Dr Frances Corrigan
Associate Prof/Reader
School of Pharmacy and Biomedical Science
College of Health
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
A/Prof Corrigan is a research active member of the Discipline of Anatomy and Pathology, School of Biomedicine at the University of Adelaide. After completion of her PhD in Dec 2011 investigating neuroprotective agents for traumatic brain injury she undertook local (UofA) postdoctoral training gaining research expertise in models of psychiatric disorders. She currently leads the Head Injury Group within the School of Biomedicine investigating both the short and long-term effects of traumatic brain injury, the role of exogenous factors such as sex and age and how to intervene to prevent long-term consequences.
Research
I lead the Head Injury Group, which liaises closely with the Translational Neuropathology lab and CANDL . My research is primarily focused on the mechanisms whereby concussion or mild traumatic brain injury can lead to the development of neurodegeneration, with particular interest in the role of neuroinflammation. This research also aims to identify novel pharmacological agents to prevent the long-term consequences of concussion.
Current projects:
1) Mapping the spread of toxic tau following traumatic brain injury to develop new biomarkers to identify those at risk of later developing dementia.
2) Understanding the temporal profile of axonal injury following traumatic brain injury in order to develop new treatments
3) Investigating whether the neuroinflammatory response influenced by age at which a traumatic brain injury occurs? Can we target this process to optimise treatment strategy dependent on age at injury.
4) Developing novel pre-clinical models of traumatic brain injury that more closely replicate the clinical situation
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2020 | Award | CNBP Collaboration Prize | University of Adelaide | Australia | 3000 |
| 2017 | Award | South Australia Tall Poppy | - | Australia | - |
| 2012 | Achievement | Fresh Science South Australian State Finalist | - | Australia | - |
| 2012 | Award | Student Travel Award, International Neurotrauma Society | - | - | - |
| 2011 | Award | Faculty of Health Sciences Travel Award, University of Adelaide | - | Australia | - |
| 2011 | Award | Student Travel Award, Australian Neuroscience Society Meeting | - | Australia | - |
| 2010 | Award | School of Medical Sciences Travel Award, University of Adelaide | - | Australia | - |
| 2010 | Award | Poster Prize- Faculty of Health Sciences Research Expo | University of Adelaide | Australia | - |
| 2010 | Award | Student Travel Award, Australian Neuroscience Society Meeting | - | Australia | - |
| 2008 | Scholarship | Australian Postgraduate Research Award | University of Adelaide | - | - |
| Year | Citation |
|---|---|
| 2024 | George, R., Krieg, J., & Corrigan, F. (2024). Substance P in neurotrauma. In R. Vink (Ed.), Substance P: from Pain to Cancer (pp. 423-438). Elsevier. DOI |
| 2018 | Holmes, J., Corrigan, F., & Hutchinson, M. R. (2018). Neuroimmunopharmacology at the Interface of Inflammation and Pharmacology Relevant to Depression. In B. T. Baune (Ed.), Inflammation and Immunity in Depression Basic Science and Clinical Applications (pp. 223-240). United Kingdom: Academic Press. DOI |
| 2012 | Turner, R., Corrigan, F., & Vink, R. (2012). Magnesium in acute brain injury. In Y. Li, & J. Zhang (Eds.), Metal Ion in Stroke (1 ed., pp. 445-460). United States: Springer. DOI Scopus1 |
| 2011 | Cook, N., Corrigan, F., & Van Den Heuvel, C. (2011). The role of magnesium in CNS injury. In R. Vink, & M. Nechifor (Eds.), Magnesium in the Central Nervous System (pp. 167-179). Australia: University of Adelaide Press. DOI Scopus8 |
| Year | Citation |
|---|---|
| 2023 | Krieg, J., Leonard, A., Turner, R., & Corrigan, F. (2023). EVALUATION OF DIFFUSE AXONAL INJURY IN PAEDIATRIC AND ADULT NOVEL GYRENCEPHALIC FERRET MODELS OF TBI. In JOURNAL OF NEUROTRAUMA Vol. 40 (pp. A55). TX, Austin: MARY ANN LIEBERT, INC. |
| 2015 | Plummer, S., Thornton, E., Corrigan, F., Vink, R., Cappai, R., & Heuvel, C. V. D. (2015). Investigation of the amyloid precursor protein derivative APP96-110 as a novel therapeutic agent following traumatic brain injury. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 145). Cairns, AUSTRALIA: WILEY-BLACKWELL. |
| 2015 | McAteer, K., Corrigan, F., Thornton, E., Turner, R., & Vink, R. (2015). Short and long term behavioral and pathological changes in a novel rodent model of repetitive mild traumatic brain injury. In Abstracts of the 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, as published in Vol. 134 (pp. 340-341). Cairns, AUSTRALIA: Wiley-Blackwell. DOI |
| 2015 | Corrigan, F., McAteer, K., & Vink, R. (2015). Toll-like receptor 4 activation exacerbates injury following repetitive mild traumatic brain injury. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 196-197). Cairns, AUSTRALIA: WILEY-BLACKWELL. |
| 2011 | Corrigan, F., Pham, C., Vink, R., Masters, C., Blumbergs, P., Cappai, R., & Van den Heuvel, C. (2011). SAPPALPHA RESCUES DEFICITS IN AMYLOID PRECURSOR PROTEIN KNOCKOUT MICE FOLLOWING TRAUMATIC BRAIN INJURY. In JOURNAL OF NEUROTRAUMA Vol. 28 (pp. A67). Shanghai, PEOPLES R CHINA: MARY ANN LIEBERT INC. |
| 2011 | Corrigan, F., Vink, R., Masters, C., Blumbergs, P., Cappai, R., & Van den Heuvel, C. (2011). CHARACTERISING THE EFFECTS OF AMYLOID PRECURSOR PROTEIN KNOCKOUT ON OUTCOME FOLLOWING TRAUMATIC BRAIN INJURY. In JOURNAL OF NEUROTRAUMA Vol. 28 (pp. A28). Shanghai, PEOPLES R CHINA: MARY ANN LIEBERT INC. |
| 2011 | Cappai, R., Corrigan, F., Pham, C. L., Vink, R., Masters, C. L., Blumbergs, P. C., & van den Heuvel, C. (2011). DEFINING THE NEUROPROTECTIVE ACTIVITY OF ENDOGENOUSLY EXPRESSED AMYLOID PRECURSOR PROTEIN IN TRAUMATIC BRAIN INJURY. In JOURNAL OF NEUROCHEMISTRY Vol. 118 (pp. 209). WILEY. |
| 2009 | Corrigan, F., Cappai, R., Vink, R., & Van Den Heuvel, C. (2009). DETERMINING THE NEUROPROTECTIVE PROPERTIES OF THE AMYLOID PRECURSOR PROTEIN <i>IN VIVO</i>. In JOURNAL OF NEUROTRAUMA Vol. 26 (pp. A95). Santa Barbara, CA: MARY ANN LIEBERT INC. |
| Year | Citation |
|---|---|
| 2019 | Sharkey, J., Turner, R., Leonard, A., & Corrigan, F. (2019). INVESTIGATING THE PATTERN OF AXONAL INJURY FOLLOWING TRAUMATIC BRAIN INJURY OF VARYING INTENSITY IN A LARGE ANIMAL MODEL. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Pittsburgh, PA: MARY ANN LIEBERT, INC. |
| 2019 | Corrigan, F., Kaukas, L., Collins-Praino, L., & Holmes, J. (2019). EFFECT OF A MILD TRAUMATIC BRAIN INJURY DURING ADOLESCENCE ON EXECUTIVE FUNCTION IN ADULTHOOD. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Pittsburgh, PA: MARY ANN LIEBERT, INC. |
| 2018 | Cappai, R., Inampudi, C., Corrigan, F., Lam, L., Roberts, B., Thornton, E., . . . Van den Heuvel, C. (2018). DELINEATING THE NEUROPROTECTIVE ROLE OF THE AMYLOID PRECURSOR PROTEIN FAMILY IN TRAUMATIC BRAIN INJURY. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Toronto, CANADA: MARY ANN LIEBERT, INC. |
| 2017 | Plummer, S. L., Thornton, E., Corrigan, F., Vink, R., Cappai, R., & Van den Heuvel, C. (2017). Evaluating the amyloid precursor protein derivative, APP96-110, as a novel therapeutic agent following traumatic brain injury. Poster session presented at the meeting of JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY: SAGE PUBLICATIONS INC. |
| 2016 | Corrigan, F., & Vink, R. (2016). Toll like receptor 4 activation can be either detrimental or beneficial following mild repetitive traumatic brain injury depending on timing of activation. Poster session presented at the meeting of Abstracts of the 12th Symposium of the International Neurotrauma Society, as published in Journal of Neurotrauma. Cape Town, SOUTH AFRICA: Mary Ann Liebert. DOI |
| 2016 | Collins-Praino, L., Teng, J., Colton, H., Van den Heuvel, C., & Corrigan, F. (2016). INVESTIGATING THE COMPLEX RELATIONSHIP BETWEEN NEUROINFLAMMATION, NEURODEGENERATION AND LONG-TERM FUNCTIONAL OUTCOMES IN AN EXPERIMENTAL MODEL OF TRAUMATIC BRAIN INJURY. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Cape Town, SOUTH AFRICA: MARY ANN LIEBERT, INC. |
| 2015 | Morgan, J. A., Corrigan, F., Jaehne, E., Jawahar, C., Singhal, G., & Baune, B. T. (2015). "Does exercise cessation induce depression in middle age?" (oral presentation). Poster session presented at the meeting of Florey International Postgraduate Research Conference. |
| 2014 | Morgan, J. A., Corrigan, F., Jaehne, E., & Baune, B. T. (2014). "Chronic physical exercise induced adaptations in the brain-stem and hypothalamus: A brief review of exercise effects on stress responses, the circadian clock, and energy balance metabolism.. Poster session presented at the meeting of The Society for Mental Health Research. |
| 2014 | Morgan, J. A., Corrigan, F., Jaehne, E., & Baune, B. T. (2014). "Exercise induced effects on anxiety, cognition, and depression in early adulthood and middle age". Poster session presented at the meeting of The Society for Mental Health Research. |
| 2014 | Morgan, J. A., Corrigan, F., Jaehne, E., & Baune, B. T. (2014). "Physical exercise impacts on cognitive and depression-like behaviours in C57BL/6 mice". Poster session presented at the meeting of Australasian Neurosciences Society 34th Annual Meeting. |
| 2014 | McAteer, K., Corrigan, F., Thornton, E., van den Heuvel, C., & Vink, R. (2014). CHARACTERISATION OF A NOVEL MODEL OF CHRONIC TRAUMATIC ENCEPHALOPATHY. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Budapest, HUNGARY: MARY ANN LIEBERT, INC. |
| 2014 | Plummer, S., Thornton, E., Corrigan, F., Vink, R., Cappai, R., & van den Heuvel, C. (2014). EVALUATING APP96-110, A PEPTIDE DERIVED FROM THE AMYLOID PRECURSOR PROTEIN, AS A NOVEL THERAPEUTIC AGENT AGAINST TRAUMATIC BRAIN INJURY. Poster session presented at the meeting of JOURNAL OF NEUROTRAUMA. Budapest, HUNGARY: MARY ANN LIEBERT, INC. |
| 2013 | Morgan, J. A., Corrigan, F., Jaehne, E., & Baune, B. T. (2013). "Exercise neurobiology: A review of the effects of exercise on regions of the brain". Poster session presented at the meeting of The University of Adelaide Faculty of Health Sciences Postgraduate Research Conference. |
| 2012 | Cappai, R., Corrigan, F., Blumbergs, P., Vink, R., & van den Heuvel, C. (2012). Delineating The Neuroprotective Region Of The Amyloid Precursor Protein (APP) Following Traumatic Brain Injury. Poster session presented at the meeting of BRAIN INJURY. INFORMA HEALTHCARE. |
Corrigan F, Turner R, Abou-Hamden A. Targeting inflammation to prevent brain swelling following paediatric head injury
2019-2020: 214,500, James and Diana Ramsey Foundation
Corrigan F, Nasrallah F, Collins-Praino LE, Developing imaging biomarkers that predict pre-frontal cortex deficits following
concussive insults in adolescence. 2019: 35,246, Neurosurgical Research Foundation
Corrigan F, Vink R, Turner RJ, Van Den Heuvel C, Cappai R, Preclinical evaluation of the novel therapeutic compound
APP96-110 in an ovine model of traumatic brain injury. 2018-2020: 874,744.50. NHMRC
Corrigan F, Collins-Praino LE, The role of alcohol in promoting the development of neurodegeneration following repetitive
mild traumatic brain injury 2018: 24 440, Neurosurgical Research Foundation
Leonard AV, Corrigan F, Collins-Praino LE, Spinal Cord Injury Research Program – Equipment funding. 2016: 30,000,
Neurosurgical Research Foundation
Corrigan F. The role of the SP-NK1 system in promoting the vulnerability to concussion in adolescence. 2017: $19,000
Neurosurgical Research Foundation
Corrigan, F. Investigating the effects of toll-like receptor 4 activation on outcome following repeated concussion 2016: 22,000
Neurosurgical Research Foundation
Corrigan, F: Role of alcohol induced changes in the gut microbiome promotes the development of depression via induction of
a systemic inflammatory response. 2015: $19,000. School of Medical Sciences, Kick-Start Funding, University of Adelaide
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 | Principal Supervisor | Does a concomitant TBI influence the inflammatory response following a spinal cord injury? | Doctor of Philosophy | Doctorate | Full Time | Mr Yi Feng Liu |
| 2025 | Principal Supervisor | Is oligodendrocyte dysfunction the key to axonal degeneration following head injury? | Doctor of Philosophy | Doctorate | Full Time | Miss Hasini Kapuwelle |
| 2025 | Principal Supervisor | Defining actions of complement to identify pan-therapeutic targets in traumatic brain injury | Doctor of Philosophy | Doctorate | Full Time | Miss Eloise Joy Arthur |
| 2023 | Principal Supervisor | Utility of Rotational Thromboelastometry in Neurosurgical Management of Acute Severe Traumatic Brain Injury | Doctor of Philosophy | Doctorate | Part Time | Mr Abhiram Devendra Hiwase |
| 2023 | Principal Supervisor | Evaluation of novel therapeutics in a novel gyrencephalic model of traumatic brain injury | Doctor of Philosophy | Doctorate | Full Time | Mr Carl Llewelyn Hooper |
| 2021 | Co-Supervisor | Evaluating the role of concomitant traumatic brain injury on the development of neuropathic pain following traumatic spinal cord injury | Doctor of Philosophy | Doctorate | Part Time | Miss Keziah Jane Skein |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2022 - 2025 | Co-Supervisor | Understanding the Role of Environmental Exposures in Parkinson’s Disease: Synergistic Effects of Traumatic Brain Injury in Combination with Additional Risk Factors on the Nigrostriatal and Olfactory Systems | Doctor of Philosophy | Doctorate | Full Time | Ms Samantha Elizabeth Edwards |
| 2021 - 2024 | Principal Supervisor | Characterisation of a novel pre-clinical model of diffuse axonal injury | Doctor of Philosophy | Doctorate | Full Time | Mr Justin Leigh Krieg |
| 2019 - 2024 | Co-Supervisor | Exploring the Behavioural and Brain Basis of the Link Between Traumatic Brain Injury and Parkinson’s disease | Doctor of Philosophy | Doctorate | Full Time | Miss Ing Chee Wee |
| 2019 - 2021 | Co-Supervisor | Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non-Pharmacological Approaches | Doctor of Philosophy | Doctorate | Full Time | Miss Bianca Laura Guglietti |
| 2017 - 2021 | Co-Supervisor | Bridging the Gap in Clinical Translation: Optimising an Ovine Model of Traumatic Brain Injury | Doctor of Philosophy | Doctorate | Full Time | Miss Jessica May Sharkey |
| 2016 - 2019 | Co-Supervisor | From Trauma to Neurodegeneration: A One-Year Time Progression of Functional Impairments and its Associated Neuropathological Link Following Varied Severity of Experimental Diffuse Traumatic Brain Injury | Doctor of Philosophy | Doctorate | Full Time | Miss Alina Arulsamy |
| 2014 - 2018 | Co-Supervisor | Investigating Amyloid Precursor Protein Derivatives As Novel Therapeutic Agents Following Traumatic Brain Injury | Doctor of Philosophy | Doctorate | Full Time | Dr Stephanie Lauren Plummer |
| 2014 - 2018 | Co-Supervisor | The Role of Substance P in Chronic Traumatic Encephalopathy | Doctor of Philosophy | Doctorate | Full Time | Kelly Marie McAteer |
| 2014 - 2022 | Co-Supervisor | Experimental Models of Alcohol Induced Inflammation-associated Depressive-like Behaviour | Doctor of Philosophy | Doctorate | Part Time | Joshua Luke Holmes |
| 2013 - 2019 | Co-Supervisor | The Effects of Long-Term Exercise and Stopping Long-Term Exercise on Behaviours and Neurobiology | Doctor of Philosophy | Doctorate | Full Time | Ms Julie A Morgan |
| 2013 - 2020 | Co-Supervisor | The Differential Effects of Short-Term Physical Exercise, Environmental Enrichment and their Combination, and Short-and-Long-Term Environmental Enrichment on Behavior and Associated Molecular Changes in the Brain of C57BL/6 Mice | Doctor of Philosophy | Doctorate | Part Time | Dr Gaurav Singhal |
| Date | Role | Membership | Country |
|---|---|---|---|
| 2016 - ongoing | Member | Adelaide Centre for Neuroscience | Australia |
| 2016 - ongoing | Member | Australian Society of Medical Research | Australia |
| 2016 - ongoing | Member | Australian Neuroscience Society | Australia |
| 2016 - ongoing | Member | International Neurotrauma Society | Australia |