Duncan Hewett

Dr Duncan Hewett

Grant-Funded Researcher B

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Duncan Hewett is a senior postdoctoral scientist in the Myeloma Research Group of Dr Kate Vandyke. He is located within the Precision Cancer Medicine Theme at SAHMRI on North Terrace. Multiple Myeloma is a largely incurable haematological cancer caused by the clonal expansion of differentiated B cells called plasma cells. His research focuses on using cell-based and mouse-based models of multiple myeloma to more fully understand the roles that mutated or dysregulated genes play in cancer initiation and progression, and to test the pre-clinical efficacy of novel anti-myeloma therapeutics.

Current projects include: (a) the use of in vivo genetic screens using CRISPR-Cas9 and metabolomics to identify previously unknown mechanisms promoting myeloma tumour cell survival within the bone marrow microenvironment; (b) the optimisation of lenalidomide drug responsive mouse models of myeloma to search for new drug synergies and boost host immune responses to tumours. 

Opportunities exist in Semester 1 2025 for Honours and/or HDR projects for new students across many aspects of the above projects. Please contact me via email to discuss further and/or arrange a visit to our laboratory located within the Precision Cancer Medicine Theme in the South Australian Health and Medical Research Institute (SAHMRI).

 

 

 

 

 

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2021 Principal Supervisor Targeting the bone marrow microenvironment: exploring Gremlin1’s role in myeloma-associated macrophages and developing IMiD-sensitive murine models of myeloma Doctor of Philosophy Doctorate Full Time Miss Emma Anna-Jane Cheney
    2020 Principal Supervisor Identification of novel mechanisms that drive the dissemination of multiple myeloma tumour cells Doctor of Philosophy Doctorate Full Time Miss Hayley Bridget Parkinson
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2023 Co-Supervisor The TAM receptor family in multiple myeloma Doctor of Philosophy Doctorate Full Time Miss Justine Rachel Clark
    2017 - 2020 Co-Supervisor CCR1 as a Therapeutic Target in Multiple Myeloma: Preventing Tumour Dissemination and Therapeutic Resistance Doctor of Philosophy Doctorate Full Time Miss Mara Natasha Zeissig
    2015 - 2019 Co-Supervisor The Role of SAMSN1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ms Natasha Friend
    2015 - 2020 Co-Supervisor The Role of Gremlin1 in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Mrs Kimberley Claire Clark
    2014 - 2018 Co-Supervisor A Genomic Approach Towards an Understanding of Clonal Evolution and Disease Progression in Multiple Myeloma Doctor of Philosophy Doctorate Full Time Ankit Kumar Dutta
    2009 - 2013 Co-Supervisor Regulation of BCR-ABL expression via its 3'untranslated region Doctor of Philosophy Doctorate Full Time Mr Bradley Chereda
  • Position: Grant-Funded Researcher B
  • Phone: 81284694
  • Email: duncan.hewett@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI, floor 5 South
  • Org Unit: Medical Sciences

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