Jack Da Silva

Dr Jack Da Silva

Senior Lecturer

School of Biological Sciences

Faculty of Sciences


My research and teaching are focused on evolutionary genetics. Current topics of interest are:

evolution of sex and recombination
evolution of sexes (anisogamy)
evolution of senescence (ageing)
evolution of eusociality

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  • Journals

    Year Citation
    2020 da Silva, J. (2020). Williams’ Intuition about Extrinsic Mortality Was Correct. Trends in Ecology and Evolution, 35(5), 378-379.
    DOI WoS1
    2019 da Silva, J. (2019). Plastic senescence in the honey bee and the disposable soma theory. The American Naturalist, 194(3), 367-380.
    DOI Scopus1 WoS2 Europe PMC1
    2019 da Silva, J. (2019). Correction: Plastic senescence in the honeybee and the disposable soma theory (American Naturalist, 194, 3, (2019), (367-380), 10.1086/704220). American Naturalist, 194(6), 881-884.
    DOI
    2018 da Silva, J. (2018). The evolution of sexes: A specific test of the disruptive selection theory. Ecology and Evolution, 8(1), 207-219.
    DOI Scopus7 WoS9 Europe PMC5
    2018 da Silva, J. (2018). Reports of the Death of Extrinsic Mortality Moulding Senescence Have Been Greatly Exaggerated. Evolutionary Biology, 45(2), 140-143.
    DOI Scopus4 WoS4
    2018 Da Silva, J., & Drysdale, V. (2018). Isogamy in large and complex volvocine algae is consistent with the gamete competition theory of the evolution of anisogamy. Proceedings of the Royal Society B: Biological Sciences, 285(1890), 6 pages.
    DOI Scopus4 WoS6 Europe PMC4
    2017 da Silva, J., & Galbraith, J. (2017). Hill-Robertson interference maintained by Red Queen dynamics favours the evolution of sex. Journal of Evolutionary Biology, 30(5), 994-1010.
    DOI Scopus3 WoS4 Europe PMC3
    2014 Da Silva, J., & Wyatt, S. (2014). Fitness valleys constrain HIV-1's adaptation to its secondary chemokine coreceptor. Journal of Evolutionary Biology, 27(3), 604-615.
    DOI Scopus8 WoS9 Europe PMC6
    2012 Da Silva, J. (2012). Antibody selection and amino acid reversions. Evolution, 66(10), 3079-3087.
    DOI WoS1 Europe PMC1
    2012 Da Silva, J. (2012). BRCA1/2 mutations, fertility and the grandmother effect. Royal Society of London. Proceedings B. Biological Sciences, 279(1740), 2926-2929.
    DOI Scopus5 WoS6 Europe PMC3
    2012 Da Silva, J. (2012). The dynamics of HIV-1 adaptation in early infection. Genetics, 190(3), 1087-1099.
    DOI Scopus13 WoS13 Europe PMC12
    2010 Da Silva, J., Coetzer, M., Nedellec, R., Pastore, C., & Mosier, D. (2010). Fitness epistasis and constraints on adaptation in a human immunodeficiency virus Type 1 protein region. Genetics, 185(1), 293-303.
    DOI Scopus90 WoS93 Europe PMC81
    2010 Da Silva, J. (2010). An adaptive walk by human immunodeficiency virus type 1 through a fluctuating fitness landscape. Evolution, 64(4), 1160-1165.
    DOI Scopus2 WoS2 Europe PMC2
    2009 Da Silva, J. (2009). Amino acid covariation in a functionally important human immunodeficiency virus type 1 protein region is associated with population subdivision. Genetics, 182(1), 265-275.
    DOI Scopus3 WoS3 Europe PMC3
    2009 Summers, K., Roney, K., Da Silva, J., Capraro, G., Cuthbertson, B., Kazianis, S., . . . McConnell, T. (2009). Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes. Genetica, 135(3), 379-390.
    DOI Scopus5 WoS7 Europe PMC6
    2006 Da Silva, J. (2006). Site-specific amino acid frequency, fitness and the mutational landscape model of adaptation in human immunodeficiency virus type 1. Genetics, 174(3), 1689-1694.
    DOI Scopus11 WoS10 Europe PMC10
    2003 Da Silva, J. (2003). The evolutionary adaptation of HIV-1 to specific immunity. Current HIV Research, 1(3), 363-371.
    DOI Scopus20 WoS21 Europe PMC15
    2002 Summers, K., Da Silva, J., & Farwell, M. (2002). Intragenomic conflict and cancer. Medical Hypotheses, 59(2), 170-179.
    DOI Scopus17 WoS18 Europe PMC15
    2002 Burke Da Silva, K., Mahan, C., & Da Silva, J. (2002). The Trill of the Chase: Eastern Chipmunks call to warn kin. Journal of Mammalogy, 83(2), 546-552.
    DOI Scopus15 WoS14
    2001 Hughes, A., Westover, K., Da Silva, J., O'Connor, D., & Watkins, D. (2001). Simultaneous positive and purifying selection on overlapping reading frames of the tat and vpr genes of Simian Immunodeficiency Virus. Journal of Virology, 75(17), 7966-7972.
    DOI Scopus56 WoS58 Europe PMC46
    2001 Ferguson, M., Maxwell, J., Vincent, T., Da Silva, J., & Olson, J. (2001). Comparison of the exoS gene and protein expression in soil and clinical isolates of pseudomonas aeruginosa. Infection and Immunity, 69(4), 2198-2210.
    DOI Scopus36 WoS39 Europe PMC28
    2001 Hughes, A., Da Silva, J., & Friedman, R. (2001). Ancient genome duplications did not structure the human Hox-bearing chromosomes. Genome Research, 11(5), 771-780.
    DOI Scopus100 WoS92 Europe PMC76
    1999 Evans, D. T., O'Connor, D. H., Jing, P., Dzuris, J. L., Sidney, J., Da Silva, J., . . . Watkins, D. I. (1999). Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nature Medicine, 5(11), 1270-1276.
    DOI Scopus354 WoS338 Europe PMC259
    1999 Gardezi, T., & Da Silva, J. (1999). Diversity in relation to body size in mammals: A comparative study. American Naturalist, 153(1), 110-123.
    DOI Scopus85 WoS84 Europe PMC21
    1999 Da Silva, J., & Hughes, A. L. (1999). Molecular phylogenetic evidence of cytotoxic T lymphocyte (CTL) selection on human immunodeficiency virus type 1 (HIV-1) [4]. Molecular Biology and Evolution, 16(10), 1420-1422.
    DOI Scopus8 WoS8 Europe PMC5
    1998 Da Silva, J., & Hughes, A. L. (1998). Conservation of cytotoxic T lymphocyte (CTL) epitopes as a host strategy to constrain parasite adaptation: Evidence from the nef gene of human immunodeficiency virus 1 (HIV-1). Molecular Biology and Evolution, 15(10), 1259-1268.
    DOI Scopus20 WoS22 Europe PMC17
    1996 Da Silva, J., & Bell, G. (1996). The ecology and genetics of fitness in Chlamydomonas. VII. The effect of sex on the variance in fitness and mean fitness. Evolution, 50(4), 1705-1713.
    DOI Scopus12 Europe PMC2
    1996 DaSilva, J., & Bell, G. (1996). The ecology and genetics of fitness in Chlamydomonas .7. The effect of sex on the variance in fitness and mean fitness. EVOLUTION, 50(4), 1705-1713.
    DOI WoS13 Europe PMC3
    1995 Woodroffe, R., Macdonald, D. W., & da Silva, J. (1995). Dispersal and philopatry in the European badger, Meles meles. Journal of Zoology, 237(2), 227-239.
    DOI Scopus118 WoS102
    1994 ZEYL, C., BELL, G., & DASILVA, J. (1994). TRANSPOSON ABUNDANCE IN SEXUAL AND ASEXUAL POPULATIONS OF CHLAMYDOMONAS-REINHARDTII. EVOLUTION, 48(4), 1406-1409.
    DOI WoS11 Europe PMC3
    1994 DASILVA, J., MACDONALD, D. W., & EVANS, P. G. H. (1994). NET COSTS OF GROUP LIVING IN A SOLITARY FORAGER, THE EURASIAN BADGER (MELES-MELES). BEHAVIORAL ECOLOGY, 5(2), 151-158.
    DOI WoS69
    1994 Zeyl, C., Bell, G., & da Silva, J. (1994). Transposon abundance in sexual and asexual populations of Chlamydomonas reinhardtii. Evolution, 48(4), 1406-1409.
    DOI Scopus11 Europe PMC3
    1993 da Silva, J., Woodroffe, R., & Macdonald, D. W. (1993). Habitat, food availability and group territoriality in the European badger, Meles meles. Oecologia, 95(4), 558-564.
    DOI Scopus103 WoS100 Europe PMC17
    1992 da Silva, J., Bell, G., & Burt, A. (1992). Sources of variance in protein heterozygosity: the importance of the species-protein interaction.. Heredity, 68(3), 241-252.
    DOI Scopus3 WoS7 Europe PMC3
    1992 Da Silva, J., & Bell, G. (1992). The ecology and genetics of fitness in Chlamydomonas VI. Antagonism between natural selection and sexual selection. Proceedings of the Royal Society B: Biological Sciences, 249(1326), 227-233.
    DOI Scopus16 WoS17
    1991 Da Silva, J., Winquist, S. T., Weary, D. M., Inman, A. J., Mountjoy, D. J., Krebs, E. A., & Basolo, A. L. (1991). Male swords and female preferences. Science, 253(5026), 1426-1427.
    DOI Scopus30 WoS7 Europe PMC3
    1988 da Silva, J., & Terhune, J. M. (1988). Harbour seal grouping as an anti-predator strategy. Animal Behaviour, 36(5), 1309-1316.
    DOI Scopus48 WoS45
    1986 DASILVA, J., CAMERON, J. L., & FANKBONER, P. V. (1986). MOVEMENT AND ORIENTATION PATTERNS IN THE COMMERCIAL SEA-CUCUMBER PARASTICHOPUS-CALIFORNICUS (STIMPSON) (HOLOTHUROIDEA, ASPIDOCHRITIDA). MARINE BEHAVIOUR AND PHYSIOLOGY, 12(2), 133-147.
    DOI WoS35
    1985 DASILVA, J., & NEILSON, J. D. (1985). LIMITATIONS OF USING OTOLITHS RECOVERED IN SCATS TO ESTIMATE PREY CONSUMPTION IN SEALS. CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 42(8), 1439-1446.
    DOI WoS109
  • Book Chapters

    Year Citation
    2008 Da Silva, J. (2008). Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies. In D. Flower (Ed.), Immunionformatics (Vol. 9780387729688, pp. 161-178). USA: Springer.
    DOI Scopus1 WoS1
    2006 Da Silva, J. (2006). Parallel Monte Carlo Simulation of HIV Molecular Evolution in Response to Immune Surveillance. In A. Zomaya (Ed.), Parallel computing or bioinformatics and computational biology (pp. 29-57). Hoboken, New Jersey: Wiley.
    DOI
    2001 Hughes, A., Da Silva, J., & Verra, F. (2001). Evolutionary analysis of molecular sequence data. In Molecular Epidemiology: A Practical Approach (pp. 209-231). Great Britain: Oxford University Press.
  • Conference Papers

    Year Citation
    2002 Da Silva, J., & Hughes, A. (2002). Monte Carlo simulation of HIV-1 evolution in response to selection by antibodies. In Proceedings 16th International Parallel and Distributed Processing Symposium (pp. 186-196). IEEE.
    DOI Scopus1
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  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2009 - 2013 Co-Supervisor Chloroplast DNAs Diversify Nuclear and Mitochondrial Genomes in Plants Doctor of Philosophy Doctorate Full Time Mr Dong Wang
    2008 - 2013 Co-Supervisor Comprehensive Identification and Annotation of Non-Protein-Coding Transcriptomes from Vertebrates Indicates Most ncRNAs are Regulatory Doctor of Philosophy Doctorate Full Time Dr Zhipeng Qu
  • Position: Senior Lecturer
  • Phone: 83137009
  • Email: jack.dasilva@adelaide.edu.au
  • Fax: 8313 4362
  • Campus: North Terrace
  • Building: Molecular Life Sciences, floor 2
  • Room: 2 36
  • Org Unit: Molecular and Biomedical Science

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