Dr Hannah Brown

Hannah Brown
Postdoctoral Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences

Dr. Hannah Brown is a Robinson Research Institute Postdoctoral Fellow and is under the mentorship of Associate Professor Jeremy Thompson and Professor Sarah Robertson. She gained her PhD from the University of Adelaide and took up international postdoctoral posts in both France (INRA) and the United States (Baylor College of Medicine). Her interests lay in the fields of epigenetics and metabolism, and in particular the changing epigenetic landscape of the early embryo. She is particularly interested in how the embryo responds to physiological and pathological environmental cues, including in vitro culture, hyperglycaemia (diabetes) and inflammation (infection). Understanding the molecular mechanisms by which these cues are translated into an altered epigenetic backdrop is the key question her growing team are addressing. She is passionate about science communication and is currently a SA Young Tall Poppy.

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Dr Hannah Brown

Dr. Hannah Brown is a Robinson Research Institute Postdoctoral Fellow and is under the mentorship of Associate Professor Jeremy Thompson and Professor Sarah Robertson. She gained her PhD from the University of Adelaide and took up international postdoctoral posts in both France (INRA) and the United States (Baylor College of Medicine). Her interests lay in the fields of epigenetics and metabolism, and in particular the changing epigenetic landscape of the early embryo. She is particularly interested in how the embryo responds to physiological and pathological environmental cues, including in vitro culture, hyperglycaemia (diabetes) and inflammation (infection). Understanding the molecular mechanisms by which these cues are translated into an altered epigenetic backdrop is the key question her growing team are addressing. She is passionate about science communication and is currently a SA Young Tall Poppy.

Dr Hannah Brown is an early career researcher establishing herself in the field of reproductive metabolism, oxygen biology and epigenetics following two international postdoctoral posts.  During two international post-doctoral positions, she honed her skills in the fields of metabolism and genetics/genomics and is establishing herself in the Reproductive Epigenetics field since returning to Australia.  Her research focuses on mechanisms by which the pre-implantation embryo alters its internal dialogue in response to environmental changes (diabetes, infection, culture, oxygen), altering the transcriptional and epigenetic landscapes to establish the trajectory of the embryo, and the resultant offspring.  This research provides critical understanding into the mechanisms for the intergenerational transmission of disease (diabetes and obesity), and has direct implications for understanding the stress associated with generating embryos in vitro, as well as for providing the basis for emerging developments to assisted reproductive technologies (in vitro culture, oxygen, haemoglobin). 

Appointments

Date Position Institution name
2012 Postdoctoral Fellow University of Adelaide
2010 - 2012 Postdoctoral Associate Baylor College of Medicine
2009 - 2010 Postdoctoral Associate Postdoctoral Associate, L’Institut National de la Recherché Agronomique (INRA)

Awards and Achievements

Date Type Title Institution Name Amount
2016 Invitation Global Young Scientist Summit National Research Foundation
2015 Award South Australian Young Investigator Award (People’s Choice) Women's and Children's Hospital 1000
2015 Award ECR Collaborative Travel Award Society for Reproductive Biology 1500
2015 Award Executive Dean's ECR Research Excellence Award University of Adelaide Faculty of Health Sciences 1000
2015 Award South Australian Young Investigator Award Women's and Children's Hospital 5000
2014 Recognition South Australia Young Tall Poppy Australian Institute of Policy and Science
2012 Award I’m A Scientist! Get me out of here, Australia 1000

Education

Date Institution name Country Title
2005 - 2009 University of Adelaide, Discipline of Medicine Australia Docor of Philosophy
2004 - 2004 University of Adelaide Australia Bachelor of Science, Honours (First Class; 1A)
2001 - 2003 University of Adelaide Australia Bachelor of Science (Biomedical Science)

Journals

Year Citation
2017 Brown, H., Dunning, K., Sutton-McDowall, M., Gilchrist, R., Thompson, J. & Russell, D. (2017). Failure to launch: aberrant cumulus gene expression during oocyte in vitro maturation. Reproduction, 153, 3, R109-R120.
10.1530/REP-16-0426
2017 Akison, L., Andraweera, P., Bertoldo, M., Brown, H., Cuffe, J., Fullston, T. ... Schjenken, J. (2017). The current state of reproductive biology research in Australia and New Zealand: core themes from the Society for Reproductive Biology Annual Meeting, 2016. Reproduction, Fertility and Development, 29, 10, 1883-1889.
10.1071/RD16382
2017 Brown, H., Cruz, M. & Mol, B. (2017). Social media is essential for research engagement: FOR: Facilitating stakeholder engagement is key!. BJOG: An International Journal of Obstetrics and Gynaecology, 124, 6, 902-.
10.1111/1471-0528.14531
2016 Ross, M. D., Dunning, K. R., Ritter, L. A., Thompson, J. G. & Brown, H. M. (2016). Insulin impacts cumulus oocyte complex maturation and early embryo development in vitro. CLINICAL ENDOCRINOLOGY, 84, 48-48.
2016 Thompson, J., Brown, H. & Sutton-McDowall, M. (2016). Measuring embryo metabolism to predict embryo quality. Reproduction Fertility and Development, 28, 2, 41-50.
10.1071/RD15340
2016 Russell, D., Gilchrist, R., Brown, H. & Thompson, J. (2016). Bidirectional communication between cumulus cells and the oocyte: old hands and new players?. Theriogenology, 86, 1, 62-68.
10.1016/j.theriogenology.2016.04.019
2016 Tan, T., Ritter, L., Whitty, A., Fernandez, R., Moran, L., Robertson, S. ... Brown, H. (2016). Gray level co-occurrence matrices (GLCM) to assess microstructural and textural changes in pre-implantation embryos. Molecular Reproduction and Development, 83, 8, 701-713.
10.1002/mrd.22680
2016 Moran, L., Spencer, L., Russell, D., Hull, M., Robertson, S., Varcoe, T. ... Rodgers, R. (2016). Research priorities for fertility and conception research as identified by multidisciplinary health care practitioners and researchers. Nutrients, 8, 1, 35-1-35-8.
10.3390/nu8010035
2016 Kyle, S., Saha, P., Brown, H., Chan, L. & Justice, M. (2016). MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Human Molecular Genetics, 25, 14, 3029-3041.
10.1093/hmg/ddw156
2016 Fernandez, R., Marino, J., Varcoe, T., Davis, S., Moran, L., Rumbold, A. ... Moore, V. (2016). Fixed or rotating night shift work undertaken by women: implications for fertility and miscarriage. Seminars in Reproductive Medicine, 34, 2, 74-82.
10.1055/s-0036-1571354
2015 Thompson, J., Brown, H., Kind, K. & Russell, D. (2015). The ovarian antral follicle: living on the edge of hypoxia or not?. Biology of Reproduction, 92, 6, 153-1-153-6.
10.1095/biolreprod.115.128660
2015 Kind, K., Tam, K., Banwell, K., Gauld, A., Russell, D., Macpherson, A. ... Thompson, J. (2015). Oxygen-regulated gene expression in murine cumulus cells. Reproduction, Fertility and Development, 27, 2, 407-418.
10.1071/RD13249
2015 Dunning, K., Watson, L., Zhang, V., Brown, H., Kaczmarek, A., Robker, R. & Russell, D. (2015). Activation of mouse cumulus-oocyte complex maturation in vitro through EGF-like activity of versican. Biology of Reproduction, 92, 5, 116-1-116-10.
10.1095/biolreprod.114.127274
2015 Russell, D., Brown, H. & Dunning, K. (2015). ADAMTS proteases in fertility. Matrix Biology, 44-46, 54-63.
10.1016/j.matbio.2015.03.007
2015 Sutton-McDowall, M., Purdey, M., Brown, H., Abell, A., Mottershead, D., Cetica, P. ... Thompson, J. (2015). Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Molecular Reproduction and Development, 82, 4, 281-294.
10.1002/mrd.22470
2015 Brown, H., Anastasi, M., Frank, L., Kind, K., Richani, D., Robker, R. ... Thompson, J. (2015). Hemoglobin: a gas transport molecule that is hormonally regulated in the ovarian follicle in mice and humans. Biology of reproduction, 92, 1, 26-1-26-10.
10.1095/biolreprod.114.124594
2014 Scaramuzzi, R. J., Oujagir, L., Menassol, J. B., Freret, S., Piezel, A., Brown, H. M. ... Fabre Nys, C. (2014). The pattern of LH secretion and the ovarian response to the ‘ram effect’ in the anoestrous ewe is influenced by body condition but not by short-term nutritional supplementation. Reproduction, Fertility and Development, 26, 8, 1154-1165.
10.1071/RD13139
2014 Sen, P., Dharmadhikari, A., Majewski, T., Mohammad, M., Kalin, T., Zabielska, J. ... Stankiewicz, P. (2014). Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice. M. Koval (Ed.). PLoS One, 9, 4, e94390-1-e94390-10.
10.1371/journal.pone.0094390
2014 Brown, H. & Russell, D. (2014). Blood and lymphatic vasculature in the ovary: development, function and disease. Human Reproduction Update, 20, 1, 29-39.
10.1093/humupd/dmt049
2014 Brown, H., Fabre Nys, C., Cognié, J. & Scaramuzzi, R. (2014). Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation. Reproduction, 147, 3, 357-367.
10.1530/REP-13-0400
2014 Frank, L., Sutton-McDowall, M., Brown, H., Russell, D., Gilchrist, R. & Thompson, J. (2014). Hyperglycaemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of Heat shock protein 90. Human Reproduction, 29, 6, 1292-1303.
10.1093/humrep/deu066
2013 Buchovecky, C., Turley, S., Brown, H., Kyle, S., McDonald, J., Liu, B. ... Justice, M. (2013). A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nature Genetics, 45, 9, 1013-1022.
10.1038/ng.2714
2013 Care, A., Diener, K., Jasper, M., Brown, H., Ingman, W. & Robertson, S. (2013). Macrophages regulate corpus luteum development during embryo implantation in mice. Journal of Clinical Investigation, 123, 8, 3472-3487.
10.1172/JCI60561
2012 Dunning, K., Watson, L., Sharkey, D., Brown, H., Norman, R., Thompson, J. ... Russell, D. (2012). Molecular filtration properties of the mouse expanded cumulus matrix: controlled supply of metabolites and extracellular signals to cumulus cells and the oocyte. Biology of Reproduction, 87, 4, 1-10.
10.1095/biolreprod.111.096271
2011 Johnson, L., Fabre Nys, C., Chanvallon, A., François, D., Fassier, T., Menassol, J. B. ... Scaramuzzi, R. J. (2011). The effect of short-term nutritional supplementation and body condition on the pituitary and ovarian responses of anoestrous ewes to the “ram effect”. Journal of Veterinary Science & Technology, S2, 001, 1-10.
10.4172/2157-7579.S2-001
2010 Brown, H., Robker, R. & Russell, D. (2010). Development and hormonal regulation of the ovarian lymphatic vasculature. Endocrinology, 151, 11, 5446-5455.
10.1210/en.2010-0629
2010 Scaramuzzi, R., Brown, H. & Dupont, J. (2010). Nutritional and Metabolic Mechanisms in the Ovary and Their Role in Mediating the Effects of Diet on Folliculogenesis: A Perspective. Reproduction in Domestic Animals, 45, 32-41.
10.1111/j.1439-0531.2010.01662.x
2010 Brown, H., Dunning, K., Robker, R., Boerboom, D., Pritchard, M., Lane, M. & Russell, D. (2010). ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice. Biology of Reproduction, 83, 4, 549-557.
10.1095/biolreprod.110.084434
2010 Everaert, N., Willemsen, H., Hulikova, A., Brown, H., Decuypere, E., Swietach, P. & Bruggeman, V. (2010). The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2. Respiratory Physiology & Neurobiology, 172, 3, 154-161.
10.1016/j.resp.2010.05.007
2007 Dunning, K., Lane, M., Brown, H., Yeo, C., Robker, R. & Russell, D. (2007). Altered composition of the cumulus-oocyte complex matrix during in vitro maturation of oocytes. Human Reproduction, 22, 11, 2842-2850.
10.1093/humrep/dem277
2006 Brown, H., Dunning, K., Robker, R., Pritchard, M. & Russell, D. (2006). Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Developmental Biology, 300, 2, 699-709.
10.1016/j.ydbio.2006.10.012
2005 Brown, H., Pritchard, M. & Russell, D. (2005). Early ovarian follicle dysgenesis in a disintegrin and metalloproteinase with thrombospondin motifs type 1 (ADAMTS-1) null mice. Reproduction Fertility and Development, 17, 9, 87-87.
10.1071/SRB05Abs225

Conference Papers

Year Citation
2015 Brown, H., Tan, T. & Thompson, J. (2015). Metaboloepigenetics: providing alternative hypotheses for regulation of gene expression in the early embryo. 29th Annual Meeting of the Brazilian Embryo Technology Society (SBTE). Rio Grande do Sul, Brazil.
2008 Russell, D., Brown, H., Alvino, E. & Robker, R. (2008). Involvement of blood and lymphatic angiogenesis in folliculogenesis and ovulation. 41st Annual Meeting of the Society-for-the-Study-of-Reproduction. Kona, HI.
10.1093/biolreprod/78.s1.79b
2006 Russell, D. L., Brown, H. M., Dunning, K. R., Pritchard, M. A. & Robker, R. L. (2006). Ovarian folliculogenesis and lymphangiogenesis are dependent on ECM remodelling by the protease ADAMTS-1.. 39th Annual Meeting of the Society-for-the-Study-of-Reproduction. Univ Nebraska Med Ctr, Omaha, NE.

Conference Items

Year Citation
2014 Brown, H., Frank, L. & Thompson, J. (2014). Hyperglycaemia: A new player in oocyte epigenetics. 4th Mammalian Embryo Genomics Meeting. Quebec, CANADA.
10.1016/j.anireprosci.2014.06.017
Date Project/ No. Investigators Funding Body Amount
2016 How periconception hyperglycaemia disturbs early life events Brown HM and Thompson JG Robinson Research Institute Investment for Success 17,000
2015 Inflammatory cytokines as causal agents in peri-conception programming of offspring health Robertson SA, Thompson JG and Brown HM NHMRC Project Grant 585,000
2015 A multi-faceted approach to understanding the consequences of diabetes in early pregnancy Brown HM, Breen J, Nottle M, Dunning KR, Gatford KA Robinson Research Institute Innovation Seed Funding 25,000
2015 Do psychosocial attributes and lifestyle behaviors moderate associations of job-related stress and cardiometabolic risk factors among residents of South Australian farming communities Dollman J, Smith A, Parfitt G, Fennell K, Dorian J, van Kessel G, Wheeler S, Turnbull D, Brown H, McDougall C Sansom Institute, UNISA 10,000
2015 Concurrent validity and feasibility of ecological momentary assessment for characterising stress and depression among South Australian farmers Dollman J, Smith A, Parfitt G, Wheeler S, Turnbull D, Brown H, McDougall C Sansom Institute, UNISA 9,000
2014 Investigating new mechanisms regulating transcription in the pre-implantation embryo Buckberry S, Searle I, Bent S, Thompson JG Robinson Research Institute Innovation Seed Funding 25,000
2014 Novel mechanisms regulating placental dysfunction in pre-eclampsia Andraweera P, Brown HM, Roberts C, Buckberry S Robinson Research Institute Innovation Seed Funding 25,000
2014 Novel mechanisms regulating intergenerational transmission of diabetes Brown HM and Thompson JG Robinson Research Institute Investment for Success 30,000
2014   Brown HM Robinson Research Institute Career Development Award 50,000
2011 Evaluating metabolic and endocrine abnormalities in Rett Syndrome: Neurology meets systems physiology Brown HM and Justice MJ Rett Syndrome Research Trust (RSRT) 15,000
Date Role Course
2014 - current  Lecturer

Research Project in Reproduction III (Health Sciences)

2014 - current  Lecturer

School of Paediatrics and Reproductive Health Hons (Health Sciences)

2011 - 2012 Lecturer Genetics; 1st and 2nd Year Medical Course, BCM, USA

 

 PhD Students

Date Name Role
2016 - present Megan Lim Co-supervisor
2016-present Thao (Doan) Dinh Co-supervisor
2016 - present Avi Saini Co-supervisor
2015 - present Shaz Abdulrahman Co-supervisor
2014 - present Ryan Rose Co-supervisor

 Masters Students

Date Name Role
2016 - present Lakshmi Chandrapaty Co-supervisor

Honours Student

Date Name Role
2016 Sophie Kenzior Primary Supervisor
2016 Joseph Femia Primary Supervisor
2015 Emma Tregoweth Primary Supervisor
2015 Mitchell Ross Primary Supervisor
2015 Thao Doan Co-supervisor
2015 Megan Lim Co-supervisor
2015 Alexandra Samantha Co-supervisor
2014 - 2015 Tiffany Tan Primary Supervisor

 Various Supervision

Date Name Program Role
2016 Freya Proeve                                                          Bachelor Health Science Advanced (3rd Year) Supervisor
2016 Vidhiya Somasundaram Bachelor Health Science Advanced (3rd Year) Supervisor
2016 Anmol Saini Research Project in Reproduction (3rd Year) Supervisor
2016 Darren Chow Research Project in Reproduction (3rd Year) Supervisor
2015 - 2016 Anmol Saini Summer student Supervisor
2015 - 2016 Darren Chow Summer student Supervisor
2015 - 2016 Sophie Kedzior Summer student Supervisor
2015 - 2016 Edward Gore Summer student Supervisor
2015 Masuma Bashiri Research Project in Reproduction (3rd Year) Supervisor
2015 Thira Rattanakosit Research Project in Reproduction (3rd Year) Supervisor
2015 Oscar Yarankunze Research Project in Reproduction (3rd Year) Supervisor
2013 - 2014 Karagh Lioing Summer student Supervisor

 

Mentoring

Date Name Program Role
2016 Mark Limongelli Bachelor Health Science Advanced Mentor
2016 Sean Mangion Bachelor Health Science Advanced Mentor
2015 Edward Gore Bachelor Health Science Advanced Mentor
2015 Mark Limongelli Bachelor Health Science Advanced Mentor

 

Committee Memberships

Date Role Committee Institution Country
2016 - ongoing Chair School of Medicine Early/Mid-Career Researcher Committee University of Adelaide Australia
2016 - ongoing Member School of Medicine Research Committee University of Adelaide Australia
2015 - ongoing Chair Epigenetics Consortium of South Australia (EpiCSA) Inc Australia
2015 - ongoing Member Society for Reproductive Biology Australia
2014 - ongoing Member NHMRC Australia
2014 - ongoing Member New Frontiers in Reproduction Conference
2014 - ongoing Representative Society for the Study of Reproduction United States
2014 - ongoing Member Discipline of Obstetrics & Gynaecology Honours Committee University of Adelaide Australia
2013 - ongoing Member Young Investigator Award Women's & children's Hospital Australia
2013 - ongoing Representative School of Paediatrics & Reproductive Health University of Adelaide Australia
2013 - 2015 Member School of Pediatrics & Reproductive Health Research Committee University of Adelaide Australia
Position
Postdoctoral Fellow
Phone
83138183
Fax
8313 4099
Campus
North Terrace
Building
Medical School South
Room Number
2 22
Org Unit
Paediatrics and Reproductive Health

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