Dr Blagojce Jovcevski

Postdoctoral Fellow

School of Agriculture, Food and Wine

Faculty of Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Blagojce completed his PhD at the University of Wollongong in 2017, under the supervision of Prof. Heath Ecroyd focusing on understanding the structure-function relationship of small heat-shock proteins, which are associated with numerous neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, using native mass spectrometry and biophysical approaches.

Currently, Blagojce is a Postdoctoral Research Fellow working with Assoc. Prof. Tara Pukala (School of Physical Sciences) to utilise mass spectrometry-based techniques to understand the aggregation dynamics of α-synuclein in various lipid environments. In addition, Blagojce is also working on characterising the structure and dynamics of transmembrane chitin synthases using native ion mobility - mass spectrometry with Prof. Vincent Bulone (School of Agriculture, Food and Wine).

My Research
Career
Publications
Supervision
Professional Activities
Contact

Investigating the structure of amyloidogenic proteins using mass spectrometry-based approaches

The pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease and amyotrophic lateral sclerosis, is believed to be caused by the aggregation of non-native proteins. One such protein that forms fibril (amyloid) aggregates is alpha-synuclein, which is heavily associated with Parkinson's disease. My current focus is on understanding the role lipids play in the aggregation dynamics of alpha-synuclein using a range of mass spectrometry-based approaches. Native MS is a high-resolution tool utilised in structural biology which can define a range of structural features within proteins, such as oligomeric distribution and polydispersity, unfolded/unstructured states, assembly stability and quaternary conformation of proteins. Using these techniques, in conjunction with other biophysical tools, can provide a structural rationale for protein function/dysfunction.

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Appointments

Date	Position	Institution name
2020	Postdoctoral Research Fellow, Department of Agricultural Science	University of Adelaide
2017	Postdoctoral Research Fellow, Department of Chemistry	University of Adelaide

Education

Date Institution name Country Title
2012 - 2017 University of Wollongong Australia PhD
2007 - 2011 University of Wollongong Australia Bachelor of Science (Honours) (Biological Sciences)
Research Interests

Biochemistry & Molecular Biology Biophysics Cell Biology Cellular Interactions Characterisation of Biological Macromolecules Medical Biochemistry: Proteins and Peptides Microbiology Molecular Targets Neurosciences Protein Trafficking Proteins and Peptides Proteomics and Intermolecular Interactions Structural Biology

Date	Institution name	Country	Title
2012 - 2017	University of Wollongong	Australia	PhD
2007 - 2011	University of Wollongong	Australia	Bachelor of Science (Honours) (Biological Sciences)

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Journals

Year	Citation
2020	Sajid, M. S., Jovcevski, B., Pukala, T. L., Jabeen, F., & Najam-Ul-Haq, M. (2020). Fabrication of Piperazine Functionalized Polymeric Monolithic Tip for Rapid Enrichment of Glycopeptides/Glycans.. Anal Chem, 92(1), 683-689. DOI
2020	Sanders, H. M., Jovcevski, B., Carver, J., & Pukala, T. L. (2020). The molecular chaperone β-casein prevents amorphous and fibrillar aggregation of α-lactalbumin by stabilisation of dynamic disorder. Biochemical Journal, 477(3), 629-643. DOI
2020	Wang, C. R., Bubner, E. R., Jovcevski, B., Mittal, P., & Pukala, T. L. (2020). Interrogating the higher order structures of snake venom proteins using an integrated mass spectrometric approach.. J Proteomics, 216, 103680. DOI
2020	Horsley, J. R., Jovcevski, B., Wegener, K. L., Yu, J., Pukala, T. L., & Abell, A. (2020). Rationally Designed Peptide-Based Inhibitor of Aβ42 Fibril Formation and Toxicity: A Potential Therapeutic Strategy for Alzheimer's Disease.. Biochem J, 477(11), 2039-2054. DOI
2020	Yeoh, Y., Horsley, J., Yu, J., Polyak, S., Jovcevski, B., & Abell, A. (2020). Short Photoswitchable Antibacterial Peptides. ChemMedChem. DOI
2019	Liu, Y., Jovcevski, B., & Pukala, T. (2019). C-Phycocyanin from Spirulina Inhibits α-synuclein and amyloid-β fibril formation but not amorphous aggregation. Journal of Natural Products, 82(1), 66-73. DOI Scopus2 WoS3
2018	Jovcevski, B., Andrew Aquilina, J., Benesch, J., & Ecroyd, H. (2018). The influence of the N-terminal region proximal to the core domain on the assembly and chaperone activity of αB-crystallin. Cell Stress and Chaperones, 23(5), 827-836. DOI Scopus3 WoS3 Europe PMC1
2017	Jovcevski, B., Kelly, M., Aquilina, J., Benesch, J., & Ecroyd, H. (2017). Evaluating the effect of phosphorylation on the structure and dynamics of Hsp27 dimers by means of ion mobility mass spectrometry. Analytical Chemistry, 89(24), 13275-13282. DOI Scopus4 WoS4
2015	Jovcevski, B., Kelly, M., Rote, A., Berg, T., Gastall, H., Benesch, J., . . . Ecroyd, H. (2015). Phosphomimics destabilize Hsp27 oligomeric assemblies and enhance chaperone activity. Chemistry and Biology, 22(2), 186-195. DOI Scopus55 WoS52 Europe PMC31
2015	Cork, A., Ericsson, D., Law, R., Casey, L., Valkov, E., Bertozzi, C., . . . Kobe, B. (2015). Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase. PLoS ONE, 10(3), e0121764-1-e0121764-18. DOI Scopus6 WoS7 Europe PMC4
2013	Henningham, A., Ericsson, D., Langer, K., Casey, L., Jovcevski, B., Singh Chhatwal, G., . . . Walker, M. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4(4), e00509-13-1-e00509-13-9. DOI Scopus15 WoS14 Europe PMC7

Book Chapters

Year	Citation
2019	Jovcevski, B., & Pukala, T. (2019). Mass Spectrometry and Its Applications. In V. Ramesh (Ed.), Biomolecular and Bioanalytical Techniques Theory, Methodology and Applications (pp. 219-253). USA: Wiley.

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Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2020	Co-Supervisor	Mass Spectrometric Characterisation of Protein Assemblies from Snake Venom	Master of Philosophy	Master	Full Time	Miss Emily Rose Bubner

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Committee Memberships

Date Role Committee Institution Country
2019 - ongoing Member Lorne Proteins ECR Committee Lorne Proteins Australia

Date	Role	Committee	Institution	Country
2019 - ongoing	Member	Lorne Proteins ECR Committee	Lorne Proteins	Australia

Memberships

Date	Role	Membership	Country
2019 - ongoing	Member	Australian and New Zealand Society for Mass Spectrometry	Australia
2018 - ongoing	Member	Adelaide Protein Group	Australia
2018 - ongoing	Member	Australian Society for Biochemistry and Molecular Biology	Australia
2017 - ongoing	Member	Cell Stress Society International	United States

Position: Postdoctoral Fellow
Phone: 83134903
Email: blagojce.jovcevski@adelaide.edu.au
Fax: 8313 4380
Campus: North Terrace
Building: Molecular Life Sciences Building, floor 1
Room: 1 50
Org Unit: Chemistry

Dr Blagojce Jovcevski

Appointments

Education

Research Interests

Journals

Book Chapters

Current Higher Degree by Research Supervision (University of Adelaide)

Committee Memberships

Memberships

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External Profiles