Grant Buchanan

Dr Grant Buchanan

Head of Cancer Biology Group

Adelaide Medical School

Faculty of Health and Medical Sciences


Dr Buchanan leads a dynamic and contemporary research team, the Cancer Biology Group, at the Basil Hetzel Institute for Translational Research. This research group aims to fuse innovative molecular technology to pertinent clinical questions. The overall research objectives are to (i) provide a more holistic insight into the determinants of cancer initiation and progression, (ii) define comprehensive network models of nuclear receptor function in normal cells and in cancer, (iii) identify the inter-relationship between nuclear receptor networks, paracrine signalling and the cellular and tumour microenvironment, and (iv) generate and disseminate tools and reagents for nuclear receptor research.

During Dr Buchanan's PhD and early postdoctoral studies, he was mentored by Professors Villis Marshall and Wayne Tilley, who are internationally regarded for their work on androgen receptor (AR) in prostate cancer. Between 2006-2007, Dr Buchanan conducted the overseas component his CJ Martin Fellowship at the University of Southern California under the mentorship of Professors Gerry Coetzee, Mike Stallcup and Ron Ross (dec.). Working with that highly regarded and multidisciplinary team, Dr Buchanan established skills and resources in genome-scale analysis of steroid receptor action, cofactors, ChIP-chip, Chip-seq, transcription profiling, microarray, bioinformatics and network analysis, and established a set of strategic international collaborations. Returning to Australia, Dr Buchanan received one of only four nationally awarded Young Investigator Awards (2007) from the Prostate Cancer Foundation of Australia. In recognition of his research to date, in 2010 CIA Buchanan was awarded the Prostate Cancer Foundation of Australia National Young Researcher of the Year.

Dr Buchanan has held several prestigious research training fellowships; first from the Cancer Council of South Australia, a training award from the United States Department of Defense, a NHMRC CJ Martin Fellowship and lastly a NHMRC CDA Level A. Over the last 10 years, CIA Buchanan has supervised 7 Honours students (6/7 attaining first class; 2 as principal) and 8 PhD students (5 awarded, 3 current; 5 as principal).

Biography/ Background

Dr Buchanan leads a dynamic and contemporary research team, the Cancer Biology Group, at the Basil Hetzel Institute for Translational Research. This research group aims to fuse innovative molecular technology to pertinent clinical questions. The overall research objectives are to (i) provide a more holistic insight into the determinants of cancer initiation and progression, (ii) define comprehensive network models of nuclear receptor function in normal cells and in cancer, (iii) identify the inter-relationship between nuclear receptor networks, paracrine signalling and the cellular and tumour microenvironment, and (iv) generate and disseminate tools and reagents for nuclear receptor research.

During Dr Buchanan's PhD and early postdoctoral studies, he was mentored by Professors Villis Marshall and Wayne Tilley, who are internationally regarded for their work on androgen receptor (AR) in prostate cancer. Between 2006-2007, Dr Buchanan conducted the overseas component his CJ Martin Fellowship at the University of Southern California under the mentorship of Professors Gerry Coetzee, Mike Stallcup and Ron Ross (dec.). Working with that highly regarded and multidisciplinary team, Dr Buchanan established skills and resources in genome-scale analysis of steroid receptor action, cofactors, ChIP-chip, Chip-seq, transcription profiling, microarray, bioinformatics and network analysis, and established a set of strategic international collaborations. Returning to Australia, Dr Buchanan received one of only four nationally awarded Young Investigator Awards (2007) from the Prostate Cancer Foundation of Australia. In recognition of his research to date, in 2010 CIA Buchanan was awarded the Prostate Cancer Foundation of Australia National Young Researcher of the Year.

Dr Buchanan has held several prestigious research training fellowships; first from the Cancer Council of South Australia, a training award from the United States Department of Defense, a NHMRC CJ Martin Fellowship and lastly a NHMRC CDA Level A. Over the last 10 years, CIA Buchanan has supervised 7 Honours students (6/7 attaining first class; 2 as principal) and 8 PhD students (5 awarded, 3 current; 5 as principal).

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  • Appointments

    Date Position Institution name
    2016 Radiation Oncology Registrar (non accredited) Canberra Hospital
    2016 Resident Medical Officer Royal Adelaide Hospital
    2015 Medical Intern Royal Adelaide Hospital
    2014 Affiliate Lecturer University of Adelaide
    2009 - 2014 Senior Lecturer University of Adelaide
    2006 - 2008 CJ Martin Biomedical Research Fellow University of Southern California
    2003 - 2005 Research Associate University of Adelaide
    1994 - 1997 Research Assistant Flinders University
    1991 - 1993 Chemistry Tutor University of Tasmania
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2012 Award Deane O Southgate Prize for Research Flinders Medical School
    2010 Award National Young Research of the Year Prostate Cancer Foundation of Australia
    2009 Award Career Development Award (L1) National Health and Medical Research Council of Australia
    2007 Award Young Investigator Award Prostate Cancer Foundation of Australia
    2005 Fellowship CJ Martin Biomedical Fellowship National Health and Medical Research Council of Australia
    2005 Award Trave Award Prostate Cancer Foundation of Australia
    2004 Award Travel Award, International Society of Endocrinology
    2004 Award Postdoctoral Traineeship Award US Department of Defense
    2003 Fellowship Research Fellowship The Cancer Council of South Australia
    2001 Award Lyn Wrigley Postgraduate Research Award Flinders University
    1999 Award Young Researcher Award Prostate Cancer Foundation of Australia
    1998 Scholarship Postgraduate Research Scholarship Flinders University
    1992 Scholarship Scholarship, National Heart Foundation
  • Education

    Date Institution name Country Title
    2014 Flinders University Australia Doctor of Medicine (MD
    2003 Flinders University Australia Doctor of Philosophy (PhD)
    1994 University of Adelaide Australia Bachelor of Science with Honours (BSc Hons)
    1993 University of Tasmania Australia Bachelor of Science (BSc)
  • Research Interests

Total Career Funding: $2.98 million

Funding Last 5 years: $2.06 million

2008 - 2011 Buchanan G (CIA). YI02. Prostate Cancer Foundation of Australia Young Investigator Award. A novel regulator of androgen receptor function in prostate cancer. $400,000
2010 - 2013  Buchanan G (CIA). ID:627018. Androgen receptor action in the prostate cancer microenvironment. National Health and Medical Research Council Career Development Award (Level A). $377,000
2011 - 2012 Buchanan G (CIA). Butler LM, Key T. PG2210. Prostate Cancer Foundation of Australia. Targeting chemokine signaling in prostate cancer. $250,000
2011 - 2013 Buchanan G (CIA). Tilley WD, Green GL, Coetzee GA. DP110101101. Australian Research Council. Molecular dynamics of steroid receptor crosstalk. $350,000
2011 Pinnock C, Buchanan G, Chopra S, Kopsaftis T. Chemokine signalling in prostate cancer. Foundation Daw Park, Repatriation General Hospital. AUD$23,000
2012 Pinnock C, Buchanan G, Kopsaftis T, Drew P. DNA methylation in prostate cancer: a pathway to the discovery of novel prognostic biomarkers and future therapies. Foundation Daw Park, Repatriation General hospital. AUD$19,900
2012 Buchanan G (CIA). Brian and Maxine Newell Prostate Cancer Foundation. Equipment Grant. $27,500
2013 Buchanan G (CIA), Australian Prostate Cancer, Cancer Innovation Award. Unlocking the prognostic potential of the prostate cancer microenvironment. $41,967
2012 - 2015 Buchanan G (CIA), Taylor RA, Need EF. APP1032970. Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme in conjunction with the NHMRC (Cancer Australia / Prostate Cancer Foundation of Australia). Androgen receptor in the prostate cancer microenvironment. $575,584
Higher Degree Teaching
Ph.D. Students graduated as principal supervisor
2008 Eleanor Need, Division of Medicine, University of Adelaide. March 2008.
2011 Andrew Trotta, Division of Medicine, University of Adelaide. December 2011.
2013 Damien Leach, Division of Medicine, University of Adelaide. August 2013.
2014 Erin Swinstead, Division of Medicine, University of Adelaide. September 2014.
2014 Lauren Giorgio, Division of Medicine, University of Adelaide. November 2014.
Honours students graduated as principal supervisor
2003 Albert Cheong Shea Wei, Flinders University, 1st Class
2005 Karen Chiam HuiQin, University of Adelaide, 1st Class
2010 Tiffany Harris, University of Adelaide, 1st Class
Ph.D. Students graduated as co-supervisor
2009 Amelia Peters, Division of Medicine, University of Adelaide. May 2008.
2012 Sean Martin, Division of Medicine, University of Adelaide. June 2012.
2012

Miriam Butler, Division of Medicine, University of Adelaide. August 2012.

Honours students graduated as co-supervisor
2003 Amelia Peters, Flinders University 1st Class
2003 Joanna Gillis, Flinders University 1st Class
2005 Alexandra Ruiz, University of Adelaide, 1st Class
2005 Alice Ming Lee, University of Adelaide, 2nd Class

 

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  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2011 - 2014 Co-Supervisor Steroid Receptor Crosstalk in Breast Cancer Cells Doctor of Philosophy Doctorate Full Time Miss Erin Elizabeth Swinstead
    2010 - 2014 Principal Supervisor Androgen signalling in the prostate cancer microenvironment Doctor of Philosophy Doctorate Full Time Mr Damien Alexander Leach
    2008 - 2011 Principal Supervisor Characterisation of the Co-chaperone Small Glutamine-rich Tetratricopeptide Repeat containing Protein Alpha as a Regulator of Androgen Receptor Activity in Prostate Cancer Cells Doctor of Philosophy Doctorate Full Time Dr Andrew Trotta
    2008 - 2013 Co-Supervisor The Role of Modifiable Risk Factors in the Presence and Development of Lower Urinary Tract Symptoms (LUTS) and Sexual Dysfunction in Ageing Men Doctor of Philosophy Doctorate Full Time Dr Sean Martin
    2008 - 2012 Co-Supervisor The Role of Small Glutamine-Rich Tetratricopeptide Repeat Containing Protein Alpha in Female Reproductive Tissues Doctor of Philosophy Doctorate Full Time Ms Miriam Simone Butler
    2004 - 2008 Co-Supervisor Androgen Signalling in Normal and Malignant Breast Epithelial Cells Doctor of Philosophy Doctorate Part Time Ms Amelia Peters
    2004 - 2008 Principal Supervisor Androgens and Androgen Receptor Signalling in Men Doctor of Philosophy Doctorate Full Time Dr Eleanor Need
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  • Board Memberships

    Date Role Board name Institution name Country
    1998 - 1999 Representative School of Medicine Faculty Board Flinders University
  • Committee Memberships

    Date Role Committee Institution Country
    2011 - ongoing Member Research Committee, South Australian Prostate Cancer Clinical Outcomes Collaborative
    2008 - ongoing Member Tissue Access Committee, The Australian Prostate Cancer BioResource
    1997 - 1999 Member Postgraduate Research Students in the School of Medicine (PRISM)
  • Position: Head of Cancer Biology Group
  • Phone: 82227410
  • Email: grant.buchanan@adelaide.edu.au
  • Fax: 8222 5896
  • Campus: The Queen Elizabeth Hospital
  • Building: QEH - Basil Hetzel Institute for Translationa, floor 1
  • Org Unit: Medical Sciences

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