
Dr Imre Kouw
Ext-Funded Research Fellow (B)
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Imre Kouw, BSc Dietetics and MSc Nutrition, is Postdoctoral Research Fellow at the RAH ICU Research Group. Imre completed her PhD in 2018 at Maastricht University under supervision of Professor Luc van Loon, which focussed on nutritional strategies to attenuate muscle loss during hospitalization in older and clinical populations. During her PhD, she gained extensive experience in stable isotope tracer methodology to assess muscle protein metabolism. She conducted multiple nutritional intervention trials in healthy older volunteers and clinical populations (patients with frailty, Type 2 Diabetes, elective hip or knee replacement, or hip fracture surgery and those prior to bariatric surgery). Imre has been awarded multiple research awards during her PhD including the European Society for Clinical Nutrition and Metabolism Best Oral Presentation (2016) and Gatorade Sport Science Institute (2016) Nutrition Award, and more recently a price for Best PhD Thesis 2019 in Clinical Nutrition and Metabolism (Dutch Nutrition Society for Clinical Nutrition and Metabolism) and the British Nutrition Foundation Drummond Early Career Scientist Award (2020). Imre received an ESPEN Research Fellowship (2019) to investigate the effect of intermittent fasting on muscle protein metabolism in overweight and obese middle-aged men at the Exercise and Nutrition Research Program at Australian Catholic University in Melbourne and apply a novel tracer methodology, deuterated water. Imre recently joined the RAH ICU Research Group in July 2020 where she will continue her postdoctoral training on muscle protein metabolism in Intensive Care Unit patients, she recently received a prestigious Rubicon Fellowship (2020-2022) from the Netherlands Organisation for Health Research and Development NOW/ZonMW. Imre has previous (co-)supervisory experience with BSc, MSc, and PhD students.
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Awards and Achievements
Date Type Title Institution Name Country Amount 2020 Award Drummond Early Career Award British Nutrition Foundation United Kingdom - 2019 Award PhD Thesis Price NESPEN Netherlands - 2016 Research Award ESPEN Travel Grant European Society of Clinical Nutrition and Metabolism United Kingdom - 2016 Award GSSI Sports Nutrition Award Gatorade Sports Science Institute United Kingdom - -
Research Interests
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Journals
Year Citation 2023 Pinckaers, P. J. M., Kouw, I. W. K., Gorissen, S. H. M., Houben, L. H. P., Senden, J. M., Wodzig, W. K. H. W., . . . van Loon, L. J. C. (2023). The Muscle Protein Synthetic Response to the Ingestion of a Plant-Derived Protein Blend Does Not Differ from an Equivalent Amount of Milk Protein in Healthy Young Males. The Journal of nutrition, 152(12), 2734-2743.
Scopus1 WoS22022 Parr, E. B., Kouw, I. W. K., Wheeler, M. J., Radford, B. E., Hall, R. C., Senden, J. M., . . . Hawley, J. A. (2022). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial. Obesity, 31 Suppl 1(S1), 11 pages.
2022 Bland, K. A., Kouw, I. W. K., van Loon, L. J. C., Zopf, E. M., & Fairman, C. M. (2022). Exercise-Based Interventions to Counteract Skeletal Muscle Mass Loss in People with Cancer: Can We Overcome the Odds?. Sports Medicine, 52(5), 1009-1027.
Scopus3 WoS4 Europe PMC32022 Weijzen, M. E. G., Van Gassel, R. J. J., Kouw, I. W. K., Trommelen, J., Gorissen, S. H. M., Van Kranenburg, J., . . . Van Loon, L. J. C. (2022). Ingestion of Free Amino Acids Compared with an Equivalent Amount of Intact Protein Results in More Rapid Amino Acid Absorption and Greater Postprandial Plasma Amino Acid Availability Without Affecting Muscle Protein Synthesis Rates in Young Adults in a Double-Blind Randomized Trial. Journal of Nutrition, 152(1), 59-67.
Scopus9 WoS10 Europe PMC22022 Chapple, L. -A. S., Kouw, I. W. K., Summers, M. J., Weinel, L. M., Gluck, S., Raith, E., . . . Chapman, M. J. (2022). Muscle Protein Synthesis Following Protein Administration in Critical Illness. American Journal of Respiratory and Critical Care Medicine, 206(6), 740-749.
Scopus4 WoS4 Europe PMC42022 Kouw, I. W. K., Heilbronn, L. K., & van Zanten, A. R. H. (2022). Intermittent feeding and circadian rhythm in critical illness. Current Opinion in Critical Care, 28(4), 381-388.
2021 Pinckaers, P. J. M., Kouw, I. W. K., Hendriks, F. K., Van Kranenburg, J. M. X., De Groot, L. C. P. G. M., Verdijk, L. B., . . . Van Loon, L. J. C. (2021). No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. British Journal of Nutrition, 126(12), 1832-1842.
Scopus17 WoS19 Europe PMC122021 Chapple, L. A. S., Dirks, M. L., & Kouw, I. W. K. (2021). Stable isotope approaches to study muscle mass outcomes in clinical populations. Clinical Nutrition Open Science, 36, 98-108.
Scopus12021 Holwerda, A. M., Trommelen, J., Kouw, I. W. K., Senden, J. M., Goessens, J. P. B., Van Kranenburg, J., . . . Van Loon, L. J. C. (2021). Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men. International Journal of Sport Nutrition and Exercise Metabolism, 31(3), 217-226.
Scopus2 WoS3 Europe PMC22021 Kouw, I. W. K., Pinckaers, P. J. M., Le Bourgot, C., Van Kranenburg, J. M. X., Zorenc, A. H., De Groot, L. C. P. G. M., . . . Van Loon, L. J. C. (2021). Ingestion of an ample amount of meat substitute based upon a lysine-enriched, plant-based protein blend stimulates postprandial muscle protein synthesis to a similar extent as an isonitrogenous amount of chicken in healthy, young men. British Journal of Nutrition, 128(10), 11 pages.
Scopus5 WoS3 Europe PMC12020 Fuchs, C. J., Kouw, I. W. K., Churchward-Venne, T. A., Smeets, J. S. J., Senden, J. M., van Marken Lichtenbelt, W. D., . . . van Loon, L. J. C. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. Journal of Physiology, 598(4), 755-772.
Scopus30 WoS26 Europe PMC162020 Weijzen, M. E. G., Kouw, I. W. K., Geerlings, P., Verdijk, L. B., & van Loon, L. J. C. (2020). During Hospitalization, Older Patients at Risk for Malnutrition Consume <0.65 Grams of Protein per Kilogram Body Weight per Day.. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 35(4), 655-663.
Scopus7 WoS5 Europe PMC42020 Gonzalez, J., Dirks, M. L., Holwerda, A. M., Kouw, I. W., & van Loon, L. J. C. (2020). Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.. European Journal of Applied Physiology, 120(9), 2083-2094.
Scopus4 WoS42020 Gorissen, S. H. M., Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Pennings, B., Groen, B. B. L., . . . van Loon, L. J. C. (2020). Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. The Journal of nutrition, 150(8), 2041-2050.
Scopus38 WoS36 Europe PMC222019 Kouw, I. W. K., Van Dijk, J. W., Horstman, A. M. H., Kramer, I. F., Goessens, J. P. B., Van Dielen, F. M. H., . . . Van Loon, L. J. C. (2019). Basal and postprandial myofibrillar protein synthesis rates do not differ between lean and obese middle-Aged men. Journal of Nutrition, 149(9), 1533-1542.
Scopus13 WoS14 Europe PMC82019 Snijders, T., Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Verdijk, L. B., & van Loon, L. J. C. (2019). The impact of pre-sleep protein ingestion on the skeletal muscle adaptive response to exercise in humans: An update. Frontiers in Nutrition, 6, 8 pages.
Scopus32 WoS34 Europe PMC242019 Dirks, M. L., Smeets, J. S. J., Holwerda, A. M., Kouw, I. W. K., Marzuca-Nassr, G. N., Gijsen, A. P., . . . van Loon, L. J. C. (2019). Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. American Journal of Physiology - Endocrinology and Metabolism, 316(3), E536-E545.
Scopus17 WoS17 Europe PMC72019 Horstman, A. M. H., Kouw, I. W. K., Van Dijk, J. W., Hamer, H. M., Groen, B. B. L., Van Kranenburg, J., . . . Van Loon, L. J. C. (2019). The muscle protein synthetic response to whey protein ingestion is greater in middle-aged women compared with men. Journal of Clinical Endocrinology and Metabolism, 104(4), 994-1004.
Scopus7 WoS7 Europe PMC42019 Weijzen, M. E. G., Kouw, I. W. K., Verschuren, A. A. J., Muyters, R., Geurts, J. A., Emans, P. J., . . . van Loon, L. J. C. (2019). Protein Intake Falls below 0.6 g·kg <sup>-1</sup> ·d <sup>-1</sup> in Healthy, Older Patients Admitted for Elective Hip or Knee Arthroplasty. Journal of Nutrition, Health and Aging, 23(3), 299-305.
Scopus8 WoS7 Europe PMC32019 Kouw, I. W. K., Groen, B. B. L., Smeets, J. S. J., Kramer, I. F., van Kranenburg, J. M. X., Nilwik, R., . . . Verdijk, L. B. (2019). One Week of Hospitalization Following Elective Hip Surgery Induces Substantial Muscle Atrophy in Older Patients. Journal of the American Medical Directors Association, 20(1), 35-42.
Scopus35 WoS34 Europe PMC222019 Fuchs, C. J., Kouw, I. W. K., Churchward-Venne, T. A., Smeets, J. S. J., Senden, J. M., Lichtenbelt, W. D. V. M., . . . van Loon, L. J. C. (2019). Post-exercise Cooling Impairs Muscle Protein Synthesis Rates In Healthy Young Males. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 51(6), 543.
2018 Trommelen, J., Kouw, I., Holwerda, A., Snijders, T., Halson, S., Rollo, I., . . . van Loon, L. (2018). Presleep dietary protein-derived amino acids are incorporated in myofibrillar protein during postexercise overnight recovery. American journal of physiology. Endocrinology and metabolism, 314(5), E457-E467.
Scopus51 WoS45 Europe PMC302017 Nyakayiru, J., Kouw, I. W., Cermak, N. M., Senden, J. M., van Loon, L. J., & Verdijk, L. B. (2017). Erratum: Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. J Appl Physiol 123: 637– 644, 2017. First published June 29, 2017; doi:10.1152/japplphysiol.01036.2016. Journal of Applied Physiology, 123(6), 1738.
2017 Gorissen, S., Horstman, A., Franssen, R., Kouw, I., Wall, B., Burd, N., . . . Van Loon, L. (2017). Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: A randomized trial. American Journal of Clinical Nutrition, 105(2), 332-342.
Scopus35 WoS35 Europe PMC222017 Kramer, I., Verdijk, L., Hamer, H., Verlaan, S., Luiking, Y., Kouw, I., . . . van Loon, L. (2017). Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clinical Nutrition, 36(5), 1440-1449.
Scopus29 WoS27 Europe PMC192017 Nyakayiru, J., Kouw, I., Cermak, N., Senden, J., Van Loon, L., & Verdijk, L. (2017). Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology, 123(3), 637-644.
Scopus34 WoS35 Europe PMC212017 Kouw, I., Holwerda, A., Trommelen, J., Kramer, I., Bastiaanse, J., Halson, S., . . . van Loon, L. (2017). Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. Journal of Nutrition, 147(12), 2252-2261.
Scopus64 WoS61 Europe PMC392016 Klinkenberg, L. J. J., Wildi, K., Van Der Linden, N., Kouw, I. W. K., Niens, M., Twerenbold, R., . . . Meex, S. J. R. (2016). Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry, 62(12), 1602-1611.
Scopus61 WoS59 Europe PMC222016 Trommelen, J., Holwerda, A., Kouw, I., Langer, H., Halson, S., Rollo, I., . . . Van Loon, L. (2016). Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates. Medicine and Science in Sports and Exercise, 48(12), 2517-2525.
Scopus48 WoS44 Europe PMC312016 Kouw, I., Cermak, N., Burd, N., Churchward-Venne, T., Senden, J., Gijsen, A., & van Loon, L. (2016). Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients. American Journal of Physiology - Endocrinology and Metabolism, 311(2), E325-E334.
Scopus7 WoS6 Europe PMC62016 Holwerda, A., Kouw, I., Trommelen, J., Halson, S., Wodzig, W., Verdijk, L., & van Loon, L. (2016). Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men. Journal of Nutrition, 146(7), 1307-1314.
Scopus44 WoS43 Europe PMC272016 Trommelen, J., Holwerda, A. M., Kouw, I. W. K., Halson, S. L., Verdijk, L. B., & van Loon, L. J. C. (2016). Protein Ingestion Before Sleep Provides Precursors For Post-exercise Overnight De Novo Muscle Protein Synthesis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5), 4.
2016 Holwerda, A. M., Kouw, I. W. K., Trommelen, J., Halson, S. L., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2016). Exercise Enhances The Overnight Muscle Protein Synthetic Response To Pre-sleep Protein Feeding In Older Males. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5), 3.
2015 Kramer, I. F., Verdijk, L. B., Hamer, H. M., Verlaan, S., Luiking, Y., Kouw, I. W. K., . . . Van Loon, L. J. C. (2015). Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial. Journal of Clinical Endocrinology and Metabolism, 100(11), 4124-4132.
Scopus26 WoS23 Europe PMC152015 Kouw, I. W. K., Gorissen, S. H. M., Burd, N. A., Cermak, N. M., Gijsen, A. P., Van Kranenburg, J., & Van Loon, L. J. C. (2015). Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls. Journal of Clinical Endocrinology and Metabolism, 100(8), 3103-3111.
Scopus15 WoS15 Europe PMC142015 Cermak, N. M., Hansen, D., Kouw, I. W. K., van Dijk, J. W., Blackwell, J. R., Jones, A. M., . . . van Loon, L. J. C. (2015). A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus. Nutrition Research, 35(8), 674-680.
Scopus20 WoS19 Europe PMC132014 Burd, N. A., Cermak, N. M., Kouw, I. W. K., Gorissen, S. H., Gijsen, A. P., & Van Loon, L. J. C. (2014). The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology, 117(11), 1363-1370.
Scopus35 WoS35 Europe PMC232011 Kouw, I. W., Tieland, M., & Gorissen, S. H. (2011). A step towards underpinning the molecular signalling events regulating muscle protein loss in critically ill patients. Journal of Physiology, 589(24), 5925-5926.
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Committee Memberships
Date Role Committee Institution Country 2019 - ongoing Secretary AuSPEN Scientific Committee Australasian Society for Parenteral and Enteral Nutrition Australia -
Memberships
Date Role Membership Country 2013 - ongoing Member European Society of Clinical Nutrition and Metabolism Switzerland
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