Chris Proud

Professor Chris Proud

School of Biological Sciences

Faculty of Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Professor Chris Proud held numerous positions as lecturer, reader or professor in universities in the UK, Germany and Canada before moving to Adelaide, in September 2014, to take up the position of inaugural Theme Leader: Nutrition and Metabolism at SAHMRI. In January 2016 Chris succeeded Professor John Hopwood as Director of the Lysosomal Diseases Research Unit.

Chris continues his long-standing interest in the molecular mechanisms by which nutrients and hormones regulate mammalian cell function, especially protein metabolism and gene expression and the roles they play in health and disease.

Chris is also holds a Distinguished Foreign Expert position at Zhejiang University in China.

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  • Appointments

    Date Position Institution name
    2016 Distinguish Foreign Expert Zhejiang University, Hangzhou
    2014 Theme Leader, Nutrition & Metabolism South Australian Health & Medical Research Institute (SAHMRI)
    2014 Professor in Molecular and Biomedical Science University of Adelaide, Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2012 Invitation Plenary Speaker, 2012 International Symposium on Organic Synthesis and Drug Discovery China
    2012 Invitation Plenary Speaker, Presidential Symposium, American Society for Nutrition United States
    2010 Invitation Invited Presenter, Henry Stewart ‘Online Seminars by Leading World Experts’; topic: “Protein Phosphorylation and the Control of Protein Synthesis”
    2010 Invitation Plenary Speaker, 2010 International Symposium on Organic Synthesis and Drug Discovery China
    2009 Honour Honorary Professor Qingdao Ocean University China
    2009 Honour Jinji Lake Double-hundred Talents Program China
    2008 Invitation Expert Speaker, Meeting of American Association for Cancer Research United States
    2008 Award Wolfson Research Merit Award Royal Society United Kingdom
    2008 Honour ‘Faculty of 1000’
    2004 Invitation Susan Swerling Lecturer Dana-Farber Cancer Institute United States
    2004 Invitation Keynote Speaker Heart Failure Society of America Canada
    2003 Invitation Plenary Speaker, Annual Meeting, South African Society of Biochemistry & Molecular Biology
    2001 Fellowship Elected Fellow Institute of Biology (now the Royal Society for Biology) & Chartered Biologist
  • Language Competencies

    Language Competency
    Chinese (Mandarin) Can read, write, speak and understand spoken
    German Can read, write, speak and understand spoken
  • Education

    Date Institution name Country Title
    1974 - 1977 University of Dundee, Dundee United Kingdom Ph. D. Biochemistry
    1971 - 1974 University of Bristol, Bristol United Kingdom Honours B. Sc. Biochemistry
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  • Journals

    Year Citation
    2019 Proud, C. (2019). Phosphorylation and signal transduction pathways in translational control. Cold Spring Harbor Perspectives in Biology, 11(7), a033050-1-a033050-22.
    DOI Scopus14 WoS17 Europe PMC7
    2019 Jin, X., Merrett, J., Tong, S., Flower, B., Xie, J., Yu, R., . . . Proud, C. (2019). Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold. European Journal of Medicinal Chemistry, 162, 735-751.
    DOI Scopus2
    2019 Xie, J., Merrett, J., Jensen, K., & Proud, C. (2019). The MAP kinase-interacting kinases (MNKs) as targets in oncology. Expert Opinion on Therapeutic Targets, 23(3), 187-199.
    DOI Scopus3 WoS3 Europe PMC1
    2019 Lie, S., Wang, T., Forbes, B., Proud, C., & Petersen, J. (2019). The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1. Scientific Reports, 9(1), 15 pages.
    DOI
    2019 Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R., Jensen, K., . . . Proud, C. (2019). Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan. Current Biology, 29(5), 737-749.e5.
    DOI Scopus1 WoS2 Europe PMC1
    2019 Xie, J., Van Damme, P., Fang, D., & Proud, C. (2019). Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress. Journal of Biological Chemistry, 294(18), 7169-7176.
    DOI
    2019 Charitou, T., Srihari, S., Lynn, M., Jarboui, M., Fasterius, E., Moldovan, M., . . . Lynn, D. (2019). Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRAS<sup>G13D</sup> mutation. British Journal of Cancer, 121(1), 37-50.
    DOI Scopus1
    2019 Lages, A., Proud, C., Holloway, J., & Vorechovsky, I. (2019). Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1. Molecular Therapy - Nucleic Acids, 16, 770-777.
    DOI
    2019 Zhou, Y., Li, Y., Xu, S., Lu, J., Zhu, Z., Chen, S., . . . Shen, K. (2019). Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3. International Journal of Cancer, 13 pages.
    DOI
    2018 Fedele, A., Isenmann, S., Kamei, M., Snel, M., Trim, P., Proud, C., & Hopwood, J. (2018). Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(10), 1451-1464.
    DOI Scopus2 WoS1
    2018 Li, Y., Song, Y., Zhao, M., Guo, Y., Yu, C., Chen, W., . . . Gao, L. (2018). A Novel Role for CRTC2 in Hepatic Cholesterol Synthesis Through SREBP-2 (vol 66, pg 481, 2017). HEPATOLOGY, 67(3), 1188.
    DOI
    2018 Wisse, L., Ter Braak, T., Van De Beek, M., Van Berkel, C., Wortel, J., Heine, V., . . . Abbink, T. (2018). Adult mouse eIF2Bϵ Arg191His astrocytes display a normal integrated stress response in vitro. Scientific Reports, 8(1), 3773.
    DOI Scopus2 WoS2 Europe PMC2
    2018 Liu, L., Li, Q., Yuan, Z., Zhao, M., Zhang, X., Zhang, H., . . . Hou, X. (2018). Non-high-density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance.. Journal of diabetes investigation, 9(6), 1304-1311.
    DOI Scopus1 WoS1 Europe PMC1
    2018 Xie, J., Wang, X., & Proud, C. (2018). Who does TORC2 talk to. Biochemical Journal, 475(10), 1721-1738.
    DOI Scopus2 WoS2 Europe PMC1
    2018 Tangseefa, P., Martin, S., Fitter, S., Baldock, P., Proud, C., & Zannettino, A. (2018). Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance. Journal of Cellular Physiology, 233(5), 3769-3783.
    DOI Scopus3 WoS4 Europe PMC1
    2018 Xie, J., Shen, K., Lenchine, R., Gethings, L., Trim, P., Snel, M., . . . Proud, C. (2018). Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis. International Journal of Cancer, 142(9), 1865-1877.
    DOI Scopus5 WoS5 Europe PMC1
    2017 Wisse, L., Penning, R., Zaal, E., van Berkel, C., ter Braak, T., Polder, E., . . . Abbink, T. (2017). Proteomic and metabolomic analyses of vanishing white matter mouse astrocytes reveal deregulation of ER functions. Frontiers in Cellular Neuroscience, 11, 16 pages.
    DOI Scopus1 WoS2 Europe PMC1
    2017 Wang, X., Xie, J., & Proud, C. (2017). Eukaryotic elongation factor 2 kinase (eEF2K) in cancer. Cancers, 9(12), 162-1-162-15.
    DOI Scopus8 WoS6 Europe PMC2
    2017 Hein, L., Apaja, P., Hattersley, K., Grose, R., Xie, J., Proud, C., & Sargeant, T. (2017). A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Biochimica et Biophysica Acta - Molecular Cell Research, 1864(10), 1554-1565.
    DOI Scopus3 WoS3 Europe PMC2
    2017 Fitter, S., Matthews, M., Martin, S., Xie, J., Ooi, S., Walkley, C., . . . Zannettino, A. (2017). mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation. Molecular and Cellular Biology, 37(7), e00668-1-e00668-20.
    DOI Scopus19 WoS11 Europe PMC11
    2017 Li, Y., Song, Y., Zhao, M., Guo, Y., Yu, C., Chen, W., . . . Gao, L. (2017). A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2. Hepatology, 66(2), 481-497.
    DOI Scopus9 WoS11 Europe PMC3
    2017 Johanns, M., Pyr dit Ruys, S., Houddane, A., Vertommen, D., Herinckx, G., Hue, L., . . . Rider, M. (2017). Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cellular Signalling, 36, 212-221.
    DOI Scopus15 WoS16 Europe PMC9
    2017 Tian, S., Wang, X., & Proud, C. (2017). Oncogenic MNK signalling regulates the metastasis suppressor NDRG1. Oncotarget, 8(28), 46121-46135.
    DOI Scopus3 WoS3
    2017 Brace, P., Tezera, L., Bielecka, M., Mellows, T., Garay, D., Tian, S., . . . Elkington, P. (2017). Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology. PLoS Pathogens, 13(6), e1006367-1-e1006367-25.
    DOI Scopus13 WoS14 Europe PMC9
    2017 Heise, C., Taha, E., Murru, L., Ponzoni, L., Cattaneo, A., Guarnieri, F., . . . Sala, C. (2017). eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.. Cerebral cortex (New York, N.Y. : 1991), 27(3), 2226-2248.
    DOI Scopus18 WoS15 Europe PMC9
    2016 Moore, C., Pickford, J., Cagampang, F., Stead, R., Tian, S., Zhao, X., . . . Proud, C. (2016). MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways. Scientific Reports, 6(1), 23476-1-23476-15.
    DOI Scopus3 WoS2
    2016 Ham, D., Caldow, M., Chhen, V., Chee, A., Wang, X., Proud, C., . . . Koopman, R. (2016). Glycine restores the anabolic response to leucine in a mouse model of acute inflammation. American Journal of Physiology - Endocrinology and Metabolism, 310(11), E970-E981.
    DOI Scopus9 WoS8 Europe PMC5
    2016 Averous, J., Lambert-Langlais, S., Mesclon, F., Carraro, V., Parry, L., Jousse, C., . . . Fafournoux, P. (2016). GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Scientific Reports, 6(1), 27698-1-27698-10.
    DOI Scopus18 WoS18 Europe PMC13
    2016 Pan, W., Kremer, K., Kaidonis, X., Ludlow, V., Rogers, M., Xie, J., . . . Koblar, S. (2016). Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells. International Journal of Developmental Neuroscience, 53, 90-98.
    DOI Scopus5 WoS6 Europe PMC5
    2016 Bramham, C., Jensen, K., & Proud, C. (2016). Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis. Trends in Biochemical Sciences, 41(10), 847-858.
    DOI Scopus30 WoS26 Europe PMC20
    2016 Liua, R., Kenney, J., Manousopoulou, A., Johnston, H., Kamei, M., Woelk, C., . . . Proud, C. (2016). Quantitative non-canonical amino acid tagging (QuaNCAT) proteomics identifies distinct patterns of protein synthesis rapidly induced by hypertrophic agents in cardiomyocytes, revealing new aspects of metabolic remodeling. Molecular and Cellular Proteomics, 15(10), 3170-3189.
    DOI Scopus7 WoS6 Europe PMC3
    2016 Wang, X., & Proud, C. (2016). mTORC2 is a tyrosine kinase. Cell Research, 26(1), 1-2.
    DOI Scopus7 WoS7 Europe PMC10
    2016 Wortham, N., Stewart, J., Harris, S., Coldwell, M., & Proud, C. (2016). Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits. Biochemical Journal, 473(5), 571-580.
    DOI Scopus2 WoS2 Europe PMC1
    2016 Liu, R., & Proud, C. (2016). Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases. Acta Pharmacologica Sinica, 37(3), 285-294.
    DOI Scopus20 WoS18 Europe PMC12
    2016 Moore, C., Wang, X., Xie, J., Pickford, J., Barron, J., Regufe da Mota, S., . . . Proud, C. (2016). Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy. Cellular Signalling, 28(4), 284-293.
    DOI Scopus15 WoS13 Europe PMC8
    2016 Xie, J., Wang, X., & Proud, C. (2016). mTOR inhibitors in cancer therapy [version 1; referees: 3 approved]. F1000Research, 5, 2078.
    DOI Scopus43 Europe PMC35
    2016 Juli, G., Gismondi, A., Monteleone, V., Caldarola, S., Iadevaia, V., Aspesi, A., . . . Loreni, F. (2016). Depletion of ribosomal protein S19 causes a reduction of rRNA synthesis. Scientific Reports, 6(1), 35026-1-35026-10.
    DOI Scopus4 WoS4 Europe PMC3
    2016 Jossé, L., Xie, J., Proud, C., & Smales, C. (2016). MTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GSCHOK1 cells. Biochemical Journal, 473(24), 4651-4664.
    DOI Scopus14 WoS13 Europe PMC10
    2016 Xiao, T., Liu, R., Proud, C., & Wang, M. (2016). A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors. Acta Pharmaceutica Sinica B, 6(6), 557-563.
    DOI Scopus4 WoS4
    2016 Wang, X., & Proud, C. (2016). Erratum : mTORC2 is a tyrosine kinase (Cell Research (2016) 26 (1-2) DOI:10.1038/cr.2015.134). Cell Research, 26(2), 266.
    DOI Scopus1 WoS1 Europe PMC1
    2016 Fritzen, A., Frøsig, C., Jeppesen, J., Jensen, T., Lundsgaard, A., Serup, A., . . . Kiens, B. (2016). Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle. Cellular Signalling, 28(6), 663-674.
    DOI Scopus22 WoS19 Europe PMC14
    2016 Kenney, J., Genheden, M., Moon, K., Wang, X., Foster, L., & Proud, C. (2016). Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons. Journal of Neurochemistry, 136(2), 276-284.
    DOI Scopus16 WoS14 Europe PMC11
    2015 Wortham, N., & Proud, C. (2015). EIF2B: Recent structural and functional insights into a key regulator of translation. Biochemical Society Transactions, 43(6), 1234-1240.
    DOI Scopus20 WoS20 Europe PMC13
    2015 Wortham, N., & Proud, C. (2015). Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease. BMC Medical Genetics, 16(1), 64-1-64-8.
    DOI Scopus6 WoS5 Europe PMC5
    2015 Chen, J., Zhang, X., & Proud, C. (2015). Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice. Science Signaling, 8(392), pe1-1-pe1-3.
    DOI Scopus22 WoS17 Europe PMC12
    2015 Proud, C. (2015). Mnks, eIF4E phosphorylation and cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1849(7), 766-773.
    DOI Scopus45 WoS40 Europe PMC26
    2015 Zhang, Z., Liu, R., Townsend, P., & Proud, C. (2015). Corrigendum to "p90RSKs mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes" [J Mol Cell Cardiol 59 (2013) 139-147]. Journal of Molecular and Cellular Cardiology, 84, 227-228.
    DOI
    2015 Bommer, U., Iadevaia, V., Chen, J., Knoch, B., Engel, M., & Proud, C. (2015). Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. Cellular Signalling, 27(8), 1557-1568.
    DOI Scopus19 WoS14 Europe PMC9
    2015 Genheden, M., Kenney, J., Johnston, H., Manousopoulou, A., Garbis, S., & Proud, C. (2015). BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1. The Journal of Neuroscience, 35(3), 972-984.
    DOI Scopus39 WoS37 Europe PMC27
    2015 Xie, J., Mikolajek, H., Pigott, C., Hooper, K., Mellows, T., Moore, C., . . . Proud, C. (2015). Molecular mechanism for the control of eukaryotic elongation factor 2 kinase by pH: role in cancer cell survival. Molecular and Cellular Biology, 35(10), 1805-1824.
    DOI Scopus18 WoS18 Europe PMC12
    2015 Beggs, J., Tian, S., Jones, G., Xie, J., Iadevaia, V., Jenei, V., . . . Proud, C. (2015). The MAP kinase-interacting kinases regulate cell migration, vimentin expression and elF4E/CYFIP1 binding. Biochemical Journal, 467(1), 63-76.
    DOI Scopus33 WoS30 Europe PMC23
    2015 Stewart, J., Cowan, J., Perry, L., Coldwell, M., & Proud, C. (2015). ABC50 mutants modify translation start codon selection. Biochemical Journal, 467(2), 217-229.
    DOI Scopus8 WoS7 Europe PMC3
    2015 Wang, X., Xie, J., Da Mota, S., Moore, C., & Proud, C. (2015). Regulated stability of Eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity. Biochemical Journal, 467(2), 321-331.
    DOI Scopus6 WoS6 Europe PMC4
    2015 Moore, C., Mikolajek, H., Da Mota, S., Wang, X., Kenney, J., Werner, J., & Proud, C. (2015). Elongation factor 2 kinase is regulated by proline hydroxylation and protects cells during hypoxia. Molecular and Cellular Biology, 35(10), 1788-1804.
    DOI Scopus29 WoS27 Europe PMC20
    2015 Proud, C. (2015). Regulation and roles of elongation factor 2 kinase. Biochemical Society Transactions, 43(3), 328-332.
    DOI Scopus31 WoS29 Europe PMC17
    2015 Kenney, J., Sorokina, O., Genheden, M., Sorokin, A., Douglas Armstrong, J., & Proud, C. (2015). Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity. Journal of Neuroscience, 35(7), 3034-3037.
    DOI Scopus10 WoS10 Europe PMC6
    2014 Iadevaia, V., Liu, R., & Proud, C. (2014). MTORC1 signaling controls multiple steps in ribosome biogenesis. Seminars in Cell and Developmental Biology, 36, 113-120.
    DOI Scopus73 WoS72 Europe PMC55
    2014 Averous, J., Lambert-Langlais, S., Carraro, V., Gourbeyre, O., Parry, L., B'Chir, W., . . . Fafournoux, P. (2014). Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids. Cellular Signalling, 26(9), 1918-1927.
    DOI Scopus26 WoS28 Europe PMC19
    2014 Kenney, J., Moore, C., Wang, X., & Proud, C. (2014). Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles. Advances in Biological Regulation, 55, 15-27.
    DOI Scopus70 Europe PMC49
    2014 Moore, C., Da Mota, S., Mikolajek, H., & Proud, C. (2014). A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity. Molecular and Cellular Biology, 34(12), 2294-2307.
    DOI Scopus12 WoS11 Europe PMC11
    2014 Wortham, N., Martinez, M., Gordiyenko, Y., Robinson, C., & Proud, C. (2014). Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation. The FASEB Journal, 28(5), 2225-2237.
    DOI Scopus31 WoS29 Europe PMC25
    2014 Liu, R., Iadevaia, V., Averous, J., Taylor, P., Zhang, Z., & Proud, C. (2014). Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Research, 42(8), 5083-5096.
    DOI Scopus21 WoS21 Europe PMC16
    2014 Zhang, P., Riazy, M., Gold, M., Tsai, S., McNagny, K., Proud, C., & Duronio, V. (2014). Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation. Canadian Journal of Cardiology, 30(12), 1684-1688.
    DOI Scopus4 WoS2 Europe PMC1
    2014 Diab, S., Kumarasiri, M., Yu, M., Teo, T., Proud, C., Milne, R., & Wang, S. (2014). MAP kinase-interacting kinases - emerging targets against cancer. Chemistry & Biology, 21(4), 441-452.
    DOI Scopus54 WoS53 Europe PMC36
    2014 Gismondi, A., Caldarola, S., Lisi, G., Juli, G., Chellini, L., Iadevaia, V., . . . Loreni, F. (2014). Ribosomal stress activates eEF2K-eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes. Nucleic Acids Research, 42(20), 12668-12680.
    DOI Scopus23 WoS19 Europe PMC16
    2014 Proud, C. (2014). Control of the translational machinery by amino acids. American Journal of Clinical Nutrition, 99(1), 231S-236S.
    DOI Scopus24 WoS23 Europe PMC15
    2014 Wang, X., da Mota, S., Liu, R., Moore, C., Xie, J., Lanucara, F., . . . Proud, C. (2014). Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling. Molecular and Cellular Biology, 34(22), 4088-4103.
    DOI Scopus43 WoS38 Europe PMC25
    2014 Panja, D., Kenney, J., D'Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., . . . Bramham, C. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Reports, 9(4), 1430-1445.
    DOI Scopus57 WoS61 Europe PMC43
    2014 Versele, M., Moore, C., Proud, C. G., Rockx, C., Van de Weyer, I., Van Baelen, K., . . . Hait, W. N. (2014). Managing stress: Discovery of inhibitors of the atypical kinase eEF2K and the class III PI3K, VPS34. CANCER RESEARCH, 74(19), 1 page.
    DOI WoS1
    2014 Xie, J., & Proud, C. (2014). Signaling crosstalk between the mTOR complexes.. Translation (Austin, Tex.), 2(1), e28174.
    DOI Europe PMC11
    2013 Stead, R., & Proud, C. (2013). Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). FEBS Letters, 587(16), 2623-2628.
    DOI Scopus27 WoS24 Europe PMC20
    2013 Proud, C. (2013). MTORC1 regulates the efficiency and cellular capacity for protein synthesis. Biochemical Society Transactions, 41(4), 923-926.
    DOI Scopus7 WoS7 Europe PMC7
    2013 Leprivier, G., Remke, M., Rotblat, B., Dubuc, A., Mateo, A., Kool, M., . . . Sorensen, P. (2013). XThe eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell, 153(5), 1064-1079.
    DOI Scopus199 WoS186 Europe PMC151
    2013 Zhang, Z., Liu, R., Townsend, P., & Proud, C. (2013). p90<sup>RSK</sup>s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes. Journal of Molecular and Cellular Cardiology, 59, 139-147.
    DOI Scopus15 WoS16 Europe PMC12
    2013 Xie, J., & Proud, C. (2013). Crosstalk between mTOR complexes. Nature Cell Biology, 15(11), 1263-1265.
    DOI Scopus27 WoS23 Europe PMC18
    2013 Yadav, R., Burgos, P., Parker, A., Iadevaia, V., Proud, C., Allen, R., . . . Botchway, S. (2013). mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging. BMC Cell Biology, 14(3), 3-1-3-16.
    DOI Scopus36 WoS33 Europe PMC29
    2012 Iadevaia, V., Zhang, Z., Jan, E., & Proud, C. (2012). mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Research, 40(6), 2527-2539.
    DOI Scopus48 WoS46 Europe PMC40
    2012 Kruiswijk, F., Yuniati, L., Magliozzi, R., Low, T., Lim, R., Bolder, R., . . . Guardavaccaro, D. (2012). Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Science Signaling, 5(227), 1-12.
    DOI Scopus53 WoS52 Europe PMC45
    2012 Gal-Ben-Ari, S., Kenney, J., Ounalla-Saad, H., Tahal, E., David, O., Levitan, D., . . . Rosenblum, K. (2012). Consolidation and translation regulation. Learning & Memory, 19(9), 410-422.
    DOI Scopus51 WoS53 Europe PMC43
    2012 Hernandez, G., Proud, C., Preiss, T., & Parsyan, A. (2012). On the diversification of the translation apparatus across eukaryotes. Comparative and Functional Genomics, 2012, 1-14.
    DOI Scopus16 WoS9 Europe PMC9
    2012 Pigott, C., Mikolajek, H., Moore, C., Finn, S., Phippen, C., Werner, J., & Proud, C. (2012). Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains. Biochemical Journal, 442(1), 105-118.
    DOI Scopus30 WoS27 Europe PMC23
    2012 Gildish, I., Manor, D., David, O., Sharma, V., Williams, D., Agarwala, U., . . . Rosenblum, K. (2012). Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Learning & Memory, 19(3), 116-125.
    DOI Scopus35 WoS32 Europe PMC27
    2012 Pyr Dit Ruys, S., Wang, X., Smith, E., Herinckx, G., Hussain, N., Rider, M., . . . Proud, C. (2012). Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase. Biochemical Journal, 442(3), 681-692.
    DOI Scopus36 WoS35 Europe PMC28
    2012 Iadevaia, V., Wang, X., Yao, Z., Foster, L., & Proud, C. (2012). Evaluation of mTOR-regulated mRNA translation. Methods in Molecular Biology, 821, 171-185.
    DOI Scopus13 Europe PMC9
    2012 Proud, C. (2012). Vanishing white matter: the next 10 years. Future Neurology, 7(1), 81-92.
    DOI Scopus3
    2012 Huo, Y., Iadevaia, V., Yao, Z., Kelly, I., Cosulich, S., Guichard, S., . . . Proud, C. (2012). Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis. Biochemical Journal, 444(1), 141-151.
    DOI Scopus54 WoS55 Europe PMC42
    2012 Iadevaia, V., Huo, Y., Zhang, Z., Foster, L., & Proud, C. (2012). Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis. Biochemical Society Transactions, 40(1), 168-172.
    DOI Scopus45 WoS42 Europe PMC39
    2012 Hou, J., Lam, F., Proud, C., & Wang, S. (2012). Targeting Mnks for cancer therapy. Oncotarget, 3(2), 118-131.
    DOI Scopus103 WoS93 Europe PMC66
    2012 Cavell, B., Alwi, S., Donlevy, A., Proud, C., & Packham, G. (2012). Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2. Journal of Natural Products, 75(6), 1051-1057.
    DOI Scopus17 WoS16 Europe PMC12
    2012 Pyr Dit Ruys, S., Wang, X., Smith, E., Herinckx, G., Hussain, N., Rider, M., . . . Proud, C. (2012). Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase (Biochemical Journal (2012) 442, (681-692)). Biochemical Journal, 443(1), 328.
    Scopus1
    2012 Ruys, S. P. D., Wang, X., Smith, E., Herinckx, G., Hussain, N., Rider, M., . . . Proud, C. (2012). Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase (vol 442, pg 681, 2012). BIOCHEMICAL JOURNAL, 443, 328.
    WoS1
    2012 Wang, X., Wortham, N., Liu, R., & Proud, C. (2012). Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex. Journal of Biological Chemistry, 287(11), 8263-8274.
    DOI Scopus12 WoS11 Europe PMC10
    2011 Wang, X., & Proud, C. (2011). MTORC1 signaling: What we still dont know. Journal of Molecular Cell Biology, 3(4), 206-220.
    DOI Scopus97 WoS97 Europe PMC75
    2011 Matsukawa, T., Wang, X., Liu, R., Wortham, N., Onuki, Y., Kubota, A., . . . Tsuji, S. (2011). Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5. Neurogenetics, 12(3), 259-261.
    DOI Scopus17 WoS16 Europe PMC13
    2011 Leng, X., Wu, Y., Wang, X., Pan, Y., Wang, J., Li, J., . . . Jiang, Y. (2011). Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bε (eIF2Bε) identified in Chinese patients with vanishing white matter disease. Journal of Human Genetics, 56(4), 300-305.
    DOI Scopus12 WoS11 Europe PMC5
    2011 Proud, C. (2011). A New Link in the Chain from Amino Acids to mTORC1 Activation. Molecular Cell, 44(1), 7-8.
    DOI Scopus6 WoS7 Europe PMC6
    2011 Fonseca, B., Alain, T., Finestone, L., Huang, B., Rolfe, M., Jiang, T., . . . Proud, C. (2011). Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90RSK in the control of mTORC1 protein. Journal of Biological Chemistry, 286(31), 27111-27122.
    DOI Scopus34 WoS33 Europe PMC30
    2011 Liu, R., van der Lei, H., Wang, X., Wortham, N., Tang, H., van Berkel, C., . . . Proud, C. (2011). Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes. Human Mutation, 32(9), 1036-1045.
    DOI Scopus38 WoS34 Europe PMC28
    2011 Huo, Y., Iadevaia, V., & Proud, C. (2011). Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis. Biochemical Society Transactions, 39(2), 446-450.
    DOI Scopus26 WoS25 Europe PMC24
    2011 Wilson, G., Layman, D., Moulton, C., Norton, L., Anthony, T., Proud, C., . . . Garlick, P. (2011). Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats. American Journal of Physiology-Endocrinology and Metabolism, 301(6), 1236-1242.
    DOI Scopus47 WoS42 Europe PMC35
    2010 Proud, C. (2010). mTORC1 and cell cycle control. Unknown Journal, 27(C), 129-146.
    DOI Scopus2
    2009 Wang, X., Fonseca, B., Tang, H., Liu, R., Elia, A., Clemens, M., . . . Proud, C. (2009). How do amino acids regulate mTORC1 signaling?. AMINO ACIDS, 37(1), 67.
    2009 Wang, X., Paytubi, S., Lam, Y., Izquierdo, L., Hunter, M., Jan, E., . . . Proud, C. (2009). ABC50 promotes translation initiation in mammalian cells. Journal of Biological Chemistry, 284(36), 24061-24073.
    DOI Scopus50 WoS52 Europe PMC38
    2009 Huang, B., Wang, Y., Wang, X., Wang, Z., & Proud, C. (2009). Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes. American Journal of Physiology-Heart and Circulatory Physiology, 296(2), 505-514.
    DOI Scopus17 WoS17 Europe PMC13
    2009 Proud, C. (2009). Dynamic balancing: Deptor tips the scales. Journal of Molecular Cell Biology, 1(2), 61-63.
    DOI Scopus25 WoS25 Europe PMC22
    2009 Wang, X., & Proud, C. (2009). Nutrient control of TORC1, a cell-cycle regulator. Trends in Cell Biology, 19(6), 260-267.
    DOI Scopus129 WoS91 Europe PMC106
    2009 Hands, S., Proud, C., & Wyttenbach, A. (2009). mTOR's role in ageing: protein synthesis or autophagy?. Aging, 1(7), 586-597.
    DOI Scopus129 WoS113 Europe PMC88
    2009 Proud, C. (2009). mTORC1 signalling and mRNA translation. Biochemical Society Transactions, 37(1), 227-231.
    DOI Scopus99 WoS90 Europe PMC64
    2009 Balgi, A., Fonseca, B., Donohue, E., Tsang, T., Lajoie, P., Proud, C., . . . Roberge, M. (2009). Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One, 4(9), e712.
    DOI Scopus241 WoS230 Europe PMC169
    2009 Goto, S., Yao, Z., & Proud, C. (2009). The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. Biochemical Journal, 423(2), 279-290.
    DOI Scopus12 WoS11 Europe PMC8
    2009 Chen, J., Riazy, M., Smith, E., Proud, C., Steinbrecher, U., & Duronio, V. (2009). Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase. Arteriosclerosis Thrombosis and Vascular Biology, 29(1), 92-98.
    DOI Scopus30 WoS32 Europe PMC22
    2009 Pavitt, G., & Proud, C. (2009). Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Biochemical Society Transactions, 37(6), 1298-1310.
    DOI Scopus42 WoS37 Europe PMC33
    2009 Stansfield, I., & Proud, C. (2009). The Worm Profits from Undercharging. Cell Metabolism, 9(4), 309-310.
    DOI
    2009 Wang, X., & Proud, C. G. (2009). A novel mechanism by which amino acids regulate the protein synthesis machinery. AMINO ACIDS, 37(1), 66-67.
    WoS1
    2009 Leprivier, G., Rotblat, B., Jan, E., Barokas, A., Laderoute, K., Proud, C., & Sorensen, P. (2009). ETV6-NTRK3 and K-Ras oncoproteins block eEF2 kinase activity under nutrient starvation by modulating both AMPK and p9ORSK signaling pathways.. CANCER RESEARCH, 69, 1 page.
    2008 Kim, M., Wang, F., Puthanveetil, P., Kewalramani, G., Hosseini-Beheshti, E., Ng, N., . . . Rodrigues, B. (2008). Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes. Circulation Research, 103(3), 252-260.
    DOI Scopus25 WoS25 Europe PMC20
    2008 Wang, Y., Huang, B., Luciani, D., Wang, X., Johnson, J., & Proud, C. (2008). Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes. Journal of Molecular and Cellular Cardiology, 45(6), 812-820.
    DOI Scopus20 WoS19 Europe PMC17
    2008 Averous, J., Fonseca, B., & Proud, C. (2008). Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Oncogene, 27(8), 1106-1113.
    DOI Scopus109 WoS107 Europe PMC78
    2008 Wang, X., Fonseca, B., Tang, H., Liu, R., Elia, A., Clemens, M., . . . Proud, C. (2008). Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. Journal of Biological Chemistry, 283(45), 30482-30492.
    DOI Scopus116 WoS102 Europe PMC81
    2008 Fonseca, B., Lee, V., & Proud, C. (2008). The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Biochemical Journal, 411(1), 141-149.
    DOI Scopus24 WoS21 Europe PMC21
    2008 Buxade, M., Morrice, N., Krebs, D., & Proud, C. (2008). The PSF·p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor α. Journal of Biological Chemistry, 283(1), 57-65.
    DOI Scopus55 WoS51 Europe PMC34
    2008 Paytubi, S., Morrice, N., Boudeau, J., & Proud, C. (2008). The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. Biochemical Journal, 409(1), 223-231.
    DOI Scopus18 WoS18 Europe PMC14
    2008 Buxade, M., Parra-Palau, J., & Proud, C. (2008). The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Frontiers in Bioscience, 13(14), 5359-5374.
    DOI Scopus108 WoS105 Europe PMC75
    2008 Lee, V., Healy, T., Fonseca, B., Hayashi, A., & Proud, C. (2008). Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1. FEBS Journal, 275(9), 2185-2199.
    DOI Scopus22 WoS23 Europe PMC20
    2008 Smith, E., & Proud, C. (2008). cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner. EMBO Journal, 27(7), 1005-1016.
    DOI Scopus63 WoS59 Europe PMC46
    2008 Wang, X., & Proud, C. (2008). A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. Molecular and Cellular Biology, 28(5), 1429-1442.
    DOI Scopus42 WoS41 Europe PMC35
    2007 Fonseca, B., Smith, E., Lee, V., MacKintosh, C., & Proud, C. (2007). PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. Journal of Biological Chemistry, 282(34), 24514-24524.
    DOI Scopus178 WoS173 Europe PMC140
    2007 Proud, C. (2007). mTOR, unleashed. Science, 318(5852), 926-927.
    DOI Scopus32 WoS33 Europe PMC24
    2007 Hayashi, A., & Proud, C. (2007). The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. American Journal of Physiology - Endocrinology and Metabolism, 292(6), E1647-E1655.
    DOI Scopus74 WoS67 Europe PMC53
    2007 Proud, C. (2007). A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor.. The Biochemical journal, 401(1), e1-e3.
    DOI Scopus4 Europe PMC4
    2007 Proud, C. (2007). Signalling to translation: How signal transduction pathways control the protein synthetic machinery. Biochemical Journal, 403(2), 217-234.
    DOI Scopus370 WoS363 Europe PMC271
    2007 Scheper, G., Van Der Knaap, M., & Proud, C. (2007). Translation matters: Protein synthesis defects in inherited disease. Nature Reviews Genetics, 8(9), 711-723.
    DOI Scopus162 WoS162 Europe PMC134
    2007 Paschen, W., Proud, C., & Mies, G. (2007). Shut-down of translation, a global neuronal stress response: Mechanisms and pathological relevance. Current Pharmaceutical Design, 13(18), 1887-1902.
    DOI Scopus24 WoS25 Europe PMC17
    2006 Proud, C. (2006). Oncogene: Introduction. Oncogene, 25(48), 6346.
    DOI Scopus2 WoS2
    2006 Fierro-Monti, I., Mohammed, S., Matthiesen, R., Santoro, R., Burns, J., Williams, D., . . . Roepstorff, P. (2006). Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E. Journal of Proteome Research, 5(6), 1367-1378.
    DOI Scopus37 WoS34 Europe PMC25
    2006 Wang, X., & Proud, C. (2006). The mTOR pathway in the control of protein synthesis. Physiology, 21(5), 362-369.
    DOI Scopus360 WoS341 Europe PMC259
    2006 Conte, M., Kelly, G., Babon, J., & Proud, C. (2006). Resonance assignment for the N-terminal region of the eukaryotic initiation factor 5 (eIF5) [40]. Journal of Biomolecular NMR, 36(SUPPL. 1), 42.
    DOI
    2006 Averous, J., & Proud, C. (2006). When translation meets transformation: The mTOR story. Oncogene, 25(48), 6423-6435.
    DOI Scopus155 WoS141 Europe PMC109
    2006 Conte, M., Kelly, G., Babon, J., Sanfelice, D., Youell, J., Smerdon, S., & Proud, C. (2006). Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. Biochemistry, 45(14), 4550-4558.
    DOI Scopus35 WoS35 Europe PMC30
    2006 Scheper, G., Proud, C., & van der Knaap, M. (2006). Defective translation initiation causes vanishing of cerebral white matter. Trends in Molecular Medicine, 12(4), 159-166.
    DOI Scopus26 WoS26 Europe PMC21
    2006 Van Kollenburg, B., Thomas, A., Vermeulen, G., Bertrand, G., Van Berkel, C., Pronk, J., . . . Scheper, G. (2006). Regulation of protein synthesis in lymphoblasts from vanishing white matter patients. Neurobiology of Disease, 21(3), 496-504.
    DOI Scopus35 WoS33 Europe PMC29
    2006 Proud, C. (2006). Guest editor. Oncogene, 25(48), 6345.
    DOI
    2005 Smith, E., Finn, S., Tee, A., Brownei, G., & Proud, C. (2005). The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. Journal of Biological Chemistry, 280(19), 18717-18727.
    DOI Scopus268 WoS267 Europe PMC219
    2005 Rolfe, M., McLeod, L., Pratt, P., & Proud, C. (2005). Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochemical Journal, 388(3), 973-984.
    DOI Scopus91 WoS91 Europe PMC71
    2005 Parra-Palau, J., Scheper, G., Harper, D., & Proud, C. (2005). The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo. Biochemical Journal, 385(3), 695-702.
    DOI Scopus14 WoS11 Europe PMC8
    2005 Rose, A., Broholm, C., Kiillerich, K., Finn, S., Proud, C., Rider, M., . . . Kiens, B. (2005). Exercise rapidly increase eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. Journal of Physiology, 569(1), 223-228.
    DOI Scopus67 WoS62 Europe PMC52
    2005 Parra, J., Buxadé, M., & Proud, C. (2005). Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. Journal of Biological Chemistry, 280(45), 37623-37633.
    DOI Scopus44 WoS42 Europe PMC26
    2005 Buxadé, M., Parra, J., Rousseau, S., Shpiro, N., Marquez, R., Morrice, N., . . . Proud, C. (2005). The Mnks are novel components in the control of TNFα biosynthesis and phosphorylate and regulate hnRNP A1. Immunity, 23(2), 177-189.
    DOI Scopus145 WoS138 Europe PMC105
    2005 Tee, A., Blenis, J., & Proud, C. (2005). Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Letters, 579(21), 4763-4768.
    DOI Scopus70 WoS64 Europe PMC56
    2005 Proud, C. (2005). The eukaryotic initiation factor 4E-binding proteins and apoptosis. Cell Death and Differentiation, 12(6), 541-546.
    DOI Scopus23 WoS20 Europe PMC13
    2005 Proud, C. (2005). eIF2 and the control of cell physiology. Seminars in Cell and Developmental Biology, 16(1), 3-12.
    DOI Scopus265 WoS257 Europe PMC204
    2005 Proud, C. (2005). Seminars in Cell and Developmental Biology: Editorial. Seminars in Cell and Developmental Biology, 16(1), 1-2.
    DOI WoS3
    2005 Wang, X., Beugnet, A., Murakami, M., Yamanaka, S., & Proud, C. (2005). Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Molecular and Cellular Biology, 25(7), 2558-2572.
    DOI Scopus176 WoS169 Europe PMC137
    2004 Abbott, C., & Proud, C. (2004). Translation factors: In sickness and in health. Trends in Biochemical Sciences, 29(1), 25-31.
    DOI Scopus44 WoS36 Europe PMC22
    2004 Caldarola, S., Amaldi, F., Proud, C., & Loreni, F. (2004). Translational Regulation of Terminal Oligopyrimidine mRNAs Induced by Serum and Amino Acids Involves Distinct Signaling Events. Journal of Biological Chemistry, 279(14), 13522-13531.
    DOI Scopus30 WoS28 Europe PMC23
    2004 Browne, G., & Proud, C. (2004). A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin. Molecular and Cellular Biology, 24(7), 2986-2997.
    DOI Scopus186 WoS179 Europe PMC139
    2004 Li, W., Wang, X., Van Der Knaap, M., & Proud, C. (2004). Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways. Molecular and Cellular Biology, 24(8), 3295-3306.
    DOI Scopus76 WoS72 Europe PMC57
    2004 Proud, C. (2004). Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy. Cardiovascular Research, 63(3), 403-413.
    DOI Scopus114 WoS104 Europe PMC71
    2004 Chan, A., Soltys, C., Young, M., Proud, C., & Dyck, J. (2004). Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. Journal of Biological Chemistry, 279(31), 32771-32779.
    DOI Scopus233 WoS230 Europe PMC185
    2004 Browne, G., Finn, S., & Proud, C. (2004). Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398. Journal of Biological Chemistry, 279(13), 12220-12231.
    DOI Scopus229 WoS218 Europe PMC167
    2004 Proud, C. (2004). The multifaceted role of mTOR in cellular stress responses. DNA Repair, 3(8-9), 927-934.
    DOI Scopus68 WoS63 Europe PMC46
    2004 Hafizi, S., Wang, X., Chester, A., Yacoub, M., & Proud, C. (2004). ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. American Journal of Physiology - Heart and Circulatory Physiology, 287(3 56-3), H1232-H1238.
    DOI Scopus35 WoS34 Europe PMC27
    2003 Beugnet, A., Tee, A., Taylor, P., & Proud, C. (2003). Erratum: Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability (Biochemical Journal (2003) 372 (555-566)). Biochemical Journal, 373(3), 999.
    Scopus1
    2003 Valovka, T., Verdier, F., Cramer, R., Zhyvoloup, A., Fenton, T., Rebholz, H., . . . Gout, I. (2003). Protein kinase C phosphorylates ribosomal protein S6 kinase βII and regulates its subcellular localization. Molecular and Cellular Biology, 23(3), 852-863.
    DOI Scopus55 WoS47 Europe PMC37
    2003 Wang, L., Rolfe, M., & Proud, C. (2003). Ca<sup>2+</sup>-independent protein kinase C activity is required for α<inf>1</inf>-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. Biochemical Journal, 373(2), 603-611.
    DOI Scopus25 WoS25 Europe PMC17
    2003 Beugnet, A., Tee, A., Taylor, P., & Proud, C. (2003). Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability (vol 372, pg 555, 2003). BIOCHEMICAL JOURNAL, 373, 999.
    2003 Beugnet, A., Tee, A., Taylor, P., & Proud, C. (2003). Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochemical Journal, 372(2), 555-566.
    DOI Scopus221 WoS210 Europe PMC172
    2003 Tang, X., Wang, L., Proud, C., & Downes, C. (2003). Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: Permissive role of phosphoinositide 3-kinase. Biochemical Journal, 374(1), 137-143.
    DOI Scopus29 WoS26 Europe PMC20
    2003 Van Der Knaap, M., Van Berkel, C., Herms, J., Van Coster, R., Baethmann, M., Naidu, S., . . . Pronk, J. (2003). elF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs. American Journal of Human Genetics, 73(5), 1199-1207.
    DOI Scopus105 WoS97 Europe PMC68
    2003 Wang, X., Li, W., Parra, J., Beugnet, A., & Proud, C. (2003). The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Molecular and Cellular Biology, 23(5), 1546-1557.
    DOI Scopus78 WoS71 Europe PMC58
    2003 Parra-Palau, J., Scheper, G., Wilson, M., & Proud, C. (2003). Features in the N and C Termini of the MAPK-interacting Kinase Mnk1 Mediate Its Nucleocytoplasmic Shuttling. Journal of Biological Chemistry, 278(45), 44197-44204.
    DOI Scopus36 WoS33 Europe PMC18
    2003 Scheper, G., Parra, J., Wilson, M., Van Kollenburg, B., Vertegaal, A., Han, Z., & Proud, C. (2003). The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Molecular and Cellular Biology, 23(16), 5692-5705.
    DOI Scopus74 WoS72 Europe PMC53
    2003 Beugnet, A., Wang, X., & Proud, C. (2003). Target of Rapamycin (TOR)-signaling and RAIP Motifs Play Distinct Roles in the Mammalian TOR-dependent Phosphorylation of Initiation Factor 4E-binding Protein. Journal of Biological Chemistry, 278(42), 40717-40722.
    DOI Scopus90 WoS81 Europe PMC64
    2002 Wang, X., Janmaat, M., Beugnet, A., Paulin, F., & Proud, C. (2002). Evidence that the dephosphorylation of Ser<sup>535</sup> in the ε-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. Biochemical Journal, 367(2), 475-481.
    DOI Scopus35 WoS33 Europe PMC25
    2002 Horman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., . . . Rider, M. (2002). Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Current Biology, 12(16), 1419-1423.
    DOI Scopus331 WoS319 Europe PMC254
    2002 Kleijn, M., Scheper, G., Wilson, M., Tee, A., & Proud, C. (2002). Localisation and regulation of the eIF4E-binding protein 4E-BP3. FEBS Letters, 532(3), 319-323.
    DOI Scopus19 WoS17 Europe PMC12
    2002 Scheper, G., Van Kollenburg, B., Hu, J., Luo, Y., Goss, D., & Proud, C. (2002). Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. Journal of Biological Chemistry, 277(5), 3303-3309.
    DOI Scopus186 WoS183 Europe PMC124
    2002 Proud, C. (2002). Control of the translational machinery in mammalian cells. European Journal of Biochemistry, 269(22), 5337.
    DOI Scopus14 WoS14 Europe PMC10
    2002 Kleijn, M., & Proud, C. (2002). The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.. BMC biochemistry [electronic resource], 3(1), 11.
    DOI Scopus8 WoS10 Europe PMC6
    2002 Wang, L., & Proud, C. (2002). Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes. Circulation Research, 91(9), 821-829.
    DOI Scopus111 WoS102 Europe PMC77
    2002 Scheper, G., & Proud, C. (2002). Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?. European Journal of Biochemistry, 269(22), 5350-5359.
    DOI Scopus239 WoS220 Europe PMC169
    2002 McLeod, L., & Proud, C. (2002). ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. FEBS Letters, 531(3), 448-452.
    DOI Scopus49 WoS41 Europe PMC33
    2002 Mengesdorf, T., Proud, C., Mies, G., & Paschen, W. (2002). Mechanisms underlying suppression of protein synthesis induced by transient focal cerebral ischemia in mouse brain. Experimental Neurology, 177(2), 538-546.
    DOI Scopus49 WoS50 Europe PMC36
    2002 Proud, C. (2002). Regulation of mammalian translation factors by nutrients. European Journal of Biochemistry, 269(22), 5338-5349.
    DOI Scopus288 WoS276 Europe PMC192
    2002 Wang, L., & Proud, C. (2002). Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes. FEBS Letters, 531(2), 285-289.
    DOI Scopus43 WoS37 Europe PMC31
    2002 Tee, A., & Proud, C. (2002). Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Molecular and Cellular Biology, 22(6), 1674-1683.
    DOI Scopus103 WoS95 Europe PMC72
    2002 Kleijn, M., & Proud, C. (2002). The regulation of protein synthesis and translation factors by CD3 andCD28in human primary T lymphocytes. BMC Biochemistry, 3, 1-12.
    DOI Scopus8
    2002 Herbert, T., Tee, A., & Proud, C. (2002). The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. Journal of Biological Chemistry, 277(13), 11591-11596.
    DOI Scopus149 WoS147 Europe PMC111
    2002 Patel, J., McLeod, L., Vries, R., Flynn, A., Wang, X., & Proud, C. (2002). Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. European Journal of Biochemistry, 269(12), 3076-3085.
    DOI Scopus130 WoS129 Europe PMC101
    2002 Browne, G., & Proud, C. (2002). Regulation of peptide-chain elongation in mammalian cells. European Journal of Biochemistry, 269(22), 5360-5368.
    DOI Scopus338 WoS319 Europe PMC245
    2002 Christie, G., Hajduch, E., Hundal, H., Proud, C., & Taylor, P. (2002). Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner. Journal of Biological Chemistry, 277(12), 9952-9957.
    DOI Scopus101 WoS95 Europe PMC76
    2002 Campbell, L., & Proud, C. (2002). Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases. FEBS Letters, 510(1-2), 31-36.
    DOI Scopus56 WoS55 Europe PMC44
    2001 Scheper, G., Morrice, N., Kleijn, M., & Proud, C. (2001). The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Molecular and Cellular Biology, 21(3), 743-754.
    DOI Scopus152 WoS148 Europe PMC113
    2001 Li, W., Belsham, G., & Proud, C. (2001). Eukaryotic Initiation Factors 4A (eIF4A) and 4G (eIF4G) Mutually Interact in a 1:1 Ratio in Vivo. Journal of Biological Chemistry, 276(31), 29111-29115.
    DOI Scopus31 WoS31 Europe PMC24
    2001 Wang, L., Gout, I., & Proud, C. (2001). Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways: MEK-dependent activation of S6K2 in cardiomyocytes. Journal of Biological Chemistry, 276(35), 32670-32677.
    DOI Scopus105 WoS106 Europe PMC77
    2001 Wang, X., Paulin, F., Campbell, L., Gomez, E., O'Brien, K., Morrice, N., & Proud, C. (2001). Eukaryotic initiation factor 2B: Identification of multiple phosphorylation sites in the ε-subunit and their functions in vivo. EMBO Journal, 20(16), 4349-4359.
    DOI Scopus87 WoS85 Europe PMC68
    2001 Williams, D., Price, N., Loughlin, A., & Proud, C. (2001). Characterization of the Mammalian Initiation Factor eIF2B Complex as a GDP Dissociation Stimulator Protein. Journal of Biological Chemistry, 276(27), 24697-24703.
    DOI Scopus38 WoS37 Europe PMC28
    2001 Li, W., Ross-Smith, N., Proud, C., & Belsham, G. (2001). Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: Identification of the eIF4AI cleavage site. FEBS Letters, 507(1), 1-5.
    DOI Scopus40 WoS41 Europe PMC26
    2001 Williams, D., Pavitt, G., & Proud, C. (2001). Characterization of the Initiation Factor eIF2B and Its Regulation in Drosophila melanogaster. Journal of Biological Chemistry, 276(6), 3733-3742.
    DOI Scopus37 WoS33 Europe PMC23
    2001 Proud, C., Wang, X., Patel, J., Campbell, L., Kleijn, M., Li, W., & Browne, G. (2001). Interplay between insulin and nutrients in the regulation of translation factors. Biochemical Society Transactions, 29(4), 541-547.
    DOI Scopus44 WoS40 Europe PMC28
    2001 Mendez, R., Welsh, G., Kleijn, M., Myers, M., White, M., Proud, C., & Rhoads, R. (2001). Regulation of protein synthesis by insulin through IRS-1.. Progress in molecular and subcellular biology, 26, 49-93.
    Scopus7 Europe PMC3
    2001 Wang, X., Li, W., Williams, M., Terada, N., Alessi, D., & Proud, C. (2001). Regulation of elongation factor 2 kinase by p90<sup>RSK1</sup> and p70 S6 kinase. EMBO Journal, 20(16), 4370-4379.
    DOI Scopus532 WoS498 Europe PMC392
    2001 Karim, M., Hughes, J., Warwicker, J., Scheper, G., Proud, C., & McCarthy, J. (2001). A Quantitative Molecular Model for Modulation of Mammalian Translation by the eIF4E-binding Protein 1. Journal of Biological Chemistry, 276(23), 20750-20757.
    DOI Scopus66 WoS67 Europe PMC49
    2001 Wang, L., Gout, I., & Proud, C. (2001). Cross-talk between ERK and S6K signaling pathways: MEK-dependent activation of S6K2 in cardiomyocytes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 33(6), A128.
    DOI
    2001 Woods, Y., Cohen, P., Becker, W., Jakes, R., Goedert, M., Wang, X., & Proud, C. (2001). The kinase DYRK phosphorylates protein-synthesis initiation factor elF2Bε at Ser<sup>539</sup> and the microtubule-associated protein tau at Thr<sup>212</sup>: Potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochemical Journal, 355(3), 609-615.
    DOI Scopus204 WoS195 Europe PMC130
    2001 Althausen, S., Mengesdorf, T., Mies, G., Oláh, L., Nairn, A., Proud, C., & Paschen, W. (2001). Changes in the phosphorylation of initiation factor eIF-2α, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. Journal of Neurochemistry, 78(4), 779-787.
    DOI Scopus88 WoS86 Europe PMC70
    2001 Patel, J., Wang, X., & Proud, C. (2001). Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1. Biochemical Journal, 358(2), 497-503.
    DOI Scopus33 WoS30 Europe PMC22
    2001 Botella, J., Baines, I., Williams, D., Goberdhan, D., Proud, C., & Wilson, C. (2001). The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochemistry and Molecular Biology, 31(9), 839-847.
    DOI Scopus19 WoS16 Europe PMC9
    2001 McLeod, L., Wang, L., & Proud, C. (2001). β-adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity. FEBS Letters, 489(2-3), 225-228.
    DOI Scopus29 WoS26 Europe PMC23
    2001 Paulin, F., Campbell, L., O'Brien, K., Loughlin, J., & Proud, C. (2001). Eukaryotic translation initiation factor 5 (elF5) acts as a classical GTPase-activator protein. Current Biology, 11(1), 55-59.
    DOI Scopus72 WoS67 Europe PMC52
    2001 Tee, A., & Proud, C. (2001). Staurosporine inhibits phosphorylation of translational regulators linked to mTOR. Cell Death and Differentiation, 8(8), 841-849.
    DOI Scopus46 WoS42 Europe PMC28
    2001 Proud, C. (2001). Regulation of eukaryotic initiation factor eIF2B.. Progress in molecular and subcellular biology, 26, 95-114.
    Scopus59 Europe PMC36
    2000 Wang, L., Wang, X., & Proud, C. (2000). Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps. American Journal of Physiology - Heart and Circulatory Physiology, 278(4 47-4), H1056-H1068.
    DOI Scopus103 WoS104 Europe PMC71
    2000 Tyzack, J., Wang, X., Belsham, G., & Proud, C. (2000). ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner. Journal of Biological Chemistry, 275(44), 34131-34139.
    DOI Scopus80 WoS81 Europe PMC53
    2000 Broekhuis, C., Neubauer, G., Van Der Heijden, A., Mann, M., Proud, C., Van Venrooij, W., & Pruijn, G. (2000). Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Biochemistry, 39(11), 3023-3033.
    DOI Scopus37 WoS35 Europe PMC27
    2000 Christie, G., Hundal, H., Proud, C., & Taylor, P. (2000). Amino acid sensing and signalling in Xenopus laevis oocytes. JOURNAL OF PHYSIOLOGY-LONDON, 528P, 87P-88P.
    2000 Herbert, T., Fåhraeus, R., Prescott, A., Lane, D., & Proud, C. (2000). Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E. Current Biology, 10(13), 793-796.
    DOI Scopus84 WoS81 Europe PMC46
    2000 Kleijn, M., & Proud, C. (2000). The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling. FEBS Letters, 476(3), 262-265.
    DOI Scopus18 WoS18 Europe PMC15
    2000 Tee, A., & Proud, C. (2000). DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling. Oncogene, 19(26), 3021-3031.
    DOI Scopus106 WoS103 Europe PMC70
    2000 Herbert, T., Kilhams, G., Batty, I., & Proud, C. (2000). Distinct signalling pathways mediate insulin and phorbol ester- stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. Journal of Biological Chemistry, 275(15), 11249-11256.
    DOI Scopus96 WoS96 Europe PMC61
    2000 Kleijn, M., & Proud, C. (2000). Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells. Biochemical Journal, 347(2), 399-406.
    DOI Scopus33 WoS31 Europe PMC19
    2000 Davies, A., Taylor, P., & Proud, C. (2000). Phenylephrine stimulation of growth in adult cardiomyocytes is dependent upon p38 MAP kinase.. FASEB JOURNAL, 14(4), A583.
    2000 Davies, A., Taylor, P., & Proud, C. (2000). Electrically stimulated contraction of isolated adult rat cardiomyocytes increases p38 MAP kinase activation and promotes growth. JOURNAL OF PHYSIOLOGY-LONDON, 528P, 85P-86P.
    1999 Tuháčková, Z., Sovová, V., Šloncová, E., & Proud, C. (1999). Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts. International Journal of Cancer, 81(6), 963-969.
    DOI Scopus20 WoS21 Europe PMC14
    1999 Campbell, L., Wang, X., & Proud, C. (1999). Nutrients differentially regulate multiple translation factors and their control by insulin. Biochemical Journal, 344(2), 433-441.
    DOI Scopus68 WoS64 Europe PMC45
    1999 Williams, D., Marin, O., Pinna, L., & Proud, C. (1999). Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3β and Shaggy. FEBS Letters, 448(1), 86-90.
    DOI Scopus17 WoS16 Europe PMC11
    1999 Hovland, R., Eikhom, T., Proud, C., Cressey, L., Lanotte, M., Døskeland, S., & Houge, G. (1999). cAMP inhibits translation by inducing Ca<sup>2+</sup>/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Letters, 444(1), 97-101.
    DOI Scopus35 WoS34 Europe PMC20
    1998 Wang, X., Campbell, L., Miller, C., & Proud, C. (1998). Amino acid availability regulates p70 S6 kinase and multiple translation factors (vol 334, pg 261, 1998). BIOCHEMICAL JOURNAL, 335, 711.
    WoS1
    1998 Wang, X., Campbell, L., Miller, C., & Proud, C. (1998). Correction: Amino acid availability regulates p70 S6 kinase and multiple translation factors (Biochemical Journal (1998) 334, (261-267)). Biochemical Journal, 335(3), 711.
    Scopus1
    1998 Welsh, G., Hall, D., Warnes, A., Strange, P., & Proud, C. (1998). Activation of microtubule-associated protein kinase (Erk) and p70 S6 kinase by D<inf>2</inf> dopamine receptors. Journal of Neurochemistry, 70(5), 2139-2146.
    DOI Scopus62 WoS60 Europe PMC35
    1998 Welsh, G., Miller, C., Loughlin, A., Price, N., & Proud, C. (1998). Regulation of eukaryotic initiation factor eIF2B: Glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Letters, 421(2), 125-130.
    DOI Scopus226 WoS218 Europe PMC152
    1998 Kleijn, M., Welsh, G., Scheper, G., Voorma, H., Proud, C., & Thomas, A. (1998). Nerve epidermal growth factor induce protein synthesis eIF2B activation in PC12 cells. Journal of Biological Chemistry, 273(10), 5536-5541.
    DOI Scopus51 WoS50 Europe PMC36
    1998 Wang, X., Campbell, L., Miller, C., & Proud, C. (1998). Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochemical Journal, 334(1), 261-267.
    DOI Scopus273 WoS262 Europe PMC192
    1998 Wang, X., Flynn, A., Waskiewicz, A., Webb, B., Vries, R., Baines, I., . . . Proud, C. (1998). The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. Journal of Biological Chemistry, 273(16), 9373-9377.
    DOI Scopus241 WoS228 Europe PMC177
    1997 Webb, B., & Proud, C. (1997). Eukaryotic initiation factor 2B (eIF2B). International Journal of Biochemistry and Cell Biology, 29(10), 1127-1131.
    DOI Scopus71 WoS67 Europe PMC44
    1997 Shepherd, P., Nave, B., Rincon, J., Haigh, R., Foulstone, E., Proud, C., . . . Wallberg-Henriksson, H. (1997). Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP- kinase and phosphorylation of protein kinase-B in human skeletal muscle: Implications for glucose metabolism. Diabetologia, 40(10), 1172-1177.
    DOI Scopus56 WoS57 Europe PMC28
    1997 Waskiewicz, A., Flynn, A., Proud, C., & Cooper, J. (1997). Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO Journal, 16(8), 1909-1920.
    DOI Scopus692 WoS680 Europe PMC471
    1997 Wang, X., & Proud, C. (1997). p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: Roles for phosphatidylinositol 3-kinase and p38 MAP kinase. Biochemical and Biophysical Research Communications, 238(1), 207-212.
    DOI Scopus37 WoS39 Europe PMC21
    1997 Welsh, G., Stokes, C., Wang, X., Sakaue, H., Ogawa, W., Kasuga, M., & Proud, C. (1997). Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase. FEBS Letters, 410(2-3), 418-422.
    DOI Scopus85 WoS84 Europe PMC59
    1997 Rhoads, R., Mendez, R., Gan, W., White, M., Mvers, M., Welch, G., & Proud, C. (1997). Translational control at the mrna-binding step. FASEB Journal, 11(9), A1284.
    1997 Welsh, G., Patel, J., & Proud, C. (1997). Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts. Analytical Biochemistry, 244(1), 16-21.
    DOI Scopus55 WoS58 Europe PMC35
    1997 Proud, C., & Denton, R. (1997). Molecular mechanisms for the control of translation by insulin. Biochemical Journal, 328(2), 329-341.
    DOI Scopus215 WoS202 Europe PMC142
    1997 Kelly Moule, S., Welsh, G., Edgell, N., Foulstone, E., Proud, C., & Denton, R. (1997). Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β<inf>3</inf>-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms. Journal of Biological Chemistry, 272(12), 7713-7719.
    DOI Scopus218 WoS216 Europe PMC120
    1997 Welsh, G., Loughlin, A., Foulstone, E., Price, N., & Proud, C. (1997). Regulation of initiation factor elF-2B by GSK-3 regulated phosphorylation. Biochemical Society Transactions, 25(2), S191.
    DOI Scopus7 WoS6 Europe PMC4
    1997 Vries, R., Flynn, A., Patel, J., Wang, X., Denton, R., & Proud, C. (1997). Heat shock increases the association of binding protein-1 with initiation factor 4E. Journal of Biological Chemistry, 272(52), 32779-32784.
    DOI Scopus58 WoS56 Europe PMC39
    1996 Redpath, N., Foulstone, E., & Proud, C. (1996). Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO Journal, 15(9), 2291-2297.
    DOI Scopus213 WoS198 Europe PMC135
    1996 Flynn, A., & Proud, C. (1996). Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor. European Journal of Biochemistry, 236(1), 40-47.
    DOI Scopus40 WoS40 Europe PMC25
    1996 Price, N., Kimball, S., Jefferson, L., & Proud, C. (1996). Cloning of cDNA for the γ-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Biochemical Journal, 318(2), 631-636.
    DOI Scopus17 WoS17 Europe PMC11
    1996 Flynn, A., & Proud, C. (1996). The role of eIF4 in cell proliferation. Cancer Surveys, 27, 293-310.
    Scopus86 WoS81 Europe PMC45
    1996 Diggle, T., Moule, S., Avison, M., Flynn, A., Foulstone, E., Proud, C., & Denton, R. (1996). Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells. Biochemical Journal, 316(2), 447-453.
    DOI Scopus83 WoS83 Europe PMC56
    1996 Price, N., Mellor, H., Craddock, B., Flowers, K., Kimball, S., Wilmer, T., . . . Proud, C. (1996). EIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2: Sequence conservation between the α, β and δ subunits of eIF2B from mammals and yeast. Biochemical Journal, 318(2), 637-643.
    DOI Scopus24 WoS24 Europe PMC11
    1996 Gilligan, M., Welsh, G., Flynn, A., Bujalska, I., Digglell, T., Denton, R., . . . Dochertyt, K. (1996). Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. Journal of Biological Chemistry, 271(4), 2121-2125.
    DOI Scopus48 WoS45 Europe PMC37
    1996 Proud, C. (1996). p70 S6 Kinase: An enigma with variations. Trends in Biochemical Sciences, 21(5), 181-185.
    DOI Scopus196 WoS202 Europe PMC115
    1996 Welsh, G., Wilson, C., & Proud, C. (1996). GSK3: A SHAGGY frog story. Trends in Cell Biology, 6(7), 274-279.
    DOI Scopus121 WoS124 Europe PMC86
    1996 Craddock, B., & Proud, C. (1996). The α-subunit of the mammalian guanine nucleotide-exchange factor eIF-2B is essential for catalytic activity in vitro. Biochemical and Biophysical Research Communications, 220(3), 843-847.
    DOI Scopus12 WoS11 Europe PMC7
    1996 Redpath, N., Price, N., & Proud, C. (1996). Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase. Journal of Biological Chemistry, 271(29), 17547-17554.
    DOI Scopus60 WoS56 Europe PMC20
    1996 Flynn, A., & Proud, C. (1996). Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway. FEBS Letters, 389(2), 162-166.
    DOI Scopus70 WoS66 Europe PMC43
    1996 Flynn, A., Vries, R., & Proud, C. (1996). Signalling pathways which regulate eIF4E. IMMUNOLOGY, 89, G77.
    1996 Welsh, G., Loughlin, A., Stokes, C., & Proud, C. (1996). Regulation of initiation factor eIF-2B activity by GSK-3 mediated phosphorylation. IMMUNOLOGY, 89, G76.
    1996 Welsh, G., Miyamoto, S., Priced, N., Safer, B., & Proud, C. (1996). T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. Journal of Biological Chemistry, 271(19), 11410-11413.
    DOI Scopus86 WoS87 Europe PMC51
    1996 Hurme, R., Berndt, K., Namork, E., & Rhen, M. (1996). Additions and Corrections to DNA binding exerted by a bacterial gene regulator with an extensive coiled-coil domain.. The Journal of biological chemistry, 271(29), 17547.
    DOI Europe PMC13
    1995 Flynn, A., & Proud, C. (1995). Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells. Journal of Biological Chemistry, 270(37), 21684-21688.
    DOI Scopus127 WoS129 Europe PMC93
    1995 Proud, C. (1995). PKR: a new name and new roles. Trends in Biochemical Sciences, 20(6), 241-246.
    DOI Scopus194 WoS191 Europe PMC133
    1995 Craddock, B., Price, N., & Proud, C. (1995). Cloning and expression of cDNAs for the β subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2. Biochemical Journal, 309(3), 1009-1014.
    DOI Scopus11 WoS12 Europe PMC5
    1995 van den Heuvel, J., Lang, V., Richter, G., Price, N., Peacock, L., Proud, C., & McCarthy, J. (1995). The highly acidic C-terminal region of the yeast initiation factor subunit 2 α (eIF-2 α) contains casein kinase phosphorylation sites and is essential for maintaining normal regulation of GCN4. BBA - Gene Structure and Expression, 1261(3), 337-348.
    DOI Scopus11 WoS12 Europe PMC6
    1995 Moule, S., Edgell, N., Welsh, G., Diggle, T., Foulstone, E., Heesom, K., . . . Denton, R. (1995). Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. Biochemical Journal, 311(2), 595-601.
    DOI Scopus107 WoS102 Europe PMC67
    1994 Flynn, A., Shatsky, I., Proud, C., & Kaminski, A. (1994). The RNA-binding properties of protein synthesis initiation factor eIF-2. BBA - Gene Structure and Expression, 1219(2), 293-301.
    DOI Scopus12 WoS12 Europe PMC8
    1994 Welsh, G., Foulstone, E., Young, S., Tavare, J., & Proud, C. (1994). Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochemical Journal, 303(1), 15-20.
    DOI Scopus181 WoS206 Europe PMC117
    1994 Welsh, G., Price, N., Bladergroen, B., Bloomberg, G., & Proud, C. (1994). Identification of novel phosphorylation sites in the β-subunit of translation initiation factor eIF-2. Biochemical and Biophysical Research Communications, 201(3), 1279-1288.
    DOI Scopus26 WoS26 Europe PMC20
    1994 Price, N., Francia, G., Hall, L., & Proud, C. (1994). Guanine nucleotide exchange factor for eukaryotic initiation factor-2. Cloning of cDNA for the δ-subunit of rabbit translation initiation factor-2B. BBA - Gene Structure and Expression, 1217(2), 207-210.
    DOI Scopus14 WoS15 Europe PMC9
    1994 Price, N., & Proud, C. (1994). The guanine nucleotide-exchange factor, eIF-2B. Biochimie, 76(8), 748-760.
    DOI Scopus83 WoS80 Europe PMC51
    1994 OLDFIELD, S., JONES, B., TANTON, D., & PROUD, C. (1994). Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF‐2B. European Journal of Biochemistry, 221(1), 399-410.
    DOI Scopus46 WoS49 Europe PMC34
    1994 Proud, C. (1994). Turned on by insulin. Nature, 371(6500), 747-748.
    DOI Scopus47 WoS48 Europe PMC26
    1994 Proud, C. (1994). Peptide-chain elongation in eukaryotes. Molecular Biology Reports, 19(3), 161-170.
    DOI Scopus68 WoS65 Europe PMC44
    1994 Redpath, N., & Proud, C. (1994). Molecular mechanisms in the control of translation by hormones and growth factors. BBA - Molecular Cell Research, 1220(2), 147-162.
    DOI Scopus82 WoS88 Europe PMC54
    1993 REDPATH, N., PRICE, N., SEVERINOV, K., & PROUD, C. (1993). Regulation of elongation factor‐2 by multisite phosphorylation. European Journal of Biochemistry, 213(2), 689-699.
    DOI Scopus140 WoS136 Europe PMC102
    1993 Redpath, N., & Proud, C. (1993). Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity. Biochemical Journal, 293(1), 31-34.
    DOI Scopus66 WoS62 Europe PMC40
    1993 Welsh, G., & Proud, C. (1993). Evidence for a role for protein kinase C in the stimulation of protein synthesis by insulin in swiss 3T3 fibroblasts. FEBS Letters, 316(3), 241-246.
    DOI Scopus16 WoS20 Europe PMC10
    1993 Welsh, G., & Proud, C. (1993). Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochemical Journal, 294(3), 625-629.
    DOI Scopus319 WoS323 Europe PMC198
    1993 Flynn, A., Oldfield, S., & Proud, C. (1993). The role of the β-subunit of initiation factor eIF-2 in initiation complex formation. BBA - Gene Structure and Expression, 1174(1), 117-121.
    DOI Scopus29 WoS28 Europe PMC17
    1993 Oldfield, S., & Proud, C. (1993). Phosphorylation of elongation factor-2 from the lepidopteran insect, spodoptera frugiperda. FEBS Letters, 327(1), 71-74.
    DOI Scopus6 WoS6 Europe PMC6
    1993 MELLOR, H., PRICE, N., OLDFIELD, S., SARRE, T., & PROUD, C. (1993). Purification and characterisation of an initiation‐factor‐2 kinase from uninduced mouse erythroleukaemia cells. European Journal of Biochemistry, 211(3), 529-538.
    DOI Scopus9 WoS10 Europe PMC4
    1993 Sharp, T., Schwemmle, M., Jeffrey, I., Laing, K., Mellor, H., Proud, C., . . . Clemens, M. (1993). Comparative analysis of the regulation of the interferoninducible protein kinase pkr by epstein - barr virus RNAs EBER-1 and EBER-2 and adenovirus VA, RNA. Nucleic Acids Research, 21(19), 4483-4490.
    DOI Scopus152 WoS149 Europe PMC115
    1993 Price, N., Hall, L., & Proud, C. (1993). Cloning of cDNA for the β-subunit of rabbit translation initiation factor-2 using PCR. BBA - Gene Structure and Expression, 1216(1), 170-172.
    DOI Scopus6 WoS6 Europe PMC1
    1993 REDPATH, N., & PROUD, C. (1993). Purification and phosphorylation of elongation factor‐2 kinase from rabbit reticulocytes. European Journal of Biochemistry, 212(2), 511-520.
    DOI Scopus53 WoS51 Europe PMC36
    1992 Welsh, G., & Proud, C. (1992). Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors. Biochemical Journal, 284(1), 19-23.
    DOI Scopus66 WoS75 Europe PMC43
    1992 OLDFIELD, S., & PROUD, C. (1992). Purification, phosphorylation and control of the guanine‐nucleotide‐exchange factor from rabbit reticulocyte lysates. European Journal of Biochemistry, 208(1), 73-81.
    DOI Scopus66 WoS69 Europe PMC43
    1992 Proud, C. (1992). Protein Phosphorylation in Translational Control. CURRENT TOPICS IN CELLULAR REGULATION, 32(C), 243-369.
    DOI Scopus159 WoS182 Europe PMC74
    1991 Price, N., Redpath, N., Severinov, K., Campbell, D., Russell, J., & Proud, C. (1991). Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes. FEBS Letters, 282(2), 253-258.
    DOI Scopus79 WoS78 Europe PMC53
    1991 Green, S., Spalding, A., Ashford, T., Proud, C., & Tuite, M. (1991). Synthesis of human initiation factor-2α in Saccharomyces cerevisiae. Gene, 108(2), 253-258.
    DOI Scopus2 WoS2 Europe PMC1
    1991 Price, N., Welsh, G., & Proud, C. (1991). Phosphorylation of only serine-51 in protein synthesis initiation factor-2 is associated with inhibition of peptide-chain initiation in reticulocyte lysates. Biochemical and Biophysical Research Communications, 176(3), 993-999.
    DOI Scopus19 WoS21 Europe PMC10
    1991 PROUD, C., COLTHURST, D., FERRARI, S., & PINNA, L. (1991). The substrate specificity of protein kinases which phosphorylate the α subunit of eukaryotic initiation factor 2. European Journal of Biochemistry, 195(3), 771-779.
    DOI Scopus15 WoS16 Europe PMC11
    1991 Bommer, U., Kraft, R., Kurzchalia, T., Price, N., & Proud, C. (1991). Amino acid sequence analysis of the β- and γ-subunits of eukaryotic initiation factor eIF-2. Identification of regions interacting with GTP. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 1079(3), 308-315.
    DOI Scopus20 WoS25 Europe PMC11
    1991 Redpath, N., & Proud, C. (1991). Differing effects of the protein phosphatase inhibitors okadaic acid and microcystin on translation in reticulocyte lysates. BBA - Molecular Cell Research, 1093(1), 36-41.
    DOI Scopus15 WoS18 Europe PMC12
    1991 Mellor, H., & Proud, C. (1991). A synthetic peptide substrate for initiation factor-2 kinases. Biochemical and Biophysical Research Communications, 178(2), 430-437.
    DOI Scopus27 WoS27 Europe PMC21
    1990 Redpath, N., & Proud, C. (1990). Activity of protein phosphatases against initiation factor-2 and elongation factor-2. Biochemical Journal, 272(1), 175-180.
    DOI Scopus72 WoS79 Europe PMC50
    1990 Price, N., & Proud, C. (1990). Phosphorylation of protein synthesis initiation factor-2. Identification of the site in the α-subunit phosphorylated in reticulocyte lysates. BBA - Molecular Cell Research, 1054(1), 83-88.
    DOI Scopus18 WoS18 Europe PMC14
    1989 Clark, S., Ashford, A., Price, N., & Proud, C. (1989). Casein kinase-2 phosphorylates serine-2 in the β-subunit of initiation factor-2. BBA - Molecular Cell Research, 1010(3), 377-380.
    DOI Scopus11 WoS15 Europe PMC5
    1989 Redpath, N., & Proud, C. (1989). The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2. Biochemical Journal, 262(1), 69-75.
    DOI Scopus83 WoS102 Europe PMC56
    1989 Price, N., Nakielny, S., Clark, S., & Proud, C. (1989). The two forms of the β-subunit of initiation factor-2 from reticulocyte lysates arise from proteolytic degradation. BBA - Gene Structure and Expression, 1008(2), 177-182.
    DOI Scopus31 WoS35 Europe PMC25
    1988 Clark, S., Colthurst, D., & Proud, C. (1988). Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the β-subunit. BBA - Molecular Cell Research, 968(2), 211-219.
    DOI Scopus23 WoS33 Europe PMC20
    1988 Cox, S., Redpath, N., & Proud, C. (1988). Regulation of polypeptide-chain initiation in rat skeletal muscle Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2. FEBS Letters, 239(2), 333-338.
    DOI Scopus22 WoS25 Europe PMC15
    1988 Cox, S., & Proud, C. (1988). The effect of ethanol on polypeptide chain initiation in reticulocyte lysates. Inhibition of recycling of initiation factor eIF-2. Biochemical Pharmacology, 37(10), 2045-2049.
    DOI Scopus3 WoS5 Europe PMC1
    1987 Proud, C. (1987). Isolation and characterisation of the guanine nucleotide exchange factor from rat liver. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 914(1), 64-73.
    DOI Scopus8 WoS10 Europe PMC8
    1987 Clemens, M., Pain, J., & Proud, C. (1987). Initiation complexes - reply to Gupta. Trends in Biochemical Sciences, 12(C), 55.
    DOI Scopus1 WoS1
    1987 COLTHURST, D., CAMPBELL, D., & PROUD, C. (1987). Structure and regulation of eukaryotic initiation factor eIF‐2: Sequence of the site in the α subunit phosphorylated by the haem‐controlled repressor and by the double‐stranded RNA‐activated inhibitor. European Journal of Biochemistry, 166(2), 357-363.
    DOI Scopus96 WoS118 Europe PMC71
    1986 Proud, C. (1986). Guanine nucleotides, protein phosphorylation and the control of translation. Trends in Biochemical Sciences, 11(2), 73-77.
    DOI Scopus82 WoS121
    1986 Burnet, F., Proud, C., & Williams, T. (1986). Protein kinase catalysed phosphorylation of monoclonal and polyclonal immunoglobins. IRCS Medical Science, 14(3), 278-279.
    1986 Colthurst, D., & Proud, C. (1986). Eukaryotic initiation factor 2 from rat liver: no apparent function for the β-subunit in the formation of initiation complexes. BBA - Gene Structure and Expression, 868(1), 77-86.
    DOI Scopus21 WoS25 Europe PMC15
    1986 BURNET, F., PROUD, C., WILLIAMS, T., RICHARDSON, A., HEYDERMAN, E., MOUNTFORD, P., & COAKLEY, A. (1986). SELECTIVE INSERTION OF P-32 INTO IMMUNOGLOBULINS BY PROTEIN-KINASES. BRITISH JOURNAL OF CANCER, 54(3), 537.
    1985 COLTHURST, D., & PROUD, C. (1985). STRUCTURAL AND FUNCTIONAL-PROPERTIES OF PROTEIN-SYNTHESIS INITIATION-FACTORS EIF-2 AND EIF-2B FROM RAT-LIVER. BIOCHEMICAL SOCIETY TRANSACTIONS, 13(4), 756-757.
    DOI WoS2
    1985 COX, S., & PROUD, C. (1985). INITIATION OF PROTEIN-SYNTHESIS IN RAT SKELETAL-MUSCLE. BIOCHEMICAL SOCIETY TRANSACTIONS, 13(4), 755-756.
    DOI
    1984 Proud, C. (1984). Metabolite-induced activation of hepatic phosphofructokinase. Biochemical and Biophysical Research Communications, 118(2), 567-572.
    DOI Scopus4 WoS6 Europe PMC2
    1984 Harmon, C., Proud, C., & Pain, V. (1984). Effects of starvation, diabetes and acute insulin treatment on the regulation of polypeptides-chain initiation in rat skeletal muscle. Biochemical Journal, 223(3), 687-696.
    DOI Scopus59 WoS78 Europe PMC44
    1982 Proud, C., & Pain, V. (1982). Purification and phosphorylation of initiation factor eIF-2 from rabbit skeletal muscle. FEBS Letters, 143(1), 55-59.
    DOI Scopus20 WoS32 Europe PMC18
    1982 Proud, C., & Pain, V. (1982). Purification and phosphorylation of initiation factor eIF-2 from rabbit skeletal muscle.. FEBS letters, 143(1), 55-59.
    Scopus12
    1982 Proud, C., Clemens, M., & Pain, V. (1982). Regulation of binding of initiator tRNA to eukaryotic initiation factor eIF-2. Effects of the haem-controlled repressor on the kinetics of ternary complex formation. FEBS Letters, 148(2), 214-220.
    DOI Scopus15 WoS25 Europe PMC18
    1980 BRAND, I., PROUD, C., LUCK, H., & SOLING, H. (1980). NEW ASPECTS OF REGULATION OF PHOSPHOFRUCTOKINASE ACTIVITY IN LIVER. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 361(5), 610-611.
    1980 SOLING, H., LUCK, H., PROUD, C., & BRAND, I. (1980). CASCADE-LIKE CONTROL OF HEPATIC PHOSPHOFRUCTOKINASE ACTIVITY. FEDERATION PROCEEDINGS, 39(6), 1670.
    WoS4
    1978 Proud, C. (1978). The phosphorylation of rabbit skeletal-muscle glycogen synthase by cyclic AMP-dependent protein kinase. Biochemical Society Transactions, 6(5), 950-951.
    DOI
    1978 Cohen, P., Nimmo, H., & Proud, C. (1978). How does insulin stimulate glycogen synthesis?. Biochemical Society Symposia, No.43(43), 69-95.
    Scopus34 Europe PMC7
    1977 Proud, C., Rylatt, D., Yeaman, S., & Cohen, P. (1977). Amino acid sequences at the two sites on glycogen synthetase phosphorylated by cyclic AMP-dependent protein kinase and their dephosphorylation by protein phosphatase-III. FEBS Letters, 80(2), 435-442.
    DOI Scopus63 WoS104 Europe PMC41
    1976 PROUD, C., DONOVAN, D., KINSEY, R., CUNNINGHAM, P., & ZIMMERMAN, D. (1976). TESTICULAR GROWTH IN BOARS AS INFLUENCED BY SELECTION FOR OVULATION RATE. JOURNAL OF ANIMAL SCIENCE, 42(5), 1361-1362.
    WoS10
    1976 KINSEY, R., CARLSON, R., PROUD, C., & ZIMMERMAN, D. (1976). INFLUENCE OF BOAR COMPONENT STIMULI ON AGE AT PUBERTY IN GILTS. JOURNAL OF ANIMAL SCIENCE, 42(5), 1362.
    WoS9
    1976 NIMMO, H., PROUD, C., & COHEN, P. (1976). The Purification and Properties of Rabbit Skeletal Muscle Glycogen Synthase. European Journal of Biochemistry, 68(1), 21-30.
    DOI Scopus148 WoS195 Europe PMC121
    1976 NIMMO, H., PROUD, C., & COHEN, P. (1976). The Phosphorylation of Rabbit Skeletal Muscle Glycogen Synthase by Glycogen Synthase Kinase‐2 and Adenosine‐3′: 5′‐Monophosphate‐Dependent Protein Kinase. European Journal of Biochemistry, 68(1), 31-44.
    DOI Scopus70 WoS114 Europe PMC59
    1975 Cohen, P., Antoniw, J., Nimmo, H., & Proud, C. (1975). Structure and regulation of enzymes for the degradation and resynthesis of glycogen. Biochemical Society Transactions, 3(6), 849-854.
    DOI Scopus11 WoS11
  • Books

    Year Citation
    2003 Proud, C. (2003). Role of mTOR signalling in the control of translation initiation and elongation by nutrients (Vol. 279). G. Thomas, D. Sabatini, & M. Hall (Eds.), SPRINGER-VERLAG BERLIN.
    DOI Scopus89 WoS15 Europe PMC66
    2001 Proud, C. (2001). Regulation of mRNA translation (Vol. 37). K. Chapman, & S. Higgins (Eds.), PORTLAND PRESS LTD.
    DOI Scopus13 WoS12 Europe PMC7
  • Book Chapters

    Year Citation
    2013 Proud, C. (2013). mTOR and its Downstream Targets. In Encyclopedia of Biological Chemistry: Second Edition (pp. 194-199).
    DOI
    2008 Proud, C. (2008). Community Children's Nursing. In Mentorship in Community Nursing: Challenges and Opportunities (pp. 132-139).
    DOI
    2007 Wang, X., & Proud, C. (2007). Methods for Studying Signal-Dependent Regulation of Translation Factor Activity. In J. Lorsch (Ed.), Unknown Book (Vol. 431, pp. 113-142). ELSEVIER ACADEMIC PRESS INC.
    DOI Scopus31 WoS29 Europe PMC25
  • Conference Papers

    Year Citation
    2018 Tangseefa, P., Martin, S. K., Wilczek, V., Baldock, P., Proud, C. G., Fitter, S., & Zannettino, A. C. (2018). Metabolic and reproductive abnormalities in mice with impaired skeletal-mTORC1 function mirror a dietary restriction phenotype. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 19). Perth, AUSTRALIA: WILEY.
    2017 Proud, C. (2017). How do mutations in the genes for eukaryotic initiation factor 2B lead to vanishing white matter disease?. In GLIA Vol. 65 (pp. E82-E83). Edinburgh, SCOTLAND: WILEY.
    2015 Bommer, U., Vine, K., Iadevaia, V., Belfiore, L., Engel, M., Puri, P., . . . Proud, C. (2015). TCTP is induced early in colorectal cancer, it is translationally regulated via the Akt/mTORC1 pathway, and it contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin. In FEBS JOURNAL Vol. 282 (pp. 95). Berlin, GERMANY: WILEY-BLACKWELL.
    2015 Wisse, L., Penning, R., Kenney, J., Bugiani, M., Polder, E., Van Berkel, C., . . . Abbink, T. (2015). Towards the understanding of the molecular mechanism of vanishing white matter. In GLIA Vol. 63 (pp. E152-E153). Bilbao, SPAIN: WILEY.
    2011 Proud, C. (2011). mTOR signalling in health and disease. In Biochemical Society Transactions - Vol 39 Vol. 39 (pp. 431-436). Great Britain: Biochemical Society.
    DOI Scopus45 WoS43 Europe PMC38
    2008 Proud, C. (2008). mTOR signalling and human disease. In JOURNAL OF MEDICAL GENETICS Vol. 45 (pp. S33). Univ York, York, ENGLAND: BMJ PUBLISHING GROUP.
    WoS2
    2007 Proud, C. (2007). Amino acids and mTOR signalling in anabolic function. In Biochemical Society Transactions Vol. 35 (pp. 1187-1190). Glasgow, SCOTLAND: PORTLAND PRESS LTD.
    DOI Scopus91 WoS88 Europe PMC68
    2006 Proud, C. (2006). Regulation of protein synthesis by insulin. In Biochemical Society Transactions Vol. 34 (pp. 213-216). Univ Bristol, Bristol, ENGLAND: PORTLAND PRESS LTD.
    DOI Scopus151 WoS141 Europe PMC96
    2004 Rolfe, M., Mcleod, L., Pratt, P., & Proud, C. (2004). Role of MEK/ERK signalling in protein synthesis and cardiac hypertrophy. In JOURNAL OF CARDIAC FAILURE Vol. 10 (pp. S60). Toronto, CANADA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS.
    DOI
    2004 Chan, A., Soltys, C., Young, M., Proud, C., & Dyck, J. (2004). Activation of AMP-activated protein kinase inhibits cardiac myocyte hypertrophy induced by Akt. In CIRCULATION Vol. 110 (pp. 192). New Orleans, LA: LIPPINCOTT WILLIAMS & WILKINS.
    2004 Proud, C. (2004). mTOR-mediated regulation of translation factors by amino acids. In Biochemical and Biophysical Research Communications Vol. 313 (pp. 429-436). TOKYO, JAPAN: ACADEMIC PRESS INC ELSEVIER SCIENCE.
    DOI Scopus152 WoS149 Europe PMC110
    2003 Proud, C. G. (2003). Mechanisms for the control of protein synthesis in response to cell stresses. In JOURNAL OF NEUROCHEMISTRY Vol. 87 (pp. 8). WANCHAI, PEOPLES R CHINA: BLACKWELL PUBLISHING LTD.
    2003 Underhill, M., Coley, C., Birch, J., Findlay, A., Kallmeier, R., Proud, C., & James, D. (2003). Engineering mRNA translation initiation to enhance transient gene expression in Chinese hamster ovary cells. In Biotechnology Progress Vol. 19 (pp. 121-129). United States: AMER CHEMICAL SOC.
    DOI Scopus22 WoS23 Europe PMC18
    2003 Paschen, W., Mengesdorf, T., Proud, C., & Mies, G. (2003). Mechanisms underlying irreversible shut down of translation in transient focal cerebral ischemia in mouse brain. In STROKE Vol. 34 (pp. 299). PHOENIX, ARIZONA: LIPPINCOTT WILLIAMS & WILKINS.
    1999 Heaton, M., Birch, J., Hovey, A., Kallmeier, R., Proud, C., & James, D. (1999). Genetic manipulation of the protein synthetic capacity of mammalian cells. In A. Bernard, B. Griffiths, W. Noe, & F. Wurm (Eds.), ANIMAL CELL TECHNOLOGY: PRODUCTS FROM CELLS, CELLS AS PRODUCTS (pp. 31-33). LUGANO, SWITZERLAND: SPRINGER.
    1997 Flynn, A., Vries, R., & Proud, C. (1997). Signalling pathways which regulate eIF4E. In Biochemical Society Transactions Vol. 25 (pp. S192). England: PORTLAND PRESS.
    DOI Scopus11 WoS12 Europe PMC9
    1995 Moule, S., Edgell, N., Welsh, G., Diggle, T., Proud, C., & Denton, R. (1995). Studies with wortmannin indicate that insulin stimulation of lipogenesis involves multiple signalling pathways. In Biochemical Society Transactions Vol. 23 (pp. S206). UNIV SUSSEX, BRIGHTON, ENGLAND: PORTLAND PRESS LTD.
    DOI Scopus5 WoS4 Europe PMC2
Category 1 Funding

2016-18 NHMRC grant  no: 1109207

Chief Investigator: A Zannettino (CIA), P Baldock (CIB), CG Proud (CIC)

Targeting skeletal mTORC1 as a novel approach for the treatment of diet-induced insulin resistance

$600,846
 Industry Funding
2016-17 A*Start Experimental Therapeutics Centre, Singapore Chief Investigators: CG Proud (CIA) $98,850

 

I currently lecture biochemistry students at the University of Adelaide on Cancer, Cell Signalling and Development and Advanced Molecular Biology.

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Principal Supervisor Regulation of mTOR Signalling and Protein Synthesis via Parkinson's Disease Risk Factors UCHL1 and LRRK2 Master of Philosophy Master Full Time Mr Josif Bailey Dragovelic
    2018 Principal Supervisor Regulation of mTORC1 and RHEB Doctor of Philosophy Doctorate Full Time Mr Stuart Paul De Poi
    2017 Co-Supervisor The role of osteoblast-mTORC1 in the regulation of glucose metabolism and male fertility Doctor of Philosophy Doctorate Full Time Miss Pawanrat Tangseefa
    2017 Principal Supervisor The Roles of the MNK Protein Kinases in Metabolic Disease Doctor of Philosophy Doctorate Full Time Mr James Edward Merrett
    2017 Co-Supervisor The Novel Role of Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Atherosclerosis Doctor of Philosophy Doctorate Full Time Ms Sanuja Fernando
    2016 Principal Supervisor The role of Eukaryotic Elongation Factor 2 Kinase (EEF2K) in the Survival of cancer cells and Macrophages Doctor of Philosophy Doctorate Full Time Mr Roman Valeryevich Lenchine
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2015 - 2017 Principal Supervisor Novel Roles of the MAP Kinase - interacting Kinases Doctor of Philosophy Doctorate Full Time Miss Shuye Tian
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  • Committee Memberships

    Date Role Committee Institution Country
    2012 - 2015 Member Chairs and Programme Grants Committee British Heart Foundation
    1993 - 1994 Member Biochemistry Panel Former Science & Engineering Research Council
  • Consulting/Advisories

    Date Institution Department Organisation Type Country
    2013 - 2015 Wessex Medical Research
    1997 - 2000 British Heart Foundation
  • Editorial Boards

    Date Role Editorial Board Name Institution Country
    2012 - ongoing Board Member Editorial Board of F1000 Research
    2012 - ongoing Board Member Editorial Board of Translation
    2011 - ongoing Board Member Editorial Board of the Biochemical Journal
    2002 - 2005 Board Member Editorial Board of the Journal of Biological Chemistry
    1998 - 2008 Editor European Journal of Biochemistry/FEBS Journal

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