Dr Christina Bursill

Christina Bursill
Adelaide Medical School
Faculty of Health and Medical Sciences

Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Department of Health and Medical Science. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.

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Dr Christina Bursill

Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Department of Health and Medical Science. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.

 

Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Department of Health and Medical Science. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.

 

 

Appointments

Date Position Institution name
2017 Senior Research Fellow The University of Adelaide

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review

Education

Date Institution name Country Title
The University of Adelaide Australia BSc
University of Adelaide, Adelaide Australia PhD
The University of Adelaide Australia Hons 1

Postgraduate Training

Date Title Institution Country
2017 Leader Plaque Biology and New Blood Vessel Area South Australian Health and Medical Research Institute, Adelaide Australia
2010 - 2016 Leader Immunobiology Group The Heart Research Institute, Newtown Australia
2007 - 2010 Senior Research Officer The Heart Research Institute, Newtown Australia
2001 - 2006 Postdoctoral Fellow University of Oxford, Oxford United Kingdom

Research Interests

Cardiovascular Medicine and Haematology

Journals

Year Citation
2017 Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L. ... Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. FASEB Journal, 31, 3, 1179-1192.
10.1096/fj.201600540R
2017 Chen, X., Duong, M. -. N., Psaltis, P. J., Bursill, C. A. & Nicholls, S. J. (2017). High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes.. Cardiovascular diabetology, 16, 1, 121-.
10.1186/s12933-017-0605-8
2017 Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M. ... Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. D. Jourd'heuil (Ed.). PLoS ONE, 12, 3, e0174773-1-e0174773-15.
10.1371/journal.pone.0174773
2017 Ravindran, D., Ridiandries, A., Vanags, L., Henriquez, R., Cartland, S., Tan, J. & Bursill, C. (2017). Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. A. Boissonnas (Ed.). PLoS ONE, 12, 3, -.
10.1371/journal.pone.0173224
2017 Tan, J. T., Prosser, H. C., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T. ... Bursill, C. A. (2017). High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I (vol 65, pg 3091, 2016). DIABETES, 66, 4, -.
10.2337/db17-er04b
2017 Vanags, L., Tan, J., Santos, M., Michael, P., Ali, Z., Bilek, M. ... Bursill, C. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 7, 2141-2150.
10.1016/j.nano.2017.06.012
2017 van der Vorst, E., Theodorou, K., Wu, Y., Hoeksema, M., Goossens, P., Bursill, C. ... Biessen, E. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. Cell Metabolism, 25, 1, 197-207.
10.1016/j.cmet.2016.10.013
2016 Lam, Y., Lecce, L., Tan, J., Bursill, C., Handelsman, D. & Ng, M. (2016). Androgen receptor-mediated genomic androgen action augments ischemia-induced neovascularization. Endocrinology, 157, 12, 4853-4864.
10.1210/en.2016-1301
2016 Ridiandries, A., Tan, J. & Bursill, C. (2016). The role of CC-chemokines in the regulation of angiogenesis. International Journal of Molecular Sciences, 17, 11, 1856-1-1856-16.
10.3390/ijms17111856
2016 Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L., Lam, Y., Tan, J. ... Bursill, C. (2016). Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15, 1, 150-1-150-12.
10.1186/s12944-016-0322-4
2016 Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T. ... Bursill, C. (2016). High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor Class B Type I. Diabetes, 65, 10, 3091-3103.
10.2337/db15-1668
2015 Chalmers, A., Cohen, A., Bursill, C. & Myerscough, M. (2015). Bifurcation and dynamics in a mathematical model of early atherosclerosis: how acute inflammation drives lesion development. Journal of Mathematical Biology, 71, 6, 1451-1480.
10.1007/s00285-015-0864-5
2015 Kim, C., Mitchell, J., Bursill, C., Sowers, A., Thetford, A., Cook, J. ... Davies, M. (2015). The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE¯⁄¯mice. Atherosclerosis, 240, 1, 234-241.
10.1016/j.atherosclerosis.2015.03.012
2015 Tan, J., Ng, M. & Bursill, C. (2015). The role of high-density lipoproteins in the regulation of angiogenesis. Cardiovascular Research, 106, 2, 184-193.
10.1093/cvr/cvv104
2014 Prosser, H., Tan, J., Dunn, L., Patel, S., Vanags, L., Bao, S. ... Bursill, C. (2014). Multifunctional regulation of angiogenesis by high-density lipoproteins. Cardiovascular Research, 101, 1, 145-154.
10.1093/cvr/cvt234
2014 Brown, B., Kim, C., Torpy, F., Bursill, C., McRobb, L., Heather, A. ... Van Reyk, D. (2014). Supplementation with carnosine decreases plasma triglycerides andmodulates atherosclerotic plaque composition in diabetic apoE-/- mice. Atherosclerosis, 232, 2, 403-409.
10.1016/j.atherosclerosis.2013.11.068
2014 Tan, J., Hamish, H., Vanags, L., Monger, S., Ng, M. & Bursill, C. (2014). High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α. FASEB Journal, 28, 1, 206-217.
10.1096/fj.13-233874
2014 Dunn, L., Simpson, P., Prosser, H., Lecce, L., Yuen, G., Buckle, A. ... Ng, M. (2014). A critical role for Thioredoxin- Interacting protein in diabetes-related impairment of angiogenesis. Diabetes, 63, 2, 675-687.
10.2337/db13-0417
2013 Van Der Vorst, E., Vanags, L., Dunn, L., Prosser, H., Rye, K. & Bursill, C. (2013). High-density lipoproteins suppress chemokine expression and proliferation in human vascular smooth muscle cells. FASEB Journal, 27, 4, 1413-1425.
10.1096/fj.12-212753
2013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M. & Bursill, C. (2013). Murine model of wound healing. Journal of Visualized Experiments, 2013, 75, e50265-1-e50265-6.
10.3791/50265
2013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M. & Bursill, C. (2013). Murine model of wound healing.. Journal of visualized experiments : JoVE, 75, -.
2012 Prosser, H., Ng, M. & Bursill, C. (2012). The role of cholesterol efflux in mechanisms of endothelial protection by HDL. Current Opinion in Lipidology, 23, 3, 182-189.
10.1097/MOL.0b013e328352c4dd
2011 Di Bartolo, B., Vanags, L., Tan, J., Bao, S., Rye, K., Barter, P. & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit.. Lipids in health and disease, 10, 1, 224-224.
10.1186/1476-511X-10-224
2010 Bursill, C., Castro, M., Beattie, D., Nakhla, S., Van Der Vorst, E., Heather, A. ... Rye, K. (2010). High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 9, 1773-1778.
10.1161/ATVBAHA.110.211342
2009 Rye, K., Bursill, C., Lambert, G., Tabet, F. & Barter, P. (2009). The metabolism and anti-atherogenic properties of HDL. Journal of Lipid Research, 50, SUPPL., S195-S200.
10.1194/jlr.R800034-JLR200
2009 Stevenson, N., Addley, M., Ryan, E., Boyd, C., Carroll, H., Paunovic, V. ... Johnston, J. (2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. Journal of Leukocyte Biology, 85, 2, 289-297.
10.1189/jlb.0708394
2009 Seki, E., De Minicis, S., Gwak, G., Kluwe, J., Inokuchi, S., Bursill, C. ... Schwabe, R. (2009). CCR1 and CCR5 promote hepatic fibrosis in mice. Journal of Clinical Investigation, 119, 7, 1858-1870.
10.1172/JCI37444
2009 Bursill, C., McNeill, E., Wang, L., Hibbitt, O., Wade-Martins, R., Paterson, D. ... Channon, K. (2009). Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition. Gene Therapy, 16, 1, 93-102.
10.1038/gt.2008.141
2008 McAteer, M., Schneider, J., Ali, Z., Warrick, N., Bursill, C., Von Zur Muhlen, C. ... Choudhury, R. (2008). Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1, 77-83.
10.1161/ATVBAHA.107.145466

Conference Papers

Year Citation
2008 Ali, Z., Bursill, C., Douglas, G., McNeill, E., Papaspyridonos, M., Tatham, A. ... Channon, K. (2008). CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.. 80th Annual Scientific Session of the American-Heart-Association. Orlando, FL.
10.1161/CIRCULATIONAHA.107.753558

Conference Items

Year Citation
2016 Tan, J., Hourigan, S., Zhang, J., Wong, N., Tepper, E., Prosser, H. ... Bursill, C. (2016). miRNA-181c and its putative target TRIM2 mediate the ability of high density lipoproteins to rescue diabetes-impaired angiogenesis. 76th Scientific Sessions of the American Diabetes Association. New Orleans, LA.
2015 Tan, J. T., Prosser, H. C., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T. ... Bursill, C. A. (2015). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor-BI and Restoration of VEGF and HIF-1 alpha Stability. 75th Scientific Sessions of the American-Diabetes-Association. Boston, MA.
2014 Van der Vorst, E., Theodorou, K., Plat, J., Van Eck, M., Rye, K., Bursill, C. ... Donners, M. (2014). High density lipoproteins exert pro-inflammatory effects on macrophages via IKK2-and NIK-independent NF-kB activation. 3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology. Barcelona, SPAIN.
10.1093/cvr/cvu075.2
2013 Morton, J., Bao, S., Celermajer, D. S., Ng, M. K. & Bursill, C. A. (2013). Strikingly Different Atheroprotective Effects of Apolipoprotein A-I in Early-Stage Versus Late-Stage Atherosclerosis. Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX.
2013 Prosser, H. C., Tan, J. T., Dunn, L. L., Patel, S., Vanags, L. Z., Monger, S. ... Bursill, C. A. (2013). Multifunctional Regulation of Angiogenesis by High Density Lipoproteins. Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX.
2012 Quigley, A. F., Summers, F., Barrett, T., Bursill, C. & Hawkins, C. (2012). A novel role of myeloperoxidase in the induction of endoplasmic reticulum (ER) stress.
10.1016/j.freeradbiomed.2012.08.561
2012 Quigley, A. F., Summers, F. A., Barrett, T. J., Bursill, C. A. & Hawkins, C. L. (2012). A Novel Role for Myeloperoxidase in the Induction of C/EBP-Homologous Protein (CHOP). 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM). San Diego, CA.
10.1016/j.freeradbiomed.2012.10.438

·National Heart Foundation Lin Huddleston Foundation Fellowship (2017-2022)

            Chief Investigator: Christina Bursill (CIA)

            Amount: ~$750,000 over 5 years

 

·Diabetes Australia Research (DART) grant (2017)

Title: ‘Micromanaging’ high-density lipoprotein-induced rescue of diabetes-impaired angiogenesis

Chief Investigators: Joanne Tan and Christina Bursill

            Amount: $60,000

 

· NAB Career Re-start Grant (2016)

Title: Reversing the progression of atherosclerosis

Chief Investigators: Christina Bursill (CIA),

            Amount: $60,000 over one year

 

· ARC Discovery Grant (2016)

Title: Dynamics of atherosclerotic plaque formation, growth and regression

Chief Investigators: Mary Myerscough (CIA), Charlie Macaskill (CIB), Christina Bursill (PI).

            Amount: $218,768 over three years

 

· University of Sydney - Thompson Fellowship (2016)

            Title: Using the "Good Cholesterol" to increase stent longevity

            Chief Investigator: Christina Bursill (CIA)

            Amount: $90, 000 over one year

 

· University of Sydney Bridging Grant (2015)

            Title: Different athero-protective properties of HDL in early versus late atherosclerosis

            Chief Investigators: Christina Bursill (CIA)

            Amount: $30, 000 over 1 year

 

· NHMRC Project Grant (2015)

Title: Oxidative Regulation of the Na pump – a new player in vascular function in health and disease.

Chief Investigators: Gemma Figtree (CIA), Christina Bursill (CIB), A/Prof Ravinay Bhindi (CIC), Prof Keith Channon (CID), A/Prof Clare Hawkins (CIE), Dr Ben Davies (CIF), Prof Richard Cohen (CIG).

            Amount: $488,816 over three years

 

· University of Sydney Bridging Grant (2013)

            Title: Differential Regulation of Angiogenesis by CC-Chemokines

            Chief Investigators: Christina Bursill (CIA)

            Amount: $30, 000 over 1 year

 

· NHMRC project grant (2010-2013)

            Title: Multifunctional regulation of Angiogenesis by High Density Lipoproteins

            Chief Investigators:  Martin Ng (CIA), Christina Bursill (CIB)

            Amount: $476, 000 over 3 years

 

· Heart Foundation Career Development Fellowship (2008-2013)

Title: The Role of Chemokines in the Anti-Atherosclerotic Effects of HDL

Chief Investigator: Christina Bursill

Amount: $515,000 – includes 5 years salary, travel funds and equipment support.

 

·Bushell Foundation (2008-2011)

Title: Understanding the Anti-Atherosclerotic Properties of High Density Lipoproteins

            Investigator: Christina Bursill

Amount: $250, 000 over 3 years

 

· British Heart Foundation Program Grant (2005-2007):

Title: Evaluation of Broad Spectrum Chemokine agonists to Inhibit Atherosclerosis

Investigators: Keith Channon, David Greaves, and Christina Bursill

Amount: £715,961 over 5 years

 

· British Heart Foundation Project Grant (2001-2004):

Title: Evaluation of Broad Spectrum CC-Chemokine antagonists to Inhibit Inflammatory Cell Recruitment in Atherogenesis.

Investigators: David Greaves, Keith Channon, and Christina Bursill

Amount: £152,326 over 3 years. Based on the success of the project, the initial grant was extended for a further 2.5 years (£126,939) based on my research.

 

Undergraduate Teaching:

·1997-98: Tutor for 1st year Medical students in Problem Based Learning, Department of Medicine, University of Adelaide.

·1998-2000: Demonstrator for 2nd year Science students in Cardiovascular Physiology, Department of Physiology, University of Adelaide.

·2001: Lecturer to 2nd year Medical students on Lipoprotein Metabolism, Department of Pathology, University of Oxford, UK.

·2001, 2002: Demonstrator for 2nd year Medical Students in Atherosclerosis and Thrombosis, Department of Pathology, University of Oxford, UK.

·2004-2006: Lecturer to 3rd year Medical students in ‘Methods and Approach in Scientific Research’. Department of Medicine, University of Oxford, UK.

·2015-2026: Lecturer to 3rd year Physiology students on “Vascular Inflammation”, University of Sydney, NSW.

Completed PhD Students as Primary Supervisor:

1. Name: Ziad Ali, MB ChB (Hons) DPhil MRCS MRCP

Candidature: August 2003-October 2006

Current position: NIH Career Development Fellow, Columbia University, NY, USA.

 

2. Name: Belinda DiBartolo, (Hons 1) BMedSc

Candidature: May 2006-May 2009

Current Position: Senior Postdoctoral Fellow, NHMRC Early-Career Fellow, SAHMRI.

 

3. Name: Dr Jamie Morton

Candidature: Feb 2010-Apr 2013

Current Position: Clinical Cardiologist, Royal Adelaide Hospital

Awards: Offered both the NHMRC and the Heart Foundation PhD scholarships. Received a Young Investigator Award from the Cardiac Society of Australia and New Zealand, Brisbane, 2012.

 

4. Name: Laura Vanags BSc (Hons1) PhD

Candidature: July 2012 – May 2016

Current Position: Maternity leave

Awards: NHF PhD Scholarship, AAS winner of 2 x Young Investigator Award (Oral, 2013 & 2015). Received NHF Exchange and Collaboration Award ($5000).

 

5. Name: Anisyah Ridiandries BSc (Hons 1) PhD

Candidature: March 2012 – Dec 2015

Current Position: Postdoctoral researcher, Kolling Institute, Sydney (Jan 2017)

Awards: James King of Irrawang Travelling Scholarship (USyd) to attend ATVB 2015, San Francisco, CA, USA ($1500) and visit laboratories around the USA.

Editorial Boards

Date Role Editorial Board Name Country
2014 - ongoing Associate Editor Journal of Biochemistry
2013 - ongoing Associate Editor PLoS ONE
Phone
0881284788
Campus
North Terrace
Org Unit
Faculty of Health and Medical Sciences

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