Ian Parkinson

Ian Parkinson

Student Experience

Division of Academic and Student Engagement

Dr Ian ParkinsonMy substantive position is as a Senior Medical Scientist in the Bone and Joint Research Laboratory in Surgical Pathology, SA Pathology, where I have been employed since 1980. This laboratory is also incorporated within the Hanson Institute. My major research areas are the aetiology of osteoporosis and osteoarthritis. I am investigating the role of cancellous bone architecture and bone mineralisation in determining the strength of vertebral bodies. This research utilises state-of-the-art micro-CT imaging, backscattered electron microscopy and mechanical testing apparatus. I am using an animal model of osteoarthritis to study the onset and progression of this disease.My role in the Discipline of Pathology is to provide supervision of bone and joint-related pathology research for undergraduate research topics, Honours projects and PhD projects.

Year Citation
2019 Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J., & Müller, R. (2019). Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans. Plos One, 14(2), 11 pages.
DOI Scopus3 WoS2 Europe PMC2
2018 Hopkins, E., Moffat, D., Smith, C., Wong, M., Parkinson, I., Nespolon, W., . . . Nguyen, P. (2018). Accuracy of rapid on-site evaluation of endobronchial ultrasound guided transbronchial needle aspirates by respiratory registrars in training and medical scientists compared to specialist pathologists-an initial pilot study. Journal of Thoracic Disease, 10(7), 3922-3927.
DOI Scopus9 WoS9 Europe PMC6
2016 Hopkins, E., Moffat, D., Parkinson, I., Robinson, P., Jersmann, H., Dougherty, B., . . . Nguyen, P. (2016). Cell block samples from endobronchial ultrasound transbronchial needle aspiration provide sufficient material for ancillary testing in lung cancer-A quaternary referral centre experience. Journal of Thoracic Disease, 8(9), 2544-2550.
DOI Scopus31 WoS29 Europe PMC24
2016 Badilatti, S. D., Christen, P., Parkinson, I., & Müller, R. (2016). Load-adaptive bone remodeling simulations reveal osteoporotic microstructural and mechanical changes in whole human vertebrae. Journal of Biomechanics, 49(16), 3770-3779.
DOI Scopus17 Europe PMC10
2016 Badilatti, S. D., Christen, P., Levchuk, A., Marangalou, J. H., van Rietbergen, B., Parkinson, I., & Müller, R. (2016). Large-scale microstructural simulation of load-adaptive bone remodeling in whole human vertebrae. Biomechanics and Modeling in Mechanobiology, 15(1), 83-95.
DOI Scopus17 Europe PMC11
2015 Perilli, E., Parkinson, I., Truong, L., Chong, K., Fazzalari, N., & Osti, O. (2015). Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling. European Spine Journal, 24(9), 1926-1934.
DOI Scopus76 WoS65 Europe PMC60
2014 Briggs, A., Perilli, E., Codrington, J., Reynolds, K., Parkinson, I., & Wark, J. (2014). Subregional DXA-derived vertebral bone mineral measures are stronger predictors of failure load in specimens with lower areal bone mineral density, compared to those with higher areal bone mineral density. Calcified Tissue International, 95(2), 97-107.
DOI Scopus3 WoS4 Europe PMC4
2014 Fletcher, L., Codrington, J., & Parkinson, I. (2014). Effects of fatigue induced damage on the longitudinal fracture resistance of cortical bone. Journal of Materials Science: Materials in Medicine, 25(7), 1661-1670.
DOI Scopus11 WoS7 Europe PMC5
2013 Wang, J., Zhou, B., Parkinson, I., Thomas, C., Clement, J., Fazzalari, N., & Guo, X. (2013). Trabecular plate loss and deteriorating elastic modulus of femoral trabecular bone in intertrochanteric hip fractures. Bone Research, 4(4), 346-354.
DOI Scopus23 WoS18 Europe PMC15
2013 Mohan, G., Perilli, E., Parkinson, I., Humphries, J., Fazzalari, N., & Kuliwaba, J. (2013). Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort. Osteoarthritis and Cartilage, 21(10), 1595-1604.
DOI Scopus55 WoS54 Europe PMC46
2013 Arthur, A., Panagopoulos, R., Cooper, L., Menicanin, D., Parkinson, I., Codrington, J., . . . Gronthos, S. (2013). EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair. Journal of Bone and Mineral Research, 28(4), 926-935.
DOI Scopus42 WoS38 Europe PMC38
2012 Brennan, O., Kuliwaba, J., Lee, T., Parkinson, I., Fazzalari, N., McNamara, L., & O'Brien, F. (2012). Temporal changes in bone composition, architecture, and strength following estrogen deficiency in osteoporosis. Calcified Tissue International, 91(6), 440-449.
DOI Scopus35 WoS29 Europe PMC27
2012 Parkinson, I., Badiei, A., Stauber, M., Codrington, J., Muller, R., & Fazzalari, N. (2012). Vertebral body bone strength: the contribution of individual trabecular element morphology. Osteoporosis International, 23(7), 1957-1965.
DOI Scopus29 WoS28 Europe PMC21
2012 Perilli, E., Briggs, A., Kantor, S., Codrington, J., Wark, J., Parkinson, I., & Fazzalari, N. (2012). Failure strength of human vertebrae: prediction using bone mineral density measured by DXA and bone volume by micro-CT. Bone, 50(6), 1416-1425.
DOI Scopus76 WoS76 Europe PMC61
2012 Perilli, E., Parkinson, I., & Reynolds, K. (2012). Micro-CT examination of human bone: from biopsies towards the entire organ. Instituto Superiore di Sanita. Annali, 48(1), 75-82.
DOI Scopus44 WoS44 Europe PMC33
2012 Briggs, A., Perilli, E., Parkinson, I., Kantor, S., Wrigley, T., Fazzalari, N., & Wark, J. (2012). Measurement of subregional vertebral bone mineral density in vitro using lateral projection dual-energy X-ray absorptiometry: Validation with peripheral quantitative computed tomography. Journal of Bone and Mineral Metabolism, 30(2), 222-231.
DOI Scopus13 WoS11 Europe PMC9
2012 Cluse, Z., Fudge, A., Whiting, M., Parkinson, I., & O'Loughlin, P. (2012). Evaluation of 25-hydroxy vitamin D assay on the immunodiagnostic systems iSYS analyser. Annals of Clinical Biochemistry, 49(2), 159-165.
DOI Scopus29 WoS28 Europe PMC24
2012 Zarrinkalam, M., Schultz, C., Parkinson, I., & Moore, R. (2012). Osteoporotic characteristics persist in the spine of ovariectomized sheep after withdrawal of corticosteroid administration. Journal of Osteoporosis, 2012, 1-6.
DOI Scopus5 WoS4 Europe PMC4
2012 Ruffoni, D., Wirth, A., Steiner, J., Parkinson, I., Muller, R., & van Lenthe, G. (2012). The different contributions of cortical and trabecular bone to implant anchorage in a human vertebra. Bone, 50(3), 733-738.
DOI Scopus42 WoS41 Europe PMC34
2011 Mohan, G., Perilli, E., Kuliwaba, J., Humphries, J., Parkinson, I., & Fazzalari, N. (2011). Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis. Arthritis Research & Therapy, 13(6), 1-14.
DOI Scopus82 WoS79 Europe PMC72
2010 Briggs, A., Perilli, E., Parkinson, I., Wrigley, T., Fazzalari, N., Kantor, S., & Wark, J. (2010). Novel assessment of subregional bone mineral density using DXA and pQCT, and subregional microarchitecture using micro-CT in whole human vertebrae: Applications, methods, and correspondence between technologies. Journal of Clinical Densitometry, 13(2), 161-174.
DOI Scopus24 WoS21 Europe PMC15
2010 Parkinson, I. H., Forbes, D., Sutton-Smith, P., & Fazzalari, N. L. (2010). Model-independent 3D descriptors of vertebral cancellous bone architecture. Journal of Osteoporosis, 2010, 641578-1-641578-6.
DOI Europe PMC5
2009 Ross, I., Parkinson, I., & Heuzenroeder, M. (2009). The use of MAPLT and MLVA analyses of phenotypically closely related isolates of Salmonella enterica serovar Typhimurium. International Journal of Medical Microbiology, 299(1), 37-41.
DOI Scopus13 WoS9 Europe PMC7
2008 Parkinson, I., Badiei, A., & Fazzalari, N. (2008). Variation in segmentation of bone from micro-CT imaging: implications for quantitative morphometric analysis. Australasian Physical and Engineering Sciences in Medicine, 31(2), 160-164.
DOI Scopus30 WoS28 Europe PMC17
2008 Parkinson, I., & Fazzalari, N. (2008). Whole bone geometry and bone quality in distal forearm fracture. Journal of Orthopaedic Trauma, 22(8), S59-S65.
DOI Scopus11 WoS9 Europe PMC7
2008 Dickson, G., Geddis, C., Fazzalari, N., Marsh, D., & Parkinson, I. (2008). Microcomputed tomography imaging in a rat model of delayed union/non-union fracture. Journal of Orthopaedic Research, 26(5), 729-736.
DOI Scopus21 WoS22 Europe PMC14
2008 Fazzalari, N., Ma, B., Sutton-Smith, P., Kuliwaba, J., Phipps, R., Parkinson, I., & Badiei, A. (2008). Calcium density of bone correlates with trabecular bone architecture. Bone, 42(Suppl 1), S49-S50.
DOI
2006 Fazzalari, N., Parkinson, I., Fogg, Q., & Sutton-Smith, P. (2006). Antero-postero differences in cortical thickness and cortical porosity of T12 to L5 vertebral bodies. Joint Bone Spine, 73(3), 293-297.
DOI Scopus35 WoS32 Europe PMC23
2006 Sutton-Smith, P., Parkinson, I., Linn, A., Kooke, S., & Fazzalari, N. (2006). Trabecular rod buckling index in thoraco-lumbar vertebral bone. Clinical Anatomy, 18(1), 1-7.
DOI Scopus1 WoS2 Europe PMC2
2006 L Fazzalari, N., Parkinson, I. H., Fogg, Q. A., & Sutton-Smith, P. (2006). Anteropostero differences in cortical thickness and cortical porosity of T12 to L5 vertebral bodies{lozenge, open}{lozenge, open}Pour citer cet article, utiliser ce titre en anglais et sa référence dans le même volume de Joint Bone Spine.. Revue Du Rhumatisme Edition Francaise, 73(5), 479-483.
DOI
2004 Branford, S., Rudzki, Z., Parkinson, I., Grigg, A., Taylor, K., Seymour, J., . . . Hughes, T. (2004). Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations. Blood, 104(9), 2926-2932.
DOI Scopus206 WoS179 Europe PMC151
2004 Stevens, M., Milne, A., Parkinson, I., Nespolon, W., Fazzalari, N., Arora, N., & Dodd, T. (2004). Effectiveness of autopapsystem location-guided screening in the evaluation of cervical cytology smears. Diagnostic Cytopathology, 31(2), 94-99.
DOI Scopus10 WoS5 Europe PMC3
2003 Branford, S., Rudzki, Z., Walsh, S., Parkinson, I., Grigg, A., Szer, J., . . . Hughes, T. (2003). Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood, 102(1), 276-283.
DOI Scopus691 WoS598 Europe PMC492
2003 Parkinson, I., & Fazzalari, N. (2003). Interrelationships between structural parameters of cancellous bone reveal accelerated structural change at low bone volume. Journal of Bone and Mineral Research, 18(12), 2200-2205.
DOI Scopus60 WoS57 Europe PMC43
2003 Vijayapalan, V., Sutton-Smith, P., Parkinson, I., Martin, R., & Fazzalari, N. (2003). Trabecular rod thickness by direct measurement from 3D SEM anaglyphs. The Anatomical Record, 271A(2), 286-290.
DOI Scopus9 WoS9 Europe PMC6
2001 Fazzalari, N., Costi, J., Hearn, T., Fraser, R., Vernon-Roberts, B., Hutchinson, J., . . . Sinclair, C. (2001). Mechanical and pathologic consequences of induced concentric anular tears in an ovine model. Spine, 26(23), 2575-2581.
DOI Scopus79 WoS70 Europe PMC61
2001 Simpson, E., Parkinson, I., Manthey, B., & Fazzalari, N. (2001). Intervertebral disc disorganization is related to trabecular bone architecture in the lumbar spine. Journal of Bone and Mineral Research, 16(4), 681-687.
DOI Scopus100 WoS98 Europe PMC84
2001 Fazzalari, N., Manthey, B., & Parkinson, I. (2001). Intervertebral disc disorganisation and its relationship to age adjusted vertebral body morphometry and vertebral bone architecture. The Anatomical Record. Part B: The New Anatomist, 262(3), 331-339.
DOI Scopus26 WoS24 Europe PMC21
2001 Parkinson, I. H., & Fazzalari, N. L. (2001). Structural complexity of cancellous bone: A fractal analysis. BONE, 28(5), S200.
2000 Parkinson, I. H., & Fazzalari, N. L. (2000). Goodness of fit on a modified Richardson plot by residual analysis. Fractals, 8(3), 261-265.
DOI WoS1
2000 Thompson, R. E., Pearcy, M. J., Downing, K. J. W., Manthey, B. A., Parkinson, I. H., & Fazzalari, N. L. (2000). Disc lesions and the mechanics of the intervertebral joint complex. Spine, 25(23), 3026-3035.
DOI Scopus66 WoS51 Europe PMC45
2000 Parkinson, I. H., & Fazzalari, N. L. (2000). Methodological principles for fractal analysis of trabecular bone. Journal of Microscopy, 198(2), 134-142.
DOI Scopus57 WoS50 Europe PMC37
2000 Parkinson, I., & Fazzalari, N. (2000). Fractal analysis of trabecular bone: A standardised methodology. Image Analysis and Stereology, 19(1), 45-49.
DOI Scopus3
1998 Doyle, R., Steele, T., McLennan, A., Parkinson, I., Manning, P., & Heuzenroeder, M. (1998). Sequence analysis of the mip gene of the soilborne pathogen Legionella longbeachae.. Infection and Immunity, 66(4), 1492-1499.
DOI Scopus36 WoS34 Europe PMC22
1998 Fazzalari, N., & Parkinson, I. (1998). Femoral Trabecular Bone of Osteoarthritic and Normal Subjects in an Age and Sex Matched Group. Osteoarthritis and Cartilage, 6(6), 377-382.
DOI Scopus68 Europe PMC55
1998 Fazzalari, N., & Parkinson, I. (1998). Fractal Properties of Cancellous Bone of the Iliac Crest in Vertebral Crush Fracture. Bone, 23(1), 53-57.
DOI Scopus41 Europe PMC26
1997 McNeil, P., Durbridge, T., Parkinson, I., & Moore, R. (1997). Simple method for the simultaneous demonstration of formation and resorption in undecalcified bone embedded in methyl methacrylate. Journal of Histotechnology, 20(4), 307-311.
DOI Scopus5 WoS4
1997 Fazzalari, N., & Parkinson, I. (1997). Fractal properties of subchondral cancellous bone in severe osteoarthritis of the hip. Journal of Bone and Mineral Research, 12(4), 632-640.
DOI Scopus85 Europe PMC54
1996 Fazzalari, N., & Parkinson, I. (1996). Fractal dimension and architecture of trabecular bone. Journal of Pathology, 178(1), 100-105.
DOI Scopus125 Europe PMC73
1996 Smith, P. S., Parkinson, I. H., & Leong, A. S. Y. (1996). Principles of ploidy analysis by static cytometry. Journal of Clinical Pathology Clinical Molecular Pathology, 49(2), M104-M111.
DOI Scopus14
1995 Fazzalari, N., & Parkinson, I. (1995). Fractal properties of iliac crest bone in vertebral crush fracture. Bone, 16, 148S.
1994 Parkinson, I. H., & Fazzalari, N. L. (1994). Cancellous bone structure analysis using image analysis. Australasian Physical and Engineering Sciences in Medicine, 17(2), 64-70.
Scopus26 Europe PMC4
1992 Moore, R. J., Durbridge, T. C., McNcil, P. J., Parkinson, I. H., Need, A. G., & Vernon‐Roberts, B. (1992). Trabecular spacing in post‐menspausal Australian women with and without vertebral fractures. Australian and New Zealand Journal of Medicine, 22(3), 269-273.
DOI Scopus33 Europe PMC21
1992 Matthews, S., Pearcy, M. J., Fazzalari, N. L., Parkinson, I. H., Manthey, B. A., Schultz, C. G., & Howie, D. W. (1992). Correlations between the mechanical properties, radiology and histomorphometry of human femoral bone. Clinical Biomechanics, 7(3), 153-160.
DOI Scopus5 WoS5 Europe PMC3
1991 Parkinson, I. H., Fazzalari, N. L., Durbridge, T. C., & Moore, R. J. (1991). Simplified approach to enzymatic identification of osteoclastic bone resorption. Journal of Histotechnology, 14(2), 81-83.
DOI Scopus7
1990 Fazzalari, N., Vernon-Roberts, B., Manthey, B., & Parkinson, I. (1990). Relationship between changes in articular cartilage and bone in the femoral head in osteoarthritis of the hip. Journal of Orthopaedic Rheumatology, 3(3), 155-169.
Scopus15
1990 Parkinson, I. H., Parsons, A. M., & Moore, R. J. (1990). The histochemic localization of osteoclasts in EDTA decalcified bonee. Journal of Histotechnology, 13(3), 189-191.
DOI Scopus9
1990 Durbridge, T. C., Morris, H. A., Parsons, A. M., Parkinson, I. H., Moore, R. J., Porter, S., . . . Vernon-Roberts, B. (1990). Progressive cancellous bone loss in rats after adrenalectomy and oophorectomy. Calcified Tissue International, 47(6), 383-387.
DOI Scopus48 WoS43 Europe PMC30
1990 Crane, G. J., Fazzalari, N. L., Parkinson, I. H., & Vernon-Roberts, B. (1990). Age-related changes in femoral trabecular bone in arthrosis. Acta Orthopaedica, 61(5), 421-426.
DOI Scopus37 WoS34 Europe PMC26
1986 Parkinson, I., & Daymon, M. (1986). A method for producing artificial spirochete control material. Journal of Histotechnology, 9(4), 247-248.
DOI

Year Citation
2014 Fletcher, L., Codrington, J., & Parkinson, I. (2014). Methods for assessing the effects of accumulated fatigue damage on the fracture resistance of cortical bone. In 8th Australasian Congress on Applied Mechanics, ACAM 2014, as Part of Engineers Australia Convention 2014 (pp. 167-175). online / CD: Engineers Australia.
2012 Fletcher, L., Codrington, J., & Parkinson, I. (2012). Effects of irradiation and non-enzymatic glycation on the fracture resistance of bovine cortical bone. In Proceedings of the 7th Australasian Congress on Applied Mechanics, ACAM 7 (pp. 322-330). CDROM / DVDROM: Engineers Australia.
Scopus1
2011 Perilli, E., Briggs, A. M., Codrington, J. D., Kantor, S., Parkinson, I. H., Fazzalari, N. L., & Wark, J. D. (2011). WHOLE VERTEBRAL BODY STRENGTH PREDICTED BY BONE MINERAL DENSITY FROM DXA AND BY BONE MICROARCHITECTURE FROM MICRO-CT. In OSTEOPOROSIS INTERNATIONAL Vol. 22 (pp. S542). Gold Coast, AUSTRALIA: SPRINGER LONDON LTD.
WoS1
2009 Parkinson, I. H., Badiei, A., Stauber, M., Muller, R., & Fazzalari, N. L. (2009). Trabecular rod and plate morphology improves prediction of vertebral body bone strength beyond apparent bone density. In BONE Vol. 44 (pp. S112). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2009 Perilli, E., Briggs, A. M., Wark, J. D., Kantor, S., Parkinson, I. H., & Fazzalari, N. L. (2009). Whole human vertebral body BMD and bone volume fraction examined by DXA and micro-CT. In BONE Vol. 44 (pp. S375). Vienna, AUSTRIA: ELSEVIER SCIENCE INC.
DOI
2009 Perilli, E., Briggs, A. M., Wark, J. D., Kantor, S., Parkinson, I. H., & Fazzalari, N. L. (2009). BMD and bone volume fraction of entire human vertebral bodies examined by DXA and micro-CT. In BONE Vol. 44 (pp. S97-S98). Sydney, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2006 Parkinson, I. H., Badiei, A., & Fazzalari, N. L. (2006). Independent predictors of human vertebral body bone strength.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 21 (pp. S409). Philadelphia, PA: AMER SOC BONE & MINERAL RES.
2003 Smith, P., Fazzalari, N. L., & Parkinson, I. H. (2003). Vertebral body bone architecture measurement using 3D anaglyphs. In BONE Vol. 32 (pp. S179). OSAKA, JAPAN: ELSEVIER SCIENCE INC.

Year Citation
2008 Ma, B., Parkinson, I. H., Badiei, A., Cotton, N. J., & Fazzalari, N. L. (2008). Non-invasive comparison of poly lactide carbonate implants with different additives on bone formation in ovariectomised rats. Poster session presented at the meeting of Abstracts of the 35th European Symposium on Calcified Tissues, as published in Calcified Tissue International. Barcelona, Spain: Springer-Verlag.
DOI
2000 Wilson, D., Crowley, C., Gardner, J., Wilson, M., Wilson, M., Wiebkin, O., . . . Fazzalari, N. (2000). Trabecular bone architecture of the human temporomandibular joint. Poster session presented at the meeting of Journal of Dental Research Vol 79 (5) May 2000. VA, USA: International Assoc for Dental Research.
2000 Wiebkin, O., Gardner, J., Wilson, M., Wilson, M., Parkinson, I., Fazzalari, N., & Wilson, D. (2000). Quantitation of the trabecular structure of the condyle: a study of temporomandibular joints. Poster session presented at the meeting of Abstracts XVIIth meeting of the Federation of the European Connective Tissue Societies. Greece: Hellenic Connective Tissue Club.
2000 Wilson, D., Crowley, C., Gardner, J., Wilson, M., Wilson, M., Wiebkin, O., . . . Fazzalari, N. (2000). Quantification of the architecture of the condyle of Human temporomandibular (Joint). Poster session presented at the meeting of Proceedings of The Human Skeleton - from molecules to structure and function. South Australia: Div of Tissue Pathology IMVS, Dept of Orthopaedics & Trauma Adelaide University.

Date Role Research Topic Program Degree Type Student Load Student Name
2012 - 2015 Co-Supervisor Fatigue Fracture Interaction Mechanisms in Cortical Bone Doctor of Philosophy Doctorate Full Time Lloyd Colin Fletcher
2012 - 2015 Co-Supervisor Corticotomy-Assisted Orthodontics Doctor of Clinical Dentistry Doctorate Full Time Dr Nida Khan
2010 - 2013 Co-Supervisor Biological Response to Corticotomy-Assisted Orthodontics Doctor of Clinical Dentistry Doctorate Full Time Dr Cherry Zaw
2009 - 2012 Co-Supervisor Corticotomy Enhanced Orthodontics Doctor of Clinical Dentistry Doctorate Full Time Dr Mun Jing Jong
2008 - 2012 Co-Supervisor Mechanisms of Osteoarthritis: Interrelationships between Bone and Cartilage Doctor of Philosophy Doctorate Full Time Miss Geetha Mohan

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