School of Physical Sciences
Faculty of Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Christopher Newton obtained his undergraduate degree from Victoria University of Wellington (New Zealand), and his PhD from the Australian National University under the supervision of Professor Michael Sherburn. Chris then moved to Lausanne, Switzerland to conduct a postdoctoral stay in the group of Professor Nicolai Cramer, before returning to Australia in 2018 to begin his independent academic career at the University of Adelaide.
The art and science of organic synthesis has reached a level where one can envision a synthetic route to almost any designed or natural molecule. Despite this spectacular achievement, the ability to access meaningful quantities of complex organic molecules is often impossible via current means. Traditionally, complex targets are synthesised from cheap, readily available feed-stocks, through lengthy sequences of chemical transformations. Each reaction requires expensive reagents, solvents, specialised equipment, and complex purification procedures, while also generating waste that has to be disposed of appropriately. Research in the Newton group is focused on directly addressing the problem of step-economy through the development of new reactions and strategies that enable the rapid generation of molecular complexity.
Year Citation 2019 Hart, J., Burchill, L., Day, A., Newton, C., Sumby, C., Huang, D., & George, J. (2019). Visible-light photoredox catalysis enables the biomimetic synthesis of nyingchinoids A, B, and D, and rasumatranin D. Angewandte Chemie International Edition, 58(9), 2791-2794.
2019 Horvath, K., Newton, C., Roper, K., Ward, J., & Sherburn, M. (2019). A broad-spectrum synthesis of tetravinylethylenes. Chemistry - A European Journal, 25(16), 4072-4076.
2018 Newton, C., Braconi, E., Kuziola, J., Wodrich, M., & Cramer, N. (2018). Axially chiral dibenzazepinones by a palladium(0)-catalyzed atropo-enantioselective C−H arylation. Angewandte Chemie - International Edition, 57(34), 11040-11044.
DOI Scopus24 WoS22 Europe PMC3
2017 Newton, C., Wang, S., Oliveira, C., & Cramer, N. (2017). Catalytic enantioselective transformations involving C-H bond cleavage by transition-metal complexes. Chemical Reviews, 117(13), 8908-8976.
DOI Scopus216 WoS211 Europe PMC54
2017 Newton, C. G., Tran, D. N., Wodrich, M. D., & Cramer, N. (2017). One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial B. Angewandte Chemie, 129(44), 13964-13968.
2017 Newton, C., Tran, D., Wodrich, M., & Cramer, N. (2017). One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial B. Angewandte Chemie - International Edition, 56(44), 13776-13780.
DOI Scopus17 WoS17 Europe PMC6
2016 Mackay, E., & Newton, C. (2016). Masked ketenes as dienophiles in the diels-alder reaction. Australian Journal of Chemistry, 69(12), 1365-1374.
DOI Scopus2 WoS2
2016 Newton, C., Kossler, D., & Cramer, N. (2016). Asymmetric Catalysis Powered by Chiral Cyclopentadienyl Ligands. Journal of the American Chemical Society, 138(12), 3935-3941.
DOI Scopus63 WoS61 Europe PMC28
2015 Newton, C., & Sherburn, M. (2015). Total synthesis of the pseudopterosin aglycones. Natural Product Reports, 32(6), 865-876.
DOI Scopus9 WoS7 Europe PMC3
2015 Newton, C., Drew, S., Lawrence, A., Willis, A., Paddon-Row, M., & Sherburn, M. (2015). Pseudopterosin synthesis from a chiral cross-conjugated hydrocarbon through a series of cycloadditions. Nature Chemistry, 7(1), 82-86.
DOI Scopus35 WoS32 Europe PMC14
2015 Mackay, E., Newton, C., Toombs-Ruane, H., Lindeboom, E., Fallon, T., Willis, A., . . . Sherburn, M. (2015). Radialene. Journal of the American Chemical Society, 137(46), 14653-14659.
DOI Scopus15 WoS13 Europe PMC2
2011 Cergol, K. M., Newton, C. G., Lawrence, A. L., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2011). 1,1-Divinylallene. Angewandte Chemie, 123(44), 10609-10612.
2011 Cergol, K., Newton, C., Lawrence, A., Willis, A., Paddon-Row, M., & Sherburn, M. (2011). 1,1-divinylallene. Angewandte Chemie - International Edition, 50(44), 10425-10428.
DOI Scopus24 WoS20 Europe PMC6
2010 Mulchin, B., Newton, C., Baty, J., Grasso, C., Martin, W., Walton, M., . . . Stocker, B. (2010). The anti-cancer, anti-inflammatory and tuberculostatic activities of a series of 6,7-substituted-5,8-quinolinequinones. Bioorganic and Medicinal Chemistry, 18(9), 3238-3251.
DOI Scopus42 WoS40 Europe PMC12
Year Citation 2019 Newton, C., & Cramer, N. (2019). Chiral Cp Ligands for Rhodium(III)‐Catalyzed Asymmetric Carbon–Hydrogen Bond Functionalization. In K. Tanaka (Ed.), Rhodium Catalysis in Organic Synthesis: Methods and Reactions (pp. 629-644). Germany: John Wiley & Sons.
2016 Newton, C., & Sherburn, M. (2016). Cross-conjugation in synthesis. In H. Hopf, & M. Sherburn (Eds.), Cross Conjugation: Dendralene, Radialene and Fulvene Chemistry (pp. 413-443). Germany: John Wiley & Sons.
Australian Research Council DECRA Fellowship
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor Enantioselective Hydroacylation for the Synthesis of Spirocycles Doctor of Philosophy Doctorate Full Time Mr Jacob David Hart 2019 Co-Supervisor Rapid Generation of Molecular Complexity via Diels-Alder Approaches Doctor of Philosophy Doctorate Full Time Mr Isuru Dissanayake 2018 Co-Supervisor Biomimetic Synthesis of Natural Products Doctor of Philosophy Doctorate Full Time Mr Aaron John Day
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