Senior Research Officer
Adelaide Medical School
Faculty of Health and Medical Sciences
My Research :
Dr Chandra Kirana's research interest focus on finding biomarkers for bowel cancer patients using proteomic approaches. Almost 90% of bowel cancer patients died from metastatic dissemination mostly to the liver. Protein biomarkers are urgently required to support current methodologies to improve accuracy in stratifying patients into low and high risk of metastasis so that accurate disease management will be given to the patients to increase survival. In addition, she is also interested in using the concept of "seed and soil" to understand the mechanism of metastatic dissemination of colorectal cancer to the liver. Her work equipped with a large number of samples from bowel cancer patients completed with clinical parameters of the patients and the histology of tumours. She also has experience in isolation and identification of bio-active compounds from medicinal plants using various chromatographic and spectrophotometric techniques. Her previous work involved using small animals to assess efficacy of active compounds isolated from medicinal plants including AOM-induced colon cancer and DSS-induced inflammatory bowel disease model study.
Clinicians at The Queen Elizabeth Hospital and Royal Adelaide Hospital
Mr John Keating, Wellington Hospital, Wellington, New Zealand
Professor Richard Stubbs, P3 Research, Wellington, New Zealand
Dr Lifeng Peng, Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
Dr Andrea Bubendorfer, Callaghan Innovation, New Zealand's Innovation Agency, Wellington, New Zealand
Cancer Voices SA
Date Position Institution name 2018 - ongoing Senior Research Officer University of Adelaide 2014 - 2018 Research Officer University of Adelaide, Adelaide 2007 - 2018 Postdoctoral Fellow Wakefield Biomedical Research Institute 2003 - 2006 Postdoctoral Fellow Diet & nutrition (CSIRO), Adelaide 1989 - 1999 Lecturer Brawijaya University
Language Competency English Can peer review Indonesian Can peer review
Date Institution name Country Title 1999 - 2003 University of Adelaide, Adelaide Australia PhD 1993 - 1996 University of Adelaide, Adelaide Australia MAgSc — Gadjah Mada University Indonesia Bsc (Hons) (Biology)
Year Citation 2020 Kirana, C., Smith, E., Ngo, D. T., Trochsler, M. I., Hewett, P. J., Stubbs, R. S., . . . Hauben, E. (2020). High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients.. Future Oncol, 16(31), 2499-2509.
2019 Kirana, C., Peng, L., Miller, R., Keating, J. P., Glenn, C., Shi, H., . . . Stubbs, R. S. (2019). Combination of laser microdissection, 2D-DIGE and MALDI-TOF MS to identify protein biomarkers to predict colorectal cancer spread. Clinical Proteomics, 16(1), 13 pages.
DOI Scopus12 WoS12 Europe PMC8
2017 Kirana, C., Ruszkiewicz, A., Stubbs, R., Hardingham, J., Hewett, P., Maddern, G., & Hauben, E. (2017). Soluble HLA-G is a differential prognostic marker in sequential colorectal cancer disease stages. International Journal of Cancer, 140(11), 2577-2586.
DOI Scopus24 WoS19 Europe PMC10
2017 Miljkovic, D., Ou, J., Kirana, C., Hulse, K., Hauben, E., Psaltis, A., . . . Vreugde, S. (2017). Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 7(6), 609-614.
DOI Scopus4 WoS4 Europe PMC1
2013 Shi, H., Hayes, M., Kirana, C., Miller, R., Keating, J., & Stubbs, R. (2013). Overexpression of aminoacylase 1 is associated with colorectal cancer progression. Human Pathology, 44(6), 1089-1097.
DOI Scopus13 WoS13 Europe PMC12
2012 Kirana, C., Shi, H., Laing, E., Hood, K., Miller, R., Bethwaite, P., . . . Stubbs, R. (2012). Cathepsin D expression in colorectal cancer: from proteomic discovery through validation using western blotting, immunohistochemistry, and tissue microarrays. International journal of proteomics, 2012, 1-11.
DOI Europe PMC14
2012 Shi, H., Hayes, M., Kirana, C., Miller, R., Keating, J., MacArtney-Coxson, D., & Stubbs, R. (2012). TUFM is a potential new prognostic indicator for colorectal carcinoma. Pathology, 44(6), 506-512.
DOI Scopus25 WoS23 Europe PMC17
2009 Kirana, C., Ward, T., Jordan, T. W., Rawson, P., Royds, J., Shi, H. J., . . . Hood, K. (2009). Compatibility of toluidine blue with laser microdissection and saturation labeling DIGE. Proteomics, 9(2), 485-490.
DOI Scopus13 WoS12 Europe PMC11
2007 Kirana, C., Jones, G., Record, I., & McIntosh, G. (2007). Anticancer properties of panduratin A isolated from Boesenbergia pandurata (Zingiberaceae). Journal of Natural Medicines, 61(2), 131-137.
DOI Scopus52 WoS39
2005 Kirana, C., Rogers, P. F., Bennett, L. E., Abeywardena, M. Y., & Patten, G. S. (2005). Naturally derived micelles for rapid in vitro screening of potential cholesterol-lowering bioactives. Journal of Agricultural and Food Chemistry, 53(11), 4623-4627.
DOI Scopus49 WoS40 Europe PMC28
2003 Kirana, C., McIntosh, G., Record, I., & Jones, G. (2003). Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutrition and Cancer-An International Journal, 45(2), 218-225.
DOI Scopus100 WoS83 Europe PMC53
2003 Kirana, C., Record, I., McIntosh, G., & Jones, G. (2003). Screening for antitumor activity of 11 species of Indonesian Zingiberaceae using human MCF-7 and HT-29 cancer cells. Pharmaceutical Biology, 41(4), 271-276.
DOI Scopus46 WoS30
Year Citation 2019 Sulaiman, R., Isnanto, B., Ki, H., & Kirana, C. (2019). Cryptography in (LSB) method using rc4 algorithm and aes algorithm in digital image to improve message security. In Proceedings - 2018 4th International Conference on Computing, Engineering, and Design, ICCED 2018 (pp. 29-34). online: IEEE.
2018 Kirana, C. (2018). Communication between mothers and children about environmental issues (a study about the role of mothers to educate their children on keeping a clean environment). In E3S Web of Conferences Vol. 74 (pp. 1-7). online: EDP Sciences.
2005 Kirana, C., Rogers, P., Bennett, L., Abeywardena, M., & Patten, G. (2005). Rapid screening for potential cholesterol-lowering peptides using naturally derived micelle preparation. In Australian Journal of Dairy Technology Vol. 60 (pp. 163-166). Adelaide, AUSTRALIA: DAIRY INDUSTRY ASSOC AUSTRALIA.
Date Role Committee Institution Country 2017 - ongoing Member TQEH Strategic Research Direction The Queen Elizabeth Hospital - Basil Hetzel Research Institute Australia 2016 - ongoing Member The Institute (BHI) Policy Committee Basil Hetzel Institute Australia 2015 - ongoing Co-Chair The Institute (Basil Hetzel Institute) Management Committee Basil Hetzel Research Institute Australia
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