NHMRC Peter Doherty Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Lang holds an Early Career Postdoctoral Research Fellowship from the National Health and Medical Research Council of Australia (NHMRC). Carol has previously undertaken laboratory based research into the composition and function of pulmonary surfactant and has studied the role of the dietary metal zinc, and the proteins that transport zinc, in allergic, viral and smoke-induced airway inflammation and respiratory disease. In 2014, Carol joined The Health Observatory at the Basil Hetzel Institute for Translational Health Research and University of Adelaide to undertake training in epidemiology and to study sleep disordered breathing. Her latest research has focused on the two most common sleep disorders known as obstructive sleep apnea and insomnia. Carol is currently using epidemiological research techniques to study how these sleep disorders relate to cognition and mental health as we age.
The Health Observatory
The mission of The Health Observatory is to conduct innovative population and clinical research studies and produce the evidence for initiatives that promote prevention, lead to early detection and better management of disease, and improve quality of life, well-being and mental health. Observatory research also investigates the interaction of health services with patients to identify opportunities that lead to more effective health care and management, and that will maximise health outcomes. We have research opportunities available to anyone interested in clinical, epidemiological or population research, as well as health services research, health economics or mathematical modelling.
Sleep Disorders and Mental Health
Obstructive sleep apnea (OSA) and insomnia are common sleep disorders that can frequently coexist in patients. OSA is characterised by recurrent episodes of complete (apnea) and partial (hypopnea) closure of the upper airway during sleep whilst insomnia is characterised by subjective problems falling or staying asleep resulting in a loss of vitality, or fatigue during the day. Both these sleep disorders have a high rate of under-diagnosis in the community and are known to be associated with adverse outcomes i.e. heart disease, diabetes, kidney disease, mental health, accidents and quality of life.
My current work aims to explore the relationships between sleep, cognition and mood disorders across the adult lifespan in men. Australia, like many countries faces an aging population and as such age-related deterioration in cognition and mental health represent significant economic and quality of life burdens to society. Our work has shown that in men, previously undiagnosed obstructive sleep apnea is associated with depressive symptoms. Moreover, men with both obstructive sleep apnea and insomnia have a greater prevalence, and severity, of depression than men with only one of these sleep disorders. As a result, we have suggested that clinicians managing either sleep disorders or depression incorporate screening methods to ensure that a patient presenting with one disorder is assessed for the other. However, it is evident that innovative screening tools are urgently needed in order to (a) better identify and classify sleep disorders (both in sleep clinics and the wider community) and (b) identify those at risk of cognitive dysfunction and/or mood disorders. This is essential in order that the appropriate treatment strategies can be put in place for individuals. My work aims to address current gaps in the research of sleep, cognition and mood disorders as we age. One of the limitations of previous studies investigating sleep patterns in ageing and cognition in particular is that most have failed to assess and therefore adjust for pre-existing sleep and mood disorders. There have been very few community based population studies in this area and even fewer longitudinal population studies to ascertain causality.
We have completed overnight sleep studies on 837 community-dwelling men in the MAILES Study in 2010-11, and are following their progress. The MAILES Study is a biomedical prospectively followed population cohort study of N = 2569 community-dwelling men from metropolitan Adelaide. Initial recruitment was by random selection via computer assisted telephone interviews (CATI) in 1999-2003. Follow-ups have occurred in 2007-10 (Stage 2, N = 2038), 2010 (Stage 3 CATI, N = 1629), 2010-11 (Sleep Study, N = 837) and 2016 (Stage 5, recently completed). A follow-up in 2017-19 is already planned and funded by the NHMRC. This is the first longitudinal population based study in Australia since the advent of more sensitive sleep study methods and one of very few worldwide to examine health outcomes associated with sleep disorders.
Current projects from this data, of which my work is a part, include investigation of:
- the independent effects of OSA and insomnia over the follow up period on a composite of clinical health outcomes; quality of life, and health and societal costs, including accidents and work force participation. The aim is to determine a threshold of OSA severity at which overall health becomes compromised and health care and societal costs rise.
- new markers of OSA on sleep studies (power spectral analysis, heart rate variability) can be used to improve the precision for identifying those at risk of adverse consequences
- the influence of sleep quality and insomnia on health outcomes
- health economics analyses, including cost per DALY/QALY and decision analytic simulation studies for treatments
Examples of media articles
Prior Research in Respiratory Medicine
My previous research was laboratory based and included studying healthy and diseased airways [asthma and smoking disorders], airway inflammation, hypoxia and the pulmonary surfactant system using a range of laboratory, biochemical, cell and molecular techniques. Although I am currently focusing on sleep disordered breathing from an epidemiological perspective (described above), please be aware that I do still hold an active interest in airway research and remain open to the possibility of joining collaborative research teams, new research projects and/or supervising students in respiratory medicine. Some of my key research projects have included:
Chronic Inflammation in Disease: I was a chief investigator on a large collaborative program grant from The Hospital Research Foundation that aimed to investigate common mechanisms of chronic inflammation. I led one of the key projects funded by this grant which looked at inflammasome activation in laboratory models of asthma. Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is normally tightly regulated by the body. Dysregulated or prolonged (chronic) inflammation underpins the chronic diseases that are prominent in our community i.e. Asthma and Chronic Obstructive Pulmonary Disease (COPD), Chronic Rhinosinusitis, Rheumatological diseases and Stroke. Independent of these chronic diseases prolonged inflammation reduces health and longevity and is associated with aging. The persistence of chronic inflammation is in large part due to over-production or inappropriate production of one or more pro-inflammatory cytokines that drive the mobilisation of inflammatory cells to the sites of tissue injury and inflammation, as well as activation of these inflammatory cells to release proteases, oxyradicals and other agents which cause further damage. Proinflammatory cytokines are produced by immune and inflammatory cells at the site of tissue damage as well as by the damaged epithelium, fibroblasts and neighbouring cells. Pattern recognition receptors (PRRs), which include toll-like receptors (TLRs) and Nod-like receptors (NLRs), are key components of the innate immune system. These PRRs have evolved as intracellular sensors to detect cytosolic microbial components and extracellular “danger” signals such as ATP and toxins. The caspase-1 (NALP3) inflammasome is part of the NLR family, and we proposed that dysregulation or perpetual activation of the inflammasome would play a critical role in driving the process of chronic inflammation. We developed a range of molecular tools targeting the inflammasome pathway (RNAi, antibodies, caspase inhibitors, P2X7 receptor agonist/antagonists) which provided an opportunity to further dissect the mechanisms of disease and identify new therapeutic approaches.
Location: Basil Hetzel Institute for Translational Health Research and The Queen Elizabeth Hospital, Woodville, South Australia.
The role of zinc, and proteins that transport zinc, in the airways and in airway inflammation: My work focused on the links between the dietary metal zinc and asthma and chronic obstructive pulmonary disease. Human asthma is associated with low zinc status and the cells lining healthy airways contain large pools of free zinc. We conducted the first complete study of two newly discovered families of proteins that transport zinc in airway cells (known as zinc transporters) and investigated how the gene and protein expression of these proteins were affected by (1) allergic inflammation, as occurs in asthma; (2) cigarette smoke, which is a major cause of chronic obstructive pulmonary disease, and (3) common respiratory viruses.
Fellowship Supervisors: Dr Peter Zalewski, Prof Richard Ruffin
Location: Basil Hetzel Institute for Translational Health Research and Department of Medicine, The University of Adelaide
Acute Lung Injury and Cell Stretch: Acute Lung Injury is an inflammatory condition that arises from lung insults (eg pneumonia; sepsis) and often requires mechanical ventilation. Alveolar macrophages & alveolar type II epithelial cells release inflammatory mediators in response to bacterial lipopolysaccharide to initiate lung inflammation. High volume ventilation, or cell stretch can worsen lung injury. Ventilatory treatment strategies can favour low tidal volumes & high end-expiratory volumes to reduce lung stretch & ‘rest’ the lung. “Protective” ventilatory strategies may give rise to hypercapnic acidosis (low pH due to high carbon dioxide. Our work utilised cell culture techniques and defined the specific responses of lung cells to carbon dioxide, stretch and pH.
Supervisor: Ian Doyle
Location: Department of Human Physiology, Flinders University of South Australia, Bedford Park, South Australia.
Pulmonary Surfactant (PhD research): Pulmonary surfactant is a mixture of lipids and proteins that is crucial for lung function. Due to the biophysical properties of lipids, temperature potentially can have a profound effect on surfactant function. Heterothermic mammals regularly endure changes in body temperature without suffering from surfactant dysfunction. Surfactant is synthesised in alveolar type II epithelial cells & secreted in response to the autonomic nervous system & other regulatory factors. I investigated the thermal dynamics of the surfactant systems in homeothermic & heterothermic mammals, at cellular, compositional, biophysical & functional levels. Although, the value of comparative research is still often undervalued by biomedical scientists my PhD research challenged basic paradigms of surfactant function and impacted the design of therapeutic surfactants in humans (personal communication from colleagues).
Key Collaborators: Prof Emiritus William Milsom (University of British Columbia, Canada), Prof Anthony Postle (University of Southampton, UK), Prof Fred Possmayer (Children's Health Research Institute, Canada).
Location: Department of Environmental Biology, University of Adelaide.
Research Funding Acknowledgements
Research Organisations that have supported my research, and research career include:
Australian Lung Foundation/Boehringer Ingelheim;
Boehringer Ingelheim Fonds;
Society of Experimental Biology;
American Thoracic Society;
Thoracic Society of Australia and New Zealand.
Date Position Institution name 2011 - 2014 Playgroup Coordinator Uniting Church of South Australia 2006 - 2017 NHMRC Research Fellow (Australian Biomedical Postdoctoral Training Fellowship) University of Adelaide 2005 - 2006 Australian Lung Foundation/Boehringer Ingelheim Chronic Airflow Limitation Research Fellow University of Adelaide 2004 - 2005 NHMRC Post-doctoral Research Officer University of Adelaide 2004 - 2004 NHMRC Research Associate Flinders University of South Australia 2000 - 2003 Practical Demonstrator University of Adelaide 1994 - 1998 Research Assistant Child Health Research Institute
Awards and Achievements
Date Type Title Institution Name Amount 2015 Honour NHMRC Outstanding External Assessor National Health and Medical Research Council of Australia 2015 Award American Thoracic Society Assembly on Sleep and Respiratory Neurobiology Abstract Scholarship American Thoracic Society Assembly on Sleep and Respiratory Neurobiology $500 US 2015 - 2015 Research Award University of Adelaide Discipline of Medicine Travel Grant 2015 American Thoracic Society $5000.00 2015 Scholarship Sleep and Breathing Abstract Bursary 2010 - 2010 Scholarship Thoracic Society of Australia and New Zealand Janet Elder Travel Award Thoracic Society of Australia and New Zealand 2006 - 2006 Scholarship Asia Pacific Society of Respirology Career Development Award Asian Pacific Society of Respirology 2006 Scholarship Qantas Researcher Travel Support Grant 2005 - 2008 Recognition University of Melbourne Visiting Academic Status 2004 Invitation 'Thanking Address' at University of Adelaide Science Graduation Ceremony University of Adelaide 2003 Award Society of Experimental Biology Travel Grant £250 2001 - 2003 Scholarship University of Adelaide Research Abroad Scholarship $1000 2001 - 2003 Scholarship Australian Federation of University Women Jean Gilmore Bursary $6000 2001 - 2003 Scholarship Boehringer Ingelheim Fonds Travel Scholarship 6000DM 2001 - 2001 Scholarship Society of Experimental Biology Travel Grant £500 2001 - 2001 Scholarship University of Adelaide DR Stranks Postgraduate Travelling Fellowship $1500
Language Competency English Can read, write, speak, understand spoken and peer review
Date Institution name Country Title 2000 - 2004 University of Adelaide Australia PhD: Bioscience 1999 - 1999 University of Adelaide Australia Honours 1993 - 1998 University of Adelaide Australia Bachelor of Science
Date Title Institution name Country 2009 Advanced Course in Research Statistics Thoracic Society of Australia and New Zealand Australia 2006 Micromon Recombinant DNA Techniques Course Monash University 2005 Supervising Postgraduate Research Students Workshop University of Adelaide, Adelaide Australia 2005 Short course for Respiratory Research Thoracic Society of Australia and New Zealand 2005 University Teaching for Effective Student Learning Course (part of the Graduate Certificate in Higher Education) University of Adelaide, Adelaide Australia 2004 Introduction to SPSS II (Statistical Analysis) Course Flinders University of South Australia
Year Citation 2017 Lang, C., Appleton, S., Vakulin, A., McEvoy, R., Vincent, A., Wittert, G. ... Adams, R. (2017). Associations of undiagnosed obstructive sleep apnea and excessive daytime sleepiness with depression: An Australian population study. Journal of Clinical Sleep Medicine, 13, 4, 575-582.
2017 Adams, R., Appleton, S., Taylor, A., Gill, T., Lang, C., McEvoy, R. & Antic, N. (2017). Sleep health of Australian adults in 2016: results of the 2016 Sleep Health Foundation national survey. Sleep Health, 3, 1, 35-42.
2017 Adams, R., Appleton, S., Vakulin, A., Hanly, P., McDonald, S., Martin, S. ... others, (2017). Kidney disease and sleep apnea association of kidney disease with obstructive sleep apnea in a population study of men. Sleep, 40, 1, zsw015-1-zsw015-9.
2017 Lang, C., Appleton, S., Vakulin, A., McEvoy, R., Wittert, G., Martin, S. ... Adams, R. (2017). Co-morbid OSA and insomnia increases depression prevalence and severity in men. Respirology, 22, 7, 1407-1415.
2016 Appleton, S. L., Vakulin, A., Martin, S. A., Lang, C. J., Wittert, G. A., Taylor, A. W. ... Adams, R. J. (2016). Hypertension Is associated With undiagnosed OSA during rapid eye movement sleep. Chest, 150, 3, 495-505.
2016 Appleton, S. L. & Adams, R. J. (2016). The association of daytime sleepiness with obstructive sleep apnea and comorbidities varies by sleepiness definition in a population cohort of men.. Respirology, 21, 7, 1314-1321.
2016 Adams, R., Appleton, S., Vakulin, A., Hanly, P., McDonald, S., Martin, S. ... others, (2016). Association of kidney disease with obstructive sleep apnea in a population study of men.. Chest, 495-505. 2014 Hamon, R., Homan, C., Tran, H., Mukaro, V., Lester, S., Roscioli, E. ... Hodge, S. (2014). Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD. PLoS ONE, 9, 10, e110056-1-e110056-9.
2012 Tran, H., Lewis, M., Tan, L., Lester, S., Baker, L., Ng, J. ... Lang, C. (2012). Immunolocalization of NLRP3 inflammasome in normal murine airway epithelium and changes following induction of ovalbumin-induced airway inflammation. Journal of Allergy, Online, 819176, 1-13.
2011 Bosco, M., Mohanasundaram, D., Drogemuller, C., Lang, C., Zalewski, P. & Coates, P. (2011). Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. The Review of Diabetic Studies, 7, 4, 263-274.
2011 Lang, C., Hansen, M., Roscioli, E., Jones, J., Murgia, C., Ackland, M. ... Ruffin, R. (2011). Dietary zinc mediates inflammation and protects against wasting and metabolic derangement caused by sustained cigarette smoke exposure in mice. Biometals, 24, 1, 23-39.
2011 Tran, H., Rischmueller, M., Lester, S., Tan, L., Lewis, M., Koblar, S. ... Zalewski, P. (2011). INFLAMMASOME ACTIVATION IS IMPLICATED IN DISEASE PATHOGENESIS IN ASTHMA AND PRIMARY SJOGREN'S SYNDROME. INTERNAL MEDICINE JOURNAL, 41, 9-9. 2011 Mohanasundaram, D., Drogemuller, C., Brealey, J., Jessup, C., Milner, C., Murgia, C. ... Coates, P. (2011). Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets. General and Comparative Endocrinology, 174, 2, 71-79.
2011 Murgia, C., Grosser, D., TruongTran, A., Roscioli, E., Michalczyk, A., Ackland, M. ... Zalewski, P. (2011). Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation. Nutrients, 3, 11, 910-928.
2007 Lang, C., Murgia, C., Leong, M., Tan, L., Perozzi, G., Knight, D. ... Zalewski, P. (2007). Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology, 292, 2, L577-L584.
2007 Orgeig, S., Bernhard, W., Biswas, S., Daniels, C., Hall, S., Hetz, S. ... Yan, W. (2007). The anatomy physics and physiology of gas exchange surfaces: is there a universal function for pulmonary surfactant in animal respiratory structures?. Integrative and Comparative Biology, 47, 4, 610-627.
2006 Murgia, C., Lang, C., TruongTran, A., Grosser, D., Jayaram, L., Ruffin, R. ... Zalewski, P. (2006). Zinc and its specific transporters as potential targets in airway disease. Current Drug Targets, 7, 5, 607-627.
2006 Lang, C., Barnett, E. & Doyle, I. (2006). Stretch and CO2 modulate the inflammatory response of alveolar macrophages through independent changes in metabolic activity. Cytokine, 33, 6, 346-351.
2006 Zalewski, P., TruongTran, A., Lincoln, S., Ward, A., Shankar, A., Coyle, P. ... Ruffin, R. (2006). Use of a zinc fluorophore to measure labile pools of zinc in body fluids and cell-conditioned media. Biotechniques, 40, 4, 509-520.
2005 Lang, C., Postle, A., Orgeig, S., Possmayer, F., Bernhard, W., Panda, A. ... Daniels, C. (2005). Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 289, 5, R1426-R1439.
2005 Lang, C., Dong, P., Hosszu, E. & Doyle, I. (2005). Effect of CO2 on LPS-induced cytokine responses in rat alveolar macrophages. American Journal of Physiology-Lung Cellular and Molecular Physiology, 289, 1 33-1, L96-L103.
2003 Lang, C., Orgeig, S. & Daniels, C. (2003). The effect of temperature on adrenergic receptors of alveolar type II cells of a heterothermic marsupial. Biochemical and Biophysical Research Communications, 310, 3, 703-709.
2003 Lang, C., Orgeig, S., Daniels, C. & Milsom, W. (2003). Thermal acclimation of surfactant secretion and its regulation by adrenergic and cholinergic agonists in type II cells isolated from warm-active and torpid golden-mantled ground squirrels, Spermophilus lateralis. Journal of Experimental Biology, 206, 17, 3031-3041.
2001 Lang, C., Daniels, C. & Orgeig, S. (2001). Neurochemical and thermal control of surfactant secretion by alveolar type II cells isolated from the marsupial, Sminthopsis crassicaudata. Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology, 171, 3, 223-230.
Year Citation 2005 Lang, C., Daniels, C. & Orgeig, S. (2005). New insights into the thermal dynamics of the surfactant system from warm and cold animals. In K. Nag (Ed.), Lung Surfactant Function and Disorder (pp. 17-57). 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: Taylor & Francis.
Year Citation 2015 Lang, C., Appleton, S., Vakulin, A., Mevoy, D., Wittert, G., Martin, S. ... Adams, R. (2015). Obstructive Sleep Apnea (osa) And Excessive Daytime Sleepiness (eds) Are Independently Associated With Depression In A Community Based Population Of Australian Men. International Conference of the American-Thoracic-Society (ATS). Denver, CO. 2015 Lang, C., Appleton, S., Vakulin, A., Mcevoy, D., Wittert, G., Martin, S. ... Adams, R. (2015). OBSTRUCTIVE SLEEP APNEA (OSA) AND EXCESSIVE DAYTIME SLEEPINESS (EDS) ARE INDEPENDENTLY ASSOCIATED WITH DEPRESSION IN A COMMUNITY BASED POPULATION OF AUSTRALIAN MEN. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015. Queensland, AUSTRALIA. 2011 Mee, C. A., Lang, C., Zalewski, P., Mohanasundaram, D. M., Milner, C. R., Drogemuller, C. J. & Coates, P. T. H. (2011). ZINC TRANSPORTER ZIP1 SPECIFIC GENE EXPRESSION KNOCK DOWN ALTERS THE EXPRESSION PROFILE OF OTHER CRITICAL ZINC TRANSPORTERS OF THE MOUSE PANCREAS. 29th Annual Scientific Meeting of the Transplantation-Society-of-Australia-and-New-Zealand. ANU Campus, Canberra, AUSTRALIA. 2010 Hamon, R., Roscioli, E., Lang, C., Murgia, C., Ruffin, R. & Zalewski, P. (2010). Zinc Chelation Induced Depletion Of X-Linked Inhibitor Of Apoptosis Protein (XIAP) In Airway Epithelial Cells. 2010 Zalewski, P., Murgia, C., Roscioli, E., Lang, C., Tran, H., Stoltenberg, M. ... Ruffin, R. (2010). APICAL LOCALIZATION OF ZINC TRANSPORTER ZNT4 IN HUMAN AIRWAY EPITHELIAL CELLS AND ITS LOSS IN A MURINE MODEL OF ALLERGIC AIRWAY INFLAMMATION. 2009 Drogemuller, C. J., Mohanasundaram, D. M., Murgia, C., Mee, C., Milner, C. R., Lang, C. J. ... Coates, P. T. (2009). Transcriptome analysis of isolated human pancreatic islets: expression profiles of zinc transporter genes in particular ZnT8 and ZIP14, critical islet marker genes and glucose metabolic genes. Joint Meeting of the International-Pancreas-and-Islet-Transplant-Association/International-Xenotransplantation-Association. Venice, ITALY. 2006 Murgia, C., Lang, C., Perozzi, G., Ruffin, R. & Zalewski, P. (2006). Zinc fluxes and zinc transporters in the lung and in a mouse model of asthma.. Zn signals (Monte Oliveto Maggiore, Siena, Italy). Siena, Italy. 2006 Orgeig, S., Daniels, C., Lang, C., Postle, A., Panda, A. & Possmayer, F. (2006). The surfactant film under thermal stress: Insights to a new paradigm for surfactant composition & function. International Congress of Respiratory Biology in Bonn, (Bonn, Germany). Bonn, Germany. 2006 Murgia, C., Devirgiliis, C., Zalewski, P., Lang, C. & Perozzi, G. (2006). Zinc fluxes and zinc transporter genes in chronic disease. The International Conference on Nutrigenomics & Gut Health (Auckland, New Zealand). Auckland, New Zealand. 2003 Possmayer, F., Panda, A., Ormond, C., Nag, K., Postle, A., Petersen, N. ... Daniels, C. (2003). Atypical composition and surface molecular organization of pulmonary surfactant from active and torpid fat-tailed dunnarts. 47th Annual Meeting of the Biophysical-Society. SAN ANTONIO, TEXAS. 2001 Lang, C., Orgeig, S. & Daniels, C. (2001). The effect of temperature on alveolar type II cell adrenergic receptors in the fat-tailed dunnart Sminthopsis crassicaudata and the bearded dragon, Pogona vitticeps. Chobe 2001, Second International onference of Comparative Physiology and Biochemistry in Africa, (2001 : Botswana. Africa). Botswana. Africa.
Year Citation 2017 Adams, R., Vincent, A., Appleton, S., Vakulin, A., D'Rozario, A., Catcheside, P. ... Wittert, G. (2017). ASSOCIATION OF DEPRESSION WITH QUANTITATIVE ELECTROENCEPHALOGRAM MEASURES IN ADULT MEN DURING SLEEP. 29th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and Australasian-Sleep-Technologists-Association. Auckland, NEW ZEALAND.
2017 Adams, R., Appleton, S., Vakulin, A., D'Rozario, A., Catcheside, P., Mcevoy, D. ... Wittert, G. (2017). QUANTITATIVE ELECTROENCEPHALOGRAM MEASURES IN ADULT MEN DURING SLEEP: RELATIONSHIP WITH THE APNEA HYPOPNEA INDEX. 29th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and Australasian-Sleep-Technologists-Association. Auckland, NEW ZEALAND.
2016 Adams, R., Appleton, S., Lang, C., Martin, S., Taylor, A., Vakulin, A. ... Wittert, G. (2016). THE EFFECT OF AGE ON COMORBIDITY BURDEN AND INFLAMMATION IN OBSTRUCTIVE SLEEP APNEA. 2016 Lang, C. J., Appleton, S., Vakulin, A., McEvoy, D., Wittert, G., Martin, S. ... Adams, R. (2016). Psychological and quality of life factors in men with comorbid Obstructive Sleep Apnea (OSA) and insomnia (Ins): a population study. Sleep DownUnder 2016: 28th ASM of Australasian Sleep Association and Australasian Sleep Technologists Association. Adelaide, Australia.
- Wormald, PJ*, Koblar, S, Lang C, Lester S, Rischmueller M, Tan LW and Zalewski P. The Hospital Research Foundation Program Grant. $180,000 pa. (2009-2011). Project Title: Inflammatory mechanisms and therapies in chronic disease - asthma, COPD, stroke, cerebrovascular disease, rheumatology diseases and chronic rhinosinusitis. *Alphabetical order after PJ Wormald.
- Lang CJ. Clive and Vera Ramaciotti Foundation Establishment Grant. $27,100. (2007-2009). Project Title: Investigating the role of ZIP1 and ZIP14 in airway inflammation and infection.
- Lang CJ. The Queen Elizabeth Hospital Research Foundation Research Grant. $30,100. (2007-2009). Project Title: Investigating the role of ZIP1 and ZIP14 in airway inflammation and infection.
- Lang CJ, Gualano, R. University of Adelaide, Faculty of Health Science Early Career Research Grant $15,000. (2006-2007). Project Title: The role of zinc in cigarette smoke induced airway inflammation and chronic obstructive pulmonary disease.
Community Grants (voluntary, unrelated to my scientific research)
- On behalf of Dernancourt Uniting Church. The Uniting Foundation $10,000. (2011-2014). Project Title: DUCKS Playgroup Expansion: to establish a playgroup specifically for grandparents, grandparent carers and their grandchildren.
- On behalf of Dernancourt Uniting Church. The Uniting Foundation $50,000 (2016-2018). Project Title: Community Connection and Care for Families.
I have been a research only academic since 2004. However, I have trained and/or supervised numerous research assistants and students (primarily in hands-on laboratory based research techniques) both in Australia and as a visiting researcher overseas. Only some of those I have supervised or co-supervised are listed below:
- 2008-2010 Research Assistant: Rhys Hamon.
- 2007-2010 Part-time Research Assistant: Eugene Roscioli.
- 2007 Casual Research Assistant: Nicola Leung.
- 2005-2006 Part-time Research Assistant: Mary Leong.
- 2006 Part-time Research Assistant: Sook-Ching Lee.
I have had the following training/experience in mentoring and undergraduate teaching at the University of Adelaide:
- Supervising Mentor for a group of 4 Medical Students: MBBS III Research Project. (2016).
- Completed Course in University Teaching for Effective Student Learning (part of the Graduate Certificate in Higher Education). Centre for Learning and Development, University of Adelaide. (2006).
- Workshop on Supervising Postgraduate Research Students, University of Adelaide Graduate Centre. (2005).
Previously I have:
- participated as a mentee in a Mentoring Scheme for Early Career Women Researchers, Flinders University of South Australia.
- worked as a Practical Demonstrator for Biology I, Biology of Organisms I and Zoology II.
- assisted with National Science Week activities.
- been a mentor to secondary students interested in science as a career.
- conducted presentations and informal Chats to students in the University of Adelaide Science Scholars Program.
- helped primary school students complete SASTA Oliphant Science Award projects.
Date Role Committee Institution Country 2012 - 2015 Member School of Medicine Research Committee University of Adelaide Australia 2009 - 2010 Member Institute Management Committee 2009 - 2010 Director Basil Hetzel Early Career Researcher Group 2006 - 2014 Member Discipline of Medicine Research Committee 2006 - 2010 Member University of Adelaide Faculty of Health Sciences Research Career Development Committee 2006 - 2008 Member Basil Hetzel Research Institute Management Committee 2004 - 2007 Chair Basil Hetzel Seminar Series
Date Role Membership Country 2015 - 2016 American Thoracic Society 2014 - 2015 Member Thoracic Society of Australia and New Zealand 2005 - 2010 Thoracic Society of Australia and New Zealand 2005 - 2007 European Respiratory Society 2005 - 2007 Asia Pacific Respiratory Society
Date Institution Department Organisation Type Country 2004 - 2016 Basil Hetzel Institute for Translational Health Research Scientific research
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