Christian Huber

Dr Christian Huber

ARC DECRA Fellow

School of Biological Sciences

Faculty of Sciences

I am a computational biologist with a track record of combing theoretical and empirical analyses to quantify and understand natural selection in the genome. I studied with Ines Hellmann, Joachim Hermisson, and Magnus Nordborg at the University of Vienna, Austria while pursuing my PhD, and did three years of postdoctoral research with Kirk E. Lohmueller at the University of California, Los Angeles. Recently, I was awarded the prestigious Discovery Early Career Research Award for the project “Palaeo-population genomics: studying adaptation using ancient human DNA” that I started as a Principal Investigator at the University of Adelaide in Australia.

During my graduate work, I used population genetic methods to investigate local adaptation within subpopulations of Swedish A. thaliana. Further, I developed a powerful new method for detecting signatures of positive selection in the genome to identified novel candidate regions in humans. During my postdoctoral position, I worked on characterizing and interpreting fitness effects of deleterious mutations in different species, developing a novel comparative population-genomic framework. I am currently working on new approaches for detecting and interpreting adaption in recent human history using ancient DNA, integrating selection scans with prior biological knowledge of molecular pathways and networks.

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  • Journals
    Year Citation
    2021 Zhen, Y., Huber, C. D., Davies, R. W., & Lohmueller, K. E. (2021). Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster. Genome Research, 31(1), 110-120.
    DOI
    2021 Teixeira, J. C., & Huber, C. D. (2021). The inflated significance of neutral genetic diversity in conservation genetics.. Proceedings of the National Academy of Sciences of the United States of America, 118(10), e2015096118.
    DOI
    2020 Popitsch, N., Huber, C. D., Buchumenski, I., Eisenberg, E., Jantsch, M., von Haeseler, A., & Gallach, M. (2020). A-to-I RNA Editing Uncovers Hidden Signals of Adaptive Genome Evolution in Animals. Genome biology and evolution, 12(4), 345-357.
    DOI Scopus2 Europe PMC1
    2020 Huber, C. D., Kim, B. Y., & Lohmueller, K. E. (2020). Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution.. PLoS genetics, 16(5), e1008827.
    DOI Scopus1
    2018 Huber, C. D., Durvasula, A., Hancock, A. M., & Lohmueller, K. E. (2018). Gene expression drives the evolution of dominance. Nature Communications, 9(1), 1-11.
    DOI
    2018 Kim, B. Y., Huber, C. D., & Lohmueller, K. E. (2018). Deleterious variation shapes the genomic landscape of introgression. PLoS Genetics, 14(10), e1007741-1-e1007741-30.
    DOI Scopus22 Europe PMC13
    2017 Popitsch, N., Huber, C. D., Buchumenski, I., Eisenberg, E., Jantsch, M., von Haeseler, A., & Gallach, M. (2017). A-to-I RNA editing uncovers hidden signals of adaptive genome evolution in animals. bioRxiv, 228734.
    DOI
    2017 Kim, B. Y., Huber, C. D., & Lohmueller, K. (2017). Deleterious variation mimics signatures of genomic incompatibility and adaptive introgression. bioRxiv, 221705.
    DOI
    2017 Huber, C. D., Kim, B. Y., Marsden, C. D., & Lohmueller, K. E. (2017). Determining the factors driving selective effects of new nonsynonymous mutations. Proceedings of the National Academy of Sciences, 114(17), 4465-4470.
    DOI
    2017 Kim, B. Y., Huber, C. D., & Lohmueller, K. E. (2017). Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples. Genetics, 206(1), 345-361.
    DOI
    2016 Phung, T. N., Huber, C. D., & Lohmueller, K. E. (2016). Determining the effect of natural selection on linked neutral divergence across species. PLoS genetics, 12(8), 1-27.
    DOI Scopus17 Europe PMC16
    2016 DeGiorgio, M., Huber, C. D., Hubisz, M. J., Hellmann, I., & Nielsen, R. (2016). SweepFinder2: increased sensitivity, robustness and flexibility. Bioinformatics, 32, 1895-1897.
    2016 DeGiorgio, M., Huber, C. D., Hubisz, M. J., Hellmann, I., & Nielsen, R. (2016). User Manual for SweepFinder2.
    2016 Reich, K. M., Huber, C. D., Heimel, P., Ulm, C., Redl, H., & Tangl, S. (2016). A quantification of regenerated bone tissue in human sinus biopsies: influences of anatomical region, age and sex. Clinical Oral Implants Research, 27(5), 583-590.
    DOI
    2016 Huber, C. D., DeGiorgio, M., Hellmann, I., & Nielsen, R. (2016). Detecting recent selective sweeps while controlling for mutation rate and background selection. Molecular Ecology, 25(1), 142-156.
    DOI
    2015 Vasak, C., Strbac, G. D., Huber, C. D., Lettner, S., Gahleitner, A., & Zechner, W. (2015). Evaluation of Three Different Validation Procedures regarding the Accuracy of Template-Guided Implant Placement: An In Vitro Study. Clinical implant dentistry and related research, 17(1), 142-149.
    DOI
    2015 Phung, T., Huber, C., & Lohmueller, K. (2015). Natural selection reduces linked neutral divergence between distantly related species. bioRxiv, 031740.
    DOI
    2014 Huber, C. D., Nordborg, M., Hermisson, J., & Hellmann, I. (2014). Keeping it local: evidence for positive selection in Swedish Arabidopsis thaliana. Molecular Biology and Evolution, 31(11), 3026-3039.
    DOI
    2014 Klepsatel, P., Gáliková, M., Huber, C. D., & Flatt, T. (2014). Similarities and differences in altitudinal versus latitudinal variation for morphological traits in Drosophila melanogaster. Evolution, 68(5), 1385-1398.
    DOI
    2013 Long, Q., Rabanal, F. A., Meng, D., Huber, C. D., Farlow, A., Platzer, A., . . . others. (2013). Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden. Nature genetics, 45, 884.
    2013 Klepsatel, P., Gáliková, M., De Maio, N., Huber, C. D., Schlötterer, C., & Flatt, T. (2013). Variation in thermal performance and reaction norms among populations of Drosophila melanogaster. Evolution, 67, 3573-3587.
    2013 Arnhart, C., Dvorak, G., Trefil, C., Huber, C., Watzek, G., & Zechner, W. (2013). Impact of implant surface topography: a clinical study with a mean functional loading time of 85 months. Clinical oral implants research, 24, 1049-1054.
    2013 Vasak, C., Strbac, G. D., Huber, C. D., Lettner, S., Vorauer, M., Gahleitner, A., & Zechner, W. (2013). evaluation of three different validation procedures regarding the accuracy of templateguided implant placement: an: 362in vitro: 362study: 362. Clinical Oral Implants Research, 24, 177.
    2012 Wiehart, C., Wallner, B., Rohrer, M., Huber, C., Plenk Jr, H., & Koenig, H. E. (2012). Microhardness measurements of teeth from German Shepherd dogs as an alternative method for age estimation. WIENER TIERARZTLICHE MONATSSCHRIFT, 99, 91-100.
    2012 Wiehart, C., Wallner, B., Rohrer, M., Huber, C., Plenk Jr, H., & König, H. E. (2012). Mikrohärtemessungen als alternative Methode zur Altersschätzung an den Zähnen von Deutschen Schäferhunden. Wiener Tierarztliche Monatsschrift, 99, 91.
    2012 Zhang, Y., Tangl, S., Huber, C. D., Lin, Y., Qiu, L., & Rausch-Fan, X. (2012). Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. Journal of Cranio-Maxillofacial Surgery, 40, 321-328.
    2011 Reich, K. M., Huber, C. D., Lippnig, W. R., Ulm, C., Watzek, G., & Tangl, S. (2011). Atrophy of the residual alveolar ridge following tooth loss in an historical population. Oral Diseases, 17, 33-44.
    2011 Dvorak, G., Arnhart, C., Heuberer, S., Huber, C. D., Watzek, G., & Gruber, R. (2011). Peri-implantitis and late implant failures in postmenopausal women: a cross-sectional study. Journal of clinical periodontology, 38, 950-955.
    2010 Hoke, M., Koppensteiner, R., Schillinger, M., Haumer, M., Minar, E., Wiesbauer, F., . . . Mlekusch, W. (2010). D-dimer testing in the diagnosis of transfemoral pseudoaneurysm after percutaneous transluminal procedures. Journal of vascular surgery, 52, 383-387.
    2010 Meinl, A., Rottensteiner, G. M., Huber, C. D., Tangl, S., Watzak, G., & Watzek, G. (2010). Caries frequency and distribution in an early medieval Avar population from Austria. Oral diseases, 16, 108-116.
    2010 Dvorak, G., Heuberer, S., Arnhart, C., Huber, C., Watzek, G., & Gruber, R. (2010). Osteoporosis and clinical features of peri-implantitis: 102. Clinical Oral Implants Research, 21, 1031.
    2009 Arnhart, C., Pommer, B., Unger, E., Cepic, L., Huber, C., Watzak, G., & Watzek, G. (2009). Heat progression in human bone caused by trephine osteotomies: influence of irrigation mode concerning drilling depth, drill diameter and drill wear out: 392 Poster-Topic Material Research. Clinical Oral Implants Research, 20, 1032-1033.
    2009 Busenlechner, D., Huber, C. D., Vasak, C., Dobsak, A., Gruber, R., & Watzek, G. (2009). Sinus augmentation analysis revised: the gradient of graft consolidation. Clinical Oral Implants Research, 20, 1078-1083.
    2008 Dvorak, G., Gruber, R., Huber, C. D., Goldhahn, J., Zanoni, G., Salaberger, D., . . . Haas, R. (2008). Trabecular bone structures in the edentulous diastema of osteoporotic sheep. Journal of dental research, 87, 866-870.
    2008 Meinl, A., Huber, C. D., Tangl, S., Gruber, G. M., Teschler-Nicola, M., & Watzek, G. (2008). Comparison of the validity of three dental methods for the estimation of age at death. Forensic science international, 178, 96-105.
    2007 Meinl, A., Tangl, S., Huber, C., Maurer, B., & Watzek, G. (2007). The chronology of third molar mineralization in the Austrian population—a contribution to forensic age estimation. Forensic science international, 169, 161-167.
    — Tobler, R., Johar, A., Huber, C., & Souilmi, Y. (n.d.). PolyLinkR: A linkage-sensitive gene set enrichment R package.
    — Teixeira, J. C., & Huber, C. D. (n.d.). Dismantling a dogma: the inflated significance of neutral genetic
    diversity in conservation genetics.

  • Book Chapters
    Year Citation
    2016 Huber, C. D., & Lohmueller, K. E. (2016). Neutral Evolution, Population Genetic Tests of. In R. M. Kilman (Ed.), Encyclopedia of Evolutionary Biology (Vol. 3, pp. 112-118). Academic Press.

  • Conference Papers
    Year Citation
    2010 Dvorak, G., Movsissian, I., Arnhart, C., Huber, C., Watzek, G., & Gruber, R. (2010). OSTEOPOROSIS AND CLINICAL FEATURES OF ORAL PERI-IMPLANTITIS. In OSTEOPOROSIS INTERNATIONAL Vol. 21 (pp. 89). SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND.
    2007 Huber, C. D., Bookstein, F. L., & Weber, G. W. (2007). Tooth shape and enamel thickness variation in primate teeth: An approach using topographic thickness maps.. In American Journal of Physical Anthropology (pp. 132). WILEY-LISS DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA.

  • Theses
    Year Citation
    2014 Huber, C. D. (2014). Detecting selective sweeps on top of complex demographies and background selection. (PhD Thesis).
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  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2020 Co-Supervisor THE INFLUENCE OF CONTEXT EFFECT ON DECISION MAKING IN FORENSIC ODONTOLOGY IDENTIFICATION Doctor of Philosophy Doctorate Part Time Dr Sher-Lin Chiam
    2020 Co-Supervisor Investigating the effects of fluctuating selection on patterns of genetic variation Doctor of Philosophy Doctorate Full Time Miss Olivia Lenore Johnson
    2019 Co-Supervisor Using Machine Learning Methods to Detect Selective Sweeps in Ancient DNA Master of Philosophy Master Full Time Mr Shing Yan Kwong
  • Position: ARC DECRA Fellow
  • Phone: 83138242
  • Email: christian.huber@adelaide.edu.au
  • Fax: 8313 4364
  • Campus: North Terrace
  • Building: Darling, floor 2
  • Room: 2 05b
  • Org Unit: Ecology and Evolutionary Biology
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