Guangze Yang

Research Interests

Nanotechnology Biomaterials Proteins and Peptides Biomedical Engineering

Dr Guangze Yang

NHMRC Externally-Funded Research Fellow

School of Chemical Engineering

College of Engineering and Information Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Guangze Yang is an NHMRC Emerging Leadership Fellow at the School of Chemical Engineering, The University of Adelaide. His research focuses on the development of nanomaterials for biomedical applications, with a particular emphasis on drug delivery and biomimetic materials. His interdisciplinary work spans nanomedicine, polymer science, and bioinspired materials, integrating fundamental research with translational potential.Dr Yang has published extensively in peer-reviewed journals, with his work receiving citations that reflect its impact within the field. His research has been supported by competitive funding, including the NHMRC Emerging Leadership Fellowship (2025–2029) for the project Innovative Chemoimmunotherapy for Metastatic Castration-Resistant Prostate Cancer. He is actively involved in collaborations with academic and industry partners and contributes to mentoring students and early-career researchers.

My research is centred on the design and development of advanced nanomaterials for drug delivery, biomimetic systems, and sustainable technologies. A key focus is the engineering of polymeric and lipid nanoparticles with high drug-loading capacity, targeted delivery, and controlled release properties. I also work on microfluidic-based nanoparticle synthesis and advanced drying techniques to improve stability and scalability.

In addition to drug delivery, my research explores biofunctional materials, including peptides, proteins, and stimuli-responsive systems. I investigate how material properties influence cellular interactions, immune responses, and therapeutic efficacy. My work extends to the development of biomolecules for mineral processing, contributing to environmentally sustainable approaches in resource industries.

Through my NHMRC Fellowship, I am investigating novel chemoimmunotherapy strategies for cancer therapy, focusing on nanoparticle-based immunomodulators to enhance treatment effectiveness while minimising side effects. My broader research interests involve bridging fundamental nanomaterial science with practical applications, contributing to advancements in healthcare and industrial biotechnology.

Date Position Institution name
2025 - 2029 NHMRC Emerging Leadership Fellowship University of Adelaide
2022 - 2024 Postdoctoral research fellow University of Adelaide
2020 - 2022 Postdoctoral research fellow University of Queensland

Date Type Title Institution Name Country Amount
2024 Recognition Top Scholar (Drug Delivery) - Prior 5 Years ScholarGPS United States -

Language Competency
Chinese (Mandarin) Can read, write, speak, understand spoken and peer review
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
2015 - 2020 University of Queensland Australia Doctor of Philosophy
2013 - 2014 University of Queensland Australia Master of Engineering Science
2008 - 2012 Tianjin University China Bachelor of Chemical Engineering and Technology

Year Citation
2025 Guo, Z., Li, Y., Xu, L., Wang, J., Lyu, J., Yang, G., . . . Zhao, C. -X. (2025). Design and optimization of bifunctional peptides for controlled core–shell nanocapsule formation. Journal of Colloid and Interface Science, 686, 599-612.
DOI Scopus3 WoS3 Europe PMC1
2025 Jin, S., Li, X., Yang, G., Zhang, Z., Shi, J. Q., Liu, Y., & Zhao, C. -X. (2025). Active Learning-Based Prediction of Drug Combination Efficacy. ACS Nano, 19(18), 17929-17940.
DOI Scopus1 WoS1
2025 Zewail, M. B., Yang, G., Fan, Y., Hui, Y., Zhao, C., & Liu, Y. (2025). Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery. Aggregate, 6(7), e70054-1-e70054-45.
DOI Scopus11 WoS10
2025 Yang, G., Liu, Y., Devkota, S. R., Hui, Y., Zhao, R., Li, Y., . . . Zhao, C. (2025). A Sustainable Biotechnology Approach for Mineral Separation. Advanced Functional Materials, e04992-1-e04992-16.
DOI
2025 Zhang, F., Liu, Y., Wang, J., Zhang, H., Yu, W., Sang, Y., . . . Wang, X. (2025). An automated microfluidic biosensor with bispecific rabbit monoclonal antibody and nanozyme-bioenzyme composite for dual antibiotic detection. Bmemat, 15 pages.
DOI
2024 Jin, S., Lan, Z., Yang, G., Li, X., Shi, J. Q., Liu, Y., & Zhao, C. (2024). Computationally guided design and synthesis of dual‐drug loaded polymeric nanoparticles for combination therapy. Aggregate, 5(5), e606-1-e606-10.
DOI Scopus10 WoS10
2024 Orchard, M. J., Yang, G., Webber, G. B., Franks, G. V., & Zhao, C. X. (2024). Development of bioflocculants for mineral processing. Materials Today Sustainability, 28, 100965-1-100965-15.
DOI Scopus3 WoS3
2024 Li, Y., Weng, Y., Hui, Y., Wang, J., Xu, L., Yang, Y., . . . Zhao, C. -X. (2024). Design of stimuli-responsive minimalist heptad surfactants for stable emulsions. Communications Materials, 5(1), 229-1-229-11.
DOI Scopus1 WoS1 Europe PMC1
2024 Hui, Y., Liu, Y., Yang, G., Weng, Y., Hou, F., Wang, X., . . . Zhao, C. -X. (2024). Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond. Advanced Materials, 37(7), 2413779-1-2413779-37.
DOI Scopus15 WoS16 Europe PMC10
2023 Weng, Y., Yang, G., Li, Y., Xu, L., Chen, X., Song, H., & Zhao, C. -X. (2023). Alginate-based materials for enzyme encapsulation. Advances in Colloid and Interface Science, 318, 102957-1-102957-15.
DOI Scopus76 WoS65 Europe PMC29
2023 Li, Y., Yang, G., Weng, Y., Xu, L., Hou, F., Devkota, S., & Zhao, C. -X. (2023). Exploring biosurfactants as a sustainable alternative to chemical surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 677(Part A), 132291-1-132291-11.
DOI Scopus17 WoS13
2023 Xu, L., Wang, X., Yang, G., Zhao, Z., Weng, Y., Li, Y., . . . Zhao, C. -X. (2023). Development of a concentration-controlled sequential nanoprecipitation for making lipid nanoparticles with high drug loading. Aggregate, 4(6), e369-1-e369-14.
DOI Scopus18 WoS18
2023 Yang, G., Liu, Y., Jin, S., Hui, Y., Wang, X., Xu, L., . . . Zhao, C. (2023). Phase separation‐induced nanoprecipitation for making polymer nanoparticles with high drug loading. Aggregate, 4(2), e314-1-e314-9.
DOI Scopus26 WoS25
2023 Li, Y., Yang, G., Gerstweiler, L., Thang, S. H. H., & Zhao, C. -X. (2023). Design of Stimuli-Responsive Peptides and Proteins. ADVANCED FUNCTIONAL MATERIALS, 33(7), 2210387-1-2210387-31.
DOI Scopus53 WoS48
2022 Zou, D., Wu, Z., Yi, X., Hui, Y., Yang, G., Liu, Y., . . . Zhao, C. -X. (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 120(1), 1-12.
DOI Scopus62 WoS68 Europe PMC49
2022 Liu, Y., Yang, G., Hui, Y., Ranaweera, S., & Zhao, C. -X. (2022). Microfluidic Nanoparticles for Drug Delivery. Small, 18(36), 33 pages.
DOI Scopus232 WoS206 Europe PMC99
2022 Tengjisi., Liu, Y., Zou, D., Yang, G., & Zhao, C. (2022). Bioinspired core-shell silica nanoparticles monitoring extra- and intra-cellular drug release. Journal of Colloid and Interface Science, 624, 242-250.
DOI Scopus8 WoS10 Europe PMC9
2022 Xu, L., Wang, X., Liu, Y., Yang, G., Falconer, R. J., & Zhao, C. -X. (2022). Lipid Nanoparticles for Drug Delivery. Advanced NanoBiomed Research, 2(2), 1-17.
DOI Scopus400 WoS344
2022 Wilson, R. J., Li, Y., Yang, G., & Zhao, C. X. (2022). Nanoemulsions for drug delivery. Particuology, 64, 85-97.
DOI Scopus269 WoS225
2022 Tengjisi., Hui, Y., Fan, Y., Zou, D., Talbo, G. H., Yang, G., & Zhao, C. X. (2022). Influence of nanoparticle mechanical property on protein corona formation. Journal of Colloid and Interface Science, 606(2), 1737-1744.
DOI Scopus40 WoS33 Europe PMC28
2021 Yang, G., Liu, Y., Teng, J., & Zhao, C. X. (2021). FRET ratiometric nanoprobes for nanoparticle monitoring. Biosensors, 11(12), 505-1-505-24.
DOI Scopus35 WoS32 Europe PMC19
2021 Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles. Angewandte Chemie, 133(28), 15554-15563.
DOI
2021 Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Inside Cover: Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles (Angew. Chem. Int. Ed. 28/2021). Angewandte Chemie International Edition, 60(28), 15114.
DOI
2021 Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2021). Innentitelbild: Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles (Angew. Chem. 28/2021). Angewandte Chemie, 133(28), 15242.
DOI
2021 Yang, G., Liu, Y., & Zhao, C. X. (2021). Quantitative comparison of different fluorescent dye-loaded nanoparticles. Colloids and Surfaces B: Biointerfaces, 206, 111923-1-111923-9.
DOI Scopus9 WoS11 Europe PMC8
2021 Yang, G., Liu, Y., Hui, Y., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2021). Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles. Angewandte Chemie - International Edition, 60(28), 15426-15435.
DOI Scopus20 WoS19
2021 Baby, T., Liu, Y., Yang, G., Chen, D., & Zhao, C. X. (2021). Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release. Journal of Colloid and Interface Science, 594, 474-484.
DOI Scopus64 WoS60 Europe PMC30
2021 Yang, M., Gao, Y., Liu, Y., Yang, G., Zhao, C. X., & Wu, K. J. (2021). Integration of microfluidic systems with external fields for multiphase process intensification. Chemical Engineering Science, 234, 116450-1-116450-26.
DOI Scopus29 WoS26
2021 Wang, H. F., Liu, Y., Yang, G., & Zhao, C. X. (2021). Macrophage-mediated cancer drug delivery. Materials Today Sustainability, 11-12, 100055-1-100055-6.
DOI Scopus26 WoS25
2021 Li, W., Chen, Q., Baby, T., Jin, S., Liu, Y., Yang, G., & Zhao, C. X. (2021). Insight into drug encapsulation in polymeric nanoparticles using microfluidic nanoprecipitation. Chemical Engineering Science, 235, 116468-1-116468-8.
DOI Scopus35 WoS31
2021 Tengjisi., Hui, Y., Yang, G., Fu, C., Liu, Y., & Zhao, C. X. (2021). Biomimetic core–shell silica nanoparticles using a dual-functional peptide. Journal of Colloid and Interface Science, 581(A), 185-194.
DOI Scopus24 WoS16 Europe PMC11
2020 Han, F. Y., Liu, Y., Kumar, V., Xu, W., Yang, G., Zhao, C. X., . . . Smith, M. T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581, 119291-1-119291-7.
DOI Scopus43 WoS40 Europe PMC27
2020 Yang, G., Liu, Y., Jin, S., & Zhao, C. X. (2020). Development of core-shell nanoparticle drug delivery systems based on biomimetic mineralization. ChemBioChem, 21(20), 2871-2879.
DOI Scopus33 WoS28 Europe PMC14
2020 Zou, D., Yu, L., Sun, Q., Hui, Y., Tengjisi., Liu, Y., . . . Zhao, C. X. (2020). A general approach for biomimetic mineralization of MOF particles using biomolecules. Colloids and Surfaces B: Biointerfaces, 193, 1-9.
DOI Scopus44 WoS42 Europe PMC24
2020 Liu, Y., Yang, G., Baby, T., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. X. (2020). Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation. Angewandte Chemie - International Edition, 59(12), 4720-4728.
DOI Scopus135 WoS148
2020 Liu, Y., Yang, G., Jin, S., Zhang, R., Chen, P., Tengjisi., . . . Zhao, C. X. (2020). J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading. Angewandte Chemie - International Edition, 59(45), 20065-20074.
DOI Scopus57 WoS56 Europe PMC32
2020 Liu, Y., Yang, G., Jin, S., Xu, L., & Zhao, C. X. (2020). Development of high-drug-loading nanoparticles. ChemPlusChem, 85(9), 2143-2157.
DOI Scopus330 WoS296 Europe PMC176
2020 Wang, H. F., Liu, Y., Wang, T., Yang, G., Zeng, B., & Zhao, C. X. (2020). Tumor-microenvironment-on-a-chip for evaluating nanoparticle-loaded macrophages for drug delivery. ACS Biomaterials Science and Engineering, 6(9), 5040-5050.
DOI Scopus41 WoS39 Europe PMC26
2020 Zou, D., Yu, L., Sun, Q., Hui, Y., Jisi, T., Liu, Y., . . . Zhao, C. -X. (2020). A General Approach for Encapsulation of Biomolecules Using MOF Particles.
DOI
2020 Liu, Y., Yang, G., Baby, T., Tengjisi., Chen, D., Weitz, D. A., & Zhao, C. (2020). Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation. Angewandte Chemie, 132(12), 4750-4758.
DOI
2020 Liu, Y., Yang, G., Zou, D., Hui, Y., Nigam, K., Middelberg, A. P. J., & Zhao, C. X. (2020). Formulation of nanoparticles using mixing-induced nanoprecipitation for drug delivery. Industrial and Engineering Chemistry Research, 59(9), 4134-4149.
DOI Scopus165 WoS144
2020 Hui, Y., Yi, X., Wibowo, D., Yang, G., Middelberg, A. P. J., Gao, H., & Zhao, C. X. (2020). Nanoparticle elasticity regulates phagocytosis and cancer cell uptake. Science Advances, 6(16), 1-11.
DOI Scopus213 WoS201 Europe PMC145
2019 Peters, B. C., Wibowo, D., Yang, G. Z., Hui, Y., Middelberg, A. P. J., & Zhao, C. X. (2019). Evaluation of baiting fipronil-loaded silica nanocapsules against termite colonies in fields. Heliyon, 5(8), e02277-1-e02277-10.
DOI Scopus19 WoS10 Europe PMC5
2019 Yang, G., Liu, Y., Wang, H., Wilson, R., Hui, Y., Yu, L., . . . Zhao, C. X. (2019). Bioinspired core-shell nanoparticles for hydrophobic drug delivery. Angewandte Chemie - International Edition, 58(40), 14357-14364.
DOI Scopus112 WoS102 Europe PMC62
2018 Liu, Y., Hui, Y., Ran, R., Yang, G. Z., Wibowo, D., Wang, H. F., . . . Zhao, C. X. (2018). Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7(15), 1800106-1-1800106-11.
DOI Scopus58 WoS53 Europe PMC34
2017 Yang, G., Wibowo, D., Yun, J., Wang, L., Middelberg, A., & Zhao, C. (2017). Biomimetic silica nanocapsules for tunable sustained release and cargo protection. Langmuir, 33(23), 5777-5785.
DOI Scopus30 WoS27 Europe PMC12
2017 Wibowo, D., Yang, G., Middelberg, A., & Zhao, C. (2017). Non-chromatographic bioprocess engineering of a recombinant mineralizing protein for the synthesis of silica nanocapsules. Biotechnology and Bioengineering, 114(2), 335-343.
DOI Scopus15 WoS14 Europe PMC8

Year Citation
2022 Yang, G., Liu, Y., & Zhao, C. (2022). Colloidal Self‐assembly of Block Copolymers for Drug Loading and Controlled Release. In G. Zhao, & Q. Yan (Eds.), Functional Materials from Colloidal Self-assembly (pp. 455-491). Wiley-VCH.
DOI Scopus1

Year Citation
2025 Zhao, C., Yang, G., & Liu, Y. (2025). PCT/AU2024/050854, Separation of minerals using short peptides or mimetics thereof. AU.
2021 Zhao, C., Liu, Y., & Yang, G. (2021). PCT/AU2020/051311, Polymer Nanoparticles. AU.

Year Citation
- Yang, G. Z. (n.d.). Core-Shell nanomaterials for drug delivery and controlled release.
2025-2029 NHMRC Emerging Leadership Fellowship $674,400 Innovative Chemoimmunotherapy for Metastatic Castration-Resistant Prostate Cancer
2025 Australian Synchrotro $65,568 Development of anti-swelling hydrogels by hydrophobic association for next-generation soft bioelectronics
2024 University of Adelaide $13,725 Research Small Equipment Support Scheme
2024 Australian Synchrotro $32,784 Probing Biointeractions within Core-Shell Nanoparticles between Nanocarriers and Encapsulated Drugs while Exploring the Drug Loading Effects on Nanostructured Carrier Morphology for Enhanced Anticancer Therapy
2023 University of Adelaide FHMS Internal early grant development $30,274 The development of optimised high drug-load nanomedicines for the treatment of multiple myeloma
2025 Teaching Assistant Research Project 4520_UNIAD_CHEM_ENG_4054
2025 Teacher Advanced Engineering of Biomaterials 4520_UNIAD_BIOPRENG_7109
2025 School of Chemical Engineering Coordinator Ingenuity AU_Ingenuity_0007
2025 Teacher Ingenuity AU_Ingenuity_0007
2025 Teaching Assistant Research Methods & Project Management, Semester 2 4510_ENG_3005
2025 Teaching Assistant Research Methods & Project Management, Semester 1 4510_ENG_3005
2024 Teaching Assistant Research Project 4420_CHEM_ENG_4054
2024 Teacher Advanced Engineering of Biomaterials 4420_BIOPRENG_7109
2022 Course Coordinator Downstream Bioprocessing 4220_CHEM_ENG_7062
2022 Teacher Downstream Bioprocessing 4220_CHEM_ENG_7062

Date Role Research Topic Program Degree Type Student Load Student Name
2024 Co-Supervisor Development of anti-swelling hydrogels for next-generation soft electronics Doctor of Philosophy Doctorate Full Time Mr Geng Yang
2023 Co-Supervisor Development of specific metal binding biomolecules for efficient mineral separations Doctor of Philosophy Doctorate Full Time Ms Yang Yang
2023 Principal Supervisor Development of bio-inspired cell membrane-coated (BCM) lipid nanoparticles (NPs) Doctor of Philosophy Doctorate Full Time Mr Moataz Badawy Ali Saper Zewail
2023 Principal Supervisor A Sustainable Approach for Mineral Processing and Recycling Doctor of Philosophy Doctorate Full Time Mr Ruilin Zhao
2023 Co-Supervisor Development of chemo-immuno nanomedicines for targeted oral drug delivery Doctor of Philosophy Doctorate Full Time Mr Yilong Fan
2022 Co-Supervisor Development of novel bioflocculants for clay particle flocculation Doctor of Philosophy Doctorate Full Time Mr Matthias Josef Orchard

Date Role Research Topic Location Program Supervision Type Student Load Student Name
2021 - 2022 Co-Supervisor Bioinspired core-shell silica nanomaterials and their nano-bio interactions University of Queensland Doctor of Philosophy Doctorate Full Time Tengjisi
2021 - 2025 Co-Supervisor Stimuli-responsive soft materials based on biomolecules University of Queensland Doctor of Philosophy Doctorate Full Time Yang Li

Date Role Committee Institution Country
2025 - 2025 Member Organising Committee International Conference on Nano Bio Intelligence 2025 Australia
2024 - 2024 Member Organising Committee International Conference on Advanced Materials for Energy, Environment, and Health (ICAMEEH) 2024 Australia
2023 - 2023 Member Organising Committee International Conference on Nano Bio Intelligence 2023 Australia
2022 - 2022 Member Future Leaders Committee ARC Centre for Excellence for Enabling Eco-Efficient Beneficiation of Minerals Australia
2022 - 2025 Member Gender, Equity, Diversity and Inclusion Committee ARC Centre for Excellence for Enabling Eco-Efficient Beneficiation of Minerals Australia
2022 - 2022 Member Organising Committee Exploration Australian Crossdisciplinarity Webinar 2022 Australia
2020 - 2020 Member Organising Committee International Conference on Nanoscience and Nanotechnology (ICONN) 2020 Australia

Date Role Membership Country
2021 - ongoing Member Australasian Colloid and Interface Society Australia
2021 - ongoing Member Drug Delivery Australia Australia
2021 - ongoing Member Australian Chapter of the Controlled Release Society Australia

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