Carly Whyte

Dr Carly Whyte

Research Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Carly Whyte is a Cancer Council SA Early Career Research Fellow with expertise in the cellular and molecular mechanisms underlying immune-mediated pathology. Her research focuses on understanding how our immune systems can recognise and respond to cancer, with a view towards developing new immunotherapies for patients with solid tumours, particularly in head and neck cancer.
 
Dr Whyte holds a PhD in Immunology from the University of Adelaide, during which she discovered a previously unknown regulator of immune cell migration into tumours called ACKR4. She was then appointed as a postdoctoral research scientist at the Babraham Institute, Cambridge, UK and a Research Associate at Fitzwilliam College, University of Cambridge. During this postdoctoral training with Prof. Adrian Liston, Dr Whyte elucidated signaling networks of the cytokine IL-2, discovering novel mechanisms of action for this protein and identifying new regulatory networks which explained some of the common side-effects of therapeutic use of IL-2.

Year Citation
2025 Wang, H., Tumes, D. J., Keam, S., Lim, J. W., Nguyen, Q. A., Vlahos, R., . . . Yip, K. H. (2025). βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism. Frontiers in Immunology, 16, 16 pages.
DOI Scopus1 WoS1
2024 Burton, O. T., Bricard, O., Tareen, S., Gergelits, V., Andrews, S., Biggins, L., . . . Liston, A. (2024). The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. Immunity, 57(7), 1586-1602.e10.
DOI Scopus74 WoS65 Europe PMC77
2023 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2023). Correction to: Do more with Less: Improving High Parameter Cytometry Through Overnight Staining (Current Protocols, (2022), 2, 11, 10.1002/cpz1.589). Current Protocols, 3(1), e678.
DOI Scopus2 WoS2 Europe PMC1
2023 Roca, C. P., Burton, O., Neumann, J., Tareen, S., Whyte, C. E., Gergelits, V., . . . Liston, A. (2023). A cross entropy test allows quantitative statistical comparison of t-SNE and UMAP representations. Cell Reports Methods, 3(1, article no. 100390), 1-15.
DOI Scopus24 WoS25 Europe PMC28
2022 Whyte, C. E., Tumes, D. J., Liston, A., & Burton, O. T. (2022). Do more with less: improving high parameter cytometry through overnight staining. Current Protocols, 2(11, article no. e589), 1-20.
DOI Scopus44 WoS41 Europe PMC46
2022 Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L., Whyte, C. E., & Liston, A. (2022). Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology, 23(6), 878-891.
DOI Scopus169 WoS168 Europe PMC174
2022 Whyte, C. E., Singh, K., Burton, O. T., Aloulou, M., & Liston, A. (2022). Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits. Journal of Experimental Medicine, 219(7, article no. e20212391), 1-30.
DOI Scopus39 WoS38 Europe PMC37
2022 Whyte, C. E., Singh, K., Burton, O. T., Aloulou, M., Kouser, L., Veiga, R. V., . . . Liston, A. (2022). Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits (Journal of Experimental Medicine (10.1084/jem.20212391)). Journal of Experimental Medicine, 219(8), e2021239107142022c.
DOI Scopus1
2021 Hill, D. L., Whyte, C. E., Innocentin, S., Le Lee, J., Dooley, J., Wang, J., . . . Linterman, M. A. (2021). Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. eLife, 10(e70554), e70554-1-e70554-30.
DOI Scopus41 Europe PMC46
2021 Roca, C. P., Burton, O. T., Gergelits, V., Prezzemolo, T., Whyte, C. E., Halpert, R., . . . Liston, A. (2021). AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data. Nature Communications, 12(1, article no. 2890), 1-16.
DOI Scopus39 WoS38 Europe PMC41
2021 Hill, D. L., Whyte, C. E., Innocentin, S., Lee, J. L., Dooley, J., Wang, J., . . . Linterman, M. A. (2021). Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. ELIFE, 10, 30 pages.
DOI WoS41
2020 Whyte, C. E., Osman, M., Kara, E. E., Abbott, C., Foeng, J., McKenzie, D. R., . . . McColl, S. R. (2020). ACKR4 restrains antitumor immunity by regulating CCL21. Journal of Experimental Medicine, 217(6), 1-S4.
DOI Scopus31 WoS30 Europe PMC31
2020 Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Whyte, C. E., & Liston, A. (2020). Microglia require CD4 T cells to complete the fetal-to-adult transition. Cell, 182(3), 625-640.
DOI Scopus292 WoS284 Europe PMC308
2020 Nasrallah, R., Imianowski, C. J., Bossini Castillo, L., Grant, F. M., Whyte, C. E., & Roychoudhuri, R. (2020). A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by T.reg cells. Nature, 583(7816), 447-452.
DOI Scopus43 WoS42 Europe PMC52
2020 Liston, A., & Whyte, C. E. (2020). Bile acids mediate signaling between microbiome and the immune system. Immunology and Cell Biology, 98(5), 349-350.
DOI Scopus11 WoS10 Europe PMC9
2019 Koay, H. -F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., . . . Godfrey, D. I. (2019). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. ScienceImmunology, 4(41), eaay6039-1-eaay6039-16.
DOI Scopus98 WoS94 Europe PMC102
2018 Kara, E. E., Bastow, C. R., McKenzie, D. R., Whyte, C. E., Fenix, K. A., Babb, R., . . . McColl, S. R. (2018). Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), 801-813.
DOI Scopus22 WoS22 Europe PMC26
2017 Boyle, S., Gieniec, K., Gregor, C., Faulkner, J., McColl, S., & Kochetkova, M. (2017). Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells. Molecular Cancer, 16(1), 19-1-19-8.
DOI Scopus27 WoS28 Europe PMC25
2017 McKenzie, D., Kara, E., Bastow, C., Tyllis, T., Fenix, K., Gregor, C., . . . McColl, S. (2017). IL-17-producing γδ T cells switch migratory patterns between resting and activated states. Nature Communications, 8(15632), 15632-1-15632-13.
DOI Scopus107 WoS104 Europe PMC105
2015 Kara, E., McKenzie, D., Bastow, C., Gregor, C., Fenix, K., Ogunniyi, A., . . . McColl, S. (2015). CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6(8644), 8644-1-8644-1 7.
DOI Scopus121 WoS116 Europe PMC105
2014 Kara, E., Comerford, I., Fenix, K., Bastow, C., Gregor, C., McKenzie, D., & McColl, S. (2014). Tailored immune responses: novel effector helper T cell subsets in protective immunity. PLoS Pathogens, 10(2), 1003905-1-1003905-15.
DOI Scopus77 WoS67 Europe PMC63
2014 Harata-Lee, Y., Turvey, M., Brazzatti, J., Gregor, C., Brown, M., Smyth, M., . . . McColl, S. (2014). The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT. Immunology and Cell Biology, 92(10), 815-824.
DOI Scopus17 WoS18 Europe PMC18
2013 Comerford, I., Harata-Lee, Y., Bunting, M., Gregor, C., Kara, E., & McColl, S. (2013). A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. Cytokine & Growth Factor Reviews, 24(3), 269-283.
DOI Scopus254 WoS248 Europe PMC237
2010 Comerford, I., Bunting, M., Fenix, K., Haylock-Jacobs, S., Litchfield, W., Harata-Lee, Y., . . . McColl, S. (2010). An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease. Bioessays, 32(12), 1067-1076.
DOI Scopus105 WoS105 Europe PMC93

Year Citation
2017 Gregor, C. E., Kara, E. E., Fenix, K. A., McKenzie, D. R., Comerford, I., & McColl, S. R. (2017). Effector T helper cell recruitment to inflammatory sites via CCR2. In SWISS MEDICAL WEEKLY Vol. 147 (pp. 64S). E M H SWISS MEDICAL PUBLISHERS LTD.

Year Citation
2020 Koay, H. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Whyte, C. E., . . . Godfrey, D. (2020). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. Poster session presented at the meeting of JOURNAL OF IMMUNOLOGY. Honolulu, HI: AMER ASSOC IMMUNOLOGISTS.
2016 Foeng, J., Harata-Lee, Y., Gregor, C., Pederson, S., Brown, M., Symth, M., . . . McColl, S. (2016). The role of ACKR4 in melanoma biology and anti-tumour immunity. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.

Year Citation
2020 Whyte, C., Singh, K., Burton, O., Aloulou, M., Moudra, A., Roca, C., . . . Liston, A. (2020). Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.
DOI Europe PMC2
2020 Roca, C., Burton, O., Prezzemolo, T., Whyte, C., Halpert, R., Kreft, Ł., . . . Liston, A. (2020). AutoSpill: A method for calculating spillover coefficients to compensate or unmix high-parameter flow cytometry data.
DOI Europe PMC2

  • Overcoming immune exhaustion in recurrent head and neck cancer, Garnett Passe & Rodney Williams Memorial Foundation-Conjoint Grant, 01/01/2025 - 31/12/2027

  • Defining the therapeutic potential of eosinophils in melanoma, Australian Melanoma Research Foundation, 01/02/2025 - 31/07/2026

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Co-Supervisor Overcoming immune cell exhaustion in head and neck cancer Doctor of Philosophy Doctorate Full Time Kashaf Tariq

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