Professor David Saint

David Saint
Professor
Adelaide Medical School
Faculty of Health and Medical Sciences

Current projects in the laboratory
• The mechanisms underlying mechanoelectric feedback and arrhythmias in cardiac tissue
• Cardioprotection using novel therapeutic targets
• The mechanisms underlying atrial fibrillation
• The use of heart rate variability (HRV) as a diagnostic marker, and mechanisms of HRV

Professor David Saint

Current projects in the laboratory
• The mechanisms underlying mechanoelectric feedback and arrhythmias in cardiac tissue
• Cardioprotection using novel therapeutic targets
• The mechanisms underlying atrial fibrillation
• The use of heart rate variability (HRV) as a diagnostic marker, and mechanisms of HRV

Appointments

Date Position Institution name
2005 Associate Professor University of Adelaide
2004 - 2006 CEO Verona Pharma Ltd
1999 - 2004 Senior Lecturer University of Adelaide
1996 - 1999 NH&MRC Senior Research Officer University of Adelaide
1996 - 1999 Visiting Fellow Australian National University
1995 - 1996 Senior Toxicologist Australian Government
1992 - 1995 Visiting Fellow Australian National University
1992 - 1995 NH&MRC Senior Research Officer University of Canberra
1987 - 1992 Research Fellow Australian National University
1982 - 1987 Post-Doctoral Fellow/Research Associate University of British Columbia

Awards and Achievements

Date Type Title Institution Name Amount
2012 Award The Executive Dean’s Prize for Excellence in Teaching University of Adelaide
2012 Award The Michael Roberts Excellence in Physiology Education Award Australian Physiological Society

Education

Date Institution name Country Title
2003 University of Adelaide Australia MBA (Advanced)
1978 - 1982 University of St. Andrews Scotland PhD
1973 - 1978 University of Leeds United Kingdom BSc (Hons)

Certifications

Date Title Institution name Country
2012 GAICD Australian Institute of Company Directors Australia

Research Interests

Cardiac, Respiratory and Vascular Health

Journals

Year Citation
2017 Horton, D., Saint, D., Owens, J., Gatford, K. & Kind, K. (2017). Use of the hyperinsulinemic euglycemic clamp to assess insulin sensitivity in guinea pigs: Dose response, partitioned glucose metabolism, and species comparisons. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 313, 1, 19-28.
10.1152/ajpregu.00028.2017
2016 Horton, D., Saint, D., Owens, J., Kind, K. & Gatford, K. (2016). Spontaneous intrauterine growth restriction due to increased litter size in the Guinea pig programmes postnatal growth, appetite and adult body composition. Journal of Developmental Origins of Health and Disease, 7, 5, 548-562.
10.1017/S2040174416000295
2016 Neo, M., Morris, D., Kuklik, P., Lau, D., Dimitri, H., Lim, W. ... Saint, D. (2016). Simultaneous conduction mapping and intracellular membrane potential recording in isolated atria. Canadian Journal of Physiology and Pharmacology, 94, 5, 563-569.
10.1139/cjpp-2015-0194
2016 Lim, W., Baumert, M., Neo, M., Kuklik, P., Ganesan, A., Lau, D. ... Saint, D. (2016). Slowed atrial and atrioventricular conduction and depressed HRV in a murine model of hypertrophic cardiomyopathy. Clinical and Experimental Pharmacology and Physiology, 43, 1, 95-101.
10.1111/1440-1681.12498
2016 Lee, S., Hutchinson, M. & Saint, D. (2016). The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology and Physiology, 43, 9, 864-871.
10.1111/1440-1681.12602
2015 Pugsley, M., Saint, D., Hayes, E., Abraham, S. & Walker, M. (2015). An examination of the cardiac actions of PD117,302, a κ-opioid receptor agonist. European Journal of Pharmacology, 761, 330-340.
10.1016/j.ejphar.2015.06.018
2015 Immanuel, S., Kohler, M., Martin, A., Kennedy, J., Pamula, Y., Kabir, M. ... Baumert, M. (2015). Increased thoracoabdominal asynchrony during breathing periods free of discretely scored obstructive events in children with upper airway obstruction. Sleep and Breathing, 19, 1, 65-71.
10.1007/s11325-014-0963-3
2015 Saint, D., Horton, D., Yool, A. & Elliott, A. (2015). A progressive assessment strategy improves student learning and perceived course quality in undergraduate physiology. Advances in Physiology Education, 39, 3, 218-222.
10.1152/advan.00004.2015
2015 Lee, S., Hutchinson, M., Staikopoulos, V. & Saint, D. (2015). Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. International Journal of Cardiology, 190, 353-359.
10.1016/j.ijcard.2015.04.120
2014 Coussens, S., Baumert, M., Kohler, M., Martin, J., Kennedy, D., Lushington, K. ... Pamula, Y. (2014). Movement distribution: a new measure of sleep fragmentation in children with upper airway obstruction. Sleep, 37, 12, 2025-2034.
10.5665/sleep.4264
2014 Saint, D. (2014). Finding a niche in a changing sociological, technological and scientific world-AIMS Biophysics. AIMS Biophysics, 1, 1, 49-50.
10.3934/biophy.2014.1.49
2014 Immanuel, S., Pamula, Y., Kohler, M., Martin, J., Kennedy, D., Saint, D. & Baumert, M. (2014). Respiratory cycle-related electroencephalographic changes during sleep in healthy children and in children with sleep disordered breathing. Sleep, 37, 8, 1353-1361.
10.5665/sleep.3930
2014 Benoist, D., Stones, R., Benson, A., Fowler, E., Drinkhill, M., Hardy, M. ... White, E. (2014). Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline. Progress in Biophysics and Molecular Biology, 115, 2-3, 162-172.
10.1016/j.pbiomolbio.2014.06.008
2014 Immanuel, S., Pamula, Y., Kohler, M., Martin, J., Kennedy, D., Nalivaiko, E. ... Baumert, M. (2014). Heartbeat evoked potentials during sleep and daytime behavior in children with sleep disordered breathing. American Journal of Respiratory and Critical Care Medicine, 190, 10, 1149-1157.
10.1164/rccm.201405-0920oc
2014 Kelly, D., Mackenzie, L. & Saint, D. (2014). Mechanoelectric feedback does not contribute to the Frank-Starling relation in the rat and guinea pig heart. AIMS Biophysics, 1, 1, 16-30.
10.3934/biophy.2014.1.16
2013 Weiss, S., Dahlstrom, J. & Saint, D. (2013). Riluzole reduces arrhythmias and myocardial damage induced by coronary occlusion in anaesthetized pigs. Clinical and Experimental Pharmacology and Physiology, 40, 12, 856-863.
10.1111/1440-1681.12175
2013 Lau, D., Shipp, N., Kelly, D., Thanigaimani, S., Neo, M., Kuklik, P. ... Sanders, P. (2013). Atrial arrhythmia in ageing spontaneously hypertensive rats: Unraveling the substrate in hypertension and ageing. PLoS One, 8, 8, 1-10.
10.1371/journal.pone.0072416
2013 Alasady, M., Shipp, N., Brooks, A., Lim, H., Lau, D., Barlow, D. ... Sanders, P. (2013). Myocardial infarction and atrial fibrillation importance of atrial ischemia. Circulation, Arrhythmia & Electrophysiology (Print), 6, 4, 738-745.
10.1161/CIRCEP.113.000163
2013 Curtis, M., Hancox, J., Farkas, A., Wainwright, C., Stables, C., Saint, D. ... Walker, M. (2013). The lambeth conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology & Therapeutics, 139, 2, 213-248.
10.1016/j.pharmthera.2013.04.008
2012 Kabir, M., Saint, D., Abbott, D. & Baumert, M. (2012). Effect of postural changes on cardiorespiratory coordination in humans. Computers & Electrical Engineering, 4, 3, 274-277.
2012 Benoist, D., Stones, R., Drinkhill, M., Benson, A., Yang, Z., Cassan, C. ... White, E. (2012). Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. American Journal of Physiology-Heart and Circulatory Physiology, 302, 11, H2381-H2395.
10.1152/ajpheart.01084.2011
2012 Dimitri, H., Ng, M., Brooks, A., Kuklik, P., Stiles, M., Lau, D. ... Sanders, P. (2012). Atrial remodeling in obstructive sleep apnea: implications for atrial fibrillation. Heart Rhythm, 9, 3, 321-327.
10.1016/j.hrthm.2011.10.017
2012 Kim, D., White, E. & Saint, D. (2012). Increased mechanically-induced ectopy in the hypertrophied heart. Progress in Biophysics & Molecular Biology, 110, 2-3, 331-339.
10.1016/j.pbiomolbio.2012.07.004
2012 Immanuel, S., Pamula, Y., Kohler, M., Martin, A., Kennedy, J., Kabir, M. ... Baumert, M. (2012). Respiratory timing and variability during sleep in children with sleep-disordered breathing. Journal of Applied Physiology, 113, 10, 1635-1642.
10.1152/japplphysiol.00756.2012
2012 Horton, D., Wiederman, S. & Saint, D. (2012). Assessment outcome is weakly correlated with lecture attendance: influence of learning style and use of alternative materials. Advances in Physiology Education, 36, 2, 108-115.
10.1152/advan.00111.2011
2011 Lau, D., Psaltis, P., Mackenzie, L., Kelly, D., Carbone, A., Worthington, M. ... Sanders, P. (2011). Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort. Journal of Cardiovascular Electrophysiology, 22, 2, 175-182.
10.1111/j.1540-8167.2010.01851.x
2011 Sjoberg, N. & Saint, D. (2011). A single 4 mg dose of nicotine decreases heart rate variability in healthy nonsmokers: Implications for smoking cessation programs. Nicotene & Tobacco Research, 13, 5, 369-372.
10.1093/ntr/ntr004
2011 Kabir, M., Saint, D., Nalivaiko, E., Abbott, D. & Baumert, M. (2011). Time delay correction of the synchrogram for optimized detection of cardiorespiratory coordination. Medical & Biological Engineering & Computing, 49, 11, 1249-1259.
10.1007/s11517-011-0822-3
2011 Saint, D. (2011). Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing. Progress in Biophysics & Molecular Biology, 107, 1, 4-10.
10.1016/j.pbiomolbio.2011.07.001
2011 Lau, D., Psaltis, P., Carbone, A., Kelly, D., Mackenzie, L., Worthington, M. ... Sanders, P. (2011). Atrial protective effects of n-3 polyunsaturated fatty acids: A long-term study in ovine chronic heart failure. Heart Rhythm, 8, 4, 575-582.
10.1016/j.hrthm.2010.12.009
2011 Kabir, M., Saint, D., Nalivaiko, E., Abbott, D., Voss, A. & Baumert, M. (2011). Quantification of cardiorespiratory interactions based on joint symbolic dynamics. Annals of Biomedical Engineering, 39, 10, 2604-2614.
10.1007/s10439-011-0332-3
2011 Beig, M., Callister, R., Saint, D., Bondarenko, E., Walker, F., Day, T. & Nalivaiko, E. (2011). Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac arrhythmias in rats. Clinical and Experimental Pharmacology and Physiology, 38, 1, 19-26.
10.1111/j.1440-1681.2010.05456.x
2011 Sjoberg, N., Brinkworth, G., Wycherley, T., Noakes, M. & Saint, D. (2011). Moderate weight loss improves heart rate variability in overweight and obese adults with type 2 diabetes. Journal of Applied Physiology, 110, 4, 1060-1064.
10.1152/japplphysiol.01329.2010
2010 Weiss, S., Benoist, D., White, E., Teng, W. & Saint, D. (2010). Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current. British Journal of Pharmacology, 160, 5, 1072-1082.
10.1111/j.1476-5381.2010.00766.x
2010 Sjoberg, N., Milte, C., Buckley, J., Howe, P., Coates, A. & Saint, D. (2010). Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation. British Journal of Nutrition, 103, 2, 243-248.
10.1017/S000711450999153X
2010 Lau, D., Mackenzie, L., Rajendram, A., Psaltis, P., Kelly, D., Spyropoulos, P. ... Sanders, P. (2010). Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model. Blood Pressure, 19, 2, 119-125.
10.3109/08037050903576767
2010 Lau, D., Mackenzie, L., Shipp, N., Kuklik, P., Dimitri, H., Lobb, B. ... Sanders, P. (2010). Feasibility of high-density electrophysiological study using multiple-electrode array in isolated small animal atria. Clinical and Experimental Pharmacology and Physiology, 37, 10, 1023-1027.
10.1111/j.1440-1681.2010.05435.x
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Worthington, M., Rajendram, A. ... Sanders, P. (2010). Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model. Heart Rhythm, 7, 3, 396-404.
10.1016/j.hrthm.2009.11.031
2010 Lau, D., Mackenzie, L., Kelly, D., Psaltis, P., Brooks, A., Worthington, M. ... Sanders, P. (2010). Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model. Heart Rhythm, 7, 9, 1282-1290.
10.1016/j.hrthm.2010.05.010
2010 Weiss, S. & Saint, D. (2010). The persistent sodium current blocker Riluzole Is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction. PLoS One, 5, 11, 1-13.
10.1371/journal.pone.0014103
2009 Smith, C., Wilson, D., Turner, S., Saint, D. & Beltrame, J. (2009). Heterogeneity of L- and T-channels in the vasculature: Rationale for the efficacy of combined L- and T-blockade. Hypertension, 53, 4, 654-660.
10.1161/HYPERTENSIONAHA.108.125831
2009 Wilson, D., Smith, C., Turner, S., Saint, D. & Beltrame, J. (2009). Response to Is Combined L- and T-Channel Blockade Better than L-Channel Blockade in Therapy?. Hypertension, 54, 1, E4-E4.
10.1161/HYPERTENSIONAHA.109.133850
2009 Saint, D. (2009). Persistent (current) in the face of adversity ... A new class of cardiac anti-ischaemic compounds on the horizon?. British Journal of Pharmacology, 156, 2, 211-213.
10.1111/j.1476-5381.2008.00077.x
2008 Saint, D. (2008). The cardiac persistent sodium current: an appealing therapeutic target?. British Journal of Pharmacology, 153, 6, 1133-1142.
10.1038/sj.bjp.0707492
2008 Ninio, D., Hill, A., Howe, P., Buckley, J. & Saint, D. (2008). Docosahexaenoic acid-rich fish oil improves heart rate variability and heart rate responses to exercise in overweight adults. British Journal of Nutrition, 100, 5, 1097-1103.
10.1017/S0007114508959225
2008 Jones, I., Ricciardi, L., Hall, L., Hansen, H., Varadan, V., Bertram, C. ... Abbott, D. (2008). Wireless RF communication in biomedical applications. Smart Materials & Structures, 17, 1, WWW 1-WWW 10.
10.1088/0964-1726/17/1/015050
2008 Ninio, D. & Saint, D. (2008). The role of stretch-activated channels in atrial fibrillation and the impact of intracellular acidosis. Progress in Biophysics & Molecular Biology, 97, 2-3, 401-416.
10.1016/j.pbiomolbio.2008.02.016
2008 Smith, C., Saint, D., Wilson, D. & Beltrame, J. (2008). Heterogeneity in vasomotor responses to L- and T-type calcium channel blockers. Journal of Molecular and Cellular Cardiology, 44, 4, 817-818.
10.1016/j.yjmcc.2008.02.254
2008 Murphy, K., Saint, D. & Howe, P. (2008). Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits. Journal of the American College of Nutrition, 27, 4, 476-484.
10.1080/07315724.2008.10719728
2006 Saint, D. (2006). The role of the persistent Na+ current during cardiac ischemia and hypoxia. Journal of Cardiovascular Electrophysiology, 17, 1, S96-S103.
10.1111/j.1540-8167.2006.00390.x
2006 Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D. & James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1761, 12, 1443-1449.
10.1016/j.bbalip.2006.09.003
2006 Kelly, D., Mackenzie, L., Hunter, P., Smaill, B. & Saint, D. (2006). Gene expression of stretch-activated channels and mechanoelectric feedback in the heart. Clinical and Experimental Pharmacology and Physiology, 33, 7, 642-648.
10.1111/j.1440-1681.2006.04392.x
2006 Ninio, D. & Saint, D. (2006). Passive pericardial constraint protects against stretch-induced vulnerability to atrial fibrillation in rabbits. American Journal of Physiology-Heart and Circulatory Physiology, 291, 5, H2547-H2549.
10.1152/ajpheart.01248.2005
2005 Ninio, D., Murphy, K., Howe, P. & Saint, D. (2005). Dietary fish oil protects against stretch-induced vulnerability to atrial fibrillation in a rabbit model. Journal of Cardiovascular Electrophysiology, 16, 11, 1189-1194.
10.1111/j.1540-8167.2005.50007.x
2005 Pugsley, M., Walker, M. & Saint, D. (2005). Block of Na+ and K+ currents in rat ventricular myocytes by quinacainol and quinidine. Clinical and Experimental Pharmacology and Physiology, 32, 1-2, 60-65.
10.1111/j.1440-1681.2005.04149.x
2004 Liu, W. & Saint, D. (2004). Heterogeneous expression of tandem-pore K+ channel genes in adult and embryonic rat heart quantified by real-time polymerase chain reaction. Clinical and Experimental Pharmacology and Physiology, 31, 3, 174-178.
10.1111/j.1440-1681.2004.03964.x
2004 Tan, J., Liu, W. & Saint, D. (2004). Differential expression of the mechanosensitive potassium channel TREK-1 in epicardial and endocardial myocytes in rat ventricle. Experimental Physiology, 89, 3, 237-242.
10.1113/expphysiol.2003.027052
2003 Honen, B., Saint, D. & Laver, D. (2003). Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid. Journal of Membrane Biology, 196, 2, 95-103.
10.1007/s00232-003-0628-9
2002 Liu, W. & Saint, D. (2002). Validation of a quantitative method for real time PCR kinetics. Biochemical and Biophysical Research Communications, 294, 2, 347-353.
10.1016/S0006-291X(02)00478-3
2002 Tan, J., Liu, W. & Saint, D. (2002). Trek-like potassium channels in rat cardiac ventricular myocytes are activated by intracellular ATP. Journal of Membrane Biology, 185, 3, 201-207.
10.1007/s00232-001-0123-0
2002 Saint, D. (2002). Stretch-activated channels in the heart: Their role in arrhythmias and potential as antiarrhythmic drug targets. Drug Development Research, 55, 1 Special Issue SI, 53-58.
10.1002/ddr.10039
2002 Liu, W. & Saint, D. (2002). A new quantitative method of real time reverse transcription polymerase chain reaction assay based on simulation of polymerase chain reaction kinetics. Analytical Biochemistry, 302, 1, 52-59.
10.1006/abio.2001.5530
2002 Honen, B. & Saint, D. (2002). Polyunsaturated dietary fats change the properties of calcium sparks in adult rat atrial myocytes. Journal of Nutritional Biochemistry, 13, 6, 322-329.
10.1016/S0955-2863(02)00175-4
2002 Honen, B. & Saint, D. (2002). Heterogeneity of the properties of I-Na in epicardial and endocardial cells of rat ventricle. Clinical and Experimental Pharmacology and Physiology, 29, 3, 161-166.
10.1046/j.1440-1681.2002.03620.x
2001 Ju, Y. & Saint, D. (2001). Subconductance states of the cardiac KATP channel revealed by partial block with glybenclamide. Pflugers Archiv-European Journal of Physiology, 442, 6, 867-873.
10.1007/s004240100603
2000 Leifert, W., Jahangiri, A., Saint, D. & McMurchie, E. (2000). Effects of dietary n-3 fatty acids on contractility, Na+ and K+ currents in a rat cardiomyocyte model of arrhythmia. Journal of Nutritional Biochemistry, 11, 7-8, 382-392.
10.1016/S0955-2863(00)00094-2
2000 Wong, V., Williams, D., Colby, C. & Saint, D. (2000). Correlation of O2 uptake rate and mitochondrial activity in carrot cell cultures exposed to laminar fluid shear. Biotechnology Letters, 22, 24, 1919-1924.
10.1023/A:1026752418909
2000 Tan, H. & Saint, D. (2000). Interaction of lidocaine with the cardiac sodium channel Effects of low extracellular pH are consistent with an external blocking site. Life Sciences, 67, 22, 2759-2766.
10.1016/S0024-3205(00)00855-9
1999 Saint, D. & Chung, S. (1999). Variability of channel subconductance states of the cardiac sodium channel induced by protease. Receptors and Channels, 6, 4, 283-294.
1999 Leifert, W., McMurchie, E. & Saint, D. (1999). Inhibition of cardiac sodium currents in adult rat myocytes by n-3 polyunsaturated fatty acids. Journal of Physiology, 520, 3, 671-679.
10.1111/j.1469-7793.1999.00671.x
1998 Saint, D. (1998). The effects of propofol on macroscopic and single channel sodium currents in rat ventricular myocytes. British Journal of Pharmacology, 124, 124, 655-662.
10.1038/sj.bjp.0701876
1998 Saint, D. (1998). Pacemaking in the heart: the interplay of ionic currents. Clinical and Experimental Pharmacology and Physiology, 25, 10, 841-846.
10.1111/j.1440-1681.1998.tb02165.x
1998 Saint, D. & Tang, Y. (1998). Propofol Block of Cardiac Sodium Currents in Rat Isolated Myocardial Cells Is Increased at Depolarized Resting Potentials. Clinical and Experimental Pharmacology and Physiology, 25, 5, 336-340.
10.1111/j.1440-1681.1998.tb02360.x
1998 Pugsley, M., Saint, D., Hayes, E., Kramer, D. & Walker, M. (1998). Sodium channel-blocking properties of spiradoline, a kappa receptor agonist, are responsible for its antiarrhythmic action in the rat. Journal of Cardiovascular Pharmacology, 32, 6, 863-874.
10.1097/00005344-199812000-00002
1996 Ju, Y., Saint, D. & Gage, P. (1996). Hypoxia increases persistent sodium current in rat ventricular myocytes. Journal of Physiology, 497, 2, 337-347.
10.1113/jphysiol.1996.sp021772
1996 Ju, Y. K., Saint, D. & Gage, P. (1996). Tetrodotoxin sensitive inactivation resistant sodium channels in pacemaker cells influence heart rate. Pflugers Archiv European Journal of Physiology, 431, 6, 868-875.
10.1007/s004240050079

Book Chapters

Year Citation
2003 Saint, D. (2003). The role of cardiac pacemaker currents in antiarrythmic drug discovery. In M. K. Pugsley (Ed.), Cardiac Drug Development Guide (pp. 27-46). 999 Riverview Drive, Suite 208, Totowa, NJ 07512: Humana Press.
10.1226/1588290972
1997 Saint, D. (1997). Single channel recording and data analysis. In Methods in Cardiac electrophysiology (pp. 63-87). CRC Press Inc.

Conference Papers

Year Citation
2014 Immanuel, S., Kohler, M., Kabir, M., Saint, D. & Baumert, M. (2014). Symbolic dynamics of respiratory cycle related sleep EEG in children with sleep disordered breathing. 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC). Chicago, IL.
10.1109/EMBC.2014.6945000
2014 Kabir, M., Immanuel, S., Tafreshi, R., Saint, D. & Baumert, M. (2014). Effect of resistive inspiratory and expiratory loading on cardio-respiratory interaction in healthy subjects. 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC). Chicago, IL.
10.1109/EMBC.2014.6943689
2013 Immanuel, S., Kohler, M., Pamula, Y., Kabir, M., Saint, D. & Baumert, M. (2013). Increased variability in respiratory parameters heralds obstructive events in children with sleep disordered breathing. The Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Osaka.
10.1109/EMBC.2013.6609928
2013 Immanuel, S., Pamula, Y., Kohler, M., Saint, D. & Baumert, M. (2013). Characterizing respiratory waveform regularity and associated thoraco-abdominal asynchrony during sleep using respiratory inductive plethysmography. International Conference on Intelligent Sensors, Sensor Networks and Information Processing (ISSNIP). Melbourne.
10.1109/ISSNIP.2013.6529811
2012 Immanuel, S., Kohler, M., Pamula, Y., Kabir, M., Saint, D. & Baumert, M. (2012). Thoraco-abdominal asynchrony in children during quiet sleep using Hilbert transform. The Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). San Diego.
10.1109/EMBC.2012.6346707
2011 Kabir, M., Abbott, D., Saint, D. & Baumert, M. (2011). Effect of postural changes on cardiorespiratory coordination in humans. IEEE International Conference on Signal Acquisition and Processing. Singapore.
2011 Lau, D., Shipp, N., Thanigaimani, S., Neo, M., Wong, C., Brooks, A. ... Sanders, P. (2011). Progressive atrial remodeling in chronic spontaneous hypertension.
2011 Saint, D. (2011). MECHANICALLY INDUCED ARRHYTHMIAS: A NEGLECTED TARGET?. 2010 Autumn Meeting on British-Society-for-Cardiovascular-Research. London, ENGLAND.
10.1136/hrt.2010.213496.18
2010 Horton, D., Wiederman, S. & Saint, D. (2010). Lecture attendance, learning style and assessment outcome in physiology students. ERGA Conference. Adelaide, Australia.
2008 Lau, D., Mackenzie, L., Rajendram, A., Rao, M., Russell, C., Goddard, K. ... Sanders, P. (2008). DEVELOPMENT AND CHARACTERISATION OF THE CARDIOVASCULAR CHANGES IN A LARGE ANIMAL MODEL OF HYPERTENSION. 29th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia. Adelaide, AUSTRALIA.
2005 Berryman, M., Coussens, S., Pamula, Y., Kennedy, J., Lushington, K., Shalizi, C. ... Abbott, D. (2005). Nonlinear aspects of the EEG during sleep in children. Fluctuations and Noise. N. G. Stocks, D. Abbott & R. P. Morse (Eds.) Austin, Texas, USA.
10.1117/12.622380
2002 Pitz, I., Hall, L., Hansen, H., Varadan, V., Bertram, C., Maddocks, S. ... Abbott, D. (2002). Trade-offs for wireless transcutaneous RF communication in biotelemetric applications. International Symposium on Smart Materials, Nano- and Micro-Smart Systems. D. V. Nicolau & A. P. Lee (Eds.) Melbourne, Australia.
10.1117/12.476427

Conference Items

Year Citation
2009 Lau, D. H., Mackenzie, L., Kelly, D. J., Psaltis, P. J., Worthington, M., Rajendram, A. ... Sanders, P. (2009). Hypertension and atrial fibrillation: a long term study of remodeling in a conscious ovine model. 82nd Scientific Session of the American Heart Association. Orlando, FL.

Patents

Year Citation
2006 Saint, D., Zhu, H. & Yuan, S.; (2006); Potassium channels in human heart;

My total grant funding to date has been over $4.5 million, largely from the NHMRC and NHF, with me as principle researcher, or part of a small team.  In addition, I was part of a consortium awarded $1.3 million as an ARC LIEF grant (2005).   In the commercial sphere, I have been co-founder and CEO of start-up biotechnology  companies that have raised approx. $6 million in equity investment.  I’m currently CID on NHMRC Project grant 1108013 ($949,956: 2016-19).

 Large group teaching (traditional lecture format)

Date Course Title  Course Level/ Code
2006-2009

Biology: Human perspectives                                            

Biology 1201

2000- 2008 Dental students                
 
Dent I   
2000-present 2nd year BSc and Biomed Sci students                                                                                                Physiol 2510
2000-present

3rd year BSc and Biomed Sci students                                                                                            

Physiology III 
2007-present

1st year MBBS students ~100/class)                                                                                                       

MBBS 1

Small group teaching (Tutorials)

Date Course Title Course Level/ Code
 2000

2nd year Biomedical science students     

Biomedical Sci II 
2002

2nd year BSc students                                                                

Physiol II 
2001-present

3rd year BSC students ~75/class- in tutorial groups of 2 to 4          

Physiology in Action

Small group teaching (PBL format)

Date Course Title Course Level/ Code
2000, 2006

1st year medical students                                                                      

Med I
2002, 2003

3rd year medical students                                    

Med III  
2004, 2006

PBL case studies

Biomed Sci III 

Practical classes

Date Course Title Course Level/ Code
2000-present

Neuromuscular physiology practical ~70 1st year Dental students                                                          

Dent 1
2003 Research project based practical 10 2nd year Biomed Sci students                                                         Biomedical Sci II
2004,6

Cardiovascular practical classes.  ~45 2nd year Physiology students                                                    

Physiology II
2007-present

Respiration practical classes                                                                            

Physiology II

 Postgraduate Reviews

Date Course Title

2004, 2006

2009-present

Progress reviews with PhD students  to assess progress and facilitate timely completion: 3rd year students 1st year students

 Postdoctoral fellows

Date Researcher Name
2007 - 2009 Dr Wang Teng, Visiting Scientist from Wuhan University, PRC
2005 - 2007 Dr Jacob Ross, CJ Martin Fellow
2004 - 2006 Dr Shi-Yong Yuan, Postdoctoral Fellow
2003 - 2004

Dr Wang Xi, Visiting Postdoctoral Scientist from Wuhan University, PRC

2003 - 2006 Dr Lorraine Mackenzie, Peter Doherty Fellow
2001 - 2004 Dr Weihong Liu, Postdoctoral Fellow

PhD Students 

Date Student Name My Role Career Progression
2013 Sam Lee Principal  
2012 - 2015 Sarah Immanuel Co-supervisor  
2011 - 2016 Wei Wen Lim       Co-supervisor  
2010 - present Melissa Neo Principal  
2010 -  David Morris Principal Postgraduate medicine
2009 - 2014 Lee, Sau Lai Co-supervisor  
2010  -  Steven Weiss                                                                    Co-supervisor (based at ANU- now private consultant)
2007 - 2010

Nicholas Sjoberg             

Principal supervisor Postgraduate Medicine
2006 - 2010 Dennis Lau Co-supervisor Clinical Research in Cardiology
2005 - 2008 Christine Ball Co-supervisor Entered teacher training
2003 -  Scott Coussens Principal  
2003 - 2006 Haipeng Zhu Principal Research appointment in USA
2002 - 2007 Alison Hill Co-supervisor Postdoctoral position, Penn State College
2002 - 2007 Douglas Kelly Principal  Post Doc RA, Uni of Adelaide
2001 - 2007 Daniel Ninio Sole supervisor Cardiologist, QEH, Adelaide
2000 - 2005 Michael Duffield Co-supervisor Research position at Uni of Adelaide
1999 - 2002 Bonny Honen Sole supervisor Postdoctoral position, Uni Newcastle
1999 - 2002 Joy Tan Sole supervisor Postdoctoral position, Uni NSW
1999 - 2001 Wayne Leifert Co-supervisor Employed as Res. Scientist, CSIRO
1999 - 2001 Victor Tai Wong Co-supervisor Employed in Biotech industry, Singapore

Honours Students

Date Student Name Career Progression
2014 - 2015 Kat Van Rooyen  
2013 James Garlick  
2013 Sam Lee                Progressed to PhD with me
2012 Laura Casey Gap year
2011 Jennifer Glaetzer Postgraduate medicine
2010 Julia Kim Clinical cardiac technician
2009 Mellisa Neo Progressed to PhD with me
2009 David Morris Progressed to PhD with me
2006 Nick Sjoberg Progressed to PhD with me, then postgrad medicine
2004 Christine Ball Progressed to PhD with me as co-supervisor
2004 Nader Ghaffari Progressed to PhD at Queen Elizabeth Hospital
2003 Scott Coussens Progressed to PhD with me
2002 Ryan Potter Further study: Physiotherapy
1999 Toby Kelly Employed in Pharmaceutical Industry
1998 Bonny Honen Progressed to PhD with me
1997 Kieron Thomson Further study: Medicine at University of Sydney

Memberships

Date Role Membership Country
2012 - ongoing Cardiac Society of Australia and New Zealand (FCSANZ) Australia
2011 - ongoing Member NHMRC translational council Australia
2010 - 2014 Member International Society for Heart Research
2010 - ongoing Member American Physiological Society United States
2010 - ongoing Member British Pharmacological Society United Kingdom
2010 - ongoing Member South Australia Cardiovascular Research Network Australia
2010 - 2012 President International Society for Heart Research Australia
2010 - ongoing Council Australian Physiological Society (AuPS) Australia
2003 - 2007 Representative International Society for Heart Research Australia
2003 - 2007 Secretary International Society for Heart Australia
2002 - 2007 Secretary Australian Physiological and Pharmacological Society Australia
2002 - ongoing Representative Australian Society for Biophysics Australia
2000 - ongoing Chair BioAngels Ltd.
2000 - ongoing Director Centre for Biomedical Engineering (CBME), Adelaide University Australia

Committee Memberships

Date Role Committee Institution Country
2013 - ongoing Representative INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCES United Kingdom
2010 - ongoing Chair Education Symposium Australian Physiological Society (AuPS) and Australian Society for Biophysics (ASB) Australia
2010 - ongoing Member Australian Physiological Society (AuPS), and Australian Society for Biophysics (ASB) Australia
2005 - ongoing Representative INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCES United States
2005 - ongoing Member School of Molecular and Biomedical Science Research Symposium University of Adelaide Australia
2000 - ongoing Chair Finding Workable Solutions (FWS) Australia

Editorial Boards

Date Role Editorial Board Name Country
2013 - ongoing Editor-In-chief American Institute of Mathematical Sciences Biophysics
Position
Professor
Phone
83133931
Fax
8313 3356
Campus
North Terrace
Building
Medical School North
Room Number
4 35a
Org Unit
Medical Sciences

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