Dr Chris Brien

Chris Brien
Senior Biostatistician
School of Agriculture, Food and Wine
Faculty of Sciences

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Dr Chris Brien

Welcome to my profile. My main research interest is the design and analysis of experiments, particularly the class of experiments that I have termed multitiered. I am also interested in the formulation of mixed models for the analysis of designed experiments, including  the analysis of longitudinal experiments. I originally graduated from the University of Sydney with an agricultural science degree majoring in Biometry. I started my professional life as a consulting Biometrician with what was then the CSIRO Division of Horticultural Research, designing and analyzing viticultural, sensory and other laboratory experiments. After 6 years with CSIRO I went to Roseworthy Agricultural College for a 10 year stint as a lecturer/consultant in statistics for agriculture, natural resources and oenology. During this time I completed a M.Ag.Sc. and began a PhD, both majoring in Biometry at the University of Adelaide. My last move was in 1988 to the Institute of Technology, one of the institutions that in 1991 became the University of South Australia. Here I was a Senior Lecturer in Statistics in the School of Mathematics and Statistics and I lectured/consulted in statistics in areas such as business, engineering, environmental sciences, library studies, physiotherapy and computer science. In February 2006 I, and my colleague Prof. Rosemary Bailey from The University of St Andrews, Scotland, presented a read paper entitled Multiple randomizations to the prestigious Royal Statistical Society in London.

I retired from the University of South Australia in November 2009, but I am continuing my research and consulting as an Adjunct Senior Lecturer in the Phenomics and Bioinformatics Research Centre and, since 2015, as  Senior Biometrician at the  Plant Accelerator in the School of Agriculture, Food and Wine at the University of Adelaide. In addition to continuing my work on multitiered experiments, I am currently working on the design and analysis of agricultural and other biological experiments. Particular areas of experimentation in which I work are in high-throughput, phenotyping experiments (see Brien et al. (2013) or Al-Tamimi et al. (2016)) and sugarcane breeding experiments. Click here for my Curriculum Vitae (in a pdf file).


Year Citation
2017 Ferdous, J., Whitford, R., Nguyen, M., Brien, C., Langridge, P., & Tricker, P. (2017). Drought-inducible expression of Hv-miR827 enhances drought tolerance in transgenic barley. Functional and Integrative Genomics, 17(2-3), 279-292.
DOI Scopus3 WoS4 Europe PMC2
2017 Ferdous, J., Sanchez-Ferrero, J., Langridge, P., Milne, L., Chowdhury, J., Brien, C., & Tricker, P. (2017). Differential expression of microRNAs and potential targets under drought stress in barley. Plant, Cell & Environment, 40(1), 11-24.
DOI Scopus6 WoS9 Europe PMC5
2017 Meng, R., Saade, S., Kurtek, S., Berger, B., Brien, C., Pillen, K., . . . Sun, Y. (2017). Growth curve registration for evaluating salinity tolerance in barley. Plant Methods, 13(1), 1-9.
2017 Atieno, J., Li, Y., Langridge, P., Dowling, K., Brien, C., Berger, B., . . . Sutton, T. (2017). Exploring genetic variation for salinity tolerance in chickpea using image-based phenotyping. Scientific Reports, 7(1), 11 pages.
2017 Campbell, M., Du, Q., Liu, K., Brien, C., Berger, B., Zhang, C., & Walia, H. (2017). A comprehensive image-based phenomic analysis reveals the complex genetic architecture of shoot growth dynamics in rice (Oryza sativa). Plant Genome, 10(2), 1-14.
2017 Tilbrook, J., Schilling, R., Berger, B., Garcia, A., Trittermann, C., Coventry, S., . . . Roy, S. (2017). Variation in shoot tolerance mechanisms not related to ion toxicity in barley. Functional Plant Biology, 44(12), 1194-1206.
2017 Brien, C. (2017). Multiphase experiments in practice: A look back. Australian and New Zealand Journal of Statistics, 59(4), 327-352.
2016 Shirdelmoghanloo, H., Taylor, J., Lohraseb, I., Rabie, H., Brien, C., Timmins, A., . . . Collins, N. (2016). A QTL on the short arm of wheat (Triticum aestivum L.) chromosome 3B affects the stability of grain weight in plants exposed to a brief heat shock early in grain filling. BMC Plant Biology, 16(1), 100-1-100-15.
DOI Scopus4 WoS4 Europe PMC1
2016 Hardner, C., Evans, K., Brien, C., Bliss, F., & Peace, C. (2016). Genetic architecture of apple fruit quality traits following storage and implications for genetic improvement. Tree Genetics and Genomes, 12(2), 20-1-20-21.
DOI Scopus3
2016 Bailey, R., & Brien, C. (2016). Randomization-based models for multitiered experiments: I. A chain of randomizations. Annals of Statistics, 44(3), 1131-1164.
DOI Scopus3 WoS2
2016 Shirdelmoghanloo, H., Lohraseb, I., Rabie, H., Brien, C., Parent, B., & Collins, N. (2016). Heat susceptibility of grain filling in wheat (Triticum aestivum L.) linked with rapid chlorophyll loss during a 3-day heat treatment. Acta Physiologiae Plantarum, 38(8), 208-1-208-11.
2016 Al-Tamimi, N., Brien, C., Oakey, H., Berger, B., Saade, S., Ho, Y., . . . Negrão, S. (2016). Salinity tolerance loci revealed in rice using high-throughput non-invasive phenotyping. Nature Communications, 7, 13342-1-13342-11.
DOI Scopus10 WoS11 Europe PMC9
2015 Campbell, M., Knecht, A., Berger, B., Brien, C., Wang, D., & Walia, H. (2015). Integrating image-based phenomics and association analysis to dissect the genetic architecture of temporal salinity responses in rice. Plant Physiology, 168(4), 1476-1489.
DOI Scopus24 WoS25 Europe PMC12
2014 Razzaghmanesh, M., Beecham, S., & Brien, C. (2014). Developing resilient green roofs in a dry climate. Science of the Total Environment, 490, 579-589.
DOI Scopus13 WoS11 Europe PMC2
2013 Demétrio, C., Menten, J., Leandro, R., & Brien, C. (2013). Experimental power considerations-Justifying replication for animal care and use committees. Poultry Science, 92(9), 2490-2497.
DOI Scopus2 Europe PMC1
2013 Brien, C., Berger, B., Rabie, H., & Tester, M. (2013). Accounting for variation in designing greenhouse experiments with special reference to greenhouses containing plants on conveyor systems. Plant Methods, 9(1), 1-22.
DOI Scopus16 WoS15 Europe PMC9
2012 Smith, G., Brien, C., & Ashman, H. (2012). Evaluating implicit judgments from image search clickthrough data. Journal of the American Society for Information Science and Technology, 63(12), 2451-2462.
DOI Scopus12
2012 Brien, C. (2012). Comments on 'Therapist variation within randomized trials of psychotherapy: Implications for precision, internal and external validity'. Statistical Methods in Medical Research, 21(2), 215-216.
DOI Scopus1
2012 Brien, C. J., Bailey, R. A., Tran, T. T., & Boland, J. (2012). Quasi-Latin designs. Electronic Journal of Statistics, 6(0), 1900-1925.
2011 Brien, C., Harch, B., Correll, R., & Bailey, R. (2011). Multiphase Experiments with at Least One Later Laboratory Phase. I. Orthogonal Designs. Journal of Agricultural, Biological, and Environmental Statistics, 16(3), 422-450.
DOI Scopus14
2010 Brien, C., & Bailey, R. (2010). Decomposition tables for experiments. II. TWO-ONE randomizations. Annals of Statistics, 38(5), 3164-3190.
DOI Scopus6
2010 Brito E Abreu, S., Brien, C., & Skinner, W. (2010). ToF-SIMS as a new method to determine the contact angle of mineral surfaces. Langmuir, 26(11), 8122-8130.
DOI Scopus21
2009 Brien, C., & Bailey, R. (2009). Decomposition tables for experiments I. A chain of randomizations. Annals of Statistics, 37(6 B), 4184-4213.
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2009 Brien, C., & Demétrio, C. (2009). Formulating mixed models for experiments, including longitudinal experiments. Journal of Agricultural, Biological, and Environmental Statistics, 14(3), 253-280.
DOI Scopus17
2008 Gross, M., Brien, C., & Brown, G. (2008). Examining the dimensions of a lifestyle tourism destination. International Journal of Culture, Tourism and Hospitality Research, 2(1), 44-66.
DOI Scopus20
2008 Wilkinson, R., Frisina, C., Partington, D., Franz, P., Brien, C., Thomson, F., . . . Faragher, J. (2008). Effects of 1-methylcyclopropene on firmness and flesh browning in Pink Lady™ apples. Journal of Horticultural Science and Biotechnology, 83(2), 165-170.
DOI Scopus5
2006 Brien, C., & Bailey, R. (2006). Multiple randomizations. Journal of the Royal Statistical Society. Series B: Statistical Methodology, 68(4), 571-609.
DOI Scopus38
1999 Brien, C., & Payne, R. (1999). Tiers, structure formulae and the analysis of complicated experiments. Journal of the Royal Statistical Society Series D: The Statistician, 48(1), 41-52.
DOI Scopus12
1998 Brien, C., & Demétrio, C. (1998). Using the randomisation in specifying the ANOVA model and table for properly and improperly replicated grazing trials. Australian Journal of Experimental Agriculture, 38(4), 325-334.
1996 David, G., Dvir, Z., Mackintosh, S., & Brien, C. (1996). Validity study of a novel test protocol for the identification of submaximal muscular effort. Isokinetics and Exercise Science, 6(2), 139-144.
1996 Trott, P., Pearcy, M., Ruston, S., Fulton, I., & Brien, C. (1996). Three-dimensional analysis of active cervical motion: The effect of age and gender. Clinical Biomechanics, 11(4), 201-206.
DOI Scopus104
1995 Scutter, S., Fulton, I., Trott, P., Parnianpour, M., Grant, R., & Brien, C. (1995). Effects of various isoresistive training programmes on trunk muscle performance. Clinical Biomechanics, 10(7), 379-384.
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1988 Brien, C., James, A., & Venables, W. (1988). An analysis of correlation matrices: Variables cross-classified by two factors. Biometrika, 75(3), 469-476.
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1987 BRIEN, C., MAY, P., & MAYO, O. (1987). Analysis of Judge Performance in Wine‐Quality Evaluations. Journal of Food Science, 52(5), 1273-1279.
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1984 Brien, C., Venables, W., James, A., & Mayo, O. (1984). An analysis of correlation matrices: Equal correlations. Biometrika, 71(3), 545-554.
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1983 Brien, C. (1983). Analysis of variance tables based on experimental structure.. Biometrics, 39(1), 53-59.
DOI Scopus23 Europe PMC4
1978 May, P., Clingelefer, P., Brien, C., & Scholejield, P. (1978). Harvest pruning of young sultana vines under various training systems. Australian Journal of Experimental Agriculture, 18(95), 847-854.
DOI Scopus3
1978 May, P., Clingeleffer, P., & Brien, C. (1978). Pruning Sultana vines by the arched cane system. Australian Journal of Experimental Agriculture, 18(91), 301-308.
DOI Scopus2
Senior Biostatistician
8313 0828
Plant Accelerator Building, floor 1
Room Number
1 35
Org Unit
School of Agriculture, Food and Wine