Adelaide Medical School
Faculty of Health and Medical Sciences
I am a PhD student in the in the Neurovascular Research Group with the supervision of Dr Quenten Schwarz and Hayley Ramshaw. My research interests include the understanding of signalling pathways controlling neural stem cell development with the aim of identifying molecular defects underlying neurodevelopmental and neuropsychiatric disorders, particularly schizophrenia.
Withdrawal from reality, illogical patterns of thinking, delusions, hallucination
….these are some of symptoms that schizophrenia patients experience.
A neuropsychiatric disorder affecting about 1 % of the world’s population. Schizophrenia is clinically defined, meaning that it is diagnosed based on its clinical symptoms, while the actual cause of the disorder remains unknown. Current treatments with antipsychotic are partially effective, only treating the positive symptoms (i.e. hallucinations) but do not improve the cognitive or social behaviour defects.
Using schizophrenia patient samples, researchers have identified a number of genes which may be contributing to the disorder, one of which includes 14-3-3ζ. Our research group found that removing the 14-3-3ζ gene from mice results in behavioural and anatomical defects similar to schizophrenia patients and other related disorders.
Neural stem cells are the hallmarks of neurodevelopment, as they give birth to cells that differentiate into neurons making up the central nervous system.These immature neurons migrate from their birth place to their allocated position within the brain, followed by their maturation into functional neurons that form synapses.
We have found that removal of the 14-3-3ζ gene in mice affects the neurons in several stages of their development, these including neural stem cell dynamics, neuronal migration and synapse formation.
Awards and Achievements
Date Type Title Institution Name Amount 2013 Student Travel Award Australian Neuroscience Society 2013 School of Medicine Poster Prize Faculty of Health Science Postgraduate Conference, Adelaide University 2013 Australian Protein Group Student Awards Australian Protein Group 2012 Cell Biology Student Poster Prize Australian and New Zealand Society for Cell and Development Biology
Language Competency Arabic Can speak and understand spoken
Date Institution name Country Title 2011 University of Adelaide Australia PhD 2009 Flinders University Australia Bachelors of Science (Honours) 2006 - 2008 Flinders University Australia Bachelors of Medical Science
Date Citation 2015 Jaehne,EJ, Ramshaw,H, Xu,X, Saleh,E, Clark,SR, Schubert,KO, Lopez,A, Schwarz,Q, Baune,BT, 2015, In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders, Pharmacology Biochemistry and Behavior, 138, 1-8 10.1016/j.pbb.2015.09.006 2015 Xu,X, Jaehne,EJ, Greenberg,Z, McCarthy,P, Saleh,E, Parish,CL, Camera,D, Heng,J, Haas,M, Baune,BT et al, 2015, 14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders, Scientific Reports, 5, 12434-1-12434-15 10.1038/srep12434 2013 Ramshaw,H, Xu,X, Jaehne,E, McCarthy,P, Greenberg,Z, Saleh,E, McClure,B, Woodcock,J, Kabbara,S, Wiszniak,S et al, 2013, Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction, Translational Psychiatry, 3, e327, 1-10 10.1038/tp.2013.99
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