Grant-Funded Researcher (B)
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
I am the current recipient of the Veronika Sacco Clinical Cancer Research Fellowship in the Myeloma Research Laboratory, Adelaide Medical School, University of Adelaide based in the Cancer Theme at the South Australian Health and Medical Research Institute (SAHMRI).
I completed my PhD through the University of Adelaide in December 2011, with a thesis entitled “An Investigation of mutant p53 function”. In 2012, I began work as a post-doctoral researcher in the Myeloma Research Laboratory where my research interests have centred on the role of the bone marrow microenvironment in the development and progression of Multiple Myeloma.
Myeloma is a haematological malignancy that is characterised by the clonal proliferation of plasma cells within the bone marrow. Myeloma is the second most common blood cancer, and is responsible for approximately 80,000 deaths worldwide each year. Although significant advances have been made in the treatment of myeloma in recent years, almost all patients will eventually relapse. My current research interests revolve around investigating the role of the bone marrow microenvironment in the development and progression of myeloma.
Myeloma develops almost exclusively within the bone marrow of patients, wherein myeloma plasma cells colonise discrete niches adjacent to bone and interact with cells of the bone marrow stroma. Stromal cells of the bone marrow niche have been well documented to support the pathogenesis of both primary and metastatic tumours, including myeloma. However, the identity of the cells within the bone marrow microenvironment that are essential for MM development remain to be determined. My primary research interest focuses on identifying a role for bone resident macrophages in mediating myeloma development with the aim of developing novel therapeutic strategies to target the bone microenvironment to limit disease progression.
Current Projects include:
- Investigation of the role of the bone marrow microenvironment in the development of myeloma
- Identification of bone resident macrophage populations involved in mediating myeloma development
Date Position Institution name 2013 - ongoing Postdoctoral Fellow University of Adelaide 2012 - 2013 Postdoctoral Research Scientist, Grant Funded SA Pathology 2011 - 2012 Research Officer University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2013 Fellowship Veronika Sacco Clinical Cancer Research Fellowship, Florey Foundation University of Adelaide Australia 2013 Award School of Medical Sciences, University of Adelaide, Travel Grant University of Adelaide Australia 2013 Award SAHMRI Beat Cancer Project Travel Grant South Australian Health & Medical Sciences Institute Australia
Date Institution name Country Title 2008 - 2011 University of Adelaide Australia Doctor of Philosophy (PhD) 2007 - 2007 University of Adelaide Australia Bachelor of Health Science (Honours) First Class 2004 - 2006 University of Adelaide Australia Bachelor of Science (Biomedical Science)
Year Citation Noll, J. E., Vandyke, K., & Zannettino, A. C. W. (n.d.). The Role of the “Cancer Stem Cell Niche” in Cancer Initiation and Progression. In Adult Stem Cell Niches. InTech.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Investigating mechanisms of relapse in high-risk paediatric pre-B-cell acute lymphoblastic leukaemia Master of Philosophy (Medical Science) Master Full Time Mr Caleb Ben Lill 2021 Co-Supervisor The Role of Myeloperoxidase in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mr Connor Maxwell Douglas Williams 2021 Co-Supervisor Investigating the role of Gremlin1 in driving multiple myeloma cancer development and progression Doctor of Philosophy Doctorate Full Time Miss Emma Anna-Jane Cheney
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2021 Co-Supervisor Macrophages, Myeloma, Mouse Models and Methodologies Doctor of Philosophy Doctorate Full Time Mrs Khatora Shanae Opperman
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2017 - ongoing Co-Supervisor Investigating the role of resident bone macrophages in Multiple Myeloma University of Adelaide Doctor of Philosophy Doctorate Full Time Khatora Said 2016 - 2016 Co-Supervisor An insight into the myeloma niche: a novel role for bone marrow-resident macrophages in multiple myeloma University of Adelaide Honours Full Time Khatora Said 2015 - 2016 Co-Supervisor Internship Saxion University of Applied Science, The Netherlands Other Full Time Tamara Scheffer
Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2018 - ongoing Manucsript Reviewer Peer Review OncoTargets and Therapy 2016 - ongoing Manuscript Reviewer Peer Review Medical Oncology Australia 2016 - ongoing Manuscript Reviewer Peer Review Molecular Cancer Therapeutics and Seminars in Cell and Developmental Biology Australia
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