Adelaide Medical School
Faculty of Health and Medical Sciences
My research aim is to further develop our understanding of how the brain forms and functions. My research is facilitated by investigating the control of neuro-development by a range of molecular processes (transcriptional, epigenetic and post-translational) in several systems, including patient derived iPS cells.
A further interest is the molecular basis of learning and memory, particularly in post-mitotic neurons.
My broad primary research aim is to unravel the fascinating role of transcriptional regulation, post-transcriptional regulation and epigenetics in neuro-development and cognition (employing, for example, both CRISPR and iPS cells).
Over an extensive research career I have also investigated and retain interest in:
Homeobox gene and other transcription factor function in mouse and human development.
The transcriptional control of early cell fate decisions in the mouse and human.
Maintenance of the stem cell state.
Dissection of promoter regulation of several distinct promoters (for example Oct4 and BCR (BCR-ABL)), and development of drug based strategies to manipulate promoter function.
The detailed study of the IL3/GM-CSF locus using a transgenic mouse model to investigate enhancer and promoter function in distinct immunological states.
Date Position Institution name 2015 Research Officer University of Adelaide 2014 - 2014 Demonstrator and Assessor University of Adelaide 2010 - 2012 Affiliate Lecturer University of Adelaide, Adelaide 2008 - 2012 Senior Research Officer IMVS 2005 - 2007 Research Associate University of Adelaide, Adelaide 2001 - 2004 Research Associate St James University Hospital 1999 - 2000 Research Associate IMVS
Date Institution name Country Title — Flinders University Australia PhD — University of Adelaide Australia Graduate Diploma in Education — University of Adelaide Australia Bsc. Hons
Research InterestsAnimal Cell and Molecular Biology Animal Neurobiology Biochemistry & Molecular Biology Cancer Cell Biology Cell Biology Cell Neurochemistry Cognitive Science Developmental Genetics Epigenetics Gene and Molecular Therapy Gene Expression Genetics & Heredity Neurogenetics Neurosciences Reproductive Biology
2010 Cancer Council SA Project Grant
2011 Research Project Grant, Haematologist's committee RAH
I have a graduate diploma in science education and have taught science at all levels of education. I have supervised Honours and laboratory placement students both in Australia and the United Kingdom.
I have graded and assessed Honours thesis in both Biochemistry and Genetics. I have also assigned essay topics and assessed third year biochemistry students.
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