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Professor Frank Grutzner

Frank Grutzner
Genetics Lecturer
School of Biological Sciences
Faculty of Sciences

Professor Frank Grützner received his PhD at the Max Planck Institute for Molecular Genetics, Berlin in 2001. In the same year he moved to the Australian National University where he led and international team that resolved the longstanding controversy about the complex sex chromosome system in the platypus. In 2005 he moved to the University of Adelaide, where he is an ARC Australian Research Fellow and group leader at the School of Biological Sciences. Dr Grutzner has worked in the field of comparative genome biology in many different species and published extensively in leading international journals including Nature, Nature Genetics and Science. For the past 10 years he has been instrumental in establishing monotremes as evolutionary model for research in comparative genomics.

He has won several awards for his research including the Eppendorf Medal for the Young Australian Investigator (2005) and the Tall Poppy Science Award (2007/8). His research has been supported by competitive ARC research fellowships and grants since 2003. Dr Grutzner is an associate editor for BMC Genomics and has served on NHMRC grant review panels. He is currently a member of the ARC college of experts.

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Professor Frank Grutzner

Professor Frank Grützner received his PhD at the Max Planck Institute for Molecular Genetics, Berlin in 2001. In the same year he moved to the Australian National University where he led and international team that resolved the longstanding controversy about the complex sex chromosome system in the platypus. In 2005 he moved to the University of Adelaide, where he is an ARC Australian Research Fellow and group leader at the School of Biological Sciences. Dr Grutzner has worked in the field of comparative genome biology in many different species and published extensively in leading international journals including Nature, Nature Genetics and Science. For the past 10 years he has been instrumental in establishing monotremes as evolutionary model for research in comparative genomics.

He has won several awards for his research including the Eppendorf Medal for the Young Australian Investigator (2005) and the Tall Poppy Science Award (2007/8). His research has been supported by competitive ARC research fellowships and grants since 2003. Dr Grutzner is an associate editor for BMC Genomics and has served on NHMRC grant review panels. He is currently a member of the ARC college of experts.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Comparative Genome Biology

Our research aims to understand how different animal genomes evolved, how they are organised and how this effects their function. We use our results to better understand genome evolution and function but also to apply our novel insights to human disease and animal conservation. Our main species of interest are the iconic egg-laying mammals, the duck-billed platypus and short-beaked echidna. As the oldest surviving mammalian lineage these extraordinary animals provide valuable insights into mammalian evolution and human disease.

current research areas:

Sex chromosome evolution and function in mammals

Evolution and function of genes involved in metabolic control

Evolution of monoallelic gene expression and genomic imprinting

Evolution of non coding RNAs in reproduction

Function of the piRNA pathway in ovarian cancer

Application and development of moelcuar tools to aid monotreme field biolgy, conservation and captive breeding

Investigating mosquitofish sex determination as a tool for pest animal control

 

The Monotreme Resource Centre

Egg-laying mammals feature extraordinary biology and are the oldest surviving mammal. Platypus and echidna caputure the interest of researchers worl wide ever since the first specimen were send to England in 1798. Access to material from these animals has always been the limiting factor for research to better understand the biology of these animals. Since 2001 we have assembled a world-wide unique collection of well over 1000 specimen of tissues from platypus and echidna which are availbale for research. This has resulted in breakthrough research including monotremes and new datasets that are available to the research community to use to better understand mammalian evolution. Please contact us for more information about the collection and collaborative opportunities.

Appointments

Date Position Institution name
2013 Professor (ARC fellow) The University of Adelaide
2005 ARC research fellow The University of Adelaide
2001 - 2004 Researcher Australian National University
1997 - 2016 PhD candidate Max Planck Institute of Molecular Genetics

Awards and Achievements

Date Type Title Institution Name Country Amount
2011 Award ARC Fellowship (ARF) Australian Research Council Australia
2010 Achievement Finalist: Scopus Award for the Young Australian Researcher (Biological Sciences) Australia
2008 Award Research Career Development ECR Achievement award (School of Molecular and Biomedical Science) The University of Adelaide Australia
2008 Award Certificate of merit for research excellence, Faculty of Science, University of Adelaide The University of Adelaide Australia
2007 Award Tall Poppy Science Award Australian Institute of Policy and Science Australia
2006 Award ARC Fellowship (ARF) Australian Research Council Australia
2005 Award Eppendorf Medal for the Young Australian Investigator Eppendorf Australia

Journals

Year Citation
2018 Gautier, C., Guenin, S., Riest-Fery, I., Perry, T., Legros, C., Nosjean, O., . . . Boutin, J. (2018). Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). PLoS ONE, 13(3), e0191904-1-e0191904-20.
DOI
2018 Martin, H. C., Batty, E. M., Hussin, J., Westall, P., Daish, T., Kolomyjec, S., . . . Donnelly, P. (2018). Insights into Platypus Population Structure and History from Whole-Genome Sequencing. MOLECULAR BIOLOGY AND EVOLUTION, 35(5), 1238-1252.
DOI WoS1 Europe PMC1
2017 Estrella, C., Kind, K., Derks, A., Xiang, R., Faulkner, N., Mohrdick, M., . . . Hiendleder, S. (2017). Remodelling of the bovine placenta: Comprehensive morphological and histomorphological characterization at the late embryonic and early accelerated fetal growth stages. Placenta, 55, 37-46.
DOI
2017 Adikusuma, F., Williams, N., Grutzner, F., Hughes, J., & Thomas, P. (2017). Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9. Molecular Therapy, 25(8), 1736-1738.
DOI Scopus2 WoS2 Europe PMC3
2017 Casey, A., Daish, T., Barbero, J., & Grützner, F. (2017). Differential cohesin loading marks paired and unpaired regions of platypus sex chromosomes at prophase i. Scientific Reports, 7(1), 4217-1-4217-14.
DOI
2016 Tsend-Ayush, E., He, C., Myers, M., Andrikopoulos, S., Wong, N., Sexton, P., . . . Grutzner, F. (2016). Monotreme glucagon-like peptide-1 in venom and gut: One gene - Two very different functions. Scientific Reports, 6(1), 12 pages.
DOI Scopus3 WoS3 Europe PMC2
2015 Lynch, V., Nnamani, M., Kapusta, A., Brayer, K., Plaza, S., Mazur, E., . . . Wagner, G. (2015). Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy. Cell Reports, 10(4), 551-561.
DOI Scopus67 WoS63 Europe PMC55
2015 He, C., Myers, M., Forbes, B., & Grützner, F. (2015). Immunohistochemical analysis of pancreatic islets of platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus ssp.). Journal of Anatomy, 226(4), 373-380.
DOI Scopus3 WoS3 Europe PMC2
2015 Casey, A., Daish, T., & Grutzner, F. (2015). Identification and characterisation of synaptonemal complex genes in monotremes. Gene, 567(2), 146-153.
DOI Scopus3 WoS3 Europe PMC3
2015 Daish, T., Casey, A., & Grutzner, F. (2015). Lack of sex chromosome specific meiotic silencing in platypus reveals origin of MSCI in therian mammals. BMC Biology, 13(1), 106-1-106-13.
DOI Scopus5 WoS5 Europe PMC5
2014 Necsulea, A., Soumillon, M., Warnefors, M., Liechti, A., Daish, T., Zeller, U., . . . Kaessmann, H. (2014). The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature, 505(7485), 635-640.
DOI Scopus327 WoS315 Europe PMC273
2014 Lim, S., Ricciardelli, C., Oehler, M., De Arao Tan, I., Russell, D., & Grützner, F. (2014). Overexpression of piRNA pathway genes in epithelial ovarian cancer. PLoS One, 9(6), e99687-1-e99687-11.
DOI Scopus24 WoS24 Europe PMC17
2014 Cortez, D., Marin, R., Toledo-Flores, D., Froidevaux, L., Liechti, A., Waters, P., . . . Kaessmann, H. (2014). Origins and functional evolution of Y chromosomes across mammals. Nature, 508(7497), 488-493.
DOI Scopus125 WoS123 Europe PMC120
2013 Ayers, K., Davidson, N., Demiyah, D., Roeszler, K., Grutzner, F., Sinclair, A., . . . Smith, C. (2013). RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome. Genome Biology (Print): biology for the post-genomic era, 14(3), 16 pages.
DOI Scopus43 WoS37 Europe PMC30
2013 Lim, S., Tsend-Ayush, E., Kortschak, R., Jacob, R., Ricciardelli, C., Oehler, M., & Grutzner, F. (2013). Conservation and expression of piRNA pathway genes in male and female adult gonad of amniotes. Biology of Reproduction, 89(6), 1-13.
DOI Scopus12 WoS12 Europe PMC7
2013 He, C., Tsend-Ayush, E., Myers, M., Forbes, B., & Grutzner, F. (2013). Changes in the ghrelin hormone pathway maybe part of an unusual gastric system in monotremes. General and Comparative Endocrinology, 191, 74-82.
DOI Scopus6 WoS6 Europe PMC4
2013 Long, H., Sims, D., Heger, A., Blackledge, N., Kutter, C., Wright, M., . . . Klose, R. (2013). Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. eLife, 2013(2), e00348-1-e00348-19.
DOI Scopus84 WoS85 Europe PMC71
2013 Chang, C., Semyonov, J., Cheng, P., Huang, S., Park, J., Tsai, H., . . . Hsu, S. (2013). Widespread divergence of the CEACAM/PSG genes in vertebrates and humans suggests sensitivity to selection. PLoS One, 8(4), 1-13.
DOI Scopus9 WoS7 Europe PMC4
2013 Zemann, A., Churakov, G., Donnellan, S., Grutzner, F., Zhao, F., Brosius, J., & Schmitz, J. (2013). Ancestry of the Australian termitivorous numbat. Molecular Biology and Evolution, 30(5), 1041-1045.
DOI Scopus6 WoS4 Europe PMC5
2012 Williams, C., Hoppe, H., Rezgui, D., Strickland, M., Forbes, B., Grutzner, F., . . . Hassan, A. (2012). An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science, 338(6111), 1209-1213.
DOI Scopus18 WoS18 Europe PMC15
2012 Hrdlickova, R., Nehyba, J., Lim, S., Grutzner, F., & Bose, H. (2012). Insights into the evolution of mammalian telomerase: Platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes. BMC Genomics, 13(1), 2-38.
DOI Scopus5 WoS5 Europe PMC4
2012 Julien, P., Brawand, D., Soumillon, M., Necsulea, A., Liechti, A., Schutz, F., . . . Kaessmann, H. (2012). Mechanisms and evolutionary patterns of mammalian and avian dosage compensation. PLoS Biology, 10(5), 1-20.
DOI Scopus78 WoS77 Europe PMC74
2012 Tsend-Ayush, E., Kortschak, R., Bernard, P., Lim, S., Ryan, J., Rosenkranz, R., . . . Grutzner, F. (2012). Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes?. Chromosome Research, 20(1), 127-138.
DOI Scopus5 WoS5 Europe PMC4
2011 Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csardi, G., Harrigan, P., . . . Kaessmann, H. (2011). The evolution of gene expression levels in mammalian organs. Nature, 478(7369), 343-350.
DOI Scopus471 WoS461 Europe PMC435
2009 Ho, K., Deakin, J., Wright, M., Marshall Graves, J., & Grutzner, F. (2009). Replication asynchrony and differential condensation of X chromosomes in female platypus (Ornithorhynchus anatinus). Reproduction Fertility and Development, 21(8), 952-963.
DOI Scopus7 WoS7 Europe PMC2
2009 Daish, T., Casey, A., & Grutzner, F. (2009). Platypus chain reaction: directional and ordered meiotic pairing of the multiple sex chromosome chain in Ornithorhynchus anatinus. Reproduction Fertility and Development, 21(8), 976-984.
DOI Scopus7 WoS6 Europe PMC3
2009 Tsend-Ayush, E., Lim, S., Pask, A., Mohd Hamdan, D., Renfree, M., & Grutzner, F. (2009). Characterisation of ATRX, DMRT1, DMRT7 and WT1 in the platypus (Ornithorhynchus anatinus). Reproduction Fertility and Development, 21(8), 985-991.
DOI Scopus5 WoS5 Europe PMC2
2009 Kortschak, R., Tsend-Ayush, E., & Grutzner, F. (2009). Analysis of SINE and LINE repeat content of Y chromosomes in the platypus, Ornithorhynchus anatinus. Reproduction Fertility and Development, 21(8), 964-975.
DOI Scopus6 WoS6 Europe PMC5
2009 Warren, W., & Grutzner, F. (2009). The enigma of the platypus genome. Australian Journal of Zoology, 57(3-4), 157-165.
DOI Scopus3 WoS3
2009 Ivell, R., & Grutzner, F. (2009). Evolution and Male Fertility: Lessons from the Insulin-Like Factor 6 Gene (Insl6). Endocrinology, 150(9), 3986-3990.
DOI Scopus7 WoS7 Europe PMC7
2009 Daish, T., & Grutzner, F. (2009). Location, Location, Location! Monotremes Provide Unique Insights into the Evolution of Sex Chromosome Silencing in Mammals. DNA and Cell Biology, 28(2), 91-100.
DOI Scopus8 WoS8 Europe PMC5
2009 Tsend-Ayush, E., Dodge, N., Mohr, J., Casey, A., Himmelbauer, H., Kremitzki, C., . . . Grutzner, F. (2009). Higher-order genome organization in platypus and chicken sperm and repositioning of sex chromosomes during mammalian evolution. Chromosoma, 118(1), 53-69.
DOI Scopus14 WoS12 Europe PMC10
2008 Niwa, H., Sekita, Y., Tsend-Ayush, E., & Grutzner, F. (2008). Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals. Evolution & Development, 10(6), 671-682.
DOI Scopus46 WoS42 Europe PMC33
2008 Grutzner, F., Nixon, B., & Jones, R. (2008). Reproductive biology in egg-laying mammals. Sexual Development, 2(3), 115-127.
DOI Scopus12 WoS11 Europe PMC7
2008 Wakefield, M., Anderson, M., Chang, E., Wei, K., Kaul, R., Marshall-Graves, J., . . . Deeb, S. (2008). Cone visual pigments of monotremes: Filling the phylogenetic gap. Visual Neuroscience, 25(3), 257-264.
DOI Scopus32 WoS31 Europe PMC21
2008 Ordonez, G., Hillier, L., Warren, W., Grutzner, F., Lopez-Otin, C., & Puente, X. (2008). Loss of genes implicated in gastric function during platypus evolution. Genome Biology (Online Edition), 9(5), R81-1-R81-11.
DOI Scopus31 WoS28 Europe PMC21
2008 Schmitz, J., Zemann, A., Churakov, G., Kuhl, H., Grutzner, F., Reinhardt, R., & Brosius, J. (2008). Retroposed SNOfall - A mammalian-wide comparison of platypus snoRNAs. Genome Research, 18(6), 1005-1010.
DOI Scopus41 WoS39 Europe PMC36
2008 Murchison, E., Kheradpour, P., Sachidanandam, R., Smith, C., Hodges, E., Xuan, Z., . . . Hannon, G. (2008). Conservation of small RNA pathways in platypus. Genome Research, 18(6), 995-1004.
DOI Scopus26 WoS23 Europe PMC19
2008 Veyrunes, F., Waters, P., Miethke, P., Rens, W., McMillan, D., Alsop, A., . . . Graves, J. (2008). Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes. Genome Research, 18(6), 965-973.
DOI Scopus191 Europe PMC150
2008 Warren, W., Hillier, L., Graves, J., Birney, E., Ponting, C., Grutzner, F., . . . Wilson, R. (2008). Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453(7192), 175-184.
DOI Scopus439 WoS427 Europe PMC334
2008 Warren, W., Hillier, L., Marshall Graves, J., Birney, E., Ponting, C., Grützner, F., . . . Nefedov, M. (2008). Genome analysis of the platypus reveals unique signatures of evolution (Nature (2008) 453, (175-183)). Nature, 455(7210), 256.
DOI Scopus6 WoS7
2007 Wallis, M., Delbridge, M., Pask, A., Alsop, A., Grutzner, F., O'Brien, P., . . . Graves, J. (2007). Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role. Cytogenetic and Genome Research, 116(3), 232-234.
DOI Scopus13 WoS9 Europe PMC9
2007 El-Mogharbel, N., Wakefield, M., Deakin, J., Tsend-Ayush, E., Grutzner, F., Alsop, A., . . . Graves, J. (2007). DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions. Genomics, 89(1), 10-21.
DOI Scopus31 WoS30 Europe PMC22
2007 Wallis, M., Waters, P., Delbridge, M., Kirby, P., Pask, A., Grutzner, F., . . . Graves, J. (2007). Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes. Chromosome Research, 15(8), 949-959.
DOI Scopus43 WoS43 Europe PMC27
2007 Dohm, J., Tsend-Ayush, E., Reinhardt, R., Grutzner, F., & Himmelbauer, H. (2007). Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes. Genome Biology (Online Edition), 8(8), R175-1-R175-16.
DOI Scopus27 WoS26 Europe PMC18
2007 McMillan, D., Miethke, P., Alsop, A., Rens, W., O'Brien, P., Trifonov, V., . . . Graves, J. (2007). Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus). Chromosome Research, 15(8), 961-974.
DOI Scopus11 WoS10 Europe PMC9
2007 Rens, W., O'Brien, P., Grutzner, F., Clarke, O., Graphodatskaya, D., Tsend-Ayush, E., . . . Ferguson-Smith, M. (2007). The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z. Genome Biology (Online Edition), 8(11), R243:1-R243:21.
DOI Scopus77 WoS67 Europe PMC57
2006 Delbridge, M., Wallis, M., Kirby, P., Alsop, A., Grutzner, F., & Graves, J. (2006). Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization. Cytogenetic and Genome Research, 112(3-4), 342L-1-342L-2.
DOI Scopus3 WoS3 Europe PMC3
2006 Ezaz, T., Valenzuela, N., Grutzner, F., Miura, I., Georges, A., Burke, R., & Graves, J. (2006). An XX/XY sex microchromosome system in a freshwater turtle, Chelodina longicollis (Testudines: Chelidae) with genetic sex determination. Chromosome Research, 14(2), 139-150.
DOI Scopus45 WoS46 Europe PMC26
2006 Yue, Y., Tsend-Ayush, E., Grutzner, F., Grossmann, B., & Haaf, T. (2006). Segmental duplication associated with evolutionary instability of human chromosome 3p25. Cytogenetic and Genome Research, 112(3-4), 202-207.
DOI Scopus4 WoS3 Europe PMC4
2006 Sankovic, N., Delbridge, M., Grutzner, F., Ferguson-Smith, M., O'Brien, P., & Graves, J. (2006). Construction of a highly enriched marsupial Y chromosome-specific BAC sub-library using isolated Y chromosomes. Chromosome Research, 14(6), 657-664.
DOI Scopus15 WoS15 Europe PMC11
2006 Grutzner, F., Ashley, T., Rowell, D., & Graves, J. (2006). How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals. Chromosoma, 115(2), 75-88.
DOI Scopus34 WoS20 Europe PMC28
2005 Tsend-Ayush, E., O'Sullivan, L., Grutzner, F., Onnebo, S., Lewis, R., Dellbridge, M., . . . Ward, A. (2005). RBMX gene is essential for brain development in zebrafish. Developmental Dynamics, 234(3), 682-688.
DOI Scopus21 Europe PMC16
2005 Yue, Y., Grossmann, B., Tsend-Ayush, E., Grutzner, F., Ferguson-Smith, M., Yang, F., & Haaf, T. (2005). Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2. Cytogenetic and Genome Research, 108(1-3), 98-105.
DOI Scopus9 WoS9 Europe PMC8
2004 Grutzner, F., Rens, W., Tsend-Ayush, E., El-Mogharbel, N., O'Brien, P., Jones, R., . . . Graves, J. (2004). In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes. Nature, 432(7019), 913-917.
DOI Scopus184 WoS177 Europe PMC123
2004 Rens, W., Grutzner, F., O'Brien, P., Fairclough, H., Graves, J., & Ferguson-Smith, M. (2004). Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. Proceedings of the National Academy of Sciences of the United States of America, 101(46), 16257-16261.
DOI Scopus110 WoS105 Europe PMC71
2004 Grutzner, F., & Graves, J. (2004). A platypus’ eye view of the mammalian genome. Current Opinion in Genetics & Development, 14(6), 642-649.
DOI Scopus25 WoS24 Europe PMC18
2004 Tsend-Ayush, E., Grutzner, F., Grossmann, B., Hansel, U., Sudbrak, R., & Haaf, T. (2004). Plasticity of human chromosome 3 during primate evolution. Genomics, 83(2), 193-202.
DOI Scopus21 WoS20 Europe PMC18
2003 Chapman, M., Charchar, F., Kinston, S., Bird, C., Grafham, D., Rogers, J., . . . Gottgens, B. (2003). Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting. Genomics, 81(3), 249-259.
DOI Scopus32 WoS29 Europe PMC24
2003 Santucciu, C., Grutzner, F., Carvalho-Silva, D., & Graves, J. (2003). Isolation of chromosomal regions controlling intersex development in a marsupial. Cytogenetic and Genome Research, 101(3-4), 224-228.
DOI Scopus4 WoS3 Europe PMC2
2003 Grutzner, F., Deakin, J., Rens, W., El-Mogharbel, N., & Marshall Graves, J. (2003). The monotreme genome: a patchwork of reptile mammal and unique features?. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 136(4), 867-881.
DOI Scopus31 WoS29 Europe PMC15
2002 Smith, S., Snell, P., Grutzner, F., Bench, A., Haaf, T., Metcalfe, J., . . . Elgar, G. (2002). Analyses of the extent of shared synteny and conserved gene orders between the genome of fugu rubripes and human 20q. Genome Research, 12(5), 776-784.
DOI Scopus44 WoS40 Europe PMC28
2002 Grutzner, F., Crollius, H., Lutjens, G., Weissenbach, J., Ropers, H., & Haaf, T. (2002). Four-Hundred Million Years of Conserved Synteny of Human Xp and Xq Genes on Three Tetraodon Chromosomes. Genome Research, 12(9), 1316-1322.
DOI Scopus23 WoS21 Europe PMC15
2001 Grutzner, F., Tsend-Ayush, E., Stout, K., Munsche, S., Niveleau, A., Nanda, I., . . . Haaf, T. (2001). Chicken microchromosomes are hypermethylated and can be identified by specific painting probes. Cytogenetic and Genome Research, 93(3-4), 265-269.
DOI Scopus23 WoS22 Europe PMC8
2001 Bouchireb, N., Grutzner, F., Haaf, T., Stephens, R., Elgar, G., Green, A., & Clark, M. (2001). Comparative mapping of the human 9q34 region in Fugu rubripes. Cytogenetic and Genome Research, 94(3-4), 173-179.
DOI Scopus6 WoS5 Europe PMC2
2001 Toder, R., Grutzner, F., Haaf, T., & Bausch, E. (2001). Species-specific evolution of repeated DNA sequences in great apes. Chromosome Research, 9(6), 431-435.
DOI Scopus4 WoS5 Europe PMC2
2001 Zimdahl, H., Gosele, C., Lutjens, G., Grutzner, F., Kreitler, T., Voss, K., . . . Knoblauch, M. (2001). Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization. Cytogenetic and Genome Research, 94(1-2), 101-104.
DOI
2001 Zend-Ajusch, E., Gruetzner, F., Haensel, U., Sudbrack, R., Ropers, H., & Haaf, T. (2001). A large intragenomic duplication homologous to human chromosome 3p21-24 during hominoid evolution.. AMERICAN JOURNAL OF HUMAN GENETICS, 69(4), 329.
2000 Haaf, T., Roest Crollius, H., Weissenbach, J., Lutjens, G., Brunner, B., Ropers, H., & Grutzner, F. (2000). Comparative gene and genome mapping in pufferfish and humans.. AMERICAN JOURNAL OF HUMAN GENETICS, 67(4), 23.
2000 Brunner, B., Grutzner, F., Yaspo, M., Ropers, H., Haaf, T., & Kalscheuer, V. (2000). Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis. Chromosome Research, 8(6), 465-476.
DOI Scopus12 WoS13 Europe PMC7
2000 Cai, L., Lindpaintner, K., Browne, J., Gruetzner, F., Haaf, T., James, M., & Bihoreau, M. (2000). An anchored YAC-STS framework for the rat genome. Cytogenetics and Cell Genetics, 89(3-4), 168-170.
DOI Scopus3 WoS1 Europe PMC1
2000 Nanda, I., Zend-Ajusch, E., Shan, Z., Grützner, F., Schartl, M., Burt, D., . . . Schmid, M. (2000). Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1: A comparative (re)view on avian sex determination. Cytogenetics and Cell Genetics, 89(1-2), 67-78.
DOI Scopus140 WoS133 Europe PMC70
2000 Gösele, C., Grützner, F., Pesquero, J., Silva, J., Junge, T., Ganten, D., . . . Knoblauch, M. (2000). Assignment of the kinin receptor B1 and B2 genes (Bdkrb1 and Bdkrb2) to rat chromosome 6q3.2 by FISH and radiation hybrid mapping. Cytogenetics and Cell Genetics, 89(1-2), 51-52.
DOI Scopus3 WoS3 Europe PMC3
1999 Grützner, F., Lütjens, G., Rovira, C., Barnes, D., Ropers, H., & Haaf, T. (1999). Classical and molecular cytogenetics of the pufferfish Tetraodon nigroviridis. Chromosome Research, 7(8), 655-662.
DOI Scopus24 WoS24 Europe PMC12
1999 Sharon, D., Glusman, G., Pilpel, Y., Khen, M., Gruetzner, F., Haaf, T., & Lancet, D. (1999). Primate evolution of an olfactory receptor cluster: Diversification by gene conversion and recent emergence of pseudogenes. Genomics, 61(1), 24-36.
DOI Scopus94 WoS91 Europe PMC66
1999 Roemer, I., Grutzner, F., Winking, H., Haaf, T., Orth, A., Skidmore, L., . . . Fundele, R. (1999). Genome evolution - Global methylation in eutherian hybrids. NATURE, 401(6749), 131-132.
DOI WoS19 Europe PMC64
1999 Nanda, I., Shan, Z., Schartl, M., Burt, D., Koehler, M., Nothwang, G., . . . Schmid, M. (1999). 300 million years of conserved synteny between chicken Z and human chromosome 9 [2]. Nature Genetics, 21(3), 258-259.
DOI Scopus255 WoS244 Europe PMC145
1999 Grützner, F., Himmelbauer, H., Paulsen, M., Hans-Ropers, H., & Haaf, T. (1999). Comparative mapping of mouse and rat chromosomes by fluorescence in situ hybridization. Genomics, 55(3), 306-313.
DOI Scopus36 WoS37 Europe PMC18
1999 Roemer, I., Grützner, F., Winking, H., Haaf, T., Orth, A., Skidmore, L., . . . Fundele, R. (1999). Global methylation in eutherian hybrids. Nature, 401(6749), 131-132.
DOI Scopus20
1999 Shan, Z., Zend-Ajusch, E., Gruetzner, F., & Haaf, T. (1999). Cytogenetic and molecular characterization of evolutionary chromosome breakpoints in great apes.. AMERICAN JOURNAL OF HUMAN GENETICS, 65(4), A357.
1999 Gruetzner, F., Roest-Crollius, H., Lutjens, G., Barnes, D., Ropers, H., Weissenbach, J., & Haaf, T. (1999). Comparative gene and genome mapping in Tetraodon nigroviridis and Fugu rubripes. CYTOGENETICS AND CELL GENETICS, 85(1-2), 32.
1998 Gläser, B., Grützner, F., Willmann, U., Stanyon, R., Arnold, N., Taylor, K., . . . Schempp, W. (1998). Simian Y Chromosomes: Species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY. Mammalian Genome, 9(3), 226-231.
DOI Scopus41 WoS39 Europe PMC18
1997 Gläser, B., Grützner, F., Taylor, K., Schiebel, K., Meroni, G., Tsioupra, K., . . . Schempp, W. (1997). Comparative mapping of Xp22 genes in hominoids - evolutionary linear instability of their Y homologues. Chromosome Research, 5(3), 167-176.
DOI Scopus24 WoS23 Europe PMC6
1993 Schempp, W., Toder, R., Rietschel, W., Grützner, F., Mayerová, A., & Gauckler, A. (1993). Inverted and satellited Y chromosome in the orangutan (Pongo pygmaeus). Chromosome Research, 1(1), 69-75.
DOI Scopus17 WoS18 Europe PMC11
Lynch, V. J., Nnamani, M., Brayer, K. J., Emera, D., Wertheim, J. O., Pond, S. L. K., . . . Wagner, G. P. (n.d.). Lineage-specific transposons drove massive gene expression recruitments
during the evolution of pregnancy in mammals.

Book Chapters

Conference Papers

Year Citation
2008 Grutzner, F. (2008). Evolution and organization of monotreme sex chromosomes. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 282-283). Kailua Kona, HI: SOC STUDY REPRODUCTION.
DOI
2007 Rens, W., O'Brien, P. C., Grutzner, F., Clarke, O., Graphodatskaya, D., Tsend-Ayush, E., . . . Ferguson-Smith, M. (2007). Characterization of the platypus and echidna sex chromosome system. In CHROMOSOME RESEARCH Vol. 15 (pp. 92). Amsterdam, NETHERLANDS: SPRINGER.
2007 Veyrunes, F., Rens, W., Waters, P., Miethke, P., Alsop, A., Grutzner, F., . . . Graves, J. (2007). Does the platypus sex chromosome system derive from an ancestral bird ZW system?. In CHROMOSOME RESEARCH Vol. 15 (pp. 72-73). Amsterdam, NETHERLANDS: SPRINGER.
2006 Grutzner, F. (2006). Sex Chromosomes Down Under: XY in platypus. In Molecular and Cellular Endocrinology 257¿258 (2006) 1¿5. Minutes of the 14th European Workshop on Molecular and Cellular Endocrinology of the Testis (pp. 1-5). Online.
2005 Grutzner, F., Rens, W., Tsend-Ayush, E., El-Mogharbel, N., O'Brien, P., Jones, R., . . . Graves, J. (2005). Evolution and organization of the ten sex chromosome system in platypus. In Proceedings of the Australian Society for Biochemistry and Molecular Biology ; v. 37. ComBio 2005 : combined conference abstracts, Adelaide Convention Centre, Adelaide,South Australia, 25 September to 29 Septembr 2005. Adelaide, South Australia.
2004 Grutzner, F., Rens, W., Jones, R., Tsend-Ayush, E., & Graves, J. (2004). Platypus have four male-specific chromosomes that segregate together at meiosis. In Human Genome Meeting (2004: Berlin, Germany). Berlin, Germany.

Conference Items

Resarch funding acknowledgements

Australian research council, Australian Geographic

I teach a substantial component of the thir year genetics course "Genes, Genomes and Molecular Evolution"

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Principal Supervisor Evolution of Metabolic Control in Mammals Doctor of Philosophy Doctorate Full Time Miss Natasha Paige Bradley
2018 Principal Supervisor The genetic basis of floral variation in the Brassicaceae Master of Philosophy Master Full Time Mrs Jayashrini Sakunthala Madawala
2017 Principal Supervisor Investigating the Role of the PIRNA Pathway in Cancer Progression Doctor of Philosophy Doctorate Full Time Miss Eunice Hsiu Yee Lee
2016 Co-Supervisor The Role of 5-Methly Cytosine during Plant Development Doctor of Philosophy Doctorate Full Time Miss Jing Zhao
2016 Principal Supervisor Investigating the molecular basis of Monotreme biology for application in conservation. Doctor of Philosophy Doctorate Full Time Miss Tahlia Jade Perry
2012 Principal Supervisor Investigating the Function of the piRNA Pathway in Ovary and Ovarian Cancer Doctor of Philosophy Doctorate Full Time Mr Reuben Jacob

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2017 Principal Supervisor Investigating the Dynamics of Interchromosonal Interactions and CTCF Site Methylation at the IGF2 Locus in Mammalian Evolution and Human Disease Master of Philosophy Master Full Time Nicole Marie Williams
2010 - 2015 Principal Supervisor Evolution of Mammalian Sex Chromosomes and Sex Determination Genes: Insights from Monotremes Doctor of Philosophy Doctorate Full Time Ms Deborah Fernanda Toledo-Flores
2010 - 2012 Principal Supervisor A First Look at Monotreme Meiotic Recombination Master of Science Master Full Time Miss Sonia Adeline Horan
2010 - 2015 Principal Supervisor Investigating Function and Evolution of Genes and Proteins Involved in Metabolic Control in Mammals Doctor of Philosophy Doctorate Full Time Ms Chuan He
2009 - 2015 Principal Supervisor Investigating the evolution of replication timing and monoallelic expression in mammals and birds Doctor of Philosophy Doctorate Full Time Miss Megan Wright
2009 - 2012 Principal Supervisor Function and Evolution of the piRNA Pathway in the Amniote Gonad and Human Ovarian Cancer Doctor of Philosophy Doctorate Full Time Miss Shu Ly Lim
2009 - 2015 Principal Supervisor Investigating the Organisation of the Platypus Sex Chromosome Chain During Meiotic Prophase I Doctor of Philosophy Doctorate Full Time Mr Aaron Casey
2008 - 2009 Co-Supervisor Identification and Analysis of the Two Tau Paralogues in Zebrafish Master of Science Master Full Time Miss Mengqi Chen

Memberships

Date Role Membership Country
2015 - ongoing Member ARC College of Experts Australia

Editorial Boards

Date Role Editorial Board Name Institution Country
2013 - ongoing Associate Editor BMC Genomics

Offices Held

Date Office Name Institution Country
2006 - 2016 ARC research fellow and group leader The University of Adelaide Australia
2006 - 2006 Lecturer in Genetics The University of Adelaide Australia
2003 - 2005 ARC research fellow Australian National University Australia
2001 - 2002 Postdoctoral researcher Australian National University
2001 - 2001 Postdoctoral researcher Max Planck Insitute of Molecular Genetics Germany
Position
Genetics Lecturer
Phone
83134812
Fax
8313 4362
Campus
North Terrace
Building
Molecular Life Sciences, floor 2
Room Number
2 11
Org Unit
Genetics & Evolution

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