Grant-Funded Researcher B
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Duncan Hewett is a senior postdoctoral scientist in the Myeloma Research Group of Professor Andrew Zannettino. He is located within the Cancer Theme at SAHMRI on North Terrace. Multiple Myeloma is a largely incurable haematological cancer caused by the clonal expansion of differentiated B cells called plasma cells. His research focuses on using cell-based and mouse-based models of multiple myeloma to more fully understand the roles that mutated or dysregulated genes play in cancer initiation and progression, and to test the pre-clinical efficacy of novel anti-myeloma therapeutics.
Current projects include: (a) in vivo genetic screens using CRISPR-Cas9 to identify mechanisms of tumour cell dissemination ; (b) identifying molecular and cellular factors that enable to cancer cells to evade immune surveillance; (c) testing novel therapies directed towards neutralization of cancer-growth promoting bone marrow stromal factors; (d) a molecular dissection of the roles that the TAM receptors play in multiple myeloma cancer cell growth/migration/ immune evasion; (e) characterisation of the role of tumour derived legumain in tumour cell growth and metastasis; (f) development of a lenalidomide-responsive in vivo model of myeloma
Opportunites exist in 2022 for Honours and HDR projects for new students across many of the above projects. Please contact me via email to discuss further and/or arrange a visit to our laboratory located within the Precision Medicine Theme in the South Australian Health and Medical Research Institute (SAHMRI).
Year Citation 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. W. (2017). HIF-2 alpha Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
Year Citation 2019 Zeissig, M. N., Hewett, D. R., Mrozik, K. M., Panagopoulos, V., Engelhardt, M., To, L. B., . . . Vandyke, K. (2019). Therapeutic Targeting of CCR1 to Prevent Dissemination of Multiple Myeloma Plasma Cells. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
Year Citation Dutta, A., Zannettino, A., Hewett, D., & firstname.lastname@example.org. (n.d.). ZANNETTINO_EGA DAA_EGAS00001002850.doc.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 Principal Supervisor Investigating the role of Gremlin1 in driving multiple myeloma cancer development and progression Doctor of Philosophy Doctorate Full Time Miss Emma Anna-Jane Cheney 2020 Principal Supervisor Identification of novel mechanisms that drive the dissemination of multiple myeloma tumour cells Doctor of Philosophy Doctorate Full Time Miss Hayley Bridget Parkinson 2019 Co-Supervisor The roles of the Tam Receptor Family in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Justine Rachel Clark
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2020 Co-Supervisor CCR1 as a Therapeutic Target in Multiple Myeloma: Preventing Tumour Dissemination and Therapeutic Resistance Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig 2015 - 2019 Co-Supervisor The Role of SAMSN1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ms Natasha Friend 2015 - 2020 Co-Supervisor The Role of Gremlin1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mrs Kimberley Claire Clark 2014 - 2018 Co-Supervisor A Genomic Approach Towards an Understanding of Clonal Evolution and Disease Progression in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ankit Kumar Dutta 2009 - 2013 Co-Supervisor Regulation of BCR-ABL expression via its 3'untranslated region Doctor of Philosophy Doctorate Full Time Mr Bradley Chereda
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