Dr Chris Brien

Christopher Brien
Senior Biostatistician
School of Agriculture, Food and Wine
Faculty of Sciences

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Dr Chris Brien

Welcome to my profile. My main research interest is the design and analysis of experiments, particularly the class of experiments that I have termed multitiered. I am also interested in the formulation of mixed models for the analysis of designed experiments, including  the analysis of longitudinal experiments. I originally graduated from the University of Sydney with an agricultural science degree majoring in Biometry. I started my professional life as a consulting Biometrician with what was then the CSIRO Division of Horticultural Research, designing and analyzing viticultural, sensory and other laboratory experiments. After 6 years with CSIRO I went to Roseworthy Agricultural College for a 10 year stint as a lecturer/consultant in statistics for agriculture, natural resources and oenology. During this time I completed a M.Ag.Sc. and began a PhD, both majoring in Biometry at the University of Adelaide. My last move was in 1988 to the Institute of Technology, one of the institutions that in 1991 became the University of South Australia. Here I was a Senior Lecturer in Statistics in the School of Mathematics and Statistics and I lectured/consulted in statistics in areas such as business, engineering, environmental sciences, library studies, physiotherapy and computer science. In February 2006 I, and my colleague Prof. Rosemary Bailey from The University of St Andrews, Scotland, presented a read paper entitled Multiple randomizations to the prestigious Royal Statistical Society in London.

I retired from the University of South Australia in November 2009, but I am continuing my research and consulting as an Adjunct Senior Lecturer in the Phenomics and Bioinformatics Research Centre and, since 2015, as  Senior Biometrician at the  Plant Accelerator in the School of Agriculture, Food and Wine at the University of Adelaide. In addition to continuing my work on multitiered experiments, I am currently working on the design and analysis of agricultural and other biological experiments. Particular areas of experimentation in which I work are in high-throughput, phenotyping experiments (see Brien et al. (2013) or Al-Tamimi et al. (2016)) and sugarcane breeding experiments. Click here for my Curriculum Vitae (in a pdf file).


Year Citation
2017 Campbell, M., Du, Q., Liu, K., Brien, C., Berger, B., Zhang, C. & Walia, H. (2017). A comprehensive image-based phenomic analysis reveals the complex genetic architecture of shoot growth dynamics in rice (Oryza sativa). Plant Genome, 10, 2, 1-14.
2017 Atieno, J., Li, Y., Langridge, P., Dowling, K., Brien, C., Berger, B. ... Sutton, T. (2017). Exploring genetic variation for salinity tolerance in chickpea using image-based phenotyping. Scientific Reports, 7, 1, -.
2017 Ferdous, J., Sanchez-Ferrero, J., Langridge, P., Milne, L., Chowdhury, J., Brien, C. & Tricker, P. (2017). Differential expression of microRNAs and potential targets under drought stress in barley. Plant, Cell & Environment, 40, 1, 11-24.
2017 Meng, R., Saade, S., Kurtek, S., Berger, B., Brien, C., Pillen, K. ... Sun, Y. (2017). Growth curve registration for evaluating salinity tolerance in barley. Plant Methods, 13, 1, 1-9.
2016 Bailey, R. & Brien, C. (2016). Randomization-based models for multitiered experiments: I. A chain of randomizations. Annals of Statistics, 44, 3, 1131-1164.
2016 Shirdelmoghanloo, H., Lohraseb, I., Rabie, H., Brien, C., Parent, B. & Collins, N. (2016). Heat susceptibility of grain filling in wheat (Triticum aestivum L.) linked with rapid chlorophyll loss during a 3-day heat treatment. Acta Physiologiae Plantarum, 38, 8, 208-1-208-11.
2016 Hardner, C., Evans, K., Brien, C., Bliss, F. & Peace, C. (2016). Genetic architecture of apple fruit quality traits following storage and implications for genetic improvement. Tree Genetics and Genomes, 12, 2, 1-21.
2016 Al-Tamimi, N., Brien, C., Oakey, H., Berger, B., Saade, S., Ho, Y. ... Negrão, S. (2016). Salinity tolerance loci revealed in rice using high-throughput non-invasive phenotyping. Nature Communications, 7, 13342-1-13342-11.
2016 Shirdelmoghanloo, H., Taylor, J., Lohraseb, I., Rabie, H., Brien, C., Timmins, A. ... Collins, N. (2016). A QTL on the short arm of wheat (Triticum aestivum L.) chromosome 3B affects the stability of grain weight in plants exposed to a brief heat shock early in grain filling. BMC Plant Biology, 16, 1, 100-1-100-15.
2016 Ferdous, J., Whitford, R., Nguyen, M., Brien, C., Langridge, P. & Tricker, P. (2016). Drought-inducible expression of Hv-miR827 enhances drought tolerance in transgenic barley. Functional and Integrative Genomics, Online, 2-3, 1-14.
2015 Campbell, M., Knecht, A., Berger, B., Brien, C., Wang, D. & Walia, H. (2015). Integrating image-based phenomics and association analysis to dissect the genetic architecture of temporal salinity responses in rice. Plant Physiology, 168, 4, 1476-1489.
2014 Razzaghmanesh, M., Beecham, S. & Brien, C. (2014). Developing resilient green roofs in a dry climate. Science of the Total Environment, 490, 579-589.
2013 Brien, C., Berger, B., Rabie, H. & Tester, M. (2013). Accounting for variation in designing greenhouse experiments with special reference to greenhouses containing plants on conveyor systems. Plant Methods, 9, 1, 1-22.
2013 Demétrio, C., Menten, J., Leandro, R. & Brien, C. (2013). Experimental power considerations-Justifying replication for animal care and use committees. Poultry Science, 92, 9, 2490-2497.
2012 Smith, G., Brien, C. & Ashman, H. (2012). Evaluating implicit judgments from image search clickthrough data. Journal of the American Society for Information Science and Technology, 63, 12, 2451-2462.
2012 Brien, C. J., Bailey, R. A., Tran, T. T. & Boland, J. (2012). Quasi-Latin designs. Electronic Journal of Statistics, 6, 1900-1925.
2012 Brien, C. (2012). Comments on 'Therapist variation within randomized trials of psychotherapy: Implications for precision, internal and external validity'. Statistical Methods in Medical Research, 21, 2, 215-216.
2011 Brien, C., Harch, B., Correll, R. & Bailey, R. (2011). Multiphase Experiments with at Least One Later Laboratory Phase. I. Orthogonal Designs. Journal of Agricultural, Biological, and Environmental Statistics, 16, 3, 422-450.
2010 Brito E Abreu, S., Brien, C. & Skinner, W. (2010). ToF-SIMS as a new method to determine the contact angle of mineral surfaces. Langmuir, 26, 11, 8122-8130.
2010 Brien, C. & Bailey, R. (2010). Decomposition tables for experiments. II. TWO-ONE randomizations. Annals of Statistics, 38, 5, 3164-3190.
2009 Brien, C. & Bailey, R. (2009). Decomposition tables for experiments I. A chain of randomizations. Annals of Statistics, 37, 6 B, 4184-4213.
2009 Brien, C. & Demétrio, C. (2009). Formulating mixed models for experiments, including longitudinal experiments. Journal of Agricultural, Biological, and Environmental Statistics, 14, 3, 253-280.
2008 Gross, M., Brien, C. & Brown, G. (2008). Examining the dimensions of a lifestyle tourism destination. International Journal of Culture, Tourism and Hospitality Research, 2, 1, 44-66.
2008 Wilkinson, R., Frisina, C., Partington, D., Franz, P., Brien, C., Thomson, F. ... Faragher, J. (2008). Effects of 1-methylcyclopropene on firmness and flesh browning in Pink Lady™ apples. Journal of Horticultural Science and Biotechnology, 83, 2, 165-170.
2006 Brien, C. & Bailey, R. (2006). Multiple randomizations. Journal of the Royal Statistical Society. Series B: Statistical Methodology, 68, 4, 571-609.
1999 Brien, C. & Payne, R. (1999). Tiers, structure formulae and the analysis of complicated experiments. Journal of the Royal Statistical Society Series D: The Statistician, 48, 1, 41-52.
1998 Brien, C. & Demétrio, C. (1998). Using the randomisation in specifying the ANOVA model and table for properly and improperly replicated grazing trials. Australian Journal of Experimental Agriculture, 38, 4, 325-334.
1996 Trott, P., Pearcy, M., Ruston, S., Fulton, I. & Brien, C. (1996). Three-dimensional analysis of active cervical motion: The effect of age and gender. Clinical Biomechanics, 11, 4, 201-206.
1996 David, G., Dvir, Z., Mackintosh, S. & Brien, C. (1996). Validity study of a novel test protocol for the identification of submaximal muscular effort. Isokinetics and Exercise Science, 6, 2, 139-144.
1995 Scutter, S., Fulton, I., Trott, P., Parnianpour, M., Grant, R. & Brien, C. (1995). Effects of various isoresistive training programmes on trunk muscle performance. Clinical Biomechanics, 10, 7, 379-384.
1988 Brien, C., James, A. & Venables, W. (1988). An analysis of correlation matrices: Variables cross-classified by two factors. Biometrika, 75, 3, 469-476.
1987 BRIEN, C., MAY, P. & MAYO, O. (1987). Analysis of Judge Performance in Wine‐Quality Evaluations. Journal of Food Science, 52, 5, 1273-1279.
1984 Brien, C., Venables, W., James, A. & Mayo, O. (1984). An analysis of correlation matrices: Equal correlations. Biometrika, 71, 3, 545-554.
1983 Brien, C. (1983). Analysis of variance tables based on experimental structure.. Biometrics, 39, 1, 53-59.
1978 May, P., Clingeleffer, P. & Brien, C. (1978). Pruning Sultana vines by the arched cane system. Australian Journal of Experimental Agriculture, 18, 91, 301-308.
1978 May, P., Clingelefer, P., Brien, C. & Scholejield, P. (1978). Harvest pruning of young sultana vines under various training systems. Australian Journal of Experimental Agriculture, 18, 95, 847-854.
Senior Biostatistician
8313 0828
Plant Accelerator Building
Room Number
1 35
Org Unit
School of Agriculture, Food and Wine