Associate Professor Christina Bursill
Grant-Funded Researcher (D)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Faculty of Health and Medical Sciences. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
Our group is interested in investigating new mechanisms and targets that underlie the development of fatty deposits in the arteries of the heart, a process called atherosclerosis, that causes heart attacks. We also undertake research looking at the regulation of new blood vessel formation (angiogenesis), which can determine how well a heart attack patient recovers. We have a host on pathophysiologically relevant in vitro and in vivo models established in our laboratory.
Project 1
Title: The effect of fenofibrate on wound healing
Description: Human trials have found that the risk of amputation following a foot ulcer is reduced with fenofibrate (Vitamin B) supplementation. In vitro and in vivo studies have also shown that angiogenesis is increased with the addition of fenofibrate. This study will determine if topically applied fenofibrate increases would healing in an in vivo model established in our laboratory.
Project available for: Honours
Location: SAHMRI
Research project start: Semester 1
Project 2
Title: The role of the glycoprotein receptor ASGR1 in unstable atherosclerosis
Description: A GWAS study has identified that a mutation in ASGR1 reduces the risk of a cardiovascular event by 34%. The mechanisms for this are poorly understood and will be investigated using in vitro and in vivo models in this project.
Project available for: Honours
Location: SAHMRI
Research project start: Semester 1
-
Appointments
Date Position Institution name 2017 - ongoing Heart Foundation Lin Huddleston Senior Research Fellow University of Adelaide 2017 - ongoing Senior Research Fellow The University of Adelaide -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title The University of Adelaide Australia BSc The University of Adelaide Australia Hons 1 University of Adelaide, Adelaide Australia PhD -
Postgraduate Training
Date Title Institution Country 2017 Leader Plaque Biology and New Blood Vessel Area South Australian Health and Medical Research Institute, Adelaide Australia 2010 - 2016 Leader Immunobiology Group The Heart Research Institute, Newtown Australia 2007 - 2010 Senior Research Officer The Heart Research Institute, Newtown Australia 2001 - 2006 Postdoctoral Fellow University of Oxford, Oxford United Kingdom -
Research Interests
-
Journals
Year Citation 2024 Chen, R., Sandeman, L., Nankivell, V., Tan, J. T. M., Rashidi, M., Psaltis, P. J., . . . Li, J. (2024). Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system. Scientific Reports, 14(1), 12359-1-12359-10.
2024 Psaltis, J. P., Marathe, J. A., Nguyen, M. T., Le, R., Bursill, C. A., Marathe, C. S., . . . Psaltis, P. J. (2024). Incretin-based therapies for the management of cardiometabolic disease in the clinic: Past, present, and future. Medicinal Research Reviews, 37 pages.
2024 Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. J. (2024). Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nature Communications, 15(1), 21 pages.
2024 Psaltis, P. J., Nguyen, M. T., Singh, K., Sinhal, A., Wong, D. T. L., Alcock, R., . . . Nicholls, S. J. (2024). Optical coherence tomography assessment of the impact of colchicine on non-culprit coronary plaque composition after myocardial infarction. CARDIOVASCULAR RESEARCH, 11 pages.
2024 Moore, E., Robson, A. J., Crisp, A. R., Cockshell, M. P., Burzava, A. L. S., Ganesan, R., . . . Bonder, C. S. (2024). Study of the Structure of Hyperbranched Polyglycerol Coatings and their Anti-Biofouling and Anti-Thrombotic Applications. Advanced Healthcare Materials, 13(26), 2401545.
Scopus12024 Tan, J. T. M., Cheney, C. V., Bamhare, N. E. S., Hossin, T., Bilu, C., Sandeman, L., . . . Bursill, C. A. (2024). Female Psammomys obesus Are Protected from Circadian Disruption-Induced Glucose Intolerance, Cardiac Fibrosis and Adipocyte Dysfunction. International Journal of Molecular Sciences, 25(13), 7265-1-7265-19.
2024 Tan, J. T. M., Price, K. J., Fanshaw, S. -R., Bilu, C., Pham, Q. T., Pham, A., . . . Bursill, C. A. (2024). Exercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet. International Journal of Molecular Sciences, 25(14), 7756-1-7756-13.
Scopus12024 Hansen, T. S., Galougahi, K. K., Tang, O., Tsang, M., Scherrer-Crosbie, M., Arystarkhova, E., . . . Figtree, G. A. (2024). The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H623-H635.
2024 Wong, N. K. P., Solly, E. L., Le, R., Nankivell, V. A., Mulangala, J., Psaltis, P. J., . . . Tan, J. T. M. (2024). TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis. International Journal of Molecular Sciences, 25(6), 16 pages.
2024 Goudiaby, H., Roca-Rada, X., Kassdjikova, K., Fehren-Schmitz, L., & Llamas, B. (2024). Biological sex estimation using ancient DNA in Classic Maya contexts: some findings from Naachtun (Guatemala) = Estimation du sexe biologique au moyen de l’ADN ancien en contexte Maya classique : un aperçu depuis Naachtun (Guatemala). Bulletins et Mémoires de la Société d'anthropologie de Paris, 36(1), 79-95.
2024 Dhungana, G., Nepal, R., Houtak, G., Bouras, G., Vreugde, S., & Malla, R. (2024). Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli. International Microbiology.
Scopus12024 Eltweri, A. M., Basamh, M., Ting, Y. Y., Harris, M., Garcea, G., & Kuan, L. L. (2024). A retrospective multicentre clinical study on management of isolated splenic vein thrombosis: risks and benefits of anticoagulation. Langenbeck's Archives of Surgery, 409(1), 6 pages.
2024 Hbeilini, G., & Dmello, J. (2024). The Rise of #Cartels: Exploring the Organizational Operations and Messaging of Public Perception on Twitter. Journal of Applied Security Research, 1-29.
2024 Wood, T. C., Maqsood, S., Saunders, A., Sancha, W., Nanavaty, M. A., Wearne, M., & Rajak, S. (2024). Simulation-based training for intraoperative posterior capsule rupture management: an analysis of nontechnical skills development and the relationship between technical and nontechnical skills. Eye (Basingstoke), 38(10), 1958-1963.
2024 Quader, S., Ako, R. T., Sriram, S., Fumeaux, C., & Withayachumnankul, W. (2024). Mechanically Reconfigurable Polarization Converter for Terahertz Waves. IEEE Transactions on Terahertz Science and Technology, 14(4), 502-509.
2024 Lee, D., Arnold, M., Srivastava, A., Plastow, K., Strelan, P., Ploeckl, F., . . . Palmer, E. (2024). The impact of generative AI on higher education learning and teaching: A study of educators’ perspectives. Computers and Education: Artificial Intelligence, 6, 100221.
Scopus102024 Nankivell, V., Vidanapathirana, A. K., Hoogendoorn, A., Tan, J. T. M., Verjans, J., Psaltis, P. J., . . . Bursill, C. A. (2024). Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease. Cardiovascular Research, 120(8), 819-838.
Scopus3 Europe PMC12023 Cartland, S. P., Stanley, C. P., Bursill, C., Passam, F., Figtree, G. A., Patel, S., . . . Kavurma, M. M. (2023). Sex, Endothelial Cell Functions, and Peripheral Artery Disease. International Journal of Molecular Sciences, 24(24), 17439-1-17439-14.
Scopus4 Europe PMC32023 Bursill, C. A. (2023). NDRG1: A New Regulator of Vascular Inflammation and Atherothrombosis. Circulation Research, 132(3), 320-322.
2023 Schwarz, N., Fernando, S., Chen, Y. -C., Salagaras, T., Rao, S. R., Liyanage, S., . . . Psaltis, P. J. (2023). Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation. The FASEB Journal, 37(4), 1-20.
Scopus14 WoS2 Europe PMC52023 Zhu, W., Xie, Z., Chu, Z., Ding, Y., Shi, G., Chen, W., . . . Tian, B. (2023). The Chromatin Remodeling Factor BrCHR39 Targets DNA Methylation to Positively Regulate Apical Dominance in Brassica rapa. Plants, 12(6), 15 pages.
Scopus1 Europe PMC12023 Wang, X., Xie, Z., Tian, Z., Wang, S., Shi, G., Chen, W., . . . Wei, F. (2023). BrDMC1, a Recombinase Gene, Is Involved in Seed Germination in Brassica rapa under Salt Stress. Agronomy, 13(2), 15 pages.
2022 Staikopoulos, V., Zhang, X., Pullen, B. P., Reineck, P., Vidanapathirana, A. K., Lee, S. M., . . . Abell, A. D. (2022). Multi-coloured fluorescent sensing toolbox for selective detection of nitroxyl <i>in vitro</i> and <i>ex vivo</i>. Sensors & Diagnostics, 1(2), 280-293.
Scopus1 WoS12022 Kavurma, M. M., Bursill, C., Stanley, C. P., Passam, F., Cartland, S. P., Patel, S., . . . Robinson, D. A. (2022). Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease. Frontiers in Cardiovascular Medicine, 9, 1-15.
Scopus17 Europe PMC122022 Fernando, S., Salagaras, T., Schwarz, N., Sandeman, L., Tan, J. T. M., Xie, J., . . . Psaltis, P. J. (2022). Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36. The FASEB Journal, 36(2), 1-19.
Scopus3 WoS3 Europe PMC12022 Li, J., Thiele, S., Kirk, R. W., Quirk, B. C., Hoogendoorn, A., Chen, Y. C., . . . McLaughlin, R. A. (2022). 3D-printed micro lens-in-lens for in vivo multimodal microendoscopy. Small, 18(17), 2107032-1-2107032-8.
Scopus37 WoS13 Europe PMC92022 Agbaedeng, T. A., Zacharia, A. L., Iroga, P. E., Rathnasekara, V. M., Munawar, D. A., Bursill, C., & Noubiap, J. J. (2022). Associations between adipokines and atrial fibrillation: A systematic review and meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 32(4), 853-862.
Scopus7 WoS5 Europe PMC42022 Clare, J., Ganly, J., Bursill, C. A., Sumer, H., Kingshott, P., & de Haan, J. B. (2022). The mechanisms of restenosis and relevance to next generation stent design. Biomolecules, 12(3), 430-1-430-26.
Scopus30 WoS8 Europe PMC152022 Mulangala, J., Akers, E. J., Solly, E. L., Bamhare, P. M., Wilsdon, L. A., Wong, N. K. P., . . . Di Bartolo, B. A. (2022). Pro-Calcific Environment Impairs Ischaemia-Driven Angiogenesis.. International journal of molecular sciences, 23(6), 1-21.
2022 Stanton, K. M., Liu, H., Kienzle, V., Bursill, C., Bao, S., & Celermajer, D. S. (2022). The Effects of Exercise on Plaque Volume and Composition in a Mouse Model of Early and Late Life Atherosclerosis. Frontiers in Cardiovascular Medicine, 9, 1-10.
Scopus4 WoS3 Europe PMC22022 Vidanapathirana, A. K., Goyne, J. M., Williamson, A. E., Pullen, B. J., Chhay, P., Sandeman, L., . . . Bursill, C. A. (2022). Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor. Biomedicines, 10(8), 1807.
Scopus7 WoS2 Europe PMC32022 Bursill, C. A., Smith, N. J., Palpant, N., Tan, I., Sunde, M., Harvey, R. P., . . . Australian Cardiovascular Alliance. (2022). Don't Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future.. Heart, lung & circulation, 31(10), S1443-9506(22)00976-3.
Scopus1 Europe PMC12022 Li, J., Montarello, N., Hoogendoorn, A., Verjans, J., Bursill, C., Peter, K., . . . Psaltis, P. (2022). Multimodality intravascular imaging of high-risk coronary plaque. JACC: Cardiovascular Imaging, 15(1), 145-159.
Scopus41 WoS22 Europe PMC222021 Nankivell, V. A., Tan, J. T. M., Wilsdon, L. A., Morrison, K. R., Bilu, C., Psaltis, P. J., . . . Brown, A. (2021). Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus. Scientific reports, 11(1), 1-13.
Scopus13 WoS7 Europe PMC72021 Watts, G. F., Sullivan, D. R., Hare, D. L., Kostner, K. M., Horton, A. E., Bell, D. A., . . . Psaltis, P. (2021). Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians.. Intern Med J, 51(5), 769-779.
Scopus6 WoS3 Europe PMC32021 Watts, G. F., Sullivan, D. R., Hare, D. L., Kostner, K. M., Horton, A. E., Bell, D. A., . . . Pang, J. (2021). Synopsis of an Integrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia: an Australian Perspective. American Journal of Preventive Cardiology, 6, 100151-1-100151-9.
Scopus3 WoS2 Europe PMC22021 Hoogendoorn, A., Avery, T. D., Li, J., Bursill, C., Abell, A., & Grace, P. M. (2021). Emerging therapeutic applications for fumarates. Trends in Pharmacological Sciences, 42(4), 239-254.
Scopus19 WoS12 Europe PMC132021 Morrison, K. R., Solly, E. L., Shemesh, T., Psaltis, P. J., Nicholls, S. J., Brown, A., . . . Tan, J. T. M. (2021). Elevated HDL-bound miR-181c-5p level is associated with diabetic vascular complications in Australian Aboriginal people. Diabetologia, 64(6), 1402-1411.
Scopus14 WoS11 Europe PMC132021 Pisaniello, A. D., Psaltis, P. J., King, P. M., Liu, G., Gibson, R. A., Tan, J. T. M., . . . Di Bartolo, B. A. (2021). Omega-3 fatty acids ameliorate vascular inflammation: a rationale for their atheroprotective effects. Atherosclerosis, 324, 27-37.
Scopus29 WoS22 Europe PMC162021 Ravindran, D., Galougahi, K. K., Tan, J. T. M., Kavurma, M. M., & Bursill, C. A. (2021). The Multiple Roles of Chemokines in the Mechanisms of Stent Biocompatibility.. Cardiovasc Res, 117(11), 2299-2308.
Scopus5 Europe PMC22021 Vidanapathirana, A. K., Psaltis, P. J., Bursill, C. A., Abell, A. D., & Nicholls, S. J. (2021). Cardiovascular bioimaging of nitric oxide: achievements, challenges, and the future. Medicinal research reviews, 41(1), 435-463.
Scopus25 WoS16 Europe PMC102021 Solly, E. L., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2021). The Role of miR-181c in Mechanisms of Diabetes-Impaired Angiogenesis: An Emerging Therapeutic Target for Diabetic Vascular Complications. Frontiers in Pharmacology, 12, 718679-1-718679-16.
Scopus16 WoS6 Europe PMC72020 Lotfollahi, Z., Dawson, J., Fitridge, R., & Bursill, C. (2020). The anti-inflammatory and pro-angiogenic properties of high-density lipoproteins (HDL): an emerging role in diabetic wound healing.. Adv Wound Care (New Rochelle), 10(7), 370-380.
Scopus12 WoS8 Europe PMC72020 Watts, G. F., Sullivan, D. R., Hare, D. L., Kostner, K. M., Horton, A. E., Bell, D. A., . . . FH Australasia Network Consensus Working Group. (2020). Integrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia in Australia.. Heart Lung Circ, 30(3), 324-349.
Scopus69 WoS45 Europe PMC312020 Li, J., Thiele, S., Quirk, B. C., Kirk, R. W., Verjans, J. W., Akers, E., . . . McLaughlin, R. A. (2020). Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use. Light: Science and Applications, 9(1), 124-1-124-10.
Scopus111 WoS56 Europe PMC222020 Primer, K. R., Psaltis, P. J., Tan, J. T. M., & Bursill, C. A. (2020). The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis.. Int J Mol Sci, 21(10), 1-21.
Scopus22 WoS16 Europe PMC172020 Khalid, A., Bai, D., Abraham, A. N., Jadhav, A., Linklater, D., Matusica, A., . . . Gibson, B. C. (2020). Electrospun nanodiamond-silk fibroin membranes: a multifunctional platform for biosensing and wound-healing applications. ACS Appl Mater Interfaces, 12(43), 48408-48419.
Scopus57 WoS33 Europe PMC182020 Li, J., Thiele, S., Quirk, B. C., Kirk, R. W., Verjans, J. W., Akers, E., . . . McLaughlin, R. A. (2020). Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use.. Light, science & applications, 9(1), 124.
2019 Takata, K., Honda, S., Sidharta, S. L., MyNgan, D., Shishikura, D., Kim, S. W., . . . Nicholls, S. J. (2019). Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy. CARDIOVASCULAR DIAGNOSIS AND THERAPY, 9(4), 310.
Scopus8 WoS7 Europe PMC62019 Liu, G., Bursill, C., Cartland, S. P., Anwer, A. G., Parker, L. M., Zhang, K., . . . Goldys, E. M. (2019). A nanoparticle-based affinity sensor that identifies and selects highly cytokine-secreting cells. iScience, 20, 137-147.
Scopus16 WoS13 Europe PMC72019 Ravindran, D., Cartland, S. P., Bursill, C. A., & Kavurma, M. M. (2019). Broad-spectrum chemokine inhibition blocks inflammation-induced angiogenesis, but preserves ischemia-driven angiogenesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13423-13434.
Scopus5 WoS4 Europe PMC32019 Tan, J. T. M., Nankivell, V. A., Bilu, C., Shemesh, T., Nicholls, S. J., Zimmet, P., . . . Bursill, C. A. (2019). High-Energy Diet and Shorter Light Exposure Drives Markers of Adipocyte Dysfunction in Visceral and Subcutaneous Adipose Depots of Psammomys obesus.. Int J Mol Sci, 20(24), 17 pages.
Scopus11 WoS8 Europe PMC92019 Solly, E. L., Dimasi, C. G., Bursill, C. A., Psaltis, P. J., & Tan, J. T. M. (2019). MicroRNAs as therapeutic targets and clinical biomarkers in atherosclerosis. Journal of Clinical Medicine, 8(12), 2199-1-2199-26.
Scopus47 WoS41 Europe PMC282019 Vidanapathirana, A. K., Pullen, B. J., Zhang, R., Duong, M. N., Goyne, J. M., Zhang, X., . . . Psaltis, P. J. (2019). A novel ruthenium-based molecular sensor to detect endothelial nitric oxide. Scientific Reports, 9(1), 1720-1-1720-16.
Scopus9 WoS5 Europe PMC42019 Yuan, J., Tan, J. T. M., Rajamani, K., Solly, E. L., King, E. J., Lecce, L., . . . Ng, M. K. C. (2019). Fenofibrate rescues diabetes-related impairment of ischemia-mediated angiogenesis by PPARα-independent modulation of thioredoxin-interacting protein. Diabetes, 68(5), 1040-1053.
Scopus19 WoS15 Europe PMC122019 Toledo-Flores, D., Williamson, A., Schwarz, N., Fernando, S., Dimasi, C., Witt, T. A., . . . Psaltis, P. J. (2019). Vasculogenic properties of adventitial Sca-1⁺CD45⁺ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis. Scientific Reports, 9(1), 7286-1-7286-15.
Scopus17 WoS15 Europe PMC72019 MacEr-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S., & Hawkins, C. L. (2019). A role for chlorinated nucleosides in the perturbation of macrophage function and promotion of inflammation. Chemical Research in Toxicology, 32(6), 1223-1234.
Scopus13 WoS6 Europe PMC42019 Nguyen, M. T., Fernando, S., Schwarz, N., Tan, J. T. M., Bursill, C. A., & Psaltis, P. J. (2019). Inflammation as a therapeutic target in atherosclerosis. Journal of Clinical Medicine, 8(8), 1109-1-1109-20.
Scopus140 WoS99 Europe PMC712018 Ridiandries, A., Tan, J. T. M., & Bursill, C. A. (2018). The role of chemokines in wound healing. International Journal of Molecular Sciences, 19(10), 20 pages.
Scopus300 WoS209 Europe PMC1782018 Wong, N., Nicholls, S., Tan, J., & Bursill, C. (2018). The role of high-density lipoproteins in diabetes and its vascular complications. International Journal of Molecular Sciences, 19(6), 21 pages.
Scopus48 WoS29 Europe PMC352018 Wong, N. K. P., Cheung, H., Solly, E. L., Vanags, L. Z., Ritchie, W., Nicholls, S. J., . . . Tan, J. T. M. (2018). Exploring the roles of CREBRF and TRIM2 in the regulation of angiogenesis by high-density lipoproteins. International Journal of Molecular Sciences, 19(7), 1903-1-1903-17.
Scopus13 WoS13 Europe PMC92018 Clayton, Z., Tan, R., Miravet, M., Lennartsson, K., Cooke, J., Bursill, C., . . . Patel, S. (2018). Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Bioscience Reports, 38(4), BSR20180563-1-BSR20180563-11.
Scopus54 WoS40 Europe PMC292018 Hourigan, S. T., Solly, E. L., Nankivell, V. A., Ridiandries, A., Weimann, B., Henriquez, R., . . . Tan, J. T. M. (2018). The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis. Scientific Reports, 8(1), 13596.
Scopus22 WoS13 Europe PMC172018 Duong, M., Uno, K., Nankivell, V., Bursill, C., & Nicholls, S. (2018). Induction of obesity impairs reverse cholesterol transport in ob/ob mice. PLoS ONE, 13(9), 17 pages.
Scopus21 WoS11 Europe PMC112018 Di Bartolo, B., Psaltis, P., Bursill, C., & Nicholls, S. (2018). Translating evidence of HDL and plaque regression. Arteriosclerosis, thrombosis, and vascular biology, 38(9), 1961-1968.
Scopus19 WoS20 Europe PMC122018 Vanags, L. Z., Wong, N. K. P., Nicholls, S. J., & Bursill, C. A. (2018). High-density lipoproteins and apolipoprotein A-I improve stent biocompatibility: recent evidence from experimental models and clinical studies. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(8), 1691-1701.
Scopus14 WoS9 Europe PMC112018 Cannizzo, C. M., Adonopulos, A. A., Solly, E. L., Ridiandries, A., Vanags, L. Z., Mulangala, J., . . . Tan, J. T. (2018). VEGFR2 is activated by high-density lipoproteins and plays a key role in the proangiogenic action of HDL in ischemia. FASEB Journal, 32(6), 2911-2922.
Scopus10 WoS8 Europe PMC82018 Chen, X., Duong, M., Nicholls, S., & Bursill, C. (2018). Myeloperoxidase modification of high-density lipoprotein suppresses human endothelial cell proliferation and migration via inhibition of ERK1/2 and Akt activation. Atherosclerosis, 273, 75-83.
Scopus10 WoS8 Europe PMC52018 Vanags, L. Z., Tan, J. T. M., Galougahi, K. K., Schaefer, A., Wise, S. G., Murphy, A., . . . Bursill, C. A. (2018). Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype. JACC: Basic to Translational Science, 3(2), 200-209.
Scopus17 WoS12 Europe PMC132018 Morton, J., Bao, S., Vanags, L., Tsatralis, T., Ridiandries, A., Siu, C., . . . Bursill, C. (2018). Strikingly different atheroprotective effects of apolipoprotein A-I in early- versus late-stage atherosclerosis. JACC: Basic to Translational Science, 3(2), 187-199.
Scopus16 WoS11 Europe PMC142017 Chen, X., Duong, M., Psaltis, P., Bursill, C., & Nicholls, S. (2017). High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes. Cardiovascular Diabetology, 16(1), 121-1-121-9.
Scopus17 WoS16 Europe PMC162017 Chalmers, A., Bursill, C., & Myerscough, M. (2017). Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL) in plaque regression. PLoS ONE, 12(11), e0187674-1-e0187674-23.
Scopus34 WoS19 Europe PMC142017 Chung, R., Wang, Z., Bursill, C., Wu, B., Barter, P., & Rye, K. (2017). Effect of long-term dietary sphingomyelin supplementation on atherosclerosis in mice. PLoS ONE, 12(12), 1-13.
Scopus31 WoS20 Europe PMC112017 Vanags, L. Z., Tan, J. T. M., Santos, M., Michael, P. S., Ali, Z., Bilek, M. M. M., . . . Bursill, C. A. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(7), 2141-2150.
Scopus8 WoS7 Europe PMC42017 Ridiandries, A., Bursill, C., & Tan, J. (2017). Broad-spectrum inhibition of the CC-chemokine class improves wound healing and wound angiogenesis. International Journal of Molecular Sciences, 18(1), 155-1-155-15.
Scopus30 WoS23 Europe PMC152017 Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L., . . . Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. FASEB Journal, 31(3), 1179-1192.
Scopus14 WoS12 Europe PMC132017 van der Vorst, E., Theodorou, K., Wu, Y., Hoeksema, M., Goossens, P., Bursill, C., . . . Donners, M. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. Cell Metabolism, 25(1), 197-207.
Scopus89 WoS55 Europe PMC622017 Tan, J. T. M., Prosser, H. C. G., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T., . . . Bursill, C. A. (2017). High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I (vol 65, pg 3091, 2016). DIABETES, 66(4), 1 page.
Europe PMC12017 Ravindran, D., Ridiandries, A., Vanags, L., Henriquez, R., Cartland, S., Tan, J., & Bursill, C. (2017). Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. PLoS ONE, 12(3), e0173224-1-e0173224-23.
Scopus17 WoS14 Europe PMC102017 Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M., . . . Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. PLoS ONE, 12(3), e0174773-1-e0174773-15.
Scopus19 WoS15 Europe PMC112016 Arnott, C., Punnia-Moorthy, G., Tan, J., Sadeghipour, S., Bursill, C., & Patel, S. (2016). The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells. PLOS ONE, 11(3), e0150688.
Scopus22 WoS23 Europe PMC152016 Ridiandries, A., Tan, J., & Bursill, C. (2016). The role of CC-chemokines in the regulation of angiogenesis. International Journal of Molecular Sciences, 17(11), 1856-1-1856-16.
Scopus87 WoS70 Europe PMC632016 Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L., Lam, Y., Tan, J. T., . . . Bursill, C. (2016). Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15(1), 150-1-150-12.
Scopus16 WoS8 Europe PMC92016 Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T., . . . Bursill, C. (2016). High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor Class B Type I. Diabetes, 65(10), 3091-3103.
Scopus37 WoS27 Europe PMC282016 Lam, Y., Lecce, L., Tan, J., Bursill, C., Handelsman, D., & Ng, M. (2016). Androgen receptor-mediated genomic androgen action augments ischemia-induced neovascularization. Endocrinology, 157(12), 4853-4864.
Scopus8 WoS6 Europe PMC52016 Robertson, S., Martínez, G., Payet, C., Barraclough, J., Celermajer, D., Bursill, C., & Patel, S. (2016). Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation. Clinical Science, 130(14), 1237-1246.
Scopus126 WoS92 Europe PMC612015 Martínez, G., Robertson, S., Barraclough, J., Xia, Q., Mallat, Z., Bursill, C., . . . Patel, S. (2015). Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome. Journal of the American Heart Association, 4(8), e002128-1-e002128-10.
Scopus232 WoS194 Europe PMC1202015 Chalmers, A., Cohen, A., Bursill, C., & Myerscough, M. (2015). Bifurcation and dynamics in a mathematical model of early atherosclerosis: how acute inflammation drives lesion development. Journal of Mathematical Biology, 71(6), 1451-1480.
Scopus44 WoS26 Europe PMC172015 Kim, C., Mitchell, J., Bursill, C., Sowers, A., Thetford, A., Cook, J., . . . Davies, M. (2015). The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE¯⁄¯mice. Atherosclerosis, 240(1), 234-241.
Scopus47 WoS38 Europe PMC232015 Tan, J., Ng, M., & Bursill, C. (2015). The role of high-density lipoproteins in the regulation of angiogenesis. Cardiovascular Research, 106(2), 184-193.
Scopus36 WoS29 Europe PMC252014 Dunn, L., Simpson, P., Prosser, H., Lecce, L., Yuen, G., Buckle, A., . . . Ng, M. (2014). A critical role for Thioredoxin- Interacting protein in diabetes-related impairment of angiogenesis. Diabetes, 63(2), 675-687.
Scopus57 WoS51 Europe PMC422014 Brown, B., Kim, C., Torpy, F., Bursill, C., McRobb, L., Heather, A., . . . Van Reyk, D. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E-/- mice. Atherosclerosis, 232(2), 403-409.
Scopus55 WoS50 Europe PMC352014 Prosser, H., Tan, J., Dunn, L., Patel, S., Vanags, L., Bao, S., . . . Bursill, C. (2014). Multifunctional regulation of angiogenesis by high-density lipoproteins. Cardiovascular Research, 101(1), 145-154.
Scopus43 WoS38 Europe PMC332014 Tan, J., Hamish, H., Vanags, L., Monger, S., Ng, M., & Bursill, C. (2014). High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α. FASEB Journal, 28(1), 206-217.
Scopus51 WoS42 Europe PMC392013 Van Der Vorst, E., Vanags, L., Dunn, L., Prosser, H., Rye, K., & Bursill, C. (2013). High-density lipoproteins suppress chemokine expression and proliferation in human vascular smooth muscle cells. FASEB Journal, 27(4), 1413-1425.
Scopus46 WoS39 Europe PMC342013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M., & Bursill, C. (2013). Murine model of wound healing. Journal of Visualized Experiments, 2013(75), 1-6.
Scopus201 WoS156 Europe PMC872013 Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M., & Bursill, C. (2013). Murine model of wound healing. Journal of visualized experiments : JoVE, (75), e50265.
Scopus442013 Ali, Z. A., Rinze, R., Douglas, G., Hu, Y., Xiao, Q., Qi, W., . . . Channon, K. M. (2013). Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration. Circulation, 128(SUPPL.1), S50-S58.
Scopus20 WoS17 Europe PMC132012 Prosser, H., Ng, M., & Bursill, C. (2012). The role of cholesterol efflux in mechanisms of endothelial protection by HDL. Current Opinion in Lipidology, 23(3), 182-189.
Scopus56 WoS51 Europe PMC432011 Akram, O. N., Bursill, C., Desai, R., Heather, A. K., Kazlauskas, R., Handelsman, D. J., & Lambert, G. (2011). Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays. Analytical Chemistry, 83(6), 2065-2074.
Scopus43 WoS37 Europe PMC192011 Di Bartolo, B., Vanags, L., Tan, J., Bao, S., Rye, K., Barter, P., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit.. Lipids in health and disease, 10(1), 224.
Scopus28 WoS24 Europe PMC162011 Di Bartolo, B., Nicholls, S., Bao, S., Rye, K., Heather, A., Barter, P., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins. Atherosclerosis, 217(2), 395-400.
Scopus58 WoS52 Europe PMC452010 Bursill, C. A., Castro, M. L., Beattie, D. T., Nakhla, S., Van Der Vorst, E., Heather, A. K., . . . Rye, K. A. (2010). High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(9), 1773-1778.
Scopus112 WoS104 Europe PMC862009 Rye, K. A., Bursill, C. A., Lambert, G., Tabet, F., & Barter, P. J. (2009). The metabolism and anti-atherogenic properties of HDL. Journal of Lipid Research, 50(SUPPL.), S195-S200.
Scopus247 WoS229 Europe PMC1622009 Seki, E., De Minicis, S., Gwak, G. Y., Kluwe, J., Inokuchi, S., Bursill, C. A., . . . Schwabe, R. F. (2009). CCR1 and CCR5 promote hepatic fibrosis in mice. Journal of Clinical Investigation, 119(7), 1858-1870.
Scopus386 WoS339 Europe PMC2792009 Bursill, C. A., McNeill, E., Wang, L., Hibbitt, O. C., Wade-Martins, R., Paterson, D. J., . . . Channon, K. M. (2009). Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition. Gene Therapy, 16(1), 93-102.
Scopus32 WoS31 Europe PMC222009 Stevenson, N. J., Addley, M. R., Ryan, E. J., Boyd, C. R., Carroll, H. P., Paunovic, V., . . . Johnston, J. A. (2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. Journal of Leukocyte Biology, 85(2), 289-297.
Scopus30 WoS29 Europe PMC212008 McAteer, M. A., Schneider, J. E., Ali, Z. A., Warrick, N., Bursill, C. A., Von Zur Muhlen, C., . . . Choudhury, R. P. (2008). Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(1), 77-83.
Scopus227 WoS202 Europe PMC1372008 Ali, Z. A., Bursill, C. A., Douglas, G., McNeil, E., Papaspyridonos, M., Tatham, A. L., . . . Channon, K. M. (2008). CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis. Circulation, 118(14 Suppl), S71-S77.
2007 Bursill, C. A., & Roach, P. D. (2007). A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Lipids, 42(7), 621-627.
Scopus47 WoS48 Europe PMC232007 Hibbitt, O. C., Harbottle, R. P., Waddington, S. N., Bursill, C. A., Coutelle, C., Channon, K. M., & Wade-Martins, R. (2007). Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection. Journal of Gene Medicine, 9(6), 488-497.
Scopus40 WoS35 Europe PMC252007 Bursill, C. A., Abbey, M., & Roach, P. D. (2007). A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis, 193(1), 86-93.
Scopus123 WoS97 Europe PMC542006 Bursill, C. A., & Roach, P. D. (2006). Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. Journal of Agricultural and Food Chemistry, 54(5), 1621-1626.
Scopus86 WoS75 Europe PMC422006 Ali, T., Humphries, J., Burnand, K., Sawyer, B., Bursill, C., Channon, K., . . . Smith, A. (2006). Monocyte recruitment in venous thrombus resolution. Journal of Vascular Surgery, 43(3), 601-608.
Scopus74 WoS66 Europe PMC552006 Bursill, C. A., Cash, J. L., Channon, K. M., & Greaves, D. R. (2006). Membrane-bound CC chemokine inhibitor 35k provides localized inhibition of CC chemokine activity in vitro and in vivo. Journal of Immunology, 177(8), 5567-5573.
Scopus16 WoS15 Europe PMC102005 Ali, Z. A., Bursill, C. A., Hu, Y., Choudhury, R. P., Xu, Q., Greaves, D. R., & Channon, K. M. (2005). Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice. Circulation, 112(9 SUPPL.), I235-I241.
Scopus40 WoS34 Europe PMC212005 Puhakka, H. L., Turunen, P., Gruchala, M., Bursill, C., Heikura, T., Vajanto, I., . . . Ylä-Herttuala, S. (2005). Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits. In Vivo, 19(3), 515-522.
Scopus21 WoS18 Europe PMC102004 Bursill, C. A., Channon, K. M., & Greaves, D. R. (2004). The role of chemokines in atherosclerosis: Recent evidence from experimental models and population genetics. Current Opinion in Lipidology, 15(2), 145-149.
Scopus98 WoS87 Europe PMC782004 Bursill, C. A., Choudhury, R. P., Ali, Z., Greaves, D. R., & Channon, K. M. (2004). Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice. Circulation, 110(16), 2460-2466.
Scopus64 WoS62 Europe PMC442003 Lucas, A. D., Bursill, C., Guzik, T. J., Sadowski, J., Channon, K. M., & Greaves, D. R. (2003). Smooth Muscle Cells in Human Atherosclerotic Plaques Express the Fractalkine Receptor CX<inf>3</inf>CR1 and Undergo Chemotaxis to the CX <inf>3</inf>C Chemokine Fractalkine (CX<inf>3</inf>CL1). Circulation, 108(20), 2498-2504.
Scopus148 WoS137 Europe PMC1032003 Bursill, C. A., Cai, S., Channon, K. M., & Greaves, D. R. (2003). Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo. Immunobiology, 207(3), 187-196.
Scopus35 WoS35 Europe PMC202001 Bursill, C., Roach, P., Bottema, C., & Pal, S. (2001). Green tea upregulates the low-density lipoprotein receptor through the sterol-regulated element binding protein in HepG2 liver cells. Journal of Agricultural and Food Chemistry, 49(11), 5639-5645.
Scopus58 WoS43 Europe PMC21- Lotfollahi, Z., Tan, J. T. M., Nankivell, V. A., Sandeman, L., Liyanage, S., Solly, E. L., . . . Bursill, C. A. (n.d.). Topical Reconstituted High-Density Lipoproteins Elicit Anti-Inflammatory Effects in Diabetic Wounds. ADVANCES IN WOUND CARE, 16 pages.
-
Book Chapters
Year Citation 2020 Nankivell, V., Primer, K., Vidanapathirana, A., Psaltis, P., & Bursill, C. (2020). Vascular Biology of Smooth Muscle Cells and Restenosis. In R. Fitridge (Ed.), Mechanisms of Vascular Disease A Textbook for Vascular Specialists (3rd ed., pp. 117-139). Cham, Switzerland: Springer. -
Conference Papers
Year Citation 2023 Liyanage, S., Williamson, A., Salagaras, T., Hassanshahi, M., Long, A., Tran, D., . . . Psaltis, P. (2023). Inhibitory And Metabolic Effects Of Diabetes On Yolk Sacderived Endothelial-macrophage Progenitors In Postnatal Murine Tissues. In ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Vol. 43 (pp. 2 pages). PA, Philadelphia: LIPPINCOTT WILLIAMS & WILKINS.
DOI2022 Solly, E. L., Mulangala, J., Di Bartolo, B. A., Nicholls, S. J., Psaltis, P. J., Bursill, C. A., & Tan, J. T. M. (2022). Inhibition of microRNA-181c rescues diabetes-impaired angiogenesis through activation of key angiogenesis mediators. In DIABETOLOGIA Vol. 65 (pp. S25-S26). Stockholm, SWEDEN: SPRINGER. 2020 Cannizzo, C., Solly, E., Olaya, L. F., Abdollahi, M., Sutanto, S. S., Twigg, S. M., . . . Mclennan, S. (2020). Inhibition of miRNA-200b Rescues Diabetes-Impaired Angiogenesis. In DIABETES Vol. 69 (pp. 2 pages). ELECTR NETWORK: AMER DIABETES ASSOC.
DOI2019 Khalid, A., Abraham, A. N., Bai, D., Jadhav, A., Linklater, D., Nguyen, D., . . . Gibson, B. (2019). Electrospun diamond-silk membranes for biosensing applications. In Proceedings of SPIE - The International Society for Optical Engineering Vol. 11202 (pp. 1-5). online: SPIE.
DOI Scopus1 WoS12019 Pisaniello, A. D., King, P., Di Bartolo, B. A., Liu, G., Gibson, R. A., Tan, J. T. M., . . . Nicholls, S. (2019). IMPACT OF FISH OIL SUPPLEMENTATION ON ACUTE VASCULAR INFLAMMATION IN HEALTHY VOLUNTEERS. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 73 (pp. 2091). New Orleans, LA: ELSEVIER SCIENCE INC.
DOI2017 Cannizzo, C. M., Adonopulos, A. A., Ridiandries, A., Vanags, L. Z., Yuen, S. C. G., Tsatralis, T., . . . Tan, J. T. (2017). VEGFR2 is Activated by High-Density Lipoproteins and Plays a Key Role in the Pro-Angiogenic Action of HDL in Ischemia. In CIRCULATION Vol. 136 (pp. 1 page). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS. 2017 Hourigan, S. T., Ridiandries, A., Tepper, E. R., Zhang, J. Q., Henriquez, R., Tsatralis, T., . . . Tan, J. T. (2017). The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. In CIRCULATION Vol. 136 (pp. 1 page). Anaheim, CA: LIPPINCOTT WILLIAMS & WILKINS. 2017 Van Der Vorst, E., Theodorou, K., Wu, Y., Hoeksema, M., Goossens, P., Bursill, C., . . . Donners, M. (2017). HIGH DENSITY LIPOPROTEINS EXERT PRO-INFLAMMATORY EFFECTS ON MACROPHAGES VIA PASSIVE CHOLESTEROL DEPLETION AND PKC-NF-KB/STAT1-IRF1 SIGNALING. In ATHEROSCLEROSIS Vol. 263 (pp. E6). Prague, CZECH REPUBLIC: ELSEVIER IRELAND LTD.
DOI WoS12008 Ali, Z. A., Bursill, C. A., Douglas, G., McNeill, E., Papaspyridonos, M., Tatham, A. L., . . . Channon, K. M. (2008). CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.. In Circulation Vol. 118 (pp. S71-S77). Orlando, FL: LIPPINCOTT WILLIAMS & WILKINS.
DOI Scopus31 WoS30 Europe PMC19 -
Conference Items
Year Citation 2022 Nankivell, V. A., Vidanapathirana, A., Rajora, M., Psaltis, P., Tan, J. T., Tieu, W., . . . Bursill, C. A. (2022). Theranostic Properties of Porphysome Nanoparticles in Atherosclerotic Cardiovascular Disease. Poster session presented at the meeting of CIRCULATION. Chicago, IL: LIPPINCOTT WILLIAMS & WILKINS. 2022 Primer, K. R., Tan, J. T., Psaltis, P. J., & Bursill, C. A. (2022). Pyruvate Dehydrogenase Kinase 4 is a Novel Regulator of Endothelial Cell Mitochondrial Respiration in Diabetes-Impaired Angiogenesis: Implications for Preventing Diabetic Vascular Complications. Poster session presented at the meeting of CIRCULATION. Chicago, IL: LIPPINCOTT WILLIAMS & WILKINS. 2022 Lotfollahi, Z., Tan, J. T., Dawson, J., Fitridge, R., & Bursill, C. A. (2022). Tracking High-Density Lipoprotein Functionality in Diabetic and Non-Diabetic Patients With Toe Amputations. Poster session presented at the meeting of CIRCULATION. Chicago, IL: LIPPINCOTT WILLIAMS & WILKINS. 2022 Pullen, B. J., Vidanapathirana, A. K., Sandeman, L., Everest-Dass, A., Kolarich, D., Tan, J. T., . . . Bursill, C. A. (2022). Deletion of the Asialyloglycoprotein Receptor-1 Causes Athero-Protective Effects in vitro and in vivo. Poster session presented at the meeting of CIRCULATION. Chicago, IL: LIPPINCOTT WILLIAMS & WILKINS. 2019 Fernando, S., Schwarz, N., Sandeman, L., Skoumbourdis, T., Zareh, J., Williamson, A., . . . Psaltis, P. J. (2019). Eukaryotic Elongation Factor 2 Kinase Regulates Cholesterol Uptake by Macrophages via Cd36 Scavenger Receptor Expression. Poster session presented at the meeting of CIRCULATION. Philadelphia, PA: LIPPINCOTT WILLIAMS & WILKINS. 2019 Wong, N. K., Solly, E., Nicholls, S., Psaltis, P., Ng, M. K., Bursill, C. A., & Tan, J. T. (2019). <i>TRIM2</i> an<i>d CREBRF</i> Are Novel Regulators of Angiogenic Functions in Human Coronary Artery Endothelial Cells. Poster session presented at the meeting of CIRCULATION. Philadelphia, PA: LIPPINCOTT WILLIAMS & WILKINS. 2019 Akers, E. J., Mulangala, J., Wilsdon, L. A., Psaltis, P. J., Bursill, C. A., Nicholls, S. J., & Di Bartolo, B. A. (2019). Lipoproteins and Their Modified Forms Regulate Early Stage Vascular Smooth Muscle Cell Calcification. Poster session presented at the meeting of ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Boston, MA: LIPPINCOTT WILLIAMS & WILKINS. 2019 Williamson, A., Toledo, D. F., Schwarz, N., Fernando, S., Dimasi, C., Liyanage, S., . . . Psaltis, P. J. (2019). Postnatal mouse aorta contains yolk sac-derived haemangioblasts with myeloid and endothelial plasticity and vasculogenic capacity. Poster session presented at the meeting of European Heart Journal. Paris, France: Oxford University Press. 2018 Takata, K., Duong, M., Honda, S., Sidharta, S. L., Kim, S. W., Shishikura, D., . . . Nicholls, S. J. (2018). Association of Apolipoprotein C-III Distribution With Cholesterol Efflux Capacity and Coronary Plaque Burden. Poster session presented at the meeting of CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. 2018 Duong, M., Nankivell, V., Bursill, C. A., & Nicholls, S. J. (2018). Obesity Impairs Reverse Cholesterol Transport in Ob/Ob Mice.. Poster session presented at the meeting of CIRCULATION. LIPPINCOTT WILLIAMS & WILKINS. 2016 Tan, J. T., Hourigan, S. T., Zhang, J. Q., Wong, N. K., Tepper, E. R., Prosser, H. C., . . . Bursill, C. A. (2016). miRNA-181c and its putative target TRIM2 mediate the ability of high density lipoproteins to rescue diabetes-impaired angiogenesis. Poster session presented at the meeting of as published in Diabetes. New Orleans, LA: American Diabetes Association. 2015 Tan, J. T. M., Prosser, H. C. G., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T., . . . Bursill, C. A. (2015). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor-BI and Restoration of VEGF and HIF-1 alpha Stability. Poster session presented at the meeting of DIABETES. Boston, MA: AMER DIABETES ASSOC.
WoS12014 Van der Vorst, E. P. C., Theodorou, K., Plat, J., Van Eck, M., Rye, K. A., Bursill, C. A., . . . Donners, M. M. P. C. (2014). High density lipoproteins exert pro-inflammatory effects on macrophages via IKK2-and NIK-independent NF-kB activation. Poster session presented at the meeting of CARDIOVASCULAR RESEARCH. Barcelona, SPAIN: OXFORD UNIV PRESS.
DOI2013 Prosser, H. C., Tan, J. T., Dunn, L. L., Patel, S., Vanags, L. Z., Monger, S., . . . Bursill, C. A. (2013). Multifunctional Regulation of Angiogenesis by High Density Lipoproteins. Poster session presented at the meeting of CIRCULATION. Dallas, TX: LIPPINCOTT WILLIAMS & WILKINS. 2013 Morton, J., Bao, S., Celermajer, D. S., Ng, M. K., & Bursill, C. A. (2013). Strikingly Different Atheroprotective Effects of Apolipoprotein A-I in Early-Stage Versus Late-Stage Atherosclerosis. Poster session presented at the meeting of CIRCULATION. Dallas, TX: LIPPINCOTT WILLIAMS & WILKINS.
WoS12012 Quigley, A. F., Summers, F. A., Barrett, T. J., Bursill, C. A., & Hawkins, C. L. (2012). A novel role of myeloperoxidase in the induction of endoplasmic reticulum (ER) stress. Poster session presented at the meeting of FREE RADICAL BIOLOGY AND MEDICINE. ELSEVIER SCIENCE INC.
DOI2012 Quigley, A. F., Summers, F. A., Barrett, T. J., Bursill, C. A., & Hawkins, C. L. (2012). A Novel Role for Myeloperoxidase in the Induction of C/EBP-Homologous Protein (CHOP). Poster session presented at the meeting of FREE RADICAL BIOLOGY AND MEDICINE. San Diego, CA: ELSEVIER SCIENCE INC.
DOI -
Preprint
Year Citation 2024 Primer, K. R., Tan, J. T. M., Sandeman, L., Nankivell, V., Stretton, L. G., Solly, E., . . . Bursill, C. A. (2024). Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia.
DOI2024 Ruchka, P., Kushwaha, A., Marathe, J. A., Xiang, L., Chen, R., Kirk, R., . . . Li, J. (2024). 3D-printed axicon enables extended depth-of-focus intravascular optical
coherence tomography.2024 Wong, N. K. P., Solly, E., Le, R., Nankivell, V., Mulangala, J., Psaltis, P., . . . Tan, J. T. M. (2024). TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis.
DOI2024 Nankivell, V., Sandeman, L., Stretton, L., Vidanapathirana, A., Rajora, M., Chen, J., . . . Bursill, C. (2024). Multifunctional biomimetic porphyrin-lipid nanoparticles – novel nanoscale theranostics for atherosclerotic cardiovascular disease.
DOI
·National Heart Foundation Lin Huddleston Foundation Fellowship (2017-2022)
Chief Investigator: Christina Bursill (CIA)
Amount: ~$750,000 over 5 years
·Diabetes Australia Research (DART) grant (2017)
Title: ‘Micromanaging’ high-density lipoprotein-induced rescue of diabetes-impaired angiogenesis
Chief Investigators: Joanne Tan and Christina Bursill
Amount: $60,000
· NAB Career Re-start Grant (2016)
Title: Reversing the progression of atherosclerosis
Chief Investigators: Christina Bursill (CIA),
Amount: $60,000 over one year
· ARC Discovery Grant (2016)
Title: Dynamics of atherosclerotic plaque formation, growth and regression
Chief Investigators: Mary Myerscough (CIA), Charlie Macaskill (CIB), Christina Bursill (PI).
Amount: $218,768 over three years
· University of Sydney - Thompson Fellowship (2016)
Title: Using the "Good Cholesterol" to increase stent longevity
Chief Investigator: Christina Bursill (CIA)
Amount: $90, 000 over one year
· University of Sydney Bridging Grant (2015)
Title: Different athero-protective properties of HDL in early versus late atherosclerosis
Chief Investigators: Christina Bursill (CIA)
Amount: $30, 000 over 1 year
· NHMRC Project Grant (2015)
Title: Oxidative Regulation of the Na pump – a new player in vascular function in health and disease.
Chief Investigators: Gemma Figtree (CIA), Christina Bursill (CIB), A/Prof Ravinay Bhindi (CIC), Prof Keith Channon (CID), A/Prof Clare Hawkins (CIE), Dr Ben Davies (CIF), Prof Richard Cohen (CIG).
Amount: $488,816 over three years
· University of Sydney Bridging Grant (2013)
Title: Differential Regulation of Angiogenesis by CC-Chemokines
Chief Investigators: Christina Bursill (CIA)
Amount: $30, 000 over 1 year
· NHMRC project grant (2010-2013)
Title: Multifunctional regulation of Angiogenesis by High Density Lipoproteins
Chief Investigators: Martin Ng (CIA), Christina Bursill (CIB)
Amount: $476, 000 over 3 years
· Heart Foundation Career Development Fellowship (2008-2013)
Title: The Role of Chemokines in the Anti-Atherosclerotic Effects of HDL
Chief Investigator: Christina Bursill
Amount: $515,000 – includes 5 years salary, travel funds and equipment support.
·Bushell Foundation (2008-2011)
Title: Understanding the Anti-Atherosclerotic Properties of High Density Lipoproteins
Investigator: Christina Bursill
Amount: $250, 000 over 3 years
· British Heart Foundation Program Grant (2005-2007):
Title: Evaluation of Broad Spectrum Chemokine agonists to Inhibit Atherosclerosis
Investigators: Keith Channon, David Greaves, and Christina Bursill
Amount: £715,961 over 5 years
· British Heart Foundation Project Grant (2001-2004):
Title: Evaluation of Broad Spectrum CC-Chemokine antagonists to Inhibit Inflammatory Cell Recruitment in Atherogenesis.
Investigators: David Greaves, Keith Channon, and Christina Bursill
Amount: £152,326 over 3 years. Based on the success of the project, the initial grant was extended for a further 2.5 years (£126,939) based on my research.
Undergraduate Teaching:
·1997-98: Tutor for 1st year Medical students in Problem Based Learning, Department of Medicine, University of Adelaide.
·1998-2000: Demonstrator for 2nd year Science students in Cardiovascular Physiology, Department of Physiology, University of Adelaide.
·2001: Lecturer to 2nd year Medical students on Lipoprotein Metabolism, Department of Pathology, University of Oxford, UK.
·2001, 2002: Demonstrator for 2nd year Medical Students in Atherosclerosis and Thrombosis, Department of Pathology, University of Oxford, UK.
·2004-2006: Lecturer to 3rd year Medical students in ‘Methods and Approach in Scientific Research’. Department of Medicine, University of Oxford, UK.
·2015-2026: Lecturer to 3rd year Physiology students on “Vascular Inflammation”, University of Sydney, NSW.
-
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Principal Supervisor Deletion of the asialoglycoprotein receptor 1 (ASGR1) to prevent athersclerotic cardiovascular disease Doctor of Philosophy Doctorate Full Time Mr Liam George Stretton 2023 Principal Supervisor The role of the asialoglycoprotein receptor-1 in immune cell regulation of atherosclerosis Doctor of Philosophy Doctorate Full Time Mr Demeke Geremew Debebe 2023 Co-Supervisor New Predictive Factors that Drive Coronary Artery Disease Doctor of Philosophy Doctorate Full Time Miss Naomi Elizabeth Wattchow 2023 Co-Supervisor The Evaluation and Validation of Autophagy as a Novel Biomarker of Coronary Artery Disease Doctor of Philosophy Doctorate Part Time Dr Mau Tam Nguyen 2022 Co-Supervisor Multimodal imaging probe for atherosclerotic plaque detection Doctor of Philosophy Doctorate Full Time Miss Rouyan Chen -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2023 Principal Supervisor The Role of Endothelial Cell Metabolic Reprogramming in Diabetes impaired Angiogenesis Doctor of Philosophy Doctorate Full Time Miss Khalia Rose Primer 2019 - 2023 Co-Supervisor MicroRNA-181c-5p - A Novel Therapeutic Target for the Rescue of Diabetes-Impaired Angiogenesis Doctor of Philosophy Doctorate Full Time Miss Emma Louise Solly 2019 - 2023 Co-Supervisor Inhibitory and metabolic effects of diabetes on yolk sac-derived endothelial-macrophage progenitors in postnatal murine tissues Doctor of Philosophy Doctorate Full Time Ms Sanuri Rashmitha Liyanage 2018 - 2022 Co-Supervisor Discovery and characterisation of yolk-sac derived Endothelial-Macrophage progenitor cells in postnatal murine tissues Doctor of Philosophy Doctorate Full Time Miss Anna Emilie Williamson 2018 - 2022 Principal Supervisor The Anti-Inflammatory and Pro-Angiogenic Capacity of High-Density Lipoproteins in Diabetic Wound Healing Doctor of Philosophy Doctorate Full Time Ms Zahra Lotfollahi 2018 - 2023 Principal Supervisor Investigating the theranostic properties of apoA-I-linked porphyrin-lipid nanoparticles in atherosclerosis Doctor of Philosophy Doctorate Full Time Miss Victoria Ann Nankivell 2018 - 2023 Principal Supervisor The role of Asialoglycoprotein Receptor-1 in Atherosclerosis Doctor of Philosophy Doctorate Full Time Mr Benjamin James Pullen 2017 - 2021 Co-Supervisor Vascular Calcification as a Risk Factor for Peripheral Arterial Disease and its Effects on Angiogenesis Doctor of Philosophy Doctorate Full Time Ms Jocelyne Mulangala
-
Committee Memberships
Date Role Committee Institution Country 2018 - ongoing President Australian Atherosclerosis Society N/A Australia -
Editorial Boards
Date Role Editorial Board Name Institution Country 2014 - ongoing Associate Editor Journal of Biochemistry - - 2013 - ongoing Associate Editor PLoS ONE - -
Connect With Me
External Profiles