School of Biological Sciences
Faculty of Sciences
My background is a engineering degree in "Brewery sciences and beverage technology" from the Technical University of Munich. This was furthered by a PhD in Proteomics at the lab of Prof. Dr. Dr. Angelika Görg.
My main focus is the identification of novel diagnostic markers of early stage ovarian cancer. Ovarian cancer is the eighth most common cancer in women in Australia and the leading cause of gynecological cancer related deaths. Patients are usually diagnosed with advanced disease stages where the 5-year overall survival rate is low. This stands in contrast to patients diagnosed with stage I disease where the 5-year overall survival rate is 93%. This means markers for diagnosis of early disease stages would have a major impact on the outcome of ovarian cancer, vastly improving survival rates.
A further focus of my work is on the molecular characterization of the ovarian cancer biomarker CA125. Although CA125 is a widely used marker for ovarian cancer it is lacking specificity and sensitivity. Further, serum levels of CA125 are only increased in around 50% of early stage ovarian cancer. Improvement of the diagnostic capability of CA125 would therefore be valuable.
Additional projects I'm involved in are the application of MALDI mass spectrometry profiling for the identification of spoilage microorganisms for biological quality control in the South Australian beverage industry and a cross-disciplinary project between Proteomics and Geo-microbiology for the development of an ultra-sensitive biodetector for gold.
Language Competency English Can read, write, speak, understand spoken and peer review German Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2005 - 2010 Technische Universitaet Muenchen, Ernst-Moritz-Arndt Universitaet Greifswald Germany Dr. rer. nat. 2000 - 2005 Technische Universitaet Muenchen Germany Diplom-Ingenieur
Date Citation 2016 Schubert,KO, Weiland,F, Baune,BT, Hoffmann,P, 2016, The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: a review, Proteomics, 16, 11-12, 1747-1758 10.1002/pmic.201500460 2016 Zammit,CM, Weiland,F, Brugger,J, Wade,B, Winderbaum,LJ, Nies,DH, Southam,G, Hoffmann,P, Reith,F, 2016, Proteomic responses to gold(III)-toxicity in the bacterium Cupriavidus metallidurans CH34, Metallomics, 8, 11, 1204-1216 10.1039/c6mt00142d 2016 Turvey,ME, Weiland,F, Meneses,J, Sterenberg,N, Hoffmann,P, 2016, Identification of beer spoilage microorganisms using the MALDI Biotyper platform, Applied Microbiology and Biotechnology, 100, 6, 2761-2773 10.1007/s00253-016-7344-8 2016 Weiland,F, Arentz,G, Klingler-Hoffmann,M, McCarthy,P, Lokman,NA, Kaur,G, Oehler,MK, Hoffmann,P, 2016, A novel IEF peptide fractionation method reveals a detailed profile of N-terminal Acetylation in chemotherapy-responsive and -resistant ovarian cancer cells, Journal of Proteome Research, 15, 11, 4073-4081 10.1021/acs.jproteome.6b00053 2015 Arentz,G, Weiland,F, Oehler,MK, Hoffmann,P, 2015, State of the art of 2D DIGE, Proteomics - Clinical Applications, 9, 3-4, 277-288 10.1002/prca.201400119 2014 Weiland,F, Zammit,C, Reith,F, Hoffmann,P, 2014, High resolution two-dimensional electrophoresis of native proteins, Electrophoresis, 35, 12-13, 1893-1902 10.1002/elps.201400060 2014 Humphries,J, Penno,M, Weiland,F, Klingler-Hoffmann,M, Zuber,A, Boussioutas,A, Ernst,M, Hoffmann,P, 2014, Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer, Biochimica et Biophysica Acta - Proteins and Proteomics, 1844, 5, 1051-1058 10.1016/j.bbapap.2014.01.018 2012 Weiland,F, Martin,K, Oehler,M, Hoffmann,P, 2012, Deciphering the molecular nature of ovarian cancer biomarker CA125, International Journal of Molecular Sciences, 13, 8, 10568-10582 10.3390/ijms130810568 2012 Weiland,F, Fritz,K, Oehler,M, Hoffmann,P, 2012, Methods for identification of CA125 from ovarian cancer ascites by high resolution mass spectrometry, International Journal of Molecular Sciences, 13, 8, 9942-9958 10.3390/ijms13089942 2009 Weiss,W, Weiland,F, Luck,C, 2009, Protein detection and quantitation technologies for gel-based proteome analysis, Methods in Molecular Biology, 564, 4, 59-82 10.1007/978-1-60761-157-8_4 2009 Gorg,A, Drews,O, Luck,C, Weiland,F, Weiss,W, 2009, 2-DE with IPGs, Electrophoresis, 30, Suppl 1, S122-S132 10.1002/elps.200900051 2008 Serra,D, Lucking,G, Weiland,F, Schulz,S, Gorg,A, Yantorno,O, Ehling-Schulz,M, 2008, Proteome approaches combined with Fourier transform infrared spectroscopy revealed a distinctive biofilm physiology in Bordetella pertussis, Proteomics, 8, 23-24, 4995-5010 10.1002/pmic.200800218 2007 Fanous,A, Weiland,F, Luck,C, Gorg,A, Friess,A, Parlar,H, 2007, A proteome analysis of Corynebacterium glutamicum after exposure to the herbicide 2,4-dichlorophenoxy acetic acid (2,4-D), Chemosphere, 69, 1, 25-31 10.1016/j.chemosphere.2007.04.075
Date Citation 2007 Gorg,A, Klaus,A, Lueck,C, Weiland,F, Weiss,W, 2007, Two-dimensional electrophoresis with immobilized pH gradients for proteome analysis
Date Citation 2013 Ahern,J, Mukaro,V, Hodge,G, Dean,M, Weiland,F, Pizzutto,S, Reynolds,PN, Hodge,S, 2013, Oxidative stress decreases functional airway mannose binding lectin in COPD, 2013 Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meetings, Darwin, N.T. 10.1111/resp.12046 2006 Gorg,A, Klaus,A, Lueck,C, Weiland,F, Weiss,W, 2006, Two-dimensional electrophoresis for proteome analysis; Outdated or still indispensable? 2005 Weiland,F, Lueck,C, Klaus,A, Reil,G, Goerg,A, 2005, Proteome analysis of C-glutamicum wild-type strains and mutants overproducing L-lysine
Date Citation 2010 Weiland,F; 2010; Differentielle Proteomanalyse von Ewingsarkom- und Neuroblastomzelllinien sowie methodische Arbeiten zur Analyse des Gesamtproteoms von Modell-Mikroorganismen
Institute for Photonics and Advanced Sensing (IPAS), University of Adelaide, Pilot Project Grant: "Identification of spoilage micro-organisms in beer using mass spectrometry profiling"
Photonics Catalyst Program, University of Adelaide, Coopers Brewery Ltd. (Adelaide), South Australian Government: „Rapid identification of beer-spoilage micro-organisms using mass-spectrometry profiling“
Environment Institute, University of Adelaide: „An Ultra-sensitive Biosensor for the Detection of Gold“
Photonics Catalyst Program, University of Adelaide, Hills Cider Company (Adelaide), South Australian Government: „Improving microbial quality control practices within the SA beverage industry“
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