Research Fellow - DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Iza Denis is a National Breast Cancer Foundation of Australia Fellow at the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide. In 2009 Dr Denis completed a Bachelor in Life and Earth Sciences at the University of Rennes, France. In 2009, she undertook a Master’s program in Regenerative Medicine (funded by an ERASMUS scholarship) at the DNA damage response laboratory, National University of Galway Ireland (NUIG). Her research project was focused on elucidating cytoplasmic and nuclear signalling in response to chemotherapeutic drugs in human breast cancer cells. Dr Denis subsequently (2010) undertook an additional MSc program in Cellular Biology and Physiopathology at the University Victor Segalen of Bordeaux, France, during which she studied the role of the CXCL4 chemokine and a CXCL4 variant, CXCL4L1, in cancer-related angiogenesis. In 2014 she was awarded her PhD at the University of Nantes Cancer Research Institute, France. The focus of her PhD studies was developing new therapeutic approaches to treat mesothelioma and lung cancer, utilising nanomedicine, new epigenetic drugs and immunogenic strategies. Dr Denis has published 8 original research papers (4 as first author).
Awards and Achievements
Date Type Title Institution Name Country Amount 2017 Fellowship Post doctoral fellowship University of Adelaide Australia 400.000
Language Competency Breton Can read, write, speak, understand spoken and peer review English Can read, write, speak, understand spoken and peer review French Can read, write, speak, understand spoken and peer review Spanish; Castilian Can read, write, speak and understand spoken
Year Citation 2019 Tarulli, G., Laven-Law, G., Shehata, M., Walters, K., Denis, I., Rahman, M., . . . Hickey, T. (2019). Androgen receptor signalling promotes a luminal phenotype in mammary epithelial cells. Journal of Mammary Gland Biology and Neoplasia, 24(1), 99-108.
2017 Paltoglou, S., Das, R., Townley, S., Hickey, T., Tarulli, G., Coutinho, I., . . . Selth, L. (2017). Novel androgen receptor coregulator GRHL2 exerts both oncogenic and antimetastatic functions in prostate cancer. Cancer Research, 77(13), 3417-3430.
DOI Scopus14 WoS12 Europe PMC10
2017 Das, R., Gregory, P., Fernandes, R., Denis, I., Wang, Q., Townley, S., . . . Selth, L. (2017). MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Research, 77(4), 1021-1034.
DOI Scopus29 WoS29 Europe PMC18
2016 Bahhaj, F. E., Denis, I., Pichavant, L., Delatouche, R., Collette, F., Linot, C., . . . Bertrand, P. (2016). Histone deacetylase inhibitors delivery using nanoparticles with intrinsic passive tumor targeting properties for tumor therapy. Theranostics, 6(6), 795-807.
2015 Denis, I., el Bahhaj, F., Collette, F., Delatouche, R., Gueugnon, F., Pouliquen, D., . . . Blanquart, C. (2015). Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 95, 369-376.
2014 Denis, I., el Bahhaj, F., Collette, F., Delatouche, R., Gueugnon, F., Pouliquen, D., . . . Blanquart, C. (2014). Vorinostat-Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting. BIOMACROMOLECULES, 15(12), 4534-4543.
2014 Denis, I., Cellerin, L., Gregoire, M., & Blanquart, C. (2014). Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma. Oncotarget, 5(22).
2014 Zwick, V., Chatzivasileiou, A. -O., Deschamps, N., Roussaki, M., Simões-Pires, C. A., Nurisso, A., . . . Cuendet, M. (2014). Aurones as histone deacetylase inhibitors: identification of key features. Bioorganic & Medicinal Chemistry Letters, 24(23), 5497-5501.
2013 Gueugnon, F., Denis, I., Pouliquen, D., Collette, F., Delatouche, R., Héroguez, V., . . . Blanquart, C. (2013). Nanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targeting. Biomacromolecules, 14(7), 2396-2402.
2013 Delatouche, R., Denis, I., Grinda, M., El Bahhaj, F., Baucher, E., Collette, F., . . . Bertrand, P. (2013). Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 85(3), 862-872.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 Co-Supervisor Role of the GATA3 transcription factor on AR signalling In ER-positive breast cancer Doctor of Philosophy Doctorate Full Time Mrs Leila HosseinZadeh
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