Frances Corrigan

Dr Frances Corrigan

Associate Prof/Reader

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


A/Prof Corrigan is a research active member of the Discipline of Anatomy and Pathology, School of Biomedicine at the University of Adelaide. After completion of her PhD in Dec 2011 investigating neuroprotective agents for traumatic brain injury she undertook local (UofA) postdoctoral training gaining research expertise in models of psychiatric disorders. She currently leads the Head Injury Group within the School of Biomedicine investigating both the short and long-term effects of traumatic brain injury, the role of exogenous factors such as sex and age and how to intervene to prevent long-term consequences.

Research

I lead the Head Injury Group, which liaises closely with the Translational Neuropathology lab and CANDL . My research is primarily focused on the mechanisms whereby concussion or mild traumatic brain injury can lead to the development of neurodegeneration, with particular interest in the role of neuroinflammation.  This research also aims to identify novel pharmacological agents to prevent the long-term consequences of concussion. 

Current projects:

1) Mapping the spread of toxic tau following traumatic brain injury to develop new biomarkers to identify those at risk of later developing dementia.

2) Understanding the temporal profile of axonal injury following traumatic brain injury in order to develop new treatments

3) Investigating whether the neuroinflammatory response influenced by age at which a traumatic brain injury occurs? Can we target this process to optimise treatment strategy dependent on age at injury. 

4) Developing novel pre-clinical models of traumatic brain injury that more closely replicate the clinical situation

 

  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2020 Award CNBP Collaboration Prize University of Adelaide Australia 3000
    2017 Award South Australia Tall Poppy - Australia -
    2012 Achievement Fresh Science South Australian State Finalist - Australia -
    2012 Award Student Travel Award, International Neurotrauma Society - - -
    2011 Award Faculty of Health Sciences Travel Award, University of Adelaide - Australia -
    2011 Award Student Travel Award, Australian Neuroscience Society Meeting - Australia -
    2010 Award School of Medical Sciences Travel Award, University of Adelaide - Australia -
    2010 Award Poster Prize- Faculty of Health Sciences Research Expo University of Adelaide Australia -
    2010 Award Student Travel Award, Australian Neuroscience Society Meeting - Australia -
    2008 Scholarship Australian Postgraduate Research Award University of Adelaide - -

Corrigan F, Turner R, Abou-Hamden A. Targeting inflammation to prevent brain swelling following paediatric head injury

2019-2020: 214,500, James and Diana Ramsey Foundation

 

Corrigan F, Nasrallah F, Collins-Praino LE, Developing imaging biomarkers that predict pre-frontal cortex deficits following

concussive insults in adolescence. 2019: 35,246, Neurosurgical Research Foundation

 

Corrigan F, Vink R, Turner RJ, Van Den Heuvel C, Cappai R, Preclinical evaluation of the novel therapeutic compound

APP96-110 in an ovine model of traumatic brain injury. 2018-2020: 874,744.50. NHMRC

 

Corrigan F, Collins-Praino LE, The role of alcohol in promoting the development of neurodegeneration following repetitive

mild traumatic brain injury 2018: 24 440, Neurosurgical Research Foundation

                                       

Leonard AV, Corrigan F, Collins-Praino LE, Spinal Cord Injury Research Program – Equipment funding. 2016: 30,000,

Neurosurgical Research Foundation

 

Corrigan F. The role of the SP-NK1 system in promoting the vulnerability to concussion in adolescence. 2017: $19,000

Neurosurgical Research Foundation

 

Corrigan, F. Investigating the effects of toll-like receptor 4 activation on outcome following repeated concussion 2016: 22,000

Neurosurgical Research Foundation

                                          

Corrigan, F: Role of alcohol induced changes in the gut microbiome promotes the development of depression via induction of

a systemic inflammatory response. 2015: $19,000. School of Medical Sciences, Kick-Start Funding, University of Adelaide

 

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2023 Principal Supervisor Using a novel gyrencephalic model of pediatric injury to evaluate new therapeutics. Doctor of Philosophy Doctorate Full Time Mr Giuseppe Rinaldi
    2023 Principal Supervisor Utility of Rotational Thromboelastometry in Neurosurgical Management of Acute Severe Traumatic Brain Injury Doctor of Philosophy Doctorate Part Time Mr Abhiram Hiwase
    2023 Principal Supervisor Evaluation of novel therapeutics in a novel gyrencephalic model of traumatic brain injury Doctor of Philosophy Doctorate Full Time Mr Carl Llewelyn Hooper
    2022 Co-Supervisor Assessing olfactory system pathology and accelerated a-synuclein spread following
    Traumatic Brain Injury, and their role in the development of Parkinson's Disease pathology.
    Doctor of Philosophy Doctorate Full Time Ms Samantha Elizabeth Edwards
    2022 Principal Supervisor Characterising the role of cognitive dysfunction and spread of underlying tau pathology in the development of Alzheimer's disease following traumatic brain injury Doctor of Philosophy Doctorate Part Time Miss Eleanor Rose Bowley-Schubert
    2021 Principal Supervisor Characterisation of a novel pre-clinical model of diffuse axonal injury Doctor of Philosophy Doctorate Full Time Mr Justin Leigh Krieg
    2021 Co-Supervisor Evaluating the role of concomitant traumatic brain injury on the development of neuropathic pain following traumatic spinal cord injury Doctor of Philosophy Doctorate Full Time Miss Keziah Jane Skein
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2024 Co-Supervisor Exploring the Behavioural and Brain Basis of the Link Between Traumatic Brain Injury and Parkinson’s disease Doctor of Philosophy Doctorate Full Time Miss Ing Chee Wee
    2019 - 2021 Co-Supervisor Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non-Pharmacological Approaches Doctor of Philosophy Doctorate Full Time Miss Bianca Laura Guglietti
    2017 - 2021 Co-Supervisor Bridging the Gap in Clinical Translation: Optimising an Ovine Model of Traumatic Brain Injury Doctor of Philosophy Doctorate Full Time Miss Jessica May Sharkey
    2016 - 2019 Co-Supervisor From Trauma to Neurodegeneration: A One-Year Time Progression of Functional Impairments and its Associated Neuropathological Link Following Varied Severity of Experimental Diffuse Traumatic Brain Injury Doctor of Philosophy Doctorate Full Time Miss Alina Arulsamy
    2014 - 2018 Co-Supervisor Investigating Amyloid Precursor Protein Derivatives As Novel Therapeutic Agents Following Traumatic Brain Injury Doctor of Philosophy Doctorate Full Time Dr Stephanie Lauren Plummer
    2014 - 2018 Co-Supervisor The Role of Substance P in Chronic Traumatic Encephalopathy Doctor of Philosophy Doctorate Full Time Kelly Marie McAteer
    2014 - 2022 Co-Supervisor Experimental Models of Alcohol Induced Inflammation-associated Depressive-like Behaviour Doctor of Philosophy Doctorate Part Time Joshua Luke Holmes
    2013 - 2019 Co-Supervisor The Effects of Long-Term Exercise and Stopping Long-Term Exercise on Behaviours and Neurobiology Doctor of Philosophy Doctorate Full Time Ms Julie A Morgan
    2013 - 2020 Co-Supervisor The Differential Effects of Short-Term Physical Exercise, Environmental Enrichment and their Combination, and Short-and-Long-Term Environmental Enrichment on Behavior and Associated Molecular Changes in the Brain of C57BL/6 Mice Doctor of Philosophy Doctorate Part Time Dr Gaurav Singhal
  • Memberships

    Date Role Membership Country
    2016 - ongoing Member Adelaide Centre for Neuroscience Australia
    2016 - ongoing Member Australian Society of Medical Research Australia
    2016 - ongoing Member Australian Neuroscience Society Australia
    2016 - ongoing Member International Neurotrauma Society Australia
  • Position: Associate Prof/Reader
  • Phone: 83134150
  • Email: frances.corrigan@adelaide.edu.au
  • Fax: 83133356
  • Campus: North Terrace
  • Building: Helen Mayo South, floor 5
  • Org Unit: Medical Sciences

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