Associate Professor Christopher McDevitt

Christopher McDevitt
ARC Future Fellow
School of Biological Sciences
Faculty of Sciences

Membrane proteins account for about one-third of the proteins encoded by every genome but, in contrast to soluble proteins, they are poorly characterised. The research in my laboratory, based in the Research Centre for Infectious Diseases (RCID), investigates how the integral membrane protein ATP-binding cassette (ABC) transporters contribute to the virulence of the major human pathogens Streptococcus pneumoniae (responsible for >1 million deaths annually) and Staphylococcus aureus (a health care burden of >$1 billion AUS annually). My work has already made major advances in our understanding of how metal ion ABC transporters contribute to the virulence of these pathogens and the chemical biology of the host-pathogen interface. By understanding how these transporters function, our work is also providing the foundation for translating basic science into effective antimicrobial therapies. Notably, our research has already identified a molecular role for zinc in resisting bacterial infection, which is highly important as nearly 2 billion people are zinc deficient, and demonstrated the potential to exploit these ABC uptake transporters as antimicrobial targets due to their essential requirement for bacterial virulence, a complete lack of human homologs, and their highly exposed and accessible location on the bacterial cell-surface.

The long-term goal of my research is to target these metal ion transporters with next generation antimicrobials, which will save over 1 million lives annually. My research to achieve this goal is focused, first on elucidating how bacterial pathogens, e.g. S. pneumoniae, facilitate metal ion homeostasis, and second how we can target these mechanisms to attenuate virulence in the host environment. To this end we will continue to study the structure/function relationships of how these metal recruiting proteins work and then exploit our cutting edge knowledge, in which we are acknowledged world-leaders, to develop the next generation of antimicrobial therapeutic agents.

Associate Professor Christopher McDevitt

Membrane proteins account for about one-third of the proteins encoded by every genome but, in contrast to soluble proteins, they are poorly characterised. The research in my laboratory, based in the Research Centre for Infectious Diseases (RCID), investigates how the integral membrane protein ATP-binding cassette (ABC) transporters contribute to the virulence of the major human pathogens Streptococcus pneumoniae (responsible for >1 million deaths annually) and Staphylococcus aureus (a health care burden of >$1 billion AUS annually). My work has already made major advances in our understanding of how metal ion ABC transporters contribute to the virulence of these pathogens and the chemical biology of the host-pathogen interface. By understanding how these transporters function, our work is also providing the foundation for translating basic science into effective antimicrobial therapies. Notably, our research has already identified a molecular role for zinc in resisting bacterial infection, which is highly important as nearly 2 billion people are zinc deficient, and demonstrated the potential to exploit these ABC uptake transporters as antimicrobial targets due to their essential requirement for bacterial virulence, a complete lack of human homologs, and their highly exposed and accessible location on the bacterial cell-surface.

The long-term goal of my research is to target these metal ion transporters with next generation antimicrobials, which will save over 1 million lives annually. My research to achieve this goal is focused, first on elucidating how bacterial pathogens, e.g. S. pneumoniae, facilitate metal ion homeostasis, and second how we can target these mechanisms to attenuate virulence in the host environment. To this end we will continue to study the structure/function relationships of how these metal recruiting proteins work and then exploit our cutting edge knowledge, in which we are acknowledged world-leaders, to develop the next generation of antimicrobial therapeutic agents.

The projects in my laboratory (www.mcdevittlab.org) are focused on studying metal ion transporters of pathogenic bacteria. Bacterial infections are highly dependent on metal ion micronutrients. The high affinity metal ion uptake pathways are transporters called ATP-binding cassette (ABC) permeases. These transporters acquire metal ions from the extracellular host environment. Of particular interest to our group are the metal ions zinc and manganese, the second and third most abundant transition metal ions in living organisms. Manganese has essential roles during infection and colonization, where it serves in carbon metabolism and oxidative stress response. Zinc is a vital cofactor for numerous host and bacterial cellular functions. The manganese and zinc ABC uptake transporters have been shown to be essential for the virulence of a number of human pathogens including Streptococcus pneumoniae.

1. Manganese uptake in Streptococcus pneumoniae and other pathogens

Bacterial pathogens must scavenge their metal ions from the host environment in order to mediate virulence. Streptococcus pneumoniae is the world's foremost bacterial pathogen and is responsible for more than one million deaths every year. In terms of relative disease burden, it is the largest bacterial killer of young children and kills more children every year than AIDs, tuberculosis and malaria combined. However, its ability to infect and cause disease are dependent on the acquistion of metal ions, one of which is the transition row metal ion manganese. Loss of manganese uptake completely prevents its ability to cause disease.

PsaA transition to closed state
Apo-PsaA transition to closed metal-bound conformation.

Our group seeks to understand how S. pneumoniae, and other pathogens, scavenge manganese from the host environment. Although it was known an ABC importer was involved in this process, the underlying details were pooly understood. Recently we revealed the mechanism by which S. pneumoniae scavenges manganese from the host environment and how another metal ion, zinc, interfered with this process. We found that the manganese recruiting protein, PsaA, used a 'spring-hammer' mechanism to bind metal ions, in which half of the protein pivoted and closed over the other half.

There are still many unanswered questions that we are currently investigating. These include how is this ABC importer is selective for manganese ions, how are these ions are translocated into the bacterial cell, and how does the host prevent manganese from being scavenged by the bacteria during infection. Answering these questions will provide the necessary information to design the next generation of antimicrobial agents to target this essential bacterial pathway.

2. Zinc homeostasis in Streptococcus pneumoniae

Zn homeostasis mechanisms of S. pneumoniae
Zn homeostasis mechanisms of S. pneumoniae

Zinc is the second most abundant transition row element in biological systems. This metal ion has crucial roles in numerous cellular processes such as transcription, translation, catalysis and metabolism. As with all nutrients, pathogenic bacteria must scavenge zinc from the host in order to mediate disease.

Our studies have shown that manganese and zinc have an unusual relationship in S. pneumoniae, where zinc can actually block the manganese ABC importer. So we are seeking to  understand how zinc is acquired and managed in this organism. Recently work from our lab identified that zinc uptake in S. pneumoniae, although similar to manganese uptake, was regulated in a more complex manner. Intriguingly zinc was recruited by 2  proteins, AdcA and AdcAII. A number of possible models have been proposed for how these proteins work together to recruit zinc.

Work in our group is focused on understanding how zinc is sensed by S. pneumoniae, how is zinc managed once it has been translocated into the cell, and how does the host utilise zinc during infection. The answers we obtain to these questions will lead to new ways to target this major human pathogen and its need for zinc.

Research Opportunities

Undergraduate: My laboratory has opportunities for enthusiastic undergraduate students who would like to improve their laboratory skills in an actual research environment.  We currently offer placements for select undergraduates during the year who wish to undertake a small amount of research training (1 or 2 days a week) in preparation for Honours. For more information about opportunities please contact me.

Honours: My laboratory has 4 multidisciplinary Honours projects on offer in 2017 that combine genetics and biochemistry to study the virulence mechanisms of major bacterial pathogens. A project in my lab will provide you with a strong set of research skills ideally suited for a job in science or further PhD research. Please see my webpage for further details.

Appointments

Date Position Institution name
2017 ARC Future Fellow University of Adelaide, Adelaide
2017 Associate Professor University of Adelaide
2016 Deputy Director, Australian Centre for Antimicrobial Resistance Ecology Universiy of Adelaide
2014 Deputy Director, Research Centre for Infectious Diseases University of Adelaide
2008 NHMRC Research Fellow University of Adelaide
2005 - 2008 Senior Research Associate University of Oxford
2002 - 2005 Research Associate University of Oxford

Awards and Achievements

Date Type Title Institution Name Amount
2011 Award RCDN Mid-Career Research Award The University of Adelaide
2007 - 2008 Fellowship EPA Cephalosporin Junior Research Fellow Linacre College, University of Oxford

Education

Date Institution name Country Title
University of Queensland Australia PhD
University of Queensland Australia BSc (Hons)

Research Interests

Infectious Diseases, Medical Bacteriology, Medical Microbiology, Proteomics and Intermolecular Interactions, Receptors and Membrane Biology, Transition Metal Chemistry

Journals

Year Citation
2017 Trappetti, C., McAllister, L., Chen, A., Wang, H., Paton, A., Oggioni, M. ... Paton, J. (2017). Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by streptococcus pneumoniae, resulting in hypervirulence. L. McDaniel (Ed.). mBio, 8, 1, e02269-16-1-e02269-16-18.
10.1128/mBio.02269-16
2017 Martin, J., Edmonds, K., Bruce, K., Campanello, G., Eijkelkamp, B., Brazel, E. ... Giedroc, D. (2017). The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity. Molecular Microbiology, 104, 4, 636-651.
10.1111/mmi.13654
2017 Hassan, K., Pederick, V., Elbourne, L., Paulsen, I., Paton, J., McDevitt, C. & Eijkelkamp, B. (2017). Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology, 17, 1, 59-1-59-15.
10.1186/s12866-017-0965-y
2017 Eyre, N. S., Johnson, S. M., Eltahla, A. A., Aloi, M., Aloia, A. L., McDevitt, C. A. ... Beard, M. R. (2017). Genome-wide mutagenesis of dengue virus reveals plasticity of the NS1 protein and enables generation of infectious tagged reporter viruses.. Journal of virology, JVI.01455-17-JVI.01455-17.
10.1128/jvi.01455-17
2016 Heng, S., McDevitt, C., Kostecki, R., Morey, J., Eijkelkamp, B., Ebendorff-Heidepriem, H. ... Abell, A. (2016). Microstructured optical fiber-based biosensors: reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces, 8, 20, 12727-12732.
10.1021/acsami.6b03565
2015 Morey, J., McDevitt, C. & Kehl-Fie, T. (2015). Host-imposed manganese starvation of invading pathogens: two routes to the same destination. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28, 3, 509-519.
10.1007/s10534-015-9850-z
2015 Eijkelkamp, B., Pederick, V., Plumptre, C., Harvey, R., Hughes, C., Paton, J. & McDevitt, C. (2015). The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. A. Camilli (Ed.). Infection and Immunity, 84, 2, 407-415.
10.1128/IAI.01082-15
2015 Eijkelkamp, B. A., McDevitt, C. A. & Kitten, T. (2015). Manganese uptake and streptococcal virulence. Biometals, 28, 3, 491-508.
10.1007/s10534-015-9826-z
2015 Luo, Z., Morey, J., McDevitt, C. & Kobe, B. (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica Section F: Structural Biology Communications, 71, Pt 12, 1459-1464.
10.1107/S2053230X15021330
2015 Bajaj, M., Mamidyala, S., Zuegg, J., Begg, S., Ween, M., Luo, Z. ... Cooper, M. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10, 6, 1511-1520.
10.1021/cb501032x
2015 Pederick, V., Eijkelkamp, B., Begg, S., Ween, M., McAllister, L., Paton, J. & McDevitt, C. (2015). ZnuA and zinc homeostasis in pseudomonas aeruginosa. Scientific Reports, 5, 1, 13139-1-13139-14.
10.1038/srep13139
2015 Begg, S. L., Eijkelkamp, B. A., Luo, Z., Couñago, R. M., Morey, J. R., Maher, M. J. ... McDevitt, C. A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6, 6418, 6418-1-6418-11.
10.1038/ncomms7418
2015 Deplazes, E., Begg, S., van Wonderen, J., Campbell, R., Kobe, B., Paton, J. ... O'Mara, M. (2015). Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60.
10.1016/j.bpc.2015.08.004
2014 Counago, R., Ween, M., Begg, S., Bajaj, M., Zuegg, J., O'Mara, M. ... McDevitt, C. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10, 1, 35-43.
10.1038/NCHEMBIO.1382
2014 Van Wonderen, J., McMahon, R., OMara, M., McDevitt, C., Thomson, A., Kerr, I. ... Callaghan, R. (2014). The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal, 281, 9, 2190-2201.
10.1111/febs.12773
2014 Pederick, V., Eijkelkamp, B., Ween, M., Begg, S., Paton, J. & McDevitt, C. (2014). Acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology, 80, 21, 6843-6852.
10.1128/aem.02465-14
2014 Plumptre, C. D., Hughes, C. E., Harvey, R. M., Eijkelkamp, B. A., McDevitt, C. A. & Paton, J. C. (2014). Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity, 82, 10, 4315-4324.
10.1128/IAI.02155-14
2014 Plumptre, C., Eijkelkamp, B., Morey, J., Behr, F., Couñago, R., Ogunniyi, A. ... McDevitt, C. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91, 4, 834-851.
10.1111/mmi.12504
2014 Eijkelkamp, B., Morey, J., Ween, M., Ong, C., McEwan, A., Paton, J. & McDevitt, C. (2014). Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae. PLoS One, 9, 2, e89427-1-e89427-11.
10.1371/journal.pone.0089427
2014 Pollock, N., McDevitt, C., Collins, R., Niesten, P., Prince, S., Kerr, I. ... Callaghan, R. (2014). Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochimica et Biophysica Acta-Biomembranes, 1838, 1, 134-147.
10.1016/j.bbamem.2013.09.001
2013 Heng, S., McDevitt, C., Stubing, D., Whittall, J., Thompson, J., Engler, T. ... Monro, T. (2013). Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules, 14, 10, 3376-3379.
10.1021/bm401040v
2012 Pederick, V., Ween, M. & McDevitt, C. (2012). The role of ATP-binding cassette transporters in bacterial pathogenicity. Protoplasma, 249, 4, 919-942.
10.1007/s00709-011-0360-8
2012 Counago, R., McDevitt, C., Ween, M. & Kobe, B. (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13, 11, 1400-1410.
10.2174/138945012803530170
2012 Lehane, A., McDevitt, C., Kirk, K. & Fidock, D. (2012). Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?. International Journal for Parasitology: Drugs and Drug Resistance, 2, 47-57.
10.1016/j.ijpddr.2011.11.001
2011 McDevitt, C., Ogunniyi, A., Valkov, E., Lawrence, M., Kobe, B., McEwan, A. & Paton, J. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7, 11, 2357-2365.
10.1371/journal.ppat.1002357
2010 Ogunniyi, A., Mahdi, L., Jennings, M., McEwan, A., McDevitt, C., Van der Hoek, M. ... Paton, J. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. Journal of Bacteriology, 192, 17, 4489-4497.
10.1128/JB.00064-10
2009 McDevitt, C., Collins, R., Kerr, I. & Callaghan, R. (2009). Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews, 61, 1, 57-65.
10.1016/j.addr.2008.07.004
2008 McDevitt, C., Crowley, E., Hobbs, G., Starr, K., Kerr, I. & Callaghan, R. (2008). Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?. FEBS Journal, 275, 17, 4354-4362.
10.1111/j.1742-4658.2008.06578.x
2008 McDevitt, C., Shintre, C., Grossmann, G., Pollock, N., Prince, S., Callaghan, R. & Ford, R. (2008). Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.. FEBS Letters, 582, 19, 2950-2956.
10.1016/j.febslet.2008.07.022
2007 McDevitt, C. & Callaghan, R. (2007). How can we best use structural information on P-glycoprotein to design inhibitors?. Pharmacology & Therapeutics, 113, 2, 429-441.
10.1016/j.pharmthera.2006.10.003
2006 McDevitt, C., Collins, R., Conway, M., Modok, S., Storm, J., Kerr, I. ... Callaghan, R. (2006). Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure, 14, 11, 1623-1632.
10.1016/j.str.2006.08.014
2006 McDevitt, C., Sargent, F., Palmer, T., Berks, B. & Buchanan, G. (2006). Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal, 273, 24, 5656-5668.
10.1111/j.1742-4658.2006.05554.x
2005 Gohlke, U., Pullan, L., McDevitt, C., Porcelli, I., de Leeuw, E., Palmer, T. ... Berks, B. (2005). The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proceedings of the National Academy of Sciences of the United States of America, 102, 30, 10482-10486.
10.1073/pnas.0503558102
2005 McDevitt, C., Hicks, M., Palmer, T. & Berks, B. (2005). Characterisation of Tat protein transport complexes carrying inactivating mutations. Biochemical and Biophysical Research Communications, 329, 2, 693-698.
10.1016/j.bbrc.2005.02.038
2002 McEwan, A., Ridge, J., McDevitt, C. & Hugenholtz, P. (2002). The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal, 19, 1, 3-21.
10.1080/014904502317246138
2002 McDevitt, C., Hugenholtz, P., Hanson, G. & McEwan, A. (2002). Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: Its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology, 44, 6, 1575-1587.
10.1046/j.1365-2958.2002.02978.x
2002 McDevitt, C., Hanson, G., Noble, C., Cheesman, M. & McEwan, A. (2002). Characterization of the redox centers in dimethyl sulfide dehydrogenase from Rhodovulum sulfidophilum. Biochemistry, 41, 51, 15234-15244.
10.1021/bi026221u
2001 Hanson, G., McDevitt, C. & McEwan, A. (2001). Dimethylsulfide dehydrogenase from rhodovulum sulfidophilum: EPR spectroscopy and biochemical analysis reveal its place in the DMSO reductase family of molybdenum enzymes. JOURNAL OF INORGANIC BIOCHEMISTRY, 86, 1, 248-248.
2000 McDevitt, C., Burrell, P., Blackall, L. & McEwan, A. (2000). Aerobic nitrate respiration in a nitrite-oxidising bioreactor. FEMS Microbiology Letters, 184, 1, 113-118.
10.1016/S0378-1097(00)00030-6

Book Chapters

Year Citation
2016 McDevitt, C., Begg, S. & Paton, J. (2016). Metal ion Toxicity and Oxidative Stress in Streptococcus Pneumoniae. In F. de Burjin (Ed.), Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria (pp. 1184-1193). Hoboken, NJ, USA: John Wiley & Sons, Inc..
10.1002/9781119004813.ch115
2010 Crowley, E., McDevitt, C. & Callaghan, R. (2010). Generating inhibitors of P-glycoprotein: where to, now?. In J. Zhou (Ed.), Multi-drug resistance in cancer (pp. 405-432). United States of America: Humana Press.
10.1007/978-1-60761-416-6_18
2004 McEwan, A., Kappler, U. & McDevitt, C. (2004). Microbial molybdenum-containing enzymes in respiration: Structural and functional aspects. In Davide Zannoni (Ed.), Respiration in Archaea and Bacteria: Diversity of Prokaryotic Respiratory Systems (pp. 175-202). The Netherlands: Kluwer Academic Publishers.

Conference Papers

Year Citation
2004 Mcewan, A., Bernhardt, P., Creevey, N., Hanson, G. & McDevitt, C. (2004). Ion motive electron transfer pathways involving type II molybdoenzymes of the DMSO reductase family. 13th European Bioenergetics Conference (EBEC 2004). Pisa, ITALY.
2003 Hanson, G., Noble, C., McDevitt, C. & McEwan, A. (2003). CW and pulsed EPR spectroscopy reveal a new structural motif for the active site Mo centre and an unusual [4Fe-4S](+) cluster in dimethylsulfide dehydrogenase.. 11th International Conference on Biological Inorganic Chemistry. CAIMS, AUSTRALIA.
10.1016/S0162-0134(03)80633-5

Conference Items

Year Citation
2016 Pederick, V. G., Eijkelkamp, B. A., Plumptre, C. D., Harvey, R. M., Hughes, C. E., Morey, J. R. ... McDevitt, C. A. (2016). The role of Pht proteins in pneumococcal zinc acquisition. BioMetals 2016. Dresden, Germany.
2015 Pederick, V. G., Eijkelkamp, B. A., Begg, S. L., Ween, M. P., McAllister, L. J., Paton, J. C. & McDevitt, C. A. (2015). ZnuA and zinc homeostasis in Pseudomonas aeruginosa. BacPath 13: Molecular Analysis of Bacterial Pathogens Conference 2015. Phillip Island, VIC.
2015 Goddard, T., Parsons, M., Butler, R., Miller, D., Mcdevitt, C., Pederick, V. ... Parsons, D. (2015). IDENTIFICATION OF VOLATILE ORGANIC COMPOUND DIFFERENCES IN PSEUDOMONAS AERUGINOSA EPIDEMIC STRAINS VIA MS-SIFT GAS ANALYSIS. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015. Queensland, AUSTRALIA.
2015 Pederick, V. G., Begg, S. L., eijkelkamp, B. A., ween, M. P., Paton, J. C. & McDevitt, C. A. (2015). Metal uptake transporters – a microbial Achilles heel. An exchange workshop on antimicrobial resistance. UniSA.
2013 Pederick, V. G., Eijkelkamp, B. A., Ween, M. P., Begg, S. L., Paton, J. C. & McDevitt, C. A. (2013). The role of molybdenum in Pseudomonas aeruginosa persistence. School of Molecular and Biomedical Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. ASBMB ComBio.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology Scientific Meeting.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. Faculty of Sciences 3-Minute Thesis competition.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. Adelaide Protein Group.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). The need to breathe: stopping bacterial colonization in cystic fibrosis. School of Molecular and Biomedical Sciences Postgraduate Symposium.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Australian Society for Microbiology BD Student Award.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I secretion system from Pseudomonas aeruginosa. ABC2012 – 4th FEBS Special Meeting on ABC Proteins.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.
2012 Pederick, V. G., Paton, J. C. & McDevitt, C. A. (2012). Characterisation of a Type I Secretion system from Pseudomonas aeruginosa. Membrane Transporters Workshop.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Australian Society for Medical Research SA Meeting.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a novel Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. School of Molecular and Biomedical Science Research Symposium.
2011 Pederick, V. G., Ween, M. P., Paton, J. C. & McDevitt, C. A. (2011). Biochemical characterisation of PA1876, a Pseudomonas aeruginosa multidrug ATP-binding cassette transporter. Adelaide Protein Group.

Our research is supported by:

National Health and Medical Research Council (NHMRC)
  • Project Grant (CIA) - APP1122582 (2017-2019) $870,924
  • Project Grant (CIB) - APP1080784 (2015-2017) $613,134
  • Project Grant (CIA) - APP1022240 (2012-2014) $568,375
  • Equipment Grant (CIA) - Liquid handling platform (2015) $20,870
  • Equipment Grant (CIA) - qRT-PCR equipment (2014) $40,000
  • Equipment Grant (CIA) - Spectrophotometric equipment - (2012) $35,500
  • Equipment Grant (CIA) - Refrigerated AKTA FPLC - (2011) $62,042
  • Equipment Grant (CIA) - Beckman Coulter Optima Max Biosafe Ultracentrifugation System - (2010) $78,000
  • Equipment Grant (CID) - Cell disruptor system - (2009) $22,000
  • Equipment Grant (CII) - Replacement Purification Systems - (2008) $28,401

Australian Research Council (ARC)

  • Future Fellowship - FT170100006 (2017-2021) $879,617
  • Discovery Project (CIA) - DP170102102 (2017-2019) $605,500
  • Discovery Project (CIB) - DP150104515 (2015-2017) $384,300
  • Discovery Project (CIA) - DP120103957 (2012-2014) $255,000
Channel 7 Children's Research Foundation
  • Project - Dr Bart Eijkelkamp (CIA) and Christopher McDevitt (CIB) - (2016) $35,000
  • Project - Ms Victoria Lewis (CIA) and Christopher McDevitt (CIB) - (2013) $31,000
  • Project (CIA) - (2010-2011) $98,000
Australian Cystic Fibrosis Foundation
  • Postgraduate Studentship Grant - (2011-2013) $15,000
Clive and Vera Ramaciotti Foundation
  • Equipment Grant (Coordinator) - Zetasizer Nano ZSP for protein characterisation and drug discovery - (2013) $54,783
  • Equipment Grant (Coordinator) - Instrumentation for cellular and subcellular analyses - (2012) $67,595
University of Adelaide
  • DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (Bioruptor) - (2015) $50,000
  • DVCR IRF Grant (CIA) Metalloproteomics infrastructure grant (HPLC) - (2015) $28,000
  • IPAS Extending Collaborations Pilot Projects (CIB) - (2014) $16,000
  • IPAS Extending Collaborations Pilot Projects (CIB) - (2013) $8,500
  • DVCR Equipment Grant (CIA) - Temperature controlled shaking incubators - (2012) $81,136
  • DVCR Equipment Grant (CIA) - High speed centrifugation infrastructure - (2012) $365,813
  • Biomed IIA
  • Principles and Practice of Research (Advanced) II
  • Infection and Immunity IIA
PhD Current
  • Principal supervisor – Jacqueline Morey
  • Principal supervisor – Erin Brazel
  • Co-Supervisor – Harley Betts
PhD Completions
  • Principal supervisor – Dr Stephanie Begg (University of Adelaide; completed 2016)
    • Dean’s Commendation for Doctoral Thesis Excellence (2016); The Australian Federation of Graduate Women Barbara Hale Fellowship (2015) $8,000; Adelaide Protein Group Annual Student Award Event Oral Prize (2015); 5th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins Best Poster Prize (2014)
  • Principal supervisor – Dr Victoria Pederick (University of Adelaide; completed 2015)
    • Channel 7 Children’s Research Foundation ECR Grant (2013) $31,000; Australian Cystic Fibrosis Foundation Postgraduate Studentship Grant (2011-2013) $15,000; The Australian Society for Microbiology Annual Scientific Meeting Poster Prize (2013); Best oral presentation – Annual Postgraduate Symposium, School of Molecular and Biomedical Science (2012); Adelaide Protein Group Student Award Event Best Poster (2012)
  • Co-supervisor – Zhenyao Luo (University of Queensland; completed 2015)
Honours Completions
  • Principal supervisor – Marina Zupan (2017)
  • Principal supervisor – Kimberley McLean (2017)
Honours Completions
  • Principal supervisor – Erin Brazel (First Class, 2015; Derrick Rowley Microbiology & Immunology Prize Winner)
  • Principal supervisor – Amy Burns (First Class, 2015)
  • Principal supervisor – Jacqueline Morey (First Class, 2012)
  • Principal supervisor –  Jonathan Whittall (First Class, 2012)
  • Principal supervisor – Victoria Lewis (First Class, 2010)

Memberships

Date Role Membership Country
2010 - ongoing Australian Biophysical Society
2008 - ongoing Australian Society of Biochemistry and Molecular Biology
2004 - ongoing Representative UK Biochemical Society United Kingdom

Committee Memberships

Date Role Committee Institution Country
2015 - ongoing President Adelaide Protein Group
2015 - ongoing Member School of Biological Sciences Health, Safety & Wellbeing Committee University of Adelaide
2015 - ongoing Member School of Biological Sciences Research Committee University of Adelaide Australia
2013 - ongoing Representative EU COST Action Group - Molecular Machineries for Ion Translocation Across Biomembranes
2012 - 2015 Treasurer Adelaide Protein Group

Editorial Boards

Date Role Editorial Board Name Country
2016 - ongoing Member Frontiers in Microbiology
2016 - ongoing Associate Editor Scientific Reports
2014 - ongoing Editor Frontiers in cellular and infection microbiology
Position
ARC Future Fellow
Phone
83130413
Campus
North Terrace
Building
Molecular Life Sciences
Room Number
4 13
Org Unit
Molecular and Cellular Biology

top