Blagojce Jovcevski

Dr Blagojce Jovcevski

Grant-Funded Researcher (A)

School of Agriculture, Food and Wine

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Blagojce completed his PhD at the University of Wollongong in 2017, under the supervision of Prof. Heath Ecroyd focusing on understanding the structure-function relationship of small heat-shock proteins, which are associated with numerous neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, using native mass spectrometry and biophysical approaches.

Blagojce joined the University of Adelaide in late 2017 in the Department of Chemistry (School of Physical Sciences) and also joined the Department of Food Science (School of Agriculture, Food and Wine) in 2020.

Blagojce is a Postdoctoral Research Fellow working with Assoc. Prof. Tara Pukala (School of Physical Sciences, Adelaide Proteomics Centre) to utilise mass spectrometry-based techniques to understand the aggregation dynamics of amyloid-fibril forming proteins and their affects on proteostasis. In addition, Blagojce is also an Associate Investigator for the Research Consortium Program for Agriculture Product Development which is supported by the South Australia Department for Industry and Skills to discover and repurpose bioactive molecules from agricultural and food waste for industry and biomedical applications. 

Investigating the structural dynamics of amyloidogenic proteins using mass spectrometry-based approaches

The pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson's disease and amyotrophic lateral sclerosis, is believed to be caused by the aggregation of non-native proteins. My focus is on understanding the role lipids play in the aggregation dynamics of alpha-synuclein using a range of mass spectrometry-based approaches. Native MS is a high-resolution tool utilised in structural biology which can define a range of structural features within proteins, such as oligomeric distribution and polydispersity, unfolded/unstructured states, assembly stability and quaternary conformation of proteins. Using these techniques, in conjunction with other biophysical tools, can provide a structural rationale for protein function/dysfunction. 

Development of novel peptide-based protein aggregation inhibitors and enzymatic-targetting antimicrobials

My work has also facilitated structure-informed design of peptide-based inhibitors of amyloid fibril formation as potential therapeutics of diseases where protein misfolding and aggregation are central, as well as enzymatic inhibitor screening of novel antimicrobial drugs targeting bacterial and fungal pathogens in collaboration with The Institute for Photonics and Advanced Sensing (IPAS)

Utilising MS approaches as a complementary tool in structural biology and structure-activity relationships

We continuely utilise MS-based approaches to complement traditional structural biology approaches (e.g. X-ray crystallography, cryo-EM, NMR) to structurally rationalise biomolecular function/activity to guide antifungal drug design and vaccine design against infectious disease. In addition, these approaches have been crucial in discovering venom proteomes and their role in envenomation and developing novel glycopeptide enrichment stratergies for disease diagnostics.

 

Year Funding Source Amount (AUD)
2019 Postdoctoral Travel Award Lorne Conference on Protein Structure and Function (Sole CI) $250
2018 Australian Bicentennial Fellowship Travel Award, Menzies Australian Institute (Sole CI) $1,800
2015 American Society of Mass Spectrometry Asilomar Conference on Native Mass Spectrometry Travel Award, American Society of Mass Spectrometry (Sole CI) $1,500
2013-14 Faculty of Science, Medicine and Health Travel Award, University of Wollongong (Sole CI) $3,000
2012-16 Henning Family Foundation PhD Scholarship, Australian Rotary Health (Sole CI) $101,500
  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2021 Co-Supervisor Investigating the formation, inhibition and detection of amyloid oligomers in the context of neurodegenerative disease Master of Philosophy Master Full Time Mr Shaun Thomas Ellis
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2020 - 2021 Co-Supervisor Mass Spectrometric Characterisation of Protein Assemblies from Bitis arietans Snake Venom Master of Philosophy Master Full Time Miss Emily Rose Bubner
    2020 - 2021 Co-Supervisor Structural and Biochemical Insights into Antifungal Drug Targets from Aspergillus fumigatus Doctor of Philosophy Doctorate Full Time Ms Stephanie Nguyen
  • Position: Grant-Funded Researcher (A)
  • Phone: 83134903
  • Email: blagojce.jovcevski@adelaide.edu.au
  • Fax: 83134380
  • Campus: North Terrace
  • Building: Molecular Life Sciences, floor 1
  • Org Unit: Agricultural Science

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