Dr Dhani Dharmaprani
Future Making Fellow
Australian Institute for Machine Learning - Operations
Division of Research and Innovation
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr. Dhani Dharmaprani is a Biomedical Engineer and Future Making Fellow at the Australian Institute for Machine Learning (AIML), University of Adelaide. As a biomedical engineer, her overarching research vision is to transform cardiovascular health through pioneering digital technologies and innovative analytical approaches. A focal point of this ambition has been cardiac fibrillation, the predominant cause of cardiac hospitalisations which imposes a $1.25billion/annum burden on Australia. To help address this, her current research explores computational, analytical, and machine learning approaches to better understand the mechanisms underlying this cardiac abnormality.
Her specific research projects in this domain include signal processing, patient-specific 'virtual hearts' or cardiac digital twins – personalised digital representations of the heart, and metrics to gauge cardiac behaviour and treatment efficacy – currently being used clinically by cardiologists at Flinders Medical Centre.
Dhani is also currently affiliated with the Cardiac Signals Analysis Lab led by Professor Anand Ganesan at Flinders University, and has also recently had the great pleasure of visiting the Personalised Computational Modelling (PCM) lab at Queen Mary University London under the mentorship Dr Caroline Roney, and Professor Steven Niederer at the Cardiac Electromechanics Group (CEMRG) at Imperial College London.
Research areas:
- Machine learning
- Medical AI
- Computational modelling
- Signal processing
- Cardiac electrophysiology and cardiology
Available research projects:
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Developing Patient-Specific Cardiac Digital Twins Using Clinical Data: This project focuses on creating highly personalised digital models of patients' hearts using clinical data.
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Applying Machine Learning to Develop Precision Medicine Tools: These projects aim to leverage machine learning techniques to develop patient-specific computational methods and tools to improve patient diagnosis, management, and treatment.
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Translating Clinical Metrics to Computational Models: This project involves integrating clinical metrics into computational models of cardiac arrhythmias.
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Signal Processing of Cardiac Patient Data: This project involves analysing and interpreting cardiac signal data from patients, and developing metrics/algorithms to understand cardiac mechanisms.
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Appointments
Date Position Institution name 2024 - ongoing Future Making Fellow University of Adelaide 2023 - 2023 Visiting Scholar Queen Mary University of London and Imperial College London 2020 - 2023 Postdoctoral Research Fellow Flinders University -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Indonesian Can read, write, speak and understand spoken -
Education
Date Institution name Country Title Flinders University Australia PhD Flinders University Australia Bachelor of Engineering (Biomedical) (Honours)
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Journals
Year Citation 2024 Chapman, D., Strong, C., Tiver, K. D., Dharmaprani, D., Jenkins, E., & Ganesan, A. N. (2024). Infra-Red Imaging to Detect Respirator Leak in Healthcare Workers During Fit-Testing Clinic. IEEE Open Journal of Engineering in Medicine and Biology, 5, 198-204.
2023 Jenkins, E. V., Dharmaprani, D., Schopp, M., Quah, J. X., Tiver, K., Mitchell, L., . . . Ganesan, A. N. (2023). Markov modeling of phase singularity interaction effects in human atrial and ventricular fibrillation.. Chaos, 33(6), 10 pages.
2023 Roney, C. H., Solis Lemus, J. A., Lopez Barrera, C., Zolotarev, A., Ulgen, O., Kerfoot, E., . . . Niederer, S. (2023). Constructing bilayer and volumetric atrial models at scale. Interface Focus, 13(6), 13 pages.
Scopus1 WoS12022 Jenkins, E. V., Dharmaprani, D., Schopp, M., Quah, J. X., Tiver, K., Mitchell, L., . . . Ganesan, A. N. (2022). Understanding the origins of the basic equations of statistical fibrillatory dynamics. Chaos: An Interdisciplinary Journal of Nonlinear Science, 32(3), 032101-1-032101-12.
Scopus3 WoS3 Europe PMC22022 Jenkins, E. V., Dharmaprani, D., Schopp, M., Quah, J. X., Tiver, K., Mitchell, L., . . . Ganesan, A. N. (2022). The inspection paradox: An important consideration in the evaluation of rotor lifetimes in cardiac fibrillation.. Front Physiol, 13, 920788.
Scopus2 WoS12022 Quah, J. X., Jenkins, E., Dharmaprani, D., Tiver, K., Smith, C., Hecker, T., . . . Ganesan, A. (2022). Role of interatrial conduction in atrial fibrillation: Mechanistic insights from renewal theory–based fibrillatory dynamic analysis. Heart Rhythm O2, 3(4), 335-343.
Scopus2 WoS1 Europe PMC22022 Tiver, K. D., Dharmaprani, D., Quah, J. X., Lahiri, A., Waddell-Smith, K. E., & Ganesan, A. N. (2022). Vomiting, electrolyte disturbance, and medications; the perfect storm for acquired long QT syndrome and cardiac arrest: a case report. Journal of Medical Case Reports, 16(1), 5 pages.
Scopus6 WoS6 Europe PMC42021 Quah, J. X., Dharmaprani, D., Lahiri, A., Tiver, K., & Ganesan, A. N. (2021). Reconceptualising atrial fibrillation using renewal theory: A novel approach to the assessment of atrial fibrillation dynamics. Arrhythmia and Electrophysiology Review, 10(2), 77-84.
Scopus4 WoS3 Europe PMC32021 Schopp, M., Dharmaprani, D., Kuklik, P., Quah, J., Lahiri, A., Tiver, K., . . . Ganesan, A. N. (2021). Spatial concentration and distribution of phase singularities in human atrial fibrillation: Insights for the AF mechanism. Journal of Arrhythmia, 37(4), 922-930.
Scopus3 WoS3 Europe PMC22021 Tiver, K. D., Quah, J., Dharmaprani, D., & Ganesan, A. N. (2021). Reality is Far From the Guidelines, When it Comes to Stroke Prevention in Atrial Fibrillation. Heart Lung and Circulation, 30(7), 935-936.
2021 Quah, J. X., Dharmaprani, D., Tiver, K., Lahiri, A., Hecker, T., Perry, R., . . . Ganesan, A. (2021). Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards. Journal of Cardiovascular Electrophysiology, 32(4), 1147-1160.
Scopus15 WoS11 Europe PMC92021 Dharmaprani, D., Jenkins, E. V., Quah, J. X., Lahiri, A., Tiver, K., Mitchell, L., . . . Ganesan, A. N. (2021). A governing equation for rotor and wavelet number in human clinical ventricular fibrillation: implications for sudden cardiac death. Heart Rhythm, 19(2), 295-305.
Scopus10 WoS8 Europe PMC82020 Dharmaprani, D., Lahiri, A., Ganesan, A. N., Kyriacou, N., & McGavigan, A. D. (2020). Comparative spatial resolution of 12-lead electrocardiography and an automated algorithm. Heart Rhythm, 17(2), 324-331.
Scopus5 WoS3 Europe PMC22020 Quah, J., Dharmaprani, D., Lahiri, A., Schopp, M., Mitchell, L., Selvanayagam, J. B., . . . Ganesan, A. N. (2020). Prospective cross-sectional study using Poisson renewal theory to study phase singularity formation and destruction rates in atrial fibrillation (RENEWAL-AF): Study design. Journal of Arrhythmia, 36(4), 660-667.
Scopus4 WoS4 Europe PMC42020 Dharmaprani, D., Jenkins, E., Aguilar, M., Quah, J. X., Lahiri, A., Tiver, K., . . . Ganesan, A. N. (2020). M/M/infinity birth-death processes - a quantitative representational framework to summarize and explain phase singularity and wavelet dynamics in atrial fibrillation. Frontiers in Physiology, 11, 616866-1-616866-17.
Scopus13 WoS13 Europe PMC92019 Dharmaprani, D., McGavigan, A. D., Chapman, D., Kutlieh, R., Thanigaimani, S., Dykes, L., . . . Ganesan, A. N. (2019). Temporal stability and specificity of high bipolar electrogram entropy regions in sustained atrial fibrillation: implications for mapping. Journal of Electrocardiology, 53, 18-27.
Scopus6 WoS5 Europe PMC42019 Dharmaprani, D., Schopp, M., Kuklik, P., Chapman, D., Lahiri, A., Dykes, L., . . . Ganesan, A. N. (2019). Renewal theory as a universal quantitative framework to characterize phase singularity regeneration in mammalian cardiac fibrillation. Circulation: Arrhythmia and Electrophysiology, 12(12), e007569.
Scopus29 WoS26 Europe PMC232019 Ganesan, A. N., Dharmaprani, D., & McGavigan, A. D. (2019). Letter by Ganesan et al Regarding Article, "wavefront Field Mapping Reveals a Physiologic Network between Drivers Where Ablation Terminates Atrial Fibrillation". Circulation: Arrhythmia and Electrophysiology, 12(11), 2 pages.
Scopus1 WoS12018 Dharmaprani, D., Dykes, L., McGavigan, A. D., Kuklik, P., Pope, K., & Ganesan, A. N. (2018). Information theory and Atrial Fibrillation (AF): A review. Frontiers in Physiology, 9(JUL), 19 pages.
Scopus24 WoS22 Europe PMC13 -
Conference Papers
Year Citation 2023 Dharmaprani, D., Jenkins, E. V., Tiver, K., Shahrbabaki, S. S., Strong, C., Chapman, D., & Ganesan, A. N. (2023). Percolation theory as a conceptual framework to explain spontaneous atrial fibrillation termination: a pilot study. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS Vol. 2023 (pp. 4 pages). AUSTRALIA, Sydney: IEEE.
2016 Dharmaprani, D., Nguyen, H. K., Lewis, T. W., Delosangeles, D., Willoughby, J. O., & Pope, K. J. (2016). A comparison of independent component analysis algorithms and measures to discriminate between EEG and artifact components. In J. Patton, R. Barbieri, J. Ji, E. Jabbari, S. Dokos, R. Mukkamala, . . . A. P. Dhawan (Eds.), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS Vol. 2016-October (pp. 825-828). FL, Orlando: IEEE.
Scopus6 WoS6 Europe PMC3
GRANTS AND FUNDING
2024 Future Making Fellowship, University of Adelaide
This fellowship is being undertaken at the Australian Institute for Machine Learning, and will focus on research to develop computational and precision medicine tools for cardiology using modelling, machine learning and signal processing.
2022 The Hospital Research Foundation Heart Health Innovation Grant ($125,000).
This grant is being used to help develop Australia’s first advanced 3D models of cardiac fibrillation in collaboration with King’s College London and Queen Mary University of London. Simultaneously, I will transfer critical computational cardiac modelling skills/ expertise within Australia. (CIA Dharmaprani).
2021 Medical Research Future Fund Cardiovascular Health Mission Grant ($604,000).
This grant is being used to develop novel real-time software to translate my research into the clinical setting and allow use in patients. (CIA, Ganesan, CIB Dharmaprani).
2021 National Health and Medical Research Council Ideas Grant ($1,160,000).
This grant is being used to fund human clinical trials and explore cardiac fibrillation through a multi-center study, which is based on my PhD research findings. (CIA, Ganesan, CID Dharmaprani).
2020 Tom Simpson Trust Equipment Grant, administered through the National Heart Foundation of Australia ($15,000).
To fund the purchase and development of Australia’s first optical mapping system (CIA Dharmaprani).
2019 Heart Rhythm Society Travel Scholarship ($1,000USD).
2019 Hospital Research Foundation Travel Scholarship ($3,500).
2019 Flinders University RHD Travel Grant ($500).
AWARDS AND HONOURS
1. Finalist 7News Young Achiever Award (STEM), 2024
2. Finalist SA Woman of the Year (Innovator), 2024
3. Flinders University Early Career Alumni Award, 2023
4. Science and Technology's Superstars of STEM, 2023-2024
5. Finalist 7News Young Achiever Award (STEM), 2023
6. Flinders University Vice Chancellor's Award for Early Career Researchers, 2022
7. Women In Innovation Winnovation Awards Finalist for categories of: i) Engineering, ii) Maths & Data, iii) Technology, and winner for Maths & Data, 2022
8. Fresh Science's South Australian Fresh Scientist, 2021
9. Flinders University Dean (Education) Award for Excellence in Teaching Special Mention, 2021
10. Heart Rhythm Society (HRS) Young Investigator Award Finalist, 2021
11. Cardiac Electrophysiology Society (CEPS) Young Investigator Award Finalist, 2021
12. Flinders University College of Medicine and Public Health Publication Award, 2019
13. Cardiac Electrophysiology Society (CEPS) Young Investigator Award Finalist, 2019
14. Asia Pacific Heart Rhythm Society (APHRS) Young Investigator of the Year Finalist, 2019
15. Flinders University 3-Minute Thesis Competition Finalist, 2019
16. 3x Travel Grants
17. Cardiac Society of Australia and New Zealand (CSANZ) Heart Rhythm Prize winner, 2018
18. Asia Pacific Heart Rhythm Society (APHRS) Young Investigator of the Year, 2018
19. Most Outstanding Biomedical Engineering Honours or Masters project, 2016
MEDIA
1. Featured in News Corp's '25 Influential Australian Female Scientists' national article, 2023
2. Featured in The Advertiser's '21 South Aussies to Watch in 2023' article, 2023
3. Featured in RAA SAMove's 'South Australians Driving Change' article, 2023
Previous Teaching
- Analysis of Engineering Systems/Signals and Systems
- Biomedical Instrumentation
- Biomaterials
- Medical Device Innovation
- Professional Skills
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Quantifying the onset of atrial fibrillation as a phase transition from synchrony into chaos Doctor of Philosophy Doctorate Full Time Mr Luke Phillip O'Loughlin
Connect With Me
External Profiles
