Genevieve Secker

Dr Genevieve Secker

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.


Year Citation
2026 Wiszniak, S., Alankarage, D., Lohraseb, I., Marchant, C., Secker, G., Domingo, D., . . . Schwarz, Q. (2026). Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development.. Nature Communications, 17(1), 17511-1751-17.
DOI
2023 Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G. A., . . . Cox, C. D. (2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381(6659), 799-804.
DOI Scopus65 WoS65 Europe PMC72
2022 Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15.
DOI Scopus42 WoS35 Europe PMC34
2022 Lohraseb, I., McCarthy, P., Secker, G., Marchant, C., Wu, J., Ali, N., . . . Schwarz, Q. (2022). Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells. Nature Communications, 13(1), 1-18.
DOI Scopus10 WoS12 Europe PMC12
2021 Secker, G. A., & Harvey, N. L. (2021). Regulation of vegfr signalling in lymphatic vascular development and disease: an update. International Journal of Molecular Sciences, 22(14), 1-16.
DOI Scopus61 WoS53 Europe PMC44
2020 Betterman, K. L., Sutton, D. L., Secker, G. A., Kazenwadel, J., Oszmiana, A., Lim, L., . . . Harvey, N. L. (2020). Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Journal of Clinical Investigation, 130(6), 3315-3328.
DOI Scopus56 WoS52 Europe PMC51
2019 Baek, S., Oh, T. G., Secker, G., Sutton, D. L., Okuda, K. S., Paterson, S., . . . Hogan, B. M. (2019). The alternative splicing regulator Nova2 constrains vascular Erk signaling to limit specification of the lymphatic lineage. Developmental Cell, 49(2), 279-292.e5.
DOI Scopus31 WoS30 Europe PMC33
2017 Lumb, R., Buckberry, S., Secker, G., Lawrence, D., & Schwarz, Q. (2017). Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels. BMC Developmental Biology, 17(1), 5-1-5-12.
DOI Scopus20 WoS20 Europe PMC21
2015 Secker, G. A., & Harvey, N. L. (2015). VEGFR signaling during lymphatic vascular development : from progenitor cells to functional vessels. Developmental Dynamics, 244(3), 323-331.
DOI Scopus102 WoS96 Europe PMC88
2015 Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994.
DOI Scopus201 WoS185 Europe PMC173
2014 Bowles, J., Secker, G., Nguyen, C., Kazenwadel, J., Truong, V., Frampton, E., . . . Francois, M. (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386(1), 25-33.
DOI Scopus39 WoS34 Europe PMC37
2014 Shortt, A. J., Bunce, C., Levis, H. J., Blows, P., Doŕe, C. J., Vernon, A., . . . Daniels, J. T. (2014). Three-year outcomes of cultured limbal epithelial allografts in aniridia and stevens-johnson syndrome evaluated using the clinical outcome assessment in surgical trials assessment tool. Stem Cells Translational Medicine, 3(2), 265-275.
DOI Scopus92 WoS86 Europe PMC77
2013 Wiszniak, S., Kabbara, S., Lumb, R., Scherer, M., Secker, G., Harvey, N., . . . Schwarz, Q. (2013). The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Developmental Biology, 383(2), 186-200.
DOI Scopus28 WoS30 Europe PMC30
2012 Kazenwadel, J., Secker, G., Betterman, K., & Harvey, N. (2012). In Vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis. PLoS One, 7(7), 1-12.
DOI Scopus38 WoS35 Europe PMC38
2012 Francois, M., Short, K., Secker, G., Combes, A., Schwarz, Q., Davidson, T., . . . Koopman, P. (2012). Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Developmental Biology, 364(2), 89-98.
DOI Scopus76 WoS73 Europe PMC63
2012 Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291.
DOI Scopus252 WoS219 Europe PMC209
2012 Radhakrishnan, S. S., Blalock, T. D., Robinson, P. M., Secker, G., Daniels, J., Grotendorst, G. R., & Schultz, G. S. (2012). Effect of connective tissue growth factor on protein kinase expression and activity in human corneal fibroblasts.. Investigative ophthalmology & visual science, 53(13), 8076-8085.
DOI Scopus17 WoS14 Europe PMC14
2009 Shortt, A. J., Secker, G. A., Lomas, R. J., Wilshaw, S. P., Kearney, J. N., Tuft, S. J., & Daniels, J. T. (2009). The effect of amniotic membrane preparation method on its ability to serve as a substrate for the ex-vivo expansion of limbal epithelial cells. Biomaterials, 30(6), 1056-1065.
DOI Scopus115 WoS101 Europe PMC85
2008 Secker, G. A., Shortt, A., Sampson, E., Schwarz, Q. P., & Daniels, J. (2008). TGFBeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling. Experimental cell research, 314(1), 131-142.
DOI Scopus88 WoS81 Europe PMC75
2008 Shortt, A., Secker, G. A., Rajan, M., Meligonis, G., Dart, J., Tuft, S., & Daniels, J. (2008). Ex vivo expansion and transplantation of limbal epithelial stem cells. Ophthalmology, 115(11), 1989-1997.
DOI Scopus158 WoS143 Europe PMC124
2008 Secker, G. A., & Daniels, J. (2008). Corneal epithelial stem cells : deficiency and regulation. Stem cell reviews, 4(3), 159-168.
DOI Scopus56 WoS46 Europe PMC43
2008 Watson, S., Secker, G. A., & Daniels, J. (2008). The effect of therapeutic human serum drops on corneal stromal wound-healing activity. Current Eye Research, 33(8), 641-652.
DOI Scopus18 WoS16 Europe PMC11
2007 Shortt, A. J., Secker, G. A., Notara, M. D., Limb, G. A., Khaw, P. T., Tuft, S. J., & Daniels, J. T. (2007). Transplantation of Ex Vivo Cultured Limbal Epithelial Stem Cells: A Review of Techniques and Clinical Results. Survey of Ophthalmology, 52(5), 483-502.
DOI Scopus307 WoS263 Europe PMC215
2007 Shortt, A. J., Secker, G. A., Munro, P. M., Khaw, P. T., Tuft, S. J., & Daniels, J. T. (2007). Characterization of the limbal epithelial stem cell niche: Novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells. Stem Cells, 25(6), 1402-1409.
DOI Scopus285 WoS262 Europe PMC219
2007 Daniels, J. T., Notara, M., Shortt, A. J., Secker, G., Harris, A., & Tuft, S. J. (2007). Limbal epithelial stem cell therapy. Expert Opinion on Biological Therapy, 7(1), 1-3.
DOI Scopus32 WoS26 Europe PMC21
2006 Daniels, J. T., Secker, G. A., Shortt, A. J., Tuft, S. J., & Seetharaman, S. (2006). Stem cell therapy delivery: treading the regulatory tightrope.. Regenerative Medicine, 1(5), 715-719.
DOI Scopus35 WoS27 Europe PMC24
2006 Limb, G. A., Daniels, J. T., Cambrey, A. D., Secker, G. A., Shortt, A. J., Lawrence, J. M., & Khaw, P. T. (2006). Current prospects for adult stem cell-based therapies in ocular repair and regeneration. Current Eye Research, 31(5), 381-390.
DOI Scopus36 WoS32 Europe PMC20
2002 Kochetkova, M., McKenzie, O., Bais, A., Martin, J., Secker, G., Seshadri, R., . . . Callen, D. (2002). CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. Cancer Research, 62(16), 4599-4604.
Scopus62 WoS61 Europe PMC52

Year Citation
2010 Daniels, J., Secker, G. A., & Shortt, A. (2010). Ocular surface restoration. In L. Levin, & D. Albert (Eds.), Source details - Title: Ocular Disease: Mechanisms and Management (pp. 83-90). US: Elsevier.
DOI
2010 Daniels, J. T., Secker, G. A., & Shortt, A. J. (2010). Ocular surface restoration. In Ocular Disease Mechanisms and Management Expert Consult (pp. 83-90).
DOI

Year Citation
2025 Wiszniak, S., Alankarage, D., Lohraseb, I., Marchant, C., Secker, G., Parker, W., . . . Schwarz, Q. (2025). Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development.
DOI

Courses I teach

  • BIOL 2036 Histology (2024)

Date Role Research Topic Program Degree Type Student Load Student Name
2023 Co-Supervisor Understanding the genetic and developmental basis of human lymphatic vascular disease Doctor of Philosophy Doctorate Full Time Miss Ushani Mallawa Arachchige

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