Hamish Scott

Professor Hamish Scott

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Professor Hamish Scott - TITLEHOLDER.
Professor Scott completed his PhD in1992. His first post-doc position was at the Women’s and Children’s Hospital and the University of Adelaide. During these 7 years he led the discovery of genes for 3 rare human diseases. After 11 more years this resulted in either FDA approved therapy (2003) or clinical trials of novel therapies for these diseases.
In 1995, Hamish moved to the University of Geneva Medical School in Switzerland. His focus was, and remains, the application of genetic and genomic technologies to understand diseases processes to improve diagnoses and treatment. He led international collaborations in identification of human genes causing Down syndrome and rare forms of genetic deafness and autoimmunity (e.g. arthritis and multiple sclerosis). This continues to have profound effects on our understanding of basic biology of Down syndrome, hearing and the immune system and lead to new therapeutic strategies in these and related diseases. This was also the start of his interest in cancer and leukemia as children with Down syndrome have a low incidence of solid tumours and a high incidence of leukemia. This is also when he started to work on familial predisposition to leukemia.

Hamish relocated to the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne in 2000 as the Inaugural Nossal Leadership Fellow. He was appointed as a National Health and Medical Research Council (NHMRC) senior research fellow in 2001. His laboratory identified 2 additional deafness genes and described the role of a gene in reprogramming the DNA of an “adult” cell from “normal” to become a gamete (sperm or oocyte). He also described a cause of familial predisposition to leukemia.

Since returning to Adelaide in January 2008 he has been Deputy and then Head of the Department of Molecular Pathology at SA Pathology, He is an inaugural member of the Centre for Cancer Biology an Affiliate Professor in both the Schools of Medicine and Molecular and Biomedical Science at the University of Adelaide and an Adjunct Professor in the School of Pharmacy and Medical Sciences in the Division of Health Sciences of the University of South Australia. He is an NHMRC principal research fellow, a Founding Fellow of the Faculty of Science (FFSc) of the Royal College of Pathologists of Australasia (RCPA) and was recently (2015) elected as a Fellow to the Australian Academy of Health and Medical Sciences (FAHMS).

He has led recent international collaborations published in Nat Genet and Blood (x2) on identification of germline mutations in rare families and patients that predispose them to acute myeloid leukemia (AML), infectious diseases, lymphoedema (in GATA2 Embergers syndrome and familial MDS/AML) and diverse hematologic malignancies (in DDX41). This has lead international recognition of the fact that there can be a substantive, sometimes monogenic, predisoposition to haematological malignancies and response to treatments.

He is a Joint Director of the CCB ACRF Cancer Genome Facility established at SA Pathology, the Facilitator of the Genomics, Genetics and Drugable Targets pillar, of the South Australian Comprehensive Cancer Consortium, on the Executive Committee of the South Australian Cancer Research Biobank and the National Steering Committee of the newly NHMRC funded Australian Genomics Health Alliance. In these roles he has been central to introducing introduce new technologies for both somatic and germline genotyping (e.g. using next generation sequencing to SA Pathology at a panel, exome and whole genome level) for improved diagnoses and treatment (personalized medicine) for which his team won an SA Health Award for Excellence.

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Principal Supervisor Defining the Role of MDFIC Gene in Cardiovascular Development Master of Clinical Science Master Full Time Ms Saba Montazaribarforoushi
    2016 Co-Supervisor ARMC5 and other genetic contributions in endocrine neoplasia Doctor of Philosophy Doctorate Full Time Sunita Maria De Sousa
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2012 - 2016 Principal Supervisor Identification and Characterisation of Genetic Lesions that Predispose to and Gene Expression Patterns that Contribute to Myeloid Malignancies Doctor of Philosophy Doctorate Full Time Ms Parvathy Venugopal
    2012 - 2016 Co-Supervisor Prognostic Markers Associated With Tyrosine Kinase Inhibitor Treatment Response and Maintenance of Treatment Free Remission in Chronic Myeloid Leukaemia Doctor of Philosophy Doctorate Full Time Dr David Yeung
    2010 - 2014 External Supervisor Identification and Annotation of Recombinant Repeats In Mammals Indicates They Are Experimental Products For Creating Novel Transposable Element Families Doctor of Philosophy Doctorate Full Time Mr Sim Lin Lim
    2009 - 2011 Co-Supervisor Regulation of Cortisol Secretion in Humans; Relation to Vasopressin Action at the Adrenals in Macronodular and Micronodular Adrenocortical Tumours and Well-Being in Addison's Disease Doctor of Philosophy Doctorate Full Time Dr Lucia Gagliardi
    2009 - 2013 Principal Supervisor Genetics and Functional Characterization of GATA2, a Novel Cancer Gene in Familial Leukaemia Doctor of Philosophy Doctorate Full Time Mr Chan Eng Chong
    2008 - 2011 Principal Supervisor Identification and Characterisation of Novel Transcripts Involved in the Proliferation, Differentiation and Development Networks of the Mouse Cerebral Cortex Doctor of Philosophy Doctorate Full Time Mr King Hwa Ling
  • Phone: 82223651
  • Email: hamish.scott@adelaide.edu.au
  • Campus: North Terrace
  • Building: Institute of Medical & Veterinary Science
  • Org Unit: School of Biological Sciences

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