Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Giri Krishnan is an Otolaryngology, Head and Neck Surgical trainee. He completed his medical degree at The University of Adelaide in 2013 and a Master of Clinical Science at the Joanna Briggs Institute in 2017. He is currently undertaking a PhD as part of a 'Surgeon-Scientist Training Program' investigating the application of novel nanoparticles to advance diagnosis and treatment of patients with head and neck cancer.
Giri was awarded the 2018 Fulbright scholarship, and will undertake a research fellowship, as part of his PhD, at Stanford University in California, USA in 2019. He will work in the Rosenthal Laboratory where he will have access to state of the art preclinical imaging facilities. He aims to use advanced magnetic nanotracers for molecular imaging to identify microscopic metastatic cancer deposits in a mouse head and neck cancer xenograft model and study the use of fluorescent probes for real-time optical imaging during head and neck surgery.
- My Research
- Grants and Funding
- Professional Activities
My PhD investigates the role of nanotechnology to advance diagnosis and treatment of patients with head and neck cancer. This research brings together a team of expert South Australian Head and Neck Surgeons from the Royal Adelaide Hospital with Bioengineers from the Future Industries Institute and scientists from the Basil Hetzel Institute to translate cutting-edge and innovative nanoparticle technology into clinical practice. My supervisors are Professor PJ Wormald, Professor Benjamin Thierry and Dr. Andrew Foreman.
Oral cancer is the 12th most common cancer in the world and contributes a significant public health burden because of the aggressive nature of this disease and its associated poor patient survival outcomes.
Nanoparticles offer several exciting opportunities in oral cancer research. Nanoparticles can be used as ‘tracers’ to help us detect the spread of microscopic cancer in imaging studies, by labelling them with immune antibodies that are specifically attracted to cancer cells. Accurate detection of cancer is critical because a missed diagnosis portends an extremely poor prognosis. They can also be used in a therapeutic fashion. For example they can be designed to deliver chemotherapeutic drugs directly to the tumour, reducing the systemic toxic effects of therapy. In a similar fashion they can be used for “radiosensitisation” of tumours by enhancing the effects of radiotherapy on the tumour. My team have manufactured magnetic nanotracers and have designed a unique hand-held 'magnetometer probe' that will enable us to perform sentinel lymph node mapping using a novel magnetic technique in the head and neck to identify the regional spread of tumour to the lymph nodes in the neck.
The specific objectives of my PhD are to initially develop a small animal model of oral cancer and then to explore in this model, the feasibility of using advanced nanoparticles in each of these innovative diagnostic and treatment strategies. I will work with our team of experienced Head and Neck Surgeons to trial these treatment strategies in human patients.
As part of my PhD I will also spend 12 months at Stanford under the supervision of Professor Eben Rosenthal analysing the role of nanoparticles for “real-time optical image guided surgery”. This emerging technique involves labeling nanoparticles with a fluorescent tag, which binds to cancer cells so that we can visualize the tumour margins during surgical resection. This improves our chances of complete tumour clearance, which we know gives our patients a much better chance of survival.
Realisation of our aims could revolutionise the treatment paradigm of our patients giving them more efficient and accurate diagnoses and improving the success, while reducing the associated morbidity, of our medical, radiotherapeutic and surgical treatment.
Date Position Institution name 2015 - 2018 Clinical Associate Lecturer University of Adelaide, Adelaide
Date Institution name Country Title 2017 University of Adelaide, Adelaide Australia PhD 2015 - 2017 University of Adelaide, Adelaide Australia MClinSc 2007 - 2013 University of Adelaide, Adelaide Australia MBBS
Date Title Institution Country 2018 Otolaryngology, Head and Neck Surgery Surgical Education Training Royal Australasian College of Surgeons Australia 2015 - 2017 Surgical Residency Royal Adelaide Hospital, Adelaide Australia 2014 - 2015 Internship Royal Adelaide Hospital, Adelaide Australia
Year Citation 2022 Krishnan, G., van den Berg, N. S., Nishio, N., Kapoor, S., Pei, J., Freeman, L., . . . Rosenthal, E. L. (2022). Fluorescent Molecular Imaging Can Improve Intraoperative Sentinel Margin Detection in Oral Squamous Cell Carcinoma. Journal of Nuclear Medicine, 63(8), 1162-1168.
DOI Scopus4 WoS4 Europe PMC1
2022 Krishnan, G., Cousins, A., Pham, N., Milanova, V., Nelson, M., Krishnan, S., . . . Thierry, B. (2022). Preclinical evaluation of a mannose-labeled magnetic tracer for enhanced sentinel lymph node retention in the head and neck. Nanomedicine: Nanotechnology, Biology and Medicine, 42, 102546-1-102546-11.
DOI Scopus2 WoS3 Europe PMC2
2022 Krishnan, G., Cousins, A., Pham, N., Milanova, V., Nelson, M., Krishnan, S., . . . Krishnan, S. (2022). Preclinical feasibility of robot-assisted sentinel lymph node biopsy using multi-modality magnetic and fluorescence guidance in the head and neck. Head and Neck, 44(12), 2696-2707.
2021 Lee, Y. J., Krishnan, G., Nishio, N., van den Berg, N. S., Lu, G., Martin, B. A., . . . Rosenthal, E. L. (2021). Intraoperative Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma. Laryngoscope, 131(3), 529-534.
DOI Scopus9 WoS8 Europe PMC4
2021 Pei, J., Juniper, G., van den Berg, N. S., Nisho, N., Broadt, T., Welch, A. R., . . . Rosenthal, E. L. (2021). Safety and Stability of Antibody-Dye Conjugate in Optical Molecular Imaging. Molecular Imaging and Biology, 23(1), 109-116.
DOI Scopus5 Europe PMC7
2021 Kapoor, S., Lu, G., van den Berg, N. S., Krishnan, G., Pei, J., Zhou, Q., . . . Nishio, N. (2021). Effect of Formalin Fixation for Near-Infrared Fluorescence Imaging with an Antibody-Dye Conjugate in Head and Neck Cancer Patients. Molecular Imaging and Biology, 23(2), 270-276.
DOI Scopus2 Europe PMC3
2021 Krishnan, G., van den Berg, N. S., Nishio, N., Juniper, G., Pei, J., Zhou, Q., . . . Rosenthal, E. L. (2021). Metastatic and sentinel lymph node mapping using intravenously delivered Panitumumab-IRDye800CW. Theranostics, 11(15), 7188-7198.
DOI Scopus9 Europe PMC2
2020 Hart, Z. P., Nishio, N., Krishnan, G., Lu, G., Zhou, Q., Fakurnejad, S., . . . Baik, F. M. (2020). Endoscopic fluorescence-guided surgery for sinonasal cancer using an antibody-dye conjugate. Laryngoscope, 130(12), 2811-2817.
DOI Scopus9 WoS9 Europe PMC3
2020 Fakurnejad, S., Krishnan, G., van Keulen, S., Nishio, N., Birkeland, A. C., Baik, F. M., . . . Martin, B. A. (2020). Intraoperative Molecular Imaging for ex vivo Assessment of Peripheral Margins in Oral Squamous Cell Carcinoma. Frontiers in Oncology, 9, 7 pages.
2019 Krishnan, G., Mintz, J., Foreman, A., Hodge, J., & Krishnan, S. (2019). The acceptance and adoption of transoral robotic surgery in Australia and New Zealand. Journal of Robotic Surgery, 13(2), 301-307.
DOI Scopus10 WoS8 Europe PMC4
2019 Krishnan, G., Stepan, L., Du, C., Padhye, V., Bassiouni, A., Dharmawardana, N., . . . Krishnan, S. (2019). Tonsillectomy using the BiZact: A pilot study in 186 children and adults. Clinical Otolaryngology, OnlinePubl(3), 4 pages.
DOI Scopus7 WoS6 Europe PMC3
2018 Krishnan, G. (2018). Evolution of neck dissections performed in conjunction with transoral robotic surgery lateral oropharyngectomy. Australian Journal of Otolaryngology, 1(1), 6.
2017 Krishnan, G., Du, C., Fishman, J., Foreman, A., Lott, D., Farwell, G., . . . Birchall, M. (2017). The current status of human laryngeal transplantation in 2017: A state of the field review. Laryngoscope, 127(8), 1861-1868.
DOI Scopus12 WoS12 Europe PMC5
2017 Krishnan, G., & Krishnan, S. (2017). Transoral Robotic Surgery Total Laryngectomy: Evaluation of Functional and Survival Outcomes in a Retrospective Case Series at a Single Institution. ORL, 79(4), 191-201.
DOI Scopus20 WoS19 Europe PMC8
2016 Kao, S. S. T., Peters, M. D. J., Krishnan, S. G., & Ooi, E. H. (2016). Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: A systematic review. Laryngoscope, 126(7), 1572-1580.
DOI Scopus29 WoS24 Europe PMC9
2016 Krishnan, S., Umapathysivam, K., Lockwood, C., & Hodge, J. (2016). Oncological and survival outcomes following transoral robotic surgery versus transoral laser microsurgery for the treatment of oropharyngeal squamous cell carcinoma: a systematic review protocol. JBI database of systematic reviews and implementation reports, 14(8), 90-102.
DOI Scopus2 Europe PMC1
|2018||1||The Fulbright Post-Graduate Scholarship||$35,000|
|2018||3||The Garnett Passe and Rodney William’s Foundation Academic Surgeon Scientist Scholarship||$210,000|
|2018||3||The Garnett Passe and Rodney Williams Memorial Foundation Conjoint Grant||$300,000|
|2018||1||The Australia and New Zealand Head and Neck Cancer Society (ANZHNCS) Research Grant||$5,000|
|2017||1||AVANT Doctors in training Advancement of Medicine Scholarship||$50,000|
|2017||1||The University of Adelaide, Faculty of Health Sciences Divisional Scholarship||$26,000|
|2012||6 wks||The University of Adelaide Summer Research Scholarship||$500|
Giri is a Clinical Associate Lecturer at the University of Adelaide. He has been involved in teaching a variety of courses and has also be an oral assessor for entry into the medical program as well as an examiner for the medical student clinical examinations.
|Year||Course Title||Institution||School / Department|
|2018||Applied Clinical Anatomy||University of Adelaide||Health Sciences|
|2017||Case Based Collaborative Learning||University of Adelaide||Medicine|
|2016||Suturing Tutorials||The Royal Adelaide Hospital||Surgery|
|2015||Introduction to ENT Course for Interns and Residents||The Royal Adelaide Hospital||Otolaryngology, Head and Neck Surgery|
|2014||Bedside Tutorials||The Royal Adelaide Hospital||Medical Education|
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Co-Supervisor Recurrence and complications in transoral robotic surgery patients compared to patients treated with chemoradiotherapy. Master of Clinical Science Master Full Time Miss Bola Jeong 2021 Co-Supervisor What is the effectiveness of reduced dose versus standard dose radiotherapy on survival and radiation associated toxicity in patients with newly diagnosed HPV associated oropharyngeal squamous cell carcinoma: a systematic review Master of Clinical Science Master Full Time Mr Timothy James Lee
Date Role Membership Country 2018 - ongoing Member Australian Society of Otolaryngology Head and Neck Surgery Australia 2018 - ongoing Member Royal Australian College of Surgeons Australia 2017 - ongoing Member Australia and New Zealand Head and Neck Society Australia 2016 - ongoing Board Member DREAMIN Foundation Incorporated - 2015 - 2016 President The Royal Adelaide Hospital Resident Medical Officers' Society Australia
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