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Associate Professor Christopher McDevitt

Christopher McDevitt
ARC Future Fellow
School of Biological Sciences
Faculty of Sciences

Membrane proteins account for about one-third of the proteins encoded by every genome but, in contrast to soluble proteins, they are poorly characterised. The research in my laboratory, based in the Research Centre for Infectious Diseases (RCID), investigates how the integral membrane protein ATP-binding cassette (ABC) transporters contribute to the virulence of the major human pathogens Streptococcus pneumoniae (responsible for >1 million deaths annually) and Staphylococcus aureus (a health care burden of >$1 billion AUS annually). My work has already made major advances in our understanding of how metal ion ABC transporters contribute to the virulence of these pathogens and the chemical biology of the host-pathogen interface. By understanding how these transporters function, our work is also providing the foundation for translating basic science into effective antimicrobial therapies. Notably, our research has already identified a molecular role for zinc in resisting bacterial infection, which is highly important as nearly 2 billion people are zinc deficient, and demonstrated the potential to exploit these ABC uptake transporters as antimicrobial targets due to their essential requirement for bacterial virulence, a complete lack of human homologs, and their highly exposed and accessible location on the bacterial cell-surface.

The long-term goal of my research is to target these metal ion transporters with next generation antimicrobials, which will save over 1 million lives annually. My research to achieve this goal is focused, first on elucidating how bacterial pathogens, e.g. S. pneumoniae, facilitate metal ion homeostasis, and second how we can target these mechanisms to attenuate virulence in the host environment. To this end we will continue to study the structure/function relationships of how these metal recruiting proteins work and then exploit our cutting edge knowledge, in which we are acknowledged world-leaders, to develop the next generation of antimicrobial therapeutic agents.

Associate Professor Christopher McDevitt

Membrane proteins account for about one-third of the proteins encoded by every genome but, in contrast to soluble proteins, they are poorly characterised. The research in my laboratory, based in the Research Centre for Infectious Diseases (RCID), investigates how the integral membrane protein ATP-binding cassette (ABC) transporters contribute to the virulence of the major human pathogens Streptococcus pneumoniae (responsible for >1 million deaths annually) and Staphylococcus aureus (a health care burden of >$1 billion AUS annually). My work has already made major advances in our understanding of how metal ion ABC transporters contribute to the virulence of these pathogens and the chemical biology of the host-pathogen interface. By understanding how these transporters function, our work is also providing the foundation for translating basic science into effective antimicrobial therapies. Notably, our research has already identified a molecular role for zinc in resisting bacterial infection, which is highly important as nearly 2 billion people are zinc deficient, and demonstrated the potential to exploit these ABC uptake transporters as antimicrobial targets due to their essential requirement for bacterial virulence, a complete lack of human homologs, and their highly exposed and accessible location on the bacterial cell-surface.

The long-term goal of my research is to target these metal ion transporters with next generation antimicrobials, which will save over 1 million lives annually. My research to achieve this goal is focused, first on elucidating how bacterial pathogens, e.g. S. pneumoniae, facilitate metal ion homeostasis, and second how we can target these mechanisms to attenuate virulence in the host environment. To this end we will continue to study the structure/function relationships of how these metal recruiting proteins work and then exploit our cutting edge knowledge, in which we are acknowledged world-leaders, to develop the next generation of antimicrobial therapeutic agents.

Eligible to supervise Masters and PhD — email supervisor to discuss availability.

The projects in my laboratory (www.mcdevittlab.org) are focused on studying metal ion transporters of pathogenic bacteria. Bacterial infections are highly dependent on metal ion micronutrients. The high affinity metal ion uptake pathways are transporters called ATP-binding cassette (ABC) permeases. These transporters acquire metal ions from the extracellular host environment. Of particular interest to our group are the metal ions zinc and manganese, the second and third most abundant transition metal ions in living organisms. Manganese has essential roles during infection and colonization, where it serves in carbon metabolism and oxidative stress response. Zinc is a vital cofactor for numerous host and bacterial cellular functions. The manganese and zinc ABC uptake transporters have been shown to be essential for the virulence of a number of human pathogens including Streptococcus pneumoniae.

1. Manganese uptake in Streptococcus pneumoniae and other pathogens

Bacterial pathogens must scavenge their metal ions from the host environment in order to mediate virulence. Streptococcus pneumoniae is the world's foremost bacterial pathogen and is responsible for more than one million deaths every year. In terms of relative disease burden, it is the largest bacterial killer of young children and kills more children every year than AIDs, tuberculosis and malaria combined. However, its ability to infect and cause disease are dependent on the acquistion of metal ions, one of which is the transition row metal ion manganese. Loss of manganese uptake completely prevents its ability to cause disease.

PsaA transition to closed state
Apo-PsaA transition to closed metal-bound conformation.

Our group seeks to understand how S. pneumoniae, and other pathogens, scavenge manganese from the host environment. Although it was known an ABC importer was involved in this process, the underlying details were pooly understood. Recently we revealed the mechanism by which S. pneumoniae scavenges manganese from the host environment and how another metal ion, zinc, interfered with this process. We found that the manganese recruiting protein, PsaA, used a 'spring-hammer' mechanism to bind metal ions, in which half of the protein pivoted and closed over the other half.

There are still many unanswered questions that we are currently investigating. These include how is this ABC importer is selective for manganese ions, how are these ions are translocated into the bacterial cell, and how does the host prevent manganese from being scavenged by the bacteria during infection. Answering these questions will provide the necessary information to design the next generation of antimicrobial agents to target this essential bacterial pathway.

2. Zinc homeostasis in Streptococcus pneumoniae

Zn homeostasis mechanisms of S. pneumoniae
Zn homeostasis mechanisms of S. pneumoniae

Zinc is the second most abundant transition row element in biological systems. This metal ion has crucial roles in numerous cellular processes such as transcription, translation, catalysis and metabolism. As with all nutrients, pathogenic bacteria must scavenge zinc from the host in order to mediate disease.

Our studies have shown that manganese and zinc have an unusual relationship in S. pneumoniae, where zinc can actually block the manganese ABC importer. So we are seeking to  understand how zinc is acquired and managed in this organism. Recently work from our lab identified that zinc uptake in S. pneumoniae, although similar to manganese uptake, was regulated in a more complex manner. Intriguingly zinc was recruited by 2  proteins, AdcA and AdcAII. A number of possible models have been proposed for how these proteins work together to recruit zinc.

Work in our group is focused on understanding how zinc is sensed by S. pneumoniae, how is zinc managed once it has been translocated into the cell, and how does the host utilise zinc during infection. The answers we obtain to these questions will lead to new ways to target this major human pathogen and its need for zinc.

Research Opportunities

Undergraduate: My laboratory has opportunities for enthusiastic undergraduate students who would like to improve their laboratory skills in an actual research environment.  We currently offer placements for select undergraduates during the year who wish to undertake a small amount of research training (1 or 2 days a week) in preparation for Honours. For more information about opportunities please contact me.

Honours: My laboratory has 4 multidisciplinary Honours projects on offer in 2017 that combine genetics and biochemistry to study the virulence mechanisms of major bacterial pathogens. A project in my lab will provide you with a strong set of research skills ideally suited for a job in science or further PhD research. Please see my webpage for further details.

Appointments

Date Position Institution name
2017 ARC Future Fellow University of Adelaide, Adelaide
2017 Associate Professor University of Adelaide
2016 Deputy Director, Australian Centre for Antimicrobial Resistance Ecology Universiy of Adelaide
2014 Deputy Director, Research Centre for Infectious Diseases University of Adelaide
2008 NHMRC Research Fellow University of Adelaide
2005 - 2008 Senior Research Associate University of Oxford
2002 - 2005 Research Associate University of Oxford

Awards and Achievements

Date Type Title Institution Name Country Amount
2011 Award RCDN Mid-Career Research Award The University of Adelaide Australia
2007 Fellowship EPA Cephalosporin Junior Research Fellow Linacre College, University of Oxford United Kingdom

Education

Date Institution name Country Title
University of Queensland Australia PhD
University of Queensland Australia BSc (Hons)

Research Interests

Journals

Year Citation
2018 Ryan, T., Trewhella, J., Murphy, J., Keown, J., Casey, L., Pearce, F., . . . Kirby, N. (2018). An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography, 51(1), 97-111.
DOI
2018 Satiaputra, J., Eijkelkamp, B., McDevitt, C., Shearwin, K., Booker, G., & Polyak, S. (2018). Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin. Applied Microbiology and Biotechnology, 102(8), 3793-3803.
DOI
2018 Eijkelkamp, B., Begg, S., Pederick, V., Trapetti, C., Gregory, M., Whittall, J., . . . McDevitt, C. (2018). Arachidonic acid stress impacts pneumococcal fatty acid homeostasis. Frontiers in Microbiology, 9(MAY), 813-1-813-12.
DOI
2018 Luo, Z., Pederick, V. G., Paton, J. C., McDevitt, C. A., & Kobe, B. (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.. FEBS letters.
DOI
2017 Eyre, N., Johnson, S., Eltahla, A., Aloi, M., Aloia, A., McDevitt, C., . . . Beard, M. (2017). Genome-wide mutagenesis of dengue virus reveals plasticity of the NS1 protein and enables generation of infectious tagged reporter viruses. Journal of Virology, 91(23), e01455-17-1-e01455-17-25.
DOI Scopus3 WoS3 Europe PMC3
2017 Grim, K., San Francisco, B., Radin, J., Brazel, E., Kelliher, J., Párraga Solórzano, P., . . . Kehl-Fie, T. (2017). The metallophore staphylopine enables Staphylococcus aureus to compete with the host for zinc and overcome nutritional immunity. mBio, 8(5), 1-16.
DOI Scopus4 WoS3 Europe PMC4
2017 Trappetti, C., McAllister, L., Chen, A., Wang, H., Paton, A., Oggioni, M., . . . Paton, J. (2017). Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by streptococcus pneumoniae, resulting in hypervirulence. mBio, 8(1), e02269-16-1-e02269-16-18.
DOI Scopus7 WoS8 Europe PMC4
2017 Martin, J., Edmonds, K., Bruce, K., Campanello, G., Eijkelkamp, B., Brazel, E., . . . Giedroc, D. (2017). The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity. Molecular Microbiology, 104(4), 636-651.
DOI Scopus6 WoS4 Europe PMC5
2017 Hassan, K., Pederick, V., Elbourne, L., Paulsen, I., Paton, J., McDevitt, C., & Eijkelkamp, B. (2017). Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology, 17(1), 59-1-59-15.
DOI Scopus3 WoS2 Europe PMC2
2016 Heng, S., McDevitt, C., Kostecki, R., Morey, J., Eijkelkamp, B., Ebendorff-Heidepriem, H., . . . Abell, A. (2016). Microstructured optical fiber-based biosensors: reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces, 8(20), 12727-12732.
DOI Scopus8 WoS8 Europe PMC3
2015 Pederick, V., Eijkelkamp, B., Begg, S., Ween, M., McAllister, L., Paton, J., & McDevitt, C. (2015). ZnuA and zinc homeostasis in pseudomonas aeruginosa. Scientific Reports, 5(1), 13139-1-13139-14.
DOI Scopus19 WoS18 Europe PMC16
2015 Deplazes, E., Begg, S., van Wonderen, J., Campbell, R., Kobe, B., Paton, J., . . . O'Mara, M. (2015). Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60.
DOI Scopus3 WoS3 Europe PMC1
2015 Eijkelkamp, B., Pederick, V., Plumptre, C., Harvey, R., Hughes, C., Paton, J., & McDevitt, C. (2015). The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. Infection and Immunity, 84(2), 407-415.
DOI Scopus7 WoS7 Europe PMC5
2015 Luo, Z., Morey, J., McDevitt, C., & Kobe, B. (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica Section F: Structural Biology Communications, 71(Pt 12), 1459-1464.
DOI WoS1
2015 Eijkelkamp, B., McDevitt, C., & Kitten, T. (2015). Manganese uptake and streptococcal virulence. Biometals, 28(3), 491-508.
DOI Scopus15 WoS14 Europe PMC8
2015 Begg, S., Eijkelkamp, B., Luo, Z., Couñago, R., Morey, J., Maher, M., . . . McDevitt, C. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6(6418), 6418-1-6418-11.
DOI Scopus33 WoS31 Europe PMC20
2015 Bajaj, M., Mamidyala, S., Zuegg, J., Begg, S., Ween, M., Luo, Z., . . . Cooper, M. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10(6), 1511-1520.
DOI Scopus8 WoS6 Europe PMC3
2015 Morey, J., McDevitt, C., & Kehl-Fie, T. (2015). Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(3), 509-519.
DOI Scopus6 WoS6 Europe PMC5
2014 Pederick, V., Eijkelkamp, B., Ween, M., Begg, S., Paton, J., & McDevitt, C. (2014). Acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80(21), 6843-6852.
DOI Scopus13 WoS11 Europe PMC11
2014 Plumptre, C., Eijkelkamp, B., Morey, J., Behr, F., Couñago, R., Ogunniyi, A., . . . McDevitt, C. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91(4), 834-851.
DOI Scopus34 WoS33 Europe PMC27
2014 Plumptre, C., Hughes, C., Harvey, R., Eijkelkamp, B., McDevitt, C., & Paton, J. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity, 82(10), 4315-4324.
DOI Scopus12 WoS10 Europe PMC9
2014 Van Wonderen, J., McMahon, R., OMara, M., McDevitt, C., Thomson, A., Kerr, I., . . . Callaghan, R. (2014). The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal, 281(9), 2190-2201.
DOI Scopus23 WoS20 Europe PMC8
2014 Eijkelkamp, B., Morey, J., Ween, M., Ong, C., McEwan, A., Paton, J., & McDevitt, C. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One, 9(2), e89427-1-e89427-11.
DOI Scopus41 WoS39 Europe PMC30
2014 Pollock, N., McDevitt, C., Collins, R., Niesten, P., Prince, S., Kerr, I., . . . Callaghan, R. (2014). Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochimica et Biophysica Acta-Biomembranes, 1838(1), 134-147.
DOI Scopus13 WoS11 Europe PMC7
2014 Counago, R., Ween, M., Begg, S., Bajaj, M., Zuegg, J., O'Mara, M., . . . McDevitt, C. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10(1), 35-43.
DOI Scopus51 WoS47 Europe PMC32
2013 Heng, S., McDevitt, C., Stubing, D., Whittall, J., Thompson, J., Engler, T., . . . Monro, T. (2013). Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules, 14(10), 3376-3379.
DOI Scopus18 WoS16 Europe PMC3
2012 Pederick, V., Ween, M., & McDevitt, C. (2012). The role of ATP-binding cassette transporters in bacterial pathogenicity. Protoplasma, 249(4), 919-942.
DOI Scopus39 WoS35 Europe PMC29
2012 Counago, R., McDevitt, C., Ween, M., & Kobe, B. (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13(11), 1400-1410.
DOI Scopus25 WoS24 Europe PMC11
2012 Lehane, A., McDevitt, C., Kirk, K., & Fidock, D. (2012). Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?. International Journal for Parasitology: Drugs and Drug Resistance, 2, 47-57.
DOI Scopus22 WoS19 Europe PMC16
2011 McDevitt, C., Ogunniyi, A., Valkov, E., Lawrence, M., Kobe, B., McEwan, A., & Paton, J. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7(11), 2357-2365.
DOI Scopus146 WoS139 Europe PMC115
2010 Ogunniyi, A., Mahdi, L., Jennings, M., McEwan, A., McDevitt, C., Van der Hoek, M., . . . Paton, J. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192(17), 4489-4497.
DOI Scopus50 WoS50 Europe PMC41
2009 McDevitt, C., Collins, R., Kerr, I., & Callaghan, R. (2009). Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews, 61(1), 57-65.
DOI WoS18 Europe PMC14
2008 McDevitt, C., Shintre, C., Grossmann, G., Pollock, N., Prince, S., Callaghan, R., & Ford, R. (2008). Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.. FEBS Letters, 582(19), 2950-2956.
DOI Scopus15 WoS16 Europe PMC12
2008 McDevitt, C., Crowley, E., Hobbs, G., Starr, K., Kerr, I., & Callaghan, R. (2008). Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?. FEBS Journal, 275(17), 4354-4362.
DOI Scopus23 WoS23 Europe PMC18
2007 McDevitt, C., & Callaghan, R. (2007). How can we best use structural information on P-glycoprotein to design inhibitors?. Pharmacology & Therapeutics, 113(2), 429-441.
DOI WoS96 Europe PMC52
2006 McDevitt, C., Collins, R., Conway, M., Modok, S., Storm, J., Kerr, I., . . . Callaghan, R. (2006). Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure, 14(11), 1623-1632.
DOI WoS86 Europe PMC55
2006 McDevitt, C., Sargent, F., Palmer, T., Berks, B., & Buchanan, G. (2006). Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal, 273(24), 5656-5668.
DOI Scopus42 WoS39 Europe PMC33
2005 Gohlke, U., Pullan, L., McDevitt, C., Porcelli, I., de Leeuw, E., Palmer, T., . . . Berks, B. (2005). The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10482-10486.
DOI Scopus186 WoS188 Europe PMC125
2005 McDevitt, C., Hicks, M., Palmer, T., & Berks, B. (2005). Characterisation of Tat protein transport complexes carrying inactivating mutations. Biochemical and Biophysical Research Communications, 329(2), 693-698.
DOI Scopus29 WoS30 Europe PMC22
2002 McDevitt, C., Hugenholtz, P., Hanson, G., & McEwan, A. (2002). Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: Its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology, 44(6), 1575-1587.
DOI Scopus93 WoS89 Europe PMC45
2002 McDevitt, C., Hanson, G., Noble, C., Cheesman, M., & McEwan, A. (2002). Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum. Biochemistry, 41(51), 15234-15244.
DOI Scopus31 WoS28 Europe PMC20
2002 McEwan, A., Ridge, J., McDevitt, C., & Hugenholtz, P. (2002). The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal, 19(1), 3-21.
DOI Scopus71 WoS58
2001 Hanson, G., McDevitt, C., & McEwan, A. (2001). Dimethylsulfide dehydrogenase from rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes. JOURNAL OF INORGANIC BIOCHEMISTRY, 86(1), 248.
WoS2
2000 McDevitt, C., Burrell, P., Blackall, L., & McEwan, A. (2000). Aerobic nitrate respiration in a nitrite-oxidising bioreactor. FEMS Microbiology Letters, 184(1), 113-118.
DOI Scopus15 WoS17 Europe PMC5

Book Chapters

Conference Papers

Year Citation
2004 Mcewan, A., Bernhardt, P., Creevey, N., Hanson, G., & McDevitt, C. (2004). Ion motive electron transfer pathways involving type II molybdoenzymes of the DMSO reductase family. In BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS Vol. 1658 (pp. 16). Pisa, ITALY: ELSEVIER SCIENCE BV.
2003 Hanson, G., Noble, C., McDevitt, C., & McEwan, A. (2003). CW and pulsed EPR spectroscopy reveal a new structural motif for the active site Mo centre and an unusual [4Fe-4S](+) cluster in dimethylsulfide dehydrogenase.. In JOURNAL OF INORGANIC BIOCHEMISTRY Vol. 96 (pp. 142). CAIMS, AUSTRALIA: ELSEVIER SCIENCE INC.
DOI
2003 Hanson, G., Lane, I., Noble, C., McEwan, A., & Benson, N. (2003). Structural characterisation of the Mo(V) high-g unsplit species from Rhodobacter capsulatus dimethylsulfoxide reductase. In JOURNAL OF INORGANIC BIOCHEMISTRY Vol. 96 (pp. 142). CAIMS, AUSTRALIA: ELSEVIER SCIENCE INC.
2001 Hanson, G., Noble, C., Gates, K., & Burrage, K. (2001). XSophe, a computer simulation software suite for the analysis of electron paramagnetic resonance spectra.. In JOURNAL OF INORGANIC BIOCHEMISTRY Vol. 86 (pp. 248). ELSEVIER SCIENCE INC.
WoS2

Conference Items

Year Citation
2016 Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R., . . . McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. Poster session presented at the meeting of BioMetals 2016. Dresden, Germany.
2015 Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C., & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Poster session presented at the meeting of Abstract of BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC: BacPath & ASN Events.
2015 Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C., & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. Poster session presented at the meeting of An exchange workshop on antimicrobial resistance. UniSA.
2015 Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V., . . . Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Poster session presented at the meeting of RESPIROLOGY. Queensland, AUSTRALIA: WILEY-BLACKWELL.
2013 Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C., & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. Poster session presented at the meeting of School of Molecular and Biomedical Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of Australian Society for Microbiology Scientific Meeting.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of Membrane Transporters Workshop.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of Membrane Transporters Workshop.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of Australian Society for Microbiology BD Student Award.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of ASBMB ComBio.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. Poster session presented at the meeting of Faculty of Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. Poster session presented at the meeting of School of Molecular and Biomedical Sciences Postgraduate Symposium.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of Adelaide Protein Group.
2012 Pederick, V. G., Paton, J. C., & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. Poster session presented at the meeting of ABC2012 – 4th FEBS Special Meeting on ABC Proteins.
2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of School of Molecular and Biomedical Science Research Symposium.
2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of Australian Society for Medical Research SA Meeting.
2011 Pederick, V. G., Ween, M. P., Paton, J. C., & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Poster session presented at the meeting of Adelaide Protein Group.
Young, R., Begg, S., Sumby, C., & McDevitt, C. (n.d.). Silver Coordination Polymers: Relationships between structure and antibacterial activity. Poster session presented at the meeting of Unknown Conference.
DOI

Our research is supported by:

National Health and Medical Research Council (NHMRC)
  • Project Grant (CIA) - APP1140554 (2018–20) $843,035
  • Project Grant (CIB) - APP1145075 (2018–21) $784,541
  • Doherty Early Career Fellowship - Dr Stephanie Begg (2018-2021) $322,952
  • Project Grant (CIA) - APP1122582 (2017-2019) $870,924
  • Project Grant (CIB) - APP1080784 (2015-2017) $613,134
  • Project Grant (CIA) - APP1022240 (2012-2014) $568,375
  • Equipment Grant (CIA) - Liquid handling platform (2015) $20,870
  • Equipment Grant (CIA) - qRT-PCR equipment (2014) $40,000
  • Equipment Grant (CIA) - Spectrophotometric equipment - (2012) $35,500
  • Equipment Grant (CIA) - Refrigerated AKTA FPLC - (2011) $62,042
  • Equipment Grant (CIA) - Beckman Coulter Optima Max Biosafe Ultracentrifugation System - (2010) $78,000
  • Equipment Grant (CID) - Cell disruptor system - (2009) $22,000
  • Equipment Grant (CII) - Replacement Purification Systems - (2008) $28,401

Australian Research Council (ARC)

  • Future Fellowship - FT170100006 (2017-2021) $879,617
  • Discovery Project (CIA) - DP170102102 (2017-2019) $605,500
  • Discovery Project (CIB) - DP150104515 (2015-2017) $384,300
  • Discovery Project (CIA) - DP120103957 (2012-2014) $255,000
Channel 7 Children's Research Foundation
  • Project - Dr Bart Eijkelkamp (CIA) and Christopher McDevitt (CIB) - (2016) $35,000
  • Project - Ms Victoria Lewis (CIA) and Christopher McDevitt (CIB) - (2013) $31,000
  • Project (CIA) - (2010-2011) $98,000
Australian Cystic Fibrosis Foundation
  • Postgraduate Studentship Grant - (2011-2013) $15,000
Clive and Vera Ramaciotti Foundation
  • Equipment Grant (Coordinator) - Zetasizer Nano ZSP for protein characterisation and drug discovery - (2013) $54,783
  • Equipment Grant (Coordinator) - Instrumentation for cellular and subcellular analyses - (2012) $67,595
University of Adelaide
  • DVCR IRF Grant (CIE) Accelerating biological discovery through Artificial Intelligence - (2017) $90,000
  • DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (Bioruptor) - (2015) $50,000
  • DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (HPLC) - (2015) $28,000
  • IPAS Extending Collaborations Pilot Projects (CIB) - (2014) $16,000
  • IPAS Extending Collaborations Pilot Projects (CIB) - (2013) $8,500
  • DVCR Equipment Grant (CIA) - Temperature controlled shaking incubators - (2012) $81,136
  • DVCR Equipment Grant (CIA) - High speed centrifugation infrastructure - (2012) $365,813
  • Biomed IIA
  • Principles and Practice of Research (Advanced) II
  • Principles and Practice of Research (Advanced) III
  • Infection and Immunity IIA

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2018 Principal Supervisor Molecular basis of Zn(II) transport by the Adc permease Doctor of Philosophy Doctorate Full Time Ms Marina Lauren Zupan
2018 Co-Supervisor Enterobacterial Common Antigen Biosynthesis in Shigella Flexneri Doctor of Philosophy Doctorate Full Time Mr Nicholas Tadeusz Maczuga
2017 Principal Supervisor Metal Ion Homeostasis in Acinetobacter baumannii Doctor of Philosophy Doctorate Full Time Mr Saleh Fahad S Alquethamy
2016 Principal Supervisor The role of CzcD in Zinc homeostasis Doctor of Philosophy Doctorate Full Time Erin Bridget Brazel
2016 Co-Supervisor Development of Antibacterial Silver-based Coordination Polymers Doctor of Philosophy Doctorate Full Time Mr Harley Dwane Betts

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2014 - 2016 Principal Supervisor The Molecular Mechanisms of Metal Ion Homeostasis in Streptococcus pneumoniae Doctor of Philosophy Doctorate Full Time Stephanie Louise Begg
2013 - 2017 Principal Supervisor Characterisation of the Zinc Homeostatic Mechanisms of Streptococcus pneumoniae Doctor of Philosophy Doctorate Full Time Miss Jacqueline Rose Morey
2011 - 2015 Principal Supervisor Characterisation Of The ATP-Binding Cassette Tranporters of Pseudomonas aeruginosa Doctor of Philosophy Doctorate Full Time Dr Victoria Grace Pederick

Committee Memberships

Date Role Committee Institution Country
2015 - ongoing President Adelaide Protein Group
2015 - ongoing Member School of Biological Sciences Health, Safety & Wellbeing Committee University of Adelaide
2015 - ongoing Member School of Biological Sciences Research Committee University of Adelaide Australia
2013 - ongoing Representative EU COST Action Group - Molecular Machineries for Ion Translocation Across Biomembranes
2012 - 2015 Treasurer Adelaide Protein Group

Memberships

Date Role Membership Country
2010 - ongoing Australian Biophysical Society
2008 - ongoing Australian Society of Biochemistry and Molecular Biology
2004 - ongoing Representative UK Biochemical Society United Kingdom

Editorial Boards

Date Role Editorial Board Name Institution Country
2016 - ongoing Member Frontiers in Microbiology
2016 - ongoing Associate Editor Scientific Reports
2014 - ongoing Editor Frontiers in cellular and infection microbiology
Position
ARC Future Fellow
Phone
83130413
Campus
North Terrace
Building
Molecular Life Sciences, floor 4
Room Number
4 13
Org Unit
Molecular and Cellular Biology

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