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Professor David Saint

David Saint
Professor
Adelaide Medical School
Faculty of Health and Medical Sciences

Current projects in the laboratory
• The mechanisms underlying mechanoelectric feedback and arrhythmias in cardiac tissue
• Cardioprotection using novel therapeutic targets
• The mechanisms underlying atrial fibrillation
• The use of heart rate variability (HRV) as a diagnostic marker, and mechanisms of HRV

Professor David Saint

Current projects in the laboratory
• The mechanisms underlying mechanoelectric feedback and arrhythmias in cardiac tissue
• Cardioprotection using novel therapeutic targets
• The mechanisms underlying atrial fibrillation
• The use of heart rate variability (HRV) as a diagnostic marker, and mechanisms of HRV

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

Appointments

Date Position Institution name
2005 Associate Professor University of Adelaide
2004 - 2006 CEO Verona Pharma Ltd
1999 - 2004 Senior Lecturer University of Adelaide
1996 - 1999 NH&MRC Senior Research Officer University of Adelaide
1996 - 1999 Visiting Fellow Australian National University
1995 - 1996 Senior Toxicologist Australian Government
1992 - 1995 NH&MRC Senior Research Officer University of Canberra
1992 - 1995 Visiting Fellow Australian National University
1987 - 1992 Research Fellow Australian National University
1982 - 1987 Post-Doctoral Fellow/Research Associate University of British Columbia

Awards and Achievements

Date Type Title Institution Name Country Amount
2012 Award The Michael Roberts Excellence in Physiology Education Award Australian Physiological Society Australia
2012 Award The Executive Dean’s Prize for Excellence in Teaching University of Adelaide Australia

Education

Date Institution name Country Title
2003 University of Adelaide Australia MBA (Advanced)
1978 - 1982 University of St. Andrews Scotland PhD
1973 - 1978 University of Leeds United Kingdom BSc (Hons)

Certifications

Date Title Institution name Country
2012 GAICD Australian Institute of Company Directors Australia

Research Interests

Journals

Year Citation
2017 Horton, D., Saint, D., Owens, J., Gatford, K., & Kind, K. (2017). Use of the hyperinsulinemic euglycemic clamp to assess insulin sensitivity in guinea pigs: Dose response, partitioned glucose metabolism, and species comparisons. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 313(1), 19-28.
DOI
2016 Lim, W., Baumert, M., Neo, M., Kuklik, P., Ganesan, A., Lau, D., . . . Saint, D. (2016). Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 43(1), 95-101.
DOI Scopus1 WoS1 Europe PMC1
2016 Neo, M., Morris, D., Kuklik, P., Lau, D., Dimitri, H., Lim, W., . . . Saint, D. (2016). Simultaneous conduction mapping and intracellular membrane potential recording in isolated atria. Canadian Journal of Physiology and Pharmacology, 94(5), 563-569.
DOI
2016 Lee, S., Hutchinson, M., & Saint, D. (2016). The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology and Physiology, 43(9), 864-871.
DOI Scopus4 WoS4 Europe PMC4
2016 Horton, D., Saint, D., Owens, J., Kind, K., & Gatford, K. (2016). Spontaneous intrauterine growth restriction due to increased litter size in the Guinea pig programmes postnatal growth, appetite and adult body composition. Journal of Developmental Origins of Health and Disease, 7(5), 548-562.
DOI Scopus3 WoS3 Europe PMC2
2015 Lee, S., Hutchinson, M., Staikopoulos, V., & Saint, D. (2015). Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. International Journal of Cardiology, 190, 353-359.
DOI Scopus5 WoS5 Europe PMC4
2015 Pugsley, M., Saint, D., Hayes, E., Abraham, S., & Walker, M. (2015). An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist. European Journal of Pharmacology, 761, 330-340.
DOI Scopus1 WoS1 Europe PMC1
2015 Saint, D., Horton, D., Yool, A., & Elliott, A. (2015). A progressive assessment strategy improves student learning and perceived course quality in undergraduate physiology. Advances in Physiology Education, 39(3), 218-222.
DOI Scopus1 WoS1
2015 Immanuel, S., Kohler, M., Martin, A., Kennedy, J., Pamula, Y., Kabir, M., . . . Baumert, M. (2015). Increased thoracoabdominal asynchrony during breathing periods free of discretely scored obstructive events in children with upper airway obstruction. Sleep and Breathing, 19(1), 65-71.
DOI Scopus2 WoS3
2014 Immanuel, S., Pamula, Y., Kohler, M., Martin, J., Kennedy, D., Saint, D., & Baumert, M. (2014). Respiratory cycle-related electroencephalographic changes during sleep in healthy children and in children with sleep disordered breathing. Sleep, 37(8), 1353-1361.
DOI Scopus5 WoS4 Europe PMC2
2014 Coussens, S., Baumert, M., Kohler, M., Martin, J., Kennedy, D., Lushington, K., . . . Pamula, Y. (2014). Movement distribution: a new measure of sleep fragmentation in children with upper airway obstruction. Sleep, 37(12), 2025-2034.
DOI Scopus4 WoS4 Europe PMC3
2014 Immanuel, S., Pamula, Y., Kohler, M., Martin, J., Kennedy, D., Nalivaiko, E., . . . Baumert, M. (2014). Heartbeat evoked potentials during sleep and daytime behavior in children with sleep disordered breathing. American Journal of Respiratory and Critical Care Medicine, 190(10), 1149-1157.
DOI Scopus11 WoS9 Europe PMC8
2014 Benoist, D., Stones, R., Benson, A., Fowler, E., Drinkhill, M., Hardy, M., . . . White, E. (2014). Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline. Progress in Biophysics and Molecular Biology, 115(2-3), 162-172.
DOI Scopus10 WoS10 Europe PMC7
2014 Saint, D. (2014). Finding a niche in a changing sociological, technological and scientific world-AIMS Biophysics. AIMS Biophysics, 1(1), 49-50.
DOI
2014 Kelly, D., Mackenzie, L., & Saint, D. (2014). Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart. AIMS Biophysics, 1(1), 16-30.
DOI Scopus1
2013 Curtis, M., Hancox, J., Farkas, A., Wainwright, C., Stables, C., Saint, D., . . . Walker, M. (2013). The lambeth conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology & Therapeutics, 139(2), 213-248.
DOI Scopus110 WoS97 Europe PMC66
2013 Weiss, S., Dahlstrom, J., & Saint, D. (2013). Riluzole reduces arrhythmias and myocardial damage induced by coronary occlusion in anaesthetized pigs. Clinical and Experimental Pharmacology and Physiology, 40(12), 856-863.
DOI Scopus2 WoS2 Europe PMC2
2013 Lau, D., Shipp, N., Kelly, D., Thanigaimani, S., Neo, M., Kuklik, P., . . . Sanders, P. (2013). Atrial arrhythmia in ageing spontaneously hypertensive rats: Unraveling the substrate in hypertension and ageing. PLoS One, 8(8), 1-10.
DOI Scopus34 WoS31 Europe PMC21
2013 Alasady, M., Shipp, N., Brooks, A., Lim, H., Lau, D., Barlow, D., . . . Sanders, P. (2013). Myocardial infarction and atrial fibrillation importance of atrial ischemia. Circulation, Arrhythmia & Electrophysiology (Print), 6(4), 738-745.
DOI Scopus19 WoS18 Europe PMC10
2012 Kabir, M., Saint, D., Abbott, D., & Baumert, M. (2012). Effect of postural changes on cardiorespiratory coordination in humans. Computers & Electrical Engineering, 4(3), 274-277.
2012 Immanuel, S., Pamula, Y., Kohler, M., Martin, A., Kennedy, J., Kabir, M., . . . Baumert, M. (2012). Respiratory timing and variability during sleep in children with sleep-disordered breathing. Journal of Applied Physiology, 113(10), 1635-1642.
DOI Scopus13 WoS11 Europe PMC5
2012 Kim, D., White, E., & Saint, D. (2012). Increased mechanically-induced ectopy in the hypertrophied heart. Progress in Biophysics & Molecular Biology, 110(2-3), 331-339.
DOI Scopus9 WoS9 Europe PMC4
2012 Horton, D., Wiederman, S., & Saint, D. (2012). Assessment outcome is weakly correlated with lecture attendance: influence of learning style and use of alternative materials. Advances in Physiology Education, 36(2), 108-115.
DOI Scopus26 WoS20 Europe PMC18
2012 Benoist, D., Stones, R., Drinkhill, M., Benson, A., Yang, Z., Cassan, C., . . . White, E. (2012). Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. American Journal of Physiology-Heart and Circulatory Physiology, 302(11), H2381-H2395.
DOI Scopus38 WoS32 Europe PMC25
2012 Dimitri, H., Ng, M., Brooks, A., Kuklik, P., Stiles, M., Lau, D., . . . Sanders, P. (2012). Atrial remodeling in obstructive sleep apnea: implications for atrial fibrillation. Heart Rhythm, 9(3), 321-327.
DOI Scopus130 WoS113 Europe PMC83
2011 Kabir, M., Saint, D., Nalivaiko, E., Abbott, D., & Baumert, M. (2011). Time delay correction of the synchrogram for optimized detection of cardiorespiratory coordination. Medical & Biological Engineering & Computing, 49(11), 1249-1259.
DOI Scopus3 WoS2 Europe PMC1
2011 Kabir, M., Saint, D., Nalivaiko, E., Abbott, D., Voss, A., & Baumert, M. (2011). Quantification of cardiorespiratory interactions based on joint symbolic dynamics. Annals of Biomedical Engineering, 39(10), 2604-2614.
DOI Scopus30 WoS26 Europe PMC11
2011 Saint, D. (2011). Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing. Progress in Biophysics & Molecular Biology, 107(1), 4-10.
DOI Scopus29 WoS29 Europe PMC24
2011 Sjoberg, N., & Saint, D. (2011). A single 4 mg dose of nicotine decreases heart rate variability in healthy nonsmokers: Implications for smoking cessation programs. Nicotene & Tobacco Research, 13(5), 369-372.
DOI Scopus28 WoS24 Europe PMC17
2011 Lau, D., Psaltis, P., Mackenzie, L., Kelly, D., Carbone, A., Worthington, M., . . . Sanders, P. (2011). Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort. Journal of Cardiovascular Electrophysiology, 22(2), 175-182.
DOI Scopus27 WoS24 Europe PMC12
2011 Lau, D., Psaltis, P., Carbone, A., Kelly, D., Mackenzie, L., Worthington, M., . . . Sanders, P. (2011). Atrial protective effects of n-3 polyunsaturated fatty acids: A long-term study in ovine chronic heart failure. Heart Rhythm, 8(4), 575-582.
DOI Scopus24 WoS20 Europe PMC13
2011 Sjoberg, N., Brinkworth, G., Wycherley, T., Noakes, M., & Saint, D. (2011). Moderate weight loss improves heart rate variability in overweight and obese adults with type 2 diabetes. Journal of Applied Physiology, 110(4), 1060-1064.
DOI Scopus20 WoS20 Europe PMC15
2011 Beig, M., Callister, R., Saint, D., Bondarenko, E., Walker, F., Day, T., & Nalivaiko, E. (2011). Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac arrhythmias in rats. Clinical and Experimental Pharmacology and Physiology, 38(1), 19-26.
DOI Scopus4 WoS4 Europe PMC3
2010 Weiss, S., & Saint, D. (2010). The persistent sodium current blocker Riluzole Is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction. PLoS One, 5(11), 1-13.
DOI Scopus7 WoS4 Europe PMC5
2010 Lau, D., Mackenzie, L., Shipp, N., Kuklik, P., Dimitri, H., Lobb, B., . . . Sanders, P. (2010). Feasibility of high-density electrophysiological study using multiple-electrode array in isolated small animal atria. Clinical and Experimental Pharmacology and Physiology, 37(10), 1023-1027.
DOI Scopus5 WoS4 Europe PMC3
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Brooks, A., Worthington, M., . . . Sanders, P. (2010). Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model. Heart Rhythm, 7(9), 1282-1290.
DOI Scopus95 WoS83 Europe PMC55
2010 Weiss, S., Benoist, D., White, E., Teng, W., & Saint, D. (2010). Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current. British Journal of Pharmacology, 160(5), 1072-1082.
DOI Scopus17 WoS15 Europe PMC13
2010 Lau, D., Mackenzie, L., Rajendram, A., Psaltis, P., Kelly, D., Spyropoulos, P., . . . Sanders, P. (2010). Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model. Blood Pressure, 19(2), 119-125.
DOI Scopus8 WoS7 Europe PMC8
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Worthington, M., Rajendram, A., . . . Sanders, P. (2010). Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model. Heart Rhythm, 7(3), 396-404.
DOI Scopus53 WoS51 Europe PMC39
2010 Sjoberg, N., Milte, C., Buckley, J., Howe, P., Coates, A., & Saint, D. (2010). Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation. British Journal of Nutrition, 103(2), 243-248.
DOI Scopus25 WoS26 Europe PMC23
2009 Wilson, D., Smith, C., Turner, S., Saint, D., & Beltrame, J. (2009). Response to Is Combined L- and T-Channel Blockade Better than L-Channel Blockade in Therapy?. Hypertension, 54(1), E4.
DOI
2009 Smith, C., Wilson, D., Turner, S., Saint, D., & Beltrame, J. (2009). Heterogeneity of L- and T-channels in the vasculature: Rationale for the efficacy of combined L- and T-blockade. Hypertension, 53(4), 654-660.
DOI Scopus36 WoS33 Europe PMC27
2009 Saint, D. (2009). Persistent (current) in the face of adversity ... A new class of cardiac anti-ischaemic compounds on the horizon?. British Journal of Pharmacology, 156(2), 211-213.
DOI Scopus3 WoS1 Europe PMC1
2008 Murphy, K., Saint, D., & Howe, P. (2008). Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits. Journal of the American College of Nutrition, 27(4), 476-484.
DOI Scopus5 WoS5 Europe PMC2
2008 Ninio, D., Hill, A., Howe, P., Buckley, J., & Saint, D. (2008). Docosahexaenoic acid-rich fish oil improves heart rate variability and heart rate responses to exercise in overweight adults. British Journal of Nutrition, 100(5), 1097-1103.
DOI Scopus31 WoS31 Europe PMC23
2008 Ninio, D., & Saint, D. (2008). The role of stretch-activated channels in atrial fibrillation and the impact of intracellular acidosis. Progress in Biophysics & Molecular Biology, 97(2-3), 401-416.
DOI Scopus25 WoS20 Europe PMC14
2008 Smith, C., Saint, D., Wilson, D., & Beltrame, J. (2008). Heterogeneity in vasomotor responses to L- and T-type calcium channel blockers. Journal of Molecular and Cellular Cardiology, 44(4), 817-818.
DOI
2008 Jones, I., Ricciardi, L., Hall, L., Hansen, H., Varadan, V., Bertram, C., . . . Abbott, D. (2008). Wireless RF communication in biomedical applications. Smart Materials & Structures, 17(1), WWW 1-WWW 10.
DOI Scopus16 WoS9
2008 Saint, D. (2008). The cardiac persistent sodium current: an appealing therapeutic target?. British Journal of Pharmacology, 153(6), 1133-1142.
DOI Scopus84 WoS74 Europe PMC59
2006 Saint, D. (2006). The role of the persistent Na+ current during cardiac ischemia and hypoxia. Journal of Cardiovascular Electrophysiology, 17(1), S96-S103.
DOI Scopus51 Europe PMC29
2006 Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D., & James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1761(12), 1443-1449.
DOI Scopus25 WoS23 Europe PMC15
2006 Ninio, D., & Saint, D. (2006). Passive pericardial constraint protects against stretch-induced vulnerability to atrial fibrillation in rabbits. American Journal of Physiology-Heart and Circulatory Physiology, 291(5), H2547-H2549.
DOI Scopus8 WoS9 Europe PMC8
2006 Kelly, D., Mackenzie, L., Hunter, P., Smaill, B., & Saint, D. (2006). Gene expression of stretch-activated channels and mechanoelectric feedback in the heart. Clinical and Experimental Pharmacology and Physiology, 33(7), 642-648.
DOI Scopus40 WoS42 Europe PMC32
2005 Ninio, D., Murphy, K., Howe, P., & Saint, D. (2005). Dietary fish oil protects against stretch-induced vulnerability to atrial fibrillation in a rabbit model. Journal of Cardiovascular Electrophysiology, 16(11), 1189-1194.
DOI Scopus88 WoS64 Europe PMC47
2005 Pugsley, M., Walker, M., & Saint, D. (2005). Block of Na+ and K+ currents in rat ventricular myocytes by quinacainol and quinidine. Clinical and Experimental Pharmacology and Physiology, 32(1-2), 60-65.
DOI Scopus11 WoS6 Europe PMC8
2004 Tan, J., Liu, W., & Saint, D. (2004). Differential expression of the mechanosensitive potassium channel TREK-1 in epicardial and endocardial myocytes in rat ventricle. Experimental Physiology, 89(3), 237-242.
DOI Scopus44 WoS42 Europe PMC33
2004 Liu, W., & Saint, D. (2004). Heterogeneous expression of tandem-pore K+ channel genes in adult and embryonic rat heart quantified by real-time polymerase chain reaction. Clinical and Experimental Pharmacology and Physiology, 31(3), 174-178.
DOI Scopus40 WoS44 Europe PMC30
2003 Honen, B., Saint, D., & Laver, D. (2003). Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid. Journal of Membrane Biology, 196(2), 95-103.
DOI Scopus45 WoS43 Europe PMC26
2002 Liu, W., & Saint, D. (2002). Validation of a quantitative method for real time PCR kinetics. Biochemical and Biophysical Research Communications, 294(2), 347-353.
DOI Scopus262 WoS250 Europe PMC188
2002 Tan, J., Liu, W., & Saint, D. (2002). Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP. Journal of Membrane Biology, 185(3), 201-207.
DOI Scopus30 WoS28 Europe PMC21
2002 Saint, D. (2002). Stretch-activated channels in the heart: Their role in arrhythmias and potential as antiarrhythmic drug targets. Drug Development Research, 55(1 Special Issue SI), 53-58.
DOI Scopus3 WoS4
2002 Honen, B., & Saint, D. (2002). Polyunsaturated dietary fats change the properties of calcium sparks in adult rat atrial myocytes. Journal of Nutritional Biochemistry, 13(6), 322-329.
DOI Scopus14 WoS11 Europe PMC7
2002 Honen, B., & Saint, D. (2002). Heterogeneity of the properties of I-Na in epicardial and endocardial cells of rat ventricle. Clinical and Experimental Pharmacology and Physiology, 29(3), 161-166.
DOI Scopus8 WoS8 Europe PMC7
2002 Liu, W., & Saint, D. (2002). A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Analytical Biochemistry, 302(1), 52-59.
DOI Scopus370 WoS364 Europe PMC267
2001 Ju, Y., & Saint, D. (2001). Subconductance states of the cardiac KATP channel revealed by partial block with glybenclamide. Pflugers Archiv-European Journal of Physiology, 442(6), 867-873.
DOI Scopus2 WoS2 Europe PMC2
2000 Leifert, W., Jahangiri, A., Saint, D., & McMurchie, E. (2000). Effects of dietary n-3 fatty acids on contractility, Na+ and K+ currents in a rat cardiomyocyte model of arrhythmia. Journal of Nutritional Biochemistry, 11(7-8), 382-392.
DOI Scopus26 WoS24 Europe PMC17
2000 Tan, H., & Saint, D. (2000). Interaction of lidocaine with the cardiac sodium channel Effects of low extracellular pH are consistent with an external blocking site. Life Sciences, 67(22), 2759-2766.
DOI Scopus8 WoS7 Europe PMC5
2000 Wong, V., Williams, D., Colby, C., & Saint, D. (2000). Correlation of O2 uptake rate and mitochondrial activity in carrot cell cultures exposed to laminar fluid shear. Biotechnology Letters, 22(24), 1919-1924.
DOI Scopus1 WoS1
1999 Saint, D., & Chung, S. (1999). Variability of channel subconductance states of the cardiac sodium channel induced by protease. Receptors and Channels, 6(4), 283-294.
Scopus1
1999 Leifert, W., McMurchie, E., & Saint, D. (1999). Inhibition of cardiac sodium currents in adult rat myocytes by n-3 polyunsaturated fatty acids. Journal of Physiology, 520(3), 671-679.
DOI Scopus90 WoS82 Europe PMC47
1998 Pugsley, M., Saint, D., Hayes, E., Kramer, D., & Walker, M. (1998). Sodium channel-blocking properties of spiradoline, a kappa receptor agonist, are responsible for its antiarrhythmic action in the rat. Journal of Cardiovascular Pharmacology, 32(6), 863-874.
DOI Scopus15 WoS14 Europe PMC10
1998 Saint, D., & Tang, Y. (1998). Propofol Block of Cardiac Sodium Currents in Rat Isolated Myocardial Cells Is Increased at Depolarized Resting Potentials. Clinical and Experimental Pharmacology and Physiology, 25(5), 336-340.
DOI Scopus15 WoS14 Europe PMC11
1998 Saint, D. (1998). Pacemaking in the heart: the interplay of ionic currents. Clinical and Experimental Pharmacology and Physiology, 25(10), 841-846.
DOI Scopus6 WoS5 Europe PMC4
1998 Saint, D. (1998). The effects of propofol on macroscopic and single channel sodium currents in rat ventricular myocytes. British Journal of Pharmacology, 124(124), 655-662.
DOI Scopus19 WoS22 Europe PMC16
1996 Ju, Y. K., Saint, D., & Gage, P. (1996). Tetrodotoxin sensitive inactivation resistant sodium channels in pacemaker cells influence heart rate. Pflugers Archiv European Journal of Physiology, 431(6), 868-875.
DOI
1996 Ju, Y., Saint, D., & Gage, P. (1996). Hypoxia increases persistent sodium current in rat ventricular myocytes. Journal of Physiology, 497(2), 337-347.
DOI

Book Chapters

Conference Papers

Year Citation
2014 Immanuel, S., Kohler, M., Kabir, M., Saint, D., & Baumert, M. (2014). Symbolic dynamics of respiratory cycle related sleep EEG in children with sleep disordered breathing. In Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Vol. 2014 (pp. 6016-6019). Chicago, IL: IEEE.
DOI
2014 Kabir, M., Immanuel, S., Tafreshi, R., Saint, D., & Baumert, M. (2014). Effect of resistive inspiratory and expiratory loading on cardio-respiratory interaction in healthy subjects. In Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference Vol. 2014 (pp. 710-713). Chicago, IL: IEEE.
DOI
2013 Immanuel, S., Kohler, M., Pamula, Y., Kabir, M., Saint, D., & Baumert, M. (2013). Increased variability in respiratory parameters heralds obstructive events in children with sleep disordered breathing. In Proceedings of the 35th Annual International Conference of the IEEE EMBS Vol. 2013 (pp. 2024-2027). USA: IEEE.
DOI Scopus1
2013 Immanuel, S., Pamula, Y., Kohler, M., Saint, D., & Baumert, M. (2013). Characterizing respiratory waveform regularity and associated thoraco-abdominal asynchrony during sleep using respiratory inductive plethysmography. In Proceedings of the 2013 IEEE Eighth International Conference on Intelligent Sensors, Sensor Networks and Information Processing, IEEE ISSNIP 2013 Vol. 1 (pp. 329-332). CD: IEEE.
DOI
2012 Immanuel, S., Kohler, M., Pamula, Y., Kabir, M., Saint, D., & Baumert, M. (2012). Thoraco-abdominal asynchrony in children during quiet sleep using Hilbert transform. In Proceedings of the 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2012 (pp. 3448-3451). CD: IEEE.
DOI Scopus4 WoS4
2011 Lau, D., Shipp, N., Thanigaimani, S., Neo, M., Wong, C., Brooks, A., . . . Sanders, P. (2011). Progressive atrial remodeling in chronic spontaneous hypertension. In EUROPEAN HEART JOURNAL Vol. 32 (pp. 472-473). OXFORD UNIV PRESS.
2011 Saint, D. (2011). MECHANICALLY INDUCED ARRHYTHMIAS: A NEGLECTED TARGET?. In HEART Vol. 97 (pp. 1 page). London, ENGLAND: B M J PUBLISHING GROUP.
DOI
2011 Kabir, M., Abbott, D., Saint, D., & Baumert, M. (2011). Effect of postural changes on cardiorespiratory coordination in humans. In Proceedings of ICSAP 2011 (pp. 76-80). CD: IEEE.
2010 Horton, D., Wiederman, S., & Saint, D. (2010). Lecture attendance, learning style and assessment outcome in physiology students. In The Education Research Group of Adelaid (pp. The Changing Face of Education, 24-25 September, 2010). Adelaide, Australia: The University of Adelaide.
2008 Lau, D., Mackenzie, L., Rajendram, A., Rao, M., Russell, C., Goddard, K., . . . Sanders, P. (2008). DEVELOPMENT AND CHARACTERISATION OF THE CARDIOVASCULAR CHANGES IN A LARGE ANIMAL MODEL OF HYPERTENSION. In HYPERTENSION Vol. 52 (pp. 170). Adelaide, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2006 Zhu, H., Yuan, S., & Saint, D. A. (2006). Expression of the 2-pore potassium channel TREK-2 in human heart. In JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Vol. 41 (pp. 746). Canberra, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
DOI WoS1
2005 Ball, C., Kennedy, J., Beltrame, J., & Saint, D. (2005). The effect of pravastatin on microvascular constrictor responses. In EUROPEAN HEART JOURNAL Vol. 26 (pp. 581). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2005 Mackenzie, L., Kelly, D., & Saint, D. (2005). Stretch differentially affects ventricular epicardial and endocardial action potential durations in the rat. In FASEB JOURNAL Vol. 19 (pp. A1636). San Diego, CA: FEDERATION AMER SOC EXP BIOL.
2005 Saint, D., Murphy, K., Howe, P., & Ninio, D. (2005). Dietary fish oil protects against stretch-induced atrial fibrillation in a rabbit model. In FASEB JOURNAL Vol. 19 (pp. A1631). San Diego, CA: FEDERATION AMER SOC EXP BIOL.
2005 Haipeng, Z., Mackenzie, L., & Saint, D. (2005). Expression of the stretch sentitive K+ channels TREK and TRAAK in human heart. In EUROPEAN HEART JOURNAL Vol. 26 (pp. 197). Stockholm, SWEDEN: OXFORD UNIV PRESS.
2005 Berryman, M., Coussens, S., Pamula, Y., Kennedy, J., Lushington, K., Shalizi, C., . . . Abbott, D. (2005). Nonlinear aspects of the EEG during sleep in children. In N. G. Stocks, D. Abbott, & R. P. Morse (Eds.), Proceedings of SPIE Vol 5841, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems III Vol. 5841 (pp. 40-48). Online: S P I E - International Society for Optical Engineering.
DOI Scopus5 WoS3
2004 Kelly, D., & Saint, D. (2004). Absence of mechano-electric feedback in isolated rat atrial tissue. In JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Vol. 37 (pp. 174). Brisbane, AUSTRALIA: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD.
2004 Honen, B., Saint, D., Van Helden, D., & Laver, D. (2004). The effects of fatty acids on SR calcium release channels from cardiac muscle.. In BIOPHYSICAL JOURNAL Vol. 86 (pp. 239A-240A). Baltimore, MD: BIOPHYSICAL SOCIETY.
2002 Saint, D., Tan, J., & Liu, W. (2002). Differential gene expression and current density of TREK-1 in rat ventricle: implications for MEF. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 544 (pp. 25S). UNIV LEEDS, LEEDS, ENGLAND: CAMBRIDGE UNIV PRESS.
2002 Pitz, I., Hall, L., Hansen, H., Varadan, V., Bertram, C., Maddocks, S., . . . Abbott, D. (2002). Trade-offs for wireless transcutaneous RF communication in biotelemetric applications. In D. V. Nicolau, & A. P. Lee (Eds.), Proceedings of SPIE Vol. 4937 Vol. 4937 (pp. 307-318). CDROM: SPIE.
DOI Scopus5 WoS5
2001 Pugsley, M., Saint, D., Abraham, S., Hayes, E., & Walker, M. (2001). The kappa-opioid agonist (+/-)PD117,302 is an antiarrhythmic drug in disguise. In FUNDAMENTAL & CLINICAL PHARMACOLOGY Vol. 15 (pp. 45). WILEY-BLACKWELL.

Conference Items

Patents

My total grant funding to date has been over $4.5 million, largely from the NHMRC and NHF, with me as principle researcher, or part of a small team.  In addition, I was part of a consortium awarded $1.3 million as an ARC LIEF grant (2005).   In the commercial sphere, I have been co-founder and CEO of start-up biotechnology  companies that have raised approx. $6 million in equity investment.  I’m currently CID on NHMRC Project grant 1108013 ($949,956: 2016-19).

 Large group teaching (traditional lecture format)

Date Course Title  Course Level/ Code
2006-2009

Biology: Human perspectives                                            

Biology 1201

2000- 2008 Dental students                
 
Dent I   
2000-present 2nd year BSc and Biomed Sci students                                                                                                Physiol 2510
2000-present

3rd year BSc and Biomed Sci students                                                                                            

Physiology III 
2007-present

1st year MBBS students ~100/class)                                                                                                       

MBBS 1

Small group teaching (Tutorials)

Date Course Title Course Level/ Code
 2000

2nd year Biomedical science students     

Biomedical Sci II 
2002

2nd year BSc students                                                                

Physiol II 
2001-present

3rd year BSC students ~75/class- in tutorial groups of 2 to 4          

Physiology in Action

Small group teaching (PBL format)

Date Course Title Course Level/ Code
2000, 2006

1st year medical students                                                                      

Med I
2002, 2003

3rd year medical students                                    

Med III  
2004, 2006

PBL case studies

Biomed Sci III 

Practical classes

Date Course Title Course Level/ Code
2000-present

Neuromuscular physiology practical ~70 1st year Dental students                                                          

Dent 1
2003 Research project based practical 10 2nd year Biomed Sci students                                                         Biomedical Sci II
2004,6

Cardiovascular practical classes.  ~45 2nd year Physiology students                                                    

Physiology II
2007-present

Respiration practical classes                                                                            

Physiology II

 Postgraduate Reviews

Date Course Title

2004, 2006

2009-present

Progress reviews with PhD students  to assess progress and facilitate timely completion: 3rd year students 1st year students

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2016 - 2017 Co-Supervisor Perinatal Programming of Metabolic Health in Guinea Pigs Doctor of Philosophy Doctorate Full Time Dr Dane Horton
2014 - 2018 Principal Supervisor Investigating the role of Toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury Doctor of Philosophy Doctorate Full Time Sam Man Lee
2011 - 2014 Co-Supervisor Polysomnographic signal processing for advanced diagnostics of paediatric sleep disordered breathing Doctor of Philosophy Doctorate Full Time Mrs Sarah Anita Immanuel
2011 - 2016 Co-Supervisor Cardiac Remodelling Hypertrophic Cardiomyopathy and Diabesity Doctor of Philosophy Doctorate Full Time Mr Wei Wen Lim
2010 - 2017 Principal Supervisor Atrial Electrophysiological and Structural Changes in Obesity & Diabetes Mellitus Doctor of Philosophy Doctorate Full Time Miss Melissa Neo
2010 - 2015 Co-Supervisor DNA Damage and Nutrient Status as Risk Factors for Mild Cognitive Impairment and Alzheimer's Disease Doctor of Philosophy Doctorate Full Time Miss Sau Lai Lee
2010 - 2013 Principal Supervisor The Modification of Heart Rate Variability in Normal, Overweight and Type 2 Diabetic Patients Doctor of Philosophy Doctorate Full Time Mr Nicholas Sjoberg
2009 - 2015 Principal Supervisor An Examination of the Nature of Sleep Fragmentation in Children with Upper Airway Obstruction Doctor of Philosophy Doctorate Full Time Mr Scott Coussens
2006 - 2010 Co-Supervisor Substrate for Atrial Fibrillation in Cardiomyopathies Doctor of Philosophy Doctorate Full Time Dr Dennis Lau
2005 - 2010 Co-Supervisor Calcium Channel Distribution in the Arterial Vascular Tree and its Relation to Function Doctor of Philosophy Doctorate Full Time Mrs Christine Smith
2003 - 2006 Principal Supervisor The Expression and Function of Stretch-Activated 2P-4TMD Potassium Channel in Heart Doctor of Philosophy Doctorate Full Time Mr Haipeng Zhu
2003 - 2007 Co-Supervisor DHA-Rich Fish Oil and Regular Moderate Exercise: A Combined Intervention to Improve Cardiovascular, Metabolic and Inflammatory Biomarkers in Obesity Doctor of Philosophy Doctorate Full Time Ms Alison Hill
2003 - 2008 Principal Supervisor Mechanoelectric Feedback in the Mammalian Heart Doctor of Philosophy Doctorate Full Time Mr Douglas Kelly
2001 - 2009 Principal Supervisor An Examination of the Role of Atrial Stretch in the Genesis of Atrial Fibrillation and the Antiarrhythmic Effects of Dietary Fish Oil Doctor of Philosophy Doctorate Full Time Mr Daniel Ninio
2000 - 2005 Co-Supervisor Gating of the CIC-1 Chloride Channel Doctor of Philosophy Doctorate Part Time Dr Michael Duffield
1999 - 2003 Principal Supervisor Dietary and Free n-3 Polyunsaturated Fatty Acids modify calcium handling mechanisms in the heart Doctor of Philosophy Doctorate Full Time Miss Bonny Honen
1999 - 2003 Principal Supervisor Mechanosensitive TREK-1 Channels in the Heart Doctor of Philosophy Doctorate Full Time Ms Hui Tan

Committee Memberships

Date Role Committee Institution Country
2013 - ongoing Representative INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCES United Kingdom
2010 - ongoing Member Australian Physiological Society (AuPS), and Australian Society for Biophysics (ASB) Australia
2010 - ongoing Chair Education Symposium Australian Physiological Society (AuPS) and Australian Society for Biophysics (ASB) Australia
2005 - ongoing Member School of Molecular and Biomedical Science Research Symposium University of Adelaide Australia
2005 - ongoing Representative INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCES United States
2000 - ongoing Chair Finding Workable Solutions (FWS) Australia

Memberships

Date Role Membership Country
2012 - ongoing Cardiac Society of Australia and New Zealand (FCSANZ) Australia
2011 - ongoing Member NHMRC translational council Australia
2010 - ongoing Council Australian Physiological Society (AuPS) Australia
2010 - 2014 Member International Society for Heart Research
2010 - ongoing Member British Pharmacological Society United Kingdom
2010 - ongoing Member American Physiological Society United States
2010 - ongoing Member South Australia Cardiovascular Research Network Australia
2010 - 2012 President International Society for Heart Research Australia
2003 - 2007 Secretary International Society for Heart Australia
2003 - 2007 Representative International Society for Heart Research Australia
2002 - ongoing Representative Australian Society for Biophysics Australia
2002 - 2007 Secretary Australian Physiological and Pharmacological Society Australia
2000 - ongoing Director Centre for Biomedical Engineering (CBME), Adelaide University Australia
2000 - ongoing Chair BioAngels Ltd.

Editorial Boards

Date Role Editorial Board Name Institution Country
2013 - ongoing Editor-In-chief American Institute of Mathematical Sciences Biophysics
Position
Professor
Phone
83133931
Fax
8313 3356
Campus
North Terrace
Building
Helen Mayo North Building, floor 4
Room Number
4 35a
Org Unit
Medical Sciences

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