
Mrs Ebtihal Mustafa
Higher Degree by Research Candidate
PhD Student - DRMCRL
Adelaide Medical School
Faculty of Health and Medical Sciences
Estrogen receptor α negative (ER-) breast cancer is an aggressive subtype with limited therapeutic targets. The androgen receptor (AR) is a promising target in ER- disease, but existing preclinical data is inconsistent. Other candidate targets are transcriptional cyclin-dependent kinases 9 (CDK9) due to high rates of transcription characteristics of aggressive disease. However, targeting CDKs has been hampered by the poor selectivity of existing inhibitors. My research work aims to define the mechanisms of AR-regulated proliferation in ER- breast cancer and evaluates the efficacy of novel CDK9 inhibitors with and without AR targeted therapies, to provide preclinical evidence for a new therapeutic strategy.
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Language Competencies
Language Competency Arabic Can read, write, speak, understand spoken and peer review English Can read, write, speak and understand spoken -
Education
Date Institution name Country Title — Hashemite University, Zarqa Jordan Master of Biological Science -
Certifications
Date Title Institution name Country — Master of Biological Science Hashemite University Jordan — Bachelor of biological science Hashemite University Jordan -
Research Interests
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Journals
Year Citation 2018 Rouibah, H., Kebsa, W., Lahouel, M., Zihlif, M., Ahram, M., Aburmeleih, B., . . . El-Ameer, H. J. (2018). Erratum: Algerian propolis potentiates doxorubicin mediated anticancer effect against human pancreatic PANC-1 cancer cell line through cell cycle arrest, apoptosis induction and P-glycoprotein inhibition (Anti-Cancer Agents in Medicinal Chemistry, (2018) 18, 3, (375), 10.2174/1871520618666180110143239). Anti-Cancer Agents in Medicinal Chemistry, 18(9), 1364.
2018 Kebsa, W., Lahouel, M., Rouibah, H., Zihlif, M., Ahram, M., Abu-Irmaileh, B., . . . Al Shhab, M. (2018). Reversing multidrug resistance in chemo-resistant human lung adenocarcinoma (A549/dox) cells by algerian propolis through direct inhibiting the P-gp Efflux-pump, G0/G1 cell cycle arrest and apoptosis induction. Anti-Cancer Agents in Medicinal Chemistry, 18(9), 1330-1337.
Scopus5 Europe PMC22018 Rouibah, H., Kebsa, W., Lahouel, M., Zihlif, M., Ahram, M., Aburmeleih, B., . . . El-Amir, H. (2018). Algerian propolis potentiates doxorubicin mediated anticancer effect against human pancreatic panc-1 cancer cell line through cell cycle arrest, apoptosis induction and p-glycoprotein inhibition. Anti-Cancer Agents in Medicinal Chemistry, 18(3), 375-387.
Scopus3 Europe PMC22018 Ahram, M., Mustafa, E., Abu Hammad, S., Alhudhud, M., Bawadi, R., Tahtamouni, L., . . . Zihlif, M. (2018). The cellular and molecular effects of the androgen receptor agonist, Cl-4AS-1, on breast cancer cells. Endocrine Research, 43(3), 203-214.
Scopus2 Europe PMC12017 Ahram, M., Mustafa, E., Zaza, R., Abu Hammad, S., Alhudhud, M., Bawadi, R., & Zihlif, M. (2017). Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells. Cell Biology International, 41(12), 1345-1355.
Scopus10 Europe PMC62015 Mustafa, E. H., Mahmoud, H. T., Al-Hudhud, M. Y., Abdalla, M. Y., Ahmad, I. M., Yasin, S. R., . . . Tahtamouni, L. H. (2015). 2-deoxy-D-glucose synergizes with doxorubicin or L-buthionine sulfoximine to reduce adhesion and migration of breast cancer cells. Asian Pacific Journal of Cancer Prevention, 16(8), 3213-3222.
Scopus12 Europe PMC42014 Ahram, M., Othman, A., Shahrouri, M., & Mustafa, E. (2014). Factors influencing public participation in biobanking. European Journal of Human Genetics, 22(4), 445-451.
Scopus33 Europe PMC172010 Ahmad, I. M., Mustafa, E. H., Mustafa, N. H., Tahtamouni, L. H., & Abdalla, M. Y. (2010). 2DG enhances the susceptibility of breast cancer cells to doxorubicin. Central European Journal of Biology, 5(6), 739-748.
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Conference Items
Year Citation 2019 Winter, J. M., Mustafa, E. H., Wang, S., Selth, L. A., Hickey, T. E., & Tilley, W. D. (2019). Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro. Poster session presented at the meeting of CANCER RESEARCH. Atlanta, GA: AMER ASSOC CANCER RESEARCH.
Cellular Biochemistry and Physiology Lab Supervisor. Jul. 2013 - June 2017. Teaching the practical part of medical physiology for medical and dental students Dep. of Physiology & Biochemistry- Faculty of Medicine/ University of Jordan.
Lecturer Oct. 2011- Aug. 2012 Teaching theoretical & practical part of general biology, biochemistry, genetics & zoology Dep. of Biology & Biotechnology - Tabuk University/ KSA.
Lecturer Feb. 2010- May. 2011 Teaching practical part of general biology, biochemistry, tissue culture, recombinant DNA, ecology, hematology, genetics, human physiology, animal biology & histology
Dep. of Biology & Biotechnology – Faculty of Science / The Hashemite University.
Student Teaching Assistant Feb. 2008- May. 2010
Coordinated practical sessions of several biology courses
Dep. of Biology & Biotechnology – Faculty of Science / The Hashemite University.
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