Associate Professor Christopher McDevitt
Membrane proteins account for about one-third of the proteins encoded by every genome but, in contrast to soluble proteins, they are poorly characterised. The research in my laboratory, based in the Research Centre for Infectious Diseases (RCID), investigates how the integral membrane protein ATP-binding cassette (ABC) transporters contribute to the virulence of the major human pathogens Streptococcus pneumoniae (responsible for >1 million deaths annually) and Staphylococcus aureus (a health care burden of >$1 billion AUS annually). My work has already made major advances in our understanding of how metal ion ABC transporters contribute to the virulence of these pathogens and the chemical biology of the host-pathogen interface. By understanding how these transporters function, our work is also providing the foundation for translating basic science into effective antimicrobial therapies. Notably, our research has already identified a molecular role for zinc in resisting bacterial infection, which is highly important as nearly 2 billion people are zinc deficient, and demonstrated the potential to exploit these ABC uptake transporters as antimicrobial targets due to their essential requirement for bacterial virulence, a complete lack of human homologs, and their highly exposed and accessible location on the bacterial cell-surface.
The long-term goal of my research is to target these metal ion transporters with next generation antimicrobials, which will save over 1 million lives annually. My research to achieve this goal is focused, first on elucidating how bacterial pathogens, e.g. S. pneumoniae, facilitate metal ion homeostasis, and second how we can target these mechanisms to attenuate virulence in the host environment. To this end we will continue to study the structure/function relationships of how these metal recruiting proteins work and then exploit our cutting edge knowledge, in which we are acknowledged world-leaders, to develop the next generation of antimicrobial therapeutic agents.
The projects in my laboratory (www.mcdevittlab.org) are focused on studying metal ion transporters of pathogenic bacteria. Bacterial infections are highly dependent on metal ion micronutrients. The high affinity metal ion uptake pathways are transporters called ATP-binding cassette (ABC) permeases. These transporters acquire metal ions from the extracellular host environment. Of particular interest to our group are the metal ions zinc and manganese, the second and third most abundant transition metal ions in living organisms. Manganese has essential roles during infection and colonization, where it serves in carbon metabolism and oxidative stress response. Zinc is a vital cofactor for numerous host and bacterial cellular functions. The manganese and zinc ABC uptake transporters have been shown to be essential for the virulence of a number of human pathogens including Streptococcus pneumoniae.
1. Manganese uptake in Streptococcus pneumoniae and other pathogens
Bacterial pathogens must scavenge their metal ions from the host environment in order to mediate virulence. Streptococcus pneumoniae is the world's foremost bacterial pathogen and is responsible for more than one million deaths every year. In terms of relative disease burden, it is the largest bacterial killer of young children and kills more children every year than AIDs, tuberculosis and malaria combined. However, its ability to infect and cause disease are dependent on the acquistion of metal ions, one of which is the transition row metal ion manganese. Loss of manganese uptake completely prevents its ability to cause disease.
Our group seeks to understand how S. pneumoniae, and other pathogens, scavenge manganese from the host environment. Although it was known an ABC importer was involved in this process, the underlying details were pooly understood. Recently we revealed the mechanism by which S. pneumoniae scavenges manganese from the host environment and how another metal ion, zinc, interfered with this process. We found that the manganese recruiting protein, PsaA, used a 'spring-hammer' mechanism to bind metal ions, in which half of the protein pivoted and closed over the other half.
There are still many unanswered questions that we are currently investigating. These include how is this ABC importer is selective for manganese ions, how are these ions are translocated into the bacterial cell, and how does the host prevent manganese from being scavenged by the bacteria during infection. Answering these questions will provide the necessary information to design the next generation of antimicrobial agents to target this essential bacterial pathway.
2. Zinc homeostasis in Streptococcus pneumoniae
Zinc is the second most abundant transition row element in biological systems. This metal ion has crucial roles in numerous cellular processes such as transcription, translation, catalysis and metabolism. As with all nutrients, pathogenic bacteria must scavenge zinc from the host in order to mediate disease.
Our studies have shown that manganese and zinc have an unusual relationship in S. pneumoniae, where zinc can actually block the manganese ABC importer. So we are seeking to understand how zinc is acquired and managed in this organism. Recently work from our lab identified that zinc uptake in S. pneumoniae, although similar to manganese uptake, was regulated in a more complex manner. Intriguingly zinc was recruited by 2 proteins, AdcA and AdcAII. A number of possible models have been proposed for how these proteins work together to recruit zinc.
Work in our group is focused on understanding how zinc is sensed by S. pneumoniae, how is zinc managed once it has been translocated into the cell, and how does the host utilise zinc during infection. The answers we obtain to these questions will lead to new ways to target this major human pathogen and its need for zinc.
Undergraduate: My laboratory has opportunities for enthusiastic undergraduate students who would like to improve their laboratory skills in an actual research environment. We currently offer placements for select undergraduates during the year who wish to undertake a small amount of research training (1 or 2 days a week) in preparation for Honours. For more information about opportunities please contact me.
Honours: My laboratory has 4 multidisciplinary Honours projects on offer in 2017 that combine genetics and biochemistry to study the virulence mechanisms of major bacterial pathogens. A project in my lab will provide you with a strong set of research skills ideally suited for a job in science or further PhD research. Please see my webpage for further details.
|2017||ARC Future Fellow||University of Adelaide, Adelaide|
|2017||Associate Professor||University of Adelaide|
|2016||Deputy Director, Australian Centre for Antimicrobial Resistance Ecology||Universiy of Adelaide|
|2014||Deputy Director, Research Centre for Infectious Diseases||University of Adelaide|
|2008||NHMRC Research Fellow||University of Adelaide|
|2005 - 2008||Senior Research Associate||University of Oxford|
|2002 - 2005||Research Associate||University of Oxford|
|2011||Award||RCDN Mid-Career Research Award||The University of Adelaide|
|2007 - 2008||Fellowship||EPA Cephalosporin Junior Research Fellow||Linacre College, University of Oxford|
|University of Queensland||Australia||BSc (Hons)|
|University of Queensland||Australia||PhD|
|2017||Trappetti, C., McAllister, L., Chen, A., Wang, H., Paton, A., Oggioni, M. ... Paton, J. (2017). Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by streptococcus pneumoniae, resulting in hypervirulence. L. McDaniel (Ed.). mBio, 8, 1, e02269-16-1-e02269-16-18.
|2017||Hassan, K., Pederick, V., Elbourne, L., Paulsen, I., Paton, J., McDevitt, C. & Eijkelkamp, B. (2017). Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology, 17, 1, 59-1-59-15.
|2017||Martin, J., Edmonds, K., Bruce, K., Campanello, G., Eijkelkamp, B., Brazel, E. ... Giedroc, D. (2017). The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity. Molecular Microbiology, 104, 4, 636-651.
|2017||Eyre, N., Johnson, S., Eltahla, A., Aloi, M., Aloia, A., McDevitt, C. ... Beard, M. (2017). Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses. Journal of virology, 91, 23, 1-25.
|2017||Grim, K., San Francisco, B., Radin, J., Brazel, E., Kelliher, J., Párraga Solórzano, P. ... Kehl-Fie, T. (2017). The metallophore staphylopine enables Staphylococcus aureus to compete with the host for zinc and overcome nutritional immunity. V. Torres (Ed.). mBio, 8, 5, 1-16.
|2016||Heng, S., McDevitt, C., Kostecki, R., Morey, J., Eijkelkamp, B., Ebendorff-Heidepriem, H. ... Abell, A. (2016). Microstructured optical fiber-based biosensors: reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces, 8, 20, 12727-12732.
|2015||Bajaj, M., Mamidyala, S., Zuegg, J., Begg, S., Ween, M., Luo, Z. ... Cooper, M. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10, 6, 1511-1520.
|2015||Pederick, V., Eijkelkamp, B., Begg, S., Ween, M., McAllister, L., Paton, J. & McDevitt, C. (2015). ZnuA and zinc homeostasis in pseudomonas aeruginosa. Scientific Reports, 5, 1, 13139-1-13139-14.
|2015||Luo, Z., Morey, J., McDevitt, C. & Kobe, B. (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica Section F: Structural Biology Communications, 71, Pt 12, 1459-1464.
|2015||Deplazes, E., Begg, S., van Wonderen, J., Campbell, R., Kobe, B., Paton, J. ... O'Mara, M. (2015). Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60.
|2015||Begg, S. L., Eijkelkamp, B. A., Luo, Z., Couñago, R. M., Morey, J. R., Maher, M. J. ... McDevitt, C. A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6, 6418, 6418-1-6418-11.
|2015||Eijkelkamp, B. A., McDevitt, C. A. & Kitten, T. (2015). Manganese uptake and streptococcal virulence. Biometals, 28, 3, 491-508.
|2015||Morey, J., McDevitt, C. & Kehl-Fie, T. (2015). Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28, 3, 509-519.
|2015||Eijkelkamp, B., Pederick, V., Plumptre, C., Harvey, R., Hughes, C., Paton, J. & McDevitt, C. (2015). The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. A. Camilli (Ed.). Infection and Immunity, 84, 2, 407-415.
|2014||Plumptre, C., Eijkelkamp, B., Morey, J., Behr, F., Couñago, R., Ogunniyi, A. ... McDevitt, C. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91, 4, 834-851.
|2014||Van Wonderen, J., McMahon, R., OMara, M., McDevitt, C., Thomson, A., Kerr, I. ... Callaghan, R. (2014). The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal, 281, 9, 2190-2201.
|2014||Counago, R., Ween, M., Begg, S., Bajaj, M., Zuegg, J., O'Mara, M. ... McDevitt, C. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10, 1, 35-43.
|2014||Pederick, V., Eijkelkamp, B., Ween, M., Begg, S., Paton, J. & McDevitt, C. (2014). Acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80, 21, 6843-6852.
|2014||Eijkelkamp, B., Morey, J., Ween, M., Ong, C., McEwan, A., Paton, J. & McDevitt, C. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One, 9, 2, e89427-1-e89427-11.
|2014||Pollock, N., McDevitt, C., Collins, R., Niesten, P., Prince, S., Kerr, I. ... Callaghan, R. (2014). Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochimica et Biophysica Acta-Biomembranes, 1838, 1, 134-147.
|2014||Plumptre, C. D., Hughes, C. E., Harvey, R. M., Eijkelkamp, B. A., McDevitt, C. A. & Paton, J. C. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity, 82, 10, 4315-4324.
|2013||Heng, S., McDevitt, C., Stubing, D., Whittall, J., Thompson, J., Engler, T. ... Monro, T. (2013). Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules, 14, 10, 3376-3379.
|2012||Counago, R., McDevitt, C., Ween, M. & Kobe, B. (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13, 11, 1400-1410.
|2012||Pederick, V., Ween, M. & McDevitt, C. (2012). The role of ATP-binding cassette transporters in bacterial pathogenicity. Protoplasma, 249, 4, 919-942.
|2012||Lehane, A., McDevitt, C., Kirk, K. & Fidock, D. (2012). Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?. International Journal for Parasitology: Drugs and Drug Resistance, 2, 47-57.
|2011||McDevitt, C., Ogunniyi, A., Valkov, E., Lawrence, M., Kobe, B., McEwan, A. & Paton, J. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7, 11, 2357-2365.
|2010||Ogunniyi, A., Mahdi, L., Jennings, M., McEwan, A., McDevitt, C., Van der Hoek, M. ... Paton, J. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192, 17, 4489-4497.
|2009||McDevitt, C., Collins, R., Kerr, I. & Callaghan, R. (2009). Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews, 61, 1, 57-65.
|2008||McDevitt, C., Crowley, E., Hobbs, G., Starr, K., Kerr, I. & Callaghan, R. (2008). Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?. FEBS Journal, 275, 17, 4354-4362.
|2008||McDevitt, C., Shintre, C., Grossmann, G., Pollock, N., Prince, S., Callaghan, R. & Ford, R. (2008). Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.. FEBS Letters, 582, 19, 2950-2956.
|2007||McDevitt, C. & Callaghan, R. (2007). How can we best use structural information on P-glycoprotein to design inhibitors?. Pharmacology & Therapeutics, 113, 2, 429-441.
|2006||McDevitt, C., Collins, R., Conway, M., Modok, S., Storm, J., Kerr, I. ... Callaghan, R. (2006). Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure, 14, 11, 1623-1632.
|2006||McDevitt, C., Sargent, F., Palmer, T., Berks, B. & Buchanan, G. (2006). Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal, 273, 24, 5656-5668.
|2005||McDevitt, C., Hicks, M., Palmer, T. & Berks, B. (2005). Characterisation of Tat protein transport complexes carrying inactivating mutations. Biochemical and Biophysical Research Communications, 329, 2, 693-698.
|2005||Gohlke, U., Pullan, L., McDevitt, C., Porcelli, I., de Leeuw, E., Palmer, T. ... Berks, B. (2005). The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proceedings of the National Academy of Sciences of the United States of America, 102, 30, 10482-10486.
|2002||McDevitt, C., Hugenholtz, P., Hanson, G. & McEwan, A. (2002). Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: Its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology, 44, 6, 1575-1587.
|2002||McDevitt, C., Hanson, G., Noble, C., Cheesman, M. & McEwan, A. (2002). Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum. Biochemistry, 41, 51, 15234-15244.
|2002||McEwan, A., Ridge, J., McDevitt, C. & Hugenholtz, P. (2002). The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal, 19, 1, 3-21.
|2001||Hanson, G., McDevitt, C. & McEwan, A. (2001). Dimethylsulfide dehydrogenase from rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes. JOURNAL OF INORGANIC BIOCHEMISTRY, 86, 1, 248-248.|
|2000||McDevitt, C., Burrell, P., Blackall, L. & McEwan, A. (2000). Aerobic nitrate respiration in a nitrite-oxidising bioreactor. FEMS Microbiology Letters, 184, 1, 113-118.
|2016||McDevitt, C., Begg, S. & Paton, J. (2016). Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae. In F. de Burjin (Ed.), Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (pp. 1184-1193). Hoboken, NJ, USA: John Wiley & Sons, Inc..
|2010||Crowley, E., McDevitt, C. & Callaghan, R. (2010). Generating inhibitors of P-glycoprotein: where to, now?. In J. Zhou (Ed.), Multi-drug resistance in cancer (pp. 405-432). United States of America: Humana Press.
|2004||McEwan, A., Kappler, U. & McDevitt, C. (2004). Microbial molybdenum-containing enzymes in respiration: Structural and functional aspects. In Davide Zannoni (Ed.), Respiration in Archaea and Bacteria: Diversity of Prokaryotic Respiratory Systems (pp. 175-202). The Netherlands: Kluwer Academic Publishers.|
|2004||Mcewan, A., Bernhardt, P., Creevey, N., Hanson, G. & McDevitt, C. (2004). Ion motive electron transfer pathways involving type II molybdoenzymes of the DMSO reductase family. 13th European Bioenergetics Conference (EBEC 2004). Pisa, ITALY.|
|2003||Hanson, G., Noble, C., McDevitt, C. & McEwan, A. (2003). CW and pulsed EPR spectroscopy reveal a new structural motif for the active site Mo centre and an unusual [4Fe-4S](+) cluster in dimethylsulfide dehydrogenase.. 11th International Conference on Biological Inorganic Chemistry. CAIMS, AUSTRALIA.
|2016||Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R. ... McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. BioMetals 2016. Dresden, Germany.|
|2015||Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C. & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. An exchange workshop on antimicrobial resistance. UniSA.|
|2015||Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V. ... Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015. Queensland, AUSTRALIA.|
|2015||Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C. & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC.|
|2013||Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C. & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. School of Molecular and Biomedical Sciences 3-Minute Thesis competition.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology BD Student Award.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. ASBMB ComBio.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. School of Molecular and Biomedical Sciences Postgraduate Symposium.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology Scientific Meeting.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. ABC2012 – 4th FEBS Special Meeting on ABC Proteins.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. Faculty of Sciences 3-Minute Thesis competition.|
|2012||Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. Adelaide Protein Group.|
|2011||Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. School of Molecular and Biomedical Science Research Symposium.|
|2011||Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Adelaide Protein Group.|
|2011||Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Australian Society for Medical Research SA Meeting.|
|Sumby, C., McDevitt, C., Begg, S. & Young, R. (). Silver Coordination Polymers: Relationships between structure and antibacterial activity.
Our research is supported by:
National Health and Medical Research Council (NHMRC)
- Project Grant (CIA) - APP1140554 (2018–20) $843,035
- Project Grant (CIB) - APP1145075 (2018–21) $784,541
- Doherty Early Career Fellowship - Dr Stephanie Begg (2018-2021) $322,952
- Project Grant (CIA) - APP1122582 (2017-2019) $870,924
- Project Grant (CIB) - APP1080784 (2015-2017) $613,134
- Project Grant (CIA) - APP1022240 (2012-2014) $568,375
- Equipment Grant (CIA) - Liquid handling platform (2015) $20,870
- Equipment Grant (CIA) - qRT-PCR equipment (2014) $40,000
- Equipment Grant (CIA) - Spectrophotometric equipment - (2012) $35,500
- Equipment Grant (CIA) - Refrigerated AKTA FPLC - (2011) $62,042
- Equipment Grant (CIA) - Beckman Coulter Optima Max Biosafe Ultracentrifugation System - (2010) $78,000
- Equipment Grant (CID) - Cell disruptor system - (2009) $22,000
- Equipment Grant (CII) - Replacement Purification Systems - (2008) $28,401
Australian Research Council (ARC)
- Future Fellowship - FT170100006 (2017-2021) $879,617
- Discovery Project (CIA) - DP170102102 (2017-2019) $605,500
- Discovery Project (CIB) - DP150104515 (2015-2017) $384,300
- Discovery Project (CIA) - DP120103957 (2012-2014) $255,000
Channel 7 Children's Research Foundation
- Project - Dr Bart Eijkelkamp (CIA) and Christopher McDevitt (CIB) - (2016) $35,000
- Project - Ms Victoria Lewis (CIA) and Christopher McDevitt (CIB) - (2013) $31,000
- Project (CIA) - (2010-2011) $98,000
Australian Cystic Fibrosis Foundation
- Postgraduate Studentship Grant - (2011-2013) $15,000
Clive and Vera Ramaciotti Foundation
- Equipment Grant (Coordinator) - Zetasizer Nano ZSP for protein characterisation and drug discovery - (2013) $54,783
- Equipment Grant (Coordinator) - Instrumentation for cellular and subcellular analyses - (2012) $67,595
University of Adelaide
- DVCR IRF Grant (CIE) Accelerating biological discovery through Artificial Intelligence - (2017) $90,000
- DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (Bioruptor) - (2015) $50,000
- DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (HPLC) - (2015) $28,000
- IPAS Extending Collaborations Pilot Projects (CIB) - (2014) $16,000
- IPAS Extending Collaborations Pilot Projects (CIB) - (2013) $8,500
- DVCR Equipment Grant (CIA) - Temperature controlled shaking incubators - (2012) $81,136
- DVCR Equipment Grant (CIA) - High speed centrifugation infrastructure - (2012) $365,813
- Biomed IIA
- Principles and Practice of Research (Advanced) II
- Principles and Practice of Research (Advanced) III
- Infection and Immunity IIA
- Principal supervisor – Erin Brazel
- Principal supervisor – Saleh Aqualthamy
- Co-Supervisor – Harley Betts
- Principal supervisor – Dr Jacqueline Morey (University of Adelaide; completed 2017)
- Dean’s Commendation for Doctoral Thesis Excellence (2017); BacPath13 Poster Prize (2015); Adelaide Protein Group Annual Student Award Event Poster Prize (2015); 1 invited oral presentation at an international conference (Biometals, Germany, 2016); 1 invited oral presentation at a national conference (BacPath14, 2017).
- Principal supervisor – Dr Stephanie Begg (University of Adelaide; completed 2016)
- NHMRC Early Career Fellowship (2018-21) $322,952; ASBMB Travelling Fellowship (2017); University of Adelaide Doctoral Medal for Research Excellence (2017); Dean’s Commendation for Doctoral Thesis Excellence (2017); BacPath14 Poster Prize (2017); The Australian Federation of Graduate Women Barbara Hale Fellowship (2015) $8,000; Adelaide Protein Group Annual Student Award Event Oral Prize (2015); 5th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins Best Poster Prize (2014, Innsbruck, Austria); 1 invited oral presentation at a national conference (BacPath13, 2015).
- Principal supervisor – Dr Victoria Pederick (University of Adelaide; completed 2015)
- Channel 7 Children’s Research Foundation ECR Grant (2013) $31,000; Australian Cystic Fibrosis Foundation Postgraduate Studentship Grant (2011-2013) $15,000; The Australian Society for Microbiology Annual Scientific Meeting Poster Prize (2013); Best oral presentation – Annual Postgraduate Symposium, School of Molecular and Biomedical Science (2012); Adelaide Protein Group Student Award Event Best Poster (2012); 1 invited oral presentation at an international conference (Biometals, Germany, 2016).
- Co-supervisor – Zhenyao Luo (University of Queensland; completed 2015)
- Principal supervisor – Marina Zupan (First Class, 2017)
- Principal supervisor – Kimberley McLean (First Class, 2017)
- Principal supervisor – Erin Brazel (First Class, 2015; Derrick Rowley Microbiology & Immunology Prize Winner)
- Principal supervisor – Amy Burns (First Class, 2015)
- Principal supervisor – Jacqueline Morey (First Class, 2012)
- Principal supervisor – Jonathan Whittall (First Class, 2012)
- Principal supervisor – Victoria Lewis (First Class, 2010)
|2010 - ongoing||Australian Biophysical Society|
|2008 - ongoing||Australian Society of Biochemistry and Molecular Biology|
|2004 - ongoing||Representative||UK Biochemical Society||United Kingdom|
|2015 - ongoing||President||Adelaide Protein Group|
|2015 - ongoing||Member||School of Biological Sciences Research Committee||University of Adelaide||Australia|
|2015 - ongoing||Member||School of Biological Sciences Health, Safety & Wellbeing Committee||University of Adelaide|
|2013 - ongoing||Representative||EU COST Action Group - Molecular Machineries for Ion Translocation Across Biomembranes|
|2012 - 2015||Treasurer||Adelaide Protein Group|
|Date||Role||Editorial Board Name||Country|
|2016 - ongoing||Member||Frontiers in Microbiology|
|2016 - ongoing||Associate Editor||Scientific Reports|
|2014 - ongoing||Editor||Frontiers in cellular and infection microbiology|