Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Duncan Hewett is a senior postdoctoral scientist in the Myeloma Research Group of Professor Andrew Zannettino. He is located within the Cancer Theme at SAHMRI on North Terrace. Multiple Myeloma is a largely incurable haematological malignancy caused by the clonal expansion differentiated B cells called plasma cells. Research focuses on using cell-based and mouse-based models of multiple myeloma to more fully understand the roles that mutated or dysregulated genes play in cancer initiation and progression, and to test the pre-clinical efficacy of novel anti-myeloma therapeutics. Current projects include: (a) determination of the role of the putative tumour suppressor SAMSN1; (b) characterising the evolving mutational profile of mutant plasma cells as patients progress from pre-malignant conditions to diagnostic multiple myeloma; (c) testing novel therapies directed towards neutralization of cancer-growth promoting bone marrow stromal factors; (d) a molecular dissection of the roles that the TAM receptors play in multiple myeloma cancer cell growth/migration/ immune evasion; (e) characterisation of the putative tumour suppressor SP140; and (f) determination of some novel biological effects of MAF oncogene overexpression.
Year Citation 2017 Zeissig, M. N., Hewett, D. R., Martin, S., Mrozik, K. M., Cheong, C. M., Diamond, P., . . . Zannettino, A. C. (2017). HIF-2 alpha Upregulates CCR1 to Promote Dissemination of Plasma Cells in Multiple Myeloma. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
Year Citation — Dutta, A., Zannettino, A., Hewett, D., & email@example.com. (n.d.). ZANNETTINO_EGA DAA_EGAS00001002850.doc.
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor The roles of the Tam Receptor Family in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Miss Justine Rachel Clark 2017 Co-Supervisor Investigation of the competing effects of the CXCL12/CXCR4 and CCL3/CCR1 chemokine axes in the dissemination and migration of multiple myeloma plasma cells Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig 2015 Co-Supervisor Cooperating Genetic Changes that Drive Myeloma Development - The Role of the Samsn 1 and GLIPRI Tumour Suppressor Genes Doctor of Philosophy Doctorate Full Time Ms Natasha Friend
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2014 - 2018 Co-Supervisor A Genomic Approach Towards an Understanding of Clonal Evolution and Disease Progression in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ankit Kumar Dutta 2009 - 2013 Co-Supervisor Regulation of BCR-ABL expression via its 3'untranslated region Doctor of Philosophy Doctorate Full Time Mr Bradley Chereda
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