Guangze Yang

School of Chemical Engineering

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Guangze Yang is an NHMRC Emerging Leadership Fellow at the School of Chemical Engineering, The University of Adelaide. His research focuses on the development of nanomaterials for biomedical applications, with a particular emphasis on drug delivery and biomimetic materials. His interdisciplinary work spans nanomedicine, polymer science, and bioinspired materials, integrating fundamental research with translational potential.

Dr Yang has published extensively in peer-reviewed journals, with his work receiving citations that reflect its impact within the field. His research has been supported by competitive funding, including the NHMRC Emerging Leadership Fellowship (2025–2029) for the project Innovative Chemoimmunotherapy for Metastatic Castration-Resistant Prostate Cancer. He is actively involved in collaborations with academic and industry partners and contributes to mentoring students and early-career researchers.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

My research is centred on the design and development of advanced nanomaterials for drug delivery, biomimetic systems, and sustainable technologies. A key focus is the engineering of polymeric and lipid nanoparticles with high drug-loading capacity, targeted delivery, and controlled release properties. I also work on microfluidic-based nanoparticle synthesis and advanced drying techniques to improve stability and scalability.

In addition to drug delivery, my research explores biofunctional materials, including peptides, proteins, and stimuli-responsive systems. I investigate how material properties influence cellular interactions, immune responses, and therapeutic efficacy. My work extends to the development of biomolecules for mineral processing, contributing to environmentally sustainable approaches in resource industries.

Through my NHMRC Fellowship, I am investigating novel chemoimmunotherapy strategies for cancer therapy, focusing on nanoparticle-based immunomodulators to enhance treatment effectiveness while minimising side effects. My broader research interests involve bridging fundamental nanomaterial science with practical applications, contributing to advancements in healthcare and industrial biotechnology.

Appointments

Date	Position	Institution name
2025 - 2029	NHMRC Emerging Leadership Fellowship	University of Adelaide
2022 - 2024	Postdoctoral research fellow	University of Adelaide
2020 - 2022	Postdoctoral research fellow	University of Queensland

Awards and Achievements

Date Type Title Institution Name Country Amount

2024 Recognition Top Scholar (Drug Delivery) - Prior 5 Years ScholarGPS United States -
Language Competencies

Language Competency

Chinese (Mandarin) Can read, write, speak, understand spoken and peer review

English Can read, write, speak, understand spoken and peer review

Date	Type	Title	Institution Name	Country	Amount
2024	Recognition	Top Scholar (Drug Delivery) - Prior 5 Years	ScholarGPS	United States	-

Language	Competency
Chinese (Mandarin)	Can read, write, speak, understand spoken and peer review
English	Can read, write, speak, understand spoken and peer review

Education

Date	Institution name	Country	Title
2015 - 2020	University of Queensland	Australia	Doctor of Philosophy
2013 - 2014	University of Queensland	Australia	Master of Engineering Science
2008 - 2012	Tianjin University	China	Bachelor of Chemical Engineering and Technology

Research Interests

Nanotechnology Biomaterials Proteins and Peptides Biomedical Engineering

Journals

Year	Citation
2025	Guo, Z., Li, Y., Xu, L., Wang, J., Lyu, J., Yang, G., . . . Zhao, C. -X. (2025). Design and optimization of bifunctional peptides for controlled core–shell nanocapsule formation. Journal of Colloid and Interface Science, 686, 599-612. DOI
2025	Jin, S., Li, X., Yang, G., Zhang, Z., Shi, J. Q., Liu, Y., & Zhao, C. -X. (2025). Active Learning-Based Prediction of Drug Combination Efficacy. ACS Nano, 19(18), 17929-17940. DOI
2025	Zewail, M. B., Yang, G., Fan, Y., Hui, Y., Zhao, C. X., & Liu, Y. (2025). Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery. Aggregate, 45 pages. DOI
2024	Jin, S., Lan, Z., Yang, G., Li, X., Shi, J. Q., Liu, Y., & Zhao, C. (2024). Computationally guided design and synthesis of dual‐drug loaded polymeric nanoparticles for combination therapy. Aggregate, 5(5), e606-1-e606-10. DOI Scopus6
2024	Orchard, M. J., Yang, G., Webber, G. B., Franks, G. V., & Zhao, C. X. (2024). Development of bioflocculants for mineral processing. Materials Today Sustainability, 28, 100965-1-100965-15. DOI Scopus2
2024	Li, Y., Weng, Y., Hui, Y., Wang, J., Xu, L., Yang, Y., . . . Zhao, C. -X. (2024). Design of stimuli-responsive minimalist heptad surfactants for stable emulsions. Communications Materials, 5(1), 229-1-229-11. DOI Scopus1 Europe PMC1
2024	Hui, Y., Liu, Y., Yang, G., Weng, Y., Hou, F., Wang, X., . . . Zhao, C. -X. (2024). Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond. Advanced Materials, 37(7), 2413779-1-2413779-37. DOI Scopus4 Europe PMC1
2023	Weng, Y., Yang, G., Li, Y., Xu, L., Chen, X., Song, H., & Zhao, C. -X. (2023). Alginate-based materials for enzyme encapsulation. Advances in Colloid and Interface Science, 318, 102957-1-102957-15. DOI Scopus52 Europe PMC17
2023	Li, Y., Yang, G., Weng, Y., Xu, L., Hou, F., Devkota, S., & Zhao, C. -X. (2023). Exploring biosurfactants as a sustainable alternative to chemical surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 677(Part A), 132291-1-132291-11. DOI Scopus9
2023	Xu, L., Wang, X., Yang, G., Zhao, Z., Weng, Y., Li, Y., . . . Zhao, C. -X. (2023). Development of a concentration-controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading. Aggregate, 4(6), e369-1-e369-14. DOI Scopus14 WoS1
2023	Yang, G., Liu, Y., Jin, S., Hui, Y., Wang, X., Xu, L., . . . Zhao, C. (2023). Phase separation‐induced nanoprecipitation for making polymer nanoparticles with high drug loading. Aggregate, 4(2), e314-1-e314-9. DOI Scopus22 WoS1
2023	Li, Y., Yang, G., Gerstweiler, L., Thang, S. H. H., & Zhao, C. -X. (2023). Design of Stimuli-Responsive Peptides and Proteins. ADVANCED FUNCTIONAL MATERIALS, 33(7), 2210387-1-2210387-31. DOI Scopus37 WoS2
2022	Zou, D., Wu, Z., Yi, X., Hui, Y., Yang, G., Liu, Y., . . . Zhao, C. -X. (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 120(1), 1-12. DOI Scopus45 WoS6 Europe PMC27
2022	Liu, Y., Yang, G., Hui, Y., Ranaweera, S., & Zhao, C. -X. (2022). Microfluidic Nanoparticles for Drug Delivery. Small, 18(36), 33 pages. DOI Scopus181 WoS35 Europe PMC64
2022	Tengjisi., Liu, Y., Zou, D., Yang, G., & Zhao, C. (2022). Bioinspired core-shell silica nanoparticles monitoring extra- and intra-cellular drug release. Journal of Colloid and Interface Science, 624, 242-250. DOI Scopus7 WoS3 Europe PMC7
2022	Xu, L., Wang, X., Liu, Y., Yang, G., Falconer, R. J., & Zhao, C. -X. (2022). Lipid Nanoparticles for Drug Delivery. Advanced NanoBiomed Research, 2(2), 1-17. DOI Scopus313 WoS73
2022	Wilson, R. J., Li, Y., Yang, G., & Zhao, C. X. (2022). Nanoemulsions for drug delivery. Particuology, 64, 85-97. DOI Scopus207 WoS55
2022	Tengjisi., Hui, Y., Fan, Y., Zou, D., Talbo, G. H., Yang, G., & Zhao, C. X. (2022). Influence of nanoparticle mechanical property on protein corona formation. Journal of Colloid and Interface Science, 606(2), 1737-1744. DOI Scopus33 WoS15 Europe PMC13
2021	Yang, G., Liu, Y., Teng, J., & Zhao, C. X. (2021). FRET ratiometric nanoprobes for nanoparticle monitoring. Biosensors, 11(12), 505-1-505-24. DOI Scopus28 WoS10 Europe PMC14
2021	Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles. Angewandte Chemie, 133(28), 15554-15563. DOI
2021	Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Inside Cover: Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles (Angew. Chem. Int. Ed. 28/2021). Angewandte Chemie International Edition, 60(28), 15114. DOI
2021	Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Innentitelbild: Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles (Angew. Chem. 28/2021). Angewandte Chemie, 133(28), 15242. DOI
2021	Yang, G., Liu, Y., & Zhao, C. X. (2021). Quantitative comparison of different fluorescent dye-loaded nanoparticles. Colloids and Surfaces B: Biointerfaces, 206, 111923-1-111923-9. DOI Scopus8 WoS7 Europe PMC7
2021	Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2021). Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles. Angewandte Chemie - International Edition, 60(28), 15426-15435. DOI Scopus19 WoS10
2021	Baby, T., Liu, Y., Yang, G., Chen, D., & Zhao, C. X. (2021). Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release. Journal of Colloid and Interface Science, 594, 474-484. DOI Scopus54 WoS29 Europe PMC15
2021	Yang, M., Gao, Y., Liu, Y., Yang, G., Zhao, C. X., & Wu, K. J. (2021). Integration of microfluidic systems with external fields for multiphase process intensification. Chemical Engineering Science, 234, 116450-1-116450-26. DOI Scopus25 WoS11
2021	Wang, H. F., Liu, Y., Yang, G., & Zhao, C. X. (2021). Macrophage-mediated cancer drug delivery. Materials Today Sustainability, 11-12, 100055-1-100055-6. DOI Scopus24 WoS13
2021	Li, W., Chen, Q., Baby, T., Jin, S., Liu, Y., Yang, G., & Zhao, C. X. (2021). Insight into drug encapsulation in polymeric nanoparticles using microfluidic nanoprecipitation. Chemical Engineering Science, 235, 116468-1-116468-8. DOI Scopus34 WoS11
2021	Tengjisi., Hui, Y., Yang, G., Fu, C., Liu, Y., & Zhao, C. X. (2021). Biomimetic core–shell silica nanoparticles using a dual-functional peptide. Journal of Colloid and Interface Science, 581(A), 185-194. DOI Scopus23 WoS12 Europe PMC6
2020	Han, F. Y., Liu, Y., Kumar, V., Xu, W., Yang, G., Zhao, C. X., . . . Smith, M. T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581, 119291-1-119291-7. DOI Scopus41 WoS25 Europe PMC15
2020	Yang, G., Liu, Y., Jin, S., & Zhao, C. X. (2020). Development of core-shell nanoparticle drug delivery systems based on biomimetic mineralization. ChemBioChem, 21(20), 2871-2879. DOI Scopus30 WoS18 Europe PMC10
2020	Zou, D., Yu, L., Sun, Q., Hui, Y., Tengjisi., Liu, Y., . . . Zhao, C. X. (2020). A general approach for biomimetic mineralization of MOF particles using biomolecules. Colloids and Surfaces B: Biointerfaces, 193, 1-9. DOI Scopus43 WoS29 Europe PMC15
2020	Liu, Y., Yang, G., Baby, T., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2020). Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation. Angewandte Chemie - International Edition, 59(12), 4720-4728. DOI Scopus120 WoS93
2020	Liu, Y., Yang, G., Jin, S., Zhang, R., Chen, P., Tengjisi., . . . Zhao, C. X. (2020). J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading. Angewandte Chemie - International Edition, 59(45), 20065-20074. DOI Scopus54 WoS27 Europe PMC20
2020	Liu, Y., Yang, G., Jin, S., Xu, L., & Zhao, C. X. (2020). Development of high-drug-loading nanoparticles. ChemPlusChem, 85(9), 2143-2157. DOI Scopus275 WoS60 Europe PMC121
2020	Wang, H. F., Liu, Y., Wang, T., Yang, G., Zeng, B., & Zhao, C. X. (2020). Tumor-microenvironment-on-a-chip for evaluating nanoparticle-loaded macrophages for drug delivery. ACS Biomaterials Science and Engineering, 6(9), 5040-5050. DOI Scopus35 WoS16 Europe PMC18
2020	Zou, D., Yu, L., Sun, Q., Hui, Y., Jisi, T., Liu, Y., . . . Zhao, C. -X. (2020). A General Approach for Encapsulation of Biomolecules Using MOF Particles. DOI
2020	Liu, Y., Yang, G., Baby, T., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2020). Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation. Angewandte Chemie, 132(12), 4750-4758. DOI
2020	Liu, Y., Yang, G., Zou, D., Hui, Y., Nigam, K., Middelberg, A. P. J., & Zhao, C. X. (2020). Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery. Industrial and Engineering Chemistry Research, 59(9), 4134-4149. DOI Scopus152 WoS83
2020	Hui, Y., Yi, X., Wibowo, D., Yang, G., Middelberg, A. P. J., Gao, H., & Zhao, C. X. (2020). Nanoparticle elasticity regulates phagocytosis and cancer cell uptake. Science Advances, 6(16), 1-11. DOI Scopus183 WoS106 Europe PMC68
2019	Peters, B. C., Wibowo, D., Yang, G. Z., Hui, Y., Middelberg, A. P. J., & Zhao, C. X. (2019). Evaluation of baiting fipronil-loaded silica nanocapsules against termite colonies in fields. Heliyon, 5(8), e02277-1-e02277-10. DOI Scopus17 WoS6 Europe PMC3
2019	Yang, G., Liu, Y., Wang, H., Wilson, R., Hui, Y., Yu, L., . . . Zhao, C. X. (2019). Bioinspired core-shell nanoparticles for hydrophobic drug delivery. Angewandte Chemie - International Edition, 58(40), 14357-14364. DOI Scopus101 WoS55 Europe PMC36
2018	Liu, Y., Hui, Y., Ran, R., Yang, G. Z., Wibowo, D., Wang, H. F., . . . Zhao, C. X. (2018). Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7(15), 1800106-1-1800106-11. DOI Scopus56 WoS41 Europe PMC21
2017	Yang, G., Wibowo, D., Yun, J., Wang, L., Middelberg, A., & Zhao, C. (2017). Biomimetic silica nanocapsules for tunable sustained release and cargo protection. Langmuir, 33(23), 5777-5785. DOI Scopus28 WoS18 Europe PMC4
2017	Wibowo, D., Yang, G., Middelberg, A., & Zhao, C. (2017). Non-chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules. Biotechnology and Bioengineering, 114(2), 335-343. DOI Scopus15 WoS12 Europe PMC4

Book Chapters

Year	Citation
2022	Yang, G., Liu, Y., & Zhao, C. (2022). Colloidal Self‐assembly of Block Copolymers for Drug Loading and Controlled Release. In G. Zhao, & Q. Yan (Eds.), Functional Materials from Colloidal Self-assembly (pp. 455-491). Wiley-VCH. DOI Scopus1

Patents

Year	Citation
2025	Zhao, C., Yang, G., & Liu, Y. (2025). PCT/AU2024/050854, Separation of minerals using short peptides or mimetics thereof. AU.
2021	Zhao, C., Liu, Y., & Yang, G. (2021). PCT/AU2020/051311, Polymer Nanoparticles. AU.

Theses

Year Citation

- Yang, G. Z. (n.d.). Core-Shell nanomaterials for drug delivery and controlled release.

Year	Citation
-	Yang, G. Z. (n.d.). Core-Shell nanomaterials for drug delivery and controlled release.

2025-2029	NHMRC Emerging Leadership Fellowship	$674,400	Innovative Chemoimmunotherapy for Metastatic Castration-Resistant Prostate Cancer
2024	University of Adelaide	$13,725	Research Small Equipment Support Scheme
2024	Australian Synchrotro	$32,784	Probing Biointeractions within Core-Shell Nanoparticles between Nanocarriers and Encapsulated Drugs while Exploring the Drug Loading Effects on Nanostructured Carrier Morphology for Enhanced Anticancer Therapy

2025	School of Chemical Engineering Coordinator	AU_Ingenuity_0007, Ingenuity
2025	Teacher	AU_Ingenuity_0007, Ingenuity
2025	Teaching Assistant	4510_ENG_3005, Research Methods & Project Management
2024	Teaching Assistant	4420_CHEM_ENG_4054, Research Project
2024	Teacher	4420_BIOPRENG_7109, Advanced Engineering of Biomaterials
2022	Course Coordinator	4220_CHEM_ENG_7062, Downstream Bioprocessing
2022	Teacher	4220_CHEM_ENG_7062, Downstream Bioprocessing

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2024	Co-Supervisor	Development of anti-swelling hydrogels for next-generation soft electronics	Doctor of Philosophy	Doctorate	Full Time	Mr Geng Yang
2023	Co-Supervisor	Development of specific metal binding biomolecules for efficient mineral separations	Doctor of Philosophy	Doctorate	Full Time	Ms Yang Yang
2023	Principal Supervisor	Development of bio-inspired cell membrane-coated (BCM) lipid nanoparticles (NPs)	Doctor of Philosophy	Doctorate	Full Time	Mr Moataz Badawy Ali Saper Zewail
2023	Principal Supervisor	A Sustainable Approach for Mineral Processing and Recycling	Doctor of Philosophy	Doctorate	Full Time	Mr Ruilin Zhao
2023	Co-Supervisor	Development of chemo-immuno nanomedicines for targeted oral drug delivery	Doctor of Philosophy	Doctorate	Full Time	Mr Yilong Fan
2022	Co-Supervisor	Development of novel bioflocculants for clay particle flocculation	Doctor of Philosophy	Doctorate	Full Time	Mr Matthias Josef Orchard

Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2021 - 2022	Co-Supervisor	Bioinspired core-shell silica nanomaterials and their nano-bio interactions	University of Queensland	Doctor of Philosophy	Doctorate	Full Time	Tengjisi
2021 - 2025	Co-Supervisor	Stimuli-responsive soft materials based on biomolecules	University of Queensland	Doctor of Philosophy	Doctorate	Full Time	Yang Li

Committee Memberships

Date	Role	Committee	Institution	Country
2024 - 2024	Member	Organising Committee	International Conference on Advanced Materials for Energy, Environment, and Health (ICAMEEH) 2024	Australia
2023 - 2023	Member	Organising Committee	International Conference on Nano Bio Intelligence 2023	Australia
2022 - 2022	Member	Future Leaders Committee	ARC Centre for Excellence for Enabling Eco-Efficient Beneficiation of Minerals	Australia
2022 - 2025	Member	Gender, Equity, Diversity and Inclusion Committee	ARC Centre for Excellence for Enabling Eco-Efficient Beneficiation of Minerals	Australia
2022 - 2022	Member	Organising Committee	Exploration Australian Crossdisciplinarity Webinar 2022	Australia
2020 - 2020	Member	Organising Committee	International Conference on Nanoscience and Nanotechnology (ICONN) 2020	Australia

Memberships

Date	Role	Membership	Country
2021 - ongoing	Member	Australasian Colloid and Interface Society	Australia
2021 - ongoing	Member	Drug Delivery Australia	Australia
2021 - ongoing	Member	Australian Chapter of the Controlled Release Society	Australia

Review, Assessment, Editorial and Advice

Date Title Type Institution Country

2021 - ongoing Novel Reagent Technologies for Arsenic Minerals Thesis Review The University of Queensland Australia

Date	Title	Type	Institution	Country
2021 - ongoing	Novel Reagent Technologies for Arsenic Minerals	Thesis Review	The University of Queensland	Australia

Email: guangze.yang@adelaide.edu.au

Guangze Yang

Appointments

Awards and Achievements

Language Competencies

Education

Research Interests

Journals

Book Chapters

Patents

Theses

Current Higher Degree by Research Supervision (University of Adelaide)

Other Supervision Activities

Committee Memberships

Memberships

Review, Assessment, Editorial and Advice

Connect With Me

External Profiles