Duncan Hewett

Dr Duncan Hewett

Postdoctoral Researcher

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Duncan Hewett is a senior postdoctoral scientist in the Myeloma Research Group of Professor Andrew Zannettino. He is located within the Cancer Theme at SAHMRI on North Terrace. Multiple Myeloma is a largely incurable haematological malignancy caused by the clonal expansion differentiated B cells called plasma cells. Research focuses on using cell-based and mouse-based models of multiple myeloma to more fully understand the roles that mutated or dysregulated genes play in cancer initiation and progression, and to test the pre-clinical efficacy of novel anti-myeloma therapeutics. Current projects include: (a) determination of the role of the putative tumour suppressor SAMSN1; (b) characterising the evolving mutational profile of mutant plasma cells as patients progress from pre-malignant conditions to diagnostic multiple myeloma; (c) testing novel therapies directed towards neutralization of cancer-growth promoting bone marrow stromal factors; (d) a molecular dissection of the roles that the TAM receptors play in multiple myeloma cancer cell growth/migration/ immune evasion; (e) characterisation of the putative tumour suppressor SP140; and (f) determination of some novel biological effects of MAF oncogene overexpression.

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor The roles of the Tam Receptor Family in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Justine Rachel Clark
    2017 Co-Supervisor Investigation of the competing effects of the CXCL12/CXCR4 and CCL3/CCR1 chemokine axes in the dissemination and migration of multiple myeloma plasma cells Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 - 2019 Co-Supervisor The Role of SAMSN1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ms Natasha Friend
    2014 - 2018 Co-Supervisor A Genomic Approach Towards an Understanding of Clonal Evolution and Disease Progression in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ankit Kumar Dutta
    2009 - 2013 Co-Supervisor Regulation of BCR-ABL expression via its 3'untranslated region Doctor of Philosophy Doctorate Full Time Mr Bradley Chereda
  • Position: Postdoctoral Researcher
  • Phone: 81284694
  • Email: duncan.hewett@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI, floor 5 South
  • Org Unit: Adelaide Medical School

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