Associate Professor Iain Searle
Associate Prof/Reader
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
Epigenetic and post-transcriptional gene regulation
Our research in plant and animal epigenetics and RNA modifications has been driven by a strong interest in understanding and elucidating the molecular mechanisms of how plants and animals adapt to environmental signalling and how speciation barriers evolve in plants. We use a combination of next-generation sequencing, bioinformatics and synthetic biology to describe and elucidate the function of these epigenetic components.
Epigenetics, broadly defined, refers to all genetic information not encoded in the DNA sequence, with the best-understood consequence of epigenetic modifications being the regulation of gene expression. Although gene transcription and protein synthesis is required for plant development, the full repertoire of epigenetic mechanisms underpinning biological adaptation and speciation barriers remain equivocal.
The majority of the genome is pervasively transcribed such that more than 90% of transcriptional activity is related to the production of various long non-coding RNAs (lncRNA), which possess no or limited protein-coding capacity. Expansion of these transcriptionally active non-coding sequences in plant and animal genomes appears to have occurred primarily in higher multicellular organisms. We have identified thousands of novel lncRNAs transcribed in plants.
Furthermore, we have demonstrated RNA modifications, for example 5-methylcytosine (m5C) play an important role in extending the transcriptional space. Thus, both RNA modifications and lncRNAs represent attractive candidates for achieving context- and stimulus-specific epigenetic regulation of gene expression.
Honours, Masters, PhD and postdoctoral synthetic biology and biotechnology projects in epigenetics and bioinformatics are available. Email me at, iain.searle@adelaide.edu.au, for further information.
Developing sustainable biocontrols for agricultural and horticultural diseases
20% to 40% of global crop production is lost to pests, and plant diseases cost the global economy over $200 billion annually. Crown gall disease caused by Agrobacterium and related spp. like Allorhizobium can significantly reduce the yield of infected trees, examples include almonds and walnuts, and young grapevines.
Crown gall disease in young grapevines is a global problem in nurseries and vineyards. Symptoms include gall formation at graft and wound sites, stunted growth and in later stages of the disease progression decline in vine vigour and yield. As there is currently no cure, we are developing the next generation of sustainable, environmentally friendly, biocontrols with cutting-edge technologies like CRISPR and third-generation sequencing.
There are a range of biochemistry and synthetic biology projects available.
Honours, Masters, PhD and postdoctoral CRISPR and biotechnology projects in are available. Email me at, iain.searle@adelaide.edu.au, for further information.
Relevant papers from our group characterising grapevine crown gall pathogenic and non-pathogenic strains
(1) Genome sequence of Grapevine Crown Gall pathogenic strain A. vitis K306
(2) Genome sequence of Grapevine Crown Gall pathogenic strain A. vitis K377
(3) Genome sequence of nonpathogenic A. vitis F2/5
Relevant peer-reviewed research from our collaborators
(1) PhD thesis on Biological control of Crown Gall Disease in Australian Grape vine nurseries (2001)- of Dr. Alex Keegan. Former student of collaborator Prof. Allen Kerr
(2) Detection of pathogenic A. vitis in grapevines (2016)- Collaborator Prof. Thomas Burr
(3) Biochemical characterisation of crown gall compounds (1984)- Collaborator Dr. Maarten Ryder
Sustainable crops for arid Australia
Australia is a hot, dry country and often water limits crop yields. We are developing Common Vetch, Vicia sativa, as a high protein, drought tolerant legume for arid Australia. We are accelerating common vetch improvement by; developing extensive genomic resources using a combination of second and third generation sequencing and bioinformatics, combining these large datasets with phenotyping information, and then using next generation breeding technologies (NBT), like CRISPR genome editing. We are working closely with the National Vetch Breeding program at SARDI (Waite campus) to further develop vetch.
Honours, Masters, PhD and postdoctoral CRISPR and biotechnology projects in are available. Email me at, iain.searle@adelaide.edu.au, for further information.
Pollination Mechanisms
We are interested in how plants promote outcrossing to increase population fitness. We are using the model crop Brassica rapa to solve the molecular basis of an outcrossing mechanism. Conversely, these outcrossing mechanisms can decrease seed and crop yields and we are working with industrial partners to determine if we can increase crops yields.
Honours, Masters, PhD and postdoctoral ecology and industry projects in are available. Email me at, iain.searle@adelaide.edu.au, for further information.
Interested in joining our laboratory as an undergraduate placement student or postgraduate student? What to join our mentor programme? Ready to excel and be challenged with fascinating biological questions? Please don't hesitate to email me- iain.searle@adelaide.edu.au.
Publications
Our group's publications are available here.
Contact
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Appointments
Date Position Institution name 2018 - ongoing Senior Lecturer University of Adelaide 2014 - 2018 ARC Future Fellow University of Adelaide 2009 - 2014 ARC QEII Fellow Australian National University -
Language Competencies
Language Competency German Can speak and understand spoken -
Education
Date Institution name Country Title 2004 University of Queensland Australia PhD 1996 University of Queensland Australia B Ag Sci Hons -
Postgraduate Training
Date Title Institution Country 2007 - 2009 Wellcome Trust VIP Fellow University of Cambridge United Kingdom 2006 - 2007 Marie Curie Postdoctoral Fellow The Sainsbury Laboratory United Kingdom 2002 - 2006 Max Planck Postdoctoral Fellow Max Planck Institute for Plant Breeding Research Germany
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Journals
Year Citation 2025 Zhao, L., Ma, X., Ma, W., Wang, Z., Luo, D., Zhou, Q., . . . Liu, Z. (2025). MsPYL6 and MsPYL9 improves drought tolerance by regulating stomata in alfalfa (Medicago sativa). The Plant Journal, 122(6), e70265-1-e70265-16.
2024 Li, M., Pu, J., Jia, C., Luo, D., Zhou, Q., Fang, X., . . . Liu, Z. (2024). The genome of Vicia sativa ssp. amphicarpa provides insights into the role of terpenoids in antimicrobial resistance within subterranean fruits. Plant Journal, 119(6), 2654-2671.
2024 Xue, F., Zhang, J., Wu, D., Sun, S., Fu, M., Wang, J., . . . Liang, W. (2024). m<sup>6</sup>A demethylase OsALKBH5 is required for double-strand break formation and repair by affecting mRNA stability in rice meiosis.. The New phytologist, 244(6), 2326-2342.
Scopus3 Europe PMC12023 Chmielowska-Bąk, J., Searle, I. R., Wakai, T. N., & Arasimowicz-Jelonek, M. (2023). The role of epigenetic and epitranscriptomic modifications in plants exposed to non-essential metals. Frontiers in Plant Science, 14, 1278185-1-1278185-14.
Scopus5 Europe PMC52023 Safdar, L. B., Dugina, K., Saeidan, A., Yoshicawa, G. V., Caporaso, N., Gapare, B., . . . Fisk, I. D. (2023). Reviving grain quality in wheat through non‐destructive phenotyping techniques like hyperspectral imaging. Food and Energy Security, 12(5), 1-21.
Scopus10 Europe PMC32023 Safdar, L. B., Foulkes, M. J., Kleiner, F. H., Searle, I. R., Bhosale, R. A., Fisk, I. D., & Boden, S. A. (2023). Challenges facing sustainable protein production: Opportunities for cereals. Plant Communications, 4(6), 100716-1-100716-15.
Scopus33 Europe PMC122023 Nguyen, V., & Searle, I. (2023). Keeping it cool.. eLife, 12, e86885.
Scopus12022 Xi, H., Grist, J., Ryder, M., & Searle, I. (2022). Complete Genome Sequence Data of the Grapevine Crown Gall inhibiting bacteria Allorhizobium vitis Strain F2/5.. Mol Plant Microbe Interact, 35(2), 174-176.
Scopus12022 Nguyen, V., & Searle, I. R. (2022). An efficient root transformation system for recalcitrant Vicia sativa. Frontiers in Plant Science, 12, 781014-1-781014-11.
Scopus3 WoS3 Europe PMC22022 Xi, H., Nguyen, V., Ward, C., Liu, Z., & Searle, I. R. (2022). Chromosome-level assembly of the common vetch (Vicia sativa) reference genome. Gigabyte, 2022, 1-19.
Scopus13 Europe PMC122022 Li, M., Zhao, L., Zhou, Q., Fang, L., Luo, D., Liu, W., . . . Liu, Z. (2022). Transcriptome and Coexpression Network Analyses Provide In-Sights into the Molecular Mechanisms of Hydrogen Cyanide Synthesis during Seed Development in Common Vetch (Vicia sativa L.). International Journal of Molecular Sciences, 23(4), 2275-1-2275-15.
Scopus5 WoS4 Europe PMC22022 Dixon, L. E., Pasquariello, M., Badgami, R., Levin, K. A., Poschet, G., Ng, P. Q., . . . Boden, S. A. (2022). MicroRNA-resistant alleles of HOMEOBOX DOMAIN-2 modify inflorescence branching and increase grain protein content of wheat. Science Advances, 8(19), 1-16.
Scopus27 WoS7 Europe PMC122022 Riley, S., Lale, A., Nguyen, V., Xi, H., Wilkinson, K., Searle, I. R., & Fisk, I. (2022). Volatile profiles of commercial vetch prepared via different processing methods. Food Chemistry, 395, 15 pages.
Scopus5 WoS1 Europe PMC32021 David, R., Ng, P. Q., Smith, L. M., & Searle, I. R. (2021). Novel allele <i>elh</i> of the <i>UBP14</i> gene affects plant organ size via cell expansion in <i>Arabidopsis thaliana.</i>. microPublication biology, 2021.
Europe PMC22021 Xi, H., Ryder, M., & Searle, I. R. (2021). Near-Complete Genome Assembly of the Grapevine Crown Gall Pathogen Allorhizobium vitis Strain K377. Microbiology Resource Announcements, 10(39), 1-2.
Scopus22021 Xi, H., Nguyen, V., Ward, C., Liu, Z., & Searle, I. (2021). Chromosome-level assembly of the common vetch reference genome (Vicia sativa). GIGABYTE, 2022, 19 pages.
2021 Lim, S. M., Choo, J. M., Li, H., O'Rielly, R., Carragher, J., Rogers, G. B., . . . Muhlhausler, B. (2021). A high amylose wheat diet improves gastrointestinal health parameters and gut microbiota in male and female mice. Foods, 10(2), 1-18.
Scopus10 WoS6 Europe PMC62021 Jia, C., Dong, D., Zhou, Q., Searle, I. R., & Liu, Z. (2021). Significant cell difference of pod ventral suture in shatter‐resistant and shatter‐susceptible common vetch accessions. Crop Science, 61(3), 1-11.
Scopus6 WoS32020 Sinha, P., Singh, V. K., Saxena, R. K., Kale, S. M., Li, Y., Garg, V., . . . Varshney, R. K. (2020). Genome-wide analysis of epigenetic and transcriptional changes associated with heterosis in pigeonpea.. Plant biotechnology journal, 18(8), 1697-1710.
Scopus49 WoS24 Europe PMC312020 Nguyen, V., & Searle, I. R. (2020). An efficient root transformation system for recalcitrant<i>Vicia sativa</i>.
2020 Xi, H., Ryder, M., & Searle, I. (2020). Complete genome sequence of Allorhizobium vitis strain K306, the causal agent of grapevine crown gall. Microbiologial Resource Annoucements, 9(29), e00565-20-1-e00565-20-3.
Scopus3 WoS2 Europe PMC12020 Nguyen, V., Riley, S., Nagel, S., Fisk, I., & Searle, I. R. (2020). Common vetch: a drought tolerant, high protein neglected leguminous crop with potential as a sustainable food source. Frontiers in Plant Science, 11, 818-1-818-7.
Scopus27 WoS19 Europe PMC172020 Xiao, L., Jiang, S., Huang, P., Chen, F., Wang, X., Cheng, Z., . . . Zhang, X. -M. (2020). Two Nucleoporin98 homologous genes jointly participate in the regulation of starch degradation to repress senescence in Arabidopsis. BMC Plant Biology, 20(1), 292-1-292-15.
Scopus13 WoS12 Europe PMC102019 Lim, S. M., Page, A. J., Li, H., Carragher, J., Searle, I., Robertson, S., & Muhlhausler, B. (2019). Sexually Dimorphic Response of Increasing Dietary Intake of High Amylose Wheat on Metabolic and Reproductive Outcomes in Male and Female Mice.. Nutrients, 12(1), 14 pages.
Scopus4 WoS1 Europe PMC32019 Guo, Q., Ng, P. Q., Shi, S., Fan, D., Li, J., Zhao, J., . . . Searle, I. R. (2019). Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth. PLoS ONE, 14(11), 1-26.
Scopus20 WoS14 Europe PMC162019 David, R., Kortschak, R. D., & Searle, I. R. (2019). The root hair defective phenotype of Arabidopsis thaliana Pol IV subunit mutant nrpd1a-3 is associated with a deletion in RHD6. microPublication Biology, 2019, 1-4.
Europe PMC32018 Wang, D., Gu, J., David, R., Wang, Z., Yang, S., Searle, I., . . . Timmis, J. (2018). Experimental reconstruction of double-stranded break repair-mediated plastid DNA insertion into the tobacco nucleus. The Plant Journal, 93(2), 227-234.
Scopus8 WoS3 Europe PMC62017 Crisp, P., Ganguly, D., Smith, A., Murray, K., Estavillo, G., Searle, I., . . . Pogson, B. (2017). Rapid recovery gene downregulation during excess-light stress and recovery in Arabidopsis. The Plant Cell, 29(8), 1836-1863.
Scopus74 WoS61 Europe PMC682017 Liu, L., Jiang, Y., Zhang, X., Wang, X., Wang, Y., Han, Y., . . . Chen, F. (2017). Two SUMO proteases SUMO PROTEASE RELATED TO FERTILITY1 and 2 are required for fertility in arabidopsis. Plant Physiology, 175(4), 1703-1719.
Scopus34 WoS28 Europe PMC252017 David, R., Burgess, A., Parker, B., Li, J., Pulsford, K., Sibbritt, T., . . . Searle, I. (2017). Transcriptome-wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and non-coding RNAs. The Plant cell, 29(3), 16.00751-1-16.0075-30.
Scopus194 WoS148 Europe PMC1622017 Wang, D., Qu, Z., Yang, L., Zhang, Q., Liu, Z., Do, T., . . . Zhu, J. (2017). Transposable elements (TEs) contribute to stress-related long intergenic noncoding RNAs in plants. Plant Journal, 90(1), 133-146.
Scopus126 WoS95 Europe PMC792016 Ashby, R., Forêt, S., Searle, I., & Maleszka, R. (2016). MicroRNAs in Honey Bee Caste Determination. Scientific Reports, 6(1), 15 pages.
Scopus112 WoS80 Europe PMC692016 Burgess, A., David, R., & Searle, I. (2016). Deciphering the epitranscriptome: a green perspective. Journal of Integrative Plant Biology, 58(10), 822-835.
Scopus31 WoS30 Europe PMC212016 Chen, M., Xu, J., Devis, D., Shi, J., Ren, K., Searle, I., & Zhang, D. (2016). Origin and functional prediction of pollen allergens in plants. Plant Physiology, 172(1), 341-357.
Scopus30 WoS24 Europe PMC152015 Burgess, A., David, R., & Searle, I. (2015). Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae. BMC Plant Biology, 15(1), 199-1-199-17.
Scopus93 WoS80 Europe PMC722015 Liu, H., Searle, I., Mather, D., Able, A., & Able, J. (2015). Morphological, physiological and yield responses of durum wheat to pre-anthesis water-deficit stress are genotype-dependent. Crop and Pasture Science, 66(10), 1024-1038.
Scopus72 WoS512015 Liu, H., Searle, I., Watson-Haigh, N., Baumann, U., Mather, D., Able, A., & Able, J. (2015). Genome-wide identification of microRNAs in leaves and the developing head of four durum genotypes during water deficit stress. PLoS One, 10(11), e0142799-1-e0142799-30.
Scopus48 WoS41 Europe PMC282013 Cazzonelli, C., Vanstraelen, M., Simon, S., Yin, K., Carron-Arthur, A., Nisar, N., . . . Pogson, B. (2013). Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. PLoS One, 8(7), 1-14.
Scopus72 WoS51 Europe PMC442012 Campoli, C., Drosse, B., Searle, I., Coupland, G., & von Korff, M. (2012). Functional characterisation of HvCO1, the barley (Hordeum vulgare) flowering time ortholog of CONSTANS. The Plant Journal, 69(5), 868-880.
Scopus134 WoS112 Europe PMC962011 Gursanscky, N. R., Searle, I. R., & Carroll, B. J. (2011). Mobile microRNAs hit the target. Traffic, 12(11), 1475-1482.
Scopus12 WoS11 Europe PMC72011 Burgess, A., & Searle, I. R. (2011). The clock primes defense at dawn. Immunology and Cell Biology, 89(6), 661-662.
Scopus4 WoS4 Europe PMC32011 Indrasumunar, A., Searle, I., Lin, M., Kereszt, A., Men, A., Carroll, B., & Gresshoff, P. (2011). Nodulation factor receptor kinase 1α controls nodule organ number in soybean (Glycine max L. Merr). The Plant Journal, 65(1), 39-50.
Scopus118 WoS96 Europe PMC842011 Castro Marín, I., Loef, I., Bartetzko, L., Searle, I., Coupland, G., Stitt, M., & Osuna, D. (2011). Nitrate regulates floral induction in Arabidopsis, acting independently of light, gibberellin and autonomous pathways. Planta, 233(3), 539-552.
Scopus166 WoS132 Europe PMC992010 Searle, I. R., Pontes, O., Melnyk, C. W., Smith, L. M., & Baulcombe, D. C. (2010). JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis. Genes and Development, 24(10), 986-991.
Scopus98 WoS88 Europe PMC812010 Indrasumunar, A., Kereszt, A., Searle, I., Miyagi, M., Li, D., Nguyen, C. D. T., . . . Gresshoff, P. M. (2010). Inactivation of duplicated nod factor receptor 5 (NFR5) genes in recessive loss-of-function non-nodulation mutants of allotetraploid soybean (Glycine max L. Merr.). Plant and Cell Physiology, 51(2), 201-214.
Scopus109 WoS93 Europe PMC752009 Huang, L., Jones, A. M. E., Searle, I., Patel, K., Vogler, H., Hubner, N. C., & Baulcombe, D. C. (2009). An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II. Nature Structural and Molecular Biology, 16(1), 91-93.
Scopus116 WoS100 Europe PMC932007 Corbesier, L., Vincent, C., Jang, S., Fornara, F., Fan, Q., Searle, I., . . . Coupland, G. (2007). FT protein movement contributes to long-distance signaling in floral induction of Arabidopsis. Science, 316(5827), 1030-1033.
Scopus1811 WoS1531 Europe PMC13302007 Smith, L. M., Pontes, O., Searle, I., Yelina, N., Yousafzai, F. K., Herr, A. J., . . . Baulcombe, D. C. (2007). An SNF2 protein associated with nuclear RNA silencing and the spread of a silencing signal between cells in Arabidopsis. Plant Cell, 19(5), 1507-1521.
Scopus242 WoS206 Europe PMC1972006 Searle, I., He, Y., Turck, F., Vincent, C., Fornara, F., Kröber, S., . . . Coupland, G. (2006). The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. Genes and Development, 20(7), 898-912.
Scopus726 WoS614 Europe PMC5522006 Corbesier, L., Vincent, C., Searle, I., Fomara, F., & Coupland, G. (2006). Analysis of the expression pattern of FT protein during flowering. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S166. 2006 SEARLE, I. (2006). The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. Genes Dev., 20, 898-912. 2006 SEARLE, I. (2006). The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. Genes Dev, 20, 898-912. 2006 SEARLE, I. (2006). The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. Genes Dev., 20, 898-912. 2005 Berendzen, K., Searle, I., Ravenscroft, D., Koncz, C., Batschauer, A., Coupland, G., . . . Ülker, B. (2005). A rapid and versatile combined DNA/RNA extraction protocol and its application to the analysis of a novel DNA marker set polymorphic between Arabidopsis thaliana ecotypes Col-0 and Landsberg erecta. Plant Methods, 1(1), 15 pages.
Scopus66 WoS54 Europe PMC542004 Searle, I., & Coupland, G. (2004). Induction of flowering by seasonal changes in photoperiod. EMBO Journal, 23(6), 1217-1222.
Scopus235 WoS208 Europe PMC1492003 Searle, I. R., Men, A. E., Laniya, T. S., Buzas, D. M., Iturbe-Ormaetxe, I., Carroll, B. J., & Gresshoff, P. M. (2003). Long-distance signaling in nodulation directed by a CLAVATA1-like receptor kinase. Science, 299(5603), 109-112.
Scopus459 WoS402 Europe PMC3162003 Waldron, J., Peace, C. P., Searle, I. R., Furtado, A., Wade, N., Findlay, I., . . . Carroll, B. J. (2003). Randomly Amplified DNA Fingerprinting: A culmination of DNA marker technologies based on arbitrarily-primed PCR amplification. Journal of Biomedicine and Biotechnology, 2(3), 141-150.
Scopus21 Europe PMC142003 SEARLE, I. R. (2003). Long-distance signaling in nodulation directed by a CLAVATA1-like receptor kinase. Science, 299, 109-112. 2003 SEARLE, I. R. (2003). Long-distance signaling in nodulation directed by a CLAVATA1-like receptor kinase. Science, 299, 109-112. 2002 May, K. J., Whisson, S. C., Zwart, R. S., Searle, I. R., Irwin, J. A. G., Maclean, D. J., . . . Drenth, A. (2002). Inheritance and mapping of 11 avirulence genes in Phytophthora sojae. Fungal Genetics and Biology, 37(1), 1-12.
Scopus54 WoS45 Europe PMC412002 Waldron, J., Peace, C. P., Searle, I. R., Furtado, A., Wade, N., Findlay, I., . . . Carroll, B. J. (2002). Randomly amplified DNA fingerprinting: A culmination of DNA marker technologies based on arbitrarily-primed PCR amplification. Journal of Biomedicine and Biotechnology, 2002(3), 141-150.
Scopus182001 SEARLE, I. R. (2001). Unknown Title. Towards the map-based cloning of nodulation genes from soybean. 1999 Schenk, G., Ge, Y., Carrington, L. E., Wynne, C. J., Searle, I. R., Carroll, B. J., . . . De Jersey, J. (1999). Binuclear metal centers in plant purple acid phosphatases: Fe-Zn in sweet potato and Fe-Zn in soybean. Archives of Biochemistry and Biophysics, 370(2), 183-189.
Scopus151 WoS134 Europe PMC881984 STEVENS, J. E., FUJINAGA, M., OSHIMA, E., & MORI, K. (1984). THE BIPHASIC PATTERN OF THE CONVULSIVE PROPERTY OF ENFLURANE IN CATS. BRITISH JOURNAL OF ANAESTHESIA, 56(4), 395-403.
WoS26 Europe PMC16 -
Book Chapters
Year Citation 2021 Li, J., Wu, X., Do, T., Nguyen, V., Zhao, J., Ng, P. Q., . . . Searle, I. (2021). Quantitative and Single-Nucleotide Resolution Profiling of RNA 5-Methylcytosine. In Methods in Molecular Biology (Vol. 2298, pp. 135-151). Springer US.
DOI Scopus12021 Samuelson, M. (2021). ‘Re-enchanting the world’ from Mozambique: The African Anthropocene and Mia Couto’s poetics of the planet. In Transcultural Ecocriticism Global Romantic and Decolonial Perspectives (pp. 63-81).
Scopus12019 Do, T., Qu, Z., & Searle, I. R. (2019). Purification and functional analysis of plant long noncoding RNAs (lncRNA). In J. Chekanova, & H. -L. Wang (Eds.), Plant long non-coding RNAs: methods and protocols (Vol. 1933, pp. 131-147). New York: Springer.
DOI Scopus5 Europe PMC6 -
Conference Papers
Year Citation 2017 Yang, S. Y., Tate, M., Asenstorfer, R., Carragher, J., Paull, J., & Searle, I. (2017). Progress Towards Developing Low Toxin Common Vetch (Vicia sativa L.). In BIT’s 5th World Congress of Agriculture-2017. Shenyang, China. 2007 Searle, I. R., Mosher, R. A., Melnyk, C. W., & Baulcombe, D. C. (2007). Small RNAs hit the big time: Meetings. In New Phytologist Vol. 174 (pp. 479-482). England: WILEY.
DOI -
Conference Items
Year Citation 2016 Liu, H., Able, A., Searle, I., & Able, J. (2016). Characterising water deficit stress-responsive microRNAs and their functional targets in different durum wheat genotypes. Poster session presented at the meeting of ComBio 2016. Brisbane, Australia.. 2015 Liu, H., Searle, I., Watson-Haigh, N., Baumann, U., Mather, D., Able, A., & Able, J. (2015). Identification of differentially expressed miRNAs and their targets in durum wheat during water deficit stress. Poster session presented at the meeting of 9th International Wheat Conference. Sydney, Australia.. 2015 David, R., Lim, H. M., & Searle, I. R. (2015). Identification of pla/ubp14, an Arabidopsis mutant that displays lengthened plastochron and larger organs. Poster session presented at the meeting of Annual Genetics Society of Australasia conference. -
Theses
Year Citation 2016 Liu, H. (2016). Genome-wide characterisation of microRNAs and their target genes in different durum wheat genotypes under water limiting conditions. (PhD Thesis, University of Adelaide). -
Datasets
Year Citation 2015 Liu, H., Searle, I., Watson-Haigh., Baumann., Mather, D. E., Able, A. J., & Able, J. A. (2015). Genome-wide identification of differentially expressed microRNAs in leaves and the developing head of four durum genotypes during water deficit stress. -
Preprint
Year Citation 2025 Riley, S., Nguyen, V., Bhattacharjee, R., Ng, P. Q., Ritchie, T., Fisk, I., . . . Searle, I. R. (2025). TMT-based quantitative proteomic assessment of<i>Vicia sativa</i>induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.
DOI2025 Xi, H., Llamas, B., Nguyen, V., Li, M., Zhou, Q., Liu, Z., & Searle, I. (2025). Two routes from the Fertile Crescent led to the introduction of common vetch into Europe.
DOI2024 Wu, X., Keith Bullard, G., & Searle, I. (2024). A Quantitative Bioassay for Crown-Gall Tumourigenesis using Carrot Disks v1.
DOI2018 Xu, K., Zhang, X. -M., Yu, G., Lu, M., Liu, C., Chen, H., . . . Fu, Y. -F. (2018). <i>FT/FD-GRF5</i> repression loop directs growth to increase soybean yield.
DOI
- Competitive funding only listed below (since 2014)
- ARC Linage project-Chief Investigators Searle et al., Industry partner SAGIT (2021-2025)
- Yitpi foundation grant- Chief Investigators Searle and Nguyen (2020)
- SAGIT grant- Investigators Searle and Nagel (2020-2023)
- ARC Discovery Grant DP190101303- Investigators Searle and Studholme (2019-2021)
- Hermon Slade Foundation- Investigator Searle (2017-2020)
- ACSRF Australia-China Joint Research Centre of Grains for Health- Investigators, Searle, et al (2016-2019)
- ARC Future Fellowship FT130100525- Investigator Searle (2014-2018)
- ASTE Travel Grant- Investigator Searle (2015)
- ACSRF Australia-China Young Scientists Exchange Programme- Investigator Searle (2014)
- Interim UOC-UA Biotechnology program coordinator
- BIOTECH 7040- Coordinator for Applications of Next Generation Sequencing
- GENETICS 2510- Genetics IIA
- GENETICS 3211- Gene Expression & Human Developmental Genetics III
- SCIENCE 3500- Opening Doors to the Middle Kingdom
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Principal Supervisor Role of an allele involving in stamen orientation of oilseed plant flowers that causes higher seed yield Doctor of Philosophy Doctorate Full Time Mr Jun Ming Loke 2023 Co-Supervisor Characterising Physiological and Biochemical Traits in Shiraz Grapevines of Varying Vine Age in Barossa Valley Geographical Indication Doctor of Philosophy Doctorate Full Time Ms Grace Puspita Prayogo 2022 Principal Supervisor Does RNA m5C Regulate Post-Transcriptional Gene Expression in Plants? Doctor of Philosophy Doctorate Full Time Mr Jasjyot Singh Khanduja 2022 Principal Supervisor Development of drought tolerant, high protein legume for arid Australia Doctor of Philosophy Doctorate Full Time Ms Junyi Wang 2020 Co-Supervisor Understanding the physiological and molecular regulation of protein content variation in wheat grain Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Mr Luqman Bin Safdar -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2020 - 2024 Principal Supervisor Construction of the Vicia sativa (common vetch) reference genome and exploration of genetic resources Doctor of Philosophy Doctorate Full Time Mr Hangwei Xi 2019 - 2021 Principal Supervisor The role of RNA modifications in Arabidopsis thaliana growth and development Doctor of Philosophy Doctorate Full Time Dr Pei Qin Ng 2019 - 2023 Principal Supervisor Vetch as a New Protein Source for the Human Diet Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Mr Samuel Arthur George Riley 2018 - 2021 Principal Supervisor The Genetic Basis of Stamen Orientation - An Outcrossing Mechanism in the Brassicaceae Master of Philosophy Master Full Time Mrs Jayashrini Sakunthala Madawala 2018 - 2022 Principal Supervisor Towards site-specific functional analysis of RNA N6-methyladenosine and 5-methylcytosine in Arabidopsis thaliana Doctor of Philosophy Doctorate Full Time Miss Huong Thi Thuy Ta 2017 - 2021 Co-Supervisor Development and application of genomic approaches for resolving complex traits among insect pests Doctor of Philosophy Doctorate Full Time Mr Christopher Michael Ward 2017 - 2021 Principal Supervisor Determining the molecular basis of beta-cyano-alanine and gamma-glutamyl-beta-cyano-alanine toxin accumulation in Vicia sativa Doctor of Philosophy Doctorate Full Time Dr Vy Hoang Thao Nguyen 2017 - 2023 Principal Supervisor Characterizing RNA 5-methylcytosine in A. thaliana: Functions and Regulation Pathways Doctor of Philosophy Doctorate Full Time Miss Xingyu Wu 2016 - 2019 Co-Supervisor Don't Cry for Me: Evolutionary and Functional Analysis of Two Rice Pollen Allergens, Ory s 1 and Ory s 12 Doctor of Philosophy Doctorate Full Time Ms Deborah Devis 2016 - 2020 Principal Supervisor Identification and functional analysis of RNA modifications in Arabidopsis thaliana and Mus musculus Doctor of Philosophy Doctorate Full Time Miss Jun Li 2016 - 2023 Principal Supervisor Investigating the role of RNA 5-methylcytosine on ribosomal and transfer RNAs in Arabidopsis thaliana Doctor of Philosophy Doctorate Full Time Miss Jing Zhao 2014 - 2018 Principal Supervisor Identification and Functional Characterization of Long Noncoding RNAs Involved in Endosperm Development of Arabidopsis thaliana Doctor of Philosophy Doctorate Full Time Mr Quang Trung Do 2013 - 2016 Co-Supervisor Genome-wide Characterisation of microRNAs and their target genes in different durum wheat genotypes under water limiting conditions Doctor of Philosophy Doctorate Full Time Dr Haipei Liu 2013 - 2016 Principal Supervisor Conservation and Function of RNA 5-methylcytosine in Plants Doctor of Philosophy Doctorate Full Time Miss Alice Louise Burgess
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Editorial Boards
Date Role Editorial Board Name Institution Country 2011 - ongoing Consulting Editor Frontiers in Genetics and Genomics - - -
Offices Held
Date Office Name Institution Country 2018 - ongoing Australian Epigenetic Alliance- South Australian Representative Australian Epigenetic Alliance (AEpiA) Australia 2016 - 2017 Deputy Head of the Department of Genetics and Evolution School of Biological Sciences, The University of Adelaide Australia 2015 - ongoing GSA South Australian Representative on Executive Genetics Society of AustralAsia Australia
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