Eiman Saleh

Ms Eiman Saleh

PhD Student

Adelaide Medical School

Faculty of Health and Medical Sciences


I am a PhD student in the in the Neurovascular Research Group with the supervision of Dr Quenten Schwarz and Hayley Ramshaw. My research interests include the understanding of signalling pathways controlling neural stem cell development with the aim of identifying molecular defects underlying neurodevelopmental and neuropsychiatric disorders, particularly schizophrenia.

Neuron Image
Withdrawal from reality, illogical patterns of thinking, delusions, hallucination
                        ….these are some of symptoms that schizophrenia patients experience.  
Schizophrenia

A neuropsychiatric disorder affecting about 1 % of the world’s population. Schizophrenia is clinically defined, meaning that it is diagnosed based on its clinical symptoms, while the actual cause of the disorder remains unknown. Current treatments with antipsychotic are partially effective, only treating the positive symptoms (i.e. hallucinations) but do not improve the cognitive or social behaviour defects.      

   

Understanding SchizophreniaBrain Image

Using schizophrenia patient samples, researchers have identified a number of genes which may be contributing to the disorder, one of which includes 14-3-3ζ. Our research group found that removing the 14-3-3ζ gene from mice results in behavioural and anatomical defects similar to schizophrenia patients and other related disorders. 

 

Findings

Neural stem cells
Neural stem cells from embryonic mouse brain. Green: undifferentiated neural stem cells, Red: immature neurons,  Blue nucleus 
Migrating neurons
Migrating neurons labelled with a green fluorescent protein. 

 

Neural stem cells are the hallmarks of neurodevelopment, as they give birth to cells that differentiate into neurons making up the central nervous system.These immature neurons migrate from their birth place to their allocated position within the brain, followed by their maturation into functional neurons that form synapses. 

We have found that removal of the 14-3-3ζ gene in mice affects the neurons in several stages of their development, these including neural stem cell dynamics, neuronal migration and synapse formation. 

                             

                                                                                                              

 

 

 

 

 

 

 

 

 

 

    Expand
  • Awards and Achievements

    Date Type Title Institution Name Amount
    2013 Student Travel Award Australian Neuroscience Society
    2013 School of Medicine Poster Prize Faculty of Health Science Postgraduate Conference, Adelaide University
    2013 Australian Protein Group Student Awards Australian Protein Group
    2012 Cell Biology Student Poster Prize Australian and New Zealand Society for Cell and Development Biology
  • Language Competencies

    Language Competency
    Arabic Can speak and understand spoken
  • Education

    Date Institution name Country Title
    2011 University of Adelaide Australia PhD
    2009 Flinders University Australia Bachelors of Science (Honours)
    2006 - 2008 Flinders University Australia Bachelors of Medical Science
  • Research Interests

    Expand
  • Memberships

    Date Role Membership Country
    2013 - 2014 Member Australian Society for Biochemistry and Molecular Biology Australia
    2013 - 2014 Member Australian Neuroscience Society Australia
    2012 - 2014 Member Australian and New Zealand Society for Cell and Development Biology Australia

Connect With Me
External Profiles

Other Links