Dr Dharmesh Bhuva
Postdoctoral Research Fellow
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dharmesh Bhuva is an early career computational biology researcher (PhD in 2020) in the Davis laboratory at SAiGENCI. He has developed high quality bioinformatics software and methods that enable exploration of molecular phenotypes in cancer systems. He currently works on developing statistical and computational methods to analyse high throughput spatial transcriptomics datasets.
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Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Gujarati Can read, write, speak and understand spoken Hindi Can speak and understand spoken Swahili Can speak and understand spoken -
Education
Date Institution name Country Title The University of Melbourne Australia PhD -
Research Interests
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Journals
Year Citation 2023 White, C. L., Kinross, K. M., Moore, M. K., Rasouli, E., Strong, R., Jones, J. M., . . . Hansford, J. R. (2023). Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study. Journal of Molecular Diagnostics, 25(10), 709-728.
2023 Liu, N., Bhuva, D. D., Mohamed, A., Bokelund, M., Kulasinghe, A., Tan, C. W., & Davis, M. J. (2023). standR: a Bioconductor package for analysing transcriptomic Nanostring GeoMx DSP data.
2023 Sharma, S., Chung, C. Y., Uryu, S., Petrovic, J., Cao, J., Rickard, A., . . . Paul, T. A. (2023). Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer. Cell Chemical Biology, 30(10), 1191-1210.e20.
Scopus12023 Hediyeh-zadeh, S., Whitfield, H. J., Kharbanda, M., Curion, F., Bhuva, D. D., Theis, F. J., & Davis, M. J. (2023). Identification of cell types, states and programs by learning gene set representations.
2023 Liu, N., Bhuva, D. D., Mohamed, A., Bokelund, M., Kulasinghe, A., Tan, C. W., & Davis, M. J. (2023). standR: spatial transcriptomic analysis for GeoMx DSP data. NUCLEIC ACIDS RESEARCH, 11 pages.
2023 Kulasinghe, A., Liu, N., Tan, C. W., Monkman, J., Sinclair, J. E., Bhuva, D. D., . . . Fraser, J. F. (2023). Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage. Immunology, 168(3), 403-419.
Scopus7 WoS6 Europe PMC62023 Bhuva, D., Tan, C. W., Marceaux, C., Chen, J., Kharbanda, M., Jin, X., . . . Davis, M. (2023). Library size confounds biology in spatial transcriptomics data.
2023 Vo, T., Balderson, B., Jones, K., Ni, G., Crawford, J., Millar, A., . . . Genovesi, L. A. (2023). Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition. Genome Medicine, 15(1), 29-1-29-28.
Europe PMC22023 Mohamed, A., Bhuva, D. D., Lee, S., Liu, N., Tan, C. W., & Davis, M. J. (2023). VissE.cloud: A webserver to visualise higher order molecular phenotypes from enrichment analysis. Nucleic Acids Research, 51(W1), W593-W600.
2022 Kulasinghe, A., Tan, C. W., Ribeiro Dos Santos Miggiolaro, A. F., Monkman, J., SadeghiRad, H., Bhuva, D. D., . . . O'Byrne, K. (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59(6), 1-19.
Scopus18 WoS18 Europe PMC172022 Berthelet, J., Foroutan, M., Bhuva, D. D., Whitfield, H. J., El-Saafin, F., Cursons, J., . . . Merino, D. (2022). Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin. Cancers, 14(10), 1-18.
Scopus1 WoS1 Europe PMC12022 San Juan, B., Hediyeh-Zadeh, S., Rangel, L., Milioli, H., Rodriguez, V., Bunkum, A., . . . Chaffer, C. (2022). Targeting phenotypic plasticity prevents metastasis and the development of chemotherapy-resistant disease.
2022 Kulasinghe, A., Liu, N., Tan, C. W., Monkman, J., Sinclair, J., Bhuva, D., . . . Fraser, J. (2022). Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage.
2022 Bhuva, D., Tan, C. W., Liu, N., Whitfield, H., Papachristos, N., Lee, S., . . . Davis, M. (2022). vissE: A versatile tool to identify and visualise higher-order molecular phenotypes from functional enrichment analysis.
2021 Genovesi, L. A., Millar, A., Tolson, E., Singleton, M., Hassall, E., Kojic, M., . . . Wainwright, B. J. (2021). Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome medicine, 13(1), 103-1-103-15.
Scopus7 WoS6 Europe PMC62020 Bhuva, D., Cursons, J., & Davis, M. (2020). Stable gene expression for normalisation and single-sample scoring.
2020 Bhuva, D. D., Cursons, J., & Davis, M. J. (2020). Stable gene expression for normalisation and single-sample scoring. Nucleic Acids Research, 48(19), E113-1-E113-14.
Scopus18 WoS7 Europe PMC182020 Kulasinghe, A., Tan, C. W., dos Santos Miggiolaro, A. F. R., Monkman, J., Bhuva, D., Motta Junior, J. D. S., . . . O’Byrne, K. (2020). Spatial Profiling of Lung SARS-CoV-2 and Influenza Virus Infection Dissects Virus-Specific Host Responses and Gene Signatures.
2019 Bhuva, D. D., Cursons, J., Smyth, G. K., & Davis, M. J. (2019). Differential co-expression-based detection of conditional relationships in transcriptional data: comparative analysis and application to breast cancer. Genome Biology, 20(1), 236-1-236-21.
Scopus32 WoS28 Europe PMC262019 Bhuva, D. D., Foroutan, M., Xie, Y., Lyu, R., Cursons, J., & Davis, M. J. (2019). Using singscore to predict mutation status in acute myeloid leukemia from transcriptomic signatures.. F1000Research, 8, 776.
Scopus9 Europe PMC72018 Foroutan, M., Bhuva, D. D., Lyu, R., Horan, K., Cursons, J., & Davis, M. J. (2018). Single sample scoring of molecular phenotypes. BMC Bioinformatics, 19(1), 404-1-404-10.
Scopus177 WoS168 Europe PMC147 -
Conference Papers
Year Citation 2022 Kulasinghe, A., Tan, C. W., Liu, N., Monkman, J., Killingbeck, E., Kim, Y., . . . Davis, M. (2022). DEEP SINGLE-CELL, PROTEOGENOMIC INSIGHTS FROM SARS-COV-2 INFECTED LUNG TISSUES. In JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 10 (pp. A962). BMJ PUBLISHING GROUP.
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Conference Items
Year Citation 2022 Tuan, V., Balderson, B., Jones, K., Crawford, J., Millar, A., Tolson, E., . . . Genovesi, L. (2022). SPATIAL TRANSCRIPTOMIC ANALYSIS OF SONIC HEDGEHOG MEDULLOBLASTOMA IDENTIFIES THAT LOSS OF HETEROGENEITY AND INDUCED DIFFERENTIATION UNDERLIES THE RESPONSE TO CDK4/6 INHIBITION. Poster session presented at the meeting of NEURO-ONCOLOGY. Hamburg, GERMANY: OXFORD UNIV PRESS INC.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Molecular Phenotypes in Space: Identifying Spatial Biomarkers Using Computational Histopathology Doctor of Philosophy Doctorate Full Time Ms Malvika Kharbanda
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Memberships
Date Role Membership Country 2017 - ongoing Member Australian Bioinformatics and Computational Biology Society Australia
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