Imre Kouw

Imre Kouw

Adelaide Medical School

Faculty of Health and Medical Sciences

Dr Imre Kouw, BSc Dietetics and MSc Nutrition, is Postdoctoral Research Fellow at the RAH ICU Research Group. Imre completed her PhD in 2018 at Maastricht University under supervision of Professor Luc van Loon, which focussed on nutritional strategies to attenuate muscle loss during hospitalization in older and clinical populations. During her PhD, she gained extensive experience in stable isotope tracer methodology to assess muscle protein metabolism. She conducted multiple nutritional intervention trials in healthy older volunteers and clinical populations (patients with frailty, Type 2 Diabetes, elective hip or knee replacement, or hip fracture surgery and those prior to bariatric surgery). Imre has been awarded multiple research awards during her PhD including the European Society for Clinical Nutrition and Metabolism Best Oral Presentation (2016) and Gatorade Sport Science Institute (2016) Nutrition Award, and more recently a price for Best PhD Thesis 2019 in Clinical Nutrition and Metabolism (Dutch Nutrition Society for Clinical Nutrition and Metabolism) and the British Nutrition Foundation Drummond Early Career Scientist Award (2020). Imre received an ESPEN Research Fellowship (2019) to investigate the effect of intermittent fasting on muscle protein metabolism in overweight and obese middle-aged men at the Exercise and Nutrition Research Program at Australian Catholic University in Melbourne and apply a novel tracer methodology, deuterated water. Imre recently joined the RAH ICU Research Group in July 2020 where she will continue her postdoctoral training on muscle protein metabolism in Intensive Care Unit patients, she recently received a prestigious Rubicon Fellowship (2020-2022) from the Netherlands Organisation for Health Research and Development NOW/ZonMW. Imre has previous (co-)supervisory experience with BSc, MSc, and PhD students.

  • Journals
    Year Citation
    2024 Pinckaers, P. J. M., Smeets, J. S. J., Kouw, I. W. K., Goessens, J. P. B., Gijsen, A. P. B., de Groot, L. C. P. G. M., . . . Snijders, T. (2024). Post-prandial muscle protein synthesis rates following the ingestion of pea-derived protein do not differ from ingesting an equivalent amount of milk-derived protein in healthy, young males. European Journal of Nutrition, 63(3), 893-904.
    DOI
    2024 van Gassel, R. J., Weijzen, M. E., Kouw, I. W., Senden, J. M., Wodzig, W. K., Olde Damink, S. W., . . . van Loon, L. J. (2024). Administration of Free Amino Acids Improves Exogenous Amino Acid Availability when Compared with Intact Protein in Critically Ill Patients: A Randomized Controlled Study. Journal of Nutrition, 154(2), 554-564.
    DOI
    2024 Pinckaers, P. J. M., Weijzen, M. E. G., Houben, L. H. P., Zorenc, A. H., Kouw, I. W. K., de Groot, L. C. P. G. M., . . . van Loon, L. J. C. (2024). The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults. Amino Acids, 56(1), 14 pages.
    DOI
    2024 Viner Smith, E., Kouw, I. W. K., Summers, M. J., Louis, R., Trahair, L., O'Connor, S. N., . . . Chapple, L. A. S. (2024). Comparison of energy intake in critical illness survivors, general medical patients and healthy volunteers: A descriptive cohort study. Journal of Parenteral and Enteral Nutrition, 48(3), 275-283.
    DOI
    2023 Parr, E. B., Kouw, I. W. K., Wheeler, M. J., Radford, B. E., Hall, R. C., Senden, J. M., . . . Hawley, J. A. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial. Obesity, 31(S1), 116-126.
    DOI Scopus3 WoS1 Europe PMC2
    2023 Hermans, A. J. H., Laarhuis, B. I., Kouw, I. W. K., & Van Zanten, A. R. H. (2023). Current insights in ICU nutrition: tailored nutrition. Current Opinion in Critical Care, 29(2), 101-107.
    DOI Scopus4 WoS3 Europe PMC1
    2023 Melchers, M., Hubertine Hermans, A. J., Hulsen, S. B., Kehinde Kouw, I. W., & Hubert van Zanten, A. R. (2023). Individualised energy and protein targets achieved during intensive care admission are associated with lower mortality in mechanically ventilated COVID-19 patients: The COFEED-19 study. Clinical Nutrition, 42(12), 2486-2492.
    DOI Scopus1
    2022 Bland, K. A., Kouw, I. W. K., van Loon, L. J. C., Zopf, E. M., & Fairman, C. M. (2022). Exercise-Based Interventions to Counteract Skeletal Muscle Mass Loss in People with Cancer: Can We Overcome the Odds?. Sports Medicine, 52(5), 1009-1027.
    DOI Scopus5 WoS5 Europe PMC3
    2022 Weijzen, M. E. G., Van Gassel, R. J. J., Kouw, I. W. K., Trommelen, J., Gorissen, S. H. M., Van Kranenburg, J., . . . Van Loon, L. J. C. (2022). Ingestion of Free Amino Acids Compared with an Equivalent Amount of Intact Protein Results in More Rapid Amino Acid Absorption and Greater Postprandial Plasma Amino Acid Availability Without Affecting Muscle Protein Synthesis Rates in Young Adults in a Double-Blind Randomized Trial. Journal of Nutrition, 152(1), 59-67.
    DOI Scopus32 WoS18 Europe PMC12
    2022 Chapple, L. -A. S., Kouw, I. W. K., Summers, M. J., Weinel, L. M., Gluck, S., Raith, E., . . . Chapman, M. J. (2022). Muscle Protein Synthesis Following Protein Administration in Critical Illness. American Journal of Respiratory and Critical Care Medicine, 206(6), 740-749.
    DOI Scopus37 WoS19 Europe PMC22
    2022 Kouw, I. W. K., Heilbronn, L. K., & van Zanten, A. R. H. (2022). Intermittent feeding and circadian rhythm in critical illness. Current Opinion in Critical Care, 28(4), 381-388.
    DOI Scopus6 WoS3 Europe PMC4
    2022 Pinckaers, P. J., Kouw, I. W., Gorissen, S. H., Houben, L. H., Senden, J. M., Wodzig, W. K., . . . van Loon, L. J. (2022). The Muscle Protein Synthetic Response to the Ingestion of a Plant-Derived Protein Blend Does Not Differ from an Equivalent Amount of Milk Protein in Healthy Young Males. Journal of Nutrition, 152(12), 2734-2743.
    DOI Scopus13 WoS5 Europe PMC10
    2021 Pinckaers, P. J. M., Kouw, I. W. K., Hendriks, F. K., Van Kranenburg, J. M. X., De Groot, L. C. P. G. M., Verdijk, L. B., . . . Van Loon, L. J. C. (2021). No differences in muscle protein synthesis rates following ingestion of wheat protein, milk protein, and their protein blend in healthy, young males. British Journal of Nutrition, 126(12), 1832-1842.
    DOI Scopus33 WoS24 Europe PMC24
    2021 Chapple, L. A. S., Dirks, M. L., & Kouw, I. W. K. (2021). Stable isotope approaches to study muscle mass outcomes in clinical populations. Clinical Nutrition Open Science, 36, 98-108.
    DOI Scopus2
    2021 Holwerda, A. M., Trommelen, J., Kouw, I. W. K., Senden, J. M., Goessens, J. P. B., Van Kranenburg, J., . . . Van Loon, L. J. C. (2021). Exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in healthy older men. International Journal of Sport Nutrition and Exercise Metabolism, 31(3), 217-226.
    DOI Scopus8 WoS5 Europe PMC6
    2021 Kouw, I. W. K., Pinckaers, P. J. M., Le Bourgot, C., Van Kranenburg, J. M. X., Zorenc, A. H., De Groot, L. C. P. G. M., . . . Van Loon, L. J. C. (2021). Ingestion of an ample amount of meat substitute based upon a lysine-enriched, plant-based protein blend stimulates postprandial muscle protein synthesis to a similar extent as an isonitrogenous amount of chicken in healthy, young men. British Journal of Nutrition, 128(10), 11 pages.
    DOI Scopus16 WoS10 Europe PMC8
    2020 Fuchs, C. J., Kouw, I. W. K., Churchward-Venne, T. A., Smeets, J. S. J., Senden, J. M., van Marken Lichtenbelt, W. D., . . . van Loon, L. J. C. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. Journal of Physiology, 598(4), 755-772.
    DOI Scopus36 WoS29 Europe PMC20
    2020 Weijzen, M. E. G., Kouw, I. W. K., Geerlings, P., Verdijk, L. B., & van Loon, L. J. C. (2020). During Hospitalization, Older Patients at Risk for Malnutrition Consume <0.65 Grams of Protein per Kilogram Body Weight per Day.. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 35(4), 655-663.
    DOI Scopus17 WoS6 Europe PMC6
    2020 Gonzalez, J., Dirks, M. L., Holwerda, A. M., Kouw, I. W., & van Loon, L. J. C. (2020). Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.. European Journal of Applied Physiology, 120(9), 2083-2094.
    DOI Scopus8 WoS4 Europe PMC3
    2020 Gorissen, S. H. M., Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Pennings, B., Groen, B. B. L., . . . van Loon, L. J. C. (2020). Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. The Journal of nutrition, 150(8), 2041-2050.
    DOI Scopus67 WoS48 Europe PMC34
    2019 Kouw, I. W. K., Van Dijk, J. W., Horstman, A. M. H., Kramer, I. F., Goessens, J. P. B., Van Dielen, F. M. H., . . . Van Loon, L. J. C. (2019). Basal and postprandial myofibrillar protein synthesis rates do not differ between lean and obese middle-Aged men. Journal of Nutrition, 149(9), 1533-1542.
    DOI Scopus16 WoS14 Europe PMC9
    2019 Snijders, T., Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Verdijk, L. B., & van Loon, L. J. C. (2019). The impact of pre-sleep protein ingestion on the skeletal muscle adaptive response to exercise in humans: An update. Frontiers in Nutrition, 6, 8 pages.
    DOI Scopus41 WoS40 Europe PMC28
    2019 Dirks, M. L., Smeets, J. S. J., Holwerda, A. M., Kouw, I. W. K., Marzuca-Nassr, G. N., Gijsen, A. P., . . . van Loon, L. J. C. (2019). Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. American Journal of Physiology - Endocrinology and Metabolism, 316(3), E536-E545.
    DOI Scopus24 WoS20 Europe PMC7
    2019 Horstman, A. M. H., Kouw, I. W. K., Van Dijk, J. W., Hamer, H. M., Groen, B. B. L., Van Kranenburg, J., . . . Van Loon, L. J. C. (2019). The muscle protein synthetic response to whey protein ingestion is greater in middle-aged women compared with men. Journal of Clinical Endocrinology and Metabolism, 104(4), 994-1004.
    DOI Scopus10 WoS10 Europe PMC6
    2019 Weijzen, M. E. G., Kouw, I. W. K., Verschuren, A. A. J., Muyters, R., Geurts, J. A., Emans, P. J., . . . van Loon, L. J. C. (2019). Protein Intake Falls below 0.6 g·kg <sup>-1</sup> ·d <sup>-1</sup> in Healthy, Older Patients Admitted for Elective Hip or Knee Arthroplasty. Journal of Nutrition, Health and Aging, 23(3), 299-305.
    DOI Scopus12 WoS7 Europe PMC3
    2019 Kouw, I. W. K., Groen, B. B. L., Smeets, J. S. J., Kramer, I. F., van Kranenburg, J. M. X., Nilwik, R., . . . Verdijk, L. B. (2019). One Week of Hospitalization Following Elective Hip Surgery Induces Substantial Muscle Atrophy in Older Patients. Journal of the American Medical Directors Association, 20(1), 35-42.
    DOI Scopus40 WoS38 Europe PMC27
    2019 Fuchs, C. J., Kouw, I. W. K., Churchward-Venne, T. A., Smeets, J. S. J., Senden, J. M., Lichtenbelt, W. D. V. M., . . . van Loon, L. J. C. (2019). Post-exercise Cooling Impairs Muscle Protein Synthesis Rates In Healthy Young Males. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 51(6), 543.
    DOI
    2018 Trommelen, J., Kouw, I. W. K., Holwerda, A. M., Snijders, T., Halson, S. L., Rollo, I., . . . van Loon, L. J. C. (2018). Presleep dietary protein-derived amino acids are incorporated in myofibrillar protein during postexercise overnight recovery. American journal of physiology. Endocrinology and metabolism, 314(5), E457-E467.
    DOI Scopus57 WoS49 Europe PMC35
    2017 Nyakayiru, J., Kouw, I. W., Cermak, N. M., Senden, J. M., van Loon, L. J., & Verdijk, L. B. (2017). Erratum: Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. J Appl Physiol 123: 637– 644, 2017. First published June 29, 2017; doi:10.1152/japplphysiol.01036.2016. Journal of Applied Physiology, 123(6), 1738.
    DOI
    2017 Gorissen, S. H. M., Horstman, A. M. H., Franssen, R., Kouw, I. W. K., Wall, B. T., Burd, N. A., . . . Van Loon, L. J. C. (2017). Habituation to low or high protein intake does not modulate basal or postprandial muscle protein synthesis rates: A randomized trial. American Journal of Clinical Nutrition, 105(2), 332-342.
    DOI Scopus40 WoS38 Europe PMC26
    2017 Kramer, I. F., Verdijk, L. B., Hamer, H. M., Verlaan, S., Luiking, Y. C., Kouw, I. W. K., . . . van Loon, L. J. C. (2017). Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clinical Nutrition, 36(5), 1440-1449.
    DOI Scopus32 WoS30 Europe PMC22
    2017 Nyakayiru, J., Kouw, I. W. K., Cermak, N. M., Senden, J. M., Van Loon, L. J. C., & Verdijk, L. B. (2017). Sodium nitrate ingestion increases skeletal muscle nitrate content in humans. Journal of Applied Physiology, 123(3), 637-644.
    DOI Scopus41 WoS39 Europe PMC25
    2017 Kouw, I. W. K., Holwerda, A. M., Trommelen, J., Kramer, I. F., Bastiaanse, J., Halson, S. L., . . . van Loon, L. J. C. (2017). Protein ingestion before sleep increases overnight muscle protein synthesis rates in healthy older men: A randomized controlled trial. Journal of Nutrition, 147(12), 2252-2261.
    DOI Scopus74 WoS65 Europe PMC44
    2016 Klinkenberg, L. J. J., Wildi, K., Van Der Linden, N., Kouw, I. W. K., Niens, M., Twerenbold, R., . . . Meex, S. J. R. (2016). Diurnal rhythm of cardiac troponin: Consequences for the diagnosis of acute myocardial infarction. Clinical Chemistry, 62(12), 1602-1611.
    DOI Scopus73 WoS64 Europe PMC29
    2016 Trommelen, J., Holwerda, A. M., Kouw, I. W. K., Langer, H., Halson, S. L., Rollo, I., . . . Van Loon, L. J. C. (2016). Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates. Medicine and Science in Sports and Exercise, 48(12), 2517-2525.
    DOI Scopus58 WoS47 Europe PMC36
    2016 Kouw, I. W. K., Cermak, N. M., Burd, N. A., Churchward-Venne, T. A., Senden, J. M., Gijsen, A. P., & van Loon, L. J. C. (2016). Sodium nitrate co-ingestion with protein does not augment postprandial muscle protein synthesis rates in older, type 2 diabetes patients. American Journal of Physiology - Endocrinology and Metabolism, 311(2), E325-E334.
    DOI Scopus7 WoS6 Europe PMC6
    2016 Holwerda, A. M., Kouw, I. W. K., Trommelen, J., Halson, S. L., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2016). Physical activity performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion in older men. Journal of Nutrition, 146(7), 1307-1314.
    DOI Scopus50 WoS44 Europe PMC30
    2016 Trommelen, J., Holwerda, A. M., Kouw, I. W. K., Halson, S. L., Verdijk, L. B., & van Loon, L. J. C. (2016). Protein Ingestion Before Sleep Provides Precursors For Post-exercise Overnight De Novo Muscle Protein Synthesis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5), 4.
    DOI
    2016 Holwerda, A. M., Kouw, I. W. K., Trommelen, J., Halson, S. L., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2016). Exercise Enhances The Overnight Muscle Protein Synthetic Response To Pre-sleep Protein Feeding In Older Males. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(5), 3.
    DOI
    2015 Kramer, I. F., Verdijk, L. B., Hamer, H. M., Verlaan, S., Luiking, Y., Kouw, I. W. K., . . . Van Loon, L. J. C. (2015). Impact of the macronutrient composition of a nutritional supplement on muscle protein synthesis rates in older men: A randomized, double blind, controlled trial. Journal of Clinical Endocrinology and Metabolism, 100(11), 4124-4132.
    DOI Scopus28 WoS24 Europe PMC17
    2015 Kouw, I. W. K., Gorissen, S. H. M., Burd, N. A., Cermak, N. M., Gijsen, A. P., Van Kranenburg, J., & Van Loon, L. J. C. (2015). Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls. Journal of Clinical Endocrinology and Metabolism, 100(8), 3103-3111.
    DOI Scopus16 WoS15 Europe PMC15
    2015 Cermak, N. M., Hansen, D., Kouw, I. W. K., van Dijk, J. W., Blackwell, J. R., Jones, A. M., . . . van Loon, L. J. C. (2015). A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus. Nutrition Research, 35(8), 674-680.
    DOI Scopus20 WoS20 Europe PMC14
    2014 Burd, N. A., Cermak, N. M., Kouw, I. W. K., Gorissen, S. H., Gijsen, A. P., & Van Loon, L. J. C. (2014). The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. Journal of Applied Physiology, 117(11), 1363-1370.
    DOI Scopus37 WoS36 Europe PMC24
    2011 Kouw, I. W., Tieland, M., & Gorissen, S. H. (2011). A step towards underpinning the molecular signalling events regulating muscle protein loss in critically ill patients. Journal of Physiology, 589(24), 5925-5926.
    DOI

  • Conference Papers
    Year Citation
    2023 Parr, E. B., Devlin, B. L., Radford, B. E., Hall, R. C., Flint, S. A., Steventon-Lorenzen, N., . . . Hawley, J. A. (2023). Time-restricted eating and personalised dietary advice induce similar effects on HbA<sub>1c</sub> over six months in people with type 2 diabetes. In DIABETOLOGIA Vol. 66 (pp. S362). GERMANY, Hamburg: SPRINGER.

  • Conference Items
    Year Citation
    2023 Kouw, I. W. K., Chapple, L. -A. S., Louis, R., Summers, M., Jones, K., Horowitz, M., & Chapman, M. (2023). Comparative effects of intermittent and continuous enteral feeding on glycaemic control in critically ill patients. Poster session presented at the meeting of DIABETOLOGIA. GERMANY, Hamburg: SPRINGER.
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