Dawn Thean

Research Interests

Cancer Cell Biology Cancer Therapy Genetics

Miss Dawn Thean

Higher Degree by Research Candidate

School of Pharmacy and Biomedical Sciences

College of Health

Currently conducting my post graduate studies at the Gene Regulation in Cancer Laboratory, my focus is to undertand the functional roles of alternative splicing that regulates cellular plasticity in triple negative breast cancer. 

Date Position Institution name
2022 - 2025 Research Officer University of Adelaide
2018 - 2022 Research Assistant Hong Kong University of Science and Technology
2014 - 2018 Research Officer Agency for Science, Technology and Research

Language Competency
English Can read, write, speak and understand spoken

Date Institution name Country Title
2012 - 2013 University of Adelaide Australia Honours Degree of Bachelor of Science
2009 - 2012 University of Adelaide Australia Bachelor of Science (Biomedical Science)

Date Title Institution Country
2026 PhD University of Adelaide Australia

Year Citation
2024 Chu, H. Y., Fong, J. H. C., Thean, D. G. L., Zhou, P., Fung, F. K. C., Huang, Y., & Wong, A. S. L. (2024). Accurate top protein variant discovery via low-N pick-and-validate machine learning. CELL SYSTEMS, 15(2), 18 pages.
DOI WoS2 Europe PMC2
2022 Thean, D. G. L., Chu, H. Y., Fong, J. H. C., Chan, B. K. C., Zhou, P., Kwok, C. C. S., . . . Wong, A. S. L. (2022). Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities. NATURE COMMUNICATIONS, 13(1), 14 pages.
DOI WoS32 Europe PMC28
2022 Yuen, C. T. L., Thean, D. G. L., Chan, B. K. C., Zhou, P., Kwok, C. C. S., Chu, H. Y., . . . Wong, A. S. L. (2022). High-fidelity KKH variant of <i>Staphylococcus aureus</i> Cas9 nucleases with improved base mismatch discrimination. NUCLEIC ACIDS RESEARCH, 50(3), 1650-1660.
DOI WoS18 Europe PMC21
2022 Frosi, Y., Lin, Y. -C., Jiang, S., Ramlan, S. R., Hew, K., Engman, A. H., . . . Brown, C. J. (2022). Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. NATURE COMMUNICATIONS, 13(1), 22 pages.
DOI WoS5
2021 Desai, T. J., Habulihaz, B., Cannon, J. R., Chandramohan, A., Kaan, H. Y. K., Sadruddin, A., . . . Hochman, J. (2021). Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides (Mar, 10.1007/s11095-021-03005-z, 2021). PHARMACEUTICAL RESEARCH, 38(4), 735-736.
DOI
2021 Desai, T. J., Habulihaz, B., Cannon, J. R., Chandramohan, A., Kaan, H. Y. K., Sadruddin, A., . . . Hochman, J. (2021). Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides. PHARMACEUTICAL RESEARCH, 38(5), 843-850.
DOI WoS13 Europe PMC10
2021 Thean, D. G. L., & Wong, A. S. L. (2021). Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation. NEURAL REGENERATION RESEARCH, 16(12), 2403-2404.
DOI
2021 Peier, A., Ge, L., Boyer, N., Frost, J., Duggal, R., Biswas, K., . . . Partridge, A. W. (2021). NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay. ACS CHEMICAL BIOLOGY, 16(2), 293-309.
DOI WoS35 Europe PMC38
2020 Kannan, S., Aronica, P. G. A., Ng, S., Gek Lian, D. T., Frosi, Y., Chee, S., . . . Partridge, A. W. (2020). Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.. Chemical science, 11(21), 5577-5591.
DOI Europe PMC28
2019 Yuen, T. Y., Brown, C. J., Xue, Y., Tan, Y. S., Gago, F. J. F., Lee, X. E., . . . Johannes, C. W. (2019). Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles. CHEMICAL SCIENCE, 10(26), 6457-6466.
DOI WoS24 Europe PMC20
2019 Frosi, Y., Usher, R., Lian, D. T. G., Lane, D. P., & Brown, C. J. (2019). Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly.. BMC biology, 17(1), 40.
DOI Europe PMC10
2019 Diller, D. J., Swanson, J., Bayden, A. S., Brown, C. J., Thean, D., Lane, D. P., . . . Audie, J. (2019). Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides. MOLECULES, 24(24), 28 pages.
DOI WoS4 Europe PMC2
2019 Choi, G. C. G., Zhou, P., Yuen, C. T. L., Chan, B. K. C., Xu, F., Bao, S., . . . Wong, A. S. L. (2019). Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9. NATURE METHODS, 16(8), 722-+.
DOI WoS47 Europe PMC52
2019 Partridge, A. W., Kaan, H. Y. K., Juang, Y. -C., Sadruddin, A., Lim, S., Brown, C. J., . . . Sawyer, T. K. (2019). Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties. MOLECULES, 24(12), 21 pages.
DOI WoS38 Europe PMC33
2019 Choi, G. C. G., Zhou, P., Yuen, C. T. L., Chan, B. K. C., Xu, F., Bao, S., . . . Wong, A. S. L. (2019). Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 (vol 16, pg 722, 2019). NATURE METHODS, 16(8), 789.
DOI
2017 Chee, S. M. Q., Wongsantichon, J., Siau, J., Thean, D., Ferrer, F., Robinson, R. C., . . . Ghadessy, F. J. (2017). Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids. PLOS ONE, 12(12), 15 pages.
DOI WoS9 Europe PMC9
2017 Thean, D., Ebo, J. S., Luxton, T., Lee, X. C., Yuen, T. Y., Ferrer, F. J., . . . Brown, C. J. (2017). Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery. SCIENTIFIC REPORTS, 7(1), 11 pages.
DOI WoS29 Europe PMC26
2016 Tan, Y. S., Reeks, J., Brown, C. J., Thean, D., Gago, F. J. F., Yuen, T. Y., . . . Verma, C. S. (2016). Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 7(17), 3452-3457.
DOI WoS36 Europe PMC38

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