Christopher Hahn

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Christopher N Hahn, PhD
SA Pathology Department of Genetics and Molecular Pathology Frome Rd, Adelaide.

Molecular Pathology Research Laboratory:
All disease processes in humans have a genetic component, either inherited or acquired by somatic mutation during cell division. It is important to identify genes and mutations that cause disease, predispose families to diseases, or are acquired during disease progression as these are important diagnostic and prognostic markers. They also provide direct targets and biological pathways for therapeutic intervention.

We are interested in how and why genetic mutations occur, how these changes cause diseases or disease predisposition such as cancer and autoimmunity, and ways of better treating and monitoring these diseases. Our model diseases are typically, blood cell diseases, such as leukaemias, lymphomas and autoimmunity (such as arthritis). We also work on rare or orphan diseases with unmet clinical needs, such as genetic diagnoses for family planning.

Our department is co-located with the ACRF Cancer Genomics Facility, which provides access to powerful cutting edge genetic/genomic technologies including bioinformatics, next-generation sequencing and sample preparation robotics. The Department performs both basic and translational research, which includes implementing these new technologies into its diagnostic tests for personalized medicine.

Career
Publications
Supervision
Contact

Appointments

Date	Position	Institution name
2020 - ongoing	Adjunct Associate Professor	University of South Australia
2019 - ongoing	Affiliate Senior Lecturer	University of Adelaide
2018 - ongoing	Associate Member of the Centre for Cancer Biology Faculty	Centre for Cancer Biology
2008 - ongoing	Section Head - Molecular Pathology Research Laboratory	SA Pathology

Language Competencies

Language Competency

English Can read, write, speak, understand spoken and peer review
Education

Date Institution name Country Title

1987 - 1991 University of Adelaide Australia PhD
Research Interests

Cancer Cell Biology Cancer Diagnosis Cancer Genetics Genetically Modified Animals Genetics & Heredity Oncology and Carcinogenesis Cancer Biology and Clinical Oncology Translational Health Outcomes

Language	Competency
English	Can read, write, speak, understand spoken and peer review

Date	Institution name	Country	Title
1987 - 1991	University of Adelaide	Australia	PhD

Journals

Year	Citation
2022	Feurstein, S., Hahn, C. N., Mehta, N., & Godley, L. A. (2022). A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias. Genetics in Medicine, 24(4), 931-954. DOI Scopus1 WoS1
2022	Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15. DOI Scopus2 WoS2
2022	Drazer, M. W., Homan, C. C., Yu, K., de Andrade Silva, M. C., McNeely, K. E., Pozsgai, M. J., . . . Godley, L. A. (2022). Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations. Blood Advances, 6(15), 4357-4359. DOI
2022	Samaraweera, S. E., Geukens, T., Casolari, D. A., Nguyen, T., Sun, C., Bailey, S., . . . Ross, D. M. (2022). Novel modes of MPL activation in triple-negative myeloproliferative neoplasms. Pathology, 9 pages. DOI
2022	Baranwal, A., Hahn, C. N., Shah, M. V., & Hiwase, D. K. (2022). Role of Germline Predisposition to Therapy-Related Myeloid Neoplasms. Current Hematologic Malignancy Reports, 12 pages. DOI
2022	Saygin, C., Roloff, G. W., Hahn, C. N., Chhetri, R., Gill, S. I., Elmariah, H., . . . Godley, L. A. (2022). Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies.. Blood advances, bloodadvances.2022008172. DOI
2022	Feurstein, S., Luo, X., Shah, M., Walker, T., Mehta, N., Wu, D., . . . Zhang, L. (2022). Revision of RUNX1 variant curation rules. Blood Advances, 6(16), 4726-4730. DOI
2021	Singhal, D., Hahn, C. N., Feurstein, S., Wee, L. Y. A., Moma, L., Kutyna, M. M., . . . Hiwase, D. K. (2021). Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer. Leukemia, 35(11), 3245-3256. DOI Scopus17 WoS16 Europe PMC3
2021	Homan, C. C., King-Smith, S. L., Lawrence, D. M., Arts, P., Feng, J., Andrews, J., . . . Brown, A. L. (2021). The RUNX1 database (RUNX1db): Establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Haematologica, 106(11), 3004-3007. DOI Scopus9 WoS7 Europe PMC3
2021	Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). GATA2 deficiency syndrome: a decade of discovery. Human Mutation, 42(11), 1399-1421. DOI Scopus4 WoS4
2021	Samaraweera, S. E., Wang, P. P. S., Li, K. L., Casolari, D. A., Feng, J., Pinese, M., . . . D'Andrea, R. J. (2021). Childhood acute myeloid leukemia shows a high level of germline predisposition. Blood, 138(22), 2293-2298. DOI Scopus3 WoS3
2021	Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). Cover, Volume 42, Issue 11. Human Mutation, 42(11). DOI
2020	Venugopal, P., Gagliardi, L., Forsyth, C., Feng, J., Phillips, K., Babic, M., . . . Scott, H. S. (2020). Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss. BMC Medical Genetics, 21(1), 35-1-35-5. DOI Scopus2 WoS2 Europe PMC2
2020	Brown, A. L., Arts, P., Carmichael, C. L., Babic, M., Dobbins, J., Chong, C. -E., . . . Scott, H. S. (2020). RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Advances, 4(6), 1131-1144. DOI Scopus49 WoS49 Europe PMC21
2020	Brown, A. L., Hahn, C. N., & Scott, H. S. (2020). Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA). Blood, 136(1), 24-35. DOI Scopus35 WoS35 Europe PMC22
2020	Fox, L. C., Tan, M., Brown, A. L., Arts, P., Thompson, E., Ryland, G. L., . . . Blombery, P. (2020). A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability. British Journal of Haematology, 190(5), e297-e301. DOI Scopus10 WoS10 Europe PMC4
2020	Brown, A. L., Hahn, C., Hiwase, D., Godley, L. A., & Scott, H. S. (2020). Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis. LEUKEMIA & LYMPHOMA, 61(1), 2 pages. DOI Scopus2 WoS2 Europe PMC1
2019	Byrne, A. B., Arts, P., Polyak, S. W., Feng, J., Schreiber, A. W., Kassahn, K. S., . . . Scott, H. S. (2019). Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6. npj Genomic Medicine, 4(1), 1-8. DOI Scopus10 WoS6 Europe PMC7
2019	Singhal, D., Wee, L. Y. A., Kutyna, M. M., Chhetri, R., Geoghegan, J., Schreiber, A. W., . . . Hiwase, D. K. (2019). The mutational burden of therapy-related myeloid neoplasms is similar to primary myelodysplastic syndrome but has a distinctive distribution. Leukemia, 33(12), 2842-2853. DOI Scopus26 WoS25 Europe PMC14
2019	Cheah, J. J. C., Brown, A. L., Schreiber, A. W., Feng, J., Babic, M., Moore, S., . . . Scott, H. S. (2019). A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia. Haematologica, 104(7), e318-e321. DOI Scopus10 WoS9 Europe PMC6
2019	Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704. DOI Scopus64 WoS65 Europe PMC33
2018	Al Seraihi, A. F., Rio-Machin, A., Tawana, K., Bödör, C., Wang, J., Nagano, A., . . . Fitzgibbon, J. (2018). GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML. Leukemia, 32(11), 2502-2507. DOI Scopus35 WoS35 Europe PMC25
2018	Branford, S., Wang, P., Yeung, D. T., Thomson, D., Purins, A., Wadham, C., . . . Hughes, T. P. (2018). Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease. Blood, 132(9), 948-961. DOI Scopus98 WoS95 Europe PMC51
2018	Beck, D., Thoms, J., Palu, C., Herold, T., Shah, A., Olivier, J., . . . Pimanda, J. (2018). A four-gene lincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients. Leukemia, 32(2), 263-272. DOI Scopus25 WoS23 Europe PMC12
2018	Chong, C. -E., Venugopal, P., Stokes, P., Lee, Y., Brautigan, P., Yeung, D., . . . Scott, H. (2018). Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes. Leukemia, 32(1), 194-202. DOI Scopus38 WoS37 Europe PMC17
2017	Carruthers, V., Nicola, M., Venugopal, P., Hahn, C. N., Scott, H. S., & Revesz, T. (2017). Clinical implications of transient myeloproliferative disorder in a neonate without Down syndrome features. Journal of Paediatrics and Child Health, 53(10), 1018-1020. DOI Scopus1 WoS1 Europe PMC1
2017	Pagani, I. S., Kok, C. H., Saunders, V. A., Van der Hoek, M. B., Heatley, S. L., Schwarer, A. P., . . . Ross, D. M. (2017). A method for next-generation sequencing of paired diagnostic and remission Samples to detect mitochondrial DNA mutations associated with leukemia. The Journal of molecular diagnostics : JMD, 19(5), 711-721. DOI Scopus5 WoS4 Europe PMC4
2017	Oftedal, B., Ardesjö Lundgren, B., Hamm, D., Gan, P., Holdsworth, S., Hahn, C., . . . Scott, H. (2017). T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Journal of Autoimmunity, 81, 1-10. DOI Scopus5 WoS4 Europe PMC2
2017	Casolari, D., Nguyen, T., Butcher, C., Iarossi, D., Hahn, C., Bray, S., . . . D'Andrea, R. (2017). A novel, somatic, transforming mutation in the extracellular domain of epidermal growth factor receptor identified in myeloproliferative neoplasm. Scientific Reports, 7(1), 2467-1-2467-9. DOI Scopus5 WoS4 Europe PMC3
2017	Cheah, J., Hahn, C., Hiwase, D., Scott, H., & Brown, A. (2017). Myeloid neoplasms with germline DDX41 mutation. International Journal of Hematology, 106(2), 163-174. DOI Scopus54 WoS49 Europe PMC28
2017	Tiong, I., Casolari, D., Moore, S., Nguyen, T., Van Velzen, M., Zantomio, D., . . . Ross, D. (2017). Apparent ‘JAK2-negative’ polycythaemia vera due to compound mutations in exon 14. British Journal of Haematology, 178(2), 333-336. DOI Scopus9 WoS8 Europe PMC2
2017	Venugopal, P., Moore, S., Lawrence, D., George, A., Hannan, R., Bray, S., . . . Scott, H. (2017). Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan Anemia patient. Haematologica, 102(12), e506-e509. DOI Scopus18 WoS18 Europe PMC11
2017	De Sousa, S. M. C., Stowasser, M., Feng, J., Schreiber, A. W., Wang, P., Hahn, C. N., . . . Gagliardi, L. (2017). ARMC5 is not implicated in familial hyperaldosteronism type II (FH-II). Journal of Human Hypertension, 31(12), 857-859. DOI Scopus3 WoS1 Europe PMC3
2016	Barnett, C., Nataren, N., Klingler-Hoffmann, M., Schwarz, Q., Chong, C., Lee, Y., . . . Scott, H. (2016). Ectrodactyly and lethal pulmonary acinar dysplasia associated with homozygous FGFR2 mutations identified by exome sequencing. Human Mutation, 37(9), 955-963. DOI Scopus21 WoS17 Europe PMC13
2016	Barnett, C. P., Nataren, N. J., Klingler-Hoffmann, M., Schwarz, Q., Chong, C. E., Lee, Y. K., . . . Scott, H. S. (2016). Cover Image, Volume 37, Issue 9. Human Mutation, 37(9), i. DOI
2016	Ross, D., Altamura, H., Hahn, C., Nicola, M., Yeoman, A., Holloway, M., . . . Scott, H. (2016). Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene. Leukemia, 30(6), 1402-1405. DOI Scopus5 WoS5 Europe PMC4
2016	Lewinsohn, M., Brown, A. L., Weinel, L. M., Phung, C., Rafidi, G., Lee, M. K., . . . Scott, H. S. (2016). Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. Blood, 127(8), 1017-1023. DOI Scopus132 WoS122 Europe PMC79
2016	Ling, K., Brautigan, P., Moore, S., Fraser, R., Cheah, P., Raison, J., . . . Scott, H. (2016). Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain. Genomics, 107(2-3), 88-99. DOI Scopus14 WoS12 Europe PMC9
2016	Ling, K., Brautigan, P., Moore, S., Fraser, R., Leong, M., Leong, J., . . . Scott, H. (2016). In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts. Data in Brief, 7, 282-290. DOI Scopus4 Europe PMC2
2015	Gagliardi, L., Nataren, N., Feng, J., Schreiber, A., Hahn, C., Conwell, L., . . . Scott, H. (2015). Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss. American Journal of Medical Genetics, Part A, 167(8), 1872-1876. DOI Scopus8 WoS8 Europe PMC4
2015	Hu, Z., Scott, H., Qin, G., Zheng, G., Chu, X., Xie, L., . . . Wei, C. (2015). Revealing missing human protein isoforms based on ab initio prediction, RNA-seq and proteomics. Scientific Reports, 5(1), 10940-1-10940-15. DOI Scopus26 WoS23 Europe PMC14
2015	Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994. DOI Scopus136 WoS127 Europe PMC82
2015	Hahn, C., Venugopal, P., Scott, H., & Hiwase, D. (2015). Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy. Immunological Reviews, 263(1), 257-278. DOI Scopus33 WoS30 Europe PMC25
2015	Hahn, C., Brautigan, P., Chong, C., Janssan, A., Venugopal, P., Lee, Y., . . . Scott, H. (2015). Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia. Leukemia, 29(8), 1795-1797. DOI Scopus9 WoS9 Europe PMC8
2015	Hahn, C., Ross, D., Feng, J., Beligaswatte, A., Hiwase, D., Parker, W., . . . Scott, H. (2015). A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia, 29(10), 2101-2104. DOI Scopus23 WoS22 Europe PMC20
2014	Hiwase, D. K., Hahn, C. N., Babic, M., Moore, S., Butcher, C. M., Kutyna, M. M., . . . Scott, H. S. (2014). Clonal Diversity of Recurrently Mutated Genes in Myelodysplastic Syndromes. BLOOD, 124(21), 3 pages.
2014	Gagliardi, L., Schreiber, A., Hahn, C., Feng, J., Cranston, T., Boon, H., . . . Scott, H. (2014). ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 99(9), E1784-E1792. DOI Scopus80 WoS69 Europe PMC46
2014	Young, J. A., Ting, K. K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. R. (2014). Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919)). Blood, 124(19), 3034. DOI
2013	Shah, S., & Hahn, C. (2013). A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nature Genetics, 45(10), 1226-1231. DOI Scopus210 WoS187 Europe PMC136
2013	Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. (2013). Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. DOI Scopus50 WoS48 Europe PMC35
2012	Gagliardi, L., Ling, K., Kok, C., Carolan, J., Brautigan, P., Kenyon, R., . . . Scott, H. (2012). Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia. Endocrine-Related Cancer, 19(3), 19-23. DOI Scopus5 WoS6 Europe PMC3
2012	Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291. DOI Scopus203 WoS187 Europe PMC138
2012	Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., . . . Gecz, J. (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115. DOI Scopus71 WoS69 Europe PMC55
2012	Hahn, C., & Scott, H. (2012). Spliceosome mutations in hematopoietic malignancies. Nature Genetics, 44(1), 9-10. DOI Scopus49 WoS44 Europe PMC37
2011	Hahn, C., Chong, C., Carmichael, C., Wilkins, E., Brautigan, P., Li, X., . . . Scott, H. (2011). Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nature Genetics, 43(10), 1012-1019. DOI Scopus429 WoS398 Europe PMC292
2011	Ling, K., Brautigan, P., Hahn, C., Daish, T., Rayner, J., Cheah, P., . . . Scott, H. (2011). Deep sequencing analysis of the developing mouse brain reveals a novel microRNA. BMC Genomics, 12(1), 1-15. DOI Scopus49 WoS43 Europe PMC33
2011	Ling, K., Hewitt, C., Beissbarth, T., Hyde, L., Cheah, P., Smyth, G., . . . Scott, H. (2011). Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cerebral Cortex, 21(3), 683-697. DOI Scopus29 WoS26 Europe PMC21
2010	Carmichael, C., Wilkins, E., Bengtsson, H., Horwitz, M., Speed, T., Vincent, P., . . . Scott, H. (2010). Poor prognosis in familial acute myeloid leukaemia with combined biallelic CEBPA mutations and downstream events affecting the ATM, FLT3 and CDX2 genes. British Journal of Haematology, 150(3), 382-385. DOI Scopus14 WoS11 Europe PMC9
2010	Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., . . . Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. DOI Scopus39 WoS36 Europe PMC35
2010	Jongmans, M., Kuiper, R., Carmichael, C., Wilkins, E., Dors, N., Carmagnac, A., . . . Hoogerbrugge, N. (2010). Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome. Leukemia, 24(1), 242-246. DOI Scopus70 WoS68 Europe PMC45
2009	Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., & Bonder, C. (2009). Sphingosine kinase-1 associates with Integrin alpha(V)beta(3) to mediate endothelial cell survival. American Journal of Pathology, 175(5), 2217-2225. DOI Scopus17 WoS14 Europe PMC13
2009	Ling, K., Hewitt, C., Beissbarth, T., Hyde, L., Ghosal, K., Cheah, P., . . . Scott, H. (2009). Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biology (Online Edition), 10(10), 1-31. DOI Scopus35 WoS31 Europe PMC27
2009	Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., . . . Gamble, J. (2009). JAM-C Induces endothelial cell permeability through its association and regulation of beta(3) integrins. Arteriosclerosis Thrombosis and Vascular Biology, 29(8), 1200-U101. DOI Scopus38 WoS34 Europe PMC30
2009	Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., & Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular & Molecular Biology Letters, 14(3), 424-441. DOI Scopus29 WoS22 Europe PMC13
2008	Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., . . . Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497. DOI Scopus74 WoS68 Europe PMC53
2006	Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., . . . Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067. DOI Scopus78 WoS78 Europe PMC51
2006	Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., & Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. DOI Scopus75 WoS63 Europe PMC34
2005	Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., & Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. DOI Scopus145 WoS141 Europe PMC108
2005	Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., . . . Gamble, J. (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(1), 57-69. DOI Scopus17 WoS15 Europe PMC14
2004	Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., . . . Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 12212-12217. DOI Scopus37 WoS34 Europe PMC33
2004	Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., . . . Xia, P. (2004). PPARg agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: Role of diacylglycerol kinase. Circulation Research, 94(11), 1515-1522. DOI Scopus93 WoS87 Europe PMC74
2004	Hime, N., Drew, K., Hahn, C., Barter, P., & Rye, K. (2004). Apolipoprotein E enhances hepatic lipase-mediated hydrolysis of reconstituted high-density lipoprotein phospholipid and triacylglycerol in an isoform-dependent manner. Biochemistry, 43(38), 12306-12314. DOI Scopus20 WoS21 Europe PMC15
2004	Li, X., Hahn, C. N., Parsons, M., Drew, J., Vadas, M. A., & Gamble, J. R. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: Inhibition by angiopoietin-1. Blood, 104(6), 1716-1724. DOI Scopus60 WoS57 Europe PMC50
2004	Nastasi, T., Bongiovanni, A., Campos, Y., Mann, L., Toy, J. N., Bostrom, J., . . . d'Azzo, A. (2004). Ozz-E3, a muscle-specific ubiquitin ligase, regulates β-catenin degradation during myogenesis. Developmental Cell, 6(2), 269-282. DOI Scopus76 WoS71 Europe PMC61
2003	Hime, N., Wee, K., Barter, P., & Rye, K. -A. (2003). 3P-0731 In vivo formation of high density lipoproteins containing both apolipoprotein A-I and apolipoprotein A-II in the rabbit. Atherosclerosis Supplements, 4(2), 222. DOI
2002	De Geest, N., Bonten, E., Mann, L., De Sousa-Hitzler, J., Hahn, C., & D'Azzo, A. (2002). Genotype-phenotype correlation in inherited severe insulin resistance. Human Molecular Genetics, 11(12), 1465-1475. DOI Scopus136 Europe PMC76
2002	de Geest, N., Bonten, E., Mann, L., de Souza-Hitzler, J., Hahn, C., & d'Azzo, A. (2002). Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice. HUMAN MOLECULAR GENETICS, 11(12), 1455-1464. DOI WoS82 Europe PMC55
2000	Davey, R., Hahn, C., May, B., & Morris, H. (2000). Osteoblast gene expression in rat long bones: Effects of ovariectomy and dihydrotestosterone on mRNA levels. Calcified Tissue International, 67(1), 75-79. DOI Scopus33 WoS33 Europe PMC21
1998	Rottier, R. J., Hahn, C. N., Mann, L. W., Del Pilar Martin, M., Smeyne, R. J., Suzuki, K., & D'Azzo, A. (1998). Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: Indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. Human Molecular Genetics, 7(11), 1787-1794. DOI Scopus22 WoS20 Europe PMC13
1998	Hahn, C. N., Del Pilar Martin, M., Zhou, X. Y., Mann, L. W., & D'Azzo, A. (1998). Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin a under control of the colony-stimulating factor-1 receptor promoter. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14880-14885. DOI Scopus43 WoS45 Europe PMC23
1997	Hahn, C. N., Del Pilar Martin, M., Schröder, M., Vanier, M. T., Hara, Y., Suzuki, K., . . . D'Azzo, A. (1997). Generalized CNS disease and massive G(M1)-ganglioside accumulation in mice defective in lysosomal acid β-galactosidase. Human Molecular Genetics, 6(2), 205-211. DOI Scopus131 WoS119 Europe PMC91
1996	Kerry, D., Dwivedi, P., Morris, H., Omdahl, J., & May, B. (1996). Transcriptional Sygernism Between Vitamin D-Rsponsive Elements in the Rat 25-Hyroxyvitamin D-3 24-Hydroxylase (CYP24) Promotor. Journal of Biological Chemistry, 271(47), 29715-29721. DOI Scopus111 WoS101 Europe PMC65
1994	Hahn, C. N., Kerry, D. M., Omdahl, J. L., & May, B. K. (1994). Identification of a vitamin D responsive element in the promoter of the rat cytochrome P450<inf>24</inf> gene. Nucleic Acids Research, 22(12), 2410-2416. DOI Scopus64 WoS58 Europe PMC21
1993	HAHN, C. N., KERRY, D. M., MAY, B. K., & OMDAHL, J. L. (1993). CHARACTERIZATION OF THE PROMOTER REGION FOR THE RAT CYTOCHROME P-45024 GENE(CYP24). JOURNAL OF BONE AND MINERAL RESEARCH, 8, S126.
1993	Dogra, S. C., Hahn, C. N., & May, B. K. (1993). Superinduction by Cycloheximide of Cytochrome P4502H1 and 5-Aminolevulinate Synthase Gene Transcription in Chick Embryo Liver. Archives of Biochemistry and Biophysics, 300(1), 531-534. DOI Scopus19 WoS22 Europe PMC9
1993	Hahn, C. N., Baker, E., Laslo, P., May, B. K., Omdahl, J. L., & Sutherland, G. R. (1993). Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20ql3.2→ql3.3. Cytogenetic and Genome Research, 62(4), 192-193. DOI Scopus24 WoS17 Europe PMC7
1991	Hahn, C. N., Hansen, A. J., & May, B. K. (1991). Transcriptional regulation of the chicken CYP2H1 gene: Localization of a phenobarbital-responsive enhancer domain. Journal of Biological Chemistry, 266(26), 17031-17039. DOI Scopus43 WoS48 Europe PMC17

Conference Papers

Year	Citation
2021	Hahn, C. N., Feurstein, S. K., Singhal, D., Kutyna, M. M., Chhetri, R., Wee, A., . . . Hiwase, D. (2021). Unexpected High Frequency of Pathogenic Germline Variants in Older Adults with Primary Myelodysplastic Syndrome. In BLOOD Vol. 138 (pp. 4 pages). AMER SOC HEMATOLOGY. DOI WoS1
2019	Homan, C., Armstrong, M., Dobbins, J., Lawrence, D., Wang, P., Arts, P., . . . Brown, A. (2019). DEVELOPMENT OF A DATA PORTAL FOR AGGREGATION AND ANALYSIS OF GENOMICS DATA IN FAMILIAL PLATELET DISORDER WITH PREDISPOSITION TO MYELOID MALIGNANCY - THE RUNX1.DB. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S69). ELSEVIER SCIENCE INC.
2019	Venugopal, P., Babic, M., Barnett, C., Bray, S., Brown, A., Cheah, J., . . . Young, C. C. (2019). IMPLICATIONS OF REVERTANT SOMATIC MOSAICISM IN BONE MARROW FAILURE SYNDROMES. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S90). ELSEVIER SCIENCE INC.
2019	Cheah, J., Brown, A., Eshraghi, L., Feng, J., Schreiber, A., Babic, M., . . . Scott, H. (2019). AN INTEGRATIVE GENOMIC APPROACH TO EXAMINE MUTATIONS AND BIOLOGICAL PATHWAYS ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCY DEVELOPMENT IN DDX41 MUTATED FAMILIES. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S61). ELSEVIER SCIENCE INC.
2019	Singhal, D., Hahn, C. N., Moma, L. D., Wee, L. Y. A., Chhetri, R., Babic, M., . . . Hiwase, D. K. (2019). Deleterious Germline Variants, Especially in the DNA Repair Pathway, Are Common in Patients with Non-Related Multiple Cancers, One of Them Being Hematological Malignancy. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS1
2019	Venugopal, P., Cheah, J. J. C., Eshraghi, L., Shahrin, N. H., Homan, C., Feng, J., . . . Scott, H. S. (2019). An Integrative Genomic Approach to Examine Mutations and Biological Pathways Associated with Hematological Malignancy Development in DDX41 Mutated Families. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS2
2019	Brown, A. L., Babic, M., Schreiber, A., Feng, J., Dobbins, J., Arts, P., . . . Scott, H. S. (2019). Familial Clustering of Hematological Malignancies: Harbingers of Wider Germline Cancer Susceptibility. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS1
2019	Hahn, C. N., Babic, M., Brautigan, P. J., Venugopal, P., Phillips, K., Dobbins, J., . . . Scott, H. S. (2019). Australian Familial Haematological Cancer Study - Findings from 15 Years of Aggregated Clinical, Genomic and Transcriptomic Data. In BLOOD Vol. 134 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS1
2017	Singhal, D., Wee, A., Parker, W., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2017). Presence of Rare Germline Variants in Fanconi Anaemia Pathway Genes Confers a Poor Prognosis Comparable to TP53 Mutations in Therapy-Related Myeloid Neoplasms. In BLOOD Vol. 130 (pp. 3 pages). Atlanta, GA: AMER SOC HEMATOLOGY. WoS1
2017	Branford, S., Wang, P., Yeung, D., Purins, A., Marum, J. E., Nataren, N., . . . Hughes, T. P. (2017). Integrative Genomics Reveals Cancer Associated Mutations Are Common at Diagnosis of CML in Patients with Poor Response to TKI Therapy. In BLOOD Vol. 130 (pp. 4 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
2017	Hahn, C. N., Wee, A., Babic, M., Feng, J., Wang, P., Kutyna, M. M., . . . Scott, H. S. (2017). Duplication on Chromosome 14q Identified in Familial Predisposition to Myeloid Malignancies and Myeloproliferative Neoplasms. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY. WoS1
2016	Singhal, D., Wee, L. A., Parker, W. T., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2016). The Frequency of Genetic Mutations in T-MN Is High and Comparable to Primary MDS but the Spectrum Is Different. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI
2016	Bassal, M. A., Leo, P., Samaraweera, S. E., Maung, K. Z. Y., Babic, M., Venugopal, P., . . . D'Andrea, R. (2016). Metabolic Profiling of Adult Acute Myeloid Leukemia (AML). In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI WoS1
2016	Brown, A. L., Hahn, C. N., Carmichael, C., Wilkins, E., Babic, M., Chong, C. -E., . . . Scott, H. S. (2016). Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline RUNX1 Mutations. In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY. DOI
2015	Hahn, C. N., Babic, M., Schreiber, A. W., Kutyna, M. M., Wee, L. A., Brown, A. L., . . . Hiwase, D. (2015). Rare and Common Germline Variants Contribute to Occurrence of Myelodysplastic Syndrome. In BLOOD Vol. 126 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY. DOI WoS2
2015	Branford, S., Wang, P. P. S., Parker, W. T., Yeung, D., Marum, J. E., Stangl, D., . . . Hughes, T. P. (2015). High Incidence of Mutated Cancer-Associated Genes at Diagnosis in CML Patients with Early Transformation to Blast Crisis. In BLOOD Vol. 126 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY.
2014	Ling, K., Lee, H., Brautigan, P., Moore, S., Fraser, R., Cheah, P., . . . Scott, H. (2014). Deciphering the secret role of Sox4 gene locus during mouse cerebral corticogenesis. In Journal of Neurochemistry Vol. 130 (pp. 8). Kaohsiung, Taiwan: Wiley.
2014	Casolari, D. A., Iarossi, D. G., Butcher, C. M., Bray, S. C., Parker, W. T., Hahn, C. N., . . . D'Andrea, R. J. (2014). Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib. In BLOOD Vol. 124 (pp. 3 pages). San Francisco, CA: AMER SOC HEMATOLOGY.
2011	Rao, N., Butcher, C., Neufing, P., Bray, S., Hahn, C., Scott, H., . . . D'Andrea, R. (2011). Mechanisms of Co-operation of DNMT3A Mutations with JAK2 V617F Through Histone H4 Arginine 3 Provides New Insights in MPN Disease Pathogenesis. In 53rd ASH Annual Meeting and Exposition Vol. 118 (pp. 1). Washington DC: AMER SOC HEMATOLOGY.
2003	Hime, N., Wee, K., Barter, P., & Rye, K. A. (2003). In vivo formation of high density lipoproteins containing both apolipoprotein A-I and apolipoprotein A-II in the rabbit. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 4 (pp. 222). KYOTO, JAPAN: ELSEVIER IRELAND LTD.
2003	Hime, N., Drew, K., Hahn, C., & Rye, K. A. (2003). Influence of apolipoprotein E isoforms on hepatic lipase-mediated phospholipid and triacylglycerol hydrolysis in reconstituted high density lipoproteins. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 4 (pp. 222). KYOTO, JAPAN: ELSEVIER IRELAND LTD.
1999	De Geest, N., Mann, L., De Sousa-Hitzler, J., Hahn, C., Rottier, R., & D'Azzo, A. (1999). Lysosomal neuraminidase deficiency in mice: a model for sialidosis.. In AMERICAN JOURNAL OF HUMAN GENETICS Vol. 65 (pp. A26). UNIV CHICAGO PRESS. WoS1

Conference Items

Year	Citation
2018	Singhal, D., Wee, A., Kutyna, M. M., Babic, M., Chhetri, R., Parker, W., . . . Hiwase, D. K. (2018). Therapy-Related Myeloid Neoplasms (T-MN) and Primary MDS (PMDS) Patients with Very Low (VL) or Low (L) IPSS-R Score Share Clinical and Biological Characteristics and Have Similar Outcome. Poster session presented at the meeting of BLOOD. San Diego, CA: AMER SOC HEMATOLOGY. DOI
2017	Oftedal, B. E., Lundgren, B. A., Bratland, E., Wolff, A. B., Hamm, D., Gan, P. -Y., . . . Scott, H. S. (2017). T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Poster session presented at the meeting of SCANDINAVIAN JOURNAL OF IMMUNOLOGY. Stockholm, SWEDEN: WILEY.
2017	Singhal, D., Wee, L. A., Babic, M., Parker, W., Moore, S., Feng, J., . . . Hiwase, D. (2017). THERAPY RELATED MYELOID NEOPLASMS (T-MN) SHOW HIGH MUTATION FREQUENCY AND A SPECTRUM DIFFERENT FROM PRIMARY MDS. Poster session presented at the meeting of LEUKEMIA RESEARCH. Valencia, SPAIN: PERGAMON-ELSEVIER SCIENCE LTD. DOI
2017	De Sousa, S. M. C., Stowasser, M., Feng, J., Schreiber, A. W., Hahn, C. N., Torpy, D. J., . . . Scott, H. S. (2017). Sequence variants in ARMC5 are not implicated in familial hyperaldosteronism type II. Poster session presented at the meeting of CLINICAL ENDOCRINOLOGY. WILEY-BLACKWELL.
2016	Beck, D., Thoms, J., Palu, C., Herold, T., Shah, A., Olivier, J., . . . Pimanda, J. (2016). INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES. Poster session presented at the meeting of HAEMATOLOGICA. Copenhagen, DENMARK: FERRATA STORTI FOUNDATION.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2022	Co-Supervisor	Investigation of germline ERG mutations associated with predisposition to haematological malignancies.	Doctor of Philosophy	Doctorate	Full Time	Ms Jiarna Rose Zerella

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2012 - 2016	Co-Supervisor	Identification and Characterisation of Genetic Lesions that Predispose to and Gene Expression Patterns that Contribute to Myeloid Malignancies	Doctor of Philosophy	Doctorate	Full Time	Ms Parvathy Venugopal
2009 - 2013	Co-Supervisor	Genetics and Functional Characterization of GATA2, a Novel Cancer Gene in Familial Leukaemia	Doctor of Philosophy	Doctorate	Full Time	Mr Chan Eng Chong
2000 - 2005	Co-Supervisor	Characterisation of a novel gene p73RhoGAP in angiogenesis	Doctor of Philosophy	Doctorate	Full Time	Mrs Zhi Su

Email: christopher.hahn@adelaide.edu.au

Christopher Hahn

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Current Higher Degree by Research Supervision (University of Adelaide)

Past Higher Degree by Research Supervision (University of Adelaide)

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