 Europe PMC1 |
| 2011 |
Hahn, I., Klaus, A., Janze, A., Steinwede, K., Ding, N., Bohling, J., . . . Maus, U. (2011). Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective Immunity against Streptococcus pneumoniae in mice. Infection and Immunity, 79(12), 4893-4901.
DOI Scopus83 WoS72 Europe PMC79 |
| 2011 |
Steinwede, K., Tempelhof, O., Bolte, K., Maus, R., Bohling, J., Ueberberg, B., . . . Maus, U. (2011). Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. Journal of Immunology, 187(10), 5346-5356.
DOI Scopus72 WoS66 Europe PMC58 |
| 2011 |
McAllister, L., Ogunniyi, A., Stroeher, U., Leach, A., & Paton, J. (2011). Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infection and Immunity, 79(12), 4839-4849.
DOI Scopus25 WoS23 Europe PMC23 |
| 2011 |
McDevitt, C., Ogunniyi, A., Valkov, E., Lawrence, M., Kobe, B., McEwan, A., & Paton, J. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7(11), 2357-2365.
DOI Scopus343 WoS287 Europe PMC277 |
| 2011 |
Trappetti, C., Potter, A., Paton, A., Oggioni, M., & Paton, J. (2011). LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae. Infection and Immunity, 79(11), 4550-4558.
DOI Scopus98 WoS84 Europe PMC77 |
| 2011 |
Harvey, R., Ogunniyi, A., Chen, A., & Paton, J. (2011). Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood. Infection and Immunity, 79(10), 4122-4130.
DOI Scopus40 WoS37 Europe PMC32 |
| 2011 |
Zhang, H., Zhao, Y., Tian, T., Paton, A., Paton, J., & Kitamura, M. (2011). Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress. Analytical Biochemistry, 417(2), 292-294.
DOI Scopus2 WoS5 Europe PMC2 |
| 2011 |
Coats, M., Murphy, T., Paton, J., Gray, B., & Briles, D. (2011). Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A. Microbial Pathogenesis, 50(6), 343-349.
DOI Scopus50 WoS41 Europe PMC36 |
| 2011 |
Tian, T., Zhao, Y., Nakajima, S., Huang, T., Yao, J., Paton, A., . . . Kitamura, M. (2011). Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochemical and Biophysical Research Communications, 410(4), 852-858.
DOI Scopus14 WoS15 Europe PMC14 |
| 2011 |
Nakajima, S., Hiramatsu, N., Hayakawa, K., Saito, Y., Kato, H., Huang, T., . . . Kitamura, M. (2011). Selective abrogation of BiP/GRP78 blunts activation of NF-κΒ through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt. Molecular and Cellular Biology, 31(8), 1710-1718.
DOI Scopus105 WoS85 Europe PMC94 |
| 2011 |
Goodwin, E., Lipovsky, A., Inoue, T., Magaldi, T., Edwards, A., Van Goor, K., . . . DiMaio, D. (2011). BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio, 2(3), e00101-1-e00101-9.
DOI Scopus92 WoS85 Europe PMC84 |
| 2011 |
van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J., Higgins, M., Deng, L., . . . Boraston, A. (2011). The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure, 19(5), 640-651.
DOI Scopus46 WoS39 Europe PMC31 |
| 2011 |
Zhao, Y., Tian, T., Huang, T., Nakajima, S., Saito, Y., Takahashi, S., . . . Kitamura, M. (2011). Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response. Toxicological Sciences, 120(1), 79-86.
DOI Scopus13 WoS13 Europe PMC9 |
| 2011 |
Trappetti, C., Ogunniyi, A., Oggioni, M., & Paton, J. (2011). Extracellular matrix formation enhances the ability of streptococcus pneumoniae to cause invasive disease. PLoS One, 6(5), 1-17.
DOI Scopus57 WoS48 Europe PMC48 |
| 2011 |
Byrne, J., Morona, J., Paton, J., & Morona, R. (2011). Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation. Journal of Bacteriology, 193(9), 2341-2346.
DOI Scopus18 WoS14 Europe PMC13 |
| 2011 |
Wang, H., Paton, A., McColl, S., & Paton, J. (2011). In vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin. Infection and Immunity, 79(4), 1671-1679.
DOI Scopus14 WoS13 Europe PMC10 |
| 2010 |
Paton, A., & Paton, J. (2010). Escherichia coli subtilase cytotoxin. Toxins, 2(2), 215-228.
DOI Scopus45 WoS44 Europe PMC36 |
| 2010 |
Paton, A., Morona, R., & Paton, J. (2010). Bioengineered bugs expressing oligosaccharide receptor mimics: Toxin-binding probiotics for treatment and prevention of enteric infections. Bioengineered Bugs, 1(3), 172-177.
DOI Scopus27 Europe PMC15 |
| 2010 |
May, K., Paton, J., & Paton, A. (2010). Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak. Infection and Immunity, 78(11), 4691-4696.
DOI Scopus27 WoS23 Europe PMC21 |
| 2010 |
Wang, H., Paton, J., Thorpe, C., Bonder, C., Sun, W., & Paton, A. (2010). Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli. Journal of Infectious Diseases, 202(9), 1415-1423.
DOI Scopus12 WoS9 Europe PMC8 |
| 2010 |
Martin, S., Hill, D., Paton, J., Paton, A., Birch-Machin, M., Lovat, P., & Redfern, C. (2010). Targeting GRP78 to enhance melanoma cell death. Pigment Cell & Melanoma Research, 23(5), 675-682.
DOI Scopus41 WoS34 Europe PMC30 |
| 2010 |
Ogunniyi, A., Mahdi, L., Jennings, M., McEwan, A., McDevitt, C., Van der Hoek, M., . . . Paton, J. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192(17), 4489-4497.
DOI Scopus87 WoS77 Europe PMC74 |
| 2010 |
Henken, S., Bohling, J., Ogunniyi, A., Paton, J., Salisbury, V., Welte, T., & Maus, U. (2010). Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumoniae serotypes. Antimicrobial Agents and Chemotherapy, 54(8), 3155-3160.
DOI Scopus22 WoS19 Europe PMC17 |
| 2010 |
Potter, A., Kidd, S., McEwan, A., & Paton, J. (2010). The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production. Journal of Bacteriology, 192(15), 4063-4066.
DOI Scopus25 WoS19 Europe PMC18 |
| 2010 |
Henken, S., Bohling, J., Martens-Lobenhoffer, J., Paton, J., Ogunniyi, A., Briles, D., . . . Maus, U. (2010). Efficacy profiles of Daptomycin for treatment of Iinvasive and noninvasive pulmonary infections with treptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 54(2), 707-717.
DOI Scopus32 WoS29 Europe PMC26 |
| 2010 |
Jandhyala, D., Rogers, T., Kane, A., Paton, A., Paton, J., & Thorpe, C. (2010). Shiga toxin 2 and Flagellin from Shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation. Infection and Immunity, 78(7), 2984-2994.
DOI Scopus26 WoS24 Europe PMC24 |
| 2010 |
Paton, A., Morona, R., & Paton, J. (2010). Receptor-mimic probiotics: Potential therapeutics for bacterial toxin-mediated enteric diseases. Expert Review of Gastroenterology and Hepatology, 4(3), 253-255.
DOI Scopus4 WoS6 Europe PMC1 |
| 2010 |
Nakajima, S., Saito, Y., Takahashi, S., Hiramatsu, N., Kato, H., Johno, H., . . . Kitamura, M. (2010). Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response. Biochemical and Biophysical Research Communications, 397(2), 176-180.
DOI Scopus13 WoS13 Europe PMC14 |
| 2010 |
Herbold, W., Maus, R., Hahn, I., Ding, N., Srivastava, M., Christman, J., . . . Maus, U. (2010). Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infection and Immunity, 78(6), 2620-2630.
DOI Scopus91 WoS82 Europe PMC74 |
| 2010 |
Zhang, Q., Bagrade, L., Clarke, E., Paton, J., Nunez, D., & Finn, A. (2010). Bacterial lipoproteins differentially regulate human primary and memory CD4+T and B cell responses to pneumococcal protein antigens through Toll-like receptor 2. Journal of Infectious Diseases, 201(11), 1753-1763.
DOI Scopus19 WoS17 Europe PMC16 |
| 2010 |
Beddoe, T., Paton, A., Le Nours, J., Rossjohn, J., & Paton, J. (2010). Structure, biological functions and applications of the AB5 toxins. Trends in Biochemical Sciences, 35(7), 411-418.
DOI Scopus213 WoS180 Europe PMC160 |
| 2010 |
Teare, H., Robins, E. G., Kirjavainen, A., Forsback, S., Sandford, G., Solin, O., . . . Gouverneur, V. (2010). Radiosynthesis and evaluation of [18F]Selectfluor bis(triflate). Angewandte Chemie International Edition, 49(38), 6821-6824.
DOI Scopus127 Europe PMC63 |
| 2009 |
Herold, S., Paton, J., Srimanote, P., & Paton, A. (2009). Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli. Microbiology, 155(11), 3554-3563.
DOI Scopus37 WoS28 Europe PMC22 |
| 2009 |
Rogers, T., & Paton, A. (2009). Therapeutic strategies for Shiga toxin-producing Escherichia coli infections. Expert Review of Anti-infective Therapy, 7(6), 683-686.
DOI Scopus9 Europe PMC7 |
| 2009 |
Backer, J., Krivoshein, A., Hamby, C., Pizzonia, J., Gilbert, K., Ray, Y., . . . Backer, M. (2009). Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. Neoplasia, 11(11), 1165-1173.
DOI Scopus50 WoS47 Europe PMC47 |
| 2009 |
Buchkovich, N., Maguire, T., Paton, A., Paton, J., & Alwine, J. (2009). The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. Journal of Virology, 83(22), 11421-11428.
DOI Scopus68 WoS66 Europe PMC65 |
| 2009 |
Hu, C., Dougan, S., Winter, S., Paton, A., Paton, J., & Ploegh, H. (2009). Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. Journal of Experimental Medicine, 206(11), 2429-2440.
DOI Scopus32 WoS28 Europe PMC29 |
| 2009 |
Smith, R., Willett, R., Kudlyk, T., Pokrovskaya, I., Paton, A., Paton, J., & Lupashin, V. (2009). The COG complex, Rab6 and COPI define a novel golgi retrograde trafficking pathway that is exploited by SubAB toxin. Traffic, 10(10), 1502-1517.
DOI Scopus66 WoS46 Europe PMC62 |
| 2009 |
Martner, A., Skovbjerg, S., Paton, J., & Wold, A. (2009). Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte-activating cytokines. Infection and Immunity, 77(9), 3826-3837.
DOI Scopus55 WoS51 Europe PMC49 |
| 2009 |
Huang, T., Wan, Y., Zhu, Y., Fang, X., Hiramatsu, N., Hayakawa, K., . . . Yao, J. (2009). Downregulation of Gap Junction Expression and Function by Endoplasmic Reticulum Stress. Journal of Cellular Biochemistry, 107(5), 973-983.
DOI Scopus21 WoS22 Europe PMC20 |
| 2009 |
Herold, S., Paton, J., & Paton, A. (2009). Sab, a novel autotransporter of locus of enterocyte effacement-negative shiga-toxigenic escherichia coli O113:H21, Contributes to adherence and biofilm formation. Infection and Immunity, 77(8), 3234-3243.
DOI Scopus66 WoS64 Europe PMC57 |
| 2009 |
Yamazaki, H., Hiramatsu, K., Hayakawa, K., Tagawa, Y., Okamura, M., Ogata, R., . . . Kitamura, M. (2009). Activation of the Akt-NF-kappa B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response. Journal of Immunology, 183(2), 1480-1487.
DOI Scopus252 WoS209 Europe PMC201 |
| 2009 |
Harama, D., Koyama, K., Mukai, M., Shimokawa, N., Miyata, M., Nakamura, Y., . . . Nakao, A. (2009). A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. Journal of Immunology, 183(2), 1368-1374.
DOI Scopus38 WoS35 Europe PMC37 |
| 2009 |
Lofling, J., Paton, A., Varki, N., Paton, J., & Varki, A. (2009). A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome. Kidney International, 76(2), 140-144.
DOI Scopus34 WoS25 Europe PMC21 |
| 2009 |
Du, S., Hiramatsu, N., Hayakawa, K., Kasai, A., Okamura, M., Huang, T., . . . Kitamura, M. (2009). Suppression of NF-kappa B by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response. Journal of Immunology, 182(11), 7201-7211.
DOI Scopus82 WoS77 Europe PMC67 |
| 2009 |
Winter, C., Herbold, W., Maus, R., Langer, F., Briles, D., Paton, J., . . . Maus, U. (2009). Important Role for CC Chemokine Ligand 2-Dependent Lung Mononuclear Phagocyte Recruitment to Inhibit Sepsis in Mice Infected with Streptococcus pneumoniae. Journal of Immunology, 182(8), 4931-4937.
DOI Scopus68 WoS61 Europe PMC54 |
| 2009 |
Arevalo, M., Xu, Q., Paton, J., Hollingshead, S., Pichichero, M., Briles, D., . . . Zeng, M. (2009). Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung. FEMS Immunology and Medical Microbiology, 55(3), 346-351.
DOI Scopus29 WoS25 Europe PMC22 |
| 2009 |
Newton, H., Sloan, J., Bulach, D., Seemann, T., Allison, C., Tauschek, M., . . . Hartland, E. (2009). Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement. Emerging Infectious Diseases, 15(3), 372-380.
DOI Scopus106 WoS100 Europe PMC86 |
| 2009 |
Hayakawa, K., Hiramatsu, N., Okamura, M., Yamazaki, H., Nakajima, S., Yao, J., . . . Kitamura, M. (2009). Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation. Journal of Immunology, 182(2), 1182-1191.
DOI Scopus56 WoS51 Europe PMC48 |
| 2009 |
Ogunniyi, A., Grabowicz, M., Mahdi, L., Cook, J., Gordon, D., Sadlon, T., & Paton, J. (2009). Pneumococcal histidine triad proteins are regulated by the Zn²⁺-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H. FASEB Journal, 2008(3), 1-8.
DOI Scopus111 WoS97 Europe PMC92 |
| 2008 |
Chen, Q., Cannons, J., Paton, J., Akiba, H., Schwartzberg, P., & Snapper, C. (2008). A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine. Journal of Immunology, 181(12), 8258-8266.
DOI Scopus27 WoS26 Europe PMC25 |
| 2008 |
Bernatoniene, J., Zhang, Q., Dogan, S., Mitchell, T., Paton, J., & Finn, A. (2008). Induction of CC and CXC chemokines in human antigen‐presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by Toll‐Like receptor 4, NF‐κB, and mitogen‐activated protein kinases. Journal of Infectious Diseases, 198(12), 1823-1833.
DOI Scopus37 WoS35 Europe PMC34 |
| 2008 |
Byres, E., Paton, A., Paton, J., Lofling, J., Smith, D., Wilce, M., . . . Beddoe, T. (2008). Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature, 456(7222), 648-652.
DOI Scopus201 WoS176 Europe PMC170 |
| 2008 |
Okamura, M., Takano, Y., Hiramatsu, N., Hayakawa, K., Yao, J., Paton, A., . . . Kitamura, M. (2008). Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response. American Journal of Physiology - Renal Physiology, 295(5), F1495-F1503.
DOI Scopus42 WoS38 Europe PMC38 |
| 2008 |
Lass, A., Kujawa, M., McConnell, E., Paton, A., Paton, J., & Wojcik, C. (2008). Decreased ER-associated degradation of alpha-TCR induced by Grp78 depletion with the SubAB cytotoxin. International Journal of Biochemistry & Cell Biology, 40(12), 2865-2879.
DOI Scopus23 WoS23 Europe PMC21 |
| 2008 |
Ogunniyi, A., Paton, J., Kirby, A., McCullers, J., Cook, J., Hyodo, M., . . . Karaolis, D. (2008). C-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine, 26(36), 4676-4685.
DOI Scopus79 WoS61 Europe PMC56 |
| 2008 |
Martner, A., Dahlgren, C., Paton, J., & Wold, A. (2008). Pneumolysin released during Streptococcus pneumoniae autolysis is a potent activator of intracellular oxygen radical production in neutrophils. Infection and Immunity, 76(9), 4079-4087.
DOI Scopus89 WoS81 Europe PMC79 |
| 2008 |
Wolfson, J., May, K., Thorpe, C., Jandhyala, D., Paton, J., & Paton, A. (2008). Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways. Cellular Microbiology, 10(9), 1775-1786.
DOI Scopus134 WoS119 Europe PMC112 |
| 2008 |
Takano, S., Ando, T., Hiramatsu, N., Kanayama, A., Maekawa, S., Ohnuma, Y., . . . Nakao, A. (2008). T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochemical and Biophysical Research Communications, 371(4), 762-766.
DOI Scopus16 WoS14 Europe PMC11 |
| 2008 |
Kadioglu, A., Weiser, J., Paton, J., & Andrew, P. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Reviews. Microbiology, 6(4), 288-301.
DOI Scopus936 WoS801 Europe PMC762 |
| 2008 |
Dessing, M., Florquin, S., Paton, J., & van der Poll, T. (2008). Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci. Cellular Microbiology, 10(1), 237-246.
DOI Scopus59 WoS55 Europe PMC52 |
| 2008 |
Mahdi, L., Ogunniyi, A., Le Messurier, K., & Paton, J. (2008). Pneumococcal Virulence Gene Expression and Host Cytokine Profiles during Pathogenesis of Invasive Disease. Infection and Immunity, 76(2), 646-657.
DOI Scopus54 WoS49 Europe PMC52 |
| 2008 |
Chong, D., Paton, J., Thorpe, C., & Paton, A. (2008). Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB(5) toxin that targets the endoplasmic reticulum chaperone BiP. Cellular Microbiology, 10(3), 795-806.
DOI Scopus54 WoS50 Europe PMC50 |
| 2008 |
Taut, K., Winter, C., Briles, D., Paton, J., Christman, J., Maus, R., . . . Maus, U. (2008). Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae. American Journal of Respiratory Cell and Molecular Biology, 38(1), 105-113.
DOI Scopus67 WoS63 Europe PMC61 |
| 2008 |
Buchkovich, N., Maguire, T., Yu, Y., Paton, A., Paton, J., & Alwine, J. (2008). Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. Journal of Virology, 82(1), 31-39.
DOI Scopus86 WoS74 Europe PMC77 |
| 2008 |
Hayakawa, K., Hiramatsu, N., Okamura, M., Yao, J., Paton, A., Paton, J., & Kitamura, M. (2008). Blunted activation of NF-kappa B and NF-kappa B-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response. Biochemical and Biophysical Research Communications, 365(1), 47-53.
DOI Scopus29 WoS29 Europe PMC25 |
| 2008 |
Chen, Q., Akiba, H., Paton, J. C., Cannons, J., Schwartzberg, P. L., & Snapper, C. (2008). The CD4+T cell- and SAP-dependent IgG anti-polysaccharide response to intact Streptococcus pneumoniae, in contrast to pneumococcal conjugate vaccine, is ICOS-independent. FASEB JOURNAL, 22, 1 page. |
| 2007 |
Standish, A., Stroeher, U., & Paton, J. (2007). The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. Journal of Bacteriology, 189(15), 5591-5600.
DOI Scopus20 WoS15 Europe PMC15 |
| 2007 |
Tu, L., Jeong, H., Kwon, H., Ogunniyi, A., Paton, J., Pyo, S., & Rhee, D. (2007). Modulation of adherence invasion and tumor necrosis factor alpha secretion during the early stages of infection by Strepococcus pneumoniae ClpL. Infection and Immunity, 75(6), 2996-3005.
DOI Scopus28 WoS18 Europe PMC23 |
| 2007 |
Winter, C., Taut, K., Srivastava, M., Langer, F., Mack, M., Briles, D., . . . Maus, U. (2007). Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host Defense to Streptococcus pneumoniae infection in mice: Role of the CCL2-CCR2 axis. Journal of Immunology, 178(9), 5828-5838.
DOI Scopus86 WoS83 Europe PMC79 |
| 2007 |
Maus, U., Backi, M., Winter, C., Srivastava, M., Schwarz, M., Ruckle, T., . . . Preissner, K. (2007). Importance of phosphoinositide 3-kinase γ in the host defense against pneumococcal infection. American Journal of Respiratory and Critical Care Medicine, 175(9), 958-966.
DOI Scopus69 WoS63 Europe PMC56 |
| 2007 |
Zhang, Q., Bagrade, L., Bernatoniene, J., Clarke, E., Paton, J., Mitchell, T., . . . Finn, A. (2007). Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. Journal of Infectious Diseases, 195(8), 1194-1202.
DOI Scopus81 WoS73 Europe PMC57 |
| 2007 |
Ogunniyi, A., Le Messurier, K., Graham, R., Watt, J., Briles, D., Stroeher, U., & Paton, J. (2007). Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model. Infection and Immunity, 75(4), 1843-1851.
DOI Scopus85 WoS73 Europe PMC66 |
| 2007 |
Ogunniyi, A., Grabowicz, M., Briles, D., Cook, J., & Paton, J. (2007). Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infection and Immunity, 75(1), 350-357.
DOI Scopus170 WoS150 Europe PMC140 |
| 2007 |
Takano, Y., Hiramatsu, N., Okamura, M., Hayakawa, K., Shimada, T., Kasai, A., . . . Kitamura, M. (2007). Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response. Biochemical and Biophysical Research Communications, 360(2), 470-475.
DOI Scopus29 WoS30 Europe PMC26 |
| 2007 |
Stroeher, U., Kidd, S., Stafford, S., Jennings, M., Paton, J., & McEwan, A. (2007). A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. Journal of Infectious Diseases, 196(12), 1820-1826.
DOI Scopus48 WoS45 Europe PMC39 |
| 2007 |
Pramanik, A., Stroeher, U., Krejci, J., Standish, A., Bohn, E., Paton, J., . . . Braun, V. (2007). Albomycin is an effective antibiotic, as exemplified with Yersinia enterocolitica and Streptococcus pneumoniae. International Journal of Medical Microbiology, 297(6), 459-469.
DOI Scopus68 WoS54 Europe PMC44 |
| 2007 |
Wang, H., Paton, J., & Paton, A. (2007). Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB₅ toxin that targets the endoplasmic reticulum. Journal of Infectious Diseases, 196(7), 1093-1101.
DOI Scopus82 WoS74 Europe PMC64 |
| 2007 |
Winter, C., Taut, K., Langer, F., Mack, M., Briles, D., Paton, J., . . . Maus, U. (2007). FMS-Like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: Role of dendritic cells. Journal of Immunology, 179(5), 3099-3108.
DOI Scopus33 WoS31 Europe PMC29 |
| 2006 |
Paton, A., Morona, R., & Paton, J. (2006). Treatment and Prevention of Enteric Infections With Toxin-binding Probiotics. Discovery Medicine, 6(31), 35-39.
Scopus1 |
| 2006 |
Zhang, Q., Bernatoniene, J., Bagrade, L., Pollard, A., Mitchell, T., Paton, J., & Finn, A. (2006). Serum and mucosal antibody respnses to pneumococcal protein antigens in children: relationships with carriage status. European Journal of Immunology, 36(1), 46-57.
DOI Scopus91 WoS81 Europe PMC68 |
| 2006 |
Paton, J., & Paton, A. (2006). Shiga toxin 'goes retro' in human primary kidney cells. Kidney International, 70(12), 2049-2051.
DOI Scopus13 WoS12 Europe PMC8 |
| 2006 |
Graham, R., & Paton, J. (2006). Differential role of CbpA and PspA in modulation of in vitro CXC chemokine responses of respiratory epithelial cells to infection with Streptococcus pneumoniae. Infection and Immunity, 74(12), 6739-6749.
DOI Scopus15 WoS15 Europe PMC14 |
| 2006 |
Paton, A., Beddoe, T., Thorpe, C., Whisstock, J., Wilce, M., Rossjohn, J., . . . Paton, J. (2006). AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature, 443(7111), 548-552.
DOI Scopus324 WoS288 Europe PMC284 |
| 2006 |
Zhang, Q., Bernatoniene, J., Bagrade, L., Paton, J., Mitchell, T., Hammerschmidt, S., . . . Finn, A. (2006). Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infection and Immunity, 74(8), 4735-4743.
DOI Scopus41 WoS39 Europe PMC33 |
| 2006 |
Manco, S., Hernon, F., Yesilkaya, H., Paton, J., Andrew, P., & Kadioglu, A. (2006). Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. Infection and Immunity, 74(7), 4014-4020.
DOI Scopus161 WoS141 Europe PMC131 |
| 2006 |
Morona, J., Morona, R., & Paton, J. (2006). Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. Proceedings of the National Academy of Sciences of the United States of America, 103(22), 8505-8510.
DOI Scopus114 WoS98 Europe PMC87 |
| 2006 |
Focareta, A., Paton, J., Morona, R., Cook, J., & Paton, A. (2006). A recombinant probiotic for treatment and prevention of cholera. Gastroenterology, 130(6), 1688-1695.
DOI Scopus84 WoS67 Europe PMC61 |
| 2006 |
Rogers, T., Paton, J., Wang, H., Talbot, U., & Paton, A. (2006). Reduced virulence of an fliC mutant of Shiga-Toxigenic Escherichia coli O113 : H21. Infection and Immunity, 74(3), 1962-1966.
DOI Scopus19 WoS17 Europe PMC19 |
| 2006 |
Le Messurier, K., Ogunniyi, A., & Paton, J. (2006). Differential expression of key pneumococcal virulence genes in vivo. Microbiology, 152(2), 305-311.
DOI Scopus94 WoS84 Europe PMC76 |
| 2006 |
Paton, A., Morona, R., & Paton, J. (2006). Designer probiotics for prevention of enteric infections. Nature Reviews. Microbiology, 4(3), 193-200.
DOI Scopus101 WoS79 Europe PMC58 |
| 2005 |
Paton, A., Jennings, M., Morona, R., Wang, H., Focareta, A., Roddam, L., & Paton, J. (2005). Recombinant probiotics for treatment and prevention of enterotoxigenic escherichia coli diarrhea. Gastroenterology, 128(5), 1219-1228.
DOI Scopus90 WoS74 Europe PMC63 |
| 2005 |
Srivastava, A., Henneke, P., Visintin, A., Morse, S., Martin, V., Watkins, C., . . . Malley, R. (2005). The apoptotic response to pneumolysin is toll-like receptor 4 dependent and protects against pneumococcal disease. Infection and Immunity, 73(10), 6479-6487.
DOI Scopus152 WoS133 Europe PMC118 |
| 2005 |
Jomaa, M., Yuste, J., Paton, J., Jones, C., Dougan, G., & Brown, J. (2005). Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae. Infection and Immunity, 73(10), 6852-6859.
DOI Scopus77 WoS69 Europe PMC66 |
| 2005 |
Yuste, J., Botto, M., Paton, J., Holden, D., & Brown, J. (2005). Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. Journal of Immunology, 175(3), 1813-1819.
DOI Scopus83 WoS70 Europe PMC71 |
| 2005 |
Talbot, U., Paton, J., & Paton, A. (2005). Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli. Infection and Immunity, 73(7), 4432-4436.
DOI Scopus26 WoS26 Europe PMC25 |
| 2005 |
Paton, A., & Paton, J. (2005). Multiplex PCR for direct detection of Shiga toxigenic Escherichia coli strains producing the novel subtilase cytotoxin. Journal of Clinical Microbiology, 43(6), 2944-2947.
DOI Scopus90 WoS90 Europe PMC73 |
| 2005 |
Standish, A., Stroeher, U., & Paton, J. (2005). The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumonia. Proceedings of the National Academy of Sciences of the United States of America, 102(21), 7701-7706.
DOI Scopus41 WoS36 Europe PMC34 |
| 2005 |
Palaniappan, R., Singh, S., Singh, U., Sakthivel, S., Ades, E., Briles, D., . . . Lillard Jr., J. (2005). Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infection and Immunity, 73(2), 1006-1013.
DOI Scopus41 WoS38 Europe PMC31 |
| 2005 |
Khan, A., Chen, Q., Wu, Z., Paton, J., & Snapper, C. (2005). Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2. Infection and Immunity, 73(1), 298-307.
DOI Scopus85 WoS81 Europe PMC71 |
| 2004 |
Kwon, H., Ogunniyi, A., Choi, M., Pyo, S., Rhee, D., & Paton, J. (2004). The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Infection and Immunity, 72(10), 5646-5653.
DOI Scopus96 WoS90 Europe PMC80 |
| 2004 |
McAllister, L., Tseng, H., Ogunniyi, A., Jennings, M., McEwan, A., & Paton, J. (2004). Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Molecular Microbiology, 53(3), 889-901.
DOI Scopus124 WoS111 Europe PMC104 |
| 2004 |
Paton, A., Srimanote, P., Talbot, U., Wang, H., & Paton, J. (2004). A new family of potent AB5 cytotoxins produced by Shiga toxigenic Escherichia coli.. Journal of Experimental Medicine, 200(1), 35-46.
DOI Scopus284 WoS256 Europe PMC229 |
| 2004 |
Maus, U., Srivastava, M., Paton, J., Mack, M., Everhart, M., Blackwell, T., . . . Lohmeyer, J. (2004). Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. Journal of Immunology, 173(2), 1307-1312.
DOI Scopus77 WoS67 Europe PMC54 |
| 2004 |
Morona, J., Miller, D., Morona, R., & Paton, J. (2004). The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae. Journal of Infectious Diseases, 189(10), 1905-1913.
DOI Scopus112 WoS104 Europe PMC98 |
| 2004 |
Pinyon, R., Paton, J., Paton, A., Botten, J., & Morona, R. (2004). Refinement of a therapeutic Shiga toxin-binding probiotic for human trials. Journal of Infectious Diseases, 189(9), 1547-1555.
DOI Scopus37 WoS28 Europe PMC21 |
| 2004 |
Brown, J. S., Ogunniyi, A. D., Woodrow, M. C., Holden, D. W., & Paton, J. C. (2004). Erratum: Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection (Infection and Immunity (2001) 69, 11 (6702-6706)). Infection and Immunity, 72(11), 6755.
DOI Scopus1 WoS1 |
| 2004 |
Paton, A. W., Srimanote, P., Talbot, U. M., Wang, H., & Paton, J. C. (2004). Erratum: (Journal of Experimental Medicine (July 5, 2004) 200, 1 (35-46)). Journal of Experimental Medicine, 200(11), 1525.
DOI Scopus4 WoS2 |
| 2003 |
Malley, R., Henneke, P., Morse, S., Cieslewicz, M., Lipsitch, M., Thompson, C., . . . Golenbock, D. (2003). Recognition of pneumolysin by toll-like receptor 4 confers resistance to pneumococcal infection. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 1966-1971.
DOI Scopus600 WoS525 Europe PMC481 |
| 2003 |
Jenkins, C., Perry, N., Cheasty, T., Shaw, D., Frankel, G., Dougan, G., . . . Paton, J. (2003). Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins. Journal of Clinical Microbiology, 41(4), 1775-1778.
DOI Scopus76 WoS72 Europe PMC57 |
| 2003 |
Chapuy-Regaud, S., Ogunniyi, A., Diallo, N., Huet, Y., Desnottes, J., Paton, J., . . . Trombe, M. (2003). RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae. Infection and Immunity, 71(5), 2615-2625.
DOI Scopus40 WoS34 Europe PMC34 |
| 2003 |
Morona, J., Morona, R., Miller, D., & Paton, J. (2003). Mutational analysis of the carboxy-terminal (YGX)4 repeat domain of CpsD, an autophosphorylating tyrosine kinase required for capsule biosynthesis in Streptococcus pneumoniae. Journal of Bacteriology, 185(10), 3009-3019.
DOI Scopus81 WoS71 Europe PMC61 |
| 2003 |
Stroeher, U., Paton, A., Ogunniyi, A., & Paton, J. (2003). Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model. Infection and Immunity, 71(6), 3206-3212.
DOI Scopus85 WoS76 Europe PMC65 |
| 2003 |
Kwon, H., Kim, S., Choi, M., Ogunniyi, A., Paton, J., Park, S., . . . Rhee, D. (2003). Effect of heat shock and mutations in ClpL and ClpP on virulence gene expression in Streptococcus pneumoniae. Infection and Immunity, 71(7), 3757-3765.
DOI Scopus98 WoS92 Europe PMC85 |
| 2003 |
Briles, D., Hollingshead, S., Paton, J., Ades, E., Novak, L., van Ginkel, F., & Benjamin Jr, W. (2003). Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. Journal of Infectious Diseases, 188(3), 339-348.
DOI Scopus208 WoS192 Europe PMC173 |
| 2003 |
Rogers, T., Paton, A., McColl, S., & Paton, J. (2003). Enhanced CXC chemokine responses of human colonic epithelial cells to locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli. Infection and Immunity, 71(10), 5623-5632.
DOI Scopus35 WoS34 Europe PMC31 |
| 2002 |
Brown, J., Hussell, T., Gilliland, S., Holden, D., Paton, J., Ehrenstein, M., . . . Botto, M. (2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proceedings of the National Academy of Sciences of the United States of America, 99(26), 16969-16974.
DOI Scopus319 WoS280 Europe PMC253 |
| 2002 |
Tseng, H., McEwan, A., Paton, J., & Jennings, M. (2002). Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress. Infection and Immunity, 70(3), 1635-1639.
DOI Scopus131 WoS122 Europe PMC96 |
| 2002 |
Duthy, T., Ormsby, R., Giannakis, E., Ogunniyi, A., Stroeher, U., Paton, J., & Gordon, D. (2002). The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15. Infection and Immunity, 70(10), 5604-5611.
DOI Scopus74 WoS66 Europe PMC59 |
| 2002 |
Ogunniyi, A., Giammarinaro, P., & Paton, J. (2002). The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology, 148(Part 7), 2045-2053.
DOI Scopus122 WoS109 Europe PMC93 |
| 2002 |
Morona, J., Morona, R., Miller, D., & Paton, J. (2002). Streptococcus pneumoniae capsule biosynthesis protein CpsB is a novel manganese-dependent phosphotyrosine-protein phosphatase. Journal of Bacteriology, 184(2), 577-583.
DOI Scopus111 WoS95 Europe PMC86 |
| 2002 |
Giammarinaro, P., & Paton, J. (2002). Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae. Infection and Immunity, 70(10), 5454-5461.
DOI Scopus102 WoS93 Europe PMC85 |
| 2002 |
Paton, A., & Paton, J. (2002). Reactivity of convalescent-phase hemolytic-uremic syndrome patient sera with the megaplasmid-encoded TagA protein of Shiga toxigenic Escherichia coli O157. Journal of Clinical Microbiology, 40(4), 1395-1399.
DOI Scopus15 WoS11 Europe PMC11 |
| 2002 |
Paton, A., & Paton, J. (2002). Direct detection and characterization of Shiga toxigenic Escherichia coli by multiplex PCR for stx1, stx2, eae, ehxA, and saa. Journal of Clinical Microbiology, 40(1), 271-274.
DOI Scopus287 WoS257 Europe PMC198 |
| 2002 |
Srimanote, P., Paton, A., & Paton, J. (2002). Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli strains that are virulent for humans. Infection and Immunity, 70(6), 3094-3100.
DOI Scopus54 WoS48 Europe PMC40 |
| 2001 |
Paton, J., & Giammarinaro, P. (2001). Genome-based analysis of pneumococcal virulence factors: the quest for novel vaccine antigens and drug targets. Trends in Microbiology, 9(11), 515-518.
DOI Scopus19 WoS17 Europe PMC9 |
| 2001 |
Briles, D., Hollingshead, S., Nabors, G., Paton, J., & Brooks-Walter, A. (2001). The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae. Vaccine, 19(SUPPL. 1), S87-S95.
DOI Scopus125 WoS104 Europe PMC79 |
| 2001 |
Balachandran, P., Hollingshead, S., Paton, J., & Briles, D. (2001). The autolylic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin. Journal of Bacteriology, 183(10), 3108-3116.
DOI Scopus107 WoS89 Europe PMC82 |
| 2001 |
Ogunniyi, A., Woodrow, M., Poolman, J., & Paton, J. (2001). Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA. Infection and Immunity, 69(10), 5997-6003.
DOI Scopus134 WoS113 Europe PMC103 |
| 2001 |
Paton, J., Rogers, T., Morona, R., & Paton, A. (2001). Oral administration of formaldehyde-killed recombinant bacteria expressing a mimic of the shiga toxin receptor protects mice from fatal challenge with shiga-toxigenic Escherichia coli. Infection and Immunity, 69(3), 1389-1393.
DOI Scopus44 WoS39 Europe PMC27 |
| 2001 |
Paton, A., Morona, R., & Paton, J. (2001). Neutralization of shiga toxins Stx1, Stx2c, and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infection and Immunity, 69(3), 1967-1970.
DOI Scopus63 WoS55 Europe PMC47 |
| 2001 |
Brown, J., Ogunniyi, A., Woodrow, M., Holden, D., & Paton, J. (2001). Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infection and Immunity, 69(11), 6702-6706.
DOI Scopus152 WoS135 Europe PMC118 |
| 2001 |
Paton, A., Srimanote, P., Woodrow, M., & Paton, J. (2001). Characterization of Saa, a novel autoagglutinating adhesin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli strains that are virulent for humans. Infection and Immunity, 69(11), 6999-7009.
DOI Scopus324 WoS291 Europe PMC235 |
| 2001 |
Brown, J. S., Ogunniyi, A. D., Gilliland, S. N., Woodrow, M. C., Holden, D. W., & Paton, J. C. (2001). Immunisation with ABC transporter proteins protects against Streptococcus pneumoniae infection. THORAX, 56, 26. |
| 2000 |
Berry, A., & Paton, J. (2000). Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulance proteins. Infection and Immunity, 68(1), 133-140.
DOI Scopus217 WoS190 Europe PMC171 |
| 2000 |
Ogunniyi, A., Folland, R., Briles, D., Hollingshead, S., & Paton, J. (2000). Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infection and Immunity, 68(5), 3028-3033.
DOI Scopus184 WoS165 Europe PMC139 |
| 2000 |
Ogierman, M., Paton, A., & Paton, J. (2000). Up-Regulation of both Intimin and eae-independent adherence of Shiga toxigenic Escherichia coli O157 by ler and phenotypic impact of a naturally occurring ler mutation. Infection and Immunity, 68(9), 5344-5353.
DOI Scopus18 WoS16 Europe PMC13 |
| 2000 |
McKessar, S., Berry, A., Bell, J., Turnidge, J., & Paton, J. (2000). Genetic characterization of vanG, a novel Vancomycin resistance locus of Enterococcus faecalis. Antimicrobial Agents and Chemotherapy, 44(11), 3224-3228.
DOI Scopus166 WoS126 Europe PMC106 |
| 2000 |
Morona, J., Paton, J., Miller, D., & Morona, R. (2000). Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in Streptococcus pneumoniae. Molecular Microbiology, 35(6), 1431-1442.
DOI Scopus196 WoS173 Europe PMC159 |
| 2000 |
Paton, A., Morona, R., & Paton, J. (2000). A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine, 6(3), 265-270.
DOI Scopus191 WoS162 Europe PMC120 |
| 2000 |
Rapola, S., Jantti, V., Haikala, R., Syrjanen, R., Carlone, G. M., Sampson, J. S., . . . Kayhty, H. (2000). Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. Journal of Infectious Diseases, 182(4), 1146-1152.
DOI Scopus142 WoS126 Europe PMC103 |
| 2000 |
Briles, D. E., Ades, E., Paton, J. C., Sampson, J. S., Carlone, G. M., Huebner, R. C., . . . Hollingshead, S. K. (2000). Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infection and Immunity, 68(2), 796-800.
DOI Scopus281 WoS247 Europe PMC218 |
| 1999 |
Auzat, I., Chapuy-Regaud, S., Bras, G. L., Santos, D. D., Ogunniyi, A. D., Thomas, I. L., . . . Trombe, M. C. (1999). The NADH oxidase of Streptococcus pneumoniae: Its involvement in competence and virulence. Molecular Microbiology, 34(5), 1018-1028.
DOI Scopus115 WoS102 Europe PMC93 |
| 1999 |
Palmen, R., Ogunniyi, A. D., Berroy, P., Larpin, S., Paton, J. C., & Trombe, M. C. (1999). Insertional mutation of orfD of the DCW cluster of Streptococcus pneumoniae attenuates virulence. Microbial Pathogenesis, 27(6), 337-348.
DOI Scopus5 WoS5 Europe PMC4 |
| 1999 |
Paton, A. W., & Paton, J. C. (1999). Molecular characterization of the locus encoding biosynthesis of the lipopolysaccharide O antigen of Escherichia coli serotype O113. Infection and Immunity, 67(11), 5930-5937.
DOI Scopus51 WoS47 Europe PMC43 |
| 1999 |
Paton, A. W., & Paton, J. C. (1999). Direct detection of Shiga toxigenic Escherichia coli strains belonging to serogroups O111, O157, and O113 by multiplex PCR. Journal of Clinical Microbiology, 37(10), 3362-3365.
DOI Scopus64 WoS62 Europe PMC43 |
| 1999 |
Paton, A. W., Woodrow, M. C., Doyle, R. M., Lanser, J. A., & Paton, J. C. (1999). Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic- uremic syndrome. Journal of Clinical Microbiology, 37(10), 3357-3361.
DOI Scopus262 WoS243 Europe PMC213 |
| 1999 |
Lankinen, K. S., Ruutu, P., Nohynek, H., Lucero, M., Paton, J. C., & Leinonen, M. (1999). Pneumococcal pneumonia diagnosis by demonstration of pneumolysin antibodies in precipitated immune complexes. A study in 350 Philippine children with acute lower respiratory infection. Scandinavian Journal of Infectious Diseases, 31(2), 155-161.
DOI Scopus7 WoS7 Europe PMC5 |
| 1999 |
Claverys, J. P., Granadel, C., Berry, A. M., & Paton, J. C. (1999). Penicillin tolerance in Streptococcus pneumoniae, autolysis and the Psa ATP-binding cassette (ABC) manganese permease. Molecular Microbiology, 32(4), 881-883.
DOI Scopus22 WoS21 Europe PMC18 |
| 1999 |
Morona, J., Miller, D., Coffey, T., Vindurampulle, C., Spratt, B., Morona, R., & Paton, J. (1999). Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F. Microbiology - UK, 145(4), 781-789.
DOI Scopus29 WoS23 Europe PMC19 |
| 1999 |
Morona, J., Morona, R., & Paton, J. (1999). Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types beloning to serogroup 19. Journal of Bacteriology, 181(17), 5355-5364.
DOI Scopus57 WoS51 Europe PMC47 |
| 1999 |
Morona, J., Morona, R., & Paton, J. (1999). Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae. Journal of Bacteriology, 181(11), 3599-3605.
DOI Scopus41 WoS35 Europe PMC31 |
| 1999 |
Berry, A., Ogunniyi, A., Miller, D., & Paton, J. (1999). Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene. Infection and Immunity, 67(2), 981-985.
DOI Scopus76 WoS73 Europe PMC59 |
| 1998 |
Paton, A., Manning, P., Woodrow, M., & Paton, J. (1998). Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity.. Infection and Immunity, 66(11), 5580-5586.
DOI Scopus57 WoS49 Europe PMC34 |
| 1998 |
Voss, E., Paton, A., Manning, P., & Paton, J. (1998). Molecular analysis of shiga toxigenic Escherichia coli O111:H proteins which react with sera from patients with hemolytic-uremic syndrome.. Infection and Immunity, 66(4), 1467-1472.
DOI Scopus32 WoS27 Europe PMC24 |
| 1998 |
Paton, A., Voss, E., Manning, P., & Paton, J. (1998). Antibodies to lipopolysaccharide block adherence of shiga toxin-producing Escherichia coli to human intestinal epithelial (Henle 407) cells.. Microbial Pathogenesis, 24(1), 57-63.
DOI Scopus43 WoS41 Europe PMC40 |
| 1998 |
Coffey, T., Enright, M., Daniels, M., Morona, J., Morona, R., Hryniewicz, W., . . . Spratt, B. (1998). Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.. Molecular Microbiology, 27(1), 73-83.
DOI Scopus282 WoS249 Europe PMC205 |
| 1998 |
Pilling, P. A., Lawrence, M. C., Berry, A. M., Ogunniyi, A. D., Lock, R. A., & Paton, J. C. (1998). Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae. Acta Crystallographica Section D Biological Crystallography, 54(6 PART II), 1464-1466.
DOI Scopus30 WoS29 Europe PMC21 |
| 1998 |
Rubins, J. B., Paddock, A. H., Charboneau, D., Berry, A. M., Paton, J. C., & Janoff, E. N. (1998). Pneumolysin in pneumococcal adherence and colonization. Microbial Pathogenesis, 25(6), 337-342.
DOI Scopus39 WoS31 Europe PMC27 |
| 1998 |
Lawrence, M. C., Pilling, P. A., Epa, V. C., Berry, A. M., Ogunniyi, A. D., & Paton, J. C. (1998). The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein. Structure, 6(12), 1553-1561.
DOI Scopus195 WoS179 Europe PMC138 |
| 1998 |
Rossjohn, J., Gilbert, R. J. C., Crane, D., Morgan, P. J., Mitchell, T. J., Rowe, A. J., . . . Parker, M. W. (1998). The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. Journal of Molecular Biology, 284(2), 449-461.
DOI Scopus103 WoS90 Europe PMC66 |
| 1998 |
Bell, J. M., Paton, J. C., & Turnidge, J. (1998). Emergence of vancomycin-resistant enterococci in Australia: Phenotypic and genotypic characteristics of isolates. Journal of Clinical Microbiology, 36(8), 2187-2190.
DOI Scopus187 WoS174 Europe PMC118 |
| 1998 |
Paton, J. C., & Paton, A. W. (1998). Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clinical Microbiology Reviews, 11(3), 450-479.
DOI Scopus1313 WoS1158 Europe PMC811 |
| 1998 |
Alexander, J. E., Berry, A. M., Paton, J. C., Rubins, J. B., Andrew, P. W., & Mitchell, T. J. (1998). Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microbial Pathogenesis, 24(3), 167-174.
DOI Scopus48 WoS40 Europe PMC32 |
| 1998 |
Paton, J. C. (1998). Novel pneumococcal surface proteins: role in virulence and vaccine potential.. Trends in Microbiology, 6(3), 85-88.
DOI Scopus64 WoS63 Europe PMC54 |
| 1998 |
Paton, A. W., & Paton, J. C. (1998). Detection and characterization of shiga toxigenic escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfb(O111), and rfb(O157). Journal of Clinical Microbiology, 36(2), 598-602.
DOI Scopus1174 WoS1024 Europe PMC735 |
| 1997 |
Benton, K. A., Paton, J. C., & Briles, D. E. (1997). The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model. Microbial Pathogenesis, 23(4), 201-209.
DOI Scopus48 WoS44 Europe PMC40 |
| 1997 |
Paton, A. W., Voss, E., Manning, P. A., & Paton, J. C. (1997). Shiga toxin-producing Escherichia coli isolates from cases of human disease show enhanced adherence to intestinal epithelial (Henle 407) cells. Infection and Immunity, 65(9), 3799-3805.
DOI Scopus34 WoS31 Europe PMC28 |
| 1997 |
Paton, J. C., & Paton, A. W. (1997). Instability of a shiga toxin type 2 gene in Enterobacter cloacae [3]. Journal of Clinical Microbiology, 35(7), 1917.
DOI Scopus18 WoS16 Europe PMC12 |
| 1997 |
Benton, K. A., Paton, J. C., & Briles, D. E. (1997). Differences in virulence for mice among Streptococcus pneumoniae strains of capsular types 2, 3, 4, 5, and 6 are not attributable to differences in pneumolysin production. Infection and Immunity, 65(4), 1237-1244.
DOI Scopus64 WoS57 Europe PMC51 |
| 1997 |
Paton, J. C., Berry, A. M., & Lock, R. A. (1997). Molecular analysis of putative pneumococcal virulence proteins. Microbial Drug Resistance, 3(1), 1-10.
DOI Scopus58 WoS51 Europe PMC40 |
| 1997 |
Canvin, J. R., Paton, J. C., Boulnois, G. J., Andrew, P. W., & Mitchell, T. J. (1997). Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin. Microbial Pathogenesis, 22(3), 129-132.
DOI Scopus9 WoS10 Europe PMC8 |
| 1997 |
Paton, J., Morona, J., & Morona, R. (1997). Characterization of the Capsular Polysaccharide Biosynthesis Locus of Streptococcus pneumoniae Type 19F. Microbial Drug Resistance-Mechanisms Epidemiology and Disease, 3(1), 89-99.
DOI Scopus4 WoS5 Europe PMC4 |
| 1997 |
Morona, J., Morona, R., & Paton, J. (1997). Molecular and Genetic Characterization of the Capsule Biosynthesis Locus Of Streptococcus pneumoniae Type 19B. Journal of Bacteriology, 179(15), 4953-4958.
DOI Scopus38 WoS34 Europe PMC31 |
| 1997 |
Morona, J., Morona, R., & Paton, J. (1997). Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biuosynthetic pathway. Molecular Microbiology, 23(4), 751-763.
DOI Scopus102 WoS97 Europe PMC76 |
| 1997 |
Paton, A., Voss, E., Manning, P., & Paton, J. (1997). Enhanced adherence of Shiga-like toxin-producing Escherichia coli isolates from cases of human disease to intestinal epithelial (Henle 407) cells. Infection and Immunity, 65, 3799-3805. |
| 1997 |
Jureidini, K. F., Henning, P. H., AlAbbad, A., Keeley, S., Paton, J. C., & Paton, A. W. (1997). Outbreak of HUS associated with verotoxigenic E-coli and dry fermented sausage.. KIDNEY INTERNATIONAL, 51(4), 1305.
WoS2 |
| 1996 |
Rubins, J. B., Charboneau, D., Fasching, C., Berry, A. M., Paton, J. C., Alexander, J. E., . . . Janoff, E. N. (1996). Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine, 153(4), 1339-1346.
DOI Scopus94 WoS88 |
| 1996 |
Berry, A. M., & Paton, J. C. (1996). Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae. Infection and Immunity, 64(12), 5255-5262.
DOI Scopus237 WoS213 Europe PMC174 |
| 1996 |
Talbot, U. M., Paton, A. W., & Paton, J. C. (1996). Uptake of Streptococcus pneumoniae by respiratory epithelial cells. Infection and Immunity, 64(9), 3772-3777.
DOI Scopus133 WoS119 Europe PMC95 |
| 1996 |
Lock, R. A., Zhang, Q. Y., Berry, A. M., & Paton, J. C. (1996). Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin. Microbial Pathogenesis, 21(2), 71-83.
DOI Scopus48 WoS41 Europe PMC32 |
| 1996 |
Berry, A. M., Lock, R. A., & Paton, J. C. (1996). Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the Nanb enzyme from recombinant Escherichia coli. Journal of Bacteriology, 178(16), 4854-4860.
DOI Scopus84 WoS75 Europe PMC61 |
| 1996 |
Paton, A. W., Ratcliff, R. M., Doyle, R. M., Seymour-Murray, J., Davos, D., Lanser, J. A., & Paton, J. C. (1996). Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli. Journal of Clinical Microbiology, 34(7), 1622-1627.
DOI Scopus285 WoS253 Europe PMC184 |
| 1996 |
Paton, J. C., & Paton, A. W. (1996). Survival rate of mice after transient colonization with Escherichia coli clones carrying variant Shiga-like toxin type II operons. Microbial Pathogenesis, 20(6), 377-383.
DOI Scopus8 WoS8 Europe PMC7 |
| 1996 |
Rubins, J. B., Charboneau, D., Fasching, C., Berry, A. M., Paton, J. C., Alexander, J. E., . . . Janoff, E. N. (1996). Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia.. American journal of respiratory and critical care medicine, 153(4 Pt 1), 1339-1346.
DOI Europe PMC66 |
| 1996 |
Paton, J. C. (1996). The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae. Trends in Microbiology, 4(3), 103-106.
DOI Scopus105 WoS101 Europe PMC85 |
| 1996 |
Paton, A. W., & Paton, J. C. (1996). Enterobacter cloacae producing a Shiga-like toxin II-related cytotoxin associated with a case of hemolytic-uremic syndrome. Journal of Clinical Microbiology, 34(2), 463-465.
DOI Scopus101 WoS89 Europe PMC65 |
| 1995 |
Friedland, I. R., Paris, M. M., Hickey, S., Shelton, S., Olsen, K., Paton, J. C., & Mc Cracken, G. H. (1995). The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis. Journal of Infectious Diseases, 172(3), 805-809.
DOI Scopus48 WoS45 Europe PMC39 |
| 1995 |
Canvin, J. R., Marvin, A. P., Sivakumaran, M., Paton, J. C., Boulnois, G. J., Andrew, P. W., & Mitchell, T. J. (1995). The Role of Pneumolysin and Autolysin in the Pathology of Pneumonia and Septicemia in Mice Infected with a Type 2 Pneumococcus. Journal of Infectious Diseases, 172(1), 119-123.
DOI Scopus176 WoS148 Europe PMC142 |
| 1995 |
Berry, A. M., Alexander, J. E., Mitchell, T. J., Andrew, P. W., Hansman, D., & Paton, J. C. (1995). Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infection and Immunity, 63(5), 1969-1974.
DOI Scopus96 WoS84 Europe PMC69 |
| 1995 |
Paton, A. W., Beutin, L., & Paton, J. C. (1995). Heterogeneity of the amino-acid sequences of Escherichia coli shiga-like toxin type-I operons. Gene, 153(1), 71-74.
DOI Scopus77 WoS70 Europe PMC54 |
| 1995 |
Rubins, J. B., Charboneau, D., Paton, J. C., Mitchell, T. J., Andrew, P. W., & Janoff, E. N. (1995). Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Journal of Clinical Investigation, 95(1), 142-150.
DOI Scopus121 WoS110 Europe PMC94 |
| 1995 |
Paton, A., Bourne, A., Manning, P., & Paton, J. (1995). Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons. Infection and Immunity, 63(7), 2450-2458.
DOI Scopus42 WoS42 Europe PMC32 |
| 1995 |
Cameron, A., Beers, M., Walker, C., Rose, N., Anear, E., Manatakis, Z., . . . Ratcliff, R. (1995). Community outbreak of hemolytic uremic syndrome attributable to Escherichia Coli O111:NM - South Australia, 1995. Mortality and Morbidity Weekly Review, 44(29), 550-558. |
| 1995 |
Paton, A., Manning, P., & Paton, J. (1995). Increased oral virulence of Escherichia coli expressing a variant Shiga-like toxin type II operon is associated with both A subunit residues Met4 and Gly102. Microbial Pathgenesis, 19(3), 185-191.
DOI Scopus5 WoS6 Europe PMC4 |
| 1995 |
Guildolin, A., Morona, J. K., Morona, R., Hansman, D., & Paton, J. C. (1995). Nucleotide sequence analysis of genes essential for production of Streptococcus pneumoniae type 19F capsular polysaccharide.. Developments in Biological Standardization, 85, 267-271.
Scopus3 WoS3 Europe PMC3 |
| 1994 |
Morona, J. K., Guidolin, A., Morona, R., Hansman, D., & Paton, J. C. (1994). Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae. Journal of Bacteriology, 176(14), 4437-4443.
DOI Scopus34 WoS39 Europe PMC24 |
| 1994 |
Guidolin, A., Morona, J. K., Morona, R., Hansman, D., & Paton, J. C. (1994). Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F. Infection and Immunity, 62(12), 5384-5396.
DOI Scopus120 WoS117 Europe PMC91 |
| 1994 |
Lee, C. J., Lock, R. A., Andrew, P. W., Mitchell, T. J., Hansman, D., & Paton, J. C. (1994). Protection of infant mice from challenge with Strptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide-pneumolysoid conjugate. Vaccine, 12(10), 875-878.
DOI Scopus39 WoS32 Europe PMC26 |
| 1994 |
Berry, A. M., Lock, R. A., Thomas, S. M., Rajan, D. P., Hansman, D., & Paton, J. C. (1994). Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli. Infection and Immunity, 62(3), 1101-1108.
DOI Scopus102 WoS94 Europe PMC70 |
| 1994 |
Paton, A. W., & Paton, J. C. (1994). Characterization of IS1203, an insertion sequence in Escherichia coli 0111:H-. Gene, 150(1), 67-70.
DOI Scopus21 WoS20 Europe PMC13 |
| 1994 |
Alexander, J. E., Lock, R. A., Peeters, C. C. A. M., Poolman, J. T., Andrew, P. W., Mitchell, T. J., . . . Paton, J. C. (1994). Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infection and Immunity, 62(12), 5683-5688.
DOI Scopus200 WoS185 Europe PMC148 |
| 1993 |
Paton, A. W., Paton, J. C., Goldwater, P. N., & Manning, P. A. (1993). Direct detection of Escherichia coli Shiga-like toxin genes in primary fecal cultures by polymerase chain reaction. Journal of Clinical Microbiology, 31(11), 3063-3067.
DOI Scopus114 WoS112 Europe PMC75 |
| 1993 |
Paton, A. W., Paton, J. C., Goldwater, P. N., Heuzenroeder, M. W., & Manning, P. A. (1993). Sequence of a variant Shiga-like toxin type-I operon of Eschirichia coli 0111:H-. Gene, 129(1), 87-92.
DOI Scopus59 WoS59 Europe PMC42 |
| 1993 |
Paton, A. W., Paton, J. C., & Manning, P. A. (1993). Polymerase chain reaction amplification, cloning and sequencing of variant escherichia coli Shiga-like toxin type II operons. Microbial Pathogenesis, 15(1), 77-82.
DOI Scopus49 WoS48 Europe PMC39 |
| 1993 |
Paton, J. C., Andrew, P. W., Boulnois, G. J., & Mitchell, T. J. (1993). Molecular analysis of the pathogenicity of Streptococcus pneumoniae: The role of pneumococcal proteins. Annual Review of Microbiology, 47(1), 89-115.
DOI Scopus218 WoS202 Europe PMC161 |
| 1993 |
Paton, J. C., Morona, J. K., Harrer, S., Hansman, D., & Morona, R. (1993). Immunization of mice with Salmonella typhimurium C5 aroA expressing a genetically toxoided derivative of the pneumococcal toxin pneumolysin. Microbial Pathogenesis, 14(2), 95-102.
DOI Scopus9 WoS8 Europe PMC4 |
| 1993 |
Paton, J. C. (1993). Pathogenesis of pneumococcal disease. Current Opinion in Infectious Diseases, 6(3), 363-368.
Scopus4 WoS2 |
| 1992 |
Paton, A. W., Paton, J. C., Heuzenroeder, M. W., Goldwater, P. N., & Manning, P. A. (1992). Cloning and nucleotide sequence of a variant Shiga-like toxin II gene from Escherichia coli OX3:H21 isolated from a case of sudden infant death syndrome. Microbial Pathogenesis, 13(3), 225-236.
DOI Scopus67 WoS67 Europe PMC53 |
| 1992 |
Paton, A. W., Paton, J. C., Lawrence, A. J., Goldwater, P. N., & Harris, R. J. (1992). Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by reverse transcription and polymerase chain reaction amplification. Journal of Clinical Microbiology, 30(4), 901-904.
DOI Scopus102 WoS85 Europe PMC74 |
| 1992 |
Berry, A. M., Paton, J. C., & Hansman, D. (1992). Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3. Microbial Pathogenesis, 12(2), 87-93.
DOI Scopus68 WoS55 Europe PMC53 |
| 1992 |
Lock, R. A., Hansman, D., & Paton, J. C. (1992). Comparative efficacy of autolysin and pneumolysin as immunogens protecting mice against infection by Streptococcus pneumoniae. Microbial Pathogenesis, 12(2), 137-143.
DOI Scopus73 WoS63 Europe PMC50 |
| 1991 |
Boulnois, G. J., Paton, J. C., Mitchell, T. J., & Andrew, P. W. (1991). Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae. Molecular Microbiology, 5(11), 2611-2616.
DOI Scopus111 WoS113 Europe PMC78 |
| 1991 |
Paton, J. C., Lock, R. A., Lee, C. J., Li, J. P., Berry, A. M., Mitchell, T. J., . . . Boulnois, G. J. (1991). Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infection and Immunity, 59(7), 2297-2304.
DOI Scopus127 WoS131 Europe PMC98 |
| 1990 |
Glare, E. M., Paton, J. C., Premier, R. R., Lawrence, A. J., & Nisbet, I. T. (1990). Analysis of a repetitive DNA sequence from Bordetella pertussis and its application to the diagnosis of pertussis using the polymerase chain reaction. Journal of Clinical Microbiology, 28(9), 1982-1987.
DOI Scopus164 WoS163 Europe PMC110 |
| 1990 |
Jalonen, E., Taira, S., Paton, J. C., Kerttula, Y., Suomalainen, P., & Leinonen, M. (1990). Pneumolysin, produced in Bacillus subtilis as antigen in enzyme immunoassay for etiological diagnosis of pneumococcal pneumonia. Serodiagnosis and Immunotherapy in Infectious Disease, 4(6), 459-468.
DOI Scopus7 WoS12 |
| 1990 |
Mitchell, T. J., Mendez, F., Paton, J. C., Andrew, P. W., & Boulnois, G. J. (1990). Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2. Nucleic Acids Research, 18(13), 4010.
DOI Scopus35 WoS40 Europe PMC28 |
| 1989 |
Berry, A. M., Glare, E. M., Hansman, D., & Paton, J. C. (1989). Presence of a small plasmid in clinical isolates of Streptococcus pneumoniae. FEMS Microbiology Letters, 65(3), 275-278.
DOI Scopus6 |
| 1989 |
Berry, A. M., Glare, E. M., Hansman, D., & Paton, J. C. (1989). Presence of a small plasmid in clinical isolates of Streptococcus pneumoniae. FEMS Microbiology Letters, 65(3), 275-278.
DOI Scopus7 WoS6 Europe PMC3 |
| 1989 |
Jalonen, E., Paton, J. C., Koskela, M., Kerttula, Y., & Leinonen, M. (1989). Measurement of antibody responses to pneumolysin-A promising method for the presumptive aetiological diagnosis of pneumococcal pneumonia. Journal of Infection, 19(2), 127-134.
DOI Scopus95 WoS102 Europe PMC65 |
| 1989 |
Berry, A. M., Lock, R. A., Hansman, D., & Paton, J. C. (1989). Contribution of autolysin to virulence of Streptococcus pneumoniae. Infection and Immunity, 57(8), 2324-2330.
DOI Scopus210 WoS212 Europe PMC178 |
| 1989 |
Berry, A. M., Yother, J., Briles, D. E., Hansman, D., & Paton, J. C. (1989). Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infection and Immunity, 57(7), 2037-2042.
DOI Scopus262 WoS278 Europe PMC232 |
| 1989 |
Taira, S., Jalonen, E., Paton, J. C., Sarvas, M., & Runeberg-Nyman, K. (1989). Production of pneumolysin, a pneumococcal toxin, in Bacillus subtilis. Gene, 77(2), 211-218.
DOI Scopus26 WoS24 Europe PMC21 |
| 1989 |
Goldwater, P. N., & Paton, J. C. (1989). Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain. Journal of Neuropathology and Experimental Neurology, 48(2), 184-186.
DOI Scopus4 WoS4 Europe PMC3 |
| 1988 |
Lock, R. A., Paton, J. C., & Hansman, D. (1988). Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae. Microbial Pathogenesis, 5(6), 461-467.
DOI Scopus98 WoS101 Europe PMC70 |
| 1988 |
Berry, A. M., Paton, J. C., Glare, E. M., Hansman, D., & Catcheside, D. E. A. (1988). Cloning and expression of the pneumococcal neuraminidase gene in Escherichia coli. Gene, 71(2), 299-305.
DOI Scopus24 WoS33 Europe PMC22 |
| 1988 |
Lock, R. A., Paton, J. C., & Hansman, D. (1988). Purification and immunological characterization of neuraminidase produced by Streptococcus pneumoniae. Microbial Pathogenesis, 4(1), 33-43.
DOI Scopus39 WoS43 Europe PMC34 |
| 1987 |
Lawrence, A. J., & Paton, J. C. (1987). Efficacy of enzyme-linked immunosorbent assay for rapid diagnosis of Bordetella pertussis infection. Journal of Clinical Microbiology, 25(11), 2102-2104.
DOI Scopus20 WoS23 Europe PMC14 |
| 1986 |
Nandoskar, M., Ferrante, A., Bates, E. J., Hurst, N., & Paton, J. C. (1986). Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin. Immunology, 59(4), 515-520.
Scopus39 WoS51 Europe PMC41 |
| 1986 |
Douglas, R. M., Hansman, D., Miles, H. B., & Paton, J. C. (1986). Pneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy children. American Journal of Diseases of Children, 140(11), 1183-1185.
DOI Scopus51 WoS49 Europe PMC33 |
| 1986 |
Paton, J. C., Berry, A. M., Lock, R. A., Hansman, D., & Manning, P. A. (1986). Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infection and Immunity, 54(1), 50-55.
DOI Scopus53 WoS64 Europe PMC44 |
| 1986 |
Paton, J. C., Toogood, I. R., Cockington, R. A., & Hansman, D. (1986). Antibody response to pneumococcal vaccine in children aged 5 to 15 years. American Journal of Diseases of Children, 140(2), 135-138.
DOI Scopus45 WoS50 Europe PMC28 |
| 1986 |
Douglas, R. M., Hansman, D., McDonald, B., Paton, J., & Kirke, K. (1986). PNEUMOCOCCAL VACCINE IN ABORIGINAL CHILDREN—A RANDOMIZED CONTROLLED TRIAL INVOLVING 60 CHILDREN. Community Health Studies, 10(2), 189-196.
DOI Scopus17 Europe PMC11 |
| 1984 |
Ferrante, A., Rowan-Kelly, B., & Paton, J. C. (1984). Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infection and Immunity, 46(2), 585-589.
DOI Scopus58 WoS72 Europe PMC49 |
| 1984 |
Paton, J. C., Rowan Kelly, B., & Ferrante, A. (1984). Activation of human complement by the pneumococcal toxin pneumolysin. Infection and Immunity, 43(3), 1085-1087.
DOI Scopus172 WoS181 Europe PMC156 |
| 1983 |
Paton, J., & Ferrante, A. (1983). Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infection and Immunity, 41(3), 1212-1216.
DOI Scopus118 WoS142 Europe PMC112 |
| 1983 |
Douglas, R. M., Paton, J. C., Duncan, S. J., & Hansman, D. J. (1983). Antibody response to pneumococcal vaccination in children younger than five years of age. Journal of Infectious Diseases, 148(1), 131-137.
DOI Scopus361 WoS355 Europe PMC222 |
| 1983 |
Paton, J., Lock, R., & Hansman, D. (1983). Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infection and Immunity, 40(2), 548-552.
DOI Scopus149 WoS173 Europe PMC137 |
| 1983 |
Paton, J., Lawrence, A., & Steven, I. (1983). Quantities of Clostridium botulinum organisms and toxin in feces and presence of Clostridium botulinum toxin in the serum of an infant with botulism. Journal of Clinical Microbiology, 17(1), 13-15.
DOI Scopus25 WoS24 Europe PMC13 |
| 1982 |
Paton, J., Lawrence, A., & Manson, J. (1982). Quantitation of Clostridium botulinum organisms and toxin in the feces of an infant with botulism. Journal of Clinical Microbiology, 15(1), 1-4.
DOI Scopus15 WoS20 Europe PMC14 |
| 1980 |
Douglas, H. M., Manson, J. I., Paton, J. C., Hansman, D. J., Murrell, W. G., & Stewart, B. J. (1980). Infant botulism.. Medical Journal of Australia, 2(7), 398.
DOI Scopus10 WoS11 Europe PMC6 |
| 1980 |
PATON, J. C., MAY, B. K., & ELLIOTT, W. H. (1980). CERULENIN INHIBITS PRODUCTION OF EXTRACELLULAR PROTEINS BUT NOT MEMBRANE-PROTEINS IN BACILLUS-AMYLOLIQUEFACIENS. JOURNAL OF GENERAL MICROBIOLOGY, 118(MAY), 179-187.
WoS21 |
| 1980 |
Paton, J. C., May, B. K., & Elliott, W. H. (1980). Cerulenin inhibits production of extracellular proteins but not membrane proteins in Bacillus amyloliquefaciens. Journal of General Microbiology, 118(1), 179-187.
DOI Scopus13 |
| 1979 |
PATON, J. C., & ELLIOTT, W. H. (1979). FATTY-ACID SYNTHESIS IS REQUIRED FOR EXTRACELLULAR PROTEIN SECRETION BY BACILLUS AMYLOLIQUEFACIENS. PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 12, 109.
WoS1 |
| 1978 |
PATON, J. C., MAY, B. K., & ELLIOTT, W. H. (1978). PHOSPHOLIPID ASYMMETRY IN MEMBRANE OF BACILLUS-AMYLOLIQUEFACIENS. PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 11, 107. |
| 1978 |
Paton, J. C., McMurchie, E. J., May, B. K., & Elliott, W. H. (1978). Effect of growth temperature on membrane fatty acid composition and susceptibility to cold shock of Bacillus amyloliquefaciens. Journal of Bacteriology, 135(3), 754-759.
DOI Scopus17 WoS25 Europe PMC7 |
| 1978 |
Paton, J., May, B., & Elliott, W. (1978). Membrane phospholipid asymmetry in Bacillus amyloliquefaciens. Journal of Bacteriology, 135(2), 393-401.
DOI Scopus30 WoS31 Europe PMC15 |
