Dr Christina Bursill
Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Department of Health and Medical Science. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.
Christina Bursill started as leader of the Plaque biology and New blood vessel area in January 2017 at the South Australian Health and Medical Research Institute and as a Senior Research Fellow at The University of Adelaide, Department of Health and Medical Science. She recently received the inaugural Lin Huddleston National Heart Foundation fellowship. Dr Bursill is a vascular biologist with interests and expertise in vascular inflammation, atherosclerosis and angiogenesis. She completed her PhD at The University of Adelaide in lipid metabolism then headed to Oxford University for five years to undergo a postdoctoral post in the Departments of Cardiovascular Medicine and Pathology. Her postdoctoral time triggered her interest in the mechanisms that cause atherosclerosis and in particular the role of small inflammatory proteins called Chemokines. Christina returned to Australia in 2007 at the Heart Research Institute (HRI) in Sydney where she led the Immunobiology Group. In 2008, Dr Bursill was awarded a National Heart Foundation Career Development Fellowship. At the HRI Dr Bursill developed an interest in high-density lipoproteins (HDL) and through NHMRC/NHF funding investigates novel mechanisms of their action in models of stent biocompatibility, diabetes and wound healing. She also has an interest in using viral gene transfer techniques to over-express proteins that attenuate chemokine activity to suppress atherosclerosis and inflammatory-driven diseases. In 2015 she was awarded the University of Sydney Thompson Fellowship.
Appointments
| Date | Position | Institution name |
|---|---|---|
| 2017 | Senior Research Fellow | The University of Adelaide |
Language Competencies
| Language | Competency |
|---|---|
| English | Can read, write, speak, understand spoken and peer review |
Education
| Date | Institution name | Country | Title |
|---|---|---|---|
| The University of Adelaide | Australia | BSc | |
| University of Adelaide, Adelaide | Australia | PhD | |
| The University of Adelaide | Australia | Hons 1 |
Postgraduate Training
| Date | Title | Institution | Country |
|---|---|---|---|
| 2017 | Leader Plaque Biology and New Blood Vessel Area | South Australian Health and Medical Research Institute, Adelaide | Australia |
| 2010 - 2016 | Leader Immunobiology Group | The Heart Research Institute, Newtown | Australia |
| 2007 - 2010 | Senior Research Officer | The Heart Research Institute, Newtown | Australia |
| 2001 - 2006 | Postdoctoral Fellow | University of Oxford, Oxford | United Kingdom |
Research Interests
Journals
| Year | Citation |
|---|---|
| 2017 | Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L. ... Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. FASEB Journal, 31, 3, 1179-1192. 10.1096/fj.201600540R |
| 2017 | Chen, X., Duong, M. -. N., Psaltis, P. J., Bursill, C. A. & Nicholls, S. J. (2017). High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes.. Cardiovascular diabetology, 16, 1, 121-. 10.1186/s12933-017-0605-8 |
| 2017 | Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M. ... Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. D. Jourd'heuil (Ed.). PLoS ONE, 12, 3, e0174773-1-e0174773-15. 10.1371/journal.pone.0174773 |
| 2017 | Ravindran, D., Ridiandries, A., Vanags, L., Henriquez, R., Cartland, S., Tan, J. & Bursill, C. (2017). Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. A. Boissonnas (Ed.). PLoS ONE, 12, 3, -. 10.1371/journal.pone.0173224 |
| 2017 | Tan, J. T., Prosser, H. C., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T. ... Bursill, C. A. (2017). High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I (vol 65, pg 3091, 2016). DIABETES, 66, 4, -. 10.2337/db17-er04b |
| 2017 | Vanags, L., Tan, J., Santos, M., Michael, P., Ali, Z., Bilek, M. ... Bursill, C. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 7, 2141-2150. 10.1016/j.nano.2017.06.012 |
| 2017 | van der Vorst, E., Theodorou, K., Wu, Y., Hoeksema, M., Goossens, P., Bursill, C. ... Biessen, E. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. Cell Metabolism, 25, 1, 197-207. 10.1016/j.cmet.2016.10.013 |
| 2016 | Lam, Y., Lecce, L., Tan, J., Bursill, C., Handelsman, D. & Ng, M. (2016). Androgen receptor-mediated genomic androgen action augments ischemia-induced neovascularization. Endocrinology, 157, 12, 4853-4864. 10.1210/en.2016-1301 |
| 2016 | Ridiandries, A., Tan, J. & Bursill, C. (2016). The role of CC-chemokines in the regulation of angiogenesis. International Journal of Molecular Sciences, 17, 11, 1856-1-1856-16. 10.3390/ijms17111856 |
| 2016 | Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L., Lam, Y., Tan, J. ... Bursill, C. (2016). Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids in Health and Disease, 15, 1, 150-1-150-12. 10.1186/s12944-016-0322-4 |
| 2016 | Tan, J., Prosser, H., Dunn, L., Vanags, L., Ridiandries, A., Tsatralis, T. ... Bursill, C. (2016). High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor Class B Type I. Diabetes, 65, 10, 3091-3103. 10.2337/db15-1668 |
| 2015 | Chalmers, A., Cohen, A., Bursill, C. & Myerscough, M. (2015). Bifurcation and dynamics in a mathematical model of early atherosclerosis: how acute inflammation drives lesion development. Journal of Mathematical Biology, 71, 6, 1451-1480. 10.1007/s00285-015-0864-5 |
| 2015 | Kim, C., Mitchell, J., Bursill, C., Sowers, A., Thetford, A., Cook, J. ... Davies, M. (2015). The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE¯⁄¯mice. Atherosclerosis, 240, 1, 234-241. 10.1016/j.atherosclerosis.2015.03.012 |
| 2015 | Tan, J., Ng, M. & Bursill, C. (2015). The role of high-density lipoproteins in the regulation of angiogenesis. Cardiovascular Research, 106, 2, 184-193. 10.1093/cvr/cvv104 |
| 2014 | Prosser, H., Tan, J., Dunn, L., Patel, S., Vanags, L., Bao, S. ... Bursill, C. (2014). Multifunctional regulation of angiogenesis by high-density lipoproteins. Cardiovascular Research, 101, 1, 145-154. 10.1093/cvr/cvt234 |
| 2014 | Brown, B., Kim, C., Torpy, F., Bursill, C., McRobb, L., Heather, A. ... Van Reyk, D. (2014). Supplementation with carnosine decreases plasma triglycerides andmodulates atherosclerotic plaque composition in diabetic apoE-/- mice. Atherosclerosis, 232, 2, 403-409. 10.1016/j.atherosclerosis.2013.11.068 |
| 2014 | Tan, J., Hamish, H., Vanags, L., Monger, S., Ng, M. & Bursill, C. (2014). High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1α. FASEB Journal, 28, 1, 206-217. 10.1096/fj.13-233874 |
| 2014 | Dunn, L., Simpson, P., Prosser, H., Lecce, L., Yuen, G., Buckle, A. ... Ng, M. (2014). A critical role for Thioredoxin- Interacting protein in diabetes-related impairment of angiogenesis. Diabetes, 63, 2, 675-687. 10.2337/db13-0417 |
| 2013 | Van Der Vorst, E., Vanags, L., Dunn, L., Prosser, H., Rye, K. & Bursill, C. (2013). High-density lipoproteins suppress chemokine expression and proliferation in human vascular smooth muscle cells. FASEB Journal, 27, 4, 1413-1425. 10.1096/fj.12-212753 |
| 2013 | Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M. & Bursill, C. (2013). Murine model of wound healing. Journal of Visualized Experiments, 2013, 75, e50265-1-e50265-6. 10.3791/50265 |
| 2013 | Dunn, L., Prosser, H., Tan, J., Vanags, L., Ng, M. & Bursill, C. (2013). Murine model of wound healing.. Journal of visualized experiments : JoVE, 75, -. |
| 2012 | Prosser, H., Ng, M. & Bursill, C. (2012). The role of cholesterol efflux in mechanisms of endothelial protection by HDL. Current Opinion in Lipidology, 23, 3, 182-189. 10.1097/MOL.0b013e328352c4dd |
| 2011 | Di Bartolo, B., Vanags, L., Tan, J., Bao, S., Rye, K., Barter, P. & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit.. Lipids in health and disease, 10, 1, 224-224. 10.1186/1476-511X-10-224 |
| 2010 | Bursill, C., Castro, M., Beattie, D., Nakhla, S., Van Der Vorst, E., Heather, A. ... Rye, K. (2010). High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30, 9, 1773-1778. 10.1161/ATVBAHA.110.211342 |
| 2009 | Rye, K., Bursill, C., Lambert, G., Tabet, F. & Barter, P. (2009). The metabolism and anti-atherogenic properties of HDL. Journal of Lipid Research, 50, SUPPL., S195-S200. 10.1194/jlr.R800034-JLR200 |
| 2009 | Stevenson, N., Addley, M., Ryan, E., Boyd, C., Carroll, H., Paunovic, V. ... Johnston, J. (2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. Journal of Leukocyte Biology, 85, 2, 289-297. 10.1189/jlb.0708394 |
| 2009 | Seki, E., De Minicis, S., Gwak, G., Kluwe, J., Inokuchi, S., Bursill, C. ... Schwabe, R. (2009). CCR1 and CCR5 promote hepatic fibrosis in mice. Journal of Clinical Investigation, 119, 7, 1858-1870. 10.1172/JCI37444 |
| 2009 | Bursill, C., McNeill, E., Wang, L., Hibbitt, O., Wade-Martins, R., Paterson, D. ... Channon, K. (2009). Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition. Gene Therapy, 16, 1, 93-102. 10.1038/gt.2008.141 |
| 2008 | McAteer, M., Schneider, J., Ali, Z., Warrick, N., Bursill, C., Von Zur Muhlen, C. ... Choudhury, R. (2008). Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1, 77-83. 10.1161/ATVBAHA.107.145466 |
Conference Papers
| Year | Citation |
|---|---|
| 2008 | Ali, Z., Bursill, C., Douglas, G., McNeill, E., Papaspyridonos, M., Tatham, A. ... Channon, K. (2008). CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.. 80th Annual Scientific Session of the American-Heart-Association. Orlando, FL. 10.1161/CIRCULATIONAHA.107.753558 |
Conference Items
| Year | Citation |
|---|---|
| 2016 | Tan, J., Hourigan, S., Zhang, J., Wong, N., Tepper, E., Prosser, H. ... Bursill, C. (2016). miRNA-181c and its putative target TRIM2 mediate the ability of high density lipoproteins to rescue diabetes-impaired angiogenesis. 76th Scientific Sessions of the American Diabetes Association. New Orleans, LA. |
| 2015 | Tan, J. T., Prosser, H. C., Dunn, L. L., Vanags, L. Z., Ridiandries, A., Tsatralis, T. ... Bursill, C. A. (2015). High Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor-BI and Restoration of VEGF and HIF-1 alpha Stability. 75th Scientific Sessions of the American-Diabetes-Association. Boston, MA. |
| 2014 | Van der Vorst, E., Theodorou, K., Plat, J., Van Eck, M., Rye, K., Bursill, C. ... Donners, M. (2014). High density lipoproteins exert pro-inflammatory effects on macrophages via IKK2-and NIK-independent NF-kB activation. 3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology. Barcelona, SPAIN. 10.1093/cvr/cvu075.2 |
| 2013 | Morton, J., Bao, S., Celermajer, D. S., Ng, M. K. & Bursill, C. A. (2013). Strikingly Different Atheroprotective Effects of Apolipoprotein A-I in Early-Stage Versus Late-Stage Atherosclerosis. Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX. |
| 2013 | Prosser, H. C., Tan, J. T., Dunn, L. L., Patel, S., Vanags, L. Z., Monger, S. ... Bursill, C. A. (2013). Multifunctional Regulation of Angiogenesis by High Density Lipoproteins. Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association. Dallas, TX. |
| 2012 | Quigley, A. F., Summers, F., Barrett, T., Bursill, C. & Hawkins, C. (2012). A novel role of myeloperoxidase in the induction of endoplasmic reticulum (ER) stress. 10.1016/j.freeradbiomed.2012.08.561 |
| 2012 | Quigley, A. F., Summers, F. A., Barrett, T. J., Bursill, C. A. & Hawkins, C. L. (2012). A Novel Role for Myeloperoxidase in the Induction of C/EBP-Homologous Protein (CHOP). 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM). San Diego, CA. 10.1016/j.freeradbiomed.2012.10.438 |
·National Heart Foundation Lin Huddleston Foundation Fellowship (2017-2022)
Chief Investigator: Christina Bursill (CIA)
Amount: ~$750,000 over 5 years
·Diabetes Australia Research (DART) grant (2017)
Title: ‘Micromanaging’ high-density lipoprotein-induced rescue of diabetes-impaired angiogenesis
Chief Investigators: Joanne Tan and Christina Bursill
Amount: $60,000
· NAB Career Re-start Grant (2016)
Title: Reversing the progression of atherosclerosis
Chief Investigators: Christina Bursill (CIA),
Amount: $60,000 over one year
· ARC Discovery Grant (2016)
Title: Dynamics of atherosclerotic plaque formation, growth and regression
Chief Investigators: Mary Myerscough (CIA), Charlie Macaskill (CIB), Christina Bursill (PI).
Amount: $218,768 over three years
· University of Sydney - Thompson Fellowship (2016)
Title: Using the "Good Cholesterol" to increase stent longevity
Chief Investigator: Christina Bursill (CIA)
Amount: $90, 000 over one year
· University of Sydney Bridging Grant (2015)
Title: Different athero-protective properties of HDL in early versus late atherosclerosis
Chief Investigators: Christina Bursill (CIA)
Amount: $30, 000 over 1 year
· NHMRC Project Grant (2015)
Title: Oxidative Regulation of the Na pump – a new player in vascular function in health and disease.
Chief Investigators: Gemma Figtree (CIA), Christina Bursill (CIB), A/Prof Ravinay Bhindi (CIC), Prof Keith Channon (CID), A/Prof Clare Hawkins (CIE), Dr Ben Davies (CIF), Prof Richard Cohen (CIG).
Amount: $488,816 over three years
· University of Sydney Bridging Grant (2013)
Title: Differential Regulation of Angiogenesis by CC-Chemokines
Chief Investigators: Christina Bursill (CIA)
Amount: $30, 000 over 1 year
· NHMRC project grant (2010-2013)
Title: Multifunctional regulation of Angiogenesis by High Density Lipoproteins
Chief Investigators: Martin Ng (CIA), Christina Bursill (CIB)
Amount: $476, 000 over 3 years
· Heart Foundation Career Development Fellowship (2008-2013)
Title: The Role of Chemokines in the Anti-Atherosclerotic Effects of HDL
Chief Investigator: Christina Bursill
Amount: $515,000 – includes 5 years salary, travel funds and equipment support.
·Bushell Foundation (2008-2011)
Title: Understanding the Anti-Atherosclerotic Properties of High Density Lipoproteins
Investigator: Christina Bursill
Amount: $250, 000 over 3 years
· British Heart Foundation Program Grant (2005-2007):
Title: Evaluation of Broad Spectrum Chemokine agonists to Inhibit Atherosclerosis
Investigators: Keith Channon, David Greaves, and Christina Bursill
Amount: £715,961 over 5 years
· British Heart Foundation Project Grant (2001-2004):
Title: Evaluation of Broad Spectrum CC-Chemokine antagonists to Inhibit Inflammatory Cell Recruitment in Atherogenesis.
Investigators: David Greaves, Keith Channon, and Christina Bursill
Amount: £152,326 over 3 years. Based on the success of the project, the initial grant was extended for a further 2.5 years (£126,939) based on my research.
Undergraduate Teaching:
·1997-98: Tutor for 1st year Medical students in Problem Based Learning, Department of Medicine, University of Adelaide.
·1998-2000: Demonstrator for 2nd year Science students in Cardiovascular Physiology, Department of Physiology, University of Adelaide.
·2001: Lecturer to 2nd year Medical students on Lipoprotein Metabolism, Department of Pathology, University of Oxford, UK.
·2001, 2002: Demonstrator for 2nd year Medical Students in Atherosclerosis and Thrombosis, Department of Pathology, University of Oxford, UK.
·2004-2006: Lecturer to 3rd year Medical students in ‘Methods and Approach in Scientific Research’. Department of Medicine, University of Oxford, UK.
·2015-2026: Lecturer to 3rd year Physiology students on “Vascular Inflammation”, University of Sydney, NSW.
Completed PhD Students as Primary Supervisor:
1. Name: Ziad Ali, MB ChB (Hons) DPhil MRCS MRCP
Candidature: August 2003-October 2006
Current position: NIH Career Development Fellow, Columbia University, NY, USA.
2. Name: Belinda DiBartolo, (Hons 1) BMedSc
Candidature: May 2006-May 2009
Current Position: Senior Postdoctoral Fellow, NHMRC Early-Career Fellow, SAHMRI.
3. Name: Dr Jamie Morton
Candidature: Feb 2010-Apr 2013
Current Position: Clinical Cardiologist, Royal Adelaide Hospital
Awards: Offered both the NHMRC and the Heart Foundation PhD scholarships. Received a Young Investigator Award from the Cardiac Society of Australia and New Zealand, Brisbane, 2012.
4. Name: Laura Vanags BSc (Hons1) PhD
Candidature: July 2012 – May 2016
Current Position: Maternity leave
Awards: NHF PhD Scholarship, AAS winner of 2 x Young Investigator Award (Oral, 2013 & 2015). Received NHF Exchange and Collaboration Award ($5000).
5. Name: Anisyah Ridiandries BSc (Hons 1) PhD
Candidature: March 2012 – Dec 2015
Current Position: Postdoctoral researcher, Kolling Institute, Sydney (Jan 2017)
Awards: James King of Irrawang Travelling Scholarship (USyd) to attend ATVB 2015, San Francisco, CA, USA ($1500) and visit laboratories around the USA.
Editorial Boards
| Date | Role | Editorial Board Name | Country |
|---|---|---|---|
| 2014 - ongoing | Associate Editor | Journal of Biochemistry | |
| 2013 - ongoing | Associate Editor | PLoS ONE |