Adelaide Medical School
Faculty of Health and Medical Sciences
Dr. Hannah Brown is a Robinson Research Institute Postdoctoral Fellow and is under the mentorship of Associate Professor Jeremy Thompson and Professor Sarah Robertson. She gained her PhD from the University of Adelaide and took up international postdoctoral posts in both France (INRA) and the United States (Baylor College of Medicine). Her interests lay in the fields of epigenetics and metabolism, and in particular the changing epigenetic landscape of the early embryo. She is particularly interested in how the embryo responds to physiological and pathological environmental cues, including in vitro culture, hyperglycaemia (diabetes) and inflammation (infection). Understanding the molecular mechanisms by which these cues are translated into an altered epigenetic backdrop is the key question her growing team are addressing. She is passionate about science communication and is currently a SA Young Tall Poppy.
- My Research
- Grants and Funding
- Professional Activities
Dr Hannah Brown is an early career researcher establishing herself in the field of reproductive metabolism, oxygen biology and epigenetics following two international postdoctoral posts. During two international post-doctoral positions, she honed her skills in the fields of metabolism and genetics/genomics and is establishing herself in the Reproductive Epigenetics field since returning to Australia. Her research focuses on mechanisms by which the pre-implantation embryo alters its internal dialogue in response to environmental changes (diabetes, infection, culture, oxygen), altering the transcriptional and epigenetic landscapes to establish the trajectory of the embryo, and the resultant offspring. This research provides critical understanding into the mechanisms for the intergenerational transmission of disease (diabetes and obesity), and has direct implications for understanding the stress associated with generating embryos in vitro, as well as for providing the basis for emerging developments to assisted reproductive technologies (in vitro culture, oxygen, haemoglobin).
Date Position Institution name 2012 Postdoctoral Fellow University of Adelaide 2010 - 2012 Postdoctoral Associate Baylor College of Medicine 2009 - 2010 Postdoctoral Associate Postdoctoral Associate, L’Institut National de la Recherché Agronomique (INRA)
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Invitation Global Young Scientist Summit National Research Foundation Singapore — 2015 Award Executive Dean's ECR Research Excellence Award University of Adelaide Faculty of Health Sciences Australia 1000 2015 Award South Australian Young Investigator Award Women's and Children's Hospital — 5000 2015 Award South Australian Young Investigator Award (People’s Choice) Women's and Children's Hospital Australia 1000 2015 Award ECR Collaborative Travel Award Society for Reproductive Biology Australia 1500 2014 Recognition South Australia Young Tall Poppy Australian Institute of Policy and Science Australia — 2012 Award I’m A Scientist! Get me out of here, Australia — Australia 1000
Date Institution name Country Title 2005 - 2009 University of Adelaide, Discipline of Medicine Australia Docor of Philosophy 2004 - 2004 University of Adelaide Australia Bachelor of Science, Honours (First Class; 1A) 2001 - 2003 University of Adelaide Australia Bachelor of Science (Biomedical Science)
Year Citation 2017 Orth, A., Doughney, T., Reineck, P., Brown, H., Thompson, J., & Gibson, B. (2017). Bleaching-assisted multichannel microscopy. In Optics InfoBase Conference Papers Vol. Part F63-OMP 2017 (pp. 1-3). online: OSA Publishing.
2015 Brown, H., Tan, T., & Thompson, J. (2015). Metaboloepigenetics: providing alternative hypotheses for regulation of gene expression in the early embryo. In Animal Reproduction Vol. 12 (pp. 437-443). Brazil: Brazilian College of Animal Reproduction.
2008 Russell, D., Brown, H., Alvino, E., & Robker, R. (2008). Involvement of blood and lymphatic angiogenesis in folliculogenesis and ovulation. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 79). Kona, HI: SOC STUDY REPRODUCTION.
2006 Russell, D. L., Brown, H. M., Dunning, K. R., Pritchard, M. A., & Robker, R. L. (2006). Ovarian folliculogenesis and lymphangiogenesis are dependent on ECM remodelling by the protease ADAMTS-1.. In BIOLOGY OF REPRODUCTION (pp. 109). Univ Nebraska Med Ctr, Omaha, NE: SOC STUDY REPRODUCTION.
Year Citation 2014 Brown, H., Frank, L., & Thompson, J. (2014). Hyperglycaemia: A new player in oocyte epigenetics. Poster session presented at the meeting of ANIMAL REPRODUCTION SCIENCE. Quebec, CANADA: ELSEVIER SCIENCE BV.
|Date||Project/ No.||Investigators||Funding Body||Amount|
|2016||How periconception hyperglycaemia disturbs early life events||Brown HM and Thompson JG||Robinson Research Institute Investment for Success||17,000|
|2015||Inflammatory cytokines as causal agents in peri-conception programming of offspring health||Robertson SA, Thompson JG and Brown HM||NHMRC Project Grant||585,000|
|2015||A multi-faceted approach to understanding the consequences of diabetes in early pregnancy||Brown HM, Breen J, Nottle M, Dunning KR, Gatford KA||Robinson Research Institute Innovation Seed Funding||25,000|
|2015||Do psychosocial attributes and lifestyle behaviors moderate associations of job-related stress and cardiometabolic risk factors among residents of South Australian farming communities||Dollman J, Smith A, Parfitt G, Fennell K, Dorian J, van Kessel G, Wheeler S, Turnbull D, Brown H, McDougall C||Sansom Institute, UNISA||10,000|
|2015||Concurrent validity and feasibility of ecological momentary assessment for characterising stress and depression among South Australian farmers||Dollman J, Smith A, Parfitt G, Wheeler S, Turnbull D, Brown H, McDougall C||Sansom Institute, UNISA||9,000|
|2014||Investigating new mechanisms regulating transcription in the pre-implantation embryo||Buckberry S, Searle I, Bent S, Thompson JG||Robinson Research Institute Innovation Seed Funding||25,000|
|2014||Novel mechanisms regulating placental dysfunction in pre-eclampsia||Andraweera P, Brown HM, Roberts C, Buckberry S||Robinson Research Institute Innovation Seed Funding||25,000|
|2014||Novel mechanisms regulating intergenerational transmission of diabetes||Brown HM and Thompson JG||Robinson Research Institute Investment for Success||30,000|
|2014||Brown HM||Robinson Research Institute Career Development Award||50,000|
|2011||Evaluating metabolic and endocrine abnormalities in Rett Syndrome: Neurology meets systems physiology||Brown HM and Justice MJ||Rett Syndrome Research Trust (RSRT)||15,000|
|2014 - current||Lecturer||
Research Project in Reproduction III (Health Sciences)
|2014 - current||Lecturer||
School of Paediatrics and Reproductive Health Hons (Health Sciences)
|2011 - 2012||Lecturer||Genetics; 1st and 2nd Year Medical Course, BCM, USA|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 Co-Supervisor Can hyperspectral microscopy detect metabolic variance in the oocyte and pre-implantation embryo? Doctor of Philosophy Doctorate Full Time Miss Cheow Yuen Tan 2016 Co-Supervisor Non-reproductive uses of Zonae Pellucida Master of Philosophy (Medical Science) Master Full Time Avishkar Saini
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 - 2020 Co-Supervisor The Role of Haemoglobin in Healthy Oocyte Development Doctor of Philosophy Doctorate Full Time Ms Megan Lim 2015 - 2017 Co-Supervisor Novel Functions of Natriuretic Peptides in Mammalian Cumulus-Oocyte Complexes Doctor of Philosophy Doctorate Part Time Mr Ryan David Rose
Date Role Committee Institution Country 2017 - 2019 Chair Organising Committee Epigenetics Consortium of South Australia (EpiCSA) Inc Australia 2016 - ongoing Chair School of Medicine Early/Mid-Career Researcher Committee University of Adelaide Australia 2016 - ongoing Member School of Medicine Research Committee University of Adelaide Australia 2015 - ongoing Member Society for Reproductive Biology — Australia 2014 - ongoing Member Discipline of Obstetrics & Gynaecology Honours Committee University of Adelaide Australia 2014 - ongoing Representative Society for the Study of Reproduction — United States 2014 - ongoing Member NHMRC — Australia 2014 - ongoing Member New Frontiers in Reproduction Conference — — 2013 - 2015 Member School of Pediatrics & Reproductive Health Research Committee University of Adelaide Australia 2013 - ongoing Representative School of Paediatrics & Reproductive Health University of Adelaide Australia 2013 - ongoing Member Young Investigator Award Women's & children's Hospital Australia
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