Helen Palethorpe

Dr Helen Palethorpe

Research Assistant

Adelaide Medical School

Faculty of Health and Medical Sciences

Helen Palethorpe
Position: Research Assistant.
Group: Colorectal Cancer Research Group, Surgical Science Research Group.
Theme: Cancer, Clinical Sciences, Health Services & Population Health.

About

Helen started working in the Colorectal Cancer Research Group in 2017.

Helen commenced her PhD in 2013 in the Surgical Sciences Research Group under the supervision of Dr Paul Drew and Dr Eric Smith. Her studies were supported by a scholarship from the Faculty of Health Sciences, University of Adelaide. Her thesis title was “Fibroblasts, androgen signalling and oesophageal adenocarcinoma”.

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  • Journals
    Year Citation
    2019 Tomita, Y., Palethorpe, H. M., Smith, E., Nakhjavani, M., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2019). Bumetanide-Derived Aquaporin 1 Inhibitors, AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration In Vitro.. International journal of molecular sciences, 20(8), 11 pages.
    DOI
    2019 Nakhjavani, M., Hardingham, J. E., Palethorpe, H. M., Tomita, Y., Smith, E., Price, T. J., & Townsend, A. R. (2019). Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.. Medicines (Basel, Switzerland), 6(1), 20 pages.
    DOI
    2019 Smith, E., Tomita, Y., Palethorpe, H. M., Howell, S., Nakhjavani, M., Townsend, A. R., . . . Hardingham, J. E. (2019). Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation. Epigenetics, 14(2), 158-170.
    DOI
    2018 Palethorpe, H., Tomita, Y., Smith, E., Pei, J., Townsend, A., Price, T., . . . Hardingham, J. (2018). The aquaporin 1 inhibitor bacopaside II reduces endothelial cell migration and tubulogenesis and induces apoptosis. International Journal of Molecular Sciences, 19(3), 653-1-653-10.
    DOI Scopus1 WoS2 Europe PMC2
    2018 Palethorpe, H., Leach, D., Need, E., Drew, P., & Smith, E. (2018). Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro. Oncotarget, 9(27), 19100-19114.
    DOI Scopus1 Europe PMC1
    2018 Smith, E., Palethorpe, H. M., Tomita, Y., Pei, J., Townsend, A. R., Price, T. J., . . . Hardingham, J. E. (2018). The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis. CELLS, 7(7), 11 pages.
    DOI WoS4 Europe PMC1
    2017 Smith, E., Palethorpe, H., Hayden, A., Young, J., Underwood, T., & Drew, P. (2017). Fibroblasts derived from oesophageal adenocarcinoma differ in DNA methylation profile from normal oesophageal fibroblasts. Scientific Reports, 7(1), 3368-1-3368-9.
    DOI Scopus1 WoS1
    2017 Palethorpe, H., Drew, P., & Smith, E. (2017). Androgen signaling in esophageal adenocarcinoma cell lines in vitro. Digestive Diseases and Sciences, 62(12), 3402-3414.
    DOI Scopus1 WoS4 Europe PMC3
    2016 Smith, E., Palethorpe, H., Ruszkiewicz, A., Edwards, S., Leach, D., Underwood, T., . . . Drew, P. (2016). Androgen receptor and androgen-responsive gene FKBP5 are independent prognostic indicators for esophageal adenocarcinoma. Digestive Diseases and Sciences, 61(2), 433-443.
    DOI Scopus6 WoS5 Europe PMC6
    2015 Leach, D., Need, E., Toivanen, R., Trotta, A., Palenthorpe, H., Tamblyn, D., . . . Buchanan, G. (2015). Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome [Oncotarget. 2015; 6:16135-16150]. Oncotarget, 6(34), 36923.
    DOI Scopus1 WoS1 Europe PMC1
    2015 Leach, D., Need, E., Toivanen, R., Trotta, A., Palenthorpe, H., Tamblyn, D., . . . Buchanan, G. (2015). Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome. Oncotarget, 6(18), 16135-16150.
    DOI Scopus28 WoS27 Europe PMC24
    2003 Butcher, A., Palethorpe, H., & Grove, D. (2003). Response to re-infection with Brachylaima cribbi in immunocompetent and immunodeficient mice. PARASITOLOGY INTERNATIONAL, 52(3), 219-228.
    DOI WoS5 Europe PMC2
    2002 Butcher, A. R., Palethorpe, H. M., & Grove, D. I. (2002). The susceptibility of inbred mice to infection with Brachylaima cribbi (Digenea: Brachylaimidae).. Parasitology international, 51(1), 109-115.
    DOI Europe PMC5
    2002 Butcher, A., Palethorpe, H., & Grove, D. (2002). Effects of sex and age on the susceptibility of C57BL/6J mice to infection with Brachylaima cribbi and the course of infection in NOD SCID mice. PARASITOLOGY RESEARCH, 88(7), 668-674.
    DOI WoS11 Europe PMC7

  • Conference Items
    Year Citation
    2019 Smith, E., Tomita, Y., Palethorpe, H., Howell, S., Nakhjavani, M., Townsend, A., . . . Hardingham, J. (2019). Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation and improved overall survival. Poster session presented at the meeting of 31st Lorne Cancer Conference. Lorne, VIC, Australia.
    2018 Palethorpe, H. M., Tomita, Y., Smith, E., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Bacopaside II reduces endothelial cell migration and angiogenesis in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne.
    2018 Smith, E., Palethorpe, H. M., Tomita, Y., Townsend, A. R., Price, T. J., Yool, A. J., & Hardingham, J. E. (2018). Anti-tumour effects of Bacopaside II on colorectal cancer cells in vitro. Poster session presented at the meeting of 30th Lorne Cancer Conference. Lorne, VIC.
    2017 Palethorpe, H. M., Smith, E., & Drew, P. A. (2017). New roles for myofibroblasts in cancer - insights from two cancers. Poster session presented at the meeting of The Queen Elizabeth Hospital Research Day.
    2016 Palethorpe, H. M., Smith, E., & Drew, P. A. (2016). The effect of fibroblasts on androgen signalling in oesophageal adenocarcinoma cell lines in vitro. Poster session presented at the meeting of The Queen Elizabeth Hospital Research Day.
    2016 Palethorpe, H. M., Smith, E., & Drew, P. A. (2016). The effect of fibroblasts on androgen signalling in oesophageal adenocarcinoma cell lines in vitro. Poster session presented at the meeting of 10th Florey International Postgraduate Research Conference. The University of Adelaide.
    2015 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2015). Myofibroblast androgen receptor expression modifies direct and indirect interactions between myofibroblasts and prostate cancer cells in vitro. Poster session presented at the meeting of 9th Florey International Postgraduate Research Conference 2015. Adelaide SA.
    2015 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2015). Myofiboblast androgen receptor expression modifies direct and indirect interactions between myofibroblasts and prostate cancer cells in vitro. Poster session presented at the meeting of South Australian Men’s Health Research Symposium. South Australian Health and Medical Research Institute (SAHMRI), Adelaide SA.
    2015 Smith, E., Palethorpe, H., Ruszkiewicz, A., Edwards, S., Leach, D., Underwood, T., . . . Drew, P. (2015). Expression of androgen receptor and the androgen-responsive gene FKBP5 are independent prognostic indicators for oesophageal adenocarcinoma. Poster session presented at the meeting of Abstracts of the South Australian Men’s Health Research Symposium. South Australian Health and Medical Research Institute (SAHMRI), Adelaide SA: The University of Adelaide.
    2015 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2015). Myofiboblast androgen receptor expression modifies indirect and direct interactions between myofibroblasts and prostate cancer cells in vitro. Poster session presented at the meeting of ASMR SA Annual Scientific Meeting. Adelaide SA.
    2014 Smith, E., Palethorpe, H. M., Ruszkiewicz, A. R., Leach, D. A., Need, E. F., & Drew, P. A. (2014). Expression of androgen receptor and the androgen receptor responsive gene FKBP5 in oesophageal adenocarcinoma. Poster session presented at the meeting of 7th Australian Health & Medical Research Congress 2014. Melbourne Convention and Exhibition Centre, Melbourne, Victoria.
    2014 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2014). Myofibroblast androgen receptor expression regulates direct and indirect interactions between myofibroblast and prostate cancer cells in vitro. Poster session presented at the meeting of The Queen Elizabeth Hospital Research Day 2014. Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, SA.
    2014 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2014). Myofibroblast androgen receptor expression regulates direct and indirect interactions between myofibroblast and prostate cancer cells in vitro. Poster session presented at the meeting of Florey International Postgraduate Research Conference 2014.
    2014 Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2014). The effect of androgen receptor expression in fibroblasts co-cultured with prostate cancer cells. Poster session presented at the meeting of ASMR SA Annual Scientific Meeting. Adelaide SA.
  • Position: Research Assistant
  • Phone: 82227180
  • Email: helen.palethorpe@adelaide.edu.au
  • Campus: North Terrace
  • Building: TQEH - Basil Hetzel Institute, floor 1
  • Org Unit: Adelaide Medical School
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