Dominik Linz

Dr Dominik Linz

Lecturer

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Dr Dominik Linz is a clinician-scientist who received his PhD from the University of Maastricht, The Netherlands, in 2013. Given his track record, he has been recruited as a senior lecturer and clinical EP-fellow to Adelaide to initiate and drive a translational research program focusing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide.

Research areas and translation: Over the past years Dr Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included (i) Work describing transient apnoea-associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility in sleep apnoea. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrate in diabetes. (iv) Description of antihypertensive effects of pharmacological inhibition NHE3-dependent intestinal sodium absorption. Ongoing research is mainly focused on preventive interventions for AF.

Dr Dominik Linz is a clinician-scientist who received his PhD from the University of Maastricht, The Netherlands, in 2013. Given his track record, he has been recruited as a senior lecturer and clinical EP-fellow to Adelaide to initiate and drive a translational research program focusing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide.

Research areas and translation: Over the past years Dr Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included (i) Work describing transient apnoea-associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility in sleep apnoea. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrate in diabetes. (iv) Description of antihypertensive effects of pharmacological inhibition NHE3-dependent intestinal sodium absorption. Ongoing research is mainly focused on preventive interventions for AF.

Most significant publications past 5 years

1. Linz D, Hohl M, Dhein S, Ruf S, Reil JC, Kabiri M, Wohlfart P, Verheule S, Böhm M, Sadowski T, Schotten U. Cathepsin A Mediates Susceptibility to Atrial Tachyarrhythmia and Impairment of Atrial Emptying Function in Zucker Diabetic Fatty Rats. Cardiovascular Research 2016;110:371-80. Fist description of the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrate in diabetes.

2. Linz D, Linz B, Hohl M, Böhm M. Atrial arrhythmogenesis in obstructive sleep apnoea: Therapeutic implications. Sleep Medicine Reviews 2016;26:87-94. (invited review) Comprehensive invited review of the mechanisms and clinical implications of sleep apnoea in patients with atrial fibrillation in one of the leading internal sleep medicine journals. A reflection of Dr Linz´s international reputation in the field of atraial fibrillation and sleep disordered breathing.

3. Linz D, van Hunnik A, Hohl M, Mahfoud F, Wolf M, Neuberger HR, Casadei B, Reilly SN, Verheule S, Böhm M, Schotten U. Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats. Circulation: Arrhythmia and Electrophysiology 2015;8:466-74. In this study, renal sympathetic denervation by the clinically used catheter resulted in a reduction in atrial fibrillation complexity and reduced neural atrial remodeling in one of the most established animal models for atrial fibrillation.

4. Linz D, Hohl M, Ukena C, Mahfoud F, Wirth K, Neuberger HR, Böhm M. Obstructive respiratory events and premature atrial contractions after cardioversion. European Respiratory Journal 2015;45: 1332-40. In this paper, the influence of acute obstructive respiratory events on the occurrence of premature atrial contractions, representing a potent trigger for atrial fibrillation is investigated.

5. Linz D, Hohl M, Nickel A, Mahfoud F, Wagner M, Ewen S, Schotten U, Maack C, Wirth K, Böhm M. Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnoea. Hypertension 2013;62:767-74. This paper describes a novel pig model for sleep apnoea and atrial fibrillation and provides data on the antiarrhythmic effect of renal sympathetic denervation. Opened the way for prospective randomized studies of atrial fibrillation and renal sympathetic denervation.

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  • Appointments
    Date Position Institution name
    2017 Beacon Research Fellow & Cardiologist University of Adelaide
    2011 - 2017 Cardiologist University Homburg
    2009 - 2011 PhD-Student University of Maastricht

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2015 Award Research Award "Circulation and Sleep" German Society of Sleep Medicine Germany —
    2014 Award Winning moderated poster European Society of Cardiology — —
    2014 Award Juergen Bretschreider poster award German Society of Cardiology — —
    2013 Award Research award "Dr. Albert Buding" German Hypertension Society Germany —
    2012 Award Award for Innervation — Germany —
    2011 Award Young Investigator Award German Hypertension Society Germany —

  • Language Competencies
    Language Competency
    Dutch; Flemish Can read and speak
    English Can read, write, speak, understand spoken and peer review
    German Can read, write, speak, understand spoken and peer review

  • Education
    Date Institution name Country Title
    2013 University of Maastricht The Netherlands PhD
    2009 University Mainz Germany MD

  • Research Interests
    Cardiology
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  • Journals
    Year Citation
    2019 Linz, D., Pitman, B., Kadhim, K., O'shea, C., Mahajan, R., Sanders, P., & Lau, D. (2019). His-Bundle Pacing Post-Atrioventricular Node Ablation: Mapping His-Bundle Potential From “Down Under”. JACC: Clinical Electrophysiology, 5(2), 258-259.
    DOI
    2019 Linz, D., Sanders, P., Pitman, B., Dobrev, D., & Lau, D. (2019). Atrial fibrillation in sub-Saharan Africa: The knowns and unknowns?. IJC Heart and Vasculature, 22, 212-213.
    DOI
    2019 Linz, D., Kalman, J. M., R Doug, M., & Sanders, P. (2019). CPAP initiation in persistent atrial fibrillation: Have we overslept the alarm clock?. International Journal of Cardiology, 278, 144-146.
    DOI
    2018 Mahajan, R., Nelson, A., Pathak, R., Middeldorp, M., Wong, C., Twomey, D., . . . Sanders, P. (2018). Electroanatomical Remodeling of the Atria in Obesity: Impact of Adjacent Epicardial Fat. JACC: Clinical Electrophysiology, 4(12), 1529-1540.
    DOI
    2018 Linz, D., Brooks, A., Elliott, A., Kalman, J., McEvoy, R., Lau, D., & Sanders, P. (2018). Nightly variation in sleep apnea severity as atrial fibrillation risk. Journal of the American College of Cardiology, 72(19), 2406-2407.
    DOI Scopus2 WoS2
    2018 Linz, D., Kadhim, K., Lau, D., & Sanders, P. (2018). Recovery of adenosine-sensitive dormant conduction is but one mechanism of pulmonary vein reconnection. Indian Pacing and Electrophysiology Journal, 18(6), 201-202.
    DOI Europe PMC1
    2018 Mishima, R., Hohl, M., Linz, B., Sanders, P., & Linz, D. (2018). Too Fatty, Too Salty, Too Western. Hypertension (Dallas, Tex. : 1979), 72(5), 1078-1080.
    DOI
    2018 Thomas, D., Christ, T., Fabritz, L., Goette, A., Hammwöhner, M., Heijman, J., . . . Voigt, N. (2018). German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management. Clinical Research in Cardiology.
    DOI Scopus2
    2018 Linz, D., Elliott, A., Hohl, M., Malik, V., Schotten, U., Dobrev, D., . . . Sanders, P. (2018). Role of autonomic nervous system in atrial fibrillation. International Journal of Cardiology.
    DOI Scopus2
    2018 Baumert, M., Immanuel, S. A., Stone, K. L., Litwack Harrison, S., Redline, S., Mariani, S., . . . Linz, D. (2018). Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men. European Heart Journal, Online, 1-9.
    DOI
    2018 Linz, D., Baumert, M., Catcheside, P., Floras, J., Sanders, P., Lévy, P., . . . Doug McEvoy, R. (2018). Assessment and interpretation of sleep disordered breathing severity in cardiology: clinical implications and perspectives. International Journal of Cardiology, 271, 281-288.
    DOI Scopus3 WoS4
    2018 Kadhim, K., Lau, D., Linz, D., & Sanders, P. (2018). Improved survival and reduced stroke risk in patients with atrial fibrillation: Is catheter ablation winning the rhythm-control race?. International Journal of Cardiology, 266, 153-154.
    DOI
    2018 Linz, D., Arzt, M., Sanders, P., & Böhm, M. (2018). Should we treat any sleep apnea in patients with atrial fibrillation?. Clinical Research in Cardiology, 107(11), 987-990.
    DOI Scopus1
    2018 Middeldorp, M., Pathak, R., Meredith, M., Mehta, A., Elliott, A., Mahajan, R., . . . Sanders, P. (2018). PREVEntion and regReSsive effect of weight-loss and risk factor modification on Atrial Fibrillation: The REVERSE-AF study. Europace, 20(12), 1929-1935.
    DOI Scopus11 WoS9 Europe PMC2
    2018 Elliott, A. D., Linz, D., Verdicchio, C. V., & Sanders, P. (2018). Exercise and atrial fibrillation: prevention or causation?. Heart, Lung and Circulation, 27(9), 1078-1085.
    DOI Scopus4 WoS5
    2018 Linz, D., Kadhim, K., Brooks, A., Elliott, A., Hendriks, J., Lau, D., . . . Sanders, P. (2018). Diagnostic accuracy of overnight oximetry for the diagnosis of sleep-disordered breathing in atrial fibrillation patients. International Journal of Cardiology, 272, 155-161.
    DOI
    2018 Agbaedeng, T., Linz, D., Lau, D., & Sanders, P. (2018). Unique role of epicardial adipose tissue in atrial fibrosis: “Atrial remodeling of a new sort”. Heart Rhythm, 15(11), 1728-1729.
    DOI
    2018 Selejan, S., Linz, D., Tatu, A., Hohl, M., Speer, T., Ewen, S., . . . Böhm, M. (2018). Sympathoadrenergic suppression improves heart function by upregulating the ratio of sRAGE/RAGE in hypertension with metabolic syndrome. Journal of Molecular and Cellular Cardiology, 122, 34-46.
    DOI
    2018 Munawar, D., Mahajan, R., Linz, D., Wong, G., Khokhar, K., Thiyagarajah, A., . . . Lau, D. (2018). Predicted longevity of contemporary cardiac implantable electronic devices: a call for industry-wide “standardized” reporting. Heart Rhythm, 15(12), 1756-1763.
    DOI Scopus2 WoS1
    2018 Linz, D., Hohl, M., & Dobrev, D. (2018). Can cystatin C-based estimated glomerular filtration rate help to guide individualized risk factor modification programs?. IJC Heart and Vasculature, 19, 100-101.
    DOI
    2018 Khoshkish, S., Hohl, M., Linz, B., Arzt, M., Mahfoud, F., Baumert, M., . . . Linz, D. (2018). The association between different features of sleep-disordered breathing and blood pressure: A cross-sectional study. Journal of clinical hypertension (Greenwich, Conn.), 20(3), 575-581.
    DOI Scopus1 WoS1
    2018 Linz, D., Colling, S., Nußstein, W., Debl, K., Hohl, M., Fellner, C., . . . Arzt, M. (2018). Nocturnal hypoxemic burden is associated with epicardial fat volume in patients with acute myocardial infarction. Sleep and Breathing, 22(3), 703-711.
    DOI Scopus2 WoS1
    2018 Sanders, P., Mishima, R., Linz, D., & Lau, D. (2018). In search of atrial fibrillation driver sites: is temporally stable frequency mapping a new armamentarium?. Journal of Cardiovascular Electrophysiology, 29(4), 523-525.
    DOI Scopus1 WoS1 Europe PMC1
    2018 Linz, D., Hohl, M., Elliott, A., Lau, D., Mahfoud, F., Esler, M., . . . Böhm, M. (2018). Modulation of renal sympathetic innervation: recent insights beyond blood pressure control. Clinical Autonomic Research, 28(4), 375-384.
    DOI Scopus6 WoS2 Europe PMC2
    2018 Mishima, R., Elliott, A., Sanders, P., & Linz, D. (2018). Microbiome and atrial fibrillation. International Journal of Cardiology, 255, 103-104.
    DOI Scopus2 WoS2
    2018 Wells, R., Spurrier, A., Linz, D., Gallagher, C., Mahajan, R., Sanders, P., . . . Lau, D. (2018). Postural tachycardia syndrome: Current perspectives. Vascular Health and Risk Management, 14, 1-11.
    DOI Scopus4 Europe PMC2
    2018 Linz, D., McEvoy, R., Cowie, M., Somers, V., Nattel, S., Lévy, P., . . . Sanders, P. (2018). Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: a review. JAMA cardiology, 3(6), 532-540.
    DOI Scopus20 WoS18 Europe PMC8
    2018 Lauder, L., Ewen, S., Tzafriri, A., Edelman, E., Cremers, B., Kulenthiran, S., . . . Mahfoud, F. (2018). Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. Cardiovascular Revascularization Medicine, 19(7), 845-851.
    DOI Scopus1 Europe PMC1
    2018 Kosiuk, J., de Potter, T., & Linz, D. (2018). The role of electroanatomical mapping in individualized treatment of paroxysmal atrial fibrillation. International Journal of Cardiology, 259, 105-106.
    DOI
    2018 Desteghe, L., Hendriks, J., McEvoy, R., Chai-Coetzer, C., Dendale, P., Sanders, P., . . . Linz, D. (2018). The why, when and how to test for obstructive sleep apnea in patients with atrial fibrillation. Clinical research in cardiology : official journal of the German Cardiac Society, 107(8), 617-631.
    DOI Scopus8 WoS5 Europe PMC2
    2018 Linz, D., Nalliah, C., Kalman, J., & Sanders, P. (2018). Routine screening for sleep apnea in patients with atrial fibrillation: Ready for primetime?. International Journal of Cardiology, 260, 103-104.
    DOI
    2018 Elliott, A., Mahajan, R., Linz, D., Stokes, M., Verdicchio, C., Middeldorp, M., . . . Sanders, P. (2018). Atrial remodeling and ectopic burden in recreational athletes: Implications for risk of atrial fibrillation.. Clinical cardiology, 41(6), 843-848.
    DOI Scopus4 WoS4 Europe PMC3
    2018 Noels, H., Boor, P., Goettsch, C., Hohl, M., Jahnen-Dechent, W., Jankowski, V., . . . Jankowski, J. (2018). The new SFB/TRR219 Research Centre. European Heart Journal, 39(12), 975-977.
    DOI
    2017 Linz, B., Böhm, M., & Linz, D. (2017). Update: Cardiovascular Sleep Medicine. Deutsche Medizinische Wochenschrift, 142(12), 912-923.
    DOI
    2017 Lau, D., Thiyagarajah, A., Willems, S., Rostock, T., Linz, D., Stiles, M., . . . Sanders, P. (2017). Device therapy for rate control: pacing, resynchronisation and AV node ablation. Heart, Lung and Circulation, 26(9), 934-940.
    DOI Scopus4 WoS3 Europe PMC3
    2017 Thanigaimani, S., McLennan, E., Linz, D., Mahajan, R., Agbaedeng, T., Lee, G., . . . Lau, D. (2017). Progression and reversibility of stretch induced atrial remodeling: Characterization and clinical implications. Progress in Biophysics and Molecular Biology, 130(Pt B), 376-386.
    DOI Scopus6 WoS5 Europe PMC3
    2017 Hohl, M., Lau, D., Müller, A., Elliott, A., Linz, B., Mahajan, R., . . . Linz, D. (2017). Concomitant obesity and metabolic syndrome add to the atrial arrhythmogenic phenotype in male hypertensive rats. Journal of the American Heart Association, 6(9), 1-12.
    DOI Scopus12 WoS11 Europe PMC7
    2017 Linz, D., Elliott, A., Marwick, T., & Sanders, P. (2017). Biomarkers and new-onset atrial fibrillation to assess atrial cardiomyopathy. International Journal of Cardiology, 248, 208-210.
    DOI Scopus1 WoS1 Europe PMC1
    2017 Kindermann, I., Wedegärtner, S., Mahfoud, F., Weil, J., Brilakis, N., Ukena, J., . . . Böhm, M. (2017). Improvement in health-related quality of life after renal sympathetic denervation in real-world hypertensive patients: 12-month outcomes in the Global SYMPLICITY Registry. Journal of Clinical Hypertension, 19(9), 833-839.
    DOI Scopus2 WoS1
    2017 Kosiuk, J., Linz, D., & Hindricks, G. (2017). Letter by Kosiuk et al regarding article, "effect of aggressive blood pressure control on the recurrence of atrial fibrillation after catheter ablation: A randomized, open label clinical trial (SMAC-AF [substrate modification with aggressive blood pressure control])". Circulation, 136(13), 1267-1268.
    DOI
    2017 Mishima, R., Elliott, A., Sanders, P., & Linz, D. (2017). Gastrointestinal sodium absorption, microbiome, and hypertension. Nature Reviews Cardiology, 14(11), 693.
    DOI Scopus2 WoS3
    2017 Sanders, P., Elliott, A., & Linz, D. (2017). Upstream targets to treat atrial fibrillation. Journal of the American College of Cardiology, 70(23), 2906-2908.
    DOI Scopus2 WoS2 Europe PMC1
    2017 Mahfoud, F., Boyce Moon, L., Pipenhagen, C., Jensen, J., Pathak, A., Papademetriou, V., . . . Bohm, M. (2017). Reply. Journal of Hypertension, 35(1), 200.
    DOI
    2017 Lau, D., Linz, D., Schotten, U., Mahajan, R., Sanders, P., & Kalman, J. (2017). Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis. Heart Lung and Circulation, Online(9), 1-7.
    DOI Scopus21 WoS19 Europe PMC10
    2017 Linz, D., Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L., Schlaich, M., . . . Bohm, M. (2017). Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: Results from the Global SYMPLICITY Registry. Journal of Hypertension, 35(1), 148-153.
    DOI Scopus7 WoS7 Europe PMC6
    2017 Linz, D., Hohl, M., Vollmar, J., Ukena, C., Mahfoud, F., & Böhm, M. (2017). Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction. Europace, 19(1), 16-20.
    DOI Scopus6 WoS9 Europe PMC6
    2017 Spronk, H., De Jong, A., Verheule, S., De Boer, H., Maass, A., Lau, D., . . . Schotten, U. (2017). Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European Heart Journal, 38(1), 38-50.
    DOI Scopus43 WoS36 Europe PMC27
    2016 Linz, D., Denner, A., Illing, S., Hohl, M., Ukena, C., Mahfoud, F., . . . Böhm, M. (2016). Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs. Clinical Research in Cardiology, 105(8), 639-647.
    DOI Scopus9 WoS6 Europe PMC5
    2016 Linz, D. (2016). Electrical baroreflex stimulation to treat atrial fibrillation: More complex than expected. Heart Rhythm, 13(11), 2213-2214.
    DOI
    2016 Reil, J., Tauchnitz, M., Tian, Q., Hohl, M., Linz, D., Oberhofer, M., . . . Lipp, P. (2016). Hyperaldosteronism induces left atrial systolic and diastolic dysfunction. American Journal of Physiology - Heart and Circulatory Physiology, 311(4), H1014-H1023.
    DOI Scopus3 WoS3 Europe PMC1
    2016 Petrera, A., Kern, U., Linz, D., Gomez-Auli, A., Hohl, M., Gassenhuber, J., . . . Schilling, O. (2016). Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response. Journal of Proteome Research, 15(9), 3188-3195.
    DOI Scopus6 WoS4 Europe PMC3
    2016 Linz, D., Hohl, M., Khoshkish, S., Mahfoud, F., Ukena, C., Neuberger, H., . . . BÖHM, M. (2016). Low-Level But Not High-Level Baroreceptor Stimulation Inhibits Atrial Fibrillation in a Pig Model of Sleep Apnea. Journal of Cardiovascular Electrophysiology, 27(9), 1086-1092.
    DOI Scopus15 WoS11 Europe PMC8
    2016 Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J., Kabiri, M., . . . Schotten, U. (2016). Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovascular Research, 110(3), 371-380.
    DOI Scopus9 WoS9 Europe PMC7
    2016 Linz, D. (2016). Apnoea-associated intrathoracic pressure swings create a dynamic arrhythmogenic atrial substrate during sleep. Europace, 18(3), 469.
    DOI Scopus1 WoS2 Europe PMC1
    2016 Linz, B., Hohl, M., Reil, J., Böhm, M., & Linz, D. (2016). Inhibition of NHE3-mediated sodium absorption in the gut reduced cardiac end-organ damage without deteriorating renal function in obese spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 67(3), 225-231.
    DOI Scopus4 WoS3 Europe PMC3
    2016 Haase, N., Golic, M., Herse, F., Rugor, J., Linz, D., Solano, M., . . . Dechend, R. (2016). Relaxin treatment in an Ang-II-based transgenic preeclamptic-rat model. PLoS ONE, 11(3), 1-11.
    DOI Scopus5 WoS4 Europe PMC3
    2016 Linz, D., Fox, H., Bitter, T., Spießhöfer, J., Schöbel, C., Skobel, E., . . . Oldenburg, O. (2016). Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies. Clinical Research in Cardiology, 105(7), 563-570.
    DOI Scopus24 WoS24 Europe PMC16
    2016 Ripplinger, C., Noujaim, S., & Linz, D. (2016). The nervous heart. Progress in Biophysics and Molecular Biology, 120(1-3), 199-209.
    DOI Scopus19 WoS16 Europe PMC11
    2016 Ukena, C., Mahfoud, F., Ewen, S., Bollmann, A., Hindricks, G., Hoffmann, B., . . . Steinberg, J. (2016). Renal denervation for treatment of ventricular arrhythmias: data from an International Multicenter Registry. Clinical Research in Cardiology, 105(10), 873-879.
    DOI Scopus19 WoS15 Europe PMC8
    2016 Linz, D., Linz, B., Hohl, M., & Böhm, M. (2016). Atrial arrhythmogenesis in obstructive sleep apnea: therapeutic implications. Sleep Medicine Reviews, 26, 87-94.
    DOI Scopus35 WoS34 Europe PMC21
    2016 Zattara, E., Busey, H., Linz, D., Tomoyasu, Y., & Moczek, A. (2016). Neofunctionalization of embryonic head patterning genes facilitates the positioning of novel traits on the dorsal head of adult beetles.. Proceedings. Biological sciences, 283(1834), 20160824.
    DOI WoS3 Europe PMC2
    2016 Mahfoud, F., Moon, L., Pipenhagen, C., Jensen, J., Pathak, A., Papademetriou, V., . . . Böhm, M. (2016). Catheter-based radio-frequency renal nerve denervation lowers blood pressure in obese hypertensive swine model. Journal of Hypertension, 34(9), 1854-1862.
    DOI Scopus9 WoS9 Europe PMC6
    2016 Böhm, M., Ukena, C., Ewen, S., Linz, D., Zivanovic, I., Hoppe, U., . . . Mahfoud, F. (2016). Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension: 12-month outcomes fromthe global SYMPLICITY registry. Journal of Hypertension, 34(12), 2480-2486.
    DOI Scopus12 WoS12 Europe PMC5
    2016 Hohl, M., Linz, D., Fries, P., Mueller, A., Stroeder, J., Urban, D., . . . Mahfoud, F. (2016). Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats. Journal of Translational Medicine, 14(1), 167-1-167-11.
    DOI Scopus4 WoS4 Europe PMC4
    2015 Mahfoud, F., Linz, D., Mancia, G., Narkiewicz, K., Ruilope, L., Schlaich, M., . . . Boehm, M. (2015). RENAL ARTERY DENERVATION FOR TREATMENT OF HYPERTENSIVE PATIENTS WITH OR WITHOUT OBSTRUCTIVE SLEEP APNEA AND RESISTANT HYPERTENSION: RESULTS FROM THE GLOBAL SYMPLICITY REGISTRY. JOURNAL OF HYPERTENSION, 33, E108.
    DOI WoS1
    2015 Schirmer, S., Linz, D., Mahfoud, F., & Böhm, M. (2015). Reply: Sympathetic and Autonomic Effects of Renal Denervation on Atrial Remodeling and Atrial Arrhythmias. JACC: Cardiovascular Interventions, 8(12), 1638-1639.
    DOI Scopus2
    2015 Mahfoud, F., Tunev, S., Ewen, S., Cremers, B., Ruwart, J., Schulz-Jander, D., . . . Melder, R. (2015). Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation. Journal of the American College of Cardiology, 66(16), 1766-1775.
    DOI Scopus67 WoS65 Europe PMC46
    2015 Linz, D., Woehrle, H., Bitter, T., Fox, H., Cowie, M., Böhm, M., & Oldenburg, O. (2015). The importance of sleep-disordered breathing in cardiovascular disease. Clinical Research in Cardiology, 104(9), 705-718.
    DOI Scopus57 WoS57 Europe PMC37
    2015 Linz, D., & Arzt, M. (2015). Sleep-disordered breathing and cardiac disease. Deutsche Medizinische Wochenschrift, 140(17), 1272-1277.
    DOI Scopus1 WoS1
    2015 Böhm, M., Schumacher, H., Linz, D., Reil, J., Ukena, C., Lonn, E., . . . Yusuf, S. (2015). Low resting heart rates are associated with new-onset atrial fibrillation in patients with vascular disease: Results of the ONTARGET/TRANSCEND studies. Journal of Internal Medicine, 278(3), 303-312.
    DOI Scopus6 WoS6 Europe PMC2
    2015 Pöss, J., Ewen, S., Schmieder, R., Muhler, S., Vonend, O., Ott, C., . . . Mahfoud, F. (2015). Effects of renal sympathetic denervation on urinary sodium excretion in patients with resistant hypertension. Clinical Research in Cardiology, 104(8), 672-678.
    DOI Scopus21 WoS22 Europe PMC18
    2015 Ewen, S., Ukena, C., Linz, D., Kindermann, I., Cremers, B., Laufs, U., . . . Mahfoud, F. (2015). Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension. Hypertension, 65(1), 193-199.
    DOI Scopus67 WoS68 Europe PMC45
    2015 Schirmer, S., Sayed, M., Reil, J., Lavall, D., Ukena, C., Linz, D., . . . Böhm, M. (2015). Atrial Remodeling Following Catheter-Based Renal Denervation Occurs in a Blood Pressure- and Heart Rate-Independent Manner. JACC: Cardiovascular Interventions, 8(7), 972-980.
    DOI Scopus20 WoS17 Europe PMC10
    2015 Donazzan, L., Ewen, S., Papademetriou, V., Linicus, Y., Linz, D., Böhm, M., & Mahfoud, F. (2015). Drug therapy for the patient with resistant hypertension. Future Cardiology, 11(2), 191-202.
    DOI
    2015 Linz, D., Van Hunnik, A., Hohl, M., Mahfoud, F., Wolf, M., Neuberger, H., . . . Schotten, U. (2015). Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats. Circulation: Arrhythmia and Electrophysiology, 8(2), 466-474.
    DOI Scopus37 WoS29 Europe PMC23
    2015 Linz, D., Hohl, M., Ukena, C., Mahfoud, F., Wirth, K., Neuberger, H., & Böhm, M. (2015). Obstructive respiratory events and premature atrial contractions after cardioversion. European Respiratory Journal, 45(5), 1332-1340.
    DOI Scopus17 WoS14 Europe PMC10
    2015 Böhm, M., Schumacher, H., Schmieder, R., Mann, J., Teo, K., Lonn, E., . . . Yusuf, S. (2015). Resting heart rate is associated with renal disease outcomes in patients with vascular disease: Results of the ONTARGET and TRANSCEND studies. Journal of Internal Medicine, 278(1), 38-49.
    DOI Scopus13 WoS15 Europe PMC8
    2015 Dörr, O., Ewen, S., Liebetrau, C., Möllmann, H., Gaede, L., Linz, D., . . . Nef, H. (2015). Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation. Clinical Research in Cardiology, 104(12), 1064-1071.
    DOI Scopus7 WoS8 Europe PMC8
    2015 Ewen, S., Meyer, M., Cremers, B., Laufs, U., Helfer, A., Linz, D., . . . Mahfoud, F. (2015). Blood pressure reductions following catheter-based renal denervation are not related to improvements in adherence to antihypertensive drugs measured by urine/plasma toxicological analysis. Clinical Research in Cardiology, 104(12), 1097-1105.
    DOI Scopus44 WoS41 Europe PMC34
    2015 Ewen, S., Dörr, O., Ukena, C., Linz, D., Cremers, B., Laufs, U., . . . Mahfoud, F. (2015). Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension. Journal of Hypertension, 33(12), 2512-2518.
    DOI Scopus14 WoS13 Europe PMC9
    2015 Linz, D., Hohl, M., Schütze, J., Mahfoud, F., Speer, T., Linz, B., . . . Böhm, M. (2015). Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: The role of renal sympathetic innervation. American Journal of Hypertension, 28(2), 256-265.
    DOI Scopus35 WoS36 Europe PMC28
    2014 Böhm, M., Linz, D., Ukena, C., Esler, M., & Mahfoud, F. (2014). Renal denervation for the treatment of cardiovascular high risk-hypertension or beyond?. Circulation Research, 115(3), 400-409.
    DOI Scopus45 WoS40 Europe PMC37
    2014 Linz, D., van Hunnik, A., Ukena, C., Ewen, S., Mahfoud, F., Schirmer, S., . . . Böhm, M. (2014). Renal denervation: effects on atrial electrophysiology and arrhythmias. Clinical Research in Cardiology, 103(10), 765-774.
    DOI Scopus24 WoS23 Europe PMC19
    2014 Hohl, M., Linz, B., Böhm, M., & Linz, D. (2014). Obstructive sleep apnea and atrial arrhythmogenesis. Current Cardiology Reviews, 10(4), 362-368.
    DOI Scopus11 Europe PMC6
    2014 Ewen, S., Ukena, C., Pöss, J., Linz, D., Böhm, M., & Mahfoud, F. (2014). Interventional hypertension therapy in diabetes mellitus. Effects on blood pressure and glucose metabolism?. Herz, 39(3), 325-330.
    DOI
    2014 Böhm, M., Ewen, S., Kindermann, I., Linz, D., Ukena, C., & Mahfoud, F. (2014). Renal denervation and heart failure. European Journal of Heart Failure, 16(6), 608-613.
    DOI Scopus34 WoS29 Europe PMC26
    2014 Mahfoud, F., Urban, D., Teller, D., Linz, D., Stawowy, P., Hassel, J., . . . Kelle, S. (2014). Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: Data from a multi-centre cardiovascular magnetic resonance imaging trial. European Heart Journal, 35(33), 2224-2231.
    DOI Scopus83 WoS79 Europe PMC61
    2014 Linz, D., Mahfoud, F., Linz, B., Hohl, M., Schirmer, S., Wirth, K., & Böhm, M. (2014). Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea. American Journal of Hypertension, 27(10), 1293-1300.
    DOI Scopus28 WoS29 Europe PMC19
    2014 Donazzan, L., Mahfoud, F., Linz, D., Ewen, S., Ukena, C., & Böhm, M. (2014). Novel and nonpharmacologic approaches to cardio-protection in hypertension. Current Hypertension Reports, 16(5), 430-1-430-9.
    DOI Scopus3 WoS3 Europe PMC2
    2014 Böhm, M., Ewen, S., Linz, D., Reil, J., Schirmer, S., Ukena, C., & Mahfoud, F. (2014). Renal denervation: A novel non-pharmacological approach in heart failure. Journal of Cardiovascular Translational Research, 7(3), 330-337.
    DOI Scopus5 WoS5 Europe PMC5
    2014 Schirmer, S., Sayed, M., Reil, J., Ukena, C., Linz, D., Kindermann, M., . . . Böhm, M. (2014). Improvements in left ventricular hypertrophy and diastolic function following renal denervation: Effects beyond blood pressure and heart rate reduction. Journal of the American College of Cardiology, 63(18), 1916-1923.
    DOI Scopus77 WoS64 Europe PMC45
    2014 Ewen, S., Mahfoud, F., Linz, D., Pöss, J., Cremers, B., Kindermann, I., . . . Böhm, M. (2014). Effects of renal sympathetic denervation on exercise blood pressure, heart rate, and capacity in patients with resistant hypertension. Hypertension, 63(4), 839-845.
    DOI Scopus19 WoS21 Europe PMC19
    2014 Hohl, M., Ardehali, H., Azuaje, F., Breckenridge, R., Doehner, W., Eaton, P., . . . Maack, C. (2014). Meeting highlights from the 2013 European society of cardiology heart failure association winter meeting on translational heart failure research. European Journal of Heart Failure, 16(1), 6-14.
    DOI
    2014 Linz, D., Ukena, C., & Neuberger, H. (2014). Treatment of obstructive sleep apnoea improves metabolic conditions and prevents initiation of antiarrhythmic therapy in a patient with atrial fibrillation. Europace, 16(2), 245.
    DOI Scopus1 Europe PMC1
    2014 Linz, D., Ukena, C., Wolf, M., Linz, B., Mahfoud, F., & Böhm, M. (2014). Experimental evidence of the role of renal sympathetic denervation for treating atrial fibrillation. Journal of Atrial Fibrillation, 7(3), 50-53.
    Scopus1
    2014 Linz, D., Ukena, C., Mahfoud, F., Neuberger, H., & Böhm, M. (2014). Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?. Journal of the American College of Cardiology, 63(3), 215-224.
    DOI Scopus65 WoS55 Europe PMC43
    2014 Linz, D., Van Hunnik, A., Ukena, C., Mahfoud, F., Ewen, S., Verheule, S., . . . Schotten, U. (2014). Effects of renal denervation on atrial arrhythmogenesis. Future Cardiology, 10(6), 813-822.
    DOI Scopus4 Europe PMC2
    2014 Linz, D., Ukena, C., Wolf, M., Linz, B., Mahfoud, F., & Böhm, M. (2014). Experimental Evidence Of The Role Of Renal Sympathetic Denervation For Treating Atrial Fibrillation.. Journal of atrial fibrillation, 7(3), 1128.
    DOI Europe PMC1
    2014 Mahfoud, F., Tunev, S., Ruwart, J., Schulz-Jander, D., Cremers, B., Linz, D., . . . Guzman, L. (2014). Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries. Circulation: Cardiovascular Interventions, 7(6), 813-820.
    DOI Scopus7 WoS7 Europe PMC7
    2014 Linz, D., Ukena, C., Esler, M., Böhm, M., & Mahfoud, F. (2014). Response to letter regarding article, "renal denervation for the treatment of cardiovascular high risk-hypertension or beyond?". Circulation Research, 115(7), e19-e20.
    DOI
    2014 Linz, D., & Böhm, M. (2014). Renal denervation for treatment of hypertension and beyond. Clinical Research in Cardiology, 104(1), 87-88.
    DOI Scopus6 WoS6 Europe PMC5
    2014 Verheule, S., Eckstein, J., Linz, D., Maesen, B., Bidar, E., Gharaviri, A., & Schotten, U. (2014). Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation. Progress in Biophysics and Molecular Biology, 115(2-3), 173-185.
    DOI Scopus39 WoS36 Europe PMC30
    2014 Brinkmann, O., Schmerbach, K., Tietge, U., Dietrich, T., Guski, H., Linz, D., . . . Wilfert, K. (2014). Changes in arterial function in a mouse model of human familial hypercholesterolaemia. Acta Physiologica, 211(1), 61-72.
    DOI WoS3 Europe PMC2
    2014 Mahfoud, F., Linz, D., & Böhm, M. (2014). Catheter-based renal denervation: treating hypertension or beyond?. Chinese Medical Journal, 127(6), 1166-1169.
    DOI
    2013 Eckstein, J., Zeemering, S., Linz, D., Maesen, B., Verheule, S., Van Hunnik, A., . . . Schotten, U. (2013). Transmural conduction is the predominant mechanism of breakthrough during atrial fibrillation: Evidence from simultaneous endo-epicardial high-density activation mapping. Circulation: Arrhythmia and Electrophysiology, 6(2), 334-341.
    DOI Scopus83 WoS78 Europe PMC70
    2013 Urban, D., Ewen, S., Ukena, C., Linz, D., Böhm, M., & Mahfoud, F. (2013). Treating resistant hypertension: Role of renal denervation. Integrated Blood Pressure Control, 6, 119-128.
    DOI Scopus9 Europe PMC7
    2013 Wohlfart, P., Linz, W., Hübschle, T., Linz, D., Huber, J., Hess, S., . . . Ruetten, H. (2013). Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies. Journal of Translational Medicine, 11(1), 12 pages.
    DOI Scopus44 WoS40 Europe PMC34
    2013 Lenski, M., Mahfoud, F., Razouk, A., Ukena, C., Lenski, D., Barth, C., . . . Böhm, M. (2013). Orthostatic function after renal sympathetic denervation in patients with resistant hypertension. International Journal of Cardiology, 169(6), 418-424.
    DOI Scopus17 WoS17 Europe PMC12
    2013 Böhm, M., Linz, D., Urban, D., Mahfoud, F., & Ukena, C. (2013). Renal sympathetic denervation: Applications in hypertension and beyond. Nature Reviews Cardiology, 10(8), 465-476.
    DOI Scopus40 WoS37 Europe PMC37
    2013 Linz, D., Wirth, K., Ukena, C., Mahfoud, F., Pöss, J., Linz, B., . . . Neuberger, H. (2013). Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs. Heart Rhythm, 10(10), 1525-1530.
    DOI Scopus88 WoS77 Europe PMC68
    2013 Ukena, C., Mahfoud, F., Spies, A., Kindermann, I., Linz, D., Cremers, B., . . . Böhm, M. (2013). Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension. International Journal of Cardiology, 167(6), 2846-2851.
    DOI Scopus88 WoS67 Europe PMC54
    2013 Linz, D., Mahfoud, F., Ewen, S., Schirmer, S., Reil, J., Ukena, C., & Böhm, M. (2013). Application in hypertension of renal sympathetic denervation - a review. Interventional Cardiology (London), 8(2), 124-126.
    DOI
    2013 Ruf, S., Buning, C., Schreuder, H., Linz, W., Hübschle, T., Linz, D., . . . Sadowski, T. (2013). Inhibition of CatA: An emerging strategy for the treatment of heart failure. Future Medicinal Chemistry, 5(4), 399-409.
    DOI Scopus8 WoS8 Europe PMC6
    2013 Ukena, C., Mahfoud, F., Linz, D., Böhm, M., & Neuberger, H. (2013). Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias. EuroIntervention, 9(R), 110-116.
    DOI Scopus19 WoS14 Europe PMC11
    2013 Mahfoud, F., Ewen, S., Ukena, C., Linz, D., Sobotka, P., Cremers, B., & Böhm, M. (2013). Expanding the indication spectrum: Renal denervation in diabetes. EuroIntervention, 9(R), 117-121.
    DOI Scopus12 WoS9 Europe PMC5
    2013 Böhm, M., Ewen, S., Linz, D., Reil, J., Schirmer, S., Ukena, C., & Mahfoud, F. (2013). Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure. EuroIntervention, 9(R), R122-R126.
    DOI Scopus8 WoS7 Europe PMC4
    2013 Ewen, S., Ukena, C., Linz, D., Schmieder, R., Böhm, M., & Mahfoud, F. (2013). The sympathetic nervous system in chronic kidney disease. Current Hypertension Reports, 15(4), 370-376.
    DOI Scopus20 WoS13 Europe PMC10
    2013 Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Hohl, M., Neuberger, H., . . . Böhm, M. (2013). Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation. Hypertension, 61(1), 225-231.
    DOI Scopus83 WoS69 Europe PMC63
    2013 Mahfoud, F., Linz, D., & Böhm, M. (2013). Heart and kidneys: Renal denervation as therapy for hypertension. Herz, 38(1), 67-78.
    DOI Scopus2 WoS1 Europe PMC1
    2013 Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Neuberger, H., Wirth, K., & Böhm, M. (2013). Effects of electrical stimulation of carotid baroreflex and renal denervation on atrial electrophysiology. Journal of Cardiovascular Electrophysiology, 24(9), 1028-1033.
    DOI Scopus29 WoS25 Europe PMC18
    2013 Linz, D., Hohl, M., Nickel, A., Mahfoud, F., Wagner, M., Ewen, S., . . . Böhm, M. (2013). Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea. Hypertension, 62(4), 767-774.
    DOI Scopus72 WoS71 Europe PMC60
    2013 Linz, D., & Neuberger, H. (2013). Does renal denervation target the substrate or the trigger for ventricular arrhythmias?. Journal of Cardiovascular Electrophysiology, 24(12), E20.
    DOI Scopus2 WoS1 Europe PMC1
    2012 Linz, D., Wirth, K., Linz, W., Heuer, H., Frick, W., Hofmeister, A., . . . Ruetten, H. (2012). Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-Mediated sodium absorption in the gut. Hypertension, 60(6), 1560-1567.
    DOI Scopus35 WoS29 Europe PMC25
    2012 Linz, D., & Neuberger, H. (2012). Chronic kidney disease and atrial fibrillation. Heart Rhythm, 9(12), 2032-2033.
    DOI Scopus3 WoS4 Europe PMC4
    2012 Ruf, S., Buning, C., Schreuder, H., Horstick, G., Linz, W., Olpp, T., . . . Sadowski, T. (2012). Novel β-amino acid derivatives as inhibitors of cathepsin A. Journal of Medicinal Chemistry, 55(17), 7636-7649.
    DOI Scopus26 Europe PMC9
    2012 Linz, D., & Neuberger, H. (2012). Obstructive sleep apnea: The suffocated atrium?. Heart Rhythm, 9(3), 328-329.
    DOI Scopus2 WoS2 Europe PMC1
    2012 Linz, D., Hohl, M., Mahfoud, F., Reil, J., Linz, W., Hübschle, T., . . . Böhm, M. (2012). Cardiac remodeling and myocardial dysfunction in obese spontaneously hypertensive rats. Journal of Translational Medicine, 10(1), 187-1-187-10.
    DOI Scopus13 WoS11 Europe PMC9
    2012 Linz, D., Mahfoud, F., Schotten, U., Ukena, C., Neuberger, H., Wirth, K., & Böhm, M. (2012). Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fibrillation in a model for sleep apnea. Hypertension, 60(1), 172-178.
    DOI Scopus143 WoS130 Europe PMC107
    2012 Mahfoud, F., Cremers, B., Janker, J., Link, B., Vonend, O., Ukena, C., . . . Böhm, M. (2012). Renal hemodynamics and renal function after catheter-based renal sympathetic denervation in patients with resistant hypertension. Hypertension, 60(2), 419-424.
    DOI Scopus229 WoS205 Europe PMC160
    2012 Linz, D. (2012). Atrial fibrillation in obstructive sleep apnea: Atrial arrhythmogenic substrate of a different sort. American Journal of Cardiology, 110(7), 1071.
    DOI Scopus6 WoS8 Europe PMC4
    2012 Daniels, A., Linz, D., Van Bilsen, M., Rütten, H., Sadowski, T., Ruf, S., . . . Van Nieuwenhoven, F. (2012). Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats. European Journal of Heart Failure, 14(2), 193-201.
    DOI Scopus36 WoS33 Europe PMC27
    2012 Linz, D., & Wirth, K. (2012). Intrathoracic pressure oscillations during obstructive apneas disturb ventricular repolarisation. European Journal of Applied Physiology, 112(12), 4181.
    DOI
    2011 Eckstein, J., Maesen, B., Linz, D., Zeemering, S., Van Hunnik, A., Verheule, S., . . . Schotten, U. (2011). Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat. Cardiovascular Research, 89(4), 816-824.
    DOI Scopus86 WoS77 Europe PMC64
    2011 Linz, D., Schotten, U., Neuberger, H., Böhm, M., & Wirth, K. (2011). Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation. Heart Rhythm, 8(9), 1436-1443.
    DOI Scopus110 WoS101 Europe PMC89
    2011 Linz, D., Schotten, U., Neuberger, H., Böhm, M., & Wirth, K. (2011). Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea. Heart Rhythm, 8(12), 1933-1939.
    DOI Scopus23 WoS24 Europe PMC19
    2011 Linz, D., Schmidt, J., Zimmermann, S., Dauer, M., Lammert, F., & Böhm, M. (2011). Cardiovascular diseases: Consequences for the gastrointestinal tract. Gastroenterologe, 6(4), 292-299.
    DOI
    2007 Linz, D., Afkham, F., Itter, G., Rütten, H., & Wirth, K. (2007). Effect of atrial electrical remodeling on the efficacy of antiarrhythmic drugs: Comparison of amiodarone with I<inf>Kr</inf>- and I<inf>to</inf>/IKur- blockade in vivo. Journal of Cardiovascular Electrophysiology, 18(12), 1313-1320.
    DOI Scopus24 WoS20 Europe PMC16
    2007 Wirth, K., Brendel, J., Steinmeyer, K., Linz, D., Rütten, H., & Gögelein, H. (2007). In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. Journal of Cardiovascular Pharmacology, 49(4), 197-206.
    DOI Scopus42 WoS37 Europe PMC30

  • Book Chapters
    Year Citation
    2015 Böhm, M., Linz, D., Ukena, C., & Mahfoud, F. (2015). Pathophysiology: The target for renal denervation. In Renal Denervation: A New Approach to Treatment of Resistant Hypertension (pp. 1-7).
    DOI Scopus1

  • Conference Papers
    Year Citation
    2018 Dederer, J., Selejan, S. -R., Linz, D., Hohl, M., Kazakov, A., Zamyatkin, O., . . . Boehm, M. (2018). Effects of renal denervation on hepatic steatosis and expression of liver RAGE in obese spontaneously hypertensive rats. In INTERNIST Vol. 59 (pp. S47-S48). SPRINGER.
    2017 Linz, D., Hohl, M., Linz, B., Nickel, A., Maack, C., Lau, D., & Sanders, P. (2017). Simulated obstructive respiratory events, but not intermittent hypoxia alone, result in the development of an atrial arrhythmogenic substrate in a novel rat model for sleep apnea. In EUROPEAN HEART JOURNAL Vol. 38 (pp. 64-65). Barcelona, SPAIN: OXFORD UNIV PRESS.

  • Conference Items
    Year Citation
    2017 Hohl, M. M., Linz, B., Khoskhish, S., Nickel, A., Maack, C., Boehm, M., & Linz, D. (2017). Repetitive obstructive respiratory events favors the development of an atrial arrhythmogenic substrate in a novel rat model for sleep apnea. Poster session presented at the meeting of EUROPEAN JOURNAL OF HEART FAILURE. WILEY.
    2015 Ewen, S., Meyer, M., Cremers, B., Laufs, U., Linz, D., Kindermann, I., . . . Mahfoud, F. (2015). Blood pressure reductions following catheter-based renal denervation are not related to improvements in adherence to antihypertensive drugs measured by urine/ plasma toxicological analysis. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. London, ENGLAND: OXFORD UNIV PRESS.
    2014 Ewen, S., Ukena, C., Linz, D., Poess, J., Kindermann, I., Cremers, B., . . . Mahfoud, F. (2014). Percutaneous renal denervation effectively reduces blood pressure in patients with isolated systolic hypertension. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
    2014 Linz, D., Denner, A., Illing, S., Linz, B., Hohl, M., Ukena, C., . . . Boehm, M. (2014). Effects of acute and repetitive obstructive respiratory events on ventricular repolarization in a pig model for obstructive sleep apnea. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
    2014 Linz, D., Van Hunnik, A., Hohl, M., Mahfoud, F., Ukena, C., Verheule, S., . . . Schotten, U. (2014). Renal denervation reduces atrial fibrillation complexity in goats independently from changes in blood pressure. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
    2014 Linz, D., Schuetze, J., Linz, B., Hohl, M., Mahfoud, F., Ewen, S., & Boehm, M. (2014). Renal denervation attenuates progression of kidney and heart injury in obese spontaneously hypertensive rats. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Barcelona, SPAIN: OXFORD UNIV PRESS.
    WoS1
    2013 Ukena, C., Mahfoud, F., Dalinghoff, M., Adam, O., Linz, D., Schmidt, J., . . . Boehm, M. (2013). Comparison of unilateral versus bilateral renal denervation in patients with resistant hypertension. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
    WoS1
    2013 Hohl, M., Linz, D., Nickel, A., Schotten, U., Mahfoud, F., Maack, C., . . . Boehm, M. (2013). Renal sympathetic denervation suppresses atrial fibrillation in a pig model for sleep apnea. Poster session presented at the meeting of EUROPEAN JOURNAL OF HEART FAILURE. WILEY-BLACKWELL.
    2013 Linz, D., Hohl, M., Mahfoud, F., Schuetze, J., Ewen, S., Urban, D., . . . Boehm, M. (2013). Renal denervation reduces blood pressure and attenuates impairment of left ventricular compliance in obese spontaneously hypertensive rats. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
    2013 Linz, D., Mahfoud, F., Loehn, M., Linz, W., Wirth, K., & Boehm, M. (2013). Renal sympathetic denervation inhibits postapneic blood pressure rises and renal hypoperfusion in a pig model for obstructive sleep apnea. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
    2013 Mahfoud, F., Ukena, C., Adam, O., Dalinghoff, M., Linz, D., Schmidt, J., . . . Boehm, M. (2013). Procedural parameters during renal denervation and change of blood pressure in patients with resistant hypertension. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
    2013 Schuetze, J., Linz, D., Hohl, M., Mahfoud, F., Ewen, S., Urban, D., . . . Boehm, M. (2013). Renal denervation attenuates impairment of renal function and kidney injury in obese spontaneously hypertensive rats. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Amsterdam, NETHERLANDS: OXFORD UNIV PRESS.
    2012 Linz, D., Ukena, C., Mafhoud, F., Schotten, U., Neuberger, H., & Boehm, M. (2012). Renal sympathetic denervation suppresses postapneic blood pressure rises and inducibility of atrial fibrillation in a model for sleep apnea. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Munchen, GERMANY: OXFORD UNIV PRESS.
    2012 Linz, D., Loehn, M., Mahfoud, F., Ukena, C., Linz, W., Wirth, K., & Boehm, M. (2012). Effect of renal sympathetic denervation on blood pressure and renal perfusion in a pig model for obstructive sleep apnea. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Munchen, GERMANY: OXFORD UNIV PRESS.
    2012 Linz, D., Eckstein, J., Maesen, B., Van Hunnick, A., Verheule, S., & Schotten, U. (2012). Zooming in on the focus: flecainide inhibits atrial fibrillation maintained by aconitine. Poster session presented at the meeting of EUROPEAN HEART JOURNAL. Munchen, GERMANY: OXFORD UNIV PRESS.

Prizes and awards: On the basis of his work in the field of atrial arrhythmias, Dr Linz has been awarded the following prestigious National and International prizes:

Young Investigator Award, German Society of Hypertension, 2011

Award for Innovation, prestige award of the Association of German Academic Medicine (Deutsche Hochschulmedizin e.V.), 2012

Research Award “Dr. Adalbert Buding”, prestige award of the German Society of Hypertension, 2013

Winning Moderated Poster Presentation, European Society of Cardiology, 2014

Hans Jürgen-Bretschreider Poster Award, prestige award of the German Society of Cardiology, 2014

Research Award „Circulation and Sleep“, prestige award of the German Society of Sleep Medicine, 2014

Four Travel awards and four poster awards by the German Society of Cardiology, 2009 – 2017

Research funding: Over the past 5 years Dr Linz has obtained over $400,000 research support from the Else Kröner Fresenius Foundation, German Society of Cardiology, University Homburg/Saar, German Heart Foundation, German Society of Hypertension, German Research Foundation.

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  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Co-Supervisor Computer-guided Ablation Techniques for Atrial Fibrillation Doctor of Philosophy Doctorate Full Time Mr Simanto Saha
    2018 Co-Supervisor Upstream therapy of obesity and atrial fibrialation Doctor of Philosophy Doctorate Full Time Dr Kadhim Imad Kadhim
    2018 Co-Supervisor Sleep Arousals Detection and Continuous Blood Pressure Estimation Doctor of Philosophy Doctorate Full Time Mr Sobhan Salari Shahrbabaki
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  • Board Memberships
    Date Role Board name Institution name Country
    2014 - ongoing Board Member Working Group Cellular Electrophysiology German Society of Cardiology —
    2013 - ongoing Board Member Working Group Sleep Disordered Breathing in Cardiology German Society of Cardiology Germany

  • Committee Memberships
    Date Role Committee Institution Country
    2016 - ongoing Member Program committee, German Hypertension Society, Annual Meeting — Germany
    2016 - ongoing Member Steering Committee, SYNCHRO Study. Steering Committee SYNCHRO Study. —

  • Memberships
    Date Role Membership Country
    2013 - ongoing — German Hypertension Society —
    2013 - ongoing — German Society of Sleep Medicine Germany
    2009 - ongoing — European Society of Cardiology —
    2009 - ongoing — German Society of Cardiology —

  • Editorial Boards
    Date Role Editorial Board Name Institution Country
    2013 - 2016 Associate Editor Clinical Research in Cardiology — —
  • Position: Lecturer
  • Phone: 70741785
  • Email: dominik.linz@adelaide.edu.au
  • Campus: North Terrace
  • Building: SAHMRI, floor 8
  • Org Unit: Adelaide Medical School
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