Craig Wallington-Beddoe
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Wallington-Beddoe is a NHMRC Research Fellow at the Centre for Cancer Biology, University of South Australia, Senior Lecturer at Flinders University and a Consultant Clinical Haematologist at Flinders Medical Centre. After completing specialist medical qualifications (FRACP/FRCPA) in the discipline of haematology at Westmead Hospital, Sydney, in 2009, Dr Wallington-Beddoe undertook PhD studies at The University of Sydney from 2010 to 2012. His work sought to investigate novel therapeutic strategies for acute lymphoblastic leukaemia (ALL) and resulted in several high impact publications and numerous national and international high profile conference presentations. In recognition of this work, Dr Wallington-Beddoe was awarded the 2012 Haematology Society of Australia and New Zealand Albert Baikie Memorial Medal and New Investigator Grant. He relocated to Adelaide in 2013 to undertake post-doctoral research, investigating how certain lipids can be targeted in myeloma to enhance current therapies, and was shortly thereafter awarded an Australian Government NHMRC Peter Doherty Research Fellowship and also a Mary Overton Royal Adelaide Hospital Research Fellowship. He plans to continue an active research role in myeloma through his University affiliations and recent hospital appointment at Flinders Medical Centre. Being a basic science researcher and clinical haematologist, Dr Wallington-Beddoe links and translates basic research to the clinic. Together with his pivotal role in directing haematology clinical trials, patients receive integrated and comprehensive care for their condition in a supportive and caring environment.
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Appointments
Date Position Institution name 2015 Consultant Haematologist QE Specialist Centre 2015 Clinical Senior Lecturer The University of Adelaide 2014 NHMRC Post-Doctoral Research Fellow University of South Australia 2013 Consultant Haematologist Clinpath Laboratories, Sonic Healthcare -
Education
Date Institution name Country Title — The University of Sydney Australia BSc (Hons) — The University of Sydney Australia MB BS (Hons) — The University of Adelaide Australia GradDip Biostat — The University of Sydney Australia PhD -
Postgraduate Training
Date Title Institution Country — FRACP The Royal Australasian College of Physicians Australia — FRCPA The Royal College of Pathologists of Australasia Australia
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Journals
Year Citation 2019 Wallington-Beddoe, C., Xie, V., Tong, D., Powell, J., Lewis, A., Davies, L., . . . Bendall, L. (2019). Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia. British Journal of Haematology, 184(3), 443-447.
2019 Bennett, M., Wallington-Beddoe, C., & Pitson, S. (2019). Sphingolipids and the unfolded protein response. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(10), 1483-1494.
2018 Lewis, A. C., Wallington-Beddoe, C. T., Powell, J. A., & Pitson, S. M. (2018). Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies. Cell Death Discovery, 5(1), 4.
Scopus3 WoS4 Europe PMC22018 Xie, V., Tong, D., Wallington-Beddoe, C. T., Bradstock, K. F., & Bendall, L. J. (2018). Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. Biomarker Research, 6(6), 1-7.
2018 Wallington-Beddoe, C., Sobieraj-Teague, M., Kuss, B., & Pitson, S. (2018). Resistance to proteasome inhibitors and other targeted therapies in myeloma. British Journal of Haematology, 182(1), 11-28.
Scopus9 WoS9 Europe PMC62017 Powell, J., Lewis, A., Zhu, W., Toubia, J., Pitman, M., Wallington-Beddoe, C., . . . Pitson, S. (2017). Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.. Blood, 129(6), 771-782.
Scopus24 WoS22 Europe PMC162017 Wallington-Beddoe, C., Bennett, M., Vandyke, K., Davies, L., Zebol, J., Moretti, P., . . . Pitson, S. (2017). Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress. Oncotarget, 8(27), 43602-43616.
Scopus12 WoS12 Europe PMC92017 Wallington-Beddoe, C., & Pitson, S. (2017). Enhancing ER stress in myeloma. Aging, 9(7), 1645-1646.
Scopus3 WoS3 Europe PMC22017 Wallington-Beddoe, C., & Pitson, S. (2017). Novel therapies for multiple myeloma. Aging, 9(8), 1857-1858.
Scopus1 WoS2 Europe PMC12017 Powell, J. A., Wallington-Beddoe, C. T., & Pitson, S. M. (2017). Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic.. International journal of hematologic oncology, 6(2), 31-34.
Europe PMC12014 Wallington-Beddoe, C., Powell, J., Tong, D., Pitson, S., Bradstock, K., & Bendall, L. (2014). Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Research, 74(10), 2803-2815.
Scopus40 WoS35 Europe PMC332013 Wallington-Beddoe, C., Bradstock, K., & Bendall, L. (2013). Oncogenic properties of sphingosine kinases in haematological malignancies. British Journal of Haematology, 161(5), 623-638.
Scopus10 WoS8 Europe PMC102012 Wallington-Beddoe, C., Don, A., Hewson, J., Qiao, Q., Papa, R., Lock, R., . . . Bendall, L. (2012). Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia. PLoS One, 7(5), e36429-1-e36429-7.
Scopus17 WoS14 Europe PMC112011 Wallington-Beddoe, C., Hewson, J., Bradstock, K., & Bendall, L. (2011). FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells. Autophagy, 7(7), 707-715.
Scopus59 WoS53 Europe PMC472009 Wallington-Beddoe, C., Gottlieb, D., Garvin, F., Antonenas, V., & Sartor, M. (2009). Failure to achieve a threshold bose of CD34+CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation for multiple myeloma. Biology of Blood and Marrow Transplantation, 15(11), 1386-1393.
Scopus12 WoS11 Europe PMC102003 Kumar, D., Wallington-Beddoe, C., George, J., Lin, R., Samarasinghe, D., Liddle, C., & Farrell, G. (2003). Effectiveness of interferon alfa-2b/ribavirin combination therapy for chronic hepatitis C in a clinic setting. Medical Journal of Australia, 178(6), 267-271.
Scopus18 WoS17 Europe PMC14 -
Conference Papers
Year Citation 2018 Bergin, K., Yuen, F., Wallington-Beddoe, C. T., Kalff, A., Sirdesai, S., Reynolds, J., & Spencer, A. (2018). Phase 2 Trial of the Combination of Ixazomib, Thalidomide and Dexamethasone (ITD) in Relapsed/Refractory Myeloma: Planned Preliminary Analysis. In BLOOD Vol. 132 (pp. 3 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2013 Wallington-Beddoe, C., Pitson, S., Bradstock, K., & Bendall, L. (2013). TARGETING SPHINGOSINE KINASE 2 SUPPRESSES MYC EXPRESSION AND KILLS ACUTE LYMPHOBLASTIC LEUKEMIA CELLS. In EXPERIMENTAL HEMATOLOGY Vol. 41 (pp. S49). Vienna, AUSTRIA: ELSEVIER SCIENCE INC.
2012 Wallington-Beddoe, C., Bradstock, K., & Bendall, L. (2012). SPHINGOSINE KINASES ARE IMPORTANT THERAPEUTIC TARGETS IN PRECURSOR B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA. In EXPERIMENTAL HEMATOLOGY Vol. 40 (pp. S81-S82). Amsterdam, NETHERLANDS: ELSEVIER SCIENCE INC. 2011 Wallington-Beddoe, C. T., Ho, D., Bradstock, K. F., & Bendall, L. J. (2011). Sphingosine Kinase Inhibition Has Pre-Clinical Activity in Acute Lymphoblastic Leukemia. In BLOOD Vol. 118 (pp. 1525). San Diego, CA: AMER SOC HEMATOLOGY. 2010 Wallington-Beddoe, C. T., Hewson, J., Bradstock, K. F., & Bendall, L. J. (2010). FTY720 Has Potent Anti-Leukemic Effects on Acute Lymphoblastic Leukemia Cells and Results In Caspase Independent Cell Death. In BLOOD Vol. 116 (pp. 1336-1337). Orlando, FL: AMER SOC HEMATOLOGY. 2010 Wallington-Beddoe, C. T., Bradstock, K., & Bendall, L. (2010). FTY720 IS AN EFFECTIVE THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA RESULTING IN CASPASE INDEPENDENT CELL DEATH. In EXPERIMENTAL HEMATOLOGY Vol. 38 (pp. S17). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2009 Antonenas, V., Wallington-Beddoe, C. T., Gottlieb, D., Garvin, F., & Sartor, M. (2009). FAILURE TO ACHIEVE A THRESHOLD DOSE OF CD34+CD110+PROGENITOR CELLS IN THE GRAFT PREDICTS DELAYED PLATELET ENGRAFTMENT AFTER AUTOLOGOUS STEM CELL TRANSPLANTATION FOR MULTIPLE MYELOMA. In EXPERIMENTAL HEMATOLOGY Vol. 37 (pp. S21). Athens, GREECE: ELSEVIER SCIENCE INC. -
Conference Items
Year Citation 2013 Wallington-Beddoe, C. T., Pitson, S. M., Powell, J. A., Bradstock, K. F., & Bendall, L. J. (2013). Evaluation Of Sphingosine Kinase 1 As a Therapeutic Target In B-Lineage Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. New Orleans, LA: AMER SOC HEMATOLOGY.
2012 Wallington-Beddoe, C. T., Bradstock, K. F., & Bendall, L. J. (2012). Identification of Sphingosine Kinases As Therapeutic Targets in B-Lineage Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
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