Christopher Hahn
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Christopher N Hahn, PhD
SA Pathology Department of Genetics and Molecular Pathology Frome Rd, Adelaide.
Molecular Pathology Research Laboratory:
All disease processes in humans have a genetic component, either inherited or acquired by somatic mutation during cell division. It is important to identify genes and mutations that cause disease, predispose families to diseases, or are acquired during disease progression as these are important diagnostic and prognostic markers. They also provide direct targets and biological pathways for therapeutic intervention.
We are interested in how and why genetic mutations occur, how these changes cause diseases or disease predisposition such as cancer and autoimmunity, and ways of better treating and monitoring these diseases. Our model diseases are typically, blood cell diseases, such as leukaemias, lymphomas and autoimmunity (such as arthritis). We also work on rare or orphan diseases with unmet clinical needs, such as genetic diagnoses for family planning.
Our department is co-located with the ACRF Cancer Genomics Facility, which provides access to powerful cutting edge genetic/genomic technologies including bioinformatics, next-generation sequencing and sample preparation robotics. The Department performs both basic and translational research, which includes implementing these new technologies into its diagnostic tests for personalized medicine.
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Appointments
Date Position Institution name 2020 - ongoing Adjunct Associate Professor University of South Australia 2019 - ongoing Affiliate Senior Lecturer University of Adelaide 2018 - ongoing Associate Member of the Centre for Cancer Biology Faculty Centre for Cancer Biology 2008 - ongoing Section Head - Molecular Pathology Research Laboratory SA Pathology -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 1987 - 1991 University of Adelaide Australia PhD -
Research Interests
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Journals
Year Citation 2024 Hong, L. E., Wechalekar, M. D., Kutyna, M., Small, A., Lim, K., Thompson-Peach, C., . . . Hiwase, D. K. (2024). IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation. Blood, blood.2023023593.
2024 Kan, W. L., McClure, B. J., Hahn, C. N., & Powell, J. A. (2024). The 10<sup>th</sup> Barossa meeting: Cell Signalling to Cancer Medicine. Cell Death and Disease, 15(3), 3 pages.
2023 Hiwase, D. K., Hahn, C. N., Tran, E. N. H., Chhetri, R., Baranwal, A., Al-Kali, A., . . . Shah, M. V. (2023). TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype. Blood, 141(9), 1087-1091.
Scopus9 WoS7 Europe PMC62023 Beland, B., Hahn, C., Jamani, K., Chhibber, S., White, C., Atkins, H., & Storek, J. (2023). Autologous hematopoietic stem cell transplant for the treatment of refractory myasthenia gravis with anti-muscle specific kinase antibodies. MUSCLE & NERVE, 67(2), 154-157.
WoS32023 Samaraweera, S. E., Geukens, T., Casolari, D. A., Nguyen, T., Sun, C., Bailey, S., . . . Ross, D. M. (2023). Novel modes of MPL activation in triple-negative myeloproliferative neoplasms. Pathology, 55(1), 77-85.
2023 Saygin, C., Roloff, G. W., Hahn, C. N., Chhetri, R., Gill, S. I., Elmariah, H., . . . Godley, L. A. (2023). Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies. Blood Advances, 7(4), 549-554.
Scopus21 WoS10 Europe PMC112023 Flerlage, J. E., Myers, J. R., Maciaszek, J. L., Oak, N., Rashkin, S. R., Hui, Y., . . . Rampersaud, E. (2023). Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma. Blood, 141(11), 1293-1307.
Scopus7 WoS4 Europe PMC52023 Shah, M. V., Tran, E. N. H., Shah, S., Chhetri, R., Baranwal, A., Ladon, D., . . . Hiwase, D. K. (2023). TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms. Blood Cancer Journal, 13(1), 51-1-51-9.
Scopus5 WoS2 Europe PMC42023 Walters, K., Federico, P., & Hahn, C. (2023). Auditory Agnosia in Autoimmune Encephalitis. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 50(5), 784-786.
2023 Zerella, J. R., Homan, C. C., Arts, P., Brown, A. L., Scott, H. S., & Hahn, C. N. (2023). Transcription factor genetics and biology in predisposition to bone marrow failure and hematological malignancy. Frontiers in Oncology, 13, 1-33.
2023 Homan, C. C., Drazer, M. W., Yu, K., Lawrence, D. M., Feng, J., Arriola-Martinez, L., . . . Brown, A. L. (2023). Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Advances, 7(20), 6092-6107.
Scopus8 Europe PMC62023 Elzinga, K., Khayambashi, S., Hahn, C., Mahe, E., & Fine, N. M. (2023). Amyloidosis and Carpal Tunnel Syndrome: Surgical Technique for Extended Carpal Tunnel Release with Tenosynovium and Transverse Carpal Ligament Biopsies. PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN, 11(1), 8 pages.
WoS12022 Zhu, Y., Heo, T. W., Rodriguez, J. N., Weber, P. K., Shi, R., Baer, B. J., . . . Wood, B. C. (2022). Hydriding of titanium: Recent trends and perspectives in advanced characterization and multiscale modeling. CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, 26(6), 24 pages.
WoS72022 Lewis, E., Fine, N., Miller, R. J. H., Hahn, C., Chhibber, S., Mahe, E., . . . Jimenez-Zepeda, V. H. (2022). Amyloidosis and COVID-19: experience from an amyloid program in Canada. ANNALS OF HEMATOLOGY, 101(10), 2307-2315.
WoS62022 Lee, A., Fine, N. M., Bril, V., Delgado, D., & Hahn, C. (2022). Hereditary transthyretin amyloidosis: a case report. JOURNAL OF MEDICAL CASE REPORTS, 16(1), 5 pages.
WoS22022 Wan, M. M., Lee, A., Kapadia, R., & Hahn, C. (2022). Case Series of Guillain-Barre Syndrome After the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) Vaccine. NEUROLOGY-CLINICAL PRACTICE, 12(2), 149-153.
WoS22022 Roberts, J., Hahn, C., & Metz, L. M. (2022). Multiple Sclerosis Clinic Utilization is Associated with Fewer Emergency Department Visits. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 49(3), 393-397.
WoS12022 Wadhwa, A., Hahn, C., Fifi-Mah, A., & Almekhlafi, M. (2022). Utility of Vessel Wall Imaging in Suspected CNS Vasculitis with Normal Routine Workup. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 49(2), 291-293.
2022 Horak, T., Coenen, N., Metzger, N., Hahn, C., Flemisch, T., Mendez, J., . . . Dachselt, R. (2022). Visual Analysis of Hyperproperties for Understanding Model Checking Results. IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS, 28(1), 357-367.
WoS22022 Alcantara, M., Mezei, M. M., Baker, S. K., Breiner, A., Dhawan, P., Fiander, A., . . . Bril, V. (2022). Canadian Guidelines for Hereditary Transthyretin Amyloidosis Polyneuropathy Management. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 49(1), 7-18.
WoS42022 Baranwal, A., Hahn, C. N., Shah, M. V., & Hiwase, D. K. (2022). Role of Germline Predisposition to Therapy-Related Myeloid Neoplasms. Current Hematologic Malignancy Reports, 17(6), 254-265.
Scopus7 WoS3 Europe PMC62022 Feurstein, S., Luo, X., Shah, M., Walker, T., Mehta, N., Wu, D., . . . Zhang, L. (2022). Revision of RUNX1 variant curation rules. Blood Advances, 6(16), 4726-4730.
Scopus6 WoS2 Europe PMC52022 Shah, M., Hahn, C. N., Tran, E. N. H., Sharplin, K. M., Chhetri, R., Baranwal, A., . . . Hiwase, D. (2022). <i>TP53</i> Mutation Status Defines a Distinct Clinicopathological Entity of Therapy-Related Myeloid Neoplasm, Characterized By Genomic Instability and Extremely Poor Outcome. BLOOD, 140(Supplement 1), 9798-9799.
2022 Feurstein, S., Hahn, C. N., Mehta, N., & Godley, L. A. (2022). A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias. Genetics in Medicine, 24(4), 931-954.
Scopus6 WoS3 Europe PMC62022 Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15.
Scopus14 WoS7 Europe PMC62022 Drazer, M. W., Homan, C. C., Yu, K., Cavalcante de Andrade Silva, M., McNeely, K. E., Pozsgai, M. J., . . . Godley, L. A. (2022). Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.. Blood Adv, 6(15), 4357-4359.
Scopus12 WoS4 Europe PMC72021 Singhal, D., Hahn, C. N., Feurstein, S., Wee, L. Y. A., Moma, L., Kutyna, M. M., . . . Hiwase, D. K. (2021). Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer. Leukemia, 35(11), 3245-3256.
Scopus34 WoS26 Europe PMC252021 Homan, C. C., King-Smith, S. L., Lawrence, D. M., Arts, P., Feng, J., Andrews, J., . . . Brown, A. L. (2021). The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.. Haematologica, 106(11), 3004-3007.
Scopus27 WoS20 Europe PMC132021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). GATA2 deficiency syndrome: a decade of discovery. Human Mutation, 42(11), 1399-1421.
Scopus24 WoS13 Europe PMC202021 Samaraweera, S. E., Wang, P. P. S., Li, K. L., Casolari, D. A., Feng, J., Pinese, M., . . . D'Andrea, R. J. (2021). Childhood acute myeloid leukemia shows a high level of germline predisposition. Blood, 138(22), 2293-2298.
Scopus5 WoS5 Europe PMC52021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). Cover, Volume 42, Issue 11. Human Mutation, 42(11).
2021 Russell, A., Hahn, C., Chhibber, S., Korngut, L., & Fine, N. M. (2021). Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 48(5), 607-615.
WoS92021 Hansen, M., Arnold, A. J., & Hahn, C. (2021). NF-155 IgG in Acute-onset Inflammatory Neuropathy: Two Cases with Relapses and Recovery. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 48(3), 443-445.
2021 Drazer, M. W., Homan, C. C., Yu, K., de Andrade Silva, M. C., McNeely, K. E., Pozsgai, M. J., . . . Godley, L. A. (2021). Clonal hematopoiesis in individuals with <i>ANKRD26</i> or <i>ETV6</i> germline mutations.
2020 Sumner, B., Bonadio, W., & Hahn, C. (2020). Hepatic Portal Venous Gas Incidentally Associated With Bacterial Enteritis: A Case Report. CUREUS JOURNAL OF MEDICAL SCIENCE, 12(9), 5 pages.
2020 Krett, J. D., Jewett, G. A. E., Elton-Lacasse, C., Fonseca, K., Hahn, C., Au, S., & Koch, M. W. (2020). Hemorrhagic encephalopathy associated with COVID-19. JOURNAL OF NEUROIMMUNOLOGY, 346, 4 pages.
WoS172020 Woodward, K. E., Shah, R. M., Benseler, S., Wei, X. -C., Ng, D., Grossman, J., . . . Appendino, J. P. (2020). Considering immunologic and genetic evaluation for HLH in neuroinflammation: A case of Griscelli syndrome type 2 with neurological symptoms and a lack of albinism. PEDIATRIC BLOOD & CANCER, 67(8), 3 pages.
WoS72020 Au, K. L. K., Latonas, S., Shameli, A., Auer, I., & Hahn, C. (2020). Cerebrospinal Fluid Flow Cytometry: Utility in Central Nervous System Lymphoma Diagnosis. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 47(3), 382-388.
WoS52020 Finkbeiner, B., Hahn, C., Lukert, P., Stenger, M., & Tentrup, L. (2020). Synthesis from hyperproperties. ACTA INFORMATICA, 57(1-2), 137-163.
WoS82020 Fine, N. M., Davis, M. K., Anderson, K., Delgado, D. H., Giraldeau, G., Kitchlu, A., . . . Zieroth, S. (2020). Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis. CANADIAN JOURNAL OF CARDIOLOGY, 36(3), 322-334.
WoS452020 Finkbeiner, B., Hahn, C., Stenger, M., & Tentrup, L. (2020). Efficient monitoring of hyperproperties using prefix trees. INTERNATIONAL JOURNAL ON SOFTWARE TOOLS FOR TECHNOLOGY TRANSFER, 22(6), 729-740.
WoS22020 Venugopal, P., Gagliardi, L., Forsyth, C., Feng, J., Phillips, K., Babic, M., . . . Scott, H. S. (2020). Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss. BMC Medical Genetics, 21(1), 35-1-35-5.
Scopus3 WoS2 Europe PMC22020 Brown, A. L., Arts, P., Carmichael, C. L., Babic, M., Dobbins, J., Chong, C. -E., . . . Scott, H. S. (2020). RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Advances, 4(6), 1131-1144.
Scopus89 WoS65 Europe PMC572020 Brown, A. L., Hahn, C. N., & Scott, H. S. (2020). Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA). Blood, 136(1), 24-35.
Scopus63 WoS49 Europe PMC502020 Fox, L. C., Tan, M., Brown, A. L., Arts, P., Thompson, E., Ryland, G. L., . . . Blombery, P. (2020). A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability. British Journal of Haematology, 190(5), e297-e301.
Scopus12 WoS12 Europe PMC92020 Brown, A. L., Hahn, C., Hiwase, D., Godley, L. A., & Scott, H. S. (2020). Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis. LEUKEMIA & LYMPHOMA, 61(1), 2 pages.
Scopus2 WoS2 Europe PMC12020 Bohus, M., Kleindienst, N., Hahn, C., Mueller-Engelmann, M., Ludaescher, P., Steil, R., . . . Priebe, K. (2020). Dialectical Behavior Therapy for Posttraumatic Stress Disorder (DBT-PTSD) Compared With Cognitive Processing Therapy (CPT) in Complex Presentations of PTSD in Women Survivors of Childhood Abuse: A Randomized Clinical Trial. JAMA PSYCHIATRY, 77(12), 1235-1245.
WoS672019 Finkbeiner, B., Hahn, C., Stenger, M., & Tentrup, L. (2019). Monitoring hyperproperties. FORMAL METHODS IN SYSTEM DESIGN, 54(3), 336-363.
WoS202019 Byrne, A. B., Arts, P., Polyak, S. W., Feng, J., Schreiber, A. W., Kassahn, K. S., . . . Scott, H. S. (2019). Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6. npj Genomic Medicine, 4(1), 1-8.
Scopus17 WoS11 Europe PMC102019 Cheah, J. J. C., Brown, A. L., Schreiber, A. W., Feng, J., Babic, M., Moore, S., . . . Scott, H. S. (2019). A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia. Haematologica, 104(7), e318-e321.
Scopus13 WoS12 Europe PMC112019 Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., . . . Mullighan, C. G. (2019). Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nature genetics, 51(4), 694-704.
Scopus93 WoS68 Europe PMC672019 Singhal, D., Wee, L. Y. A., Kutyna, M. M., Chhetri, R., Geoghegan, J., Schreiber, A. W., . . . Hiwase, D. K. (2019). The mutational burden of therapy-related myeloid neoplasms is similar to primary myelodysplastic syndrome but has a distinctive distribution. Leukemia, 33(12), 2842-2853.
Scopus41 WoS38 Europe PMC252018 Al Seraihi, A. F., Rio-Machin, A., Tawana, K., Bödör, C., Wang, J., Nagano, A., . . . Fitzgibbon, J. (2018). GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML. Leukemia, 32(11), 2502-2507.
Scopus46 WoS40 Europe PMC372018 Branford, S., Wang, P., Yeung, D. T., Thomson, D., Purins, A., Wadham, C., . . . Hughes, T. P. (2018). Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease. Blood, 132(9), 948-961.
Scopus136 WoS121 Europe PMC952018 Beck, D., Thoms, J., Palu, C., Herold, T., Shah, A., Olivier, J., . . . Pimanda, J. (2018). A four-gene lincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients. Leukemia, 32(2), 263-272.
Scopus33 WoS30 Europe PMC192018 Chong, C. -E., Venugopal, P., Stokes, P., Lee, Y., Brautigan, P., Yeung, D., . . . Scott, H. (2018). Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes. Leukemia, 32(1), 194-202.
Scopus45 WoS40 Europe PMC302017 Carruthers, V., Nicola, M., Venugopal, P., Hahn, C. N., Scott, H. S., & Revesz, T. (2017). Clinical implications of transient myeloproliferative disorder in a neonate without Down syndrome features. Journal of Paediatrics and Child Health, 53(10), 1018-1020.
Scopus1 WoS1 Europe PMC12017 Pagani, I. S., Kok, C. H., Saunders, V. A., Van der Hoek, M. B., Heatley, S. L., Schwarer, A. P., . . . Ross, D. M. (2017). A method for next-generation sequencing of paired diagnostic and remission Samples to detect mitochondrial DNA mutations associated with leukemia. The Journal of molecular diagnostics : JMD, 19(5), 711-721.
Scopus6 WoS5 Europe PMC52017 Oftedal, B., Ardesjö Lundgren, B., Hamm, D., Gan, P., Holdsworth, S., Hahn, C., . . . Scott, H. (2017). T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Journal of Autoimmunity, 81, 1-10.
Scopus7 WoS6 Europe PMC22017 Casolari, D., Nguyen, T., Butcher, C., Iarossi, D., Hahn, C., Bray, S., . . . D'Andrea, R. (2017). A novel, somatic, transforming mutation in the extracellular domain of epidermal growth factor receptor identified in myeloproliferative neoplasm. Scientific Reports, 7(1), 2467-1-2467-9.
Scopus6 WoS5 Europe PMC52017 Cheah, J., Hahn, C., Hiwase, D., Scott, H., & Brown, A. (2017). Myeloid neoplasms with germline DDX41 mutation. International Journal of Hematology, 106(2), 163-174.
Scopus72 WoS59 Europe PMC522017 Tiong, I., Casolari, D., Moore, S., Nguyen, T., Van Velzen, M., Zantomio, D., . . . Ross, D. (2017). Apparent ‘JAK2-negative’ polycythaemia vera due to compound mutations in exon 14. British Journal of Haematology, 178(2), 333-336.
Scopus12 WoS10 Europe PMC62017 Venugopal, P., Moore, S., Lawrence, D., George, A., Hannan, R., Bray, S., . . . Scott, H. (2017). Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan Anemia patient. Haematologica, 102(12), e506-e509.
Scopus22 WoS19 Europe PMC142017 De Sousa, S. M. C., Stowasser, M., Feng, J., Schreiber, A. W., Wang, P., Hahn, C. N., . . . Gagliardi, L. (2017). ARMC5 is not implicated in familial hyperaldosteronism type II (FH-II). Journal of Human Hypertension, 31(12), 857-859.
Scopus3 WoS1 Europe PMC32017 Losonczy, L. I., Hsieh, D., Wang, M., Hahn, C., Trivedi, T., Rodriguez, M., . . . Alter, H. (2017). The Highland Health Advocates: a preliminary evaluation of a novel programme addressing the social needs of emergency department patients. EMERGENCY MEDICINE JOURNAL, 34(9), 599-605.
WoS392016 Barnett, C., Nataren, N., Klingler-Hoffmann, M., Schwarz, Q., Chong, C., Lee, Y., . . . Scott, H. (2016). Ectrodactyly and lethal pulmonary acinar dysplasia associated with homozygous FGFR2 mutations identified by exome sequencing. Human Mutation, 37(9), 955-963.
Scopus26 WoS17 Europe PMC152016 Barnett, C. P., Nataren, N. J., Klingler-Hoffmann, M., Schwarz, Q., Chong, C. E., Lee, Y. K., . . . Scott, H. S. (2016). Cover Image, Volume 37, Issue 9. Human Mutation, 37(9), i.
2016 Ross, D. M., Altamura, H. K., Hahn, C. N., Nicola, M., Yeoman, A. L., Holloway, M. R., . . . Scott, H. S. (2016). Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene. Leukemia, 30(6), 1402-1405.
Scopus7 WoS7 Europe PMC52016 Lewinsohn, M., Brown, A. L., Weinel, L. M., Phung, C., Rafidi, G., Lee, M. K., . . . Scott, H. S. (2016). Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. Blood, 127(8), 1017-1023.
Scopus162 WoS141 Europe PMC1182016 Ling, K., Brautigan, P., Moore, S., Fraser, R., Cheah, P., Raison, J., . . . Scott, H. (2016). Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain. Genomics, 107(2-3), 88-99.
Scopus14 WoS12 Europe PMC102016 Ling, K., Brautigan, P., Moore, S., Fraser, R., Leong, M., Leong, J., . . . Scott, H. (2016). In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts. Data in Brief, 7, 282-290.
Scopus4 WoS3 Europe PMC22015 Gagliardi, L., Nataren, N., Feng, J., Schreiber, A., Hahn, C., Conwell, L., . . . Scott, H. (2015). Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss. American Journal of Medical Genetics, Part A, 167(8), 1872-1876.
Scopus10 WoS8 Europe PMC52015 Hu, Z., Scott, H., Qin, G., Zheng, G., Chu, X., Xie, L., . . . Wei, C. (2015). Revealing missing human protein isoforms based on ab initio prediction, RNA-seq and proteomics. Scientific Reports, 5(1), 10940-1-10940-15.
Scopus32 WoS26 Europe PMC172015 Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994.
Scopus161 WoS138 Europe PMC1042015 Hahn, C., Venugopal, P., Scott, H., & Hiwase, D. (2015). Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy. Immunological Reviews, 263(1), 257-278.
Scopus38 WoS33 Europe PMC322015 Hahn, C., Brautigan, P., Chong, C., Janssan, A., Venugopal, P., Lee, Y., . . . Scott, H. (2015). Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia. Leukemia, 29(8), 1795-1797.
Scopus9 WoS9 Europe PMC82015 Hahn, C., Ross, D., Feng, J., Beligaswatte, A., Hiwase, D., Parker, W., . . . Scott, H. (2015). A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia, 29(10), 2101-2104.
Scopus26 WoS23 Europe PMC222015 Hahn, C., & Hill, M. D. (2015). Early Anti-Coagulation after Ischemic Stroke due to Atrial Fibrillation is Safe and Prevents Recurrent Stroke. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 42(2), 92-95.
WoS52014 Hahn, C., & Nagdev, A. (2014). Color Doppler Ultrasound-guided Supraclavicular Brachial Plexus Block to Prevent Vascular Injection. WESTERN JOURNAL OF EMERGENCY MEDICINE, 15(6), 703-705.
WoS22014 Hahn, C., Breil, M., Schewe, J. C., Messelken, M., Rauch, S., Graesner, J. T., . . . Fischer, M. (2014). Hypertonic saline infusion during resuscitation from out-of-hospital cardiac arrest: A matched-pair study from the German Resuscitation Registry. RESUSCITATION, 85(5), 628-636.
WoS112014 Hiwase, D. K., Hahn, C. N., Babic, M., Moore, S., Butcher, C. M., Kutyna, M. M., . . . Scott, H. S. (2014). Clonal Diversity of Recurrently Mutated Genes in Myelodysplastic Syndromes. BLOOD, 124(21), 3 pages. 2014 Gagliardi, L., Schreiber, A., Hahn, C., Feng, J., Cranston, T., Boon, H., . . . Scott, H. (2014). ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 99(9), E1784-E1792.
Scopus94 WoS69 Europe PMC562014 Young, J. A., Ting, K. K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. R. (2014). Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919)). Blood, 124(19), 3034.
2013 Shah, S., & Hahn, C. (2013). A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nature Genetics, 45(10), 1226-1231.
Scopus240 WoS189 Europe PMC1632013 Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. (2013). Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919.
Scopus58 WoS54 Europe PMC432013 Recker, J., Mendling, J., & Hahn, C. (2013). How collaborative technology supports cognitive processes in collaborative process modeling: A capabilities-gains-outcome model. INFORMATION SYSTEMS, 38(8), 1031-1045.
WoS252012 Gagliardi, L., Ling, K., Kok, C., Carolan, J., Brautigan, P., Kenyon, R., . . . Scott, H. (2012). Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia. Endocrine-Related Cancer, 19(3), 19-23.
Scopus6 WoS6 Europe PMC52012 Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291.
Scopus226 WoS199 Europe PMC1602012 Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., . . . Gecz, J. (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115.
Scopus84 WoS72 Europe PMC662012 Hahn, C., & Scott, H. (2012). Spliceosome mutations in hematopoietic malignancies. Nature Genetics, 44(1), 9-10.
Scopus53 WoS43 Europe PMC402011 Hahn, C., Chong, C., Carmichael, C., Wilkins, E., Brautigan, P., Li, X., . . . Scott, H. (2011). Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nature Genetics, 43(10), 1012-1019.
Scopus482 WoS424 Europe PMC3522011 Ling, K., Brautigan, P., Hahn, C., Daish, T., Rayner, J., Cheah, P., . . . Scott, H. (2011). Deep sequencing analysis of the developing mouse brain reveals a novel microRNA. BMC Genomics, 12(1), 1-15.
Scopus50 WoS44 Europe PMC352011 Ling, K., Hewitt, C., Beissbarth, T., Hyde, L., Cheah, P., Smyth, G., . . . Scott, H. (2011). Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cerebral Cortex, 21(3), 683-697.
Scopus30 WoS27 Europe PMC242010 Carmichael, C., Wilkins, E., Bengtsson, H., Horwitz, M., Speed, T., Vincent, P., . . . Scott, H. (2010). Poor prognosis in familial acute myeloid leukaemia with combined biallelic CEBPA mutations and downstream events affecting the ATM, FLT3 and CDX2 genes. British Journal of Haematology, 150(3), 382-385.
Scopus17 WoS13 Europe PMC102010 Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., . . . Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024.
Scopus41 WoS38 Europe PMC362010 Jongmans, M., Kuiper, R., Carmichael, C., Wilkins, E., Dors, N., Carmagnac, A., . . . Hoogerbrugge, N. (2010). Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome. Leukemia, 24(1), 242-246.
Scopus78 WoS72 Europe PMC522009 Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., & Bonder, C. (2009). Sphingosine kinase-1 associates with Integrin alpha(V)beta(3) to mediate endothelial cell survival. American Journal of Pathology, 175(5), 2217-2225.
Scopus17 WoS14 Europe PMC132009 Ling, K., Hewitt, C., Beissbarth, T., Hyde, L., Ghosal, K., Cheah, P., . . . Scott, H. (2009). Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biology (Online Edition), 10(10), 1-31.
Scopus37 WoS31 Europe PMC282009 Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., . . . Gamble, J. (2009). JAM-C Induces endothelial cell permeability through its association and regulation of beta(3) integrins. Arteriosclerosis Thrombosis and Vascular Biology, 29(8), 1200-U101.
Scopus41 WoS37 Europe PMC312009 Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., & Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular & Molecular Biology Letters, 14(3), 424-441.
Scopus31 WoS23 Europe PMC152008 Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., . . . Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
Scopus75 WoS69 Europe PMC542006 Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., . . . Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067.
Scopus80 WoS80 Europe PMC532006 Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., & Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420.
Scopus76 WoS64 Europe PMC362005 Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., & Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177.
Scopus153 WoS146 Europe PMC1142005 Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., . . . Gamble, J. (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(1), 57-69.
Scopus17 WoS15 Europe PMC142004 Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., . . . Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 12212-12217.
Scopus38 WoS35 Europe PMC342004 Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., . . . Xia, P. (2004). PPARg agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: Role of diacylglycerol kinase. Circulation Research, 94(11), 1515-1522.
Scopus97 WoS88 Europe PMC762004 Hime, N., Drew, K., Hahn, C., Barter, P., & Rye, K. (2004). Apolipoprotein E enhances hepatic lipase-mediated hydrolysis of reconstituted high-density lipoprotein phospholipid and triacylglycerol in an isoform-dependent manner. Biochemistry, 43(38), 12306-12314.
Scopus20 WoS21 Europe PMC152004 Li, X., Hahn, C. N., Parsons, M., Drew, J., Vadas, M. A., & Gamble, J. R. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: Inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.
Scopus61 WoS58 Europe PMC522004 Nastasi, T., Bongiovanni, A., Campos, Y., Mann, L., Toy, J. N., Bostrom, J., . . . d'Azzo, A. (2004). Ozz-E3, a muscle-specific ubiquitin ligase, regulates β-catenin degradation during myogenesis. Developmental Cell, 6(2), 269-282.
Scopus80 WoS73 Europe PMC672003 Hime, N., Wee, K., Barter, P., & Rye, K. -A. (2003). 3P-0731 In vivo formation of high density lipoproteins containing both apolipoprotein A-I and apolipoprotein A-II in the rabbit. Atherosclerosis Supplements, 4(2), 222.
2002 De Geest, N., Bonten, E., Mann, L., De Sousa-Hitzler, J., Hahn, C., & D'Azzo, A. (2002). Genotype-phenotype correlation in inherited severe insulin resistance. Human Molecular Genetics, 11(12), 1465-1475.
Scopus149 Europe PMC862002 de Geest, N., Bonten, E., Mann, L., de Souza-Hitzler, J., Hahn, C., & d'Azzo, A. (2002). Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice. HUMAN MOLECULAR GENETICS, 11(12), 1455-1464.
WoS82 Europe PMC632000 Davey, R., Hahn, C., May, B., & Morris, H. (2000). Osteoblast gene expression in rat long bones: Effects of ovariectomy and dihydrotestosterone on mRNA levels. Calcified Tissue International, 67(1), 75-79.
Scopus35 WoS33 Europe PMC221998 Rottier, R. J., Hahn, C. N., Mann, L. W., Del Pilar Martin, M., Smeyne, R. J., Suzuki, K., & D'Azzo, A. (1998). Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: Indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. Human Molecular Genetics, 7(11), 1787-1794.
Scopus24 WoS20 Europe PMC131998 Hahn, C. N., Del Pilar Martin, M., Zhou, X. Y., Mann, L. W., & D'Azzo, A. (1998). Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin a under control of the colony-stimulating factor-1 receptor promoter. Proceedings of the National Academy of Sciences of the United States of America, 95(25), 14880-14885.
Scopus47 WoS46 Europe PMC261997 Hahn, C. N., Del Pilar Martin, M., Schröder, M., Vanier, M. T., Hara, Y., Suzuki, K., . . . D'Azzo, A. (1997). Generalized CNS disease and massive G(M1)-ganglioside accumulation in mice defective in lysosomal acid β-galactosidase. Human Molecular Genetics, 6(2), 205-211.
Scopus138 WoS123 Europe PMC1001996 Kerry, D., Dwivedi, P., Morris, H., Omdahl, J., & May, B. (1996). Transcriptional Sygernism Between Vitamin D-Rsponsive Elements in the Rat 25-Hyroxyvitamin D-3 24-Hydroxylase (CYP24) Promotor. Journal of Biological Chemistry, 271(47), 29715-29721.
Scopus115 WoS101 Europe PMC671994 Hahn, C. N., Kerry, D. M., Omdahl, J. L., & May, B. K. (1994). Identification of a vitamin D responsive element in the promoter of the rat cytochrome P450<inf>24</inf> gene. Nucleic Acids Research, 22(12), 2410-2416.
Scopus67 WoS58 Europe PMC211993 HAHN, C. N., KERRY, D. M., MAY, B. K., & OMDAHL, J. L. (1993). CHARACTERIZATION OF THE PROMOTER REGION FOR THE RAT CYTOCHROME P-45024 GENE(CYP24). JOURNAL OF BONE AND MINERAL RESEARCH, 8, S126. 1993 Dogra, S. C., Hahn, C. N., & May, B. K. (1993). Superinduction by Cycloheximide of Cytochrome P4502H1 and 5-Aminolevulinate Synthase Gene Transcription in Chick Embryo Liver. Archives of Biochemistry and Biophysics, 300(1), 531-534.
Scopus19 WoS22 Europe PMC91993 Hahn, C. N., Baker, E., Laslo, P., May, B. K., Omdahl, J. L., & Sutherland, G. R. (1993). Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20ql3.2→ql3.3. Cytogenetics and Cell Genetics, 62(4), 192-193.
Scopus25 WoS17 Europe PMC71991 Hahn, C. N., Hansen, A. J., & May, B. K. (1991). Transcriptional regulation of the chicken CYP2H1 gene: Localization of a phenobarbital-responsive enhancer domain. Journal of Biological Chemistry, 266(26), 17031-17039.
Scopus47 WoS48 Europe PMC17- Perera, T., Khayambashi, S., Jewett, G., Hahn, C., McCulloch, S., Joseph, J. T., & Chhibber, S. (n.d.). Plasmapheresis for Treatment of Light Chain Amyloidosis Related Myopathy. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 3 pages.
- Russell, A., Khayambashi, S., Fine, N. M., Chhibber, S., & Hahn, C. (n.d.). Characteristics of Carpal Tunnel Syndrome in Wild-Type Transthyretin Amyloidosis. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 5 pages.
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Conference Papers
Year Citation 2023 Scott, H. S., Zerella, J., Homan, C., Arts, P., Lin, S., Spinelli, S. J., . . . Hahn, C. N. (2023). ERG Is a New Predisposition Gene for Bone Marrow Failure and Hematological Malignancy. In BLOOD Vol. 142 (pp. 3 pages). CA, San Diego: AMER SOC HEMATOLOGY.
2022 Shah, M., Hahn, C. N., Chhetri, R., Tran, E. N. H., Singhal, D., Hogan, W. J., . . . Hiwase, D. (2022). Integrated Personalized Prediction Model Identifies a Subgroup of Wild-Type TP53therapy-Related Myeloid Neoplasm Patients with Poor Outcome. In BLOOD Vol. 140 (pp. 6964-6965). New Orleans, LA: AMER SOC HEMATOLOGY.
2022 Saygin, C., Roloff, G. W., Hahn, C. N., Chhetri, R., Gill, S., Elmariah, H., . . . Godley, L. A. (2022). Allogeneic Hematopoietic Stem Cell Transplant Outcomes in Adults with Inherited Myeloid Malignancies. In BLOOD Vol. 140 (pp. 10542-10544). LA, New Orleans: AMER SOC HEMATOLOGY.
2022 Brown, A. L., Homan, C., Drazer, M. W., Yu, K., Lawrence, D., Feng, J., . . . Godley, L. A. (2022). Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in <i>RUNX1</i>, <i>GATA2</i> and <i>DDX41</i>. In BLOOD Vol. 140 (pp. 4030-4033). LA, New Orleans: AMER SOC HEMATOLOGY.
2022 Coenen, N., Dachselt, R., Finkbeiner, B., Frenkel, H., Hahn, C., Horak, T., . . . Siber, J. (2022). Explaining Hyperproperty Violations. In S. Shoham, & Y. Vizel (Eds.), COMPUTER AIDED VERIFICATION (CAV 2022), PT I Vol. 13371 (pp. 407-429). ISRAEL, Haifa: SPRINGER INTERNATIONAL PUBLISHING AG.
2022 Hahn, C., Levy, A., Zapata, C., & Sutphin, R. (2022). DESMOPLASTIC SMALL ROUND CELL TUMOR (DSRCT) OF THE MAJOR SALIVARY GLAND: CASE REPORT. In PEDIATRIC BLOOD & CANCER Vol. 69 (pp. 1 page). WILEY. 2021 Hansen, M., & Hahn, C. (2021). Autoimmune Encephalitis: Modifiable and Non-modifiable Predictors of Relapse. In NEUROLOGY Vol. 96 (pp. 2 pages). LIPPINCOTT WILLIAMS & WILKINS. 2021 Berenbrink, P., Friedetzky, T., Hahn, C., Hintze, L., Kaaser, D., Kling, P., & Nagel, L. (2021). Infinite Balanced Allocation via Finite Capacities. In 2021 IEEE 41ST INTERNATIONAL CONFERENCE ON DISTRIBUTED COMPUTING SYSTEMS (ICDCS 2021) (pp. 965-975). ELECTR NETWORK: IEEE COMPUTER SOC.
2021 Coenen, N., Finkbeiner, B., Hahn, C., Hofmann, J., & Schillo, Y. (2021). Runtime Enforcement of Hyperproperties. In Z. Hou, & V. Ganesh (Eds.), AUTOMATED TECHNOLOGY FOR VERIFICATION AND ANALYSIS, ATVA 2021 Vol. 12971 (pp. 283-299). ELECTR NETWORK: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS12021 Hahn, C. N., Feurstein, S. K., Singhal, D., Kutyna, M. M., Chhetri, R., Wee, A., . . . Hiwase, D. (2021). Unexpected High Frequency of Pathogenic Germline Variants in Older Adults with Primary Myelodysplastic Syndrome. In BLOOD Vol. 138 (pp. 4 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
WoS12021 Schmitt, F., Hahn, C., Rabe, M. N., & Finkbeiner, B. (2021). Neural Circuit Synthesis from Specification Patterns. In M. Ranzato, A. Beygelzimer, Y. Dauphin, P. S. Liang, & J. W. Vaughan (Eds.), ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS 34 (NEURIPS 2021) Vol. 34 (pp. 13 pages). ELECTR NETWORK: NEURAL INFORMATION PROCESSING SYSTEMS (NIPS). 2020 Finkbeiner, B., Hahn, C., Hofmann, J., & Tentrup, L. (2020). Realizing ω-regular Hyperproperties. In S. K. Lahiri, & C. Wang (Eds.), COMPUTER AIDED VERIFICATION, PT II Vol. 12225 (pp. 40-63). ELECTR NETWORK: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS42019 Hahn, C. (2019). Algorithms for Monitoring Hyperproperties. In B. Finkbeiner, & L. Mariani (Eds.), RUNTIME VERIFICATION, RV 2019 Vol. 11757 (pp. 70-90). PORTUGAL, Porto: SPRINGER INTERNATIONAL PUBLISHING AG.
2019 Homan, C., Armstrong, M., Dobbins, J., Lawrence, D., Wang, P., Arts, P., . . . Brown, A. (2019). DEVELOPMENT OF A DATA PORTAL FOR AGGREGATION AND ANALYSIS OF GENOMICS DATA IN FAMILIAL PLATELET DISORDER WITH PREDISPOSITION TO MYELOID MALIGNANCY - THE RUNX1.DB. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S69). ELSEVIER SCIENCE INC. 2019 Venugopal, P., Babic, M., Barnett, C., Bray, S., Brown, A., Cheah, J., . . . Young, C. C. (2019). IMPLICATIONS OF REVERTANT SOMATIC MOSAICISM IN BONE MARROW FAILURE SYNDROMES. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S90). ELSEVIER SCIENCE INC. 2019 Cheah, J., Brown, A., Eshraghi, L., Feng, J., Schreiber, A., Babic, M., . . . Scott, H. (2019). AN INTEGRATIVE GENOMIC APPROACH TO EXAMINE MUTATIONS AND BIOLOGICAL PATHWAYS ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCY DEVELOPMENT IN DDX41 MUTATED FAMILIES. In EXPERIMENTAL HEMATOLOGY Vol. 76 (pp. S61). ELSEVIER SCIENCE INC. 2019 Singhal, D., Hahn, C. N., Moma, L. D., Wee, L. Y. A., Chhetri, R., Babic, M., . . . Hiwase, D. K. (2019). Deleterious Germline Variants, Especially in the DNA Repair Pathway, Are Common in Patients with Non-Related Multiple Cancers, One of Them Being Hematological Malignancy. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
WoS12019 Venugopal, P., Cheah, J. J. C., Eshraghi, L., Shahrin, N. H., Homan, C., Feng, J., . . . Scott, H. S. (2019). An Integrative Genomic Approach to Examine Mutations and Biological Pathways Associated with Hematological Malignancy Development in DDX41 Mutated Families. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
WoS22019 Brown, A. L., Babic, M., Schreiber, A., Feng, J., Dobbins, J., Arts, P., . . . Scott, H. S. (2019). Familial Clustering of Hematological Malignancies: Harbingers of Wider Germline Cancer Susceptibility. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
WoS12019 Hahn, C. N., Babic, M., Brautigan, P. J., Venugopal, P., Phillips, K., Dobbins, J., . . . Scott, H. S. (2019). Australian Familial Haematological Cancer Study - Findings from 15 Years of Aggregated Clinical, Genomic and Transcriptomic Data. In BLOOD Vol. 134 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY.
WoS22019 Coenen, N., Finkbeiner, B., Hahn, C., & Hofmann, J. (2019). The Hierarchy of Hyperlogics. In 2019 34TH ANNUAL ACM/IEEE SYMPOSIUM ON LOGIC IN COMPUTER SCIENCE (LICS) (pp. 13 pages). CANADA, Vancouver: IEEE.
WoS172019 Hahn, C., Stenger, M., & Tentrup, L. (2019). Constraint-Based Monitoring of Hyperproperties. In T. Vojnar, & L. Zhang (Eds.), TOOLS AND ALGORITHMS FOR THE CONSTRUCTION AND ANALYSIS OF SYSTEMS, PT II Vol. 11428 (pp. 115-131). CZECH REPUBLIC, Prague: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS162018 Finkbeiner, B., Hahn, C., Stenger, M., & Tentrup, L. (2018). RVHyper: A Runtime Verification Tool for Temporal Hyperproperties. In D. Beyer, & M. Huisman (Eds.), TOOLS AND ALGORITHMS FOR THE CONSTRUCTION AND ANALYSIS OF SYSTEMS, TACAS 2018, PT II Vol. 10806 (pp. 194-200). GREECE, Thessaloniki: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS222018 Hahn, C., Huntgeburth, J., & Zarnekow, R. (2018). Leverage Once, Earn Repeatedly-Capabilities for Creating and Appropriating Value in Cloud Platform Ecosystems. In R. Lamboglia, A. Cardoni, R. P. Dameri, & D. Mancini (Eds.), NETWORK, SMART AND OPEN: THREE KEYWORDS FOR INFORMATION SYSTEMS INNOVATION Vol. 24 (pp. 143-164). ITALY, Verona: SPRINGER INTERNATIONAL PUBLISHING AG.
2018 Finkbeiner, B., Hahn, C., & Hans, T. (2018). MGHyper: Checking Satisfiability of HyperLTL Formulas Beyond the ∃*∀* Fragment. In S. K. Lahiri, & C. Wang (Eds.), AUTOMATED TECHNOLOGY FOR VERIFICATION AND ANALYSIS (ATVA 2018) Vol. 11138 (pp. 521-527). CA, Los Angeles: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS72018 Finkbeiner, B., Hahn, C., Lukert, P., Stenger, M., & Tentrup, L. (2018). Synthesizing Reactive Systems from Hyperproperties. In H. Chockler, & G. Weissenbacher (Eds.), COMPUTER AIDED VERIFICATION (CAV 2018), PT I Vol. 10981 (pp. 289-306). ENGLAND, Oxford: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS192018 Finkbeiner, B., Hahn, C., & Torfah, H. (2018). Model Checking Quantitative Hyperproperties. In H. Chockler, & G. Weissenbacher (Eds.), COMPUTER AIDED VERIFICATION (CAV 2018), PT I Vol. 10981 (pp. 144-163). ENGLAND, Oxford: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS222017 Finkbeiner, B., Hahn, C., & Stenger, M. (2017). EAHyper: Satisfiability, Implication, and Equivalence Checking of Hyperproperties. In R. Majumdar, & V. Kuncak (Eds.), COMPUTER AIDED VERIFICATION (CAV 2017), PT II Vol. 10427 (pp. 564-570). GERMANY, Heidelberg: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS222017 Finkbeiner, B., Hahn, C., Stenger, M., & Tentrup, L. (2017). Monitoring Hyperproperties. In S. Lahiri, & G. Reger (Eds.), RUNTIME VERIFICATION (RV 2017) Vol. 10548 (pp. 190-207). WA, Seattle: SPRINGER INTERNATIONAL PUBLISHING AG.
WoS182017 Singhal, D., Wee, A., Parker, W., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2017). Presence of Rare Germline Variants in Fanconi Anaemia Pathway Genes Confers a Poor Prognosis Comparable to <i>TP53</i> Mutations in Therapy-Related Myeloid Neoplasms. In BLOOD Vol. 130 (pp. 3 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
WoS22017 Branford, S., Wang, P., Yeung, D., Purins, A., Marum, J. E., Nataren, N., . . . Hughes, T. P. (2017). Integrative Genomics Reveals Cancer Associated Mutations Are Common at Diagnosis of CML in Patients with Poor Response to TKI Therapy. In BLOOD Vol. 130 (pp. 4 pages). Atlanta, GA: AMER SOC HEMATOLOGY. 2017 Hahn, C. N., Wee, A., Babic, M., Feng, J., Wang, P., Kutyna, M. M., . . . Scott, H. S. (2017). Duplication on Chromosome 14q Identified in Familial Predisposition to Myeloid Malignancies and Myeloproliferative Neoplasms. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
WoS22017 Brown, A. L., Churpek, J., Hahn, C. N., & Scott, H. S. (2017). Clonal Evolution in the Setting of Germline Predisposition. In BLOOD Vol. 130 (pp. 1 page). GA, Atlanta: AMER SOC HEMATOLOGY.
WoS32016 Singhal, D., Wee, L. A., Parker, W. T., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2016). The Frequency of Genetic Mutations in T-MN Is High and Comparable to Primary MDS but the Spectrum Is Different. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2016 Bassal, M. A., Leo, P., Samaraweera, S. E., Maung, K. Z. Y., Babic, M., Venugopal, P., . . . D'Andrea, R. (2016). Metabolic Profiling of Adult Acute Myeloid Leukemia (AML). In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY.
WoS12016 Brown, A. L., Hahn, C. N., Carmichael, C., Wilkins, E., Babic, M., Chong, C. -E., . . . Scott, H. S. (2016). Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline <i>RUNX1</i> Mutations. In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2015 Hahn, C. N., Babic, M., Schreiber, A. W., Kutyna, M. M., Wee, L. A., Brown, A. L., . . . Hiwase, D. (2015). Rare and Common Germline Variants Contribute to Occurrence of Myelodysplastic Syndrome. In BLOOD Vol. 126 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY.
WoS32015 Branford, S., Wang, P. P. S., Parker, W. T., Yeung, D., Marum, J. E., Stangl, D., . . . Hughes, T. P. (2015). High Incidence of Mutated Cancer-Associated Genes at Diagnosis in CML Patients with Early Transformation to Blast Crisis. In BLOOD Vol. 126 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY. 2015 Labes, S., Hahn, C., & Zarnekow, R. (2015). The Value of Community Clouds for Collaboration in the Public Sector. In AMCIS 2015 PROCEEDINGS (pp. 13 pages). PR, Fajardo: ASSOC INFORMATION SYSTEMS. 2015 Hahn, C., Zarnekow, R., & Roeher, D. (2015). A value proposition oriented typology of electronic marketplaces for B2B SaaS applications. In AMCIS 2015 PROCEEDINGS (pp. 15 pages). PR, Fajardo: ASSOC INFORMATION SYSTEMS. 2014 Reichert, M., Bakir, B., Hahn, C., Rhim, A. D., Vonderheide, R. H., Reynolds, A. B., . . . Rustgi, A. K. (2014). P120catenin Facilitates Pancreatic Regeneration and Monoallelic Loss Accelerates Kras-Driven Carcinogenesis and Metastasis. In GASTROENTEROLOGY Vol. 146 (pp. S173). IL, Chicago: W B SAUNDERS CO-ELSEVIER INC. 2014 Heeg, S., Das, K. K., Reichert, M., Takano, S., Bakir, B., Lieberman, A. E., . . . Rustgi, A. K. (2014). The ETS Transcription Factor ETV5 Regulates Ductal Morphogenesis and Differentiation in Association With SOX9. In GASTROENTEROLOGY Vol. 146 (pp. S138). IL, Chicago: W B SAUNDERS CO-ELSEVIER INC. 2014 Heeg, S., Das, K. K., Reichert, M., Takano, S., Bakir, B., Hahn, C., . . . Rustgi, A. K. (2014). The ETS-Transcription Factor Etv1 Is an Important Regulator of Pancreatic Carcinogenesis and Invasion. In GASTROENTEROLOGY Vol. 146 (pp. S15). IL, Chicago: W B SAUNDERS CO-ELSEVIER INC. 2014 Ling, K., Lee, H., Brautigan, P., Moore, S., Fraser, R., Cheah, P., . . . Scott, H. (2014). Deciphering the secret role of Sox4 gene locus during mouse cerebral corticogenesis. In Journal of Neurochemistry Vol. 130 (pp. 8). Kaohsiung, Taiwan: Wiley. 2014 Casolari, D. A., Iarossi, D. G., Butcher, C. M., Bray, S. C., Parker, W. T., Hahn, C. N., . . . D'Andrea, R. J. (2014). Aberrant Activation of Epidermal Growth Factor Receptor in MPN May Respond to the Kinase Inhibitor Gefitinib. In BLOOD Vol. 124 (pp. 3 pages). San Francisco, CA: AMER SOC HEMATOLOGY. 2013 Reichert, M., Takano, S., von Burstin, J., Heeg, S., Kim, S. -B., Lee, J. -S., . . . Rustgi, A. K. (2013). The Prrx1 Homeodomain Transcription Factor Plays a Central Role in Pancreatic Regeneration and Carcinogenesis. In GASTROENTEROLOGY Vol. 144 (pp. S143). FL, Orlando: W B SAUNDERS CO-ELSEVIER INC. 2013 Heeg, S., Reichert, M., Takano, S., Wu, K. K., Botta, G. P., Bakir, B., . . . Rustgi, A. K. (2013). The Ets-Transcription Factor Etv1 Induces Invasion and Enhances Self Renewal Capacity in PanIN and Pdac. In GASTROENTEROLOGY Vol. 144 (pp. S12-S13). FL, Orlando: W B SAUNDERS CO-ELSEVIER INC. 2013 Reichert, M., Bakir, B., Hahn, C., Rhim, A. D., Vonderheide, R. H., Adsay, V., & Rustgi, A. K. (2013). Inactivation of a Single Allele of P120catenin Dramatically Accelerates KRAS-Driven Carcinogenesis in the Pancreas. In GASTROENTEROLOGY Vol. 144 (pp. S81). FL, Orlando: W B SAUNDERS CO-ELSEVIER INC. 2013 Hahn, C., Repschlager, J., Erek, K., & Zarnekow, R. (2013). An Exploratory Study on Cloud Strategies. In AMCIS 2013 PROCEEDINGS (pp. 9 pages). IL, Chicago: ASSOC INFORMATION SYSTEMS. 2011 Hahn, C., Recker, J., & Mendling, J. (2011). An Exploratory Study of IT-Enabled Collaborative Process Modeling. In M. ZurMuehlen, & J. W. Su (Eds.), BUSINESS PROCESS MANAGEMENT WORKSHOPS Vol. 66 (pp. 61-+). NJ, Stevens Inst Technol, Hoboken: SPRINGER-VERLAG BERLIN.
WoS112011 Rao, N., Butcher, C., Neufing, P., Bray, S., Hahn, C., Scott, H., . . . D'Andrea, R. (2011). Mechanisms of Co-operation of DNMT3A Mutations with JAK2 V617F Through Histone H4 Arginine 3 Provides New Insights in MPN Disease Pathogenesis. In 53rd ASH Annual Meeting and Exposition Vol. 118 (pp. 1). Washington DC: AMER SOC HEMATOLOGY. 2003 Hime, N., Wee, K., Barter, P., & Rye, K. A. (2003). <i>In vivo</i> formation of high density lipoproteins containing both apolipoprotein A-I and apolipoprotein A-II in the rabbit. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 4 (pp. 222). KYOTO, JAPAN: ELSEVIER IRELAND LTD. 2003 Hime, N., Drew, K., Hahn, C., & Rye, K. A. (2003). Influence of apolipoprotein E isoforms on hepatic lipase-mediated phospholipid and triacylglycerol hydrolysis in reconstituted high density lipoproteins. In ATHEROSCLEROSIS SUPPLEMENTS Vol. 4 (pp. 222). KYOTO, JAPAN: ELSEVIER IRELAND LTD. 1999 De Geest, N., Mann, L., De Sousa-Hitzler, J., Hahn, C., Rottier, R., & D'Azzo, A. (1999). Lysosomal neuraminidase deficiency in mice: a model for sialidosis.. In AMERICAN JOURNAL OF HUMAN GENETICS Vol. 65 (pp. A26). UNIV CHICAGO PRESS.
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Conference Items
Year Citation 2018 Singhal, D., Wee, A., Kutyna, M. M., Babic, M., Chhetri, R., Parker, W., . . . Hiwase, D. K. (2018). Therapy-Related Myeloid Neoplasms (T-MN) and Primary MDS (PMDS) Patients with Very Low (VL) or Low (L) IPSS-R Score Share Clinical and Biological Characteristics and Have Similar Outcome. Poster session presented at the meeting of BLOOD. San Diego, CA: AMER SOC HEMATOLOGY.
2017 Oftedal, B. E., Lundgren, B. A., Bratland, E., Wolff, A. B., Hamm, D., Gan, P. -Y., . . . Scott, H. S. (2017). T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ. Poster session presented at the meeting of SCANDINAVIAN JOURNAL OF IMMUNOLOGY. Stockholm, SWEDEN: WILEY. 2017 Singhal, D., Wee, L. A., Babic, M., Parker, W., Moore, S., Feng, J., . . . Hiwase, D. (2017). THERAPY RELATED MYELOID NEOPLASMS (T-MN) SHOW HIGH MUTATION FREQUENCY AND A SPECTRUM DIFFERENT FROM PRIMARY MDS. Poster session presented at the meeting of LEUKEMIA RESEARCH. Valencia, SPAIN: PERGAMON-ELSEVIER SCIENCE LTD.
2017 De Sousa, S. M. C., Stowasser, M., Feng, J., Schreiber, A. W., Hahn, C. N., Torpy, D. J., . . . Scott, H. S. (2017). Sequence variants in <i>ARMC5</i> are not implicated in familial hyperaldosteronism type II. Poster session presented at the meeting of CLINICAL ENDOCRINOLOGY. WILEY-BLACKWELL. 2016 Beck, D., Thoms, J., Palu, C., Herold, T., Shah, A., Olivier, J., . . . Pimanda, J. (2016). INTEGRATIVE ANALYSIS OF LINCRNA EXPRESSION IN 922 ACUTE MYELOID LEUKEMIA PATIENTS REVEALS MULTIPLE PROGNOSTIC GENE SIGNATURES. Poster session presented at the meeting of HAEMATOLOGICA. Copenhagen, DENMARK: FERRATA STORTI FOUNDATION.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Role of Inherited and Acquired Genetic Changes in the Molecular Pathogenesis of Therapy-Related Myeloid Neoplasms Doctor of Philosophy Doctorate Full Time Dr Deepak Singhal 2023 Co-Supervisor Multiplex assay of variant effect (MAVE) to measure functional effects following saturation mutagenesis of GATA2 and RUNX1. Doctor of Philosophy Doctorate Full Time Mr Wen Teng 2022 Co-Supervisor Investigation of germline ERG mutations associated with predisposition to haematological malignancies. Doctor of Philosophy Doctorate Full Time Ms Jiarna Rose Zerella -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2012 - 2016 Co-Supervisor Identification and Characterisation of Genetic Lesions that Predispose to and Gene Expression Patterns that Contribute to Myeloid Malignancies Doctor of Philosophy Doctorate Full Time Ms Parvathy Venugopal 2009 - 2013 Co-Supervisor Genetics and Functional Characterization of GATA2, a Novel Cancer Gene in Familial Leukaemia Doctor of Philosophy Doctorate Full Time Mr Chan Eng Chong 2000 - 2005 Co-Supervisor Characterisation of a novel gene p73RhoGAP in angiogenesis Doctor of Philosophy Doctorate Full Time Mrs Zhi Su
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