Professor James Paton

James Paton
Australian Fellow
School of Biological Sciences
Faculty of Sciences

Prof. James Paton is currently a NHMRC Senior Principal Research Fellow (formerly NHMRC Australia Fellow), Professor of Microbiology, and Director, Research Centre for Infectious Diseases (RCID), School of Biological Sciences, University of Adelaide.
As Director of the RCID,he is bringing together established and emerging researchers with synergistic skills to accelerate basic research into bacterial infectious disease pathogenesis, and translate basic discoveries into improved health outcomes.
The major research foci are:
• Basic bacterial pathogenesis and target discovery.
• Vaccine development.
• Novel anti-infectives and therapeutics.
The vision of the RCID is to be the pre-eminent Australian Centre of Excellence in research into the pathogenesis, treatment and prevention of bacterial infectious diseases, and to play a leading role in international collaborative efforts to fight these infections.
Its aims are:
• To build and co-localize a critical mass of researchers with multi-disciplinary expertise, but with a common focus on bacterial infectious diseases.
• To generate new knowledge on bacterial pathogenic mechanisms at a leading international level.
• To make a major contribution to global management of infectious diseases by translating basic research discoveries into new and improved vaccines and novel anti-infectives.
• To significantly increase external research income.
• To foster the professional development of HDR students and ECRs.
• To raise the profile of infectious diseases in the public arena, as well as with State and Federal Governments, with a view to influencing decisions re resource allocation.

Connect with me

Professor James Paton

Prof. James Paton is currently a NHMRC Senior Principal Research Fellow (formerly NHMRC Australia Fellow), Professor of Microbiology, and Director, Research Centre for Infectious Diseases (RCID), School of Biological Sciences, University of Adelaide.
As Director of the RCID,he is bringing together established and emerging researchers with synergistic skills to accelerate basic research into bacterial infectious disease pathogenesis, and translate basic discoveries into improved health outcomes.
The major research foci are:
• Basic bacterial pathogenesis and target discovery.
• Vaccine development.
• Novel anti-infectives and therapeutics.
The vision of the RCID is to be the pre-eminent Australian Centre of Excellence in research into the pathogenesis, treatment and prevention of bacterial infectious diseases, and to play a leading role in international collaborative efforts to fight these infections.
Its aims are:
• To build and co-localize a critical mass of researchers with multi-disciplinary expertise, but with a common focus on bacterial infectious diseases.
• To generate new knowledge on bacterial pathogenic mechanisms at a leading international level.
• To make a major contribution to global management of infectious diseases by translating basic research discoveries into new and improved vaccines and novel anti-infectives.
• To significantly increase external research income.
• To foster the professional development of HDR students and ECRs.
• To raise the profile of infectious diseases in the public arena, as well as with State and Federal Governments, with a view to influencing decisions re resource allocation.

Appointments

Date Position Institution name
2013 NHMRC Senior Principal Research Fellow University of Adelaide
2008 Director, Research Centre for Infectious Diseases University of Adelaide
2007 - 2013 NHMRC Australia Fellow University of Adelaide
2000 Professor of Microbiology University of Adelaide
1980 - 2000 Head, Molecular Microbiology Unit Women's and Children's Hospital

Education

Date Institution name Country Title
2015 American Academy of Microbiologists United States FAAM
2013 Academy of Sciences Australia FAA
1989 Australian Society for Microbiology Australia FASM
1979 University of Adelaide Australia PhD
1976 University of Adelaide Australia BSc(Hons)

Journals

Year Citation
2017 Glab, J., Doerflinger, M., Nedeva, C., Jose, I., Mbogo, G., Paton, J. ... Puthalakath, H. (2017). DR5 and caspase-8 are dispensable in ER stress-induced apoptosis. Cell Death and Differentiation, 24, 5, 944-950.
10.1038/cdd.2017.53
2017 McKenzie, D., Kara, E., Bastow, C., Tyllis, T., Fenix, K., Gregor, C. ... McColl, S. (2017). IL-17-producing γδ T cells switch migratory patterns between resting and activated states. Nature Communications, 8, 15632-1-15632-13.
10.1038/ncomms15632
2017 David, S., Lau, J., Singleton, E., Babb, R., Davies, J., Hirst, T. ... Alsharifi, M. (2017). The effect of gamma-irradiation conditions on the immunogenicity of whole-inactivated Influenza A virus vaccine. Vaccine, 35, 7, 1071-1079.
10.1016/j.vaccine.2016.12.044
2017 Naito-Matsui, Y., Davies, L., Takematsu, H., Chou, H., Tangvoranuntakul, P., Carlin, A. ... Varki, A. (2017). Physiological exploration of the long term evolutionary selection against expression of N-Glycolylneuraminic Acid in the Brain. Journal of Biological Chemistry, 292, 7, 2557-2570.
10.1074/jbc.M116.768531
2017 Kim, J., Lee, H., Rhee, D., Paton, J. & Pyo, S. (2017). Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells. Biochimica et Biophysica Acta - General Subjects, 1861, 11, 2663-2673.
10.1016/j.bbagen.2017.07.008
2017 Nain, M., Mukherjee, S., Karmakar, S., Paton, A., Paton, J., Abdin, M. ... Vrati, S. (2017). GRP78 is an important host factor for Japanese encephalitis virus entry and replication in mammalian cells. M. S. Diamond (Ed.). Journal of Virology, 91, 6, -.
10.1128/JVI.02274-16
2017 Mahdi, L., Higgins, M., Day, C., Tiralongo, J., Hartley-Tassell, L., Jennings, M. ... Ogunniyi, A. (2017). The pneumococcal alpha-glycerophosphate oxidase enhances nasopharyngeal colonization through binding to host glycoconjugates. EBioMedicine, Online, 1-8.
10.1016/j.ebiom.2017.03.002
2017 Herdman, B., Paton, J., Wang, H., Beddoe, T. & Paton, A. (2017). Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi.. Infection and immunity, 85, 8, IAI.00214-17-IAI.00214-17.
10.1128/iai.00214-17
2017 Cunningham, C., He, K., Arunagiri, A., Paton, A., Paton, J., Arvan, P. & Tsai, B. (2017). Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.. Diabetes, 66, 3, 741-753.
10.2337/db16-1338
2017 Day, C., Paton, A., Higgins, M., Shewell, L., Jen, F., Schulz, B. ... Jennings, M. (2017). Structure aided design of a Neu5Gc specific lectin. Scientific Reports, 7, 1, -.
10.1038/s41598-017-01522-9
2017 Littler, D., Ang, S., Moriel, D., Kocan, M., Kleifeld, O., Johnson, M. ... Beddoe, T. (2017). Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.. The Journal of biological chemistry, 292, 36, 1-32.
10.1074/jbc.m117.796094
2017 Seyahian, E. A., Oltra, G., Ochoa, F., Melendi, S., Hermes, R., Paton, J. C. ... Zotta, E. (2017). Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21. TOXICON, 127, 49-55.
10.1016/j.toxicon.2016.12.014
2017 Hassan, K., Pederick, V., Elbourne, L., Paulsen, I., Paton, J., McDevitt, C. & Eijkelkamp, B. (2017). Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology, 17, 1, 59-1-59-15.
10.1186/s12866-017-0965-y
2017 Chai, M., Weiland, F., Harvey, R., Hoffmann, P., Ogunniyi, A. & Paton, J. (2017). Proteomic comparisons of opaque and transparent variants of Streptococcus pneumoniae by two dimensional-differential gel electrophoresis. Scientific Reports, 7, 1, -.
10.1038/s41598-017-02465-x
2017 Amaral, M., Girard, M., Álvarez, R., Paton, A., Paton, J., Repetto, H. ... Ibarra, C. (2017). Ouabain protects human renal cells against the cytotoxic effects of Shiga toxin type 2 and subtilase cytotoxin. Toxins, 9, 7, 1-14.
10.3390/toxins9070226
2017 Trappetti, C. & Paton, J. (2017). Host-to-Host Transmission of the Pneumococcus—New Victims of a Toxic Relationship. Cell Host and Microbe, 21, 1, 5-6.
10.1016/j.chom.2016.12.011
2017 Trappetti, C., McAllister, L., Chen, A., Wang, H., Paton, A., Oggioni, M. ... Paton, J. (2017). Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by streptococcus pneumoniae, resulting in hypervirulence. L. McDaniel (Ed.). mBio, 8, 1, e02269-16-1-e02269-16-18.
10.1128/mBio.02269-16
2016 Babb, R., Chen, A., Ogunniyi, A., Hirst, T., Kara, E., McColl, S. ... Paton, J. (2016). Enhanced protective responses to a serotype-independent pneumococcal vaccine when combined with an inactivated influenza vaccine. Clinical Science, 131, 2, 169-180.
10.1042/CS20160475
2016 Babb, R., Chen, A., Hirst, T., Kara, E., McColl, S., Ogunniyi, A. ... Alsharifi, M. (2016). Intranasal vaccination with γ -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses. Clinical Science, 130, 9, 697-710.
10.1042/CS20150699
2016 van Lidth de Jeude, J., Meijer, B., Wielenga, M., Spaan, C., Baan, B., Rosekrans, S. ... Heijmans, J. (2016). Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells. Oncogene, Online, 24, 1-9.
10.1038/onc.2016.326
2016 Harvey, R., Trappetti, C., Mahdi, L., Wang, H., McAllister, L., Scalvini, A. ... Paton, J. (2016). The variable region of pneumococcal pathogenicity island 1 is responsible for unusually high virulence of a serotype 1 isolate. L. Pirofski (Ed.). Infection and Immunity, 84, 3, 822-832.
10.1128/IAI.01454-15
2016 McAllister, L., Bent, S., Petty, N., Skippington, E., Beatson, S., Paton, J. & Paton, A. (2016). Genomic comparison of two O111:H¯ Enterohemorrhagic Escherichia coli isolates from a historic hemolytic-uremic syndrome outbreak in Australia. B. McCormick (Ed.). Infection and Immunity, 84, 3, 775-781.
10.1128/IAI.01229-15
2016 Sabnis, A., Guerriero, C., Olivas, V., Sayana, A., Shue, J., Flanagan, J. ... Bivon, T. (2016). Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America, 113, 32, 9015-9020.
10.1073/pnas.1603883113
2016 Álvarez, R., Sacerdoti, F., Jancic, C., Paton, A., Paton, J., Ibarra, C. & Amaral, M. (2016). Comparative characterization of Shiga toxin type 2 and subtilase cytotoxin effects on human renal epithelial and endothelial cells grown in monolayer and bilayer conditions. R. Ramchandran (Ed.). PLoS One, 11, 6, e0158180-1-e0158180-14.
10.1371/journal.pone.0158180
2016 Mubarak, A., Ahmed, M., Upile, N., Vaughan, C., Xie, C., Sharma, R. ... Zhang, Q. (2016). A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans. Clinical Microbiology and Infection, 22, 8, 736.e1-736.e7.
10.1016/j.cmi.2016.05.017
2015 Chen, A., Mann, B., Gao, G., Heath, R., King, J., Maissoneuve, J. ... Paton, J. (2015). Multivalent pneumococcal protein vaccines comprising pneumolysoid with epitopes/fragments of CbpA and/or PspA elicit strong and broad protection. Clinical and Vaccine Immunology, 22, 10, 1079-1089.
10.1128/cvi.00293-15
2015 Robb, M., Robb, C., Higgins, M., Hobbs, J., Paton, J. & Boraston, A. (2015). A second β-hexosaminidase encoded in the streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. The Journal of Biological Chemistry, 290, 52, 30888-30900.
10.1074/jbc.M115.688630
2015 Mahdi, L., Van der Hoek, M., Ebrahimie, E., Paton, J. & Ogunniyi, A. (2015). Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model. PLoS One, 10, 11, e0141816-1-e0141816-15.
10.1371/journal.pone.0141816
2015 Knippenberg, S., Ueberberg, B., Maus, R., Bohling, J., Ding, N., Tort Tarres, M. ... Maus, U. (2015). Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax, 70, 7, 636-646.
10.1136/thoraxjnl-2014-206420
2015 Begg, S., Eijkelkamp, B., Luo, Z., Couñago, R., Morey, J., Maher, M. ... McDevitt, C. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6, 6418, 6418-1-6418-11.
10.1038/ncomms7418
2015 Adomako, A., Calvo, V., Biran, N., Osman, K., Chari, A., Paton, J. ... Aguirre-Ghiso, J. (2015). Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer, 15, 1, 444-1-444-11.
10.1186/s12885-015-1460-1
2015 Tikhomirova, A., Trappetti, C., Paton, J. & Kidd, S. (2015). The outcome of H. influenzae and S. pneumoniae inter-species interactions depends on pH, nutrient availability and growth phase. International Journal of Medical Microbiology, 305, 8, 881-892.
10.1016/j.ijmm.2015.09.003
2015 Paton, A., Chen, A., Wang, H., McAllister, L., Höggerl, F., Mayr, U. ... Paton, J. (2015). Protection against Shiga-toxigenic Escherichia coli by non-genetically modified organism receptor mimic bacterial ghosts. A. Bäumler (Ed.). Infection and Immunity, 83, 9, 3526-3533.
10.1128/IAI.00669-15
2015 Wielenga, M., Colak, S., Heijmans, J., van Lidth de Jeude, J., Rodermond, H., Paton, J. ... van den Brink, G. (2015). ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Reports, 13, 3, 489-494.
10.1016/j.celrep.2015.09.016
2015 Kara, E., McKenzie, D., Bastow, C., Gregor, C., Fenix, K., Ogunniyi, A. ... McColl, S. (2015). CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6, 8644-1-8644-1 7.
10.1038/ncomms9644
2015 Amin, Z., Harvey, R., Wang, H., Hughes, C., Paton, A., Paton, J. & Trappetti, C. (2015). Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15. Infection and Immunity, 83, 12, 4781-4790.
10.1128/IAI.01081-15
2015 Kim, J., Paton, J., Briles, D., Rhee, D. & Pyo, S. (2015). Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia. Oncotarget, 6, 42, 44161-44178.
10.18632/oncotarget.6592
2015 Le, N., Jeong, H., Kwon, H., Ogunniyi, A., Paton, J., Pyo, S. & Rhee, D. (2015). Erratum to Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL [Infection and Immunity, 75, 6 (2007) 2996-3005, 2007]. Infection and Immunity, 83, 3, 1224-.
10.1128/IAI.03125-14
2015 Pederick, V., Eijkelkamp, B., Begg, S., Ween, M., McAllister, L., Paton, J. & McDevitt, C. (2015). ZnuA and zinc homeostasis in pseudomonas aeruginosa. Scientific Reports, 5, 1, 13139-1-13139-14.
10.1038/srep13139
2015 Sun, S., Shi, G., Sha, H., Ji, Y., Han, X., Shu, X. ... Simpson, K. (2015). IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nature Cell Biology, 17, 12, 1546-1555.
10.1038/ncb3266
2015 Bajaj, M., Mamidyala, S., Zuegg, J., Begg, S., Ween, M., Luo, Z. ... Cooper, M. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10, 6, 1511-1520.
10.1021/cb501032x
2015 Barnett, T., Cole, J., Rivera-Hernandez, T., Henningham, A., Paton, J., Nizet, V. & Walker, M. (2015). Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17, 12, 1721-1741.
10.1111/cmi.12531
2015 Fruzangohar, M., Ebrahimie, E., Ogunniyi, A., Mahdi, L., Paton, J. & Adelson, D. (2015). Correction: Comparative GO: A web application for comparative gene ontology and gene ontology-based gene selection in bacteria. PLoS ONE, 10, 4, -.
10.1371/journal.pone.0125537
2015 Eijkelkamp, B., Pederick, V., Plumptre, C., Harvey, R., Hughes, C., Paton, J. & McDevitt, C. (2015). The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. A. Camilli (Ed.). Infection and Immunity, 84, 2, 407-415.
10.1128/IAI.01082-15
2015 Deplazes, E., Begg, S., van Wonderen, J., Campbell, R., Kobe, B., Paton, J. ... O'Mara, M. (2015). Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60.
10.1016/j.bpc.2015.08.004
2014 Eijkelkamp, B., Morey, J., Ween, M., Ong, C., McEwan, A., Paton, J. & McDevitt, C. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One, 9, 2, e89427-1-e89427-11.
10.1371/journal.pone.0089427
2014 Pederick, V., Eijkelkamp, B., Ween, M., Begg, S., Paton, J. & McDevitt, C. (2014). Acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80, 21, 6843-6852.
10.1128/aem.02465-14
2014 Hughes, C., Harvey, R., Plumptre, C. & Paton, J. (2014). Development of primary invasive pneumococcal disease caused by serotype 1 pneumococci is driven by early increased type I interferon response in the lung. Infection and Immunity, 82, 9, 3919-3926.
10.1128/IAI.02067-14
2014 Ng, P., Böhm, R., Hartley-Tassell, L., Steen, J., Wang, H., Lukowski, S. ... Jennings, M. (2014). Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors. Nature Communications, 5, 5750-1-5750-9.
10.1038/ncomms6750
2014 Fucho, R., Martínez, L., Baulies, A., Torres, S., Tarrats, N., Fernandez, A. ... García-Ruiz, C. (2014). ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. Journal of Hepatology, 61, 5, 1126-1134.
10.1016/j.jhep.2014.06.009
2014 Mahdi, L., Deihimi, T., Zamansani, F., Fruzangohar, M., Adelson, D., Paton, J. ... Ebrahimie, E. (2014). A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease. BMC Genomics, 15, 1, 769-1-769-15.
10.1186/1471-2164-15-769
2014 Plumptre, C., Hughes, C., Harvey, R., Eijkelkamp, B., McDevitt, C. & Paton, J. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity, 82, 10, 4315-4324.
10.1128/IAI.02155-14
2014 Potter, A. & Paton, J. (2014). Spermidine biosynthesis and transport modulate pneumococcal autolysis. Journal of Bacteriology, 196, 20, 3556-3561.
10.1128/JB.01981-14
2014 Plumptre, C., Eijkelkamp, B., Morey, J., Behr, F., Couñago, R., Ogunniyi, A. ... McDevitt, C. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91, 4, 834-851.
10.1111/mmi.12504
2014 Harvey, R., Hughes, C., Paton, A., Trappetti, C., Paton, J. & Tweten, R. (2014). The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. O. Neyrolles (Ed.). PLoS One, 9, 8, e103625-1-e103625-9.
10.1371/journal.pone.0103625
2014 Counago, R., Ween, M., Begg, S., Bajaj, M., Zuegg, J., O'Mara, M. ... McDevitt, C. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10, 1, 35-43.
10.1038/NCHEMBIO.1382
2014 Marquez, L., Velazquez, N., Repetto, H., Paton, A., Paton, J., Ibarra, C. & Silberstein, C. (2014). Effects of Escherichia coli Subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells. L. Johannes (Ed.). PLoS One, 9, 1, e87022-1-e87022-7.
10.1371/journal.pone.0087022
2014 Zacchi, L., Wu, H., Bell, S., Millen, L., Paton, A., Paton, J. ... Brodsky, J. (2014). The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA⁺ ATPase associated with the neurological disease early-onset torsion dystonia. Journal of Biological Chemistry, 289, 18, 12727-12747.
10.1074/jbc.M113.529123
2014 Wang, H., Rogers, T., Paton, J. & Paton, A. (2014). Differential effects of Escherichia coli subtilase cytotoxin and shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. Infection and Immunity, 82, 9, 3567-3579.
10.1128/IAI.02120-14
2014 Shewell, L., Harvey, R., Higgins, M., Day, C., Hartley-Tassell, L., Chen, A. ... Jennings, M. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity. Proceedings of the National Academy of Sciences of the United States of America, 111, 49, E5312-E5320.
10.1073/pnas.1412703111
2014 Leonard, A., Paton, A., El-Quadi, M., Paton, J. & Fazal, F. (2014). Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation. Y. Komarova (Ed.). PLoS One, 9, 10, e110949-1-e110949-18.
10.1371/journal.pone.0110949
2014 Lu, M., Lawrence, D., Marsters, S., Acosta-Alvear, D., Kimmig, P., Mendez, A. ... Ashkenazi, A. (2014). Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science, 345, 6192, 98-101.
10.1126/science.1254312
2014 Hostetter, S., Helgerson, A., Paton, J., Paton, A. & Cornick, N. (2014). Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome. BMC Research Notes, 7, 1, 331-1-331-8.
10.1186/1756-0500-7-331
2014 Manso, A., Chai, M., Atack, J., Furi, L., Croix, M., Haigh, R. ... Oggioni, M. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nature Communications, 5, 5055-1-5055-9.
10.1038/ncomms6055
2013 Fruzangohar, M., Ebrahimie, E., Ogunniyi, A., Mahdi, L., Paton, J. & Adelson, D. (2013). Comparative GO: a web application for comparative Gene Ontology and Gene Ontology-based gene selection in bacteria. PLoS One, 8, 3, 1-8.
10.1371/journal.pone.0058759
2013 Mahdi, L., Ebrahimie, E., Adelson, D., Paton, J. & Ogunniyi, A. (2013). A transcription factor contributes to pathogenesis and virulence in streptococcus pneumoniae. PLoS One, 8, 8, 1-9.
10.1371/journal.pone.0070862
2013 Wang, H., Paton, J., Herdman, B., Rogers, T., Beddoe, T. & Paton, A. (2013). The b subunit of an AB5 toxin produced by salmonella enterica serovar typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. Infection and Immunity, 81, 3, 673-683.
10.1128/IAI.01043-12
2013 Ng, N., Littler, D., Le Nours, J., Paton, A., Paton, J., Rossjohn, J. & Beddoe, T. (2013). Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB5 toxin. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, 69, 8, 912-915.
10.1107/S1744309113018927
2013 Ng, N., Littler, D., Paton, A., Le Nours, J., Rossjohn, J., Paton, J. & Beddoe, T. (2013). EcxAB is a founding member of a new family of metalloprotease AB₅ toxins with a hybrid cholera-like B subunit. Structure, 21, 11, 2003-2013.
10.1016/j.str.2013.08.024
2013 Heijmans, J., van Lidth de Jeude, J., Koo, B., Rosekrans, S., Wielenga, M., van de Wetering, M. ... van den Brink, G. (2013). ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports, 3, 4, 1128-1139.
10.1016/j.celrep.2013.02.031
2013 Shak, J., Ludewick, H., Howery, K., Sakai, F., Yi, H., Harvey, R. ... Vidal, J. (2013). Novel role for the Streptococcus pneumoniae toxin pneumolysin in the assembly of biofilms. MBio, 4, 5, 1-10.
10.1128/mBio.00655-13
2013 Plumptre, C., Ogunniyi, A. & Paton, J. (2013). Vaccination against Streptococcus pneumoniae using truncated derivatives of polyhistidine triad protein D. PLoS One, 8, 10, 1-11.
10.1371/journal.pone.0078916
2013 Basavanna, S., Chimalapati, S., Maqbool, A., Rubbo, B., Yuste, J., Wilson, R. ... Brown, J. (2013). The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence. PLoS One, 8, 1, 1-14.
10.1371/journal.pone.0049638
2013 Le Nours, J., Paton, A., Byres, E., Troy, S., Herdman, B., Johnson, M. ... Beddoe, T. (2013). Structural basis of subtilase cytotoxin SubAB assembly. Journal of Biological Chemistry, 288, 38, 27505-27516.
10.1074/jbc.M113.462622
2013 Gerhardt, E., Masso, M., Paton, A., Paton, J., Zotta, E. & Ibarra, C. (2013). Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21. Infection and Immunity, 81, 8, 2931-2937.
10.1128/IAI.00287-13
2013 Trappetti, C., van der Maten, E., Amin, Z., Potter, A., Chen, A., van Mourik, P. ... Paton, J. (2013). Site of isolation determines biofilm formation and virulence phenotypes of streptococcus pneumoniae serotype 3 clinical isolates. Infection and Immunity, 81, 2, 505-513.
10.1128/IAI.01033-12
2013 Ong, C., Potter, A., Trappetti, C., Walker, M., Jennings, M., Paton, J. & McEwan, A. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: Role of the orphan response regulator ritR. Infection and Immunity, 81, 2, 421-429.
10.1128/IAI.00805-12
2013 Johnson, N., Hassdenteufel, S., Theis, M., Paton, A., Paton, J., Zimmermann, R. & High, S. (2013). The signal sequence influences post-translational ER translocation at distinct stages. PLoS One, 8, 10, e75394-1-e75394-11.
10.1371/journal.pone.0075394
2013 Amaral, M., Sacerdoti, F., Jancic, C., Repetto, H., Paton, A., Paton, J. & Ibarra, C. (2013). Action of Shiga toxin type-2 and Subtilase cytotoxin on human microvascular endothelial cells. PLoS One, 8, 7, 1-11.
10.1371/journal.pone.0070431
2013 Plumptre, C., Ogunniyi, A. & Paton, J. (2013). Surface association of Pht proteins of Streptococcus pneumoniae. Infection and Immunity, 81, 10, 3644-3651.
10.1128/IAI.00562-13
2012 Athanasiou, D., Kosmaoglou, M., Kanuga, N., Novoselov, S., Paton, A., Paton, J. ... Cheetham, M. (2012). BiP prevents rod opsin aggregation. Molecular Biology of the Cell, 23, 18, 3522-3531.
10.1091/mbc.E12-02-0168
2012 Plumptre, C., Ogunniyi, A. & Paton, J. (2012). Polyhistidine triad proteins of pathogenic streptococci. Trends in Microbiology, 20, 10, 485-493.
10.1016/j.tim.2012.06.004
2012 Johno, H., Nakajima, S., Kato, H., Yao, J., Paton, A., Paton, J. ... Kitamura, M. (2012). Unfolded protein response causes a phenotypic shift of inflamed glomerular cells toward redifferentiation through dual blockade of Akt and Smad signaling pathways. American Journal of Pathology, 181, 6, 1977-1990.
10.1016/j.ajpath.2012.08.015
2012 Weber, M., Lambeck, S., Ding, N., Henken, S., Kohl, M., Deigner, H. ... Bauer, M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB Journal, 26, 6, 2424-2436.
10.1096/fj.11-191957
2012 Ray, R., de Ridder, G., Eu, J., Paton, A., Paton, J. & Pizzo, S. (2012). The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. Journal of Biological Chemistry, 287, 39, 32755-32769.
10.1074/jbc.M112.399808
2012 Potter, A., Trappetti, C. & Paton, J. (2012). Streptococcus pneumoniae uses glutathione to defend against oxidative stress and metal ion toxicity. Journal of Bacteriology, 194, 22, 6248-6254.
10.1128/JB.01393-12
2012 Schäsignuble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulucan, O. ... Zimmermann, R. (2012). Erratum: BiP-mediated closing of the Sec61 channel limits Ca 2+ leakage from the ER (The EMBO Journal (2012) 31 (3282-3296) DOI: 10.1038/emboj.2012.189). EMBO Journal, 31, 18, 3784-.
10.1038/emboj.2012.243
2012 Watts, R., Tan, C., Ulett, G., Carey, A., Totsika, M., Idris, A. ... Schembri, M. (2012). Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli. Journal of Infectious Diseases, 206, 8, 1242-1249.
10.1093/infdis/jis493
2012 Rogers, T., Thorpe, C., Paton, A. & Paton, J. (2012). Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga-toxigenic Escherichia coli O113:H21. Infection and Immunity, 80, 8, 2858-2867.
10.1128/IAI.00336-12
2012 Ogunniyi, A., Mahdi, L., Trappetti, C., Verhoeven, N., Mermans, D., Van der Hoek, M. ... Paton, J. (2012). Identification of genes that contribute to the pathogenesis of invasive Pneumococcal Disease by in vivo transcriptomic analysis. Infection and Immunity, 80, 9, 3268-3278.
10.1128/IAI.00295-12
2012 Eletto, D., Maganty, A., Eletto, D., Dersh, D., Makarewich, C., Biswas, C. ... Argon, Y. (2012). Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of Cell Science, 125, 20, 4865-4875.
10.1242/jcs.108928
2012 Schauble, N., Lang, S., Jung, M., Cappel, S., Schorr, S., Ulucan, O. ... Zimmerman, R. (2012). BiP-mediated closing of the Sec61 channel limits Ca²⁺ leakage from the ER. EMBO Journal, 31, 15, 3282-3296.
10.1038/emboj.2012.189
2012 Brumshagen, C., Maus, R., Bischof, A., Ueberberg, B., Bohling, J., Osterholzer, J. ... Maus, U. (2012). FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: Role of pneumolysin. Infection and Immunity, 80, 12, 4281-4290.
10.1128/IAI.00854-12
2012 Mahdi, L., Wang, H., Van der Hoek, M., Paton, J. & Ogunniyi, A. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. Journal of Clinical Investigation, 122, 6, 2208-2220.
10.1172/JCI45850
2012 Paton, A., Morona, R. & Paton, J. (2012). Bioengineered microbes in disease therapy. Trends in Molecular Medicine, 18, 7, 417-425.
10.1016/j.molmed.2012.05.006
2012 McAllister, L., Ogunniyi, A., Stroeher, U. & Paton, J. (2012). Contribution of a genomic accessory region encoding a putative cellobiose phosphotransferase system to virulence of Streptococcus Pneumoniae. PLoS One, 7, 2, 1-9.
10.1371/journal.pone.0032385
2011 Byrne, J., Morona, J., Paton, J. & Morona, R. (2011). Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation. Journal of Bacteriology, 193, 9, 2341-2346.
10.1128/JB.00074-11
2011 Wang, H., Paton, A., McColl, S. & Paton, J. (2011). In vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin. Infection and Immunity, 79, 4, 1671-1679.
10.1128/IAI.01204-10
2011 McDevitt, C., Ogunniyi, A., Valkov, E., Lawrence, M., Kobe, B., McEwan, A. & Paton, J. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7, 11, 2357-2365.
10.1371/journal.ppat.1002357
2011 Nakajima, S., Hiramatsu, N., Hayakawa, K., Saito, Y., Kato, H., Huang, T. ... Kitamura, M. (2011). Selective abrogation of BiP/GRP78 blunts activation of NF-κΒ through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt. Molecular and Cellular Biology, 31, 8, 1710-1718.
10.1128/MCB.00939-10
2011 Coats, M., Murphy, T., Paton, J., Gray, B. & Briles, D. (2011). Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A. Microbial Pathogenesis, 50, 6, 343-349.
10.1016/j.micpath.2011.02.010
2011 Goodwin, E., Lipovsky, A., Inoue, T., Magaldi, T., Edwards, A., Van Goor, K. ... DiMaio, D. (2011). BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio, 2, 3, e00101-1-e00101-9.
10.1128/mBio.00101-11
2011 Paton, J. & Ogunniyi, A. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host and Microbe, 9, 2, 89-91.
10.1016/j.chom.2011.01.013
2011 Harvey, R., Stroeher, U., Ogunniyi, A., Smith-Vaughan, H., Leach, A. & Paton, J. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One, 6, 5, 1-14.
10.1371/journal.pone.0019650
2011 McAllister, L., Ogunniyi, A., Stroeher, U., Leach, A. & Paton, J. (2011). Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infection and Immunity, 79, 12, 4839-4849.
10.1128/IAI.05663-11
2011 Zhang, H., Zhao, Y., Tian, T., Paton, A., Paton, J. & Kitamura, M. (2011). Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress. Analytical Biochemistry, 417, 2, 292-294.
10.1016/j.ab.2011.06.025
2011 Hahn, I., Klaus, A., Steinwede, K., Ding, N., Bohling, J., Serrano, H. ... Maus, U. (2011). Cathepsin G And Neutrophil Elastase Play Critical And Non-Redundant Roles In Lung Protective Immunity Against Streptococcus Pneumoniae In Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, -.
2011 Zhao, Y., Tian, T., Huang, T., Nakajima, S., Saito, Y., Takahashi, S. ... Kitamura, M. (2011). Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response. Toxicological Sciences, 120, 1, 79-86.
10.1093/toxsci/kfq368
2011 Steinwede, K., Tempelhof, O., Bolte, K., Maus, R., Bohling, J., Ueberberg, B. ... Maus, U. (2011). Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. Journal of Immunology, 187, 10, 5346-5356.
10.4049/jimmunol.1101413
2011 Harvey, R., Ogunniyi, A., Chen, A. & Paton, J. (2011). Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood. Infection and Immunity, 79, 10, 4122-4130.
10.1128/IAI.05418-11
2011 Tian, T., Zhao, Y., Nakajima, S., Huang, T., Yao, J., Paton, A. ... Kitamura, M. (2011). Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochemical and Biophysical Research Communications, 410, 4, 852-858.
10.1016/j.bbrc.2011.06.078
2011 van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J., Higgins, M., Deng, L. ... Boraston, A. (2011). The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure, 19, 5, 640-651.
10.1016/j.str.2011.03.001
2011 Hahn, I., Klaus, A., Janze, A., Steinwede, K., Ding, N., Bohling, J. ... Maus, U. (2011). Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective Immunity against Streptococcus pneumoniae in mice. Infection and Immunity, 79, 12, 4893-4901.
10.1128/IAI.05593-11
2011 Trappetti, C., Potter, A., Paton, A., Oggioni, M. & Paton, J. (2011). LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae. Infection and Immunity, 79, 11, 4550-4558.
10.1128/IAI.05644-11
2011 Trappetti, C., Ogunniyi, A., Oggioni, M. & Paton, J. (2011). Extracellular matrix formation enhances the ability of streptococcus pneumoniae to cause invasive disease. PLoS One, 6, 5, 1-17.
10.1371/journal.pone.0019844
2010 Zhang, Q., Bagrade, L., Clarke, E., Paton, J., Nunez, D. & Finn, A. (2010). Bacterial lipoproteins differentially regulate human primary and memory CD4+T and B cell responses to pneumococcal protein antigens through Toll-like receptor 2. Journal of Infectious Diseases, 201, 11, 1753-1763.
10.1086/652495
2010 Henken, S., Bohling, J., Ogunniyi, A., Paton, J., Salisbury, V., Welte, T. & Maus, U. (2010). Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumoniae serotypes. Antimicrobial Agents and Chemotherapy, 54, 8, 3155-3160.
10.1128/AAC.00310-10
2010 Martin, S., Hill, D., Paton, J., Paton, A., Birch-Machin, M., Lovat, P. & Redfern, C. (2010). Targeting GRP78 to enhance melanoma cell death. Pigment Cell & Melanoma Research, 23, 5, 675-682.
10.1111/j.1755-148X.2010.00731.x
2010 Ogunniyi, A., Mahdi, L., Jennings, M., McEwan, A., McDevitt, C., Van der Hoek, M. ... Paton, J. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192, 17, 4489-4497.
10.1128/JB.00064-10
2010 Beddoe, T., Paton, A., Le Nours, J., Rossjohn, J. & Paton, J. (2010). Structure, biological functions and applications of the AB5 toxins. Trends in Biochemical Sciences, 35, 7, 411-418.
10.1016/j.tibs.2010.02.003
2010 Henken, S., Bohling, J., Martens-Lobenhoffer, J., Paton, J., Ogunniyi, A., Briles, D. ... Maus, U. (2010). Efficacy profiles of Daptomycin for treatment of Iinvasive and noninvasive pulmonary infections with treptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 54, 2, 707-717.
10.1128/AAC.00943-09
2010 Herbold, W., Maus, R., Hahn, I., Ding, N., Srivastava, M., Christman, J. ... Maus, U. (2010). Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infection and Immunity, 78, 6, 2620-2630.
10.1128/IAI.01169-09
2010 Potter, A., Kidd, S., McEwan, A. & Paton, J. (2010). The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production. Journal of Bacteriology, 192, 15, 4063-4066.
10.1128/JB.00383-10
2010 Jandhyala, D., Rogers, T., Kane, A., Paton, A., Paton, J. & Thorpe, C. (2010). Shiga toxin 2 and Flagellin from Shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation. Infection and Immunity, 78, 7, 2984-2994.
10.1128/IAI.00383-10
2010 Paton, A. & Paton, J. (2010). Escherichia coli subtilase cytotoxin. Toxins, 2, 2, 215-228.
10.3390/toxins2020215
2010 Paton, A., Morona, R. & Paton, J. (2010). Bioengineered bugs expressing oligosaccharide receptor mimics: Toxin-binding probiotics for treatment and prevention of enteric infections. Bioengineered Bugs, 1, 3, 172-177.
10.4161/bbug.1.3.10665
2010 Nakajima, S., Saito, Y., Takahashi, S., Hiramatsu, N., Kato, H., Johno, H. ... Kitamura, M. (2010). Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response. Biochemical and Biophysical Research Communications, 397, 2, 176-180.
10.1016/j.bbrc.2010.05.069
2010 Wang, H., Paton, J., Thorpe, C., Bonder, C., Sun, W. & Paton, A. (2010). Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli. Journal of Infectious Diseases, 202, 9, 1415-1423.
10.1086/656534
2010 Paton, A., Morona, R. & Paton, J. (2010). Receptor-mimic probiotics: Potential therapeutics for bacterial toxin-mediated enteric diseases. Expert Review of Gastroenterology and Hepatology, 4, 3, 253-255.
10.1586/egh.10.30
2010 May, K., Paton, J. & Paton, A. (2010). Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak. Infection and Immunity, 78, 11, 4691-4696.
10.1128/IAI.00801-10
2009 Arevalo, M., Xu, Q., Paton, J., Hollingshead, S., Pichichero, M., Briles, D. ... Zeng, M. (2009). Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung. FEMS Immunology and Medical Microbiology, 55, 3, 346-351.
10.1111/j.1574-695X.2008.00518.x
2009 Buchkovich, N., Maguire, T., Paton, A., Paton, J. & Alwine, J. (2009). The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. Journal of Virology, 83, 22, 11421-11428.
10.1128/JVI.00762-09
2009 Herold, S., Paton, J. & Paton, A. (2009). Sab, a novel autotransporter of locus of enterocyte effacement-negative shiga-toxigenic escherichia coli O113:H21, Contributes to adherence and biofilm formation. Infection and Immunity, 77, 8, 3234-3243.
10.1128/IAI.00031-09
2009 Backer, J., Krivoshein, A., Hamby, C., Pizzonia, J., Gilbert, K., Ray, Y. ... Backer, M. (2009). Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. Neoplasia, 11, 11, 1165-1173.
10.1593/neo.09878
2009 Ogunniyi, A., Grabowicz, M., Mahdi, L., Cook, J., Gordon, D., Sadlon, T. & Paton, J. (2009). Pneumococcal histidine triad proteins are regulated by the Zn²⁺-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H. FASEB Journal, 2008, 3, 1-8.
10.1096/fj.08-119537
2009 Smith, R., Willett, R., Kudlyk, T., Pokrovskaya, I., Paton, A., Paton, J. & Lupashin, V. (2009). The COG complex, Rab6 and COPI define a novel golgi retrograde trafficking pathway that is exploited by SubAB toxin. Traffic, 10, 10, 1502-1517.
10.1111/j.1600-0854.2009.00965.x
2009 Winter, C., Herbold, W., Maus, R., Langer, F., Briles, D., Paton, J. ... Maus, U. (2009). Important Role for CC Chemokine Ligand 2-Dependent Lung Mononuclear Phagocyte Recruitment to Inhibit Sepsis in Mice Infected with Streptococcus pneumoniae. Journal of Immunology, 182, 8, 4931-4937.
10.4049/jimmunol.0804096
2009 Martner, A., Skovbjerg, S., Paton, J. & Wold, A. (2009). Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte-activating cytokines. Infection and Immunity, 77, 9, 3826-3837.
10.1128/IAI.00290-09
2009 Harama, D., Koyama, K., Mukai, M., Shimokawa, N., Miyata, M., Nakamura, Y. ... Nakao, A. (2009). A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. Journal of Immunology, 183, 2, 1368-1374.
10.4049/jimmunol.0804066
2009 Hayakawa, K., Hiramatsu, N., Okamura, M., Yamazaki, H., Nakajima, S., Yao, J. ... Kitamura, M. (2009). Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation. Journal of Immunology, 182, 2, 1182-1191.
10.4049/jimmunol.182.2.1182
2009 Huang, T., Wan, Y., Zhu, Y., Fang, X., Hiramatsu, N., Hayakawa, K. ... Yao, J. (2009). Downregulation of Gap Junction Expression and Function by Endoplasmic Reticulum Stress. Journal of Cellular Biochemistry, 107, 5, 973-983.
10.1002/jcb.22202
2009 Hu, C., Dougan, S., Winter, S., Paton, A., Paton, J. & Ploegh, H. (2009). Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. Journal of Experimental Medicine, 206, 11, 2429-2440.
10.1084/jem.20090782
2009 Newton, H., Sloan, J., Bulach, D., Seemann, T., Allison, C., Tauschek, M. ... Hartland, E. (2009). Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement. Emerging Infectious Diseases, 15, 3, 372-380.
10.3201/eid1502.080631
2009 Du, S., Hiramatsu, N., Hayakawa, K., Kasai, A., Okamura, M., Huang, T. ... Kitamura, M. (2009). Suppression of NF-kappa B by Cyclosporin A and Tacrolimus (FK506) via Induction of the C/EBP Family: Implication for Unfolded Protein Response. Journal of Immunology, 182, 11, 7201-7211.
10.4049/jimmunol.0801772
2009 Yamazaki, H., Hiramatsu, K., Hayakawa, K., Tagawa, Y., Okamura, M., Ogata, R. ... Kitamura, M. (2009). Activation of the Akt-NF-kappa B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response. Journal of Immunology, 183, 2, 1480-1487.
10.4049/jimmunol.0900017
2009 Rogers, T. & Paton, A. (2009). Therapeutic strategies for Shiga toxin-producing Escherichia coli infections. Expert Review of Anti-infective Therapy, 7, 6, 683-686.
10.1586/ERI.09.51
2009 Lofling, J., Paton, A., Varki, N., Paton, J. & Varki, A. (2009). A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome. Kidney International, 76, 2, 140-144.
10.1038/ki.2009.131
2009 Herold, S., Paton, J., Srimanote, P. & Paton, A. (2009). Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli. Microbiology, 155, 11, 3554-3563.
10.1099/mic.0.029454-0
2008 Takano, S., Ando, T., Hiramatsu, N., Kanayama, A., Maekawa, S., Ohnuma, Y. ... Nakao, A. (2008). T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochemical and Biophysical Research Communications, 371, 4, 762-766.
10.1016/j.bbrc.2008.04.132
2008 Taut, K., Winter, C., Briles, D., Paton, J., Christman, J., Maus, R. ... Maus, U. (2008). Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae. American Journal of Respiratory Cell and Molecular Biology, 38, 1, 105-113.
10.1165/rcmb.2007-0132OC
2008 Buchkovich, N., Maguire, T., Yu, Y., Paton, A., Paton, J. & Alwine, J. (2008). Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. Journal of Virology, 82, 1, 31-39.
10.1128/JVI.01881-07
2008 Martner, A., Dahlgren, C., Paton, J. & Wold, A. (2008). Pneumolysin released during Streptococcus pneumoniae autolysis is a potent activator of intracellular oxygen radical production in neutrophils. Infection and Immunity, 76, 9, 4079-4087.
10.1128/IAI.01747-07
2008 Okamura, M., Takano, Y., Hiramatsu, N., Hayakawa, K., Yao, J., Paton, A. ... Kitamura, M. (2008). Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response. American Journal of Physiology - Renal Physiology, 295, 5, F1495-F1503.
10.1152/ajprenal.00602.2007
2008 Chen, Q., Akiba, H., Paton, J. C., Cannons, J., Schwartzberg, P. L. & Snapper, C. (2008). The CD4+T cell- and SAP-dependent IgG anti-polysaccharide response to intact Streptococcus pneumoniae, in contrast to pneumococcal conjugate vaccine, is ICOS-independent. FASEB JOURNAL, 22, -.
2008 Wolfson, J., May, K., Thorpe, C., Jandhyala, D., Paton, J. & Paton, A. (2008). Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways. Cellular Microbiology, 10, 9, 1775-1786.
10.1111/j.1462-5822.2008.01164.x
2008 Lass, A., Kujawa, M., McConnell, E., Paton, A., Paton, J. & Wojcik, C. (2008). Decreased ER-associated degradation of alpha-TCR induced by Grp78 depletion with the SubAB cytotoxin. International Journal of Biochemistry & Cell Biology, 40, 12, 2865-2879.
10.1016/j.biocel.2008.06.003
2008 Ogunniyi, A., Paton, J., Kirby, A., McCullers, J., Cook, J., Hyodo, M. ... Karaolis, D. (2008). C-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine, 26, 36, 4676-4685.
10.1016/j.vaccine.2008.06.099
2008 Mahdi, L., Ogunniyi, A., Le Messurier, K. & Paton, J. (2008). Pneumococcal Virulence Gene Expression and Host Cytokine Profiles during Pathogenesis of Invasive Disease. Infection and Immunity, 76, 2, 646-657.
10.1128/IAI.01161-07
2008 Dessing, M., Florquin, S., Paton, J. & van der Poll, T. (2008). Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci. Cellular Microbiology, 10, 1, 237-246.
10.1111/j.1462-5822.2007.01035.x
2008 Kadioglu, A., Weiser, J., Paton, J. & Andrew, P. (2008). The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature Reviews. Microbiology, 6, 4, 288-301.
10.1038/nrmicro1871
2008 Hayakawa, K., Hiramatsu, N., Okamura, M., Yao, J., Paton, A., Paton, J. & Kitamura, M. (2008). Blunted activation of NF-kappa B and NF-kappa B-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response. Biochemical and Biophysical Research Communications, 365, 1, 47-53.
10.1016/j.bbrc.2007.10.115
2008 Chong, D., Paton, J., Thorpe, C. & Paton, A. (2008). Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB(5) toxin that targets the endoplasmic reticulum chaperone BiP. Cellular Microbiology, 10, 3, 795-806.
10.1111/j.1462-5822.2007.01085.x
2008 Bernatoniene, J., Zhang, Q., Dogan, S., Mitchell, T., Paton, J. & Finn, A. (2008). Induction of CC and CXC chemokines in human antigen‐presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by Toll‐Like receptor 4, NF‐κB, and mitogen‐activated protein kinases. Journal of Infectious Diseases, 198, 12, 1823-1833.
10.1086/593177
2008 Chen, Q., Cannons, J., Paton, J., Akiba, H., Schwartzberg, P. & Snapper, C. (2008). A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine. Journal of Immunology, 181, 12, 8258-8266.
10.4049/jimmunol.181.12.8258
2008 Byres, E., Paton, A., Paton, J., Lofling, J., Smith, D., Wilce, M. ... Beddoe, T. (2008). Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature, 456, 7222, 648-652.
10.1038/nature07428
2007 Stroeher, U., Kidd, S., Stafford, S., Jennings, M., Paton, J. & McEwan, A. (2007). A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence. Journal of Infectious Diseases, 196, 12, 1820-1826.
10.1086/523107
2007 Takano, Y., Hiramatsu, N., Okamura, M., Hayakawa, K., Shimada, T., Kasai, A. ... Kitamura, M. (2007). Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response. Biochemical and Biophysical Research Communications, 360, 2, 470-475.
10.1016/j.bbrc.2007.06.082
2007 Zhang, Q., Bagrade, L., Bernatoniene, J., Clarke, E., Paton, J., Mitchell, T. ... Finn, A. (2007). Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. Journal of Infectious Diseases, 195, 8, 1194-1202.
10.1086/512617
2007 Standish, A., Stroeher, U. & Paton, J. (2007). The pneumococcal two-component signal transduction system RR/HK06 regulates CbpA and PspA by two distinct mechanisms. Journal of Bacteriology, 189, 15, 5591-5600.
10.1128/JB.00335-07
2007 Maus, U., Backi, M., Winter, C., Srivastava, M., Schwarz, M., Ruckle, T. ... Preissner, K. (2007). Importance of phosphoinositide 3-kinase γ in the host defense against pneumococcal infection. American Journal of Respiratory and Critical Care Medicine, 175, 9, 958-966.
10.1164/rccm.200610-1533OC
2007 Ogunniyi, A., Le Messurier, K., Graham, R., Watt, J., Briles, D., Stroeher, U. & Paton, J. (2007). Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model. Infection and Immunity, 75, 4, 1843-1851.
10.1128/IAI.01384-06
2007 Pramanik, A., Stroeher, U., Krejci, J., Standish, A., Bohn, E., Paton, J. ... Braun, V. (2007). Albomycin is an effective antibiotic, as exemplified with Yersinia enterocolitica and Streptococcus pneumoniae. International Journal of Medical Microbiology, 297, 6, 459-469.
10.1016/j.ijmm.2007.03.002
2007 Wang, H., Paton, J. & Paton, A. (2007). Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB₅ toxin that targets the endoplasmic reticulum. Journal of Infectious Diseases, 196, 7, 1093-1101.
10.1086/521364
2007 Winter, C., Taut, K., Langer, F., Mack, M., Briles, D., Paton, J. ... Maus, U. (2007). FMS-Like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: Role of dendritic cells. Journal of Immunology, 179, 5, 3099-3108.
10.4049/jimmunol.179.5.3099
2007 Winter, C., Taut, K., Srivastava, M., Langer, F., Mack, M., Briles, D. ... Maus, U. (2007). Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host Defense to Streptococcus pneumoniae infection in mice: Role of the CCL2-CCR2 axis. Journal of Immunology, 178, 9, 5828-5838.
10.4049/jimmunol.178.9.5828
2007 Tu, L., Jeong, H., Kwon, H., Ogunniyi, A., Paton, J., Pyo, S. & Rhee, D. (2007). Modulation of adherence invasion and tumor necrosis factor alpha secretion during the early stages of infection by Strepococcus pneumoniae ClpL. Infection and Immunity, 75, 6, 2996-3005.
10.1128/IAI.01716-06
2007 Ogunniyi, A., Grabowicz, M., Briles, D., Cook, J. & Paton, J. (2007). Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infection and Immunity, 75, 1, 350-357.
10.1128/IAI.01103-06
2006 Morona, J., Morona, R. & Paton, J. (2006). Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease. Proceedings of the National Academy of Sciences of the United States of America, 103, 22, 8505-8510.
10.1073/pnas.0602148103
2006 Paton, A., Beddoe, T., Thorpe, C., Whisstock, J., Wilce, M., Rossjohn, J. ... Paton, J. (2006). AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature, 443, 7111, 548-552.
10.1038/nature05124
2006 Zhang, Q., Bernatoniene, J., Bagrade, L., Paton, J., Mitchell, T., Hammerschmidt, S. ... Finn, A. (2006). Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infection and Immunity, 74, 8, 4735-4743.
10.1128/IAI.00165-06
2006 Paton, A., Morona, R. & Paton, J. (2006). Treatment and Prevention of Enteric Infections With Toxin-binding Probiotics. Discovery Medicine, 6, 31, 35-39.
2006 Paton, A., Morona, R. & Paton, J. (2006). Designer probiotics for prevention of enteric infections. Nature Reviews. Microbiology, 4, 3, 193-200.
10.1038/nrmicro1349
2006 Graham, R. & Paton, J. (2006). Differential role of CbpA and PspA in modulation of in vitro CXC chemokine responses of respiratory epithelial cells to infection with Streptococcus pneumoniae. Infection and Immunity, 74, 12, 6739-6749.
10.1128/IAI.00954-06
2006 Rogers, T., Paton, J., Wang, H., Talbot, U. & Paton, A. (2006). Reduced virulence of an fliC mutant of Shiga-Toxigenic Escherichia coli O113 : H21. Infection and Immunity, 74, 3, 1962-1966.
10.1128/IAI.74.3.1962-1966.2006
2006 Paton, J. & Paton, A. (2006). Shiga toxin 'goes retro' in human primary kidney cells. Kidney International, 70, 12, 2049-2051.
10.1038/sj.ki.5001954
2006 Focareta, A., Paton, J., Morona, R., Cook, J. & Paton, A. (2006). A recombinant probiotic for treatment and prevention of cholera. Gastroenterology, 130, 6, 1688-1695.
10.1053/j.gastro.2006.02.005
2006 Zhang, Q., Bernatoniene, J., Bagrade, L., Pollard, A., Mitchell, T., Paton, J. & Finn, A. (2006). Serum and mucosal antibody respnses to pneumococcal protein antigens in children: relationships with carriage status. European Journal of Immunology, 36, 1, 46-57.
10.1002/eji.200535101
2006 Le Messurier, K., Ogunniyi, A. & Paton, J. (2006). Differential expression of key pneumococcal virulence genes in vivo. Microbiology, 152, 2, 305-311.
10.1099/mic.0.28438-0
2006 Manco, S., Hernon, F., Yesilkaya, H., Paton, J., Andrew, P. & Kadioglu, A. (2006). Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. Infection and Immunity, 74, 7, 4014-4020.
10.1128/IAI.01237-05
2005 Khan, A., Chen, Q., Wu, Z., Paton, J. & Snapper, C. (2005). Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2. Infection and Immunity, 73, 1, 298-307.
10.1128/IAI.73.1.298-307.2005
2005 Standish, A., Stroeher, U. & Paton, J. (2005). The two-component signal transduction system RR06/HK06 regulates expression of cbpA in Streptococcus pneumonia. Proceedings of the National Academy of Sciences of the United States of America, 102, 21, 7701-7706.
10.1073/pnas.0409377102
2005 Yuste, J., Botto, M., Paton, J., Holden, D. & Brown, J. (2005). Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. Journal of Immunology, 175, 3, 1813-1819.
10.4049/jimmunol.175.3.1813
2005 Srivastava, A., Henneke, P., Visintin, A., Morse, S., Martin, V., Watkins, C. ... Malley, R. (2005). The apoptotic response to pneumolysin is toll-like receptor 4 dependent and protects against pneumococcal disease. Infection and Immunity, 73, 10, 6479-6487.
10.1128/IAI.73.10.6479-6487.2005
2005 Paton, A., Jennings, M., Morona, R., Wang, H., Focareta, A., Roddam, L. & Paton, J. (2005). Recombinant probiotics for treatment and prevention of enterotoxigenic escherichia coli diarrhea. Gastroenterology, 128, 5, 1219-1228.
10.1053/j.gastro.2005.01.050
2005 Talbot, U., Paton, J. & Paton, A. (2005). Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli. Infection and Immunity, 73, 7, 4432-4436.
10.1128/IAI.73.7.4432-4436.2005
2005 Jomaa, M., Yuste, J., Paton, J., Jones, C., Dougan, G. & Brown, J. (2005). Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae. Infection and Immunity, 73, 10, 6852-6859.
10.1128/IAI.73.10.6852-6859.2005
2005 Paton, A. & Paton, J. (2005). Multiplex PCR for direct detection of Shiga toxigenic Escherichia coli strains producing the novel subtilase cytotoxin. Journal of Clinical Microbiology, 43, 6, 2944-2947.
10.1128/JCM.43.6.2944-2947.2005
2005 Palaniappan, R., Singh, S., Singh, U., Sakthivel, S., Ades, E., Briles, D. ... Lillard Jr., J. (2005). Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infection and Immunity, 73, 2, 1006-1013.
10.1128/IAI.73.2.1006-1013.2005
2004 Brown, J., Ogunniyi, A., Woodrow, M., Holden, D. & Paton, J. (2004). Erratum: Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection (Infection and Immunity (2001) 69, 11 (6702-6706)). Infection and Immunity, 72, 11, 6755-.
10.1128/IAI.72.11.6755.2004
2004 McAllister, L., Tseng, H., Ogunniyi, A., Jennings, M., McEwan, A. & Paton, J. (2004). Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Molecular Microbiology, 53, 3, 889-901.
10.1111/j.1365-2958.2004.04164.x
2004 Paton, A., Srimanote, P., Talbot, U., Wang, H. & Paton, J. (2004). Erratum: (Journal of Experimental Medicine (July 5, 2004) 200, 1 (35-46)). Journal of Experimental Medicine, 200, 11, 1525-.
10.1084/jem.20040392111204c
2004 Morona, J., Miller, D., Morona, R. & Paton, J. (2004). The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae. Journal of Infectious Diseases, 189, 10, 1905-1913.
10.1086/383352
2004 Maus, U., Srivastava, M., Paton, J., Mack, M., Everhart, M., Blackwell, T. ... Lohmeyer, J. (2004). Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. Journal of Immunology, 173, 2, 1307-1312.
10.4049/jimmunol.173.2.1307
2004 Pinyon, R., Paton, J., Paton, A., Botten, J. & Morona, R. (2004). Refinement of a therapeutic Shiga toxin-binding probiotic for human trials. Journal of Infectious Diseases, 189, 9, 1547-1555.
10.1086/383417
2004 Paton, A., Srimanote, P., Talbot, U., Wang, H. & Paton, J. (2004). A new family of potent AB5 cytotoxins produced by Shiga toxigenic Escherichia coli.. Journal of Experimental Medicine, 200, 1, 35-46.
10.1084/jem.20040392
2004 Kwon, H., Ogunniyi, A., Choi, M., Pyo, S., Rhee, D. & Paton, J. (2004). The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Infection and Immunity, 72, 10, 5646-5653.
10.1128/IAI.72.10.5646-5653.2004
2003 Briles, D., Hollingshead, S., Paton, J., Ades, E., Novak, L., van Ginkel, F. & Benjamin Jr, W. (2003). Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. Journal of Infectious Diseases, 188, 3, 339-348.
10.1086/376571
2003 Stroeher, U., Paton, A., Ogunniyi, A. & Paton, J. (2003). Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model. Infection and Immunity, 71, 6, 3206-3212.
10.1128/IAI.71.6.3206-3212.2003
2003 Rogers, T., Paton, A., McColl, S. & Paton, J. (2003). Enhanced CXC chemokine responses of human colonic epithelial cells to locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli. Infection and Immunity, 71, 10, 5623-5632.
10.1128/IAI.71.10.5623-5632.2003
2003 Jenkins, C., Perry, N., Cheasty, T., Shaw, D., Frankel, G., Dougan, G. ... Paton, J. (2003). Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins. Journal of Clinical Microbiology, 41, 4, 1775-1778.
10.1128/JCM.41.4.1775-1778.2003
2003 Morona, J., Morona, R., Miller, D. & Paton, J. (2003). Mutational analysis of the carboxy-terminal (YGX)4 repeat domain of CpsD, an autophosphorylating tyrosine kinase required for capsule biosynthesis in Streptococcus pneumoniae. Journal of Bacteriology, 185, 10, 3009-3019.
10.1128/JB.185.10.3009-3019.2003
2003 Chapuy-Regaud, S., Ogunniyi, A., Diallo, N., Huet, Y., Desnottes, J., Paton, J. ... Trombe, M. (2003). RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae. Infection and Immunity, 71, 5, 2615-2625.
10.1128/IAI.71.5.2615-2625.2003
2003 Malley, R., Henneke, P., Morse, S., Cieslewicz, M., Lipsitch, M., Thompson, C. ... Golenbock, D. (2003). Recognition of pneumolysin by toll-like receptor 4 confers resistance to pneumococcal infection. Proceedings of the National Academy of Sciences of the United States of America, 100, 4, 1966-1971.
10.1073/pnas.0435928100
2003 Kwon, H., Kim, S., Choi, M., Ogunniyi, A., Paton, J., Park, S. ... Rhee, D. (2003). Effect of heat shock and mutations in ClpL and ClpP on virulence gene expression in Streptococcus pneumoniae. Infection and Immunity, 71, 7, 3757-3765.
10.1128/IAI.71.7.3757-3765.2003
2002 Brown, J., Hussell, T., Gilliland, S., Holden, D., Paton, J., Ehrenstein, M. ... Botto, M. (2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proceedings of the National Academy of Sciences of the United States of America, 99, 26, 16969-16974.
10.1073/pnas.012669199
2002 Duthy, T., Ormsby, R., Giannakis, E., Ogunniyi, A., Stroeher, U., Paton, J. & Gordon, D. (2002). The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15. Infection and Immunity, 70, 10, 5604-5611.
10.1128/IAI.70.10.5604-5611.2002
2002 Giammarinaro, P. & Paton, J. (2002). Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae. Infection and Immunity, 70, 10, 5454-5461.
10.1128/IAI.70.10.5454-5461.2002
2002 Morona, J., Morona, R., Miller, D. & Paton, J. (2002). Streptococcus pneumoniae capsule biosynthesis protein CpsB is a novel manganese-dependent phosphotyrosine-protein phosphatase. Journal of Bacteriology, 184, 2, 577-583.
10.1128/JB.184.2.577-583.2002
2002 Paton, A. & Paton, J. (2002). Reactivity of convalescent-phase hemolytic-uremic syndrome patient sera with the megaplasmid-encoded TagA protein of Shiga toxigenic Escherichia coli O157. Journal of Clinical Microbiology, 40, 4, 1395-1399.
10.1128/JCM.40.4.1395-1399.2002
2002 Tseng, H., McEwan, A., Paton, J. & Jennings, M. (2002). Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress. Infection and Immunity, 70, 3, 1635-1639.
10.1128/IAI.70.3.1635-1639.2002
2002 Ogunniyi, A., Giammarinaro, P. & Paton, J. (2002). The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology, 148, Part 7, 2045-2053.
10.1099/00221287-148-7-2045
2002 Paton, A. & Paton, J. (2002). Direct detection and characterization of Shiga toxigenic Escherichia coli by multiplex PCR for stx1, stx2, eae, ehxA, and saa. Journal of Clinical Microbiology, 40, 1, 271-274.
10.1128/JCM.40.1.271-274.2002
2002 Srimanote, P., Paton, A. & Paton, J. (2002). Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli strains that are virulent for humans. Infection and Immunity, 70, 6, 3094-3100.
10.1128/IAI.70.6.3094-3100.2002
2001 Briles, D., Hollingshead, S., Nabors, G., Paton, J. & Brooks-Walter, A. (2001). The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae. Vaccine, 19, SUPPL. 1, S87-S95.
10.1016/S0264-410X(00)00285-1
2001 Balachandran, P., Hollingshead, S., Paton, J. & Briles, D. (2001). The autolylic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin. Journal of Bacteriology, 183, 10, 3108-3116.
10.1128/JB.183.10.3108-3116.2001
2001 Paton, A., Srimanote, P., Woodrow, M. & Paton, J. (2001). Characterization of Saa, a novel autoagglutinating adhesin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli strains that are virulent for humans. Infection and Immunity, 69, 11, 6999-7009.
10.1128/IAI.69.11.6999-7009.2001
2001 Paton, J., Rogers, T., Morona, R. & Paton, A. (2001). Oral administration of formaldehyde-killed recombinant bacteria expressing a mimic of the shiga toxin receptor protects mice from fatal challenge with shiga-toxigenic Escherichia coli. Infection and Immunity, 69, 3, 1389-1393.
10.1128/IAI.69.3.1389-1393.2001
2001 Brown, J., Ogunniyi, A., Gilliland, S., Woodrow, M., Holden, D. & Paton, J. (2001). Immunisation with ABC transporter proteins protects against Streptococcus pneumoniae infection. THORAX, 56, 26-26.
2001 Brown, J., Ogunniyi, A., Woodrow, M., Holden, D. & Paton, J. (2001). Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infection and Immunity, 69, 11, 6702-6706.
10.1128/IAI.69.11.6702-6706.2001
2001 Ogunniyi, A., Woodrow, M., Poolman, J. & Paton, J. (2001). Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA. Infection and Immunity, 69, 10, 5997-6003.
10.1128/IAI.69.10.5997-6003.2001
2001 Paton, J. & Giammarinaro, P. (2001). Genome-based analysis of pneumococcal virulence factors: the quest for novel vaccine antigens and drug targets. Trends in Microbiology, 9, 11, 515-518.
10.1016/S0966-842X(01)02207-7
2001 Paton, A., Morona, R. & Paton, J. (2001). Neutralization of shiga toxins Stx1, Stx2c, and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infection and Immunity, 69, 3, 1967-1970.
10.1128/IAI.69.3.1967-1970.2001
2000 Morona, J., Paton, J., Miller, D. & Morona, R. (2000). Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in Streptococcus pneumoniae. Molecular Microbiology, 35, 6, 1431-1442.
10.1046/j.1365-2958.2000.01808.x
2000 McKessar, S., Berry, A., Bell, J., Turnidge, J. & Paton, J. (2000). Genetic characterization of vanG, a novel Vancomycin resistance locus of Enterococcus faecalis. Antimicrobial Agents and Chemotherapy, 44, 11, 3224-3228.
10.1128/AAC.44.11.3224-3228.2000
2000 Ogunniyi, A., Folland, R., Briles, D., Hollingshead, S. & Paton, J. (2000). Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infection and Immunity, 68, 5, 3028-3033.
10.1128/IAI.68.5.3028-3033.2000
2000 Ogierman, M., Paton, A. & Paton, J. (2000). Up-Regulation of both Intimin and eae-independent adherence of Shiga toxigenic Escherichia coli O157 by ler and phenotypic impact of a naturally occurring ler mutation. Infection and Immunity, 68, 9, 5344-5353.
10.1128/IAI.68.9.5344-5353.2000
2000 Briles, D., Ades, E., Paton, J., Sampson, J., Carlone, G., Huebner, R. ... Hollingshead, S. (2000). Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infection and Immunity, 68, 2, 796-800.
10.1128/IAI.68.2.796-800.2000
2000 Berry, A. & Paton, J. (2000). Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulance proteins. Infection and Immunity, 68, 1, 133-140.
10.1128/iai.68.1.133-140.2000
2000 Rapola, S., Jantti, V., Haikala, R., Syrjanen, R., Carlone, G., Sampson, J. ... Kayhty, H. (2000). Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. Journal of Infectious Diseases, 182, 4, 1146-1152.
10.1086/315822
2000 Paton, A., Morona, R. & Paton, J. (2000). A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine, 6, 3, 265-270.
10.1038/73111
1999 Auzat, I., Chapuy-Regaud, S., Bras, G., Santos, D., Ogunniyi, A., Thomas, I. ... Trombe, M. (1999). The NADH oxidase of Streptococcus pneumoniae: Its involvement in competence and virulence. Molecular Microbiology, 34, 5, 1018-1028.
10.1046/j.1365-2958.1999.01663.x
1999 Palmen, R., Ogunniyi, A., Berroy, P., Larpin, S., Paton, J. & Trombe, M. (1999). Insertional mutation of orfD of the DCW cluster of Streptococcus pneumoniae attenuates virulence. Microbial Pathogenesis, 27, 6, 337-348.
10.1006/mpat.1999.0310
1999 Paton, A., Woodrow, M., Doyle, R., Lanser, J. & Paton, J. (1999). Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic- uremic syndrome. Journal of Clinical Microbiology, 37, 10, 3357-3361.
1999 Morona, J., Morona, R. & Paton, J. (1999). Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae. Journal of Bacteriology, 181, 11, 3599-3605.
1999 Morona, J., Morona, R. & Paton, J. (1999). Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types beloning to serogroup 19. Journal of Bacteriology, 181, 17, 5355-5364.
1999 Paton, A. & Paton, J. (1999). Direct detection of Shiga toxigenic Escherichia coli strains belonging to serogroups O111, O157, and O113 by multiplex PCR. Journal of Clinical Microbiology, 37, 10, 3362-3365.
1999 Claverys, J., Granadel, C., Berry, A. & Paton, J. (1999). Penicillin tolerance in Streptococcus pneumoniae, autolysis and the Psa ATP-binding cassette (ABC) manganese permease. Molecular Microbiology, 32, 4, 881-883.
10.1046/j.1365-2958.1999.01369.x
1999 Berry, A., Ogunniyi, A., Miller, D. & Paton, J. (1999). Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene. Infection and Immunity, 67, 2, 981-985.
1999 Morona, J., Miller, D., Coffey, T., Vindurampulle, C., Spratt, B., Morona, R. & Paton, J. (1999). Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F. Microbiology - UK, 145, 4, 781-789.
10.1099/13500872-145-4-781
1999 Lankinen, K., Ruutu, P., Nohynek, H., Lucero, M., Paton, J. & Leinonen, M. (1999). Pneumococcal pneumonia diagnosis by demonstration of pneumolysin antibodies in precipitated immune complexes. A study in 350 Philippine children with acute lower respiratory infection. Scandinavian Journal of Infectious Diseases, 31, 2, 155-161.
10.1080/003655499750006209
1999 Paton, A. & Paton, J. (1999). Molecular characterization of the locus encoding biosynthesis of the lipopolysaccharide O antigen of Escherichia coli serotype O113. Infection and Immunity, 67, 11, 5930-5937.
1998 Rubins, J., Paddock, A., Charboneau, D., Berry, A., Paton, J. & Janoff, E. (1998). Pneumolysin in pneumococcal adherence and colonization. Microbial Pathogenesis, 25, 6, 337-342.
10.1006/mpat.1998.0239
1998 Bell, J., Paton, J. & Turnidge, J. (1998). Emergence of vancomycin-resistant enterococci in Australia: Phenotypic and genotypic characteristics of isolates. Journal of Clinical Microbiology, 36, 8, 2187-2190.
1998 Paton, A., Manning, P., Woodrow, M. & Paton, J. (1998). Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity.. Infection and Immunity, 66, 11, 5580-5586.
1998 Lawrence, M., Pilling, P., Epa, V., Berry, A., Ogunniyi, A. & Paton, J. (1998). The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein. Structure, 6, 12, 1553-1561.
10.1016/S0969-2126(98)00153-1
1998 Alexander, J., Berry, A., Paton, J., Rubins, J., Andrew, P. & Mitchell, T. (1998). Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microbial Pathogenesis, 24, 3, 167-174.
10.1006/mpat.1997.0185
1998 Paton, J. & Paton, A. (1998). Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clinical Microbiology Reviews, 11, 3, 450-479.
1998 Pilling, P., Lawrence, M., Berry, A., Ogunniyi, A., Lock, R. & Paton, J. (1998). Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae. Acta Crystallographica Section D: Biological Crystallography, 54, 6 PART II, 1464-1466.
10.1107/S0907444998005812
1998 Paton, A. & Paton, J. (1998). Detection and characterization of shiga toxigenic escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfb(O111), and rfb(O157). Journal of Clinical Microbiology, 36, 2, 598-602.
1998 Rossjohn, J., Gilbert, R., Crane, D., Morgan, P., Mitchell, T., Rowe, A. ... Parker, M. (1998). The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. Journal of Molecular Biology, 284, 2, 449-461.
10.1006/jmbi.1998.2167
1998 Coffey, T., Enright, M., Daniels, M., Morona, J., Morona, R., Hryniewicz, W. ... Spratt, B. (1998). Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.. Molecular Microbiology, 27, 1, 73-83.
10.1046/j.1365-2958.1998.00658.x
1998 Paton, A., Voss, E., Manning, P. & Paton, J. (1998). Antibodies to lipopolysaccharide block adherence of shiga toxin-producing Escherichia coli to human intestinal epithelial (Henle 407) cells.. Microbial Pathogenesis, 24, 1, 57-63.
10.1006/mpat.1997.0172
1998 Paton, J. (1998). Novel pneumococcal surface proteins: role in virulence and vaccine potential.. Trends in microbiology, 6, 3, 85-87.
10.1016/S0966-842X(98)01220-7
1998 Voss, E., Paton, A., Manning, P. & Paton, J. (1998). Molecular analysis of shiga toxigenic Escherichia coli O111:H proteins which react with sera from patients with hemolytic-uremic syndrome.. Infection and Immunity, 66, 4, 1467-1472.
1997 Paton, A., Voss, E., Manning, P. & Paton, J. (1997). Shiga toxin-producing Escherichia coli isolates from cases of human disease show enhanced adherence to intestinal epithelial (Henle 407) cells. Infection and Immunity, 65, 9, 3799-3805.
1997 Paton, A., Voss, E., Manning, P. & Paton, J. (1997). Enhanced adherence of Shiga-like toxin-producing Escherichia coli isolates from cases of human disease to intestinal epithelial (Henle 407) cells. Infection and Immunity, 65, 3799-3805.
1997 Jureidini, K., Henning, P., AlAbbad, A., Keeley, S., Paton, J. & Paton, A. (1997). Outbreak of HUS associated with verotoxigenic E-coli and dry fermented sausage.. KIDNEY INTERNATIONAL, 51, 4, 1305-1305.
1997 Canvin, J., Paton, J., Boulnois, G., Andrew, P. & Mitchell, T. (1997). Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin. Microbial Pathogenesis, 22, 3, 129-132.
10.1006/mpat.1996.0098
1997 Morona, J., Morona, R. & Paton, J. (1997). Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biuosynthetic pathway. Molecular Microbiology, 23, 4, 751-763.
10.1046/j.1365-2958.1997.2551624.x
1997 Morona, J., Morona, R. & Paton, J. (1997). Molecular and Genetic Characterization of the Capsule Biosynthesis Locus Of Streptococcus pneumoniae Type 19B. Journal of Bacteriology, 179, 15, 4953-4958.
10.1128/jb.179.15.4953-4958.1997
1997 Paton, J., Berry, A. & Lock, R. (1997). Molecular analysis of putative pneumococcal virulence proteins. Microbial Drug Resistance, 3, 1, 1-10.
10.1089/mdr.1997.3.1
1997 Benton, K., Paton, J. & Briles, D. (1997). Differences in virulence for mice among Streptococcus pneumoniae strains of capsular types 2, 3, 4, 5, and 6 are not attributable to differences in pneumolysin production. Infection and Immunity, 65, 4, 1237-1244.
1997 Benton, K., Paton, J. & Briles, D. (1997). The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model. Microbial Pathogenesis, 23, 4, 201-209.
10.1006/mpat.1997.0150
1997 Paton, J. & Paton, A. (1997). Instability of a shiga toxin type 2 gene in Enterobacter cloacae [3]. Journal of Clinical Microbiology, 35, 7, 1917-.
1997 Paton, J., Morona, J. & Morona, R. (1997). Characterization of the Capsular Polysaccharide Biosynthesis Locus of Streptococcus pneumoniae Type 19F. Microbial Drug Resistance-Mechanisms Epidemiology and Disease, 3, 1, 89-99.
10.1089/mdr.1997.3.89
1996 Paton, J. (1996). The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae. Trends in Microbiology, 4, 3, 103-106.
10.1016/0966-842X(96)81526-5
1996 Talbot, U., Paton, A. & Paton, J. (1996). Uptake of Streptococcus pneumoniae by respiratory epithelial cells. Infection and Immunity, 64, 9, 3772-3777.
1996 Rubins, J., Charboneau, D., Fasching, C., Berry, A., Paton, J., Alexander, J. ... Janoff, E. (1996). Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia.. American journal of respiratory and critical care medicine, 153, 4 Pt 1, 1339-1346.
10.1164/ajrccm.153.4.8616564
1996 Paton, A. & Paton, J. (1996). Enterobacter cloacae producing a Shiga-like toxin II-related cytotoxin associated with a case of hemolytic-uremic syndrome. Journal of Clinical Microbiology, 34, 2, 463-465.
1996 Rubins, J., Charboneau, D., Fasching, C., Berry, A., Paton, J., Alexander, J. ... Janoff, E. (1996). Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. American Journal of Respiratory and Critical Care Medicine, 153, 4, 1339-1346.
1996 Berry, A., Lock, R. & Paton, J. (1996). Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the Nanb enzyme from recombinant Escherichia coli. Journal of Bacteriology, 178, 16, 4854-4860.
10.1128/jb.178.16.4854-4860.1996
1996 Paton, J. & Paton, A. (1996). Survival rate of mice after transient colonization with Escherichia coli clones carrying variant Shiga-like toxin type II operons. Microbial Pathogenesis, 20, 6, 377-383.
10.1006/mpat.1996.0035
1996 Paton, A., Ratcliff, R., Doyle, R., Seymour-Murray, J., Davos, D., Lanser, J. & Paton, J. (1996). Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli. Journal of Clinical Microbiology, 34, 7, 1622-1627.
1996 Lock, R., Zhang, Q., Berry, A. & Paton, J. (1996). Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin. Microbial Pathogenesis, 21, 2, 71-83.
10.1006/mpat.1996.0044
1996 Berry, A. & Paton, J. (1996). Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae. Infection and Immunity, 64, 12, 5255-5262.
1995 Canvin, J., Marvin, A., Sivakumaran, M., Paton, J., Boulnois, G., Andrew, P. & Mitchell, T. (1995). The Role of Pneumolysin and Autolysin in the Pathology of Pneumonia and Septicemia in Mice Infected with a Type 2 Pneumococcus. Journal of Infectious Diseases, 172, 1, 119-123.
10.1093/infdis/172.1.119
1995 Guildolin, A., Morona, J., Morona, R., Hansman, D. & Paton, J. (1995). Nucleotide sequence analysis of genes essential for production of Streptococcus pneumoniae type 19F capsular polysaccharide.. J. Ferretti, M. Gilmore, T. Klaenhammer & F. Brown (Eds.). Developments in biological standardization, 85, 267-271.
1995 Cameron, A., Beers, M., Walker, C., Rose, N., Anear, E., Manatakis, Z. ... Ratcliff, R. (1995). Community outbreak of hemolytic uremic syndrome attributable to Escherichia Coli O111:NM - South Australia, 1995. Mortality and Morbidity Weekly Review, 44, 29, 550-558.
1995 Rubins, J., Charboneau, D., Paton, J., Mitchell, T., Andrew, P. & Janoff, E. (1995). Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Journal of Clinical Investigation, 95, 1, 142-150.
10.1172/JCI117631
1995 Paton, A., Beutin, L. & Paton, J. (1995). Heterogeneity of the amino-acid sequences of Escherichia coli shiga-like toxin type-I operons. Gene, 153, 1, 71-74.
10.1016/0378-1119(94)00777-P
1995 Paton, A., Bourne, A., Manning, P. & Paton, J. (1995). Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons. Infection and Immunity, 63, 7, 2450-2458.
1995 Paton, A., Manning, P. & Paton, J. (1995). Increased oral virulence of Escherichia coli expressing a variant Shiga-like toxin type II operon is associated with both A subunit residues Met4 and Gly102. Microbial Pathgenesis, 19, 3, 185-191.
10.1006/mpat.1995.0057
1995 Berry, A., Alexander, J., Mitchell, T., Andrew, P., Hansman, D. & Paton, J. (1995). Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infection and Immunity, 63, 5, 1969-1974.
1995 Friedland, I., Paris, M., Hickey, S., Shelton, S., Olsen, K., Paton, J. & Mc Cracken, G. (1995). The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis. Journal of Infectious Diseases, 172, 3, 805-809.
10.1093/infdis/172.3.805
1994 Alexander, J., Lock, R., Peeters, C., Poolman, J., Andrew, P., Mitchell, T. ... Paton, J. (1994). Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infection and Immunity, 62, 12, 5683-5688.
1994 Morona, J., Guidolin, A., Morona, R., Hansman, D. & Paton, J. (1994). Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae. Journal of Bacteriology, 176, 14, 4437-4443.
10.1128/jb.176.14.4437-4443.1994
1994 Berry, A., Lock, R., Thomas, S., Rajan, D., Hansman, D. & Paton, J. (1994). Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli. Infection and Immunity, 62, 3, 1101-1108.
1994 Paton, A. & Paton, J. (1994). Characterization of IS1203, an insertion sequence in Escherichia coli 0111:H-. Gene, 150, 1, 67-70.
10.1016/0378-1119(94)90859-1
1994 Guidolin, A., Morona, J., Morona, R., Hansman, D. & Paton, J. (1994). Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F. Infection and Immunity, 62, 12, 5384-5396.
1994 Lee, C., Lock, R., Andrew, P., Mitchell, T., Hansman, D. & Paton, J. (1994). Protection of infant mice from challenge with Strptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide-pneumolysoid conjugate. Vaccine, 12, 10, 875-878.
10.1016/0264-410X(94)90028-0
1993 Paton, J. (1993). Pathogenesis of pneumococcal disease. Current Opinion in Infectious Diseases, 6, 3, 363-368.
1993 Paton, J., Morona, J., Harrer, S., Hansman, D. & Morona, R. (1993). Immunization of mice with Salmonella typhimurium C5 aroA expressing a genetically toxoided derivative of the pneumococcal toxin pneumolysin. Microbial Pathogenesis, 14, 2, 95-102.
10.1006/mpat.1993.1010
1993 Paton, A., Paton, J. & Manning, P. (1993). Polymerase chain reaction amplification, cloning and sequencing of variant escherichia coli Shiga-like toxin type II operons. Microbial Pathogenesis, 15, 1, 77-82.
10.1006/mpat.1993.1058
1993 Paton, A., Paton, J., Goldwater, P. & Manning, P. (1993). Direct detection of Escherichia coli Shiga-like toxin genes in primary fecal cultures by polymerase chain reaction. Journal of Clinical Microbiology, 31, 11, 3063-3067.
1993 Paton, J., Andrew, P., Boulnois, G. & Mitchell, T. (1993). Molecular analysis of the pathogenicity of Streptococcus pneumoniae: The role of pneumococcal proteins. Annual Review of Microbiology, 47, 1, 89-115.
10.1146/annurev.mi.47.100193.000513
1993 Paton, A., Paton, J., Goldwater, P., Heuzenroeder, M. & Manning, P. (1993). Sequence of a variant Shiga-like toxin type-I operon of Eschirichia coli 0111:H-. Gene, 129, 1, 87-92.
10.1016/0378-1119(93)90700-D
1992 Paton, A., Paton, J., Lawrence, A., Goldwater, P. & Harris, R. (1992). Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by reverse transcription and polymerase chain reaction amplification. Journal of Clinical Microbiology, 30, 4, 901-904.
1992 Paton, A., Paton, J., Heuzenroeder, M., Goldwater, P. & Manning, P. (1992). Cloning and nucleotide sequence of a variant Shiga-like toxin II gene from Escherichia coli OX3:H21 isolated from a case of sudden infant death syndrome. Microbial Pathogenesis, 13, 3, 225-236.
10.1016/0882-4010(92)90023-H
1992 Berry, A., Paton, J. & Hansman, D. (1992). Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3. Microbial Pathogenesis, 12, 2, 87-93.
10.1016/0882-4010(92)90111-Z
1992 Lock, R., Hansman, D. & Paton, J. (1992). Comparative efficacy of autolysin and pneumolysin as immunogens protecting mice against infection by Streptococcus pneumoniae. Microbial Pathogenesis, 12, 2, 137-143.
10.1016/0882-4010(92)90116-6
1991 Paton, J., Lock, R., Lee, C., Li, J., Berry, A., Mitchell, T. ... Boulnois, G. (1991). Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infection and Immunity, 59, 7, 2297-2304.
1991 Boulnois, G., Paton, J., Mitchell, T. & Andrew, P. (1991). Structure and function of pneumolysin, the multifunctional, thiol‐activated toxin of Streptococcus pneumoniae. Molecular Microbiology, 5, 11, 2611-2616.
10.1111/j.1365-2958.1991.tb01969.x
1990 Mitchell, T., Mendez, F., Paton, J., Andrew, P. & Boulnois, G. (1990). Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2. Nucleic Acids Research, 18, 13, 4010-.
10.1093/nar/18.13.4010
1990 Glare, E., Paton, J., Premier, R., Lawrence, A. & Nisbet, I. (1990). Analysis of a repetitive DNA sequence from Bordetella pertussis and its application to the diagnosis of pertussis using the polymerase chain reaction. Journal of Clinical Microbiology, 28, 9, 1982-1987.
1990 Jalonen, E., Taira, S., Paton, J., Kerttula, Y., Suomalainen, P. & Leinonen, M. (1990). Pneumolysin, produced in Bacillus subtilis as antigen in enzyme immunoassay for etiological diagnosis of pneumococcal pneumonia. Serodiagnosis and Immunotherapy in Infectious Disease, 4, 6, 459-468.
10.1016/0888-0786(90)90059-W
1989 Berry, A., Glare, E., Hansman, D. & Paton, J. (1989). Presence of a small plasmid in clinical isolates of Streptococcus pneumoniae. FEMS Microbiology Letters, 65, 3, 275-278.
10.1111/j.1574-6968.1989.tb03673.x
1989 Taira, S., Jalonen, E., Paton, J., Sarvas, M. & Runeberg-Nyman, K. (1989). Production of pneumolysin, a pneumococcal toxin, in Bacillus subtilis. Gene, 77, 2, 211-218.
10.1016/0378-1119(89)90069-3
1989 Berry, A., Glare, E., Hansman, D. & Paton, J. (1989). Presence of a small plasmid in clinical isolates of Streptococcus pneumoniae. FEMS Microbiology Letters, 65, 3, 275-278.
10.1111/j.1574-6968.1989.tb03673.x
1989 Goldwater, P. & Paton, J. (1989). Apparent non-involvement of prions in the pathogenesis of spongiform change in HIV-infected brain. Journal of Neuropathology and Experimental Neurology, 48, 2, 184-186.
10.1097/00005072-198903000-00005
1989 Berry, A., Yother, J., Briles, D., Hansman, D. & Paton, J. (1989). Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infection and Immunity, 57, 7, 2037-2042.
1989 Berry, A., Lock, R., Hansman, D. & Paton, J. (1989). Contribution of autolysin to virulence of Streptococcus pneumoniae. Infection and Immunity, 57, 8, 2324-2330.
1989 Jalonen, E., Paton, J., Koskela, M., Kerttula, Y. & Leinonen, M. (1989). Measurement of antibody responses to pneumolysin-A promising method for the presumptive aetiological diagnosis of pneumococcal pneumonia. Journal of Infection, 19, 2, 127-134.
10.1016/S0163-4453(89)91864-1
1988 Berry, A., Paton, J., Glare, E., Hansman, D. & Catcheside, D. (1988). Cloning and expression of the pneumococcal neuraminidase gene in Escherichia coli. Gene, 71, 2, 299-305.
10.1016/0378-1119(88)90046-7
1988 Lock, R., Paton, J. & Hansman, D. (1988). Purification and immunological characterization of neuraminidase produced by Streptococcus pneumoniae. Microbial Pathogenesis, 4, 1, 33-43.
10.1016/0882-4010(88)90046-0
1988 Lock, R., Paton, J. & Hansman, D. (1988). Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae. Microbial Pathogenesis, 5, 6, 461-467.
10.1016/0882-4010(88)90007-1
1987 Lawrence, A. & Paton, J. (1987). Efficacy of enzyme-linked immunosorbent assay for rapid diagnosis of Bordetella pertussis infection. Journal of Clinical Microbiology, 25, 11, 2102-2104.
1986 Paton, J., Berry, A., Lock, R., Hansman, D. & Manning, P. (1986). Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infection and Immunity, 54, 1, 50-55.
1986 Nandoskar, M., Ferrante, A., Bates, E., Hurst, N. & Paton, J. (1986). Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin. Immunology, 59, 4, 515-520.
1986 Douglas, R., Hansman, D., Miles, H. & Paton, J. (1986). Pneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy children. American Journal of Diseases of Children, 140, 11, 1183-1185.
10.1001/archpedi.1986.02140250109044
1986 Paton, J., Toogood, I., Cockington, R. & Hansman, D. (1986). Antibody response to pneumococcal vaccine in children aged 5 to 15 years. American Journal of Diseases of Children, 140, 2, 135-138.
10.1001/archpedi.1986.02140160053031
1984 Paton, J., Rowan Kelly, B. & Ferrante, A. (1984). Activation of human complement by the pneumococcal toxin pneumolysin. Infection and Immunity, 43, 3, 1085-1087.
1984 Ferrante, A., Rowan-Kelly, B. & Paton, J. (1984). Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infection and Immunity, 46, 2, 585-589.
1983 Paton, J., Lawrence, A. & Steven, I. (1983). Quantities of Clostridium botulinum organisms and toxin in feces and presence of Clostridium botulinum toxin in the serum of an infant with botulism. Journal of Clinical Microbiology, 17, 1, 13-15.
1983 Paton, J., Lock, R. & Hansman, D. (1983). Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infection and Immunity, 40, 2, 548-552.
1983 Douglas, R., Paton, J., Duncan, S. & Hansman, D. (1983). Antibody response to pneumococcal vaccination in children younger than five years of age. Journal of Infectious Diseases, 148, 1, 131-137.
10.1093/infdis/148.1.131
1983 Paton, J. & Ferrante, A. (1983). Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infection and Immunity, 41, 3, 1212-1216.
1982 Paton, J., Lawrence, A. & Manson, J. (1982). Quantitation of Clostridium botulinum organisms and toxin in the feces of an infant with botulism. Journal of Clinical Microbiology, 15, 1, 1-4.
1980 Paton, J., May, B. & Elliott, W. (1980). Cerulenin inhibits production of extracellular proteins but not membrane proteins in Bacillus amyloliquefaciens. Journal of General Microbiology, 118, 1, 179-187.
1980 PATON, J. C., MAY, B. K. & ELLIOTT, W. H. (1980). CERULENIN INHIBITS PRODUCTION OF EXTRACELLULAR PROTEINS BUT NOT MEMBRANE-PROTEINS IN BACILLUS-AMYLOLIQUEFACIENS. JOURNAL OF GENERAL MICROBIOLOGY, 118, MAY, 179-187.
1980 Douglas, H., Manson, J., Paton, J., Hansman, D., Murrell, W. & Stewart, B. (1980). Infant botulism.. Medical Journal of Australia, 2, 7, 398-.
1979 PATON, J. & ELLIOTT, W. (1979). FATTY-ACID SYNTHESIS IS REQUIRED FOR EXTRACELLULAR PROTEIN SECRETION BY BACILLUS AMYLOLIQUEFACIENS. PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 12, 109-109.
1978 Paton, J., McMurchie, E., May, B. & Elliott, W. (1978). Effect of growth temperature on membrane fatty acid composition and susceptibility to cold shock of Bacillus amyloliquefaciens. Journal of Bacteriology, 135, 3, 754-759.
1978 PATON, J., MAY, B. & ELLIOTT, W. (1978). PHOSPHOLIPID ASYMMETRY IN MEMBRANE OF BACILLUS-AMYLOLIQUEFACIENS. PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 11, 107-107.
1978 Paton, J., May, B. & Elliott, W. (1978). Membrane phospholipid asymmetry in Bacillus amyloliquefaciens. Journal of Bacteriology, 135, 2, 393-401.

Book Chapters

Year Citation
2016 McDevitt, C., Begg, S. & Paton, J. (2016). Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae. In F. de Burjin (Ed.), Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (pp. 1184-1193). Hoboken, NJ, USA: John Wiley & Sons, Inc..
10.1002/9781119004813.ch115
2015 Ogunniyi, A. D. & Paton, J. C. (2015). Vaccine Potential of Pneumococcal Proteins. In J. S. Brown, S. Hammerschmidt & C. J. Orihuela (Eds.), Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions (pp. 59-78). United Kingdom: Elsevier.
10.1016/B978-0-12-410530-0.00004-1
2013 Ogunniyi, A. & Paton, J. (2013). Regulation of pneumococcal surface proteins and capsule. In M. Vasil & A. Darwin (Eds.), Regulation of Bacterial Virulence (pp. 190-208). United States: American Society for Microbiology Press.
2011 Paton, J. (2011). Vaccines against Streptococcus pneumoniae. In R. Rappuoli & F. Bagnoli (Eds.), Vaccine Design: Innovative Approaches and Novel Strategies (pp. 303-327). United Kingdom: Caister Academic Press.
2011 Paton, A., Morona, R. & Paton, J. (2011). Designer Probiotics and Enteric Cytoprotection. In J. J. Malago, J. F. J. G. Koninkx & R. Marinsek Logar (Eds.), Probiotic Bacteria and Enteric Infections: Cytoprotection by Probiotic Bacteria (pp. 429-444). Netherlands: Springer.
10.1007/978-94-007-0386-5
2011 Cox, D., Strudwick, N., Ali, A., Paton, A., Paton, J. & Schroder, M. (2011). Measuring signaling by the unfolded protein response. In P. Conn (Ed.), Methods in Enzymology - Volume 491 - The Unfolded Protein Response and Cellular Stress, Part C (pp. 261-292). United States: Elsevier.
10.1016/B978-0-12-385928-0.00015-8
2009 Paton, A. & Paton, J. (2009). Subtilase Cytotoxin- a new bacterial AB5 toxin family. In Thomas Proft (Ed.), Microbial Toxins: Current Research and Future Trends (pp. 81-91). Norfolk, UK: Caister Academic Press.
2007 Paton, J. & Morona, J. (2007). Pneumococcal capsular polysaccharides: biosynthesis and regulation. In R. Hakenbeck, C. Hakenbeck & S. Chhatwal (Eds.), The Molecular Biology of Streptococci (pp. 119-139). UK: Horizon Scientific Press.
2006 Briles, D., Paton, J., Swiatlo, E. & Crain, M. (2006). Pneumococcal Vaccines. In V. Fischetti, R. Novick, J. Ferretti, D. Portnoy & J. Rood (Eds.), Gram-positive pathogens (pp. 289-298). 1752 N St, NW, Washington, DC 20036-2904: American Society for Microbiology Press.
2006 Paton, J. & Morona, J. (2006). Streptococcus pneumoniae Capsular Polysaccharide. In V. A. Fischetti, R. P. Novick, J. F. Ferretti, D. A. Portnoy & J. I. Rood (Eds.), Gram-positive pathogens (pp. 241-252). 1752 N St, NW, Washington, DC 20036-2904: American Society for Microbiology Press.
2004 Paton, J. (2004). New pneumoccoccal vaccines: basic science developmnents. In E. Tuomanen, T. Mitchell, D. Morrison & B. Spratt (Eds.), The Pneumococcus (pp. 382-400). Washington DC, USA: American Society for Microbiology Press.
2004 Briles, D., Hollingshead, S. & Paton, J. (2004). Pneumoccoccal common proteins and other vaccine strategies. In M. Levine, J. Kaper, R. Rappuoli, M. Liu & M. Good (Eds.), New Generation Vaccines (pp. 459-469). New York, USA: Marcel Dekker Inc.
2003 Paton, J. & Paton, A. (2003). Methods for detection of STEC in humans: An overview. In D. Philpott & F. Ebel (Eds.), E. Coli Shiga Toxin Methods and Protocols (pp. 9-26). Totowa, New Jersey, USA: Humana Press.
2003 Paton, J. & Briles, D. (2003). Streptococcus pneumoniae vaccines. In R. Ellis & B. Brodeur (Eds.), New Bacterial Vaccines (pp. 294-310). Georgetown, Texas, USA: Landes Bioscience.
2003 Paton, A. & Paton, J. (2003). Detection and Characterizationn of STEC in Stool Samples Using PCR. In D. Philpott & F. Ebel (Eds.), E. Coli Shiga Toxin Methods and Protocols (pp. 45-54). Totowa, New Jersey, USA: Humana Press.
2001 Paton, J. (2001). Whooping Cough. In Laboratory Diagnosis of Bacterial Infections (pp. 687-703). New York: Marcel Dekker Inc.
2000 Paton, J. & Morona, J. (2000). Streptococcus pneumoniae Capsular Polysaccharide. In Gram-positive pathogens (pp. 201-213).

Conference Papers

Year Citation
2015 Knippenberg, S., Ueberberg, B., Maus, R., Bohling, J., Ding, N., Tarres, M. T. ... Maus, U. (2015). Streptococcus Pneumoniae Triggers Progression Of Pulmonary Fibrosis Through Pneumolysin. International Conference of the American-Thoracic-Society (ATS). Denver, CO.
2008 Herold, S., Paton, J. C. & Paton, A. W. (2008). Gastrointestinal short chain fatty acids affect iha expression in Shiga toxigenic Escherichia coli O113 : H21 strain 98NK2. 60th Annual Meeting of the Deutschen-Gesellschaft-fur-Hygiene-und-Mikrobiologie. Dresden, GERMANY.
2005 Khan, A. Q., Chen, Q. Y., Wu, Z. Q., Paton, J. C. & Snapper, C. M. (2005). Innate and type 1 humoral immunity to Streptococcus pneumoniae are both mediated by MyD88, but differ in their relative dependence on Toll-like receptor 2. Experimental Biology 2005 Meeting/35th International Congress of Physiological Sciences. San Diego, CA.
2003 Palaniappan, R., Singh, S., Singh, U. P., Briles, D. E., Hollingshead, S. K., Paton, J. C. ... Lillard, J. W. (2003). Role of RANTES in pneumococcal immunopathogenesis. 90th Annual Meeting of the American-Association-for-Immunologists. DENVER, COLORADO.
2003 Palaniappan, R., Briles, D. E., Hollingshead, S. K., Paton, J. C., Ades, E. W. & Lillard, J. W. (2003). CCR5 and PsaA-specific correlates of clinical pneurnococcal immunity. 90th Annual Meeting of the American-Association-for-Immunologists. DENVER, COLORADO.
1994 ANDREW, P., CANVIN, J., PATON, J., BOULNOIS, G. & MITCHELL, T. (1994). USE OF ISOGENIC MUTANTS TO INVESTIGATE THE ROLE OF PNEUMOLYSIN AND AUTOLYSIN IN PNEUMOCOCCAL INFECTION. 6th European Workshop on Bacterial Protein Toxins. J. Freer, R. Aitken, J. Alouf, G. Boulnois, P. Falmagne, F. Fehrenbach ... B. Witholt (Eds.) STIRLING, SCOTLAND.
1994 PATON, A. W. & PATON, J. C. (1994). NATURALLY OCCURRING SEQUENCE VARIATION IN A CATALYTICALLY-IMPORTANT REGION OF AN SLT-II A SUBUNIT GENE FROM ESCHERICHIA-COLI 0111-H-. 2nd International Symposium and Workshop on Verocytotoxin (Shiga-like toxin)-producing Escherichia Coli infections. M. A. Karmali & A. G. Goglio (Eds.) BERGAMO, ITALY.
1994 ANDREW, P. W., BOULNOIS, G. J., MITCHELL, T. J., LEE, C. J., PATON, J. C., POOLMAN, J. T. & PEETERS, C. C. A. M. (1994). PNEUMOCOCCAL VACCINES. 6th European Workshop on Bacterial Protein Toxins. J. Freer, R. Aitken, J. E. Alouf, G. Boulnois, P. Falmagne, F. Fehrenbach ... B. Witholt (Eds.) STIRLING, SCOTLAND.
1993 MITCHELL, T. J., ANDREW, P. W., BOULNOIS, G. J., LEE, C. J., LOCK, R. A. & PATON, J. C. (1993). MOLECULAR STUDIES OF PNEUMOLYSIN, THE THIOL-ACTIVATED TOXIN OF STREPTOCOCCUS PNEUMONIAE AS AN AID TO VACCINE DESIGN. 5TH EUROPEAN WORKSHOP ON BACTERIAL PROTEIN TOXINS. B. Witholt, J. E. Alouf, G. J. Boulnois, P. Cossart, B. W. Dijkstra, P. Falmagne ... H. Niemann (Eds.) VELDHOVEN, NETHERLANDS.
1993 ANDREW, P., CANVIN, J., MITCHELL, T., BOULNOIS, G. & PATON, J. (1993). STUDIES ON GENETICALLY ENGINEERED TOXOIDS ON PNEUMOLYSIN AND CONJUGATES OF PNEUMOLYSIN TOXOID AND PNEUMOCOCCAL POLYSACCHARIDE. 5TH EUROPEAN WORKSHOP ON BACTERIAL PROTEIN TOXINS. B. Witholt, J. Alouf, G. Boulnois, P. Cossart, B. Dijkstra, P. Falmagne ... H. Niemann (Eds.) VELDHOVEN, NETHERLANDS.

Conference Items

Year Citation
2016 Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R. ... McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. BioMetals 2016. Dresden, Germany.
2016 Tang, C., Chang, S., Paton, A., Paton, J., Gabrilovich, D., Ploegh, H. ... Hu, C. (2016). Specific serine phosphorylation of IRE-1 controls enhanced splicing of XBP-1 and RIDD. Annual Meeting of the American-Society-for-Cell-Biology (ASCB). San Francisco, CA.
2015 Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C. & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. An exchange workshop on antimicrobial resistance. UniSA.
2015 Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C. & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC.
2013 Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C. & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. School of Molecular and Biomedical Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. Faculty of Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology BD Student Award.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. Adelaide Protein Group.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. ABC2012 – 4th FEBS Special Meeting on ABC Proteins.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology Scientific Meeting.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. ASBMB ComBio.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. School of Molecular and Biomedical Sciences Postgraduate Symposium.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Adelaide Protein Group.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. School of Molecular and Biomedical Science Research Symposium.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Australian Society for Medical Research SA Meeting.
2008 Morona, J. K., Morona, R. & Paton, J. C. (2008). Comparison of Streptococcus pneumoniae Polysaccharide Polymerase Proteins Cps19aI and Cps19fI. FASEB Summer Research Conferences: Microbial Polysaccharides of Medical, Agricultural and Industrial Importance. Carefree, Arizona, USA.
2007 Morona, J. K., Morona, R. & Paton, J. C. (2007). Comparison of Streptococcus pneumoniae Polysaccharide Polymerase Proteins Cps19aI and Cps19fI. Ninth Australian Conference on Molecular Biology of Bacterial Pathogens. Lorne, Victoria, Australia.
2006 Morona, J. K., Morona, R. & Paton, J. C. (2006). Mutation of the Conserved Capsular Polysaccharide Biosynthesis Gene cpsB of Streptococcus pneumoniae D39 results in two distinct CPS phenotypes.. The 5th International Symposium on Pneumococci and Pneumococcal Diseases. Alice Springs, Northern Territory, Australia.
2000 Morona, J. K., Morona, R., Miller, D. C. & Paton, J.C., (2000). Mutation analysis of the carboxy-terminal [YGX]4 repeat domain of CpsD, a Streptococcus pneumoniae capsule biosynthesis protein. FASEB Summer Research Conferences: Microbial Polysaccharides of Medical, Agricultural and Industrial Importance. Copper Mountain, Colorado, USA.
1999 Morona, J. K., Morona, R. & Paton, J. C. (1999). Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19. Fifth Australian Conference on Molecular Analysis of Bacterial Pathogens. Victor Harbor, SA., Australia.
1998 Paton, J. C., Morona, J. K. & Morona, R. (1998). Characterisation of the capsule biosynthesis loci of pneumococci belonging to serogroup 19. First International symposium on Pneumococci and pneumococcal Diseases. Elsinore, Denmark.
1997 Paton, J. C., Morona, J. K. & Morona, R. (1997). Molecular analysis of capsular polysaccharide biosynthesis (cps) loci of Streptococcus pneumoniae.. Australian Society for Microbiology, Annual Scientific Meeting. Adelaide, Australia.
1997 Morona, J. K., Morona, R. & Paton, J. C. (1997). Molecular and genetic characterisation of the capsule biosynthesis locus of Streptococcus pneumoniae type 19B. Fourth Australian Conference on Molecular Analysis of Bacterial Pathogens. Jamberoo, NSW. Australia.
1994 Guidolin, A., Morona, J. K., Morona, R., Hansman, D. & Paton, J. C. (1994). Analysis of genes essential for the production of Streptococcus pneumoniae type 19F capsular polysaccharide. Am. Soc. Microbiol. Fourth Int. Conf. Streptoccocal Genet. Sante Fe, New Mexico, USA.
1994 Guidolin, A., Morona, J. K., Morona, R., Hansman, D. & Paton, J. C. (1994). Nucleotide sequence of genes essential for production of Streptococcus pneumoniae type 19F capsular polysaccharide. Australian Society for Microbiology, Annual Scientific Meeting. Melbourne, Australia.
1983 Douglas, R. M., Paton, J. C., Miles, H., Duncan, S. J. & Hansman, D. (1983). Antibody response of young children to pneumococcal vaccination. Combined Meeting of the Royal College of Pathologists of Australasia and the New Zealand Society of Pathologists. Dunedin, New Zealand.
10.1016/S0031-3025(16)38165-X

Patents

Year Citation
2015 Alsharifi, M., Babb, R., Chen, A. Y., Hirst, T. R., Ogunniyi, A. D. & Paton, J. C.; (2015); Streptococcal Vaccine;
2013 Paton, J. C. & Paton, A.; (2013); Cleavage of BiP by Subtilase Cytotoxin;
2010 Paton, J., Morona, R. & Paton, A.; (2010); Cytotoxin with a Subtilase Domain;
2008 Paton, A., Paton, J., Backer, M. & Backer, J.; (2008); Cleavage of BiP by Subtilase Cytotoxin;
2006 Paton, A. & Paton, J.; (2006); Cytotoxin with a subtilase domain;
2006 Paton, A., Morono, R. & Paton, J.; (2006); Recombinant microorganisms expressing an oligosaccharide receptor mimic;
2006 Paton, A., Morona, R. & Paton, J.; (2006); Recombinant bacterium expressing an oligosaccharide receptor mimic;
2005 Rhee, D. K., Kwon, H. Y., Choi, M. H., Ogunniyi, A. & Paton, J.; (2005); Vaccine comprising recombinant CIpP protein of streptococcus Pneumoniae;
2005 Paton, A., Paton, J. & Morona, R.; (2005); Treatment and prevention of enterotoxigenic escherichia coli diarrhoeas;
2004 Paton, A. & Paton, J.; (2004); Cytotoxin with a subtilase domain;

Investigators

Year

Granting Body

Title of Project

Amount

 

 

 

 

 

R.M. Douglas,J.C. Paton, D. Hansman

 

1981

Merck, Sharp & Dohme Research Laboratories

Antibody response to pneumo-coccal vaccine in Adelaide children.

$8,500

J.C. Paton, D. Hansman

 

 

1982

NHMRC

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

$22,500

J.C. Paton, D. Hansman

 

 

1982

ACH Research Foundation

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

$3,500

I. Toogood, J.C. Paton, D. Hansman

 

1983

ACH Research Foundation

Antibody response to pneumococcal vaccination in children with Thalassemia major.

$6,100

J.C. Paton, D. Hansman

 

 

1983

ACH Research Foundation

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

$3,535

J.C. Paton, D. Hansman

 

 

1983-5

NHMRC

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

$88,266

J.C. Paton, D. Hansman

 

 

1985-6

ACH Research Foundation

Cloning of pneumolysin for development of an improved pneumococcal vaccine.

$48,000

J.C. Paton, D. Hansman

1985-6

ACH Research Foundation

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

 

$36,490

J.C. Paton, A. Lawrence

 

 

 

1986

Channel 10 Children’s Medical Research Foundation

Cloning of Bordetella pertussis virulence determinants as an aid in the diagnosis and prevention of whooping cough.

$10,000

J.C. Paton, D. Hansman

 

 

1987-9

NHMRC

The molecular basis for the pathogenicity of Streptococcus pneumoniae.

$176,407

J.C. Paton

 

 

1987-9

NHMRC

Cloning of Bordetella pertussis virulence determinants.

$98,955

J.C. Paton, D. Hansman

 

1988

ACH Research Foundation

Molecular analysis of pneumococcal virulence.

$8,000

J.C. Paton, P. Goldwater, M. Heuzenroeder

 

1990

ACH Research Foundation

Molecular biological analysis of toxigenic E. coli isolated from cases of SIDS.

$25,000

J.C. Paton, D. Hansman

 

1990-2

NHMRC

Molecular analysis of pneumococcal virulence.

$217,778

J.C. Paton, R. Morona, D. Hansman

 

1990-3

WHO Program for Vaccine Development

Development of an oral pneumococcal vaccine based on recombinant Salmonellae.

$143,750

J.C. Paton, R.J. Harris, P. Goldwater

 

 

1990-1

Channel 7 Children’s Research Foundation

Rapid diagnosis of respiratory infections using the polymerase chain reaction.

$15,000

J.C. Paton, R. Morona, D. Hansman

 

1991-3

NHMRC

Development of an oral pneumococcal vaccine based on recombinant Salmonellae.

$100,373

J.C. Paton, D. Hansman

 

1991

ACH Research Foundation

Molecular analysis of pneumococcal pathogenesis.

$10,000

J.C. Paton, M. Heuzenroeder, P. Goldwater

 

1991

ACH Research Foundation

Molecular biological analysis of toxigenic E. coli isolated from cases of SIDS.

$10,000

J.C. Paton, M. Heuzenroeder, P. Goldwater

 

1991

Sudden Infant Death Research Foundation

Molecular biological analysis of toxigenic E. coli isolated from cases of SIDS.

$30,000

J.C. Paton, R.J. Harris, P. Goldwater

 

1991

ACH Research Foundation

Rapid diagnosis of respiratory infections using the polymerase chain reaction.

$10,000

J.C. Paton

1991

NHMRC

New Brunswick Fermentor (Special Equipment Grant).

 

$26,435

J.C. Paton, G. Boulnois

 

1992-4

RIVM

(Netherlands Inst. for Public Health)

 

Development of pneumolysoid-polysaccharide conjugate vaccine.

$876,568

J.C. Paton

 

 

1992

NHMRC

Production of vaccine antigens (Special Equipment Grant).

$30,000

J.C. Paton, D. Hansman

 

1992

ACH Research Foundation

ACH Research Foundation

$12,420

J.C. Paton, M. Heuzenroeder, P. Goldwater

 

1992

ACH Research Foundation

Molecular biological analysis of toxigenic E. coli isolated from cases of SIDS.

$7,200

J.C. Paton, M. Heuzenroeder, P. Goldwater

 

1992-3

Sudden Infant Death Research Foundation

Molecular biological analysis of toxigenic E. coli isolated from cases of SIDS.

$70,000

J.C. Paton, P. Goldwater

 

 

1993

ACH Research Foundation

Rapid diagnosis of respiratory infections using the polymerase chain reaction.

$20,000

J.C. Paton,  D. Hansman

 

1993-5

NHMRC

Molecular analysis of pneumococcal pathogenesis.

$262,883

J.C. Paton

 

1994

NHMRC

Refrigerated centrifuge (equipment Grant).

$20,000

J.C. Paton

 

 

1994

WCH Research Foundation

Analysis of Shiga-like toxin genes of E. coli.

$35,000

A. Guidolin, J.C. Paton

 

 

1994

WCH Research Foundation

Cloning and analysis of the genes encoding pneumococcal capsule production.

$30,000

J.C. Paton, T. Mitchell, P. Andrew

 

1995

RIVM (Netherlands Inst. for Public Health)

 

Development of a pneumolysoid-polysaccharide conjugate vaccine.

$244,856

J.C. Paton, R. Morona, D. Hansman

 

1995-7

NHMRC

Cloning and analysis of the genes encoding pneumococcal capsule production.

$192,506

J.C. Paton, A.W. Paton

 

 

1995

WCH Research Foundation

Role of Escherichia coli Shiga-like toxins in the pathogenesis of human disease.

$35,000

J.C. Paton, R. Morona

 

 

 

1995

WHO Program for Vaccine Development

Development of an oral pneumococcal vaccine based on Salmonellae expressing pneumolysin derivatives.

$33,731

J.C. Paton, A.W. Paton

 

 

 

1995-7

Channel 7 Children’s Research Foundation

Molecular analysis of virulence factors of group B streptococci.

$80,000

J.C. Paton

1996-8

NHMRC

Molecular analysis of pneumococcal pathogenesis.

 

$315,753

J.C. Paton, P.A. Manning

1996-8

NHMRC

Pathogenesis of Shiga-like toxin-producing Escherichia coli (SLTEC) infection.

 

$221,623

J.C. Paton

1997

NHMRC

Programmable thermal cycler (Special Equipment Grant).

 

$18,000

J.C. Paton

1997

University of Adelaide, Faculty of Medicine

 

Molecular analysis of virulence factors of group B streptococci.

$10,000

J.C. Paton, R. Morona

 

1998-2000

NHMRC

Cloning and analysis of the genes encoding pneumococcal capsule production.

 

$300,734

J.C. Paton

1998-2000

NHMRC

 

Molecular analysis of virulence factors of group B streptococci.

 

$175,354

J.C. Paton, D.E. Briles

 

 

1998-9

WHO Program for Vaccine Development

Development of pneumococcal common protein vaccine.

$120,000

J.C. Paton

1998

Ramaciotti Foundation

Molecular analysis of bacterial pathogenesis: high speed refrigerated centrifuge.

 

$13,000

J.C. Paton, A.D. Ogunniyi

1999

WCH Research

Foundation

Regulation of capsule expression in Streptococcus pneumoniae.

 

$30,000

J.C. Paton

1999

Smith-Kline Beecham

Passive immunization against Streptococcus pneumoniae.

 

$22,000

J.C. Paton

1999-2001

NHMRC

Molecular analysis of pneumococcal pathogenesis.

 

$396,515

J.C. Paton, A.W. Paton

1999-2001

NHMRC

Pathogenesis of Shiga-toxigenic Escherichia coli (STEC) infection.

 

$382,633

J.C. Paton, A.W. Paton, R. Morona

1999-2000

Channel 7 Children’s Research Foundation

Recombinant bacteria expressing a Shiga toxin receptor analogue: a probiotic approach to the prevention of HUS in children.

 

$35,000

J.C. Paton

1999

Smith-Kline Beecham

Novel pneumococcal vaccine antigens.

 

$27,000

J. C. Paton

1999-2000

RIVM (Netherlands Inst. for Public Health)

 

Identification of novel candidate pneumococcal vaccine antigens.

$160,000

J.C. Paton, A.W. Paton, R. Morona

2000

WCH Research

Foundation

Recombinant bacteria expressing a Shiga toxin receptor analogue: a probiotic approach to the prevention of HUS in children.

 

$40,000

A.D. Ogunniyi, J.C. Paton

2000

WCH Research

Foundation

Regulation of capsule expression in Streptococcus pneumoniae.

 

$40,000

J.C. Paton

2000-1

Adelaide University B3

Pathogenesis of group B streptococcal infections.

 

$25,000

J.C. Paton

2001-3

NHMRC

Molecular analysis of  virulence factors of group B streptococci.

 

$211,527

J.C. Paton, R. Morona

2001-3

NHMRC

Genetic analysis of polysaccharide capsule biosynthesis and regulation in Streptococcus pneumoniae.

 

$377,036

A.W. Paton, R. Morona, J.C. Paton

2001

Adelaide University B1

Recombinant bacteria expressing oligosaccharide receptor mimics for treatment and prevention of enteric infections.

 

$12,000

A.W. Paton, R. Morona, J.C. Paton

2001-2

Neose Technologies, Philadelphia, USA.

Recombinant bacteria expressing oligosaccharide receptor mimics for treatment and prevention of enteric infections

 

$388,756

J.C. Paton, A.W. Paton, R. Morona

 

2002

Florey Medical Research Fund

Recombinant bacteria expressing oligosaccharide receptor mimics for treatment of enteric infections.

$100,000

J.C. Paton, A.W. Paton, R. Morona

2002-4

Australian Research Council

Recombinant probiotics for prevention of enteric infections in piglets.

 

$215,972

J.C. Paton

2002-4

NHMRC

Molecular analysis of pneumococcal pathogenesis.

 

$480,000

J.C. Paton, A.W. Paton

2002-4

NHMRC

Pathogenesis of Shiga-toxigenic Escherichia coli (STEC) infection.

 

$510,000

J.C. Paton

2002-4

Meningitis Research Foundation (UK)

Characterization of Streptococcus pneumoniae virulence factors and development of a protein-based vaccine.

 

$272,450

J.C. Paton, A.W. Paton, R. Morona

2003-5

NHMRC Development Grant

Recombinant bacteria expressing oligosaccharide receptor mimics for treatment of enteric infections.

 

$451,056

M.P. Jennings, A.G. McEwan, J.C. Paton

 

2003-5

NHMRC

Oxidative stress and virulence in Streptococcus pneumoniae.

$315,000

J.I Rood, B. Adler, J. Davies, E. Hartland, M. Jennings, A. McEwan, R. Morona, J.C. Paton, A.W. Paton, R. Robins-Browne, R. Strugnell

 

2004-8

NHMRC Program Grant

The molecular basis of bacterial infectious diseases

$16,230,995

 

($4,500,000 for my laboratory)

R. Curtiss III, C. Raetz, H.Y. Kang, S. Hollingshead, J.C. Paton, D.E. Briles, A. Camilli, R. Strugnell, O. Wijburg, M. Cunningham, S. Frey, J. Clemens, A. Tagliabue, S. Kweon

2006-2011

Bill and Melinda Gates Foundation and National Institutes of Health; Grand Challenges in Global Health

A live recombinant attenuated Salmonella anti-pneumococcal vaccine for newborns.

US$ $14,800,000

 

(»AU$660,000 for my laboratory)

A.W. Paton, J.C. Paton, J. Rossjohn

 

 

 

2006-2011

NIH [1R01AI068715-01]

Characterization of a novel AB5 cytotoxin.

US$1,250,000

AU$1.4 mil

J.C. Paton, E.I. Tuomanen, D.E. Briles

2008-2010

PATH Vaccine Solutions

Trivalent pneumococcal protein vaccine: Preclinical optimization, GMP production and Phase I US trial

 

US$588,000

AU$650K

D.E. Briles, J.C. Paton, E.I. Tuomanen

2008-2010

PATH Vaccine Solutions

Pneumococcal vaccine candidates: Efficacy tests in animals

US$759,700

 

AU$840K

 

A.D. Ogunniyi, J.C. Paton, L.K. Mahdi

2008-2011

Meningitis Research Foundation (UK)

Characterization and vaccine potential of pneumococcal virulence factors expressed during meningitis.

 

UK£196,773

 

»AU$437K

J.C. Paton

2007-2012

 

NHMRC

Australia Fellowship

$4,000,000

JK Morona, GW Booker, R Morona, JC Paton

2008

Channel 7 Children’s Medical Research Foundation

Treatment and/or prevention of pneumococcal disease by designing novel drugs targeting capsule biosynthesis proteins CpsB and CpsD

$50,417

 

 

 

 

 

A.W. Paton, J.C. Paton,

2009-2012

NHMRC

Virulence strategies of LEE-negative Shiga toxigenic Escherichia coli.

 

$744,455

A.G. McEwan, M.P. Jennings, J.C. Paton

 

2009-2011

NHMRC

The molecular physiology of Streptococcus pneumoniae during sepsis.

$568,135

CJ Sumby, JA Carver, JC Wallace, M Hrmova, A Pring, AD Abell, GW Booker, MI Bruce, J Brugger, CM Ford, HH Harris, JC Morris, JC Paton, DJ Peet, SM Pyke, KE Shearwin, RI Menz, CA Abbott, PA Anderson, MH Brown, MR Johnston, KA Schuller, AF Lopez, SM Pitson, SF Lincoln, RA McKinnon

 

2009

ARC LIEF

South Australian Facility for Small and Large Molecule X-Ray Diffraction Structure Determination

$560,000

JC Paton, R Morona, AW Paton, AD Ogunniyi, A Jilbert, SR McColl

 

2008

NHMRC Equipment Grant

Facility for in vivo transcriptional analysis of the host-pathogen interaction

$61,000

A. Cooper, D.L. Adelson, B.W. Brook, J.M. Facelli, H.B. Cross, M.I. Stevens, J.C. Paton, T. Kok

2009-2011

ARC Linkage

Environmental genomics: mining, climate change, water, crime and health.

$500,000

J.C. Paton, M.P. Jennings, B. Kobe, A.G. McEwan, R. Morona, A.W. Paton, M.J. Walker

 

2010-2014

NHMRC Program Grant

Pathogenesis, treatment and prevention of bacterial infectious diseases.

$9,427,155

($4.1 million for Adelaide)

J.C. Paton, A.D. Ogunniyi

 

2010-2014

NHMRC Project Grant

Molecular analysis of pneumococcal pathogenesis.

$1,068,030

R. Morona, J.C. Paton, A.W. Paton, C.A. McDevitt

 

2009

NHMRC Equipment Grant

Bacterial cell lysis system

$27,000

A. Lopez, S. Kumar, T. Hughes, H. Scott, G. Goodall, W. Tilley, S. McColl, J.C. Paton, D. Adelson, J. Gecz, J. Melo, B. To.

 

2010

Australian Cancer Research Foundation

South Australian Cancer Genome Facility

$3,500,000

A.W. Paton, R. Morona, J.C. Paton

 

2010-2011

Bill and Melinda Gates Foundation Grand Challenge Explorations

 

A toxin-binding probiotic for prevention of ETEC diarrhea.

US$100,000

(AU$110K)

C.A. McDevitt, J.C. Paton, A.W. Paton, R. Morona, J.C. Wallace, G. Booker

 

2011

NHMRC Equipment Grant

Ultracentrifuge

$78,000

J.C. Paton.

 

2012-2014

ARC Discovery Grant DP120101432

 

Functional characterization of poly-histidine triad proteins.

 

$275,000

C.A. McDevitt, J.C. Paton.

 

2012-2014

ARC Discovery Grant DP120103957

 

The molecular basis for bacterial susceptibility to zinc.

 

$255,000

             

 

 

C.A. McDevitt, J.C. Paton, A.W. Paton, R. Morona, K.E. Shearwin, A. Chapman-Smith, B. Forbes, A.D. Abell.

 

2011

NHMRC Equipment Grant

Temperature controlled protein purification system

$62,042

J.C. Paton, A.D. Ogunniyi, M. Alsharifi, T. Hirst

 

2012-2015

ARC Linkage Grant LP120200244

A single vaccine for influenza and pneumonia.

$276,000

J.C. Paton

2013-2017

NHMRC

Senior Principal Research Fellowship

 

$808,375

J.C. Paton, M.P. Jennings, M. von Itzstein, B. Kobe, M.J. Walker

 

2015-2019

NHMRC Program Grant

Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines.

$8,795,785

 

J.C. Paton, C.A. McDevitt

2015-2017

ARC Dicovery Grant DP150104515

 

The critical role of bacterial poly-histidine triad proteins in zinc recruitment.

$384,300

TOTAL

 

 

 

$79,822,851

 

 

 

 

 

Position
Australian Fellow
Phone
83135929
Fax
8313 3262
Campus
North Terrace
Building
Molecular Life Sciences
Room Number
4 11
Org Unit
Molecular and Cellular Biology

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