Ebtihal Mustafa

Mrs Ebtihal Mustafa

Higher Degree by Research Candidate

PhD Student - DRMCRL

Adelaide Medical School

Faculty of Health and Medical Sciences


 

Estrogen receptor α negative (ER-) breast cancer is an aggressive subtype with limited therapeutic targets. The androgen receptor (AR) is a promising target in ER- disease, but existing preclinical data is inconsistent. Other candidate targets are transcriptional cyclin-dependent kinases 9 (CDK9) due to high rates of transcription characteristics of aggressive disease. However, targeting CDKs has been hampered by the poor selectivity of existing inhibitors. My research work aims to define the mechanisms of AR-regulated proliferation in ER- breast cancer and evaluates the efficacy of novel CDK9 inhibitors with and without AR targeted therapies, to provide preclinical evidence for a new therapeutic strategy.  

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  • Journals

    Year Citation
    2018 Rouibah, H., Kebsa, W., Lahouel, M., Zihlif, M., Ahram, M., Aburmeleih, B., . . . El-Ameer, H. J. (2018). Erratum: Algerian propolis potentiates doxorubicin mediated anticancer effect against human pancreatic PANC-1 cancer cell line through cell cycle arrest, apoptosis induction and P-glycoprotein inhibition (Anti-Cancer Agents in Medicinal Chemistry, (2018) 18, 3, (375), 10.2174/1871520618666180110143239). Anti-Cancer Agents in Medicinal Chemistry, 18(9), 1364.
    DOI
    2018 Kebsa, W., Lahouel, M., Rouibah, H., Zihlif, M., Ahram, M., Abu-Irmaileh, B., . . . Al Shhab, M. (2018). Reversing multidrug resistance in chemo-resistant human lung adenocarcinoma (A549/dox) cells by algerian propolis through direct inhibiting the P-gp Efflux-pump, G0/G1 cell cycle arrest and apoptosis induction. Anti-Cancer Agents in Medicinal Chemistry, 18(9), 1330-1337.
    DOI Scopus5 Europe PMC2
    2018 Rouibah, H., Kebsa, W., Lahouel, M., Zihlif, M., Ahram, M., Aburmeleih, B., . . . El-Amir, H. (2018). Algerian propolis potentiates doxorubicin mediated anticancer effect against human pancreatic panc-1 cancer cell line through cell cycle arrest, apoptosis induction and p-glycoprotein inhibition. Anti-Cancer Agents in Medicinal Chemistry, 18(3), 375-387.
    DOI Scopus3 Europe PMC2
    2018 Ahram, M., Mustafa, E., Abu Hammad, S., Alhudhud, M., Bawadi, R., Tahtamouni, L., . . . Zihlif, M. (2018). The cellular and molecular effects of the androgen receptor agonist, Cl-4AS-1, on breast cancer cells. Endocrine Research, 43(3), 203-214.
    DOI Scopus2 Europe PMC1
    2017 Ahram, M., Mustafa, E., Zaza, R., Abu Hammad, S., Alhudhud, M., Bawadi, R., & Zihlif, M. (2017). Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells. Cell Biology International, 41(12), 1345-1355.
    DOI Scopus10 Europe PMC6
    2015 Mustafa, E. H., Mahmoud, H. T., Al-Hudhud, M. Y., Abdalla, M. Y., Ahmad, I. M., Yasin, S. R., . . . Tahtamouni, L. H. (2015). 2-deoxy-D-glucose synergizes with doxorubicin or L-buthionine sulfoximine to reduce adhesion and migration of breast cancer cells. Asian Pacific Journal of Cancer Prevention, 16(8), 3213-3222.
    DOI Scopus12 Europe PMC4
    2014 Ahram, M., Othman, A., Shahrouri, M., & Mustafa, E. (2014). Factors influencing public participation in biobanking. European Journal of Human Genetics, 22(4), 445-451.
    DOI Scopus33 Europe PMC17
    2010 Ahmad, I. M., Mustafa, E. H., Mustafa, N. H., Tahtamouni, L. H., & Abdalla, M. Y. (2010). 2DG enhances the susceptibility of breast cancer cells to doxorubicin. Central European Journal of Biology, 5(6), 739-748.
    DOI Scopus15
  • Conference Items

    Year Citation
    2019 Winter, J. M., Mustafa, E. H., Wang, S., Selth, L. A., Hickey, T. E., & Tilley, W. D. (2019). Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro. Poster session presented at the meeting of CANCER RESEARCH. Atlanta, GA: AMER ASSOC CANCER RESEARCH.
    DOI

Cellular Biochemistry and Physiology Lab Supervisor. Jul. 2013 - June 2017. Teaching the practical part of medical physiology for medical and dental students Dep. of Physiology & Biochemistry- Faculty of Medicine/ University of Jordan.

Lecturer Oct. 2011- Aug. 2012 Teaching theoretical & practical part of general biology, biochemistry, genetics & zoology Dep. of Biology & Biotechnology - Tabuk University/ KSA. 

Lecturer Feb. 2010- May. 2011 Teaching practical part of general biology, biochemistry, tissue culture, recombinant DNA, ecology, hematology, genetics, human physiology, animal biology & histology
Dep. of Biology & Biotechnology – Faculty of Science / The Hashemite University. 

Student Teaching Assistant Feb. 2008- May. 2010
Coordinated practical sessions of several biology courses
Dep. of Biology & Biotechnology – Faculty of Science / The Hashemite University.

  • Position: PhD Student - DRMCRL
  • Phone: 83136869
  • Email: ebtihal.mustafa@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 8
  • Room: WS8050.10
  • Org Unit: Medical Specialties

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